id stringlengths 24 24 | question stringlengths 21 168 | context stringlengths 79 19.2k | answer stringclasses 2
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56c863385795f9a73e000015 | Is macitentan an ET agonist? | Administration of an ET receptor antagonist, either bosentan or macitentan, markedly attenuated PD-induced MMT, fibrosis, angiogenesis, and peritoneal functional decline. Macitentan is an oral, once-daily, dual endothelin (ET)A and ETB receptor antagonist with high affinity and sustained receptor binding that was appr... | no |
530b4f49970c65fa6b00000a | Can we use platelet biomarkers to study Alzheimer's disease? | Platelet biomarkers in Alzheimer's disease. platelets are the most important source of circulating forms of the amyloid precursor protein and other important proteins such as Tau and glycogen synthase kinase-3B. Alternative plasma and platelet measures are described, The success of these studies led to the application ... | yes |
53175e25b166e2b806000007 | Is CHEK2 involved in cell cycle control? | Moreover, cell-cycle progression genes [i.e. E2F transcription factor (E2F) family and histone deacetylase ( HDAC )] and DNA-repair genes [i.e. growth arrest and DNA-damage-inducible, gamma ( GADD45G ) family and serine/threonine-protein kinase Chk2 ( CHEK2)] were also increased. As CHEK2 is a cell-cycle master control... | yes |
530c7fa4970c65fa6b000012 | Are the proteins Erbin (LAP2) and Merlin cooperating? | Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta. The results show that the epithelial-enriched protein Erbin controls the function of the NF2 tumor suppressor Merlin by determining the output of Merlin's physical interactions with active PAK2. Erbin co... | yes |
56e5aeec0c19e5451d000002 | Are adenylyl cyclases always transmembrane proteins? | ransmembrane adenylyl cyclase Transmembrane adenylyl cyclase (tmAC) and soluble AC (sAC) Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl cyclases (tmACs... | no |
56c1d846ef6e39474100002e | Does neuroglobin has neuroprotective properties in the setting of traumatic brain injury? | Neuroglobin has shown rich neuroprotective effects against cerebral hypoxia, and therefore has the potential to impact outcomes after traumatic brain injury (TBI). Neuroglobin (Ngb) is proposed to be a neuron-specific, hypoxia-responsive, neuroprotective protein. CONCLUSION: The increased expression of neuroglobin in... | yes |
533eb89fc45e133714000012 | Does the concentration of protein HIF-1α increase after the administration of the cytoprotective prodrug"amifostine" (ethyol) ? | We demonstrated that the treatment of several human cancer cell lines with therapeutical doses of WR-1065 led to a strong induction of different VEGF-A mRNA isoforms independently of HIF-1alpha e investigated the involvement of hypoxia-regulated proteins (Hypoxia inducible factors HIF1alpha, HIF2alpha and carbonic anhy... | yes |
5139ec51bee46bd34c000006 | Do Conserved noncoding elements act as enhancers? | The aCNEs are rich in tissue-specific enhancers Transgenic zebrafish assay of some human CNE enhancers that have been lost in teleosts Conserved noncoding elements (CNEs) in vertebrate genomes often act as developmental enhancers, In all four cases where the zebra fish and human CNE display a similar expression pattern... | yes |
54edef0594afd6150400000d | Can the iPS cell technology be used in Fanconi anemia therapy? | We explain a protocol for the reproducible generation of genetically corrected iPSCs starting from the skin biopsies of Fanconi anemia patients using retroviral transduction with OCT4, SOX2 and KLF4 Before reprogramming, the fibroblasts and/or keratinocytes of the patients are genetically corrected with lentiviruses ex... | yes |
52b2ed144003448f55000004 | Can Preimplantation Genetic Diagnosis (PGD) be used for gender selection? | This testing is used for identifying singlegene disorders, chromosomal abnormalities, mitochondrial disorders, gender selection in non-mendelian disorders with unequal gender distribution, aneuploidy screening, and other preconceptually identified genetic abnormalities in prospective parents. Although many clinics of... | yes |
52b06a68f828ad283c000005 | Is Tuberous Sclerosis a genetic disease? | Tuberous sclerosis complex (TSC) is a genetic disease Tuberous sclerosis is a rare genetic disease Tuberous sclerosis complex (TSC) is a multisystem genetic disease Tuberous sclerosis complex (TSC) is a genetic disease The disease is caused by mutational inactivation of the tumor suppressor gene tuberous sclerosis comp... | yes |
56c1f03cef6e394741000054 | Does TRIM37 gene mutation causes Mulibrey nanism? | OBJECTIVE: We studied pubertal development and fecundity in males with Mulibrey nanism (MUL) caused by mutations in the TRIM37 gene. In MUL, mutations in TRIM37 lead to disturbance of sexual maturation, and fertility is severely compromised. It is caused by recessive mutations in the TRIM37 gene encoding for the perox... | yes |
534bf050aeec6fbd07000015 | Have thyronamines effects on fat tissue? | Intraperitoneal or central injection of 3-T(1)AM or T(0)AM into mice, rats, or Djungarian hamsters caused various prompt effects, such as metabolic depression, hypothermia, negative chronotropy, negative inotropy, hyperglycemia, reduction of the respiratory quotient, ketonuria, and reduction of fat mass. | yes |
530c7cfd970c65fa6b00000c | Is there any protein that undergoes both mono-ubiquitination and poly-ubiquitination? | The yeast G protein alpha subunit Gpa1 represents a rare example of a protein that undergoes both mono- and poly-ubiquitination. Expression of p34 promotes PTEN poly-ubiquitination, leading to PTEN protein degradation, whereas p34 knockdown results in PTEN mono-ubiquitination. These fingers possess E3 activities of mo... | yes |
56c1f01eef6e394741000046 | Is olaparib effective for prostate cancer? | We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibition with olaparib.METHODS: We conducted a phase 2 trial in which patients with metastatic, castration-resistant prostate cancer were treated w... | yes |
5151b8efd24251bc0500007a | Is physical performance influenced by thyroid hormone metabolism? | Longitudinal analysis showed that in Eut men higher baseline FT4 was significantly (p = 0.02) predictive of a lower SPPB score at the 3-year follow-up Even a modest thyroid hormone excess is associated with a reduced physical function in elderly men. Oral L-thyroxine treatment was started and at a 1-month follow-up exa... | yes |
553d0005f321868558000011 | Do plant genomes contain CpG islands? | This study represents the first systematic genome-scale analysis of DNA curvature, CpG islands and tandem repeats at the DNA sequence level in plant genomes, and finds that not all of the chromosomes in plants follow the same rules common to other eukaryote organisms, suggesting that some of these genomic properties mi... | yes |
530cf4c54a5037880c000002 | Are high-flow nasal cannulae effective for treatment of preterm infants? | The use of high-flow nasal cannulae is an increasingly popular alternative to nasal continuous positive airway pressure (CPAP) for noninvasive respiratory support of very preterm infants (gestational age, <32 weeks) after extubation. The use of high-flow nasal cannulae was noninferior to the use of nasal CPAP, with tre... | yes |
51682382298dcd4e51000066 | Does triiodothyronine play a regulatory role in insulin secretion from pancreas? | Our findings establish that p43 is an important regulator of glucose homeostasis and pancreatic β-cell function and provide evidence for the first time of a physiological role for a mitochondrial endocrine receptor. The p43(-/-) mice had a major defect in insulin secretion both in vivo and in isolated pancreatic islets... | yes |
54f482d264850a5854000009 | Is the Histidine-Rich Calcium Binding protein (HRC) related to arrhythmias and cardiac disease? | A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine-rich Ca(2+)-binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy. These findings suggest that aberrant SR Ca2+ release and increased susceptibility to delayed afterdepolarizations under... | yes |
531481ade3eabad021000016 | Can adult humans be induced to produce fetal hemoglobin? | At the time of birth, HbF accounts for approximately 70% of the total Hb. whereas in the trace amounts of HbF that is found in the adult it reverses to 40:60 because of a gamma- to beta-globin gene switch With the increased understanding and discovery of molecular regulators of haemoglobin switching, such as BCL11A, ... | yes |
533581f5d6d3ac6a3400004d | Is Turcot syndrome associated with glioblastoma? | Turcot syndrome is an autosomal recessive disorder clinically characterized by the occurrence of primary tumors of the central nervous system and adenomatous colonic polyps during the first or second decades of life, with a spectrum of clinical features such as "café-au-lait" spots, axillary freckling, and hyperpigment... | yes |
53314c98d6d3ac6a3400003b | Does SCRIB deregulation promote cancer? | human homologs of Drosophila dlg, scrib, and lgl are cancer-associated genes. Aberrant overexpression of the cell polarity module scribble in human cancer. we show that Scrib is nearly universally overexpressed in cultured tumor cell lines and genetically disparate cancer patient series compared with matched normal tis... | yes |
531d3dc0267d7dd053000005 | Is cardiac magnetic resonance imaging indicated in the pre-participation screening of athletes? | As modern imaging further enhances our understanding of the spectrum of athlete's heart, its role may expand from the assessment of athletes with suspected disease to being part of comprehensive pre-participation screening in apparently healthy athletes. Finally we will address the role of CMR in pre-participation scre... | no |
51542e84d24251bc05000083 | Is imatinib an antidepressant drug? | Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Surgery remains the elective treatment. We retrospectively compared two group of patients, who underwent surgery for GIST before and after Imatinib advent in order to analyze the recurrence and survival rate. Adjuv... | no |
55413142182542114d000002 | Are ultraconserved elements depleted among copy number variants (CNVs)? | We have demonstrated that nonexonic UCEs are depleted among segmental duplications (SDs) and copy number variants (CNVs) and proposed that their ultraconservation may reflect a mechanism of copy counting via comparison. Here, we report that nonexonic UCEs are also depleted among 10 of 11 recent genomewide data sets of ... | yes |
5156be5ed24251bc05000087 | Is the microRNA 132 (miR-132) involved in brain pathologies? | miR-132 dysregulation and subsequent abnormal expression of miR-132 target genes contribute to the neurodevelopmental and neuromorphological pathologies present in schizophrenia. micro-RNAs encoding miR-9, miR-124a, miR-125b, miR-128, miR-132 and miR-219 are abundantly represented in fetal hippocampus, are differential... | yes |
5522fadb7b523f2123000001 | Are Notch mutations related to T-cell Acute Lymphoblastic Leukemia (T-ALL)? | Notch receptors participate in a highly conserved signalling pathway that regulates normal development and tissue homeostasis in a context- and dose-dependent manner. Deregulated Notch signalling has been implicated in many diseases, but the clearest example of a pathogenic role is found in T-cell lymphoblastic leukaem... | yes |
54f4c382d0d681a040000006 | Is the protein FAK (Focal Adhesion Kinase) phosphorylated? | Overexpression of NEDD9 led to tyrosine phosphorylation of FAK and SRC oncoproteins, yrosine phosphorylated FAK TNFα contributes for attenuating both Y397FAK and Y416Src phosphorylations in osteoblasts. It was possible to show that TNFα provokes attenuation at Y-phosphorylation of both FAK (at Y397 ) ownregulation of... | yes |
551c2c276b348bb82c00000c | Does ghrelin play a role in ischemic stroke? | Recent evidence suggests that ghrelin may also be neuroprotective after injury in animal models of cerebral ischemia. Overall, these experiments point to a neurodegenerative but antiapoptotic effect of endogenous ghrelin in this model of global ischemia, highlighting that further research is essential before we can app... | yes |
56e6f419a12c1fc13b000002 | Is LPS a microbial product? | and microbial translocation [lipopolysaccaride (LPS), microbial 16S rDNA and sCD14] Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections bacterial lipopolysaccharide (LPS) sterile bacterial wall lipopolysaccharide (LPS) to investigate the changes in innate ... | yes |
51be1750047fa84d1d000005 | Has field-programmable gate array (FPGA) technology been used to solve sequence alignment problems? | A linear error model for the raw intensity data and Burrows-Wheeler transform (BWT) based alignment are combined utilizing a Bayesian score function, which is then globally optimized over all possible genomic locations using an efficient branch-and-bound approach. The algorithm has been implemented in soft- and hardwar... | yes |
52b2efcb4003448f55000005 | Is Achondroplasia associated with hearing loss? | A hearing screening program was performed to determine the prevalence of hearing loss and abnormal tympanometry in individuals with short-stature skeletal dysplasias attending a national meeting. Behavioral audiometry, otoacoustic emission testing, and tympanometry were used to assess hearing. Failed hearing screen was... | yes |
53455e0caeec6fbd0700000f | Is the JNK pathway activated during liver regeneration? | analysis of the role of JNK signaling pathway in regulating cell proliferation and apoptosis of rat liver regeneration paths of JNK signaling pathway regulate cell proliferation and apoptosis in both LR c-jun is not mandatory for mouse hepatocyte proliferation Mice lacking c-jun in the liver display impaired regenerat... | yes |
56caf71b5795f9a73e00002d | Is STAT3 transcription factor regulated by mTORC1? | Mechanistically, mTORC1 mediated IL-6-induced Stat3 activation in intestinal epithelial cells to stimulate the expression of downstream targets essential for cell proliferation and tissue regeneration. Therefore, mTORC1 signaling critically protects against inflammatory bowel disease through modulation of inflammation-... | yes |
517139098ed59a060a000004 | Is calcium overload involved in the development of diabetic cardiomyopathy? | High-glucose treatment resulted in increased intracellular calcium ([Ca2+]i) which was mobilized to the mitochondria. Concomitant intra-mitochondrial calcium ([Ca2+]m) increase resulted in enhanced reactive oxygen and nitrogen species generation. These events led to mitochondrial dysfunction and apoptosis. The novel fi... | yes |
532bfd15d6d3ac6a34000017 | Is RIP1 (RIP-1) part of the necrosome? | formation of a different necrosome whose components, besides RIP1 and RIP3, are still unknown necrosome complex consisting of RIP1, RIP3, FADD, caspase-8 and cFLIP(L). assembly of a supramolecular complex containing the receptor-interacting protein kinases 1 and 3 (RIP1 and RIP3) that delivers a pronecrotic signal. Suc... | yes |
56c30ce99d3e5f1412000002 | Is the protein KCNQ2 associated with idiopathic epilepsy? | Juvenile idiopathic epilepsy (JIE) in Arabian foals resembles benign-familial neonatal convulsion (BFNC) syndrome, a rare idiopathic epilepsy of new-born humans. BFNC syndrome exhibits genetic heterogeneity, as has been hypothesised to occur in Arabian foals, and is known to be caused by mutations in the voltage-gated ... | yes |
571696d9cb4ef8864c000009 | Can RNAPolII function as an RNA-dependent RNA-polymerase? | RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA RNA polymerase II (Pol II) is a well-characterized DNA-dependent RNA polymerase, which has also been reported to have RNA-dependent RNA polymerase (RdRP) activity. . Our studies provide compelling evidence that mammalia... | yes |
514a0f0ad24251bc05000052 | Does the Oncotype DX test work with paraffin embedded tissues? | The Oncotype-DX Breast Cancer Assay (Genomic Health, Redwood City, CA) quantifies gene expression for 21 genes in breast cancer tissue by performing reverse transcription polymerase chain reaction (RT-PCR) on formalin-fixed paraffin-embedded (FFPE) tumour blocks that are obtained during initial surgery (lumpectomy, mas... | yes |
52e7870a98d023950500001a | Is the PTPN22 gene a biomarker for Rheumatoid Arthritis? | Combined longitudinal analysis of the 2 cohorts suggests further association of several loci with Larsen score (KIF5A, PTPN22, AFF3, TAGAP) and therefore a significant accumulation of RA severity markers among RA susceptibility markers (p = 0.016) A non-intronic marker at TNFAIP3, GIN1/C5orf30, STAT4, ANKRD55/IL6ST, BL... | yes |
5149e23dd24251bc0500004b | Is marijuana use associated with increased risk for stroke? | The illicit drugs more commonly associated with stroke are psychomotor stimulants, such as amphetamine and cocaine. Less commonly implicated are opioids and psychotomimetic drugs, including cannabis. Among 326 patients (184 males), the most frequent stroke risk factors overall were dyslipidaemia (187), smoking (161), h... | yes |
5715c16dcb4ef8864c000004 | Does fibronectin constitute a serum biomarker for Duchenne muscular dystrophy? | Fibronectin is a serum biomarker for Duchenne muscular dystrophy There was a significant increase in fibronectin levels in DMD patients compared to age-matched controls. Fibronectin levels in patients with Becker muscular dystrophy, Bethlem myopathy, or myasthenia gravis were comparable to control levels. Progressive e... | yes |
550748a3bde8548216000001 | Are mutations in the STXBP1 gene associated with epilepsy? | Folinic acid responsive epilepsy in Ohtahara syndrome caused by STXBP1 mutation. A novel mutation in STXBP1 gene in a child with epileptic encephalopathy and an atypical electroclinical pattern. Mutations in STXBP1 gene, encoding the syntaxin binding protein 1, have been recently described in Ohtahara syndrome, or earl... | yes |
5318352fb166e2b806000011 | Is mitofusin 2 a receptor for parkin? | Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin translocation to damaged mitochondria. We show that the mitochondrial outer membrane guanosine triphosphatase mitofusin (Mfn) 2 mediates Parkin recruitment to damaged mitochondria. Mfn2 f... | yes |
531d1279b166e2b806000042 | Is there a relationship between thyroid hormone altered metabolism and coronary artery disease? | The results showed that higher levels of TSH within the reference range were independently associated with the presence of CAD only among subjects less than or equal to 65 years old, suggesting age might influence the relationship. FT3 levels within the normal range were inversely correlated with the presence and sever... | yes |
58aa0a62396a458e50000007 | Are microtubules marked by glutamylation? | Together with detyrosination, glutamylation and other modifications, tubulin acetylation may form a unique 'language' to regulate microtubule structure and function. Glutamylation, the most prevalent tubulin posttranslational modification, marks stable microtubules and regulates recruitment and activity of microtubule-... | yes |
58a8962338c171fb5b000007 | Is synapsin a phosphoprotein? | Synapsin is an evolutionarily conserved presynaptic phosphoprotein. Synapsins as a family of presynaptic terminal phosphoprotein participates in neuronal development Synapsin III (SynIII) is a phosphoprotein The neuronal phosphoprotein synapsin III Synapsin II is a member of the neuronal phosphoprotein family. phosphop... | yes |
58a0d87a78275d0c4a000053 | Is Thalidomide currently a marketed drug? | In this retrospective study, pharmacy claims were analyzed for those patients with a diagnosis of MM who received thalidomide, The Japanese POEMS syndrome with Thalidomide (J-POST) Trial is a phase II/III multicentre, double-blinded, randomised, controlled trial that aims to evaluate the efficacy and safety of a 24-wee... | yes |
58a6bce660087bc10a000029 | Could BRCA gene test used for breast and ovarian cancer risk? | Participation of Korean families at high risk for hereditary breast and ovarian cancer in BRCA1/2 genetic testing. The prevalence of BRCA1/2 mutations in Korean ovarian cancer patients irrespective of the family history was significantly higher than previously reported. Possible founder mutations in Korean ovarian canc... | yes |
58a2da4260087bc10a000005 | Has Glucose-6-phosphate dehydrogenase (G6PD) deficiency an X-linked inheritance? | Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest red cell enzymopathy in humans and has an X-linked inheritance. This genetic defect shows sex linked inheritance and a marked heterogeneity. G6PD deficiency is the most common enzymopathy in the world. Study of the deficiency pattern amongst family ... | yes |
58a341a660087bc10a000017 | Is the toxin produced by Clostridium botulinum always deadly? | Animals treated with trace elements recovered. It appears that intestinal microbiota dysbiosis and trace element deficiency could explain the extensive emergence of chronic Botulism. The patient was treated with human botulism immune globulin and had rapid recovery in weakness. A stool sample from the patient was posit... | no |
588fa4b9ed9bbee70d000006 | Is ocrelizumab effective for treatment of multiple sclerosis? | Advances made in immunomodulation are driving the progress being made in the treatment of MS. Ocrelizumab is the first treatment with positive results in the primarily progressive forms and tocilizumab, a drug product for rheumatoid arthritis, stands out as a potential candidate for the treatment of neuromyelitis optic... | yes |
58848a13e56acf517600000d | Is there a role of regorafenib for sarcoma treatment? | Regorafenib has been approved for third-line therapy. Study protocol of REGOSARC trial: activity and safety of regorafenib in advanced soft tissue sarcoma: a multinational, randomized, placebo-controlled, phase II trial. DISCUSSION: The design of this trial allows an assessment of regorafenib activity over placebo in f... | yes |
587f5d6492a5b8ad44000003 | Is exon skipping correlated with exon circularization? | Exon Skipping Is Correlated with Exon Circularization We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome Exon Skipping Is Correlated with Exon Circularization. We find that circularization of exo... | yes |
58a5b01760087bc10a000023 | Is NADPH oxidase 5 expressed in rodents? | Because the Nox5 gene is absent in rodents, we generated transgenic mice expressing human Nox5 in a podocyte-specific manner (Nox5(pod+)). The NADPH oxidase 5 (NOX5) gene is present in humans but not rodents. The data document that the NOX5 gene was expressed in cells of lagomorphs unlike rodents, making the rabbit a... | no |
58a957a8cc344ae31e000001 | Does Vitamin D induce autophagy? | 1,25(OH)2D treatment was accompanied by autophagy activation Autophagy signaling pathway was regulated by vitamin D3 vitamin D induces autophagy Vitamin D shows promise for the prevention and amelioration of pathologic responses in IBD, an effect that is mediated, at least in part, by the induction and modulation of a... | yes |
5896399978275d0c4a00000b | Is RASA2 involved in melanoma? | Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated wit... | yes |
58a6b98860087bc10a000028 | Is SUMOylation a post-translational modification in eukaryotes? | SUMOylation, the conjugation of target proteins with SUMO (small ubiquitin-related modifier), is a type of post-translational modification in eukaryotes and involves the sequential action of activation (E1), conjugation (E2) and ligation (E3) enzymes. Plants have evolved to cope with changing environmental conditions.... | yes |
58a93877ee23e0236b000001 | Is the protein lefty an inhibitor of nodal? | The expression of lefty, an inhibitor of nodal is often reduced in tumor cells. Nodal, and an inhibitor, Lefty. as well as the expression of Lefty, an inhibitor of nodal signaling, he Nodal inhibitor lefty The morphogen Nodal was proposed to form a long-range signaling gradient via a reaction-diffusion system, on the ... | yes |
5884793ce56acf5176000008 | Is Migalastat used for treatment of Fabry Disease? | Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study. BACKGROUND: Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, resulting in α-galactosidase (α-Gal) deficiency and accumulation... | yes |
58a341eb60087bc10a000018 | Do statins cause diabetes? | Statin use has been associated with increased risk of developing type 2 diabetes (T2DM), and with impaired glycemic control in T2DM patients The relationship between T2DM and statins is further complicated since these drugs can cause new onset diabetes (NOD) although there is an overall benefit in terms of preventing v... | yes |
587f56c392a5b8ad44000001 | Are deletions of chromosomal regulatory boundaries associated with congenital disease? | Deletions of chromosomal regulatory boundaries are associated with congenital disease. Our results suggest that enhancer adoption caused by deletions of regulatory boundaries may contribute to a substantial minority of copy-number variation phenotypes and should thus be taken into account in their medical interpretatio... | yes |
587dfde9ae05ffb474000001 | Can the Micro-C XL method achieve mononucleosome resolution? | We present Micro-C XL, an improved method for analysis of chromosome folding at mononucleosome resolution We present Micro-C XL, an improved method for analysis of chromosome folding at mononucleosome resolution. Micro-C XL: assaying chromosome conformation from the nucleosome to the entire genome. Micro-C XL provides ... | yes |
58a0a28a78275d0c4a000051 | Can Diabetes be caused by a defect in a potassium chanel? | Mutations in KATP channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mellitus and congenital hyperinsulinism, respectively. To date, all patients affected by neonatal diabetes due to a mutation in the pore-forming subunit of the channel (Kir6.2, KCNJ11) are heterozygous for the muta... | yes |
588485bbe56acf517600000b | Is rucaparib used for ovarian cancer treatment? | While olaparib is the first PARP inhibitor to receive approval for ovarian cancer treatment, others including rucaparib and niraparib are clearly effective in this disease and, within the next year or two, the results of ongoing randomised trials will clarify their respective roles. Similar trials with other PARP inhi... | yes |
58b9585c22d3005309000010 | Could hypophosphatemic rickets cause craniosynostosis? | This study examines a series of patients with hypophosphatemic rickets and craniosynostosis to characterize the clinical course and associated craniofacial anomalies. Hypophosphatemic rickets and craniosynostosis: a multicenter case series. A 20-year retrospective review identified patients with hypophosphatemic ricke... | yes |
589a246878275d0c4a000030 | Is vortioxetine effective for treatment of depression? | Vortioxetine is the most recently approved medication for the treatment of major depressive disorder (MDD). [Vortioxetine: a new antidepressant to treat depressive episodes]. Vortioxetine is a new antidepressant, which mechanism of action is multimodal, targeting the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT3, 5-HT7 receptors and ... | yes |
58bca1c202b8c6095300000b | Can beans induce apoptosis? | A 60-kDa glucosamine binding lectin, white kidney bean lectin (WKBL), was purified from Phaseolus vulgaris cv. white kidney beans, by application of anion exchange chromatography on Q-Sepharose, affinity chromatography on Affi-gel blue gel, and FPLC-size exclusion on Superdex 75. The anti-proliferative activity of WKBL... | yes |
58a337af60087bc10a000016 | Is treatment resistant depression related to vitamin B9? | Suboptimal serum and red blood cell folate levels have been associated with a poorer response to antidepressant therapy, a greater severity of symptoms, later onset of clinical improvement, and overall treatment resistance. This article reviews the evidence for L-methylfolate and folic acid as antidepressive agents in ... | yes |
58847e36e56acf5176000009 | Is adalimumab effective for hidradenitis suppurativa? | If patient is not improved, then Adalimumab 160 mg at week 0, 80 mg at week 2; then 40 mg subcutaneously weekly should be administered (LOE Ib, SOR A). If improvement occurs then therapy should be maintained as long as HS lesions are present. Reduction in pain scores and improvement in depressive symptoms in patients w... | yes |
5886222a3b87a8a738000005 | Can NEECHAM Confusion Scale be used for evaluation of postoperative delirium? | Sampling was achieved in a nonrandomized targeted manner and delirium was assessed using NeeCham questionnaire. Delirium in older patients: a diagnostic study of NEECHAM Confusion Scale in surgical intensive care unit. AIMS AND OBJECTIVES: To estimate the diagnostic value and determine the feasibility of the NEECHAM C... | yes |
58a1da4e78275d0c4a000059 | Has small pox been eradicated from the world? | small pox has been eradicated. smallpox is now eradicated In May 1980 the World Health Assembly in Geneva announced in solemn form the world-wide eradication of the small-pox and gave recommendations to the member countries for concluding measures concerning the small-pox vaccination, the foundation of vaccine reserves... | yes |
58963b0278275d0c4a00000c | Is there alternative polyadenylation during zebrafish development? | Extensive alternative polyadenylation during zebrafish development. At 2 h post-fertilization, thousands of unique poly(A) sites appear at locations lacking a typical polyadenylation signal, which suggests a wave of widespread cytoplasmic polyadenylation of mRNA degradation intermediates. Our insights into the identiti... | yes |
587e276be96a600607000001 | Are alterations in ultraconserved elements implicated in breast cancer? | SNPs in ultraconserved elements and familial breast cancer risk In the present study, we investigated the influence of six SNPs within UCEs on familial breast cancer risk. Two out of six SNPs showed an association with familial breast cancer risk This is the first study indicating that SNPs in UCEs might be associated... | yes |
588f5e9994c1512c50000004 | Is there any tool that facilitates the functional analysis of cis-regulatory regions in zebrafish? | Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish. he cis-regulatory sequences control when, where, and how much genes are transcribed and can activate (enhancers) or repress (silencers) gene expression. Here, we describe ... | yes |
589644c478275d0c4a00000d | Have the promoter regions of the genes implicated in Rett Syndrome been characterized with CAGE? | CAGE-defined promoter regions of the genes implicated in Rett Syndrome. Mutations in three functionally diverse genes cause Rett Syndrome. Although the functions of Forkhead box G1 (FOXG1), Methyl CpG binding protein 2 (MECP2) and Cyclin-dependent kinase-like 5 (CDKL5) have been studied individually, not much is known ... | yes |
58bbb68b22d3005309000015 | Has "RNA interference" been awarded Nobel prize? | Since the first unequivocal description of RNA interference (RNAi) in 1998, it has remained one of the hottest topics under investigation, culminating in the award of a Nobel Prize to its discoverers in 2006. RNA interference (RNAi) is considered one of the most powerful genomic tools which allows the study of drug dis... | yes |
5889e2c83b87a8a73800000a | Is there any role for Pds5b in cohesion establishment? | Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. Here, we demonstrate that Pds5 proteins are essential for cohesion establishment by allowing Smc3 acetylation by the cohesin acetyl transferases (CoATs) Esco1/2 and binding of Sororin. While both proteins contribute to telomere and a... | yes |
58a6d89660087bc10a00002b | Could plasmepsins be used as targets for developing anti-malaria drugs? | Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors. Given that the parasite needs the resulting amino acid building blocks for its growth and development, plasmepsins are an important antimalarial drug target. Due to early crystallographic evidence, plasmepsin II (Plm II) emerged a... | yes |
5895d0457d9090f35300000d | Is avanafil indicated for treatment of erectile dysfunction? | CONTEXT: Avanafil (AVA) is used in the treatment of erectile dysfunction, but is reported for its poor aqueous solubility. BACKGROUND: Phosphodiesterase 5 inhibitors (PDE5-Is) sildenafil, vardenafil, tadalafil and the recently approved avanafil represent the first-line choice for both on-demand and chronic treatment o... | yes |
5898500478275d0c4a000017 | Is there a role for gamma knife in treatment of Obsessive-Compulsive Disorder? | OBJECTIVE Functional Gamma Knife radiosurgery (GKRS) procedures have been increasingly used for treating patients with tremor, trigeminal neuralgia (TN), and refractory obsessive-compulsive disorder. METHODS The authors constructed a linear-quadratic model of BED in functional GKRS with a dose-protraction factor to cor... | yes |
58a5924060087bc10a000020 | Can NADPH oxidase be inhibited by apocynin and diphenylene iodonium? | Ang II treatment also led to a significant increment in intracellular reactive oxygen species generation, which could be fully abolished by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors apocynin or diphenylene iodonium, indicating that Ang II enhanced oxidative stress via a NADPH oxidase-depend... | yes |
58a5add260087bc10a000022 | Does NADPH oxidase 5 require any subunit for function? | Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain. While Nox1-4 require regulatory subunits, including p22phox, Nox5 activity does not depend on any subunits. Thus, Nox5 forms a catalytically active oligomer in the membrane that is mediated by its dehydrogenase domain. Coexpr... | no |
589c334e78275d0c4a00003d | Is NSD-1015 an inhibitor of Aromatic L-Amino Acid Decarboxylase? | When pretreated with a central AADC inhibitor (NSD-1015), further application of l-dopa failed to increase the motoneuron activity although the expression of DA in the AADC cells was not completely inhibited. Inhibition of Ddc by AADC inhibitor NSD-1015 or anti-sense morpholino oligonucleotides (MO) reduced brain volu... | yes |
58bbb77e22d3005309000017 | Is pseudouridine a RNA modification? | Pseudouridine (Ψ) is the most abundant of>150 nucleoside modifications in RNA. The number and position of the pseudouridines of Haloarcula marismortui and Deinococcus radiodurans large subunit RNA have been determined by a combination of total nucleoside analysis by HPLC-mass spectrometry and pseudouridine sequencing ... | yes |
58cd675c02b8c6095300003b | Can telomere length shortening be reversed by telomerase? | Telomere length is regulated around an equilibrium set point. Telomeres shorten during replication and are lengthened by telomerase. Disruption of the length equilibrium leads to disease; thus, it is important to understand the mechanisms that regulate length at the molecular level. High telomerase activity is detecte... | yes |
58ce5a1602b8c60953000049 | Is ABCE1 involved in ribosomal recycling? | Ribosome recycling orchestrated by the ATP binding cassette (ABC) protein ABCE1 can be considered as the final-or the first-step within the cyclic process of protein synthesis, connecting translation termination and mRNA surveillance with re-initiation. Recent studies have identified ABCE1 as a ribosome-recycling fact... | yes |
58cbb55402b8c60953000033 | Does oculocutaneous albinism show an autosomal recessive inheritance? | Oculocutaneous albinism (OCA) is an autosomal recessive disorder characterized by hypopigmentation in eyes, hair and skin, accompanied with vision loss. Oculocutaneous albinism (OCA) is an autosomal recessive hereditary pigmentation disorder affecting humans and several other animal species. Oculocutaneous albinism t... | yes |
58a71bb960087bc10a00002d | Are Ultra-conserved elements (UCEs) enriched in segmental duplications? | Here we address the process by which CNVs become depleted of UCEs. We begin by showing that depletion for UCEs characterizes the most recent large-scale human CNV datasets and then find that even newly formed de novo CNVs, which have passed through meiosis at most once, are significantly depleted for UCEs. In striking ... | no |
58cd6d9702b8c6095300003c | Do normal cells express the protein TERT? | Since telomerase has been recognized as a relevant factor distinguishing cancer cells from normal cells, it has become a very promising target for anti-cancer therapy Telomerase plays a pivotal role in cellular immortality and tumorigenesis. Its activity is normally not detectable in most somatic cells while it is reac... | no |
588fbedced9bbee70d000007 | Is there any involvement of the long non-coding RNA Gomafu in schizophrenia? | The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Here, we profile these transcriptomic responses and show that long non-coding RNAs (lncRNAs) are dynamically regulated by neuronal activation, including acute downregulat... | yes |
58bfeb2b02b8c6095300001a | Is butterfly rash a symptom of Systemic lupus erythematosus? | Diagnosing SLE can be challenging because of the myriad of clinical features and substantial variability between patients. Cutaneous involvement is present in about 60% of cases and typically manifests as a malar or butterfly rash. The prevalence of systemic lupus erythematosus (SLE) is 28 per 100,000. We report a 12 ... | yes |
58b6d26122d300530900000e | Is infertility characteristic of individuals with Fanconi anemia? | PALB2 links BRCA1 and BRCA2 in homologous recombinational repair of DNA double strand breaks (DSBs). Mono-allelic mutations in PALB2 increase the risk of breast, pancreatic, and other cancers, and biallelic mutations cause Fanconi anemia (FA). Moreover, mutant males showed reduced fertility due to impaired meiosis and... | yes |
5896e4d478275d0c4a000015 | Is golimumab effective for ulcerative colitis? | Initial experience with golimumab in clinical practice for ulcerative colitis. BACKGROUND: Golimumab is a TNF-blocking agent indicated as a second-line therapy in ulcerative colitis. CONCLUSIONS: In this short study, golimumab seems to be an alternative treatment in naive and non-naive anti-TNF ulcerative colitis patie... | yes |
58967c9978275d0c4a000011 | Does mTOR regulate the translation of MAPKAPK2? | mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pr... | yes |
58bd672d02b8c60953000011 | Could divalent metal transporter 1 deficiency lead to anemia? | The divalent metal transporter 1 (DMT1) is a major iron transporter required for iron absorption and erythropoiesis. Loss of DMT1 function results in microcytic anemia. Dysfunction of human DMT1 is associated with several pathologies such as iron deficiency anemia hemochromatosis, Parkinson's disease and Alzheimer's d... | yes |
58bdc76102b8c60953000013 | Does the hERG gene code for a protein which is part of a sodium channel? | The human ether-à-go-go-related gene (hERG 1a) potassium channel is critical for cardiac repolarization Human ether-a-go-go-related gene (hERG) channels conduct delayed rectifier K(+) current. The KvLQT1 and minK genes code the slowly activating, delayed rectifier (Iks) potassium channel, the HERG gene code the rapidl... | no |
589a245778275d0c4a000024 | Is lenvatinib effective for renal cell carcinoma? | However, the combination of lenvatinib, a multitargeted agent that inhibits VEGF as well as FGF receptors, and everolimus demonstrated promising results in a randomized phase II trial. The FDA has approved the combination of lenvatinib and everolimus to treat advanced or metastatic renal cell carcinoma. Moreover, a re... | yes |
58ce69cd1f5fb2b734000003 | Does HuR bind to the untranslated regions (UTRs) of mRNAs? | HuR is also overexpressed during tumourigenesis and is abnormally present within the cytoplasm, where it binds to AU-rich elements in the 3'UTRs of target mRNA and post-transcriptionally regulates the expression of its target genes. Human antigen R (HuR) is a ubiquitous 32 kDa protein comprising three RNA Recognition M... | yes |
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