task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COCc1ccccc1Cl)N1CCN(c2ncccn2)CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C([NH2+]C[C@@H]1CCCO1)(C)C)[O-] ### Response: CC(C)([NH2+]C[C@@H]1CCCO1)C(=O)[O-]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]([8*])O Fragment 2: [5*]Nc1ncc(Cl)cc1F ### Response: O[C@H](CNc1ncc(Cl)cc1F)C1CCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1c(CC)nn(C)c1OC Fragment 2: [5*]Nc1cc2ccccc2c(Cl)n1 ### Response: CCc1nn(C)c(OC)c1CNc1cc2ccccc2c(Cl)n1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](NC(=O)CCc1ccco1)c1ccc(-n2ccnc2)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](C)C(=O)OC Fragment 2: [8*]CC=C ### Response: C=CCn1c(S[C@@H](C)C(=O)OC)nnc1[C@H]1COc2ccccc2O1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N(CC)S(c1cc(C(NC2(CC2)c2ccc(Br)cc2)=O)ccc1)(=O)=O)C ### Response: CCN(CC)S(=O)(=O)c1cccc(C(=O)NC2(c3ccc(Br)cc3)CC2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[NH+](CC(N)=O)CC(=O)N1CCC(Cc2ccccc2)CC1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C[NH2+][C@H](c1ccc(c(c1)F)Br)Cc1ncccc1C ### Response: C[NH2+][C@@H](Cc1ncccc1C)c1ccc(Br)c(F)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCOc1ccccc1NC(=O)[C@@H]1C=C(c2ccccn2)N=N1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? CC(C)OC(=O)C[NH+]1CCC[C@@H]1c1cccc(N(C)C)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](C)c1ccc(CC)o1 Fragment 2: [14*]c1ccc(CC)o1 ### Response: CCc1ccc([C@H](C)[NH2+][C@H](C)c2nc3ccccc3n2C(C)C)o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+]1CCN(c2ncnc(NCCCN3CCOCC3)c2N)CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(Nc1cccc(c1)S(=O)(N(C)c1ccccc1)=O)c1sc(C)cc1 ### Response: Cc1ccc(C(=O)Nc2cccc(S(=O)(=O)N(C)c3ccccc3)c2)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CS(=O)(=O)CCNC(=O)CCn1cnc2ccccc2c1=O ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? CN(C(=O)N[C@](C)(C(=O)[O-])C(F)(F)F)[C@@H]1CCC[NH+](C)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1c(N)cc(Cl)cc1Cl Fragment 2: [5*][N-]c1nc(C)cc(C)n1 ### Response: Cc1cc(C)nc([N-]S(=O)(=O)c2c(N)cc(Cl)cc2Cl)n1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1C[C@@H](c2ccc(Cl)cc2)CC2=C1[C@@H](c1ccccn1)Nc1ccccc1N2 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCn1c(-c2ccc3c(c2)OCCO3)cnc1S[C@@H](C#N)Cc1ccc(C)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CS(=O)(=O)c1ccc(C(=O)Nc2nnc(SCc3ccc(Cl)cc3)s2)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccccc1Oc1ccc(CNC(=O)N(C)C2CCC2)cn1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]O[C@H]([8*])C Fragment 2: [13*][C@H]1CCCO1 ### Response: C[C@H](NC(=O)c1ccoc1)C(=O)O[C@@H](C)[C@H]1CCCO1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC1CC1 Fragment 2: [11*]Sc1ccc(N)cc1Cl ### Response: C[C@H](Sc1ccc(N)cc1Cl)C(=O)NC1CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CN(Cc2cnc3cnccn23)[C@H](c2ccccc2)CO1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(-c2ccc(c3c2cccc3)OC)[nH]cc1C(=O)OC ### Response: COC(=O)c1c[nH]c(-c2ccc(OC)c3ccccc23)n1
functional_group
### Instruction: Does the molecule contain a ester group? CC(C)(C)OC(=O)N1CCN(S(=O)(=O)C2CN(C(=O)C[C@@H]3C=CCC3)C2)CC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]COC Fragment 2: [15*][C@]1(O)CC[C@@H](C)C[C@H]1C ### Response: COC[C@]1(O)CC[C@@H](C)C[C@H]1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CN1C(=O)[C@]2(N[C@@H]([13*])[C@H]3C(=O)N(C)C(=O)[C@H]32)c2ccccc21 Fragment 2: [8*]CC(C)C ### Response: CC(C)C[C@@H]1N[C@]2(C(=O)N(Cc3ccccc3F)c3ccccc32)[C@@H]2C(=O)N(C)C(=O)[C@H]12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1C(=O)NC(=S)Nc1cccc(OCC(C)C)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccc(C(=O)N2CCC[C@@H](c3ccc(C(=O)N4CCN(C)CC4)cn3)C2)cn1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccncc1NC(=O)N1CCN(CC(=O)N2CCCCC2)CC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C=CCOc1ccc(C(=O)N[C@@H]2C[C@@H]2C)cc1OC ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+]CC[8*] Fragment 2: [4*]CCc1ccc(O)cc1 ### Response: Oc1ccc(CC[NH2+]C[C@H](c2ccc(O)cc2)C2(O)CCCCC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1c[nH]c2ccccc12 Fragment 2: [7*]C(C#N)C(=O)C(C)(C)C ### Response: CC(C)(C)C(=O)/C(C#N)=C/c1c[nH]c2ccccc12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C#CCN1CCN([C@@H](C)c2cccc([N+](=O)[O-])c2)CC1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)[C@H]1CC(=O)Nc2cc(F)ccc21 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc2cc(C(/C=C/c3cn(CC)nc3)=O)ccc21 ### Response: CCn1cc(/C=C/C(=O)c2ccc3ccccc3c2)cn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1oc(C(=O)OC[C@H]2CC=CCC2)cc1S(=O)(=O)N1CCCC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1ccccc1C(=O)N(Cc1ccc(-c2cccc(Cl)c2)o1)[C@H]1CCS(=O)(=O)C1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)Nc1nc(CC(=O)Nc2nc3c(C)cccc3s2)cs1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NS(=O)(=O)c1ccc([N+](=O)[O-])cc1 Fragment 2: [4*][C@H](C)[C@H]1CCCO1 ### Response: C[C@@H](NS(=O)(=O)c1ccc([N+](=O)[O-])cc1)[C@H]1CCCO1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC[C@H](C)C[C@@H](C)O Fragment 2: [4*]C[C@H](C)C[C@@H](C)O ### Response: C[C@@H](CNC(=O)N[C@@H]1CCN(c2ccc(Cl)cc2)C1=O)C[C@@H](C)O
canonicalization
### Instruction: Canonicalize the following SMILES string. N(CC(F)(F)F)C([C@H]1CCCN(C1)C([C@@H](OCC)C)=O)=O ### Response: CCO[C@@H](C)C(=O)N1CCC[C@H](C(=O)NCC(F)(F)F)C1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H]1CCC[C@H](NC(=O)C(=O)NCC[NH3+])C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(N)cc(C)c1S(=O)(=O)N1CCCC[C@H]1CO ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(CCN(C1)C(C)=O)C(=O)C(Nc1cc(ccc1)Br)=O ### Response: CC(=O)N1CCN(C(=O)C(=O)Nc2cccc(Br)c2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@@H](C[C@@]2(O1)CSCC2)[NH2+][C@@H](C1CC1)c1ccc(cc1)C ### Response: Cc1ccc([C@@H]([NH2+][C@H]2CCO[C@]3(CCSC3)C2)C2CC2)cc1
functional_group
### Instruction: Does the molecule contain a ketone group? CCCCN(CCO)C(=O)N[C@@H]1c2cccc(F)c2CC[C@H]1C ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c2cc(ccc2c(=O)n2CCCCCCc12)C(N[C@H](c1c(OC)ccc(OC)c1)C)=O ### Response: COc1ccc(OC)c([C@H](C)NC(=O)c2ccc3c(=O)n4c(nc3c2)CCCCCC4)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C[C@@H](CNc1ccc([N+](=O)[O-])nc1)C(=O)[O-] ### Response: 5
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(CNc2cc(C)nc3nc(-c4ccco4)nn23)c1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C/C(=C/CC[NH3+])c1ccc(Cl)cc1F ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [5*]NCC1CCOCC1 ### Response: O=C(NCC1CCOCC1)[C@H]1CC(C(c2ccccc2)c2ccccc2)=NO1
functional_group
### Instruction: Does the molecule contain a ether group? CC(C)(CNC(=O)N1CCC(OC2CCCC2)CC1)c1ccncc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. Brc1c2OCOc2cc(c1)C[NH2+]Cc1ccc(F)cc1 ### Response: Fc1ccc(C[NH2+]Cc2cc(Br)c3c(c2)OCO3)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1OCCN(Cc2cccc(F)c2Cl)[C@H]1C ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1)[C@@H]1N(C(=O)c2oc3c(c(C)cc(c3)C)c(=O)c12)Cc1occc1 ### Response: Cc1cc(C)c2c(=O)c3c(oc2c1)C(=O)N(Cc1ccco1)[C@H]3c1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)N1CCOC[C@@H]1[13*] Fragment 2: [5*]N1CCOC[C@@H]1[13*] ### Response: Cc1ncsc1CCNC(=O)C[C@H]1COCCN1C(=O)N1CCCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)n2cc(CN3C[C@@H](C)C[C@H]([NH3+])C3)nc2n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Clc1ccc([C@H](NCCc2nnc3ccccn23)C2CC2)cc1Cl ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C([C@@H]([NH+]1CCC[C@@H]1[C@@H]1CCCN1C(=O)C)C)NCC=C ### Response: C=CCNC(=O)[C@H](C)[NH+]1CCC[C@@H]1[C@@H]1CCCN1C(C)=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC[C@@H](O)CN(C)C(=O)c1ncoc1-c1ccc(C)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1csc([14*])n1 Fragment 2: [8*]Cn1ccc([16*])c1 ### Response: CCCc1nc(Cn2ccc([C@H](O)CC)c2)cs1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C=Nc1ccc2c(c1)O[C@@H](F)C(F)(F)O2 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? C[C@H](SCC[NH3+])c1ccc(C(=O)[O-])o1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCOc1ccccc1/C=C1\C(=O)NN(c2cccc(Br)c2)C1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a ester group? Cn1cc(CN2CCC[C@H]2C(=O)OC(C)(C)C)c(=O)n(C)c1=O ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? CC(=O)c1cccc(NC(=O)[C@@H]2Oc3ccccc3O[C@H]2C)c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CS[C@@H]1CC[C@@H](NC(=O)N[C@@H]2CCCc3ccccc32)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[C@H](CO)C1 Fragment 2: [16*]c1c(C)cccc1C ### Response: Cc1cccc(C)c1N1CC[C@H](CO)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1[C@@H](NC(=O)[C@@H](C)NC(=O)c1ccoc1)C(C)(C)C ### Response: 3
functional_group
### Instruction: Does the molecule contain a ester group? Cc1cc(OC(=O)[C@@H](C)Sc2nncn2C)cc(C(C)C)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Nc1cc(ccc1)NC(=O)CCc1nncn1C)(=O)c1c(cccc1)OC ### Response: COc1ccccc1C(=O)Nc1cccc(NC(=O)CCc2nncn2C)c1
functional_group
### Instruction: Does the molecule contain a amide group? C=C(C)C(=O)N[C@H](C)c1nc2ccccc2n1CCC(=O)N1CCCCCC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@@]([NH+]1CCCCC1)(C)[C@H](c1ccccc1)N)C ### Response: CC[C@@](C)([C@@H](N)c1ccccc1)[NH+]1CCCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NS(=O)(=O)c1cc([14*])n(C)c1 Fragment 2: [16*]c1cccc(C#N)c1 ### Response: Cn1cc(S(=O)(=O)Nc2cccc(C#N)c2)cc1C(N)=O
functional_group
### Instruction: Does the molecule contain a amine group? CCOC(=O)C1=C(C)N(C)C(=S)N(C)[C@H]1c1ccccc1C(F)(F)F ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: C[C@H]1CC[C@H](N2CCN(C(=O)C(=O)N3CCOCC3)CC2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CS[C@@H]1CC[C@@H](NC(=O)c2cc(C(C)(C)C)on2)C1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a thiol group? CCN(C(=O)CSc1nncn1C1CC1)[C@@H]1CCS(=O)(=O)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC(C)[NH+]1CCN(CC(=O)Nc2ccccc2Br)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? Cc1n[nH]c(C)c1[C@@H]1CCCN1C(=O)N[C@@H](C)Cn1cncn1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1sc(NC(=O)c2ccncc2F)c(C(N)=O)c1-c1ccccc1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1CCN(CCCN2C(=O)CNC2=O)c2ccccc21 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccc(OC)c1 Fragment 2: [5*]N[C@@H]1CCC[NH+]([5*])C1 ### Response: COc1cccc(C[NH+]2CCC[C@@H](NC(=O)c3c[nH]nc3C3CCCCC3)C2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cccc2cc(CN3CC[C@@H](c4cc(C(=O)NCCO)c5ccccc5n4)C3)oc12 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1ccc([C@@H](C)NC(=O)[C@H](C)[NH+]2CCc3n[nH]cc3C2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)Oc1ccc2c(C(=O)Nc3ccccc3Cl)cc(=O)oc2c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)C[C@@H]1CN(Cc2ccc3ccccc3n2)CCO1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCC(=O)/N=C1\S[C@@H]2CS(=O)(=O)C[C@@H]2N1c1ccc(Cl)cc1 ### Response: 4
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(-c2noc(CCC(=O)Nc3ccccc3SC(F)F)n2)cc1F ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@@H](CO)NC(=O)N[C@@H](C)c1ccccc1Br ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-c2nn(C)cc2C[NH2+]C(C)(C)C)cc1F ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)c1ccc(N2CC[NH+]([C@H]3CCC[C@@H](C)C3)CC2)cc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a halide group? O=C(C1CC1)N1CCc2cc(Br)c(S(=O)(=O)N3CCc4ccccc43)cc21 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccccc1)-c1n[nH]c(CN(c2ncccn2)C)c1 ### Response: CN(Cc1cc(-c2ccccc2)n[nH]1)c1ncccn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [5*]N(C)C ### Response: Cc1ccc(CN(C)C(=O)CN2CCC[NH+](CC(=O)N(C)C)CC2)o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C(=O)C(=O)Nc2cncc(-c3nnc([S-])n3C)c2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1ccccc1COc1cccc(c1)CC(=O)N(Cc1sccn1)C ### Response: Cc1ccccc1COc1cccc(CC(=O)N(C)Cc2nccs2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cccc1[14*] Fragment 2: [5*][NH+]1CCC([15*])CC1 ### Response: COC(=O)c1cccn1C1CC[NH+](Cc2cccc(-c3cnn(C)c3)c2)CC1