task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]1C[C@H]1C(=O)N[C@@H]1CCCCC[C@@H]1C(=O)[O-] ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1cccc(O)c1 Fragment 2: [16*]c1cccc(O)c1 ### Response: C[C@H]1[C@H](Cc2cccc(O)c2)CC[C@@H]1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN([5*])CC1 Fragment 2: [14*]c1ncccc1F ### Response: O=C(c1cc2ccccc2[nH]1)N1CCN(c2ncccc2F)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C)c1c(CC(NCC)=O)c2c(cc(Br)cc2)cc1 ### Response: CCNC(=O)Cc1c(OC)ccc2cc(Br)ccc12
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH+](Cc1ccccc1NC(=O)N1CCN(Cc2ccncc2)CC1)C1CCCCC1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NC(NCCC)=O)CN1C(=O)[C@](NC1=O)(c1ccccc1)Cc1ccccc1 ### Response: CCCNC(=O)NC(=O)CN1C(=O)N[C@](Cc2ccccc2)(c2ccccc2)C1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(C(N[C@H](c2scc(C)n2)C2CC2)=O)[C@@H](COCC1)C1CC1 ### Response: Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCc1nc(C)cc(NCc2cccc(OCC#N)c2)n1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc([C@H]2C[C@H]2C[NH3+])c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? COC(=O)[C@H](C)C[S@](=O)Cc1nc(C)c(C)s1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1ccccc1)n1c(n[nH]c1=O)C1CC[NH+](CC1)Cc1cnc(nc1)N ### Response: Nc1ncc(C[NH+]2CCC(c3n[nH]c(=O)n3Cc3ccccc3)CC2)cn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(Cc1ccc(OC)cc1)S(=O)(=O)c1sccc1Br ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1CCC[C@@H]1c1cccs1)C(C)(C)C ### Response: CC(C)(C)C(=O)N1CCC[C@@H]1c1cccs1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2nnc(NC(=O)C3CC3)o2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(CC1CC1)N1CC[C@]2(CCCN(Cc3ccc(F)c(F)c3)C2=O)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=c1[nH]c2ccc(-c3csc(NC[C@H]4CCCO4)n3)cc2[nH]1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cc(C)c(C)cc1S(=O)(=O)NC[C@@](C)(O)CSC ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(/C=N/NC(=O)C(=O)N2CCCCC2)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@H](c1ccccc1)[S@](=O)CC(=O)Nc1cccc(C#N)c1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? O=C1[C@H]([NH+]2CCCC[C@@H]2CN2CCOCC2)CCN1C1CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(N2CCN(CC2)C(c2c([nH]c(-c3ccc(C)cc3)c2)C)=O)cc1)Cl ### Response: Cc1ccc(-c2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)c(C)[nH]2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]([8*])C Fragment 2: [1*]C(=O)C([1*])=O ### Response: COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@H]1CCOC1 Fragment 2: [3*]Oc1cc([C@H]([4*])C)ccn1 ### Response: CC[NH2+][C@H](C)c1ccnc(O[C@H]2CCOC2)c1
functional_group
### Instruction: Does the molecule contain a thiol group? CC(C)C[C@H](CNC(=O)c1ccc(O)cc1O)C(=O)[O-] ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC(C[NH+]2C[C@@H](NC(=O)c3cc([nH]n3)C)CC2)C1 ### Response: Cc1cc(C(=O)N[C@H]2CC[NH+](CC3CCCC3)C2)n[nH]1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+][C@@H](C)CC(C)(C)Cc1nc(C)c(C)s1 ### Response: 5
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(c1cc(c(F)cc1)NC(=O)C(N1C[C@@H](C(CC)CC)CC1)=O)N(C)C ### Response: CCC(CC)[C@H]1CCN(C(=O)C(=O)Nc2cc(C(=O)N(C)C)ccc2F)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1CCC[C@H](C)N1C(=O)CSc1nc2ccccc2n1CC(=O)N1CCCCC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc([16*])c1C Fragment 2: [14*]c1cc2ccccc2o1 ### Response: Cc1c(NC(=O)N[C@H](C)c2cc3ccccc3o2)cccc1C(=O)N1CCOCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(C[C@H]2[C@H](N(CCc3ccccc3)C(=O)CC2)CC1)C(c1n[nH]cc1)=O ### Response: O=C(c1cc[nH]n1)N1CC[C@@H]2[C@@H](CCC(=O)N2CCc2ccccc2)C1
functional_group
### Instruction: Does the molecule contain a ketone group? C[NH+](C)CCO[C@@H]1C[C@@H]2CC[C@@]1(C)C2(C)C ### Response: No
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(Br)c(O)c(/C=N/NC(=O)CSCc2ccccc2)cc1Br ### Response: O=C(CSCc1ccccc1)N/N=C/c1cc(Br)cc(Br)c1O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1ccc2c(c1)O/C(=C\C1=Cc3ccccc3OC1)C2=O ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)C(=O)c1ccc(C[NH+](C)CCCc2n[nH]c(N)c2C#N)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc(Nc2nnc(C(C)(C)C)c(=O)n2N)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ketone group? COc1ccc(-n2ncc3c2C[C@@H](c2ccc(F)cc2)CC3=O)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitro group? COCC[NH+]1CCC[C@@H](NC(=O)N(C2CC2)[C@H](C)C2CC2)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](CC(=O)N(C)C1CCS(=O)(=O)CC1)c1ccccc1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a nitrile group? CCCOc1cc(N2CCN(C(=O)C(C)C)CC2)nc(C)n1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCc2c1oc1ccc(OCC(Nc3ccc(cc3)NC(=O)C(C)C)=O)cc21 ### Response: CC(C)C(=O)Nc1ccc(NC(=O)COc2ccc3oc4c(c3c2)CCCC4)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(n1c2c([nH]c(c1=O)=O)cc(C(NCc1nc(C)c(s1)C)=O)cc2)C ### Response: CCn1c(=O)c(=O)[nH]c2cc(C(=O)NCc3nc(C)c(C)s3)ccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)NC(=O)c1ccc(cc1)I)NC(c1cccs1)=O ### Response: O=C(Nc1ccc(NC(=O)c2cccs2)cc1)c1ccc(I)cc1
functional_group
### Instruction: Does the molecule contain a carboxyl group? CN1CCN(C(=O)Nc2ccc[nH+]c2N2CCCC2)[C@@H](c2ccccc2)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. CCCCN1C([C@H]2Cc3c([nH]c4c3cccc4)[C@H](N2C(C1)=O)c1cc([N+]([O-])=O)ccc1)=O ### Response: CCCCN1CC(=O)N2[C@H](c3cccc([N+](=O)[O-])c3)c3[nH]c4ccccc4c3C[C@@H]2C1=O
functional_group
### Instruction: Does the molecule contain a amide group? COc1n[nH]c(C(=O)Nc2cc(F)ccc2C)c1[N+](=O)[O-] ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [5*]NC1CC[NH+]([5*])CC1 ### Response: CC(=O)NC1CC[NH+](Cc2cnc(C3CC3)s2)CC1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1cc(C(=O)N2CCC[C@H](CCC(=O)NCc3ccc(F)c(F)c3)C2)nc(C)n1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2c(c1)[nH]c1c([O-])nc(NC(=O)c3ccccc3)nc12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]([8*])O Fragment 2: [11*]S[C@@H]1[NH+]=c2ccc(C)cc2=[NH+]1 ### Response: Cc1ccc2c(c1)=[NH+][C@H](SC[C@@H](O)c1ccccc1)[NH+]=2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(N[C@@H]2C(C)(C)CCSC2)c(F)cc1)C(OC)=O ### Response: COC(=O)c1ccc(F)c(N[C@H]2CSCCC2(C)C)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[NH+](C)CCC(NC(=O)[C@H](N(S(=O)(=O)C)c2cc(cc(C)c2)C)CC)C1 ### Response: CC[C@H](C(=O)NC1CC[NH+](C)CC1)N(c1cc(C)cc(C)c1)S(C)(=O)=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1sc2ncn([9*])c(=O)c2c1C Fragment 2: [5*]Nc1ccccc1 ### Response: Cc1c(C(=O)Nc2ccccc2)sc2ncn(CC(=O)Nc3cccc4ccccc34)c(=O)c12
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CN(C[C@@H]1COc2ccccc2O1)C(=O)c1cccc(S(=O)(=O)NCc2cccs2)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H]([NH3+])Cc1ccc(OCC2CC2)cn1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCSC1(CNC(=O)Nc2cc(-c3ccccc3)on2)CCOCC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)C[C@H]2C(=O)NCCN2C(=O)C[NH+]2CCN(c3ccccc3F)CC2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amine group? Cc1ccc(C(=O)C2=C([O-])C(=O)N(CCc3ccccc3)[C@@H]2c2ccccc2)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)C(C)(C)C[NH2+][C@@H]1CCCCC[C@H]1C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(N)cc1 Fragment 2: [16*]c1ccc(N)cc1 ### Response: N#CCN(CC#N)C[C@@H](O)COc1ccc(N)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)c1nc(C[NH+]2CCC[C@@H](C(=O)N3CCOCC3)C2)cs1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1CC=CCC1 Fragment 2: [5*]NC[C@H]1N=NC2=C1CCCCC2 ### Response: O=C(NC[C@H]1N=NC2=C1CCCCC2)[C@H]1CC=CCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(=O)c1cc(c(OC)cc1)CC(N[C@@H]1[C@H]2[C@@H](C1(C)C)OCC2)=O ### Response: COc1ccc(C(C)=O)cc1CC(=O)N[C@@H]1[C@@H]2CCO[C@@H]2C1(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)NNC(=O)[C@H](C)C[8*] Fragment 2: [15*]C1CCCC1 ### Response: C[C@H](CC1CCCC1)C(=O)NNC(=O)[C@H]1COc2ccccc2O1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC([15*])CC1 Fragment 2: [16*]c1ccc(C)nc1 ### Response: Cc1ccc(OC2CCN(C(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)CC2)cn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [1*]C(=O)CC[8*] ### Response: Cc1sc2ncn(CCC(=O)N(C)[C@H](C)c3ccco3)c(=O)c2c1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cnnc1S[11*] Fragment 2: [5*]Nc1cc(F)ccc1C ### Response: COCCn1cnnc1S[C@@H](C)C(=O)Nc1cc(F)ccc1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc([C@H](C)NC(=O)/C(C#N)=C/[C@H]2C=NN=C2c2ccccc2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSc1cccc(NC(=O)CSCc2cccc(Cl)c2)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc2c(c1)N(CC=C)C(=O)C(C)(C)CO2 Fragment 2: [1*]C(=O)CCCCl ### Response: C=CCN1C(=O)C(C)(C)COc2ccc(NC(=O)CCCCl)cc21
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(S(=O)(=O)N2CCCN(C(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)CC2)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [4*][C@H]([8*])c1cccs1 ### Response: CC[C@@H](C)[C@@H](O)C[NH2+][C@@H](c1cccs1)C1CC1
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc(CCC(=O)N2CCCN(C(=O)C3=Cc4cc(Cl)ccc4OC3)CC2)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc(-c2noc(CN(C(=O)c3ccc(C)c([N+](=O)[O-])c3)C3CCCCC3)n2)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C1OCCCC=1)NCCC(=O)Nc1c(C)ccc(Br)c1 ### Response: Cc1ccc(Br)cc1NC(=O)CCNC(=O)C1=CCCCO1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)[C@@H]([NH2+][C@@H]1CSCC(C)(C)C1)C(=O)[O-] ### Response: 4
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(CC(=O)N(C)C)C(=O)[C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(N=[P@@](c2ccncc2)(N2CCCC2)C(C)(C)C)c(C)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1CC=CC[C@@H]1COC(=O)C1CCN(C(=O)c2ccc(F)cc2)CC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC(=O)Oc1cccc([N+](=O)[O-])c1C ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1cc[nH+]c1CN[C@@H]1CCC[C@@H]1[C@@H]1CCC[NH2+]1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a nitrile group? CC(=O)N1CCc2cc(C(=O)N[C@@H](CC(C)C)c3nc4ccccc4[nH]3)ccc21 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2cc(-c3ccccc3)cc(-c3ccc(I)cc3)[o+]2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? COC(=O)N1CCC[C@@H]1C(=O)N[C@H](C)c1cn(C)nc1C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)Nc1cc(C)ccc1C)Sc1cc(-c2ccccn2)nc(C)n1 ### Response: Cc1ccc(C)c(NC(=O)CSc2cc(-c3ccccn3)nc(C)n2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. s1c(c(N)c2c1nccc2)C(=O)N1CCC(C)CC1 ### Response: CC1CCN(C(=O)c2sc3ncccc3c2N)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1c([C@H]2CCCN(S(C)(=O)=O)C2)nn(CC(=O)Nc2ccccc2)c1=O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1c2ccc(OC)cc2C=C[C@H]1C#N Fragment 2: [1*]C(=O)c1ccccc1 ### Response: COc1ccc2c(c1)C=C[C@@H](C#N)N2C(=O)c1ccccc1
functional_group
### Instruction: Does the molecule contain a ester group? COc1ccc(CNC(=O)COc2c(C)cc(Cl)cc2C=O)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCC(n2c(nnc2SCCOC(C)C)-c2occc2)C1 ### Response: CC(C)OCCSc1nnc(-c2ccco2)n1C1CCCCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Nc1ccc(OC(=O)Nc2ccc(O)cc2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O=C(CN1CCN(C(=O)[C@H]2CCCO2)CC1)Nc1ccc(F)c(Cl)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? C[C@]12CCC(=O)N1c1ccccc1C(=O)N2CCC(=O)NCc1ccc(O)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N#Cc1ccc(NC(=O)C(=O)N2C[C@H]3CC=CC[C@@H]3C2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(=O)[C@H]1CCCCN1C(=O)c1nc2c(cc1)cccc2)C ### Response: CNC(=O)[C@H]1CCCCN1C(=O)c1ccc2ccccc2n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccco1)c1ccc2ccccc2c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1C[NH+](CCn2c(=O)oc3cccnc32)CCN1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](Cc1cccs1)N(C)C(=O)N1CC[C@@H](CC(=O)[O-])C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCNCC(=O)Nc1ccc(S(C)(=O)=O)nc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C(=O)N[C@H](C)Cn2nc(C)cc2C)c2cccc(C)c2n1 ### Response: 3