id stringlengths 24 24 | question stringlengths 21 168 | context stringlengths 79 19.2k | answer stringclasses 2
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5a735c143b9d13c708000003 | Is patisiran currently (November 2017) in clinical phase II trials? | This review addresses nine small-interfering RNAs (siRNAs) and one unique microRNA (miRNA) inhibitor, which entered the phase 2-3 clinical trials. The siRNAs in focus are PF-04523655, TKM-080301, Atu027, SYL040012, SYL1001, siG12D-LODER (phase 2), QPI-1002, QPI-1007, and patisiran (phase 3). patisiran (phase 3) Phas... | no |
5a70e1d999e2c3af26000007 | Is Solanezumab effective for Alzheimer's Disease? | An analysis of publicly available data from the Phase II studies for bapineuzumab and solanezumab indicates that neither compound produced compelling evidence of drug-like behavior that would justify their progression into pivotal trials. Notably, a recent study of solanezumab, an amyloid β monoclonal antibody, raises... | no |
5a6fabfeb750ff4455000062 | Are there mammalian promoters with distal enhancer functions? | Genome-wide characterization of mammalian promoters with distal enhancer functions. Gene expression in mammals is precisely regulated by the combination of promoters and gene-distal regulatory regions, known as enhancers. Several studies have suggested that some promoters might have enhancer functions. However, the ext... | yes |
5a6f77d7b750ff4455000051 | Is autosomal dominant inheritanced form of Osteogenesis imperfecta caused by mutations in the genes associated with collagen production? | steogenesis imperfecta (OI) is a heterogeneous bone disorder characterized by recurrent fractures. Although most cases of OI have heterozygous mutations inCOL1A1orCOL1A2and show autosomal dominant inheritance, Osteogenesis imperfecta (OI) is a group of hereditary disorders characterized by decreased bone mass and incre... | yes |
5a8965f6fcd1d6a10c000005 | Are splicing speckles associated with transcription? | We show here that RNA splicing speckled domains (splicing speckles) fluctuate in constrained nuclear volumes and remodel their shapes. We present a model where recycling splicing factors return as part of small sub-speckles from distal sites of RNA processing to larger splicing speckles by a directed ATP-driven mechani... | no |
5a723edd2dc08e987e00000c | Is Tofacitinib effective for Ulcerative Colitis? | Tofacitinib, inhibiting signalling via all Janus kinase family members, was effective in phase 2 and 3 trials in moderate-severe ulcerative colitis. Among them, Janus kinase (JAK) inhibitors seem to have the lead, since tofacitinib has received regulatory approval in 2012 for the treatment of rheumatoid arthritis, and ... | yes |
5a893da7bc7bade53a000001 | Is CREB a key memory protein? | Human cyclic AMP response element binding protein (CREB) transcription factor which plays a crucial role in memory The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. A mouse genetic study showed that cAMP-responsive element-binding protei... | yes |
5a76080683b0d9ea66000015 | Is cilengitide effective for treatment of glioblastoma? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
5a6f829eb750ff4455000054 | Can multiple myeloma patients develop hyperviscosity syndrome? | Multiple myeloma (MM) is an immedicable malignancy of the human plasma cells producing abnormal antibodies (also referred to as paraproteins) leading to kidney problems and hyperviscosity syndrome. This skin condition may be observed in patients with the following condtions, such as primary polycythemic hyperviscosity... | yes |
5a6e3fe3b750ff4455000044 | Does the human lncRNA LINC-PINT promote tumorigenesis? | The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element. Here we characterize the function of the p53-regulated human lncRNA LINC-PINT in cancer. We find that LINC-PINT is downregulated in multiple types of cancer and acts as a tumor suppressor lncRNA by reducing the invasive... | no |
5a6e49a4b750ff445500004b | Is LDB1-mediated enhancer looping dependent on cohesin? | LDB1-mediated enhancer looping can be established independent of mediator and cohesin. Moreover, ENCODE data and our chromatin immunoprecipitation results indicate that cohesin is almost completely absent from validated and predicted LDB1-regulated erythroid enhancer-gene pairs. Thus, lineage specific factors largely m... | no |
5a6e4b72b750ff445500004c | Is there any link between ERCC1-XPF and cohesin? | ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Using an in vivo biotinylation tagging approach in mice, we show that the nucleotide excision repair (NER) structure-specific endonuclease ERCC1-XPF complex interacts with the insulator binding protein CTCF, the coh... | yes |
5a70ea8299e2c3af2600000b | Does Evolocumab improve cognitive function? | Conclusions In a randomized trial involving patients who received either evolocumab or placebo in addition to statin therapy, no significant between-group difference in cognitive function was observed over a median of 19 months. Results A total of 1204 patients were followed for a median of 19 months; the mean (±SD) c... | no |
5a72284b2dc08e987e000001 | Can radius fracture cause carpal tunnel syndrome? | Carpal tunnel syndrome (CTS) after distal radius fractures can present in 3 forms: acute, transient, and delayed. Complications were categorized as carpal tunnel syndrome, other sensibility issues, tendon complications including irritation and rupture, deep infections, complex regional pain syndrome and unidentified DR... | yes |
5a75f1f383b0d9ea66000006 | Can Logic Alignment Free (LAF) be used for bacterial genomes classification? | LAF: Logic Alignment Free and its application to bacterial genomes classification. In this paper, we present Logic Alignment Free (LAF), a method that combines alignment-free techniques and rule-based classification algorithms in order to assign biological samples to their taxa. This method searches for a minimal subse... | yes |
5a722a052dc08e987e000002 | Is Marfan syndrome associated with chordal rupture? | Repair of the mitral valve in children who have Marfan syndrome is especially difficult due to the presence of generalized connective tissue disorder, which may lead to future elongation and rupture of chordae tendineae that were unaffected at the time of mitral valve repair. Mitral regurgitation was caused by annulus ... | yes |
5a6f922fb750ff4455000059 | Can canagliflozin cause euglycemic diabetic ketoacidosis? | CASE REPORT: We present a case of a 57-year-old woman with type 2 diabetes mellitus taking a combination of canagliflozin and metformin who presented with progressive altered mental status over the previous 2 days. Her work-up demonstrated a metabolic acidosis with an anion gap of 38 and a venous serum pH of 7.08. The ... | yes |
5a68eabab750ff4455000015 | Is there an association between Klinefelter syndrome and breast cancer? | Screening for breast cancer in male-to-female transsexuals should be undertaken for those with additional risk factors (e.g., family history, BRCA2 mutation, Klinefelter syndrome) and should be available to those who desire screening, preferably in a clinical trial. Klinefelter syndrome (OR = 24.7; 95% CI = 8.94 to 68.... | yes |
5a7615af83b0d9ea6600001f | Is vorinostat effective for glioblastoma? | Conclusions: Vorinostat combined with standard chemoradiation had acceptable tolerability in newly diagnosed glioblastoma. Although the primary efficacy endpoint was not met, vorinostat sensitivity and resistance signatures could facilitate patient selection in future trials. LESSONS LEARNED: Combination regimen with b... | no |
5a773c50faa1ab7d2e000002 | Has ATF4 transcription factor been linked to cancer and neoplastic transformation? | aken together, we discovered a novel axis of BCL10-regulated OSCC progression via STAT1/ATF4/S100P/P65 signaling, which could predict the prognosis of OSCC and will be beneficial for developing therapeutic strategy against advanced OSCC s a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2α... | yes |
5a6f87c5b750ff4455000056 | Are patients with Sjogren syndrome at increased risk for lymphoma? | The heightened risk of non-Hodgkin lymphoma (NHL) development in primary Sjogren syndrome (SS) is well established. Primary Diffuse Large B-Cell Lymphoma of the Liver in a Patient with Sjogren Syndrome. Immunohistochemical and molecular features of the tumors allowed diagnosis of diffuse large B-cell lymphoma (DLBCL). ... | yes |
5a76016683b0d9ea6600000d | Down's syndrome occurs when an individual has an extra copy or part of a copy of chromosome 21, yes or no? | Down syndrome (DS; trisomy 21) is the most common survivable disorder due to aneuploidy. Down syndrome (DS), trisomy 21, is caused by increased dose of genes present on human chromosome 21 (HSA21) Down syndrome, or Trisomy 21, is the most frequently occurring chromosomal abnormality in live-born children. Down syndrom... | yes |
5a68f633b750ff4455000019 | Is creatinine assessment included in the MELD score? | Model For End-Stage Liver Disease (MELD) scores were calculated as 3.78×ln[TB] + 11.2×ln[INR] + 9.57×ln[creatinine] + 6.43. A corrected creatinine was derived from the mGFR after application of the Modification of Diet in Renal Disease formula. Subsequently, a corrected MELD was calculated and compared with the conven... | yes |
5a79d195faa1ab7d2e00000e | Is celiac disease caused by gliadin-induced transglutaminase-2 (TG2)-dependent events ? | Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Celiac disease (CD) is an autoimmune enteropathy initiated and sustained by the ingestion of gluten in genetically susceptible individuals. It is caused by a dysregulated immune response tow... | yes |
5a79d25dfaa1ab7d2e00000f | Does wheat belongs to the genus Avena, yes or no? | oat seedlings (Avena sativa) wild green-oat (Avena sativa) Oat (Avena sativa L.) Oat (Avena sativa L.) Avena (Oats) wild oats (Avena fatua L.) oats (genus Avena) Avena sativa L. and A. byzantina C. Koch) oat (Avena sativa L.). oat (Avena sativa L.) and wheat (Triticum aestivum | no |
5a6d2558b750ff4455000036 | Does Uc.160 promote cancer? | We previously discovered the downregulation of T-UCR expression in gastric cancer (GC), indicating that T-UCRs could play an important role in GC biology. Uc.160+, a T-UCR reported to be downregulated in human cancer, has not been examined in GC.METHODS: We analyzed the expression pattern of Uc.160+ in nonneoplastic an... | no |
5a69031bb750ff445500001e | Can doxycycline cause photosensitivity? | Phototoxicity of Doxycycline: A Systematic Review on Clinical Manifestations, Frequency, Cofactors, and Prevention. BACKGROUND: One of the most important dermatologic side effects of doxycycline is photosensitivity. While there are many publications on the phototoxicity of tetracyclines in general, only a few exist fo... | yes |
5a6e21b4b750ff445500003a | Are paralog genes co-regulated? | Co-regulation of paralog genes in the three-dimensional chromatin architecture. Consequently, paralogs show correlation in gene expression whereby the mechanisms of co-regulation remain unclear. In eukaryotes, genes are regulated in part by distal enhancer elements through looping interactions with gene promoters. Thes... | yes |
5a8714e261bb38fb24000005 | Is polyadenylation a process that stabilizes a protein by adding a string of Adenosine residues to the end of the molecule? | The addition of poly(A) tails to eukaryotic nuclear mRNAs promotes their stability, export to the cytoplasm and translation. Most eukaryotic genes express mRNAs with alternative polyadenylation sites at their 3' ends Polyadenylation is the non-template addition of adenosine nucleotides at the 3'-end of RNA, which occu... | no |
5aa825b1fcf4565872000003 | Are stress granules membraneous? | PMLOs are different in size, shape, and composition, and almost invariantly contain intrinsically disordered proteins (e.g., eIF4B and TDP43 in stress granules, Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA met... | no |
5aa304f1d6d6b54f79000004 | Is the consumption of chocolate associated with an increase in cardiovascular disease? | The consumption of natural polyphenol-rich foods, and cocoa in particular, has been related to a reduced risk of CVD, including coronary heart disease and stroke. chocolate has been shown to decrease CVD risk due to its antioxidant and anti-inflammatory properties. A number of studies have shown that dietary polyphenol... | no |
5a9d79ca1d1251d03b00001d | Is the gene CDKN2A nevogenic? | Germline mutations in CDKN2A are frequently identified among melanoma kindreds and are associated with increased atypical nevus counts. Phenotypic characteristics of members of a melanoma prone kindred with a V126D CDKN2A gene mutation were monitored over approximately 15 y. Rare germline mutations in CDKN2A predispos... | yes |
5a80dbaafaa1ab7d2e000026 | Are there ways of joint Bayesian inference of risk variants? | Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases. Genome wide association studies (GWAS) provide a powerful approach for uncovering disease-associated variants in human, but fine-mapping the causal variants remains a challenge. This is partly re... | yes |
5a9acba61d1251d03b000014 | Has intepirdine been evaluated in clinical trials? (November 2017) | Using small molecules blocking 5-HT6serotonin receptor (intepirdine), inhibiting BACE activity (E2609, AZD3293, and verubecestat), or reducing tau aggregation (TRx0237) are also currently in Phase III clinical trials. | yes |
5aa3fa73d6d6b54f79000008 | Is subacute sclerosing panencephalitis caused by the Measles vaccine? | Subacute sclerosing panencephalitis (SSPE) is a potentially fatal complication of measles. Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk f Subacute sclerosing panencephalitis should be eliminated by measles vaccination The ... | no |
5a76072283b0d9ea66000013 | Does armodafinil improve fatigue of glioma patients? | CONCLUSIONS: While treatment was well-tolerated, an 8-week course of armodafinil did not improve fatigue or QOL in glioma patients undergoing RT in this pilot study. We evaluated whether armodafinil, a wakefulness-promoting medication, improves fatigue in glioma patients undergoing RT. Armodafinil did not significantl... | no |
5a9d30241d1251d03b00001b | Can gas vesicles be detected by ultrasound? | Gas vesicles-genetically encoded protein nanostructures isolated from buoyant photosynthetic microbes-have recently been identified as nanoscale reporters for ultrasound. Here, we demonstrate that genetic engineering of gas vesicles results in nanostructures with new mechanical, acoustic, surface, and functional proper... | yes |
5aa4faaed6d6b54f7900000b | Is Citrobacter rodentium pathogenic? | One day after colonization, mice were infected with the colonic pathogen, Citrobacter rodentium. The human pathogen enteropathogenic Escherichia coli (EPEC), as well as the mouse pathogen Citrobacter rodentium, colonize the gut mucosa via attaching and effacing lesion formation and cause diarrheal diseases. EPEC-like m... | yes |
5a723cd12dc08e987e00000b | Can CD55 deficiency cause thrombosis? | The loss of CD55 and CD59 renders PNH erythrocytes susceptible to intravascular haemolysis, which can lead to thrombosis and to much of the morbidity and mortality of PNH. CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis. CONCLUSIONS: CD55 deficiency with hyperactivation of complement, angiopath... | yes |
5a981dd0fcd1d6a10c00002e | Are sleep apnea and snoring associated with cardiac arrhythmias? | Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA), a common breathing disorder, is an independent risk factor for AF. There is a growing consensus in the scientific community that suggests a st... | yes |
5aa82180d6d6b54f79000015 | Are osteoclasts specialized in bone degradation? | osteoclast-mediated attack on bone Bone degradation is caused by osteoclasts, the normal bone-resorbing cells. Cathepsin K is a highly potent collagenase in osteoclasts and is responsible for bone degradation. In osteoclasts, Src controls podosome organization and bone degradation, which leads to an osteopetrotic phen... | yes |
5a733a672dc08e987e000014 | Does temsirolimus improve survival of glioblastoma patients? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
5a991ee21d1251d03b000005 | Are there sex differences in the transcriptome of the mouse hippocampus? | To better understand the possible molecular basis for the sex-biased nature of neurological disorders, we used a developmental series of female and male mice at 1, 2, and 4 months of age to assess both mRNA and protein in the hippocampus with RNA-sequencing and mass-spectrometry, respectively. The bulk of these differe... | yes |
5a96c886fcd1d6a10c00002a | A bite from the Lone Star Tick Amblyomma americanum, can cause the victim to become allergic to red meat, yes or no? | A recent discovery of an IgE antibody specific to galactose-α-1,3-galactose, which is a carbohydrate abundantly expressed on cells and tissues of beef, pork, and lamb, adds one more tool to aid the clinician in making the appropriate diagnosis. A link has been discovered between the bite of the Lone Star Tick (Amblyomm... | yes |
5a7379a83b9d13c70800000a | Is Rucaparib effective for ovarian cancer? | INTERPRETATION: In patients with BRCA mutant or BRCA wild-type and LOH high platinum-sensitive ovarian carcinomas treated with rucaparib, progression-free survival was longer than in patients with BRCA wild-type LOH low carcinomas. High LOH is associated with response to the PARP inhibitor rucaparib in BRCA wild-type o... | yes |
5a9d28981d1251d03b000017 | Does verubecestat activate BACE? | Verubecestat is a potent BACE1 enzyme inhibitor currently being investigated in Phase III trials for the treatment of mild-to-moderate and prodromal Alzheimer's disease. | no |
5a774e40faa1ab7d2e000007 | Is there a link between nuclear position and DNA repair pathway choice? | Nuclear position dictates DNA repair pathway choice. We demonstrate that DSBs induced at the nuclear membrane (but not at nuclear pores or nuclear interior) fail to rapidly activate the DNA damage response (DDR) and repair by homologous recombination (HR). Real-time and superresolution imaging reveal that DNA DSBs with... | yes |
5a992eac1d1251d03b00000c | Can non ubiquitinated Tomm20 promote mitophagy? | A total of 338 new targets were identified and from these we validated glycogen synthase kinase 3β (Gsk3β), which can phosphorylate α-synuclein, and translocase of outer mitochondrial membrane 20 (Tomm20), a mitochondrial translocase that, when ubiquitinated, promotes mitophagy, as SCFFbxo7substrates both in vitro and ... | no |
5a9931cd1d1251d03b00000d | Does SARM1 deletion cause neurodegeneration? | Finally, using neurons from two distinct mutant mouse strains whose axons are highly resistant to neurodegeneration (Wld(S) and Sarm1(-/-)), we found that the three different fibrils were secreted by axons after anterograde transport, in the absence of axonal lysis, indicating that trans-neuronal spread can occur in in... | no |
5aacd38efcf4565872000006 | Is DNA polymerase θ involved in DNA repair? | DNA polymerase θ (Pol θ) is implicated in various cellular processes including double-strand break repair and apurinic/apyrimidinic site bypass. Pol θ is the defining enzyme for a pathway of DSB repair termed "alternative end-joining" (altEJ) or "theta-mediated end-joining." DNA polymerase θ is a key player in PARP-me... | yes |
5a992d981d1251d03b00000b | Can nanoparticles be used for afterglow imaging? | Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging Afterglow or persistent luminescence eliminates the need for light excitation and thus circumvents the issue of autofluorescence, holding promise for molecular imaging. However, current persistent luminescence agents are rare... | yes |
5a8b292afcd1d6a10c00001f | Is there any role of interleukin-11 in cardiovascular fibrosis? | IL11 is a crucial determinant of cardiovascular fibrosis. Using integrated imaging-genomics analyses of primary human fibroblasts, we found that Interleukin 11 (IL11) upregulation is the dominant transcriptional response to TGFB1 exposure and required for its profibrotic effect. IL11 and its receptor (IL11RA) are expre... | yes |
5a8ee9d1fcd1d6a10c000027 | Is there a disease or condition called Exploding Head Syndrome? | This case report describes the first-ever diagnosis of exploding head syndrome in a patient with longstanding epilepsy and novel nocturnal events. Exploding head syndrome (EHS) is characterized by loud noises or a sense of explosion in the head during sleep transitions. Exploding head syndrome is characterized by the ... | yes |
58ec6eb5eda5a5767200000c | Is Enlimomab effective for stroke treatment? | However, this treatment failed to show benefit in the Enlimomab Acute Stroke Trial. There was no increase in the frequency of adverse events with increasing doses of enlimomab.CONCLUSIONS: Doses of enlimomab between 140 and 480 mg administered over 5 days did not increase the risk of adverse events in patients with isc... | no |
58ec709aeda5a5767200000e | Does International Citicoline Trial on acUte Stroke trial supports efficacy of citicoline for stroke treatment? | The meta-analysis showed that no significant differences were found in the long-term mortality (OR=0.91, 95% CI 0.07 to 1.09, P=0.30), the rate of dependency (OR=1.02, 95% CI 0.87 to 1.24, P=0.85), and the effective rate (OR=0.98, 95% CI 0.84 to 1.14, P=0.82) between citicoline group and control group. In conclusion,... | no |
5ad240f70340b9f058000015 | Is human lysyl oxidase-like 2 a glycoprotein? | This method was successfully applied to a novel recombinant protein, human lysyl oxidase-like 2. Furthermore, the glycosylation PTMs were readily detected at two glycosylation sites in the protein. application to the characterization of human lysyl oxidase-like 2 glycosylation These results suggest that the N-glycan a... | yes |
5ad3013d0340b9f058000019 | Can GDF15 be a biomarker for metformin treatment? | Growth Differentiation Factor 15 as a Novel Biomarker for Metformin. GDF15 levels are a biomarker for the use of metformin in people with dysglycemia, and its concentration reflects the dose of metformin. | yes |
5aa395fcd6d6b54f79000007 | Has rituximab been considered as a treatment for chronic fatigues syndrome? (November 2017) | The use of rintatolimod and rituximab as well as counselling, behavioural and rehabilitation therapy programs may be of benefit for CFS/ME, but the evidence of their effectiveness is still limited. | yes |
5ab9032afcf4565872000018 | Does oncogene-induced DNA replication stress inhibit genomic instability? | Oncogene-induced DNA replication stress is thought to drive genomic instability in cancer. We propose that single-stranded DNA generated in response to oncogene-induced replication stress compromises the repair of deaminated cytosines and other damaged bases, leading to the observed SNS mutator phenotype. | no |
5abd3707fcf456587200002d | Is the petrous bone used in ancient DNA sampling? | Large-scale genomic analyses of ancient human populations have become feasible partly due to refined sampling methods. The inner part of petrous bones and the cementum layer in teeth roots are currently recognized as the best substrates for such research. Ancient DNA (aDNA) research involves invasive and destructive sa... | yes |
5abc974bfcf456587200001f | Is recursive splicing more common in short introns? | Recent work in human and fruitfly tissues revealed that long introns are extensively processed cotranscriptionally and in a stepwise manner, before their two flanking exons are spliced together Cutting a Long Intron Short: Recursive Splicing and Its Implications. Furthermore, we uncover the potential to investigate th... | no |
5ac07b67dd95b2cd42000001 | Is Lysyl oxidase crosslinking collagen? | Lysyl oxidase (LOX) and LOX-like (LOXL) proteins play crucial roles in ECM remodeling due to their collagen crosslinking and intracellular functions. Lysyl oxidase-like 1, a crosslinking enzyme implicated in collagen and elastin biogenesis LOXL2 mediates collagen crosslinking The same was true for assaying lysyl oxida... | yes |
5ab2cdc5fcf4565872000016 | Is sternotomy closure done using either a sternal ZipFix™ implant or conventional steel wire following cardiac surgery? | o determine the difference in sternal infection and other infectious events between conventional wire and cable-tie-based closure techniques post-sternotomy in a collective of patients after cardiac surgery. Our study underlines a neutral effect of the sternal ZipFix™ system in patients regarding sternal infection. Pos... | yes |
5ac24f7595d0062724000003 | Is transcription of eRNA bidirectional? | In addition to widespread transcription of long non-coding RNAs (lncRNAs) in mammalian cells, bidirectional ncRNAs are transcribed on enhancers, and are thus referred to as enhancer RNAs (eRNAs). Kallikrein-related peptidase 3 (KLK3), which codes for prostate-specific antigen (PSA), is a well-known AR-regulated gene an... | yes |
5ad35933133db5eb78000001 | Is the protein pelota a ribosomal rescue factor? | a novel binding partner of the ribosome recycling protein Pelota n eukaryotes, Pelota (Dom34 in yeast) and Hbs1 are responsible for solving general problems of ribosomal stall in translation. In eukaryotes, the protein complex of Pelota (yeast Dom34) and Hbs1 translational GTPase recognizes the stalled ribosome contai... | yes |
5a9db99ffd02ddc336000001 | Is CXCL7 a chemokine? | CXCL7, a chemokine highly expressed in platelets, Chemokine CXCL7 Heterodimers | yes |
5ab144fefcf4565872000012 | The TRPM2 gene is associated with development of spontaneous thromboembolism? | TheTransientReceptorPotentialMelastatin 2 (TRPM2) is a member of G protein coupled receptor superfamily and a novel dual-function protein that possesses both ion channel andAdenosine 5'-DiphosPhataseRibose (ADPR) hydrolase function. TRPM2 is involved in Ca2+signaling in various cells as an endogenous redox sensor for o... | no |
5ac0aee419833b0d7b000004 | Is a mutation of the ZIKV's membrane protein prM responsible for the microcephaly in new-born infants? | Here we show that a single serine-to-asparagine substitution [Ser139→Asn139(S139N)] in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs) and led to more severe microcephaly in the mouse fetus, as well as higher mortality rates in neonatal mice. A singl... | yes |
5ad255210340b9f058000018 | Is lumican a secreted protein? | fibroblasts stimulated with the fibrocyte-secreted inflammatory signal tumor necrosis factor-α secrete the small leucine-rich proteoglycan lumican TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation. Secreted 70kDa lumican stimulates growth and inhibits invasion of human pancreatic cancer.... | yes |
5ac0817cd0c506ce46000001 | Is p53 a transcription factor? | As a transcription factor, p53 mainly exerts its tumor suppressive function through transcriptional regulation of many target genes. p53 functions primarily as a sequence-specific transcription factor that controls the expression of hundreds of protein-coding genes and noncoding RNAs, including microRNAs (miRNAs) and l... | yes |
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