task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCc2[nH]c3ccccc3c2C1 Fragment 2: [1*]C(=O)c1nc2nc(C)cc(C)n2n1 ### Response: Cc1cc(C)n2nc(C(=O)N3CCc4[nH]c5ccccc5c4C3)nc2n1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(S(Nc2cc(NC(c3cc(ccc3)CSC)=O)ccc2)(=O)=O)cc1 ### Response: CSCc1cccc(C(=O)Nc2cccc(NS(=O)(=O)c3ccccc3)c2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cnc2c(C)cccc2c1=O Fragment 2: [5*]N1CCc2sccc2[C@@H]1c1ccccc1 ### Response: Cc1cccc2c(=O)n(CCCC(=O)N3CCc4sccc4[C@@H]3c3ccccc3)cnc12
functional_group
### Instruction: Does the molecule contain a halide group? Cc1cccc(C)c1-n1nnnc1CS(=O)(=O)[C@@H](C)c1c(F)cccc1F ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1nc2n(n1)CCC[C@@H]2NC(=O)N[C@@H](c1ccccc1)C(C)(C)C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1cc(S(N)(=O)=O)ccc1Cl Fragment 2: [5*]N1C[C@@H](C)CSc2ccccc21 ### Response: C[C@H]1CSc2ccccc2N(S(=O)(=O)c2cc(S(N)(=O)=O)ccc2Cl)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N#CC1=C(N)N2C(=C(C#N)[C@H]1c1ccncc1)Nc1ccccc12 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [5*]N([5*])CC ### Response: CCN(C(=O)CCc1nc(C)no1)c1ccccc1
functional_group
### Instruction: Does the molecule contain a halide group? CCOC(=O)[C@@H](F)Oc1ccc2c(c1)CCC2 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? CCn1cc([C@H]2OCC[C@H]2C[NH2+]Cc2ccc(C)s2)cn1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H](N(CCO1)S(=O)(=O)c1ccc(CC#N)cc1)C ### Response: C[C@H]1COCCN1S(=O)(=O)c1ccc(CC#N)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Cc1nc(oc1)-c1ccccc1)(Oc1ccc(cc1)C(CC)=O)=O ### Response: CCC(=O)c1ccc(OC(=O)Cc2coc(-c3ccccc3)n2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)C(=O)/C=C/c1csc(N(C(C)=O)c2ccccc2F)n1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CCCN(C(=O)c2cn(C)nc2C(C)(C)C)[C@@H]1C ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCNC(=O)CN1CCN(Cc2nc(C(C)C)no2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CN[5*] Fragment 2: [16*]c1ccccc1 ### Response: C[C@@H](CCc1ccccc1)NC(=O)CNC(=O)c1cccc(Cl)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C)(C(=O)c1ccc(F)c(c1)NC(=O)[C@@H]1[C@@H](C1)c1ccccc1F)C ### Response: CN(C)C(=O)c1ccc(F)c(NC(=O)[C@H]2C[C@H]2c2ccccc2F)c1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H]1OCC[C@@H]1C(=O)NC[C@@H](c1ccccc1)C(C)(C)CO ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc([C@@H](C)NC(=O)CC[C@H]2NC(=O)NC2=O)cc1F ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(C)nc(NC(c2c3c(ccc(c3)C)[nH]n2)=O)s1)C(=O)OCC ### Response: CCOC(=O)c1sc(NC(=O)c2n[nH]c3ccc(C)cc23)nc1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](C(=O)N1CCC([NH2+][C@H](C)c2cccnc2)CC1)c1ccccc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [9*]n1cccc1 ### Response: Cc1cccc(NC(=O)CC2(n3cccc3)CCCCC2)n1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CN(C1CCC(C)(C)CC1)S(=O)(=O)c1c[nH]cn1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nn(C)c2c1nc([C@H](C)Cl)n2[C@@H](C[NH+](C)C)C(C)C ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1ccccc1CNC(=O)N1CCCC[C@H]1C ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(F)Sc1cccc(c1)NC(C(=O)NC[C@@H]1C[C@H](CCC1)O)=O ### Response: O=C(NC[C@H]1CCC[C@H](O)C1)C(=O)Nc1cccc(SC(F)F)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOCCN(C)C(=O)C1(CC)CCCC1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? CCCNC(=O)Cn1nc(-c2ccccc2)c2ccccc21 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)c1ccc(CN(C)C(=O)C[C@H](NC(C)=O)c2cccs2)cc1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)[C@@H](CC(C)C)NC(=O)Cc1c(C)nc(C)[nH]c1=O ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1ccc2[nH+]c(Cn3nc(-c4ccc(F)cc4)oc3=O)cn2c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC[NH+](C)CC1 Fragment 2: [5*]Nc1ccc2n(c1=O)C[C@H]1C[C@@H]2CN([5*])C1 ### Response: C[NH+]1CCC(N2C[C@@H]3C[C@H](C2)c2ccc(NC(=O)c4ccc(C#N)cc4)c(=O)n2C3)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2csc(NC(=O)c3cncnc3C)n2)cc1OC ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [8*]CCCS(=O)(=O)C[8*] ### Response: Cc1nc(CCCS(=O)(=O)Cc2nc(C3CC3)no2)cs1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [4*][C@]1(CO)CCC[C@H]([15*])C1 ### Response: CCC[NH+](CC)[C@H]1CCC[C@@](CO)([NH2+]CC)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCCN1CC[NH2+]CC1)N1CCCCCC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc([C@H](O)CNC(=O)C(=O)Nc2ccc(C)c(F)c2)o1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc2c(c1)[C@@H](CO2)C[C@@H](c1cccc(c1)Cl)CO ### Response: OC[C@@H](C[C@@H]1COc2ccccc21)c1cccc(Cl)c1
functional_group
### Instruction: Does the molecule contain a amine group? COc1ccccc1C[C@@H](NC(=O)N(C)C(C)C)C(C)C ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1cc(C)cc(O[C@@H](C(Nc2ccc(CC)cc2)=O)C)c1 ### Response: CCc1ccc(NC(=O)[C@@H](C)Oc2cc(C)cc(C)c2)cc1
functional_group
### Instruction: Does the molecule contain a halide group? COc1cccc(Nc2ncccc2C(=O)Nc2ccc(Br)cc2)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1ccsc1/C=N/NC(=O)c1ccc2[nH]cnc2c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1CCCn2nc(CC)nc21 Fragment 2: [1*]C(=O)N[C@@H]1CCCn2nc(CC)nc21 ### Response: CCc1nc2n(n1)CCC[C@H]2NC(=O)Nc1ccc(CC#N)cc1
functional_group
### Instruction: Does the molecule contain a amide group? Clc1cc(CN2CCN(c3ccccc3)CC2)cc(Cl)n1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? C[C@]1(C(=O)N2CCN3C(=O)NC[C@H]3C2)CCC[NH2+]1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ester group? COC(=O)CCN(Cc1ccccc1C#N)C(C)C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C)cc1NC(=O)C(=O)NCC1CC[NH+](Cc2cc(C)oc2C)CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)(C)NS(=O)(=O)c1ccc(C(=O)NCC2(c3cccc(Cl)c3)CCOCC2)o1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? CSCc1ccnc(NC2CCN(C(=O)c3cnccn3)CC2)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(Cl)c(N[5*])c1 Fragment 2: [16*]c1ccc(Br)cc1 ### Response: CCCC(=O)Nc1ccc(Cl)c(NC(=O)COc2ccc(Br)cc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1cc(CSCc2nnc(C)n2C)oc1C ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCCC1NC(N1CCO[C@@H](C1)C#N)=[NH2+] ### Response: N#C[C@@H]1CN(C(=[NH2+])NC2CCCCC2)CCO1
functional_group
### Instruction: Does the molecule contain a amine group? O=C1C[C@H](C(=O)Nc2ccc(Br)cc2)C2(CCCCC2)O1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)(C)NS(c1cc(c(cc1)OC)NC(=O)/C=C/C1CC1)(=O)=O ### Response: COc1ccc(S(=O)(=O)NC(C)(C)C)cc1NC(=O)/C=C/C1CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)[C@@H]1C(=O)N=C(N2CCN(c3ncccn3)CC2)N[C@H]1c1ccco1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)S(=O)(=O)c1cc(NC(=O)/C=C/c2ccco2)ccc1C ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/C=C(/C)C(=O)NC[C@H]1CCC[NH+](Cc2cccs2)C1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@]1(CNC(=O)C[C@H]2CCCC[C@@H]2[NH3+])CCCO1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]12CS(=O)(=O)C[C@@H]1N/C(S2)=N\c1ccc(CC(NCCC2=CCCCC2)=O)cc1 ### Response: O=C(Cc1ccc(/N=C2\N[C@H]3CS(=O)(=O)C[C@@H]3S2)cc1)NCCC1=CCCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc2c(c1)OCCO2 Fragment 2: [5*]N[C@H]([8*])C ### Response: C[C@H](NCC(=O)N[C@H](C)c1ccc2c(c1)CCCC2)c1ccc2c(c1)OCCO2
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1oc(nc1C#N)COc1ccccc1)[C@@H](c1ccccc1)C ### Response: C[C@@H](Nc1oc(COc2ccccc2)nc1C#N)c1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)NC[C@@H]1COCCO1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(CO[C@@H]2C[NH+](CC(=O)N(C2)Cc2cccnc2)Cc2c(nn(c2)C)C)c1 ### Response: Cc1nn(C)cc1C[NH+]1CC(=O)N(Cc2cccnc2)C[C@H](OCc2ccccc2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OCC[C@@H](C[NH3+])c2ccc(C)cc2)ccccc1 ### Response: Cc1ccc([C@H](C[NH3+])CCOc2ccccc2)cc1
functional_group
### Instruction: Does the molecule contain a nitrile group? COc1cc(F)cc(CNC(=O)CCc2nc[nH]n2)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C1N[C@@H](N(C)c2nc(C)ccc12)c1ccc(cc1)NC([C@H]1CC=CCC1)=O ### Response: Cc1ccc2c(n1)N(C)[C@@H](c1ccc(NC(=O)[C@H]3CC=CCC3)cc1)NC2=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccccc1[16*] Fragment 2: [1*]C(=O)C[4*] ### Response: O=C(COc1ccccc1-c1noc(-c2ccc(Cl)cc2)n1)N1CCCC1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cc(=O)[nH]c(-c2cccc(CN3CCN(c4cccc(C)[nH+]4)CC3)c2)n1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [9*]n1nc([14*])ccc1=O ### Response: CCOc1ccccc1NC(=O)Cn1nc(-c2cccc(Br)c2)ccc1=O
functional_group
### Instruction: Does the molecule contain a amide group? CCC(CC)c1nnc(NC(=O)[C@@H](C)NC(N)=O)s1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C)N1c2ccc(NC(=O)c3sc([C@H]4OCCC4)nc3)cc2CC1 ### Response: CC(=O)N1CCc2cc(NC(=O)c3cnc([C@@H]4CCCO4)s3)ccc21
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COC1CC[NH+](CCNC(=O)C(=O)Nc2cnc(-c3ccccc3)s2)CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O=C([O-])CCCCC(=O)N1CCC(CO)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O[C@]([C@H](C)CC)(C)CNC(Cc1ccc(C)c(c1)O)=O ### Response: CC[C@@H](C)[C@](C)(O)CNC(=O)Cc1ccc(C)c(O)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1c(C(=O)NCCOc2ccccc2)cc2cnc3[nH]ccc3c21 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(-n2ccc(C(=O)N(C)[C@@H](C)CC#N)n2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1c(cccc1)[C@@H]1CCCN1C(NCCN1CCOCC1)=O)C ### Response: COc1ccccc1[C@@H]1CCCN1C(=O)NCCN1CCOCC1
functional_group
### Instruction: Does the molecule contain a ester group? CNc1ccccc1C(=O)N[C@@H]1C[C@@H](C(=O)OC)N(C)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cn2cc(C)ccc2[nH+]1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: Cc1ccc2[nH+]c(CN3CCN(C(=O)C4CCCC4)CC3)cn2c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCSc1ncc(CN2CCc3[nH]c[nH+]c3[C@H]2c2ccc(Cl)nc2)cn1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(NC(=O)Cc2cc(-c3ccccc3F)on2)c2ccccc2n1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(C)cc1NC(=O)C[C@H]1CSc2nc(C(C)C)cc(=O)n21 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? COCc1nc(C)c(C(=O)NCC2(C)Cc3ccccc3C2)s1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc(C(=O)Nc2ccc(C(=O)N[C@@H](C)c3ccccc3)cc2)cc1Br ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C#CCOc1ccc2ccccc2c1CN1CCN[C@H](C(=O)N(C)C)C1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(CCNC(=O)/C(C#N)=C\C2=Cc3cc(Cl)cc(Cl)c3OC2)cc1OC ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? CCc1nn(C)cc1CNC(=O)C1(CC)CCC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Oc1ccc(/N=c2\oc3c(ncc(CO)c3cc2C(N)=O)C)cc1)(F)(F)F ### Response: Cc1ncc(CO)c2cc(C(N)=O)/c(=N/c3ccc(OC(F)(F)F)cc3)oc12
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(ccc1)Cn1c2ccccc2sc1=O)SC(=O)N(C)C ### Response: CN(C)C(=O)Sc1cccc(Cn2c(=O)sc3ccccc32)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccc([C@H](CNC(=O)c2c[nH]nc2-c2ccccc2)N2CCOCC2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)C[8*] ### Response: CCOc1ccccc1N1CCN(C(=O)Cc2cn3ccsc3n2)CC1
functional_group
### Instruction: Does the molecule contain a ether group? CC1(C)C(C(=O)N2CCO[C@H](c3ccccc3)C2)C1(C)C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccn2c(=O)c(N[5*])cnc12 Fragment 2: [5*]Nc1ccccc1 ### Response: O=C(Nc1ccccc1)Nc1cnc2c(C(=O)NCc3ccco3)cccn2c1=O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCn1cc2nc(SCC(=O)Nc3ccc(Br)cc3F)n(CC)c(=O)c2n1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1ccc([C@@H]2C(C(=O)OC)=C(N)Oc3cc(C)[nH]c(=O)c32)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](C)NC(=O)c1cnn2c3c(cnc12)C[C@H](C)CC3 ### Response: 4
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(Cc1cccc(C#N)c1)C(=O)C[C@H](O)c1cc(Cl)cc(Cl)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(-c2noc(CS(=O)(=O)[C@@H](C)[C@@H](C)O)n2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(NC(=O)c2nnn(Cc3ccc(SC)cc3)c2N)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1C[C@@H]1C Fragment 2: [14*]c1c([16*])c(C)nn1C ### Response: Cc1nn(C)c(NC(=O)N[C@@H]2C[C@@H]2C)c1-c1ccc(Br)cc1