task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(NCc1nn(C)cn1)=O)c1c(ccc(Cl)c1)N1CCOCC1 ### Response: Cn1cnc(CNC(=O)Nc2cc(Cl)ccc2N2CCOCC2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(CC(C)C)sc1C(=O)N(c1ccc(C#N)cc1)C1CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Oc1ccc2c(sc(NC(CC)CC)n2)c1)C ### Response: CCOc1ccc2nc(NC(CC)CC)sc2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C([C@@H](CC#C)NC(CCc1oc(cc1)C)=O)N ### Response: C#CC[C@@H](NC(=O)CCc1ccc(C)o1)C(N)=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCn1cc(C(=O)NC[C@H](c2ccc(C)cc2)N2CCOCC2)c(=O)c2ccc(C)nc21 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1N=C(N2CCOCC2)S/C1=C\c1cccc(O)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cnc(-n2ncnc2)c1)NC(=O)N1CC[C@H](C(N)=O)C1 ### Response: NC(=O)[C@H]1CCN(C(=O)Nc2ccc(-n3cncn3)nc2)C1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCc1nc([C@@H]2CCCN2Cc2nc(Cc3ccccc3)no2)no1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(SCC(=O)N/N=C/c2cc(Br)ccc2O)nnc1-c1cccc(Cl)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc([C@@H](O)CCNC(=O)c2ccccc2Br)c(C)o1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? NC(=O)c1cc(NC(=O)c2ccc(-c3ccccc3F)o2)ccc1Cl ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c(ccc1)[nH]c1c(cccc1)c(=O)c2=O ### Response: O=c1c(=O)c2ccccc2[nH]c2ccccc12
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Nc1cc2COCc2cc1)(=O)/C=C/c1ccc(o1)C ### Response: Cc1ccc(/C=C/C(=O)Nc2ccc3c(c2)COC3)o1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(OC)c([C@H]2CCC[NH+]2Cn2ncn(C)c2=S)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@@H]1[C@H](C)CCCN1C(=O)N[C@@H](C)c1ncc(C)s1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COCCCC(=O)N1CCC[C@@H](c2nc3ccccc3n2C(C)C)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C=CCN(C(C)=O)Cc1nc(COc2cccc(C)c2)sc1 ### Response: C=CCN(Cc1csc(COc2cccc(C)c2)n1)C(C)=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(COc1ccc([N+](=O)[O-])cc1Br)NCC1CC1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1CC[C@H]([NH2+]Cc2cc(Cl)ccc2[N+](=O)[O-])C[C@@H]1C ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOC[C@H](O)CSC1COC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccncc1 Fragment 2: [5*]NCc1cc(OC)ccc1OC ### Response: COc1ccc(OC)c(CNC(=O)c2cc(-c3ccncc3)nc3ccccc23)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nc2sc(C(=O)Nc3ccccc3)c(N)c2c(C)c1[N+](=O)[O-] ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [11*]Sc1cc([14*])nc(C)n1 ### Response: Cc1ccc(C)c(NC(=O)CSc2cc(-c3ccccn3)nc(C)n2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(OCCOc2ccccc2)c(C(=O)[O-])n1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1[C@@H](CCC1)C(=O)NC)NC[C@@H](c1cc(c(F)cc1)F)C ### Response: CNC(=O)[C@@H]1CCCN1C(=O)NC[C@H](C)c1ccc(F)c(F)c1
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1cc(C)c([N+](=O)[O-])c(C)c1C(=O)N[C@@H]1CCC[C@@H]2OCC[C@@H]21 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1c([C@@H](C)N[C@@H](c2ccccc2)c2n[nH]c(C)n2)nc2ccccc21 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2c(c1C)[C@@H]([NH2+][C@H](CO)c1cc(F)c(F)c(F)c1)CCO2 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. n1ccsc1N1[C@H](c2c(C1=O)oc1c(cc(Cl)cc1)c2=O)c1ccc(cc1)OCC=C ### Response: C=CCOc1ccc([C@H]2c3c(oc4ccc(Cl)cc4c3=O)C(=O)N2c2nccs2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCCN1CCN(C(=O)c2cc(C)n(-c3ccccn3)c2C)CC1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(F)c(C)cc1F Fragment 2: [6*]C(=O)c1cc(F)c(C)cc1F ### Response: Cc1cc(F)c(C(=O)c2cccc(C)c2N)cc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccncc1Cl Fragment 2: [1*]C(=O)N[5*] ### Response: CC(C)(C)OC(=O)NC[C@](C)(NC(=O)c1ccncc1Cl)C1CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. CCOCC(=O)N1CCC[C@H]1c1cccc(c1)Cl ### Response: CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc([C@@H]2C(C(=O)c3ccc4c(c3)C[C@H](C)O4)=C([O-])C(=O)N2CCCn2cc[nH+]c2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(C)=O Fragment 2: [1*]C(=O)[C@H]1CC(=O)N([10*])C1 ### Response: COc1ccc(N2C[C@@H](C(=O)Nc3cccc(C(C)=O)c3)CC2=O)cc1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCn1nc(C)c(CNC(=O)CCCc2cc(C)sc2C)c1C ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1c2cc(ccc2N([C@H]1C(=O)NCCc1occc1)C(=O)C)S(=O)(=O)N1CCCCCC1 ### Response: CC(=O)N1c2ccc(S(=O)(=O)N3CCCCCC3)cc2C[C@@H]1C(=O)NCCc1ccco1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(C)C(=O)NC(=O)c1c(NC(=O)c2ccc(-c3ccccc3)cc2)sc2c1CCC2 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C(=O)c1ccc(cc1)S(=O)(=O)NC1CC[NH+](C2CC2)CC1)C ### Response: COC(=O)c1ccc(S(=O)(=O)NC2CC[NH+](C3CC3)CC2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc2n(n1)C[C@@H](Nc1nc3c(cnn3C(C)(C)C)c(=O)[nH]1)CC2 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)=C[C@@H]1[C@@H](C(=O)N2CCC(Oc3ccnc(C(N)=O)c3)CC2)C1(C)C ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCn1nc(C)c(NC(=O)N[C@H](c2nc(C)no2)C(C)C)c1C ### Response: 3
functional_group
### Instruction: Does the molecule contain a ketone group? CC(=O)c1cccc(C[NH+]2CC[C@]3(CCC[NH+](Cc4cccc(C)c4)C3)C2)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C=CCC[C@H]([NH+]1CCN(CC1)c1ncnc2c1ccs2)C ### Response: C=CCC[C@@H](C)[NH+]1CCN(c2ncnc3sccc23)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccn(C)n1 Fragment 2: [5*]N1CCC([15*])CC1 ### Response: CN(C(=O)c1ccn(C)n1)[C@H](Cc1ccccc1)C1CCN(C(=O)C2=CCCC2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CCN1C[C@H](C[C@@H](C1)[NH3+])C)(Nc1cccc(F)c1)=O ### Response: C[C@H]1C[C@H]([NH3+])CN(CCC(=O)Nc2cccc(F)c2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C#CCOc1ccccc1CN(C)C(=O)Nc1nnc(-c2ccsc2)s1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1nc(CCCNc2ccc(Cl)cc2)cs1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(c1c(F)c(C(CC2CCCC2)=O)ccc1)(F)F ### Response: O=C(CC1CCCC1)c1cccc(C(F)(F)F)c1F
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cccc1OCc1nsnc1C)C(=O)N[C@@H]1CCS(C1)(=O)=O ### Response: Cc1nsnc1COc1cccc(C(=O)N[C@@H]2CCS(=O)(=O)C2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(OC)cc1 Fragment 2: [16*]c1ccccc1 ### Response: COc1ccc(NC(=O)NCc2nc(-c3ccccc3)cs2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)Nc1ccc(Cl)c(NC(=O)N2C[C@@H](C)O[C@H](C)C2)c1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? O=C(Cn1ccnc1)N[C@H](c1ccccc1)c1ccc(Cl)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? CCn1c(CN2C[C@@H](C)OC[C@@H]2C)nc2ccccc21 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc2O[C@@H](c3n(c(S[C@H](C(=O)OC)C)nn3)CC=C)COc2c1 ### Response: C=CCn1c(S[C@@H](C)C(=O)OC)nnc1[C@H]1COc2ccccc2O1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(OC)cc(cc1OC)-c1nccnc1N ### Response: COc1cc(OC)cc(-c2nccnc2N)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCC[C@@H]1[13*] Fragment 2: [4*]CCCOC ### Response: CCn1c([C@H]2CCC[NH+]2CCCOC)nc2ccccc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1CCCN1c1ccc(S(=O)(=O)N(Cc2cccs2)Cc2cccs2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@H]1CC(=O)NC1=O Fragment 2: [11*]SCC ### Response: CCSC[C@@H](C)N(C)C(=O)c1ccc(C[C@H]2CC(=O)NC2=O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CS(=O)(=O)c1nc([14*])cs1 Fragment 2: [16*]c1ccccc1 ### Response: O=S(=O)(Cc1coc(-c2ccccc2)n1)c1nc(-c2ccccc2)cs1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC[C@@H](NC(=O)Nc1ccc(C)nc1Cl)c1ccc(F)c(F)c1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC[C@@H]([8*])CCO Fragment 2: [16*]c1ccccc1 ### Response: Cc1cc(C(=O)NC[C@H](CCO)c2ccccc2)nn1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc([14*])o1 Fragment 2: [4*][C@@H](C)c1ccc([14*])o1 ### Response: COc1ccccc1C[NH+](C)[C@@H](C)c1ccc(C(=O)[O-])o1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1NC(COCC)=O)Oc1cc(ccc1)C ### Response: CCOCC(=O)Nc1ccc(Oc2cccc(C)c2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccccc1[C@H]1C[C@@H]1NC(=O)N1CCC[C@H](O)C1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)C(=O)COC(=O)CCc1nc2ccccc2[nH]c1=O ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)n2nc(SCC(=O)N3CCC(C(=O)[O-])CC3)nc2n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)N1c2ccc(S(=O)(=O)N3CCCC3)cc2C[C@H]1C(=O)NCC[NH+](C)C1CCCCC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cnn(CC)c1 Fragment 2: [1*]C(=O)C1CCN([5*])CC1 ### Response: CCn1cc(NC(=O)C2CCN(C(=O)c3ccc([N+](=O)[O-])cc3)CC2)cn1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(OCCOC(C)C)CC[C@H](C1)[NH2+]C ### Response: C[NH2+][C@@H]1CC[C@@H](OCCOC(C)C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CCCCO)N1CCC[C@H](CO)C1 ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC1=NN=C(c2ccc(N[5*])cc2)CS1 Fragment 2: [1*]C(C)=O ### Response: CC(=O)Nc1ccc(C2=NN=C(NCc3ccc(F)cc3)SC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC1c2ccccc2-c2ccccc21 Fragment 2: [1*]C(=O)C[8*] ### Response: Cc1nc(CC(=O)OC2c3ccccc3-c3ccccc32)cs1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)[C@](C)(N)C(F)(F)F)c(C)n1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccc(CNC(=O)c2ncn3c2C(=O)N(C2CC2)[C@](C)(C(=O)NCc2ccc(C)cc2)C3)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[C@@H](NC(=O)c1ccc(-n2ccnn2)cc1)c1nc(C2CC2)no1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C12C(C3CC(CC(C3)C2)C1)C(=O)NCCC(NC(=O)N)=O ### Response: NC(=O)NC(=O)CCNC(=O)C1C2CC3CC(C2)CC1C3
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCN(C(=O)c1cc(Cl)ccc1O)C1CCC([NH3+])CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? O=C1CS[C@H](c2ccccc2)N1c1ccccc1F ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc([C@@H](C)[NH2+]CC2(CO)CCOCC2)cc1F ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](c1ccc(S(C)(=O)=O)cc1)N(C)c1ccc2ccc(F)cc2n1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? O=C1Oc2ccccc2[C@@H]2[C@@]1(C(=O)N1CCOCC1)[C@]21Cc2ccccc2C1=O ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cnccc1-c1nnc(n1-c1ccc(Cl)c(Cl)c1)S[C@H]1CCCCC1=O ### Response: O=C1CCCC[C@@H]1Sc1nnc(-c2ccncc2)n1-c1ccc(Cl)c(Cl)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. S1(=O)(=O)CC[C@H](C1)n1c(c(c(n1)C)N1CCN(CC1)CC(=O)NCCc1ccccc1)C ### Response: Cc1nn([C@@H]2CCS(=O)(=O)C2)c(C)c1N1CCN(CC(=O)NCCc2ccccc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCN(Cc1cccc(F)c1Cl)S(=O)(=O)N1CCCCC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)Oc1cc(ccc1OC)[C@H]1c2c(n(-c3nncc(n3)-c3ccc(F)cc3)nc2C)NC(=O)C1 ### Response: CCOc1cc([C@@H]2CC(=O)Nc3c2c(C)nn3-c2nncc(-c3ccc(F)cc3)n2)ccc1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(c1Cl)NC([C@@H](n1c(c(NC(C)=O)cc(n1)-c1ccc(cc1)CC)=O)C)=O ### Response: CCc1ccc(-c2cc(NC(C)=O)c(=O)n([C@@H](C)C(=O)Nc3ccccc3Cl)n2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H]1NC(=O)[C@H](C)N(c2cccnc2C)C1=O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(F)c(F)c(F)c1 Fragment 2: [1*]C(=O)[C@H]1CCC[NH2+][C@H]1C ### Response: C[C@@H]1[NH2+]CCC[C@@H]1C(=O)Nc1cc(F)c(F)c(F)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]1CCCO1 Fragment 2: [4*]CC1CC[NH+]([5*])CC1 ### Response: O=C(c1cccc(Cl)c1)N(CC1CC[NH+](Cc2ccccc2F)CC1)C[C@H]1CCCO1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(Cl)ccc1C Fragment 2: [1*]C(=O)[C@@H]1CCN([10*])C1=O ### Response: Cc1ccc(Cl)cc1N1CC[C@@H](C(=O)Nc2ccc(F)cc2F)C1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. O(CC[C@@H]1C(CCC1)=O)CC(C)C ### Response: CC(C)COCC[C@H]1CCCC1=O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(CCCNC(=O)NNC(=O)C(C)(C)C)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)cc(N(CC(=O)NCC(C)C)S(C)(=O)=O)c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2OC3(CCCC3)Oc2ccc1NC(C(N[C@@H]1CCC[C@@H](C1)C)=O)=O ### Response: C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccc3c(c2)OC2(CCCC2)O3)C1
functional_group
### Instruction: Does the molecule contain a nitrile group? Cn1cnnc1S[C@@H]1CCN(c2sccc2C#N)C1=O ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? O=C(CNC(=O)c1ccoc1)NC1CCC([NH+]2CCCCC2)CC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1CC[C@@H](C(=O)Nc2nc(-c3ccccn3)cs2)CN1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@H]1CCC[C@H](NC(=O)c2ccc(S(=O)(=O)N(C)C)o2)C1 ### Response: Yes