task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ccc(Br)cc1 Fragment 2: [1*]C(=O)C1CCN([5*])CC1 ### Response: CCCCS(=O)(=O)N1CCC(C(=O)NCc2ccc(Br)cc2)CC1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[NH2+][C@H](Cc1ccc2ccccc2n1)[C@@]1(C)CCCO1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)ccc(cc1Cl)OC(F)(F)F ### Response: Cc1ccc(OC(F)(F)F)cc1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCc1cc(Cl)cc(Cl)c1 Fragment 2: [16*]c1cc(Cl)cc(Cl)c1 ### Response: CCc1onc(C)c1NC(=O)NCCc1cc(Cl)cc(Cl)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [5*]Nc1ccc(F)c(F)c1 ### Response: CCOc1ccc(-c2ccc(=O)n([C@H](C)C(=O)Nc3ccc(F)c(F)c3)n2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1sc(Br)c(C)c1)[NH+]1[C@H](c2c(C)n(C)nc2)CCC1 ### Response: Cc1cc(C[NH+]2CCC[C@H]2c2cnn(C)c2C)sc1Br
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-c2ccc(=O)n([C@@H](C)C(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)n2)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(c2ccccc2o1)NC(C[NH+]1CCOCC1)=O)C(=O)c1ccc(cc1)F ### Response: O=C(C[NH+]1CCOCC1)Nc1c(C(=O)c2ccc(F)cc2)oc2ccccc12
functional_group
### Instruction: Does the molecule contain a amide group? O=C(NC[C@H]1CCCN(c2nnnn2-c2ccccc2)C1)c1cccnc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc([16*])cc1 Fragment 2: [14*]c1nc2ccccc2s1 ### Response: CC(=O)NC(=S)NCc1ccc(-c2nc3ccccc3s2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [nH]1ccc(C[NH+]2CC3(CC2)CCCCC3)n1 ### Response: c1cc(C[NH+]2CCC3(CCCCC3)C2)n[nH]1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(C)c([C@H](O)CNC2(c3nccs3)CCCC2)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(CCNC(=O)c1ccc2c(c1)NC(=O)CS2)c1cccc(C)c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(NC([C@@H]2c3c(NC(C2)=O)nc([nH]c3=O)SCc2ccc(F)cc2)=O)ccccc1C ### Response: Cc1ccccc1NC(=O)[C@H]1CC(=O)Nc2nc(SCc3ccc(F)cc3)[nH]c(=O)c21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C(=O)Nc2cc(C(=O)N(C)C)ccc2C)ccc1F ### Response: 0
functional_group
### Instruction: Does the molecule contain a phenol group? COc1ccc(Br)c(C(=O)N[C@H](C)c2ccncc2)c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCS[11*] Fragment 2: [1*]C(=O)C[C@@H]1CCc2ccccc21 ### Response: Cc1[nH+]c[nH]c1CSCCNC(=O)C[C@@H]1CCc2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cc1c[nH]c2ccccc12)Nc1cc(Cl)cc(Cl)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)[C@@H]([NH2+]Cc1ccc(C[NH+]2CCCC[C@@H]2C)cc1)c1cccnc1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCOc1ccc(NC(=O)N2CCOC[C@H]2C2CC2)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)Sc1ccccc1C(=O)NCc1ccccn1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1cc(c(cc1)-c1nnc(s1)N)O)C ### Response: COc1ccc(-c2nnc(N)s2)c(O)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1ccccc1[C@@H](C)[NH2+]Cc1cc(F)cc(OC)c1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccc(NC(=O)CCNC(=O)c2cnc([C@H]3CCCO3)s2)n1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [1*]C(=O)C(C)(C)C ### Response: CC(C)(C)C(=O)N1CCC[C@@H]1c1cccs1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(OC)cc1 Fragment 2: [3*]Oc1ncnc(N[5*])c1[N+](=O)[O-] ### Response: COc1ccc(Oc2ncnc(Nc3cc(F)ccc3F)c2[N+](=O)[O-])cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH+]12C[C@H]3[C@H]([C@H]2CCCC1)CN(C3)Cc1c(C)nn(CC(C)C)c1OCC ### Response: CCOc1c(CN2C[C@H]3C[NH+]4CCCC[C@@H]4[C@@H]3C2)c(C)nn1CC(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN([5*])CC1 Fragment 2: [1*]C(=O)c1c(C)oc2nc[nH]c(=O)c12 ### Response: CC[C@H](O)CN1CCN(C(=O)c2c(C)oc3nc[nH]c(=O)c23)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCNC(=O)c1cn2c(n1)CCCC2 ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? CCc1ccc(C(=O)c2ccc(OC)cc2)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](NC(=O)C(C)(C)C)C(=O)N1CCN(c2cc[nH+]cc2)CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1oc([C@H]([NH+](C)C)CNS(c2ccc(CC#N)cc2)(=O)=O)cc1 ### Response: C[NH+](C)[C@H](CNS(=O)(=O)c1ccc(CC#N)cc1)c1ccco1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)c1cnn(-c2ccc(OC(F)(F)Cl)cc2)c1N ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](NC(=O)N1CCC(NS(=O)(=O)c2cccs2)CC1)c1ccc(F)cc1F ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? C[NH2+]C[C@@H](C)C(=O)N(C)c1cccc(C#N)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: O=C(CC(C1CC1)C1CC1)N1CCN([C@@H]2CCC[C@H]2O)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(c(C[S@@](CCn3cccn3)=O)nn2-c2ccccc2)CCC1 ### Response: O=[S@](CCn1cccn1)Cc1nn(-c2ccccc2)c2c1CCC2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(=O)N1CCC([NH+]2CCN(c3ncc(Cl)cc3Cl)CC2)CC1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? O=C(NCc1ccco1)C(=O)Nc1nc(-c2ccccc2)cs1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCS1(=O)=O Fragment 2: [5*]Nc1ccc(C)c([16*])c1 ### Response: Cc1cc(C(=O)Nc2ccc(C)c(N3CCCS3(=O)=O)c2)no1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cc(C)cn1 Fragment 2: [8*]Cn1cc(C)cn1 ### Response: Cc1cnn(Cc2cc(C(=O)N3c4ccccc4CC[C@@H]3C(C)C)no2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(=O)N(Cc1ccccc1OCC)C)c1cc(NC(CC)=O)ccc1C ### Response: CCOc1ccccc1CN(C)C(=O)Nc1cc(NC(=O)CC)ccc1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]O[C@H](C)C(F)(F)F Fragment 2: [1*]C(=O)c1cccc(OC)c1F ### Response: COc1cccc(C(=O)O[C@H](C)C(F)(F)F)c1F
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCOC(=O)c1[nH]c(C)c(C(=O)Nc2ccc(Cl)cc2)c1CC ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)C[NH+]1CCCN(C(=O)Nc2ccc(Cl)cc2)CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aldehyde group? CCC[NH+]1CCC[C@@H]([NH2+]CC2CCC(C(=O)[O-])CC2)CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1ncc([C@H]2NC(=O)c3cccnc3N2)s1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@H]([NH3+])c1oc2ccc(F)cc2c1C Fragment 2: [14*]c1oc2ccc(F)cc2c1C ### Response: Cc1c([C@@H]([NH3+])c2ccc(Br)cc2)oc2ccc(F)cc12
canonicalization
### Instruction: Canonicalize the following SMILES string. Fc1ccc(cc1)/C=C1\C(N(NC1=O)c1ccc(C)c(C)c1)=O ### Response: Cc1ccc(N2NC(=O)/C(=C/c3ccc(F)cc3)C2=O)cc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](C)Cc1cccc(C[NH2+]Cc2ccn(-c3ccccc3)n2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(F)(F)F Fragment 2: [5*]N[C@H]1c2ccccc2C[C@H]1O ### Response: C[C@H](Cc1cccc(C(F)(F)F)c1)C(=O)N[C@H]1c2ccccc2C[C@H]1O
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH2+]Cc1ccn(Cc2cccc(O)c2)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C[C@H](O)[C@@H](O)[C@H]1O[C@H](c2ccccc2)OC[C@H]1O ### Response: Yes
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCc2sccc2C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[NH+](CCC(=O)NC(=O)Nc1ccccc1)Cc1ccccc1F ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? Cc1ccc(/C=N/c2ccccc2C#N)s1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? CCNC(=O)c1ccc(NC(=O)C(=O)N2C[C@@H]3[C@H](C2)C3(C)C)cc1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1[C@@H](C)C(=O)CC[NH+]1CCc1ccc(F)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1=NC(=O)[C@@H](CC(=O)Nc2ccc(C(C)C)cc2)C(C)=N1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(c1ccccc1C)S(=O)(=O)c1cc2c3c(c1)CC(=O)N3CCC2 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC(=O)Nc1ccc(C(=O)CSc2ccc(F)cc2)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. FC(F)(F)c1ccccc1CN(Cc1cnc[nH]1)C1CCCC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@H]1CC(C(=O)N[C@@H]2CC(=O)N(C)[C@@H]2c2ccc(Cl)cc2)C[C@H](C)O1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(ccc1)Cl)[C@@H](NC(=O)Nc1ccc(cc1)[N-]S(C)(=O)=O)C ### Response: C[C@H](NC(=O)Nc1ccc([N-]S(C)(=O)=O)cc1)c1cccc(Cl)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12ncn(c(=O)c1cccc2)[C@@H](CC)C(Nc1ccc(cc1)NC(C)=O)=O ### Response: CC[C@@H](C(=O)Nc1ccc(NC(C)=O)cc1)n1cnc2ccccc2c1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cnc([14*])s1 Fragment 2: [5*]N(C)C ### Response: CN(C)c1ncc(C[NH+]2CCC[C@@H]3CCC[C@@H]32)s1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(=O)(N1CCCC[C@H]1C)c1cc(ccc1)C(N(C)Cc1ccc(o1)C)=O ### Response: Cc1ccc(CN(C)C(=O)c2cccc(S(=O)(=O)N3CCCC[C@H]3C)c2)o1
canonicalization
### Instruction: Canonicalize the following SMILES string. C/C=C1/C[NH+]2CC[C@@]34c5c(N[C@H]4[C@H]([C@H]1C[C@@H]32)CO)cccc5 ### Response: C/C=C1/C[NH+]2CC[C@]34c5ccccc5N[C@H]3[C@@H](CO)[C@H]1C[C@H]24
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccccc1C(C)(C)CNC(=O)CCCN1CCOC1=O ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1c2ccccc2C(=O)N1N=Cc1ccc(/C=N/N2C(=O)c3ccccc3C2=O)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc2c(c1)COC2 Fragment 2: [3*]OCC[4*] ### Response: Cc1cc(C)cc(OCCNC(=O)Nc2ccc3c(c2)COC3)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nc(-c2ccccn2)sc1C(=O)N1CCN(c2ccccc2O)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(c2oc(cc2c1)C(=O)Nc1n(C(C)C)ncc1)OC ### Response: COc1cccc2cc(C(=O)Nc3ccnn3C(C)C)oc12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(-c2nnn(CC#Cc3ccc(Cl)cc3)n2)cc1OC ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH+](Cc1ccc(C(=O)N(C)C)cc1)Cc1nc(C)no1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](NC(=O)c1ccc2c(c1)OCO2)C(=O)N1CCC2(CC1)[NH2+]CCC1=NC=N[C@H]12 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1=C(C(=O)N/N=C/c2cccc(Br)c2)[C@H](c2ccc([N+](=O)[O-])cc2)NC(=S)N1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H](NC(NCc2cccc(NC(=O)C)c2)=O)C[C@H](CC1)CC ### Response: CC[C@H]1CCC[C@@H](NC(=O)NCc2cccc(NC(C)=O)c2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]O[C@H](C)C[4*] Fragment 2: [5*]Nc1ccc2nnc([14*])n2n1 ### Response: Cc1ccc(O[C@H](C)CNc2ccc3nnc(C(F)(F)F)n3n2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(N2CCC(C(=O)N3CCCCC3)CC2)nc2cc3c(cc12)CCC3 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12nnc(C)n2nc(cc1)N[C@H](C(=O)N1CCCCC1)Cc1ccccc1 ### Response: Cc1nnc2ccc(N[C@@H](Cc3ccccc3)C(=O)N3CCCCC3)nn12
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(Cc1ccncc1)C1CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a thiol group? CC[N+](CC)(CC)CCOC(=O)N1CCCCC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1occc1C(=O)N1C[C@H](O)C[C@@H]1c1cc(F)ccc1F ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(Cl)cc1NC(=O)C[C@H]1Cn2nc(C)nc2NC1=O ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccsc1C(=O)N1CCN(C(=O)OC(C)(C)C)C[C@@H]1C(=O)[O-] ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1cc(F)cc(OC)c1 Fragment 2: [1*]C(=O)C[8*] ### Response: COc1cc(F)cc(CNC(=O)Cn2ccnc2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(CCC[C@H]1c1nc(on1)CC)c1c2cc(ccc2ncn1)F ### Response: CCc1nc([C@@H]2CCCN(c3ncnc4ccc(F)cc34)C2)no1
functional_group
### Instruction: Does the molecule contain a amine group? C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1CCC[C@@H]1[15*] Fragment 2: [5*]NCc1ccc(S(C)(=O)=O)cc1 ### Response: CC(C)CC[C@H]1CCC[C@H]1NC(=O)NCc1ccc(S(C)(=O)=O)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)C(=O)N1C(=O)[C@@]2(c3ccccc31)c1[nH]c3ccccc3c1CCN2C(=O)C(C)C ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)[C@@H]1CCCN(C(=O)c2c(C(C)C)nn(-c3ccc(C)cc3)c2C(C)C)C1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccccc1C(=O)N[C@]1(C(F)(F)F)N=C(c2ccccc2)N(Cc2ccco2)C1=O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN([5*])CC1 Fragment 2: [12*]S(=O)(=O)c1cccs1 ### Response: O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(OCCCn2c(C)nc([N+](=O)[O-])c2Br)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])c1nc2c(F)cccc2s1 Fragment 2: [14*]c1nc2c(F)cccc2s1 ### Response: C[NH+](C)CCN(C(=O)/C=C\c1ccc([N+](=O)[O-])cc1)c1nc2c(F)cccc2s1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)C[C@H]1[C@H]2C[C@H](C)CC=C2C(C#N)=C(N)C1(C#N)C#N ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(C)=O Fragment 2: [1*]C(C)=O ### Response: CC(=O)O[C@]1(C(C)=O)C[C@@H](O)[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C