sentences stringlengths 1 6.19k | matches dict | sem_embed listlengths 768 768 | rhet_embedding listlengths 768 768 | aid stringlengths 7 11 | Category stringclasses 13
values |
|---|---|---|---|---|---|
Evaluated were 860 patients with ACS from January through December, 2003. | {
"m": "Referring back to the research aims or procedures",
"s": "548.01"
} | [
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-0.3530535101890564,... | W1973979946 | Aims |
We evaluated baseline characteristics, ACS mode of presentation, medication during hospital stay, indication for clinical treatment or myocardial revascularization MR and inhospital mortality. | {
"m": "Indicating the methodology for the current research",
"s": "305.0"
} | [
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-1.11... | W1973979946 | Method |
Five hundred and three 58.3 were male, mean age 62.6 years 11.9. | {
"m": "Describing the characteristics of the participants",
"s": "360.68"
} | [
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0.01321119628846645... | [
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-0.1535242646932602,... | W1973979946 | Method |
Seventyeight 9.1 were discharged with the diagnosis of acute STelevation myocardial infarction STEMI, 238 27.7 with nonSTelevation myocardial infarction nonSTEMI, 516 60 with unstable angina UA, two 0.2 with atypical manifestations of ACS and 26 3 with noncardiac chest pain. | {
"m": "Surveys and interviews: Reporting proportions",
"s": "539.28"
} | [
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... | W1973979946 | Method |
During hospitalization, 87.9 of patients were given a betablocker, 95.9 acetylsalicylic acid, 89.9 antithrombin therapy, 86.2 intravenous nitroglycerin, 6.4 glycoprotein GP IIbIIIa receptor inhibitor, 35.9 clopidogrel, 77.9 angiotensinconverting enzyme inhibitor, and 70,9 statin drugs. | {
"m": "Indicating the methodology for the current research",
"s": "442.62"
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-0... | W1973979946 | Method |
Coronary arteriography was performed in 72 patients 92.3 with STEMI, and in 452 59.8 with nonSTEMI ACS p 0.0001. | {
"m": "Surveys and interviews: Reporting proportions",
"s": "443.54"
} | [
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-0.1... | W1973979946 | Method |
Myocardial revascularization MR surgery was indicated for 12.9 and percutaneous coronary intervention for 26.6. | {
"m": "Restating a result or one of several results",
"s": "530.89"
} | [
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1.781... | W1973979946 | Result |
Inhospital mortality was 4.8, and no difference was recorded between the proportion of deaths among patients with STEMI and nonSTEMI ACS 6.4 versus 4.8 p 0.578. | {
"m": "Stating a negative result",
"s": "475.52"
} | [
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... | W1973979946 | Result |
In this registry, we provide a description of ACS patient, which allows the evaluation of the demographic characteristics, medical treatment prescribed, and inhospital mortality. | {
"m": "Outlining the structure of a thesis or dissertation",
"s": "476.54"
} | [
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... | W1973979946 | Other |
A greater awareness of our reality may help the medical community to adhere more strictly to the procedures set by guidelines. | {
"m": "Noting implications of the findings",
"s": "348.5"
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1.... | W1973979946 | Implications |
ABSTRACT We present an unusual tumorous variety of scleromyxedema mimicking facies leonina in lymphoma. | {
"m": "Outlining the structure of a short paper",
"s": "403.01"
} | [
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0.... | W2005484752 | Other |
In spite of pronounced and widespread cutaneous changes, hypergammaglobulinaemia and paraproteinaemia, the general condition of the patient was satisfactory, there was no internal involvement and no symptoms of any malignancy. | {
"m": "Stating a negative result",
"s": "410.99"
} | [
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0.6... | W2005484752 | Result |
Initially, melphalan and corticosteroids were applied but were not effective. | {
"m": "Describing the process: typical verbs in the passive form",
"s": "412.99"
} | [
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-1... | W2005484752 | Method |
Highdose intravenous immunoglobulin IVIG therapy had dramatic effect, and after five 5day monthly courses the tumours almost regressed and the skin became less hard. | {
"m": "Reporting positive and negative reactions",
"s": "412.91"
} | [
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0... | W2005484752 | Result |
After a further five courses in the following year there was complete clearance, which was sustained without any therapy for 1 year until now. | {
"m": "Restating a result or one of several results",
"s": "482.24"
} | [
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0... | W2005484752 | Result |
IVIG appears to be the therapy of choice for scleromyxedema. | {
"m": "Suggesting general hypotheses",
"s": "480.84"
} | [
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0.953... | W2005484752 | Hypothesis |
We stress, however, that at the start of therapy, IVIG applications should be supplemented with small doses of melphalan andor corticosteroids. | {
"m": "Advising cautious interpretation of the findings",
"s": "419.68"
} | [
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1.... | W2005484752 | Limitations |
Chemischer InformationsdienstVolume 16, Issue 3 Preparative Organic Chemistry ChemInform Abstract PHOTOCHEMISTRY OF NAROYLANTHRANILIC ACIDS T. NAITO, T. NAITOSearch for more papers by this authorI. | {
"m": "Describing what other writers do in their published work",
"s": "428.56"
} | [
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0.3187759518623352,... | W2016608693 | Method |
NINOMIYA, I. NINOMIYASearch for more papers by this author T. NAITO, T. NAITOSearch for more papers by this authorI. | {
"m": "Describing what other writers do in their published work",
"s": "505.06"
} | [
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NINOMIYA, I. NINOMIYASearch for more papers by this author First published January 22, 1985 httpsdoi.org10.1002chin.198503114Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare fulltext accessPlease review our Terms and Condit... | {
"m": "Referring to secondary sources",
"s": "447.83"
} | [
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0.1224262267351150... | W2016608693 | Background |
I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a fulltext version of this article with your friends and colleagues. | {
"m": "Referring to the literature to justify a method or approach ",
"s": "596.55"
} | [
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... | W2016608693 | Purpose |
Learn more. | {
"m": "Suggesting implications for what is already known",
"s": "606.42"
} | [
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... | W2016608693 | Implications |
Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. | {
"m": "Noting the lack of or paucity of previous research",
"s": "558.28"
} | [
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Volume16, Issue3January 22, 1985 RelatedInformation | {
"m": "Referring to important texts in the area of interest",
"s": "546.42"
} | [
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... | [
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-0.9153784513473511,... | W2016608693 | Background |
An automated recognition technique was proposed for providing information on such as the skeleton of thoracic aorta, diameter of each crosssection along the skeleton, curvature of it and position of the aneurysm on the aorta using multislice CT images. | {
"m": "Describing the research design and the methods used",
"s": "349.07"
} | [
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-0.... | W1581785689 | Method |
The information was indispensable to design a stent with perfect fitting to the patients aorta aneurysm region so that the stent kept the original position against the blood stream. | {
"m": "Pointing out interesting or important findings",
"s": "555.79"
} | [
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1.7284497022628784,
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... | W1581785689 | Result |
The proposed technique was based on the fact that crosssections of the aorta aneurysm region had deformation from circular shape while those of the normal region had circular shape due to blood pressure. | {
"m": "Explaining the provenance of the participants",
"s": "356.1"
} | [
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0.75... | [
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-0.... | W1581785689 | Method |
The threedimensional shape of the aorta was extracted by applying an algorithm Successive Region Growing. | {
"m": "Describing the process: typical verbs in the passive form",
"s": "465.85"
} | [
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0.7793644070625305,... | W1581785689 | Method |
Cylinder model fitting well reduced noise and enabled us to detect the deformation with high accuracy. | {
"m": "Pointing out interesting or important findings",
"s": "430.22"
} | [
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1.448548... | W1581785689 | Result |
Skeleton and diameter of the aorta were obtained from the resultant fitting circle. | {
"m": "Describing the process: typical verbs in the passive form",
"s": "492.1"
} | [
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... | [
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The proposed technique was successfully applied to actual 90 slice of patient multislice CT data. | {
"m": "Surveys and interviews: Reporting proportions",
"s": "457.68"
} | [
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0.... | W1581785689 | Method |
Pseudomonas aeruginosa biofilm formation was increased by addition of sucrose to LuriaBertani medium, whereas addition of NaCl to a final similar osmolarity and use of maltose instead of sucrose, were ineffective. | {
"m": "Indicating methodological problems or limitations",
"s": "553.95"
} | [
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-... | W2123797961 | Limitations |
In a previous study, we showed that the extracytoplasmic sigma factor SigX is activated in the presence of sucrose. | {
"m": "Referring to a single investigation in the past: investigation prominent",
"s": "381.77"
} | [
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1.5391547679901123,
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... | W2123797961 | Background |
The sucrosemediated pellicle increase was abolished in a sigX mutant strain. | {
"m": "Reporting positive and negative reactions",
"s": "538.79"
} | [
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... | [
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1.8064864873886108,
0.41167184710502625,
-0.8942657113075256,
1.... | W2123797961 | Result |
Sucrose addition led to an increase in pel expression and cyclicdiguanylate cdiGMP pool level production. | {
"m": "Reporting positive and negative reactions",
"s": "382.76"
} | [
0.6282609105110168,
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0.8778857588768005,
2.2691659927368164,
0.26763975620269775,... | [
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-1.3404446840286255,
1.8011921644210815,
0.8684348464012146,
0.08564669638872147,
... | W2123797961 | Result |
Interestingly, these two phenotypes were strongly decreased in a sigX mutant. | {
"m": "Reporting positive and negative reactions",
"s": "417.13"
} | [
0.7685446739196777,
0.39168521761894226,
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1.530755877494812,
1.5663312673568726,
0.9675222039222717,
0.46... | [
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-0.5521613359451294,
1.0316308736801147,
0.3195258378982544,
0.9628278017044067,
0.... | W2123797961 | Result |
Since pel is not known as a SigXtarget, we suspect SigX to be involved in the cdiGMP production. | {
"m": "Suggesting general hypotheses",
"s": "442.74"
} | [
0.22613495588302612,
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0.9240499138832092,
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0.692909300327301,
1.0831882953643799,
-0.4594452679157257,... | [
2.094560146331787,
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0.9042516946792603,
1.4604783058166504,
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0.8057419061660767,
0.26... | W2123797961 | Hypothesis |
We found that expression of the diguanylate cyclase PA4843 gene was increased in the presence of sucrose at least partly through SigX activity. | {
"m": "Summarising the results section",
"s": "357.28"
} | [
0.9128785133361816,
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1.029489517211914,
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... | [
1.4742257595062256,
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0.15491798520088196,
0.41435331106185913,
0.8720669150352478,
-0.05031060427427292,
... | W2123797961 | Result |
Our study shows that sucrose itself rather than osmolarity favours the biofilm mode of P. aeruginosa through the activation of SigX. | {
"m": "Offering an explanation for the findings",
"s": "343.57"
} | [
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... | W2123797961 | Result |
In Shakespeares drama Mikebai he reflected the new social evil of the Renaissance times by revising early chronicle. | {
"m": "Some ways of introducing quotations",
"s": "587.34"
} | [
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... | W2349757815 | Result |
The peculiar individual psychology trait of Mikebai was deeply and carefully depicted. | {
"m": "Commenting on the strengths of the current study",
"s": "559.89"
} | [
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... | [
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0... | W2349757815 | Result |
The fight between goodness and badness of characters and fierce conflict of justice and evil was showed. | {
"m": "Restating a result or one of several results",
"s": "465.5"
} | [
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... | [
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1.... | W2349757815 | Result |
The inevitable tragedy destiny and essence was revealed. | {
"m": "Describing the process: typical verbs in the passive form",
"s": "605.48"
} | [
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1.0424208641052246,
1.3126068... | [
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3.0... | W2349757815 | Method |
The transformation was sucessfully finished. | {
"m": "Restating a result or one of several results",
"s": "482.17"
} | [
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0.5763763785362244... | W2349757815 | Result |
This article presents the analysis of the Implementation Program of Multifunctional Resources Room, addressing modes of constitution of this policy and data about the enrollment of students with disabilities and offering of the Specialized Educational Service in Rio Grande do Sul. | {
"m": "Describing the research design and the methods used",
"s": "457.93"
} | [
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... | W1525146318 | Method |
The methodology was based on reading of the normative documents, of theoretical and methodological referential of analysis and evaluation of public policies and setting up school census data of 2009, 2010 and 2011, which show a significant increase in enrollment of students in SES and in the public school system of the... | {
"m": "Indicating the methodology for the current research",
"s": "381.88"
} | [
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2.6635117530822754,
0.39079174399375916,
-0.... | W1525146318 | Method |
Private forprofit institutions have been the fastest growing part of the U.S. higher education sector. | {
"m": "Summarising the literature review",
"s": "425.76"
} | [
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0.788311779499054,
0.07229418307542801,
1.030... | W1512056244 | Other |
Forprofit enrollment increased from 0.2 percent to 9.1 percent of total enrollment in degreegranting schools from 1970 to 2009, and forprofit institutions account for the majority of enrollments in nondegree granting postsecondary schools. | {
"m": "Highlighting interesting or surprising results",
"s": "435.24"
} | [
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... | [
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0.3933153748512268,
1.8342875242233276,
0.10659092664718628,
1.0... | W1512056244 | Result |
We describe the schools, students, and programs in the forprofit higher education sector, its phenomenal recent growth, and its relationship to the federal and state governments. | {
"m": "Describing the characteristics of the participants",
"s": "511.79"
} | [
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... | [
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2.3559517860412598,
0.03955553099513054,
1.5436028242111206,
0.954606354236602... | W1512056244 | Method |
Using the 2004 to 2009 Beginning Postsecondary Students BPS longitudinal survey, we assess outcomes of a recent cohort of firsttime undergraduates who attended forprofits relative to comparable students who attended community colleges or other public or private nonprofit institutions. | {
"m": "Giving reasons why a particular method was adopted",
"s": "472.48"
} | [
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-0... | W1512056244 | Purpose |
We find that relative to these other institutions, forprofits educate a larger fraction of minority, disadvantaged, and older students, and they have greater success at retaining students in their first year and getting them to complete short programs at the certificate and AA levels. | {
"m": "Offering an explanation for the findings",
"s": "429.66"
} | [
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0.23310081660747528,
0... | W1512056244 | Result |
But we also find that forprofit students end up with higher unemployment and idleness rates and lower earnings six years after entering programs than do comparable students from other schools, and that they have far greater student debt burdens and default rates on their student loans. | {
"m": "Summarising the results section",
"s": "541.16"
} | [
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0.1... | [
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0.7645760178565979,
2.0473082065582275,
-0.0953867062926292... | W1512056244 | Result |
The mammalian Target of Rapamycin mTOR nutrientsensing pathway plays a fundamental role in cell growth, and proliferation, as well as in tumor metabolism. | {
"m": "Establishing the importance of the topic for the discipline",
"s": "481.85"
} | [
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... | [
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2... | W2236282264 | Importance |
mTOR is the catalytic subunit that nucleates two functionally and structurally distinct complexes namely mTORC1 mammalian Target of Rapamycin Complex 1 and mTORC2 mammalian Target of Rapamycin Complex 2. | {
"m": "Outlining the structure of a thesis or dissertation",
"s": "454.28"
} | [
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2.5637993812561035,
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... | [
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0.6139970421791077,
1.3013834953308105,
-0.34982925653457... | W2236282264 | Other |
mTORC1 integrates inputs from nutrients, growth factors, and environmental cues and transduces signals to downstream targets to promote anabolism and decrease catabolism. | {
"m": "Describing the process: typical verbs in the passive form",
"s": "444.18"
} | [
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0... | [
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1.7049363851547241,
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1.0140334367752075,
... | W2236282264 | Method |
As such, mTORC1 is considered a master regulator of metabolism, cell growth, and proliferation. | {
"m": "Establishing the importance of the topic for the discipline",
"s": "534.56"
} | [
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3.089881658554077,
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... | [
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1.5526915788650513,
1.283696174621582,
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0.5817174911499023,
... | W2236282264 | Importance |
mTORC1 is activated by PI3K phosphoinositide 3kinasesAktPKB protein kinase B and Ras ERK extracellular signalregulated kinase pathways, both of which are the most common oncogenic signaling pathways activated in cancer. | {
"m": "Describing the process: typical verbs in the passive form",
"s": "408.63"
} | [
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0.9711265563964844,
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2.2255187034606934,
0.607236921787262,
-... | [
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1.9063578844070435,
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0.2556859850883484,
1.1424535512924194,
1.5863176584243774,
... | W2236282264 | Method |
Recently, mTORC2 emerged as an important contributor to cellular and tumormetabolism. | {
"m": "Restating a result or one of several results",
"s": "535.38"
} | [
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mTORC2 receives inputs mainly from growth factors and regulates the organization of actin cytoskeleton, cell survival, and cellular metabolism. | {
"m": "Describing the process: typical verbs in the passive form",
"s": "434.46"
} | [
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... | W2236282264 | Method |
This review focuses on the role of mTORC2 in cellular metabolism and cancer metabolism. | {
"m": "Stating the focus, aim, or argument of a short paper",
"s": "431.44"
} | [
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1.262742280960083,
0.2600689828395843... | W2236282264 | Hypothesis |
Understanding the underpinning of mTORC2 signaling and targeting both mTORC1 and mTORC2 complexes, holds promise for regimens in cancer early detection, monitoring, and treatment. | {
"m": "Implications and/or recommendations for practice or policy",
"s": "285.3"
} | [
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... | W2236282264 | Reccomendations |
BautechnikVolume 80, Issue 12 p. 932932 Termine Österreichischer Betontag 2004 First published 02 April 2013 httpsdoi.org10.1002bate.200306350AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare fulltext accessPlease review our Terms and Conditi... | {
"m": "Explaining the provenance of articles for review",
"s": "410.51"
} | [
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I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a fulltext version of this article with your friends and colleagues. | {
"m": "Referring to the literature to justify a method or approach ",
"s": "596.55"
} | [
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... | W4240097692 | Purpose |
Learn more. | {
"m": "Suggesting implications for what is already known",
"s": "606.42"
} | [
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... | [
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... | W4240097692 | Implications |
Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. | {
"m": "Noting the lack of or paucity of previous research",
"s": "558.28"
} | [
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0.0... | [
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-0.0041683427989482... | W4240097692 | Uncertainty |
Volume80, Issue12December 2003Pages 932932 RelatedInformation | {
"m": "Referring to data in a table or chart",
"s": "514.09"
} | [
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0.7049604654312134,
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Tea culture,which has a long history,has close relationship with tourism. | {
"m": "Establishing the importance of the topic for the discipline",
"s": "469.84"
} | [
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1.... | W1414027971 | Importance |
The study aimed to discuss the important approaches and main manifestation of the inheriting and promotion of tea culture by tourism,and put forward several measures for better utilizing tourism industry to promote the development of tea culture in China | {
"m": "Referring back to the research aims or procedures",
"s": "522.59"
} | [
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0.... | W1414027971 | Aims |
The desire of knowledge, one of mans most important goals, there are also mixed wishes of other type, like ambition or competition, which can deviate him from his uninterested objectives. | {
"m": "Establising the importance of the topic as a problem to be addressed",
"s": "359.94"
} | [
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1.... | W2464399353 | Importance |
That is why there are many people who throw a suspect on this libido sciendi that has become a libido dominandi where the legal valorization of power and the idolatry of progress are combined. | {
"m": "Establising the importance of the topic as a problem to be addressed",
"s": "480.89"
} | [
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It will be the ethic comisions or comites to play a calming function that can work as a boundary to this cultural anguish. | {
"m": "Implications and/or recommendations for practice or policy",
"s": "490.25"
} | [
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... | W2464399353 | Reccomendations |
However, these possible deviations must not only be atributed to the desire of knowing in itself, but to the social system, which, troughout the institutions, compels investigators to compete among themselves with projects and publications, and obliges them to enter either into an economic competition or into an intern... | {
"m": "Implications and/or recommendations for practice or policy",
"s": "456.6"
} | [
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0.897... | W2464399353 | Reccomendations |
As members of a scientific comunity, with its own interests, it is necessary for us to defend the autonomy of this libido cognoscendi in front of those who take social decisions, in the measure that economical resources for investigation depend on them. | {
"m": "Establising the importance of the topic as a problem to be addressed",
"s": "545.16"
} | [
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Uninterested investigation is still very important for the cultural wellfare of society, but it is important to be on guard, as man is not only in the centre of investigations, but also of its applications. | {
"m": "Establising the importance of the topic as a problem to be addressed",
"s": "278.67"
} | [
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1.5... | W2464399353 | Importance |
We address the task of targeted sentiment as a means of understanding the sentiment that students hold toward courses and instructors, as expressed by students in their comments. | {
"m": "Providing background information: reference to the purpose of the study",
"s": "530.29"
} | [
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We introduce a new dataset consisting of student comments annotated for targeted sentiment and describe a system that can both identify the courses and instructors mentioned in student comments, as well as label the students sentiment toward those entities. | {
"m": "Indicating the methodology for the current research",
"s": "457.88"
} | [
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1.9030046463012695,
... | W2572212662 | Method |
Through several comparative evaluations, we show that our system outperforms previous work on a similar task. | {
"m": "Transition: moving to the next result",
"s": "473.74"
} | [
0.476155161857605,
1.5262115001678467,
-3.5761008262634277,
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0.7025728821754456,
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0.9846562743186951,
-0.20229971408843994,
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0.21209940314292908,
0.9608035683631897,
0.4050958454608917,
1.7401902675628662,
0.8216120004653931,
-0... | [
1.811051607131958,
0.2401103973388672,
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1.0980825424194336,
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0.7465981841087341,
0.8680920004844666,
0.5450693368911743,
2.7924599647521973,
-0.18... | W2572212662 | Result |
Excore neutron detector noise has been utilized to monitor core support barrel CSB vibrations. | {
"m": "Describing the process: typical verbs in the passive form",
"s": "433.69"
} | [
1.836767315864563,
1.0662429332733154,
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1.0993629693984985,
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-0.7283881306648254,
1.5366815328598022,
-0.22727888822555542,
0.8740637898445129,
... | [
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1.0446110963821411,
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0.3374776542186737,
0.09846683591604233,
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1.1748420000076294,
0.5578930974006653,
1.8041614294052124,
0.8... | W1483471382 | Method |
In order to observe longterm changes, noise signals at Sequoyah1 were monitored continuously during the whole first fuel cycle and part of the second cycle. | {
"m": "Describing the process: infinitive of purpose",
"s": "429.02"
} | [
0.4194165766239166,
-0.883057713508606,
-4.193748950958252,
-1.0964702367782593,
0.6322530508041382,
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0.9947143793106079,
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0.5355610251426697,
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1.1264727115631104,
1.7222516536712646,
2.2274866104125977,
0.... | [
0.7380876541137695,
0.7762753367424011,
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1.4251351356506348,
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1.0208178758621216,
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0.245010644197464,
1.159967303276062,
-0.7910505533218384,
0.6656576991081238,
0.716160774230957,
1.1023367643356323,
0.1800... | W1483471382 | Method |
Results suggest that neutron noise measurements performed infrequently may not provide adequate surveillance of the CSB because it may be difficult to separate noise amplitude changes due solely to CSB motion from changes caused by fuel motion and burnup. | {
"m": "Suggesting general hypotheses",
"s": "392.76"
} | [
1.2339857816696167,
0.661738932132721,
-3.2077364921569824,
-0.2228015959262848,
1.1341562271118164,
0.6251968741416931,
0.3595457673072815,
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1.7126084566116333,
0.5219023823738098,
1.7979997396469116,
0.09... | [
0.8625147342681885,
0.8514771461486816,
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0.8910623788833618,
1.0760828256607056,
-1.0784049034118652,
1.6484156847000122,
0.5... | W1483471382 | Hypothesis |
DLC | {
"m": "Describing what other writers do in their published work",
"s": "627.41"
} | [
0.38649529218673706,
-0.6221061944961548,
-3.6292595863342285,
-0.8969835638999939,
0.3499816954135895,
0.184102863073349,
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0.9378525018692017,
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-0.6157833933830261,
1.0282983779907227,
1.8304767608642578,
0.9993985891342163,
0.... | [
0.5186730027198792,
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-0.5780943036079407,
0.6881387829780579,
0.9586741924285889,
0.49501943588256836,
... | W1483471382 | Method |
The protein arginine deiminases PADs are a family of Ca2dependent enzymes that catalyze the conversion of peptidylarginine to peptidylcitrulline in numerous protein substrates. | {
"m": "Explaining keywords (also refer to Defining Terms)",
"s": "416.45"
} | [
0.5008812546730042,
0.9195312857627869,
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-0.45701155066490173,
1.1418050527572632,
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-0.5972870588302612,
0.2805800437927246,
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-1.6533445119857788,
-0.19544847309589386,
1.3773531913757324,
1.1708606481552124,
-0.06707560271024704... | [
0.4615849256515503,
0.01995626650750637,
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1.3479628562927246,
0.7431439757347107,
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0.3095470368862152,
-0.4930088520050049,
0.8205215930938721,
-1.0941232442855835,
... | W167094391 | Keywords |
Disruption of normal PAD activity plays a role in the pathogenesis of multiple inflammatory diseases such as rheumatoid arthritis RA, chronic obstructive pulmonary disease, ulcerative colitis, multiple sclerosis, psoriasis, Alzheimers disease, and in various cancers. | {
"m": "Establishing the importance of the topic for the world or society",
"s": "420.2"
} | [
1.012452244758606,
1.1475650072097778,
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1.3664629459381104,
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1.667725920677185,
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0.7155603766441345,
0.8609419465065002,
1.350809931755066,
0.040870267897844315,
0.441... | [
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2.064558744430542,
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-0.6434171199798584,
0.4603351652622223,
-0.6068040132522583,
... | W167094391 | Importance |
PAD inhibitors described in the literature have been useful chemical tools to study the role of PAD enzymes in inflammatory diseases and cancer biology. | {
"m": "Referring to previous work to establish what is already known",
"s": "452.17"
} | [
0.5705836415290833,
1.123416781425476,
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1.293537974357605,
1.9801290035247803,
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0.59... | [
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0.6643775105476379,
0.26835814118385315,
-0.6593027710914612,
0.582874059677124,
... | W167094391 | Background |
Most published PAD inhibitors are mechanismbased inactivators belonging to the halogenamidine chemotype. | {
"m": "Stating what is currently known about the topic",
"s": "566.2"
} | [
0.229092538356781,
0.6705047488212585,
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0.2542870342731476,
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0.7360000014305115,
0.7015254497528076,
1.3799104690551758,
-0.42337939143180847,
1... | [
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0.5872048735618591,
0.7017751336097717,
-0.3395821452140808,
-0.03580119088292122,
... | W167094391 | Background |
For emerging targets such as the PADs, it can be difficult to distinguish compoundspecific effects from those truly resulting from enzyme inhibition. | {
"m": "Detailing specific limitations",
"s": "509.43"
} | [
-0.17778648436069489,
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0.7237008213996887,
1.905853033065796,
-0.2021653950214386,
0.63... | [
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0.7771259546279907,
1.263511061668396,
0.29779693484306335,
1.19448721408844,
0.16... | W167094391 | Limitations |
We therefore initiated a fluorescence polarization activitybased protein profiling fluopolABPP high throughput screening HTS campaign to identify a second PAD inhibitor chemotype. | {
"m": "Referring back to the research aims or procedures",
"s": "399.96"
} | [
0.6177886128425598,
0.27541205286979675,
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0.05928653106093407,
1.3538453578948975,
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0.3181712031364441,
1.480236530303955,
1.8720382452011108,
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0.... | [
0.05648636817932129,
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1.3218507766723633,
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1.0153011083602905,
0.2031748741865158,
2.1910481452941895,
1.1217901706695557,
0.0... | W167094391 | Aims |
The PAD4 HTS campaign identified the natural product streptonigrin SID 11532976 as an irreversible PAD4specific inhibitor. | {
"m": "Restating a result or one of several results",
"s": "480.82"
} | [
0.48258739709854126,
1.2240992784500122,
-3.5370306968688965,
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0.31223833560943604,
0.5222594141960144,
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0.3298429846763611,
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0.06846506148576736,
-0.1992371380329132,
0.9895308017730713,
0.5914719700813293,
-0.542223811149597... | [
1.5779061317443848,
-0.058711130172014236,
-2.3857839107513428,
0.05773751437664032,
2.0609986782073975,
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0.6181915998458862,
0.22838084399700165,
1.2964600324630737,
0.00284755323082208... | W167094391 | Result |
We describe herein the medicinal chemistry optimization of streptonigrin to the pan PAD probe ML325 SID 118043677. | {
"m": "Outlining the structure of a thesis or dissertation",
"s": "441.54"
} | [
0.3113526999950409,
0.9556401371955872,
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0.4697519540786743,
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0.4780680239200592,
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0.16753984987735748,
0.2780168354511261,
0.05594215542078018,
0.64201819896698,
1.3782684803009033,
-0.47812479734420776,
0... | [
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-0.5676535367965698,
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1.6366721391677856,
-0.58870929479599,
... | W167094391 | Other |
ML325 inhibits PAD1, 2, 3, and 4 in vitro with IC50 values of 70 nM, 200 nM 170 nM, and 240 nM respectively. | {
"m": "Indicating the methodology for the current research",
"s": "543.1"
} | [
-0.07450532913208008,
0.5493026375770569,
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0.048259980976581573,
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0.49589550495147705,
0.6357996463775635,
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-0.5934263467788696,
0.9405905604362488,
1.3620611429214478,
-0.778771162033081... | [
0.3138115406036377,
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2.582563638687134,
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0.43565088510513306,
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-0.5742509961128235,
0.5055264234542847,
-0.773942232131958,
0.5082467198371887,
1.19697904586792,
-0.912743866443634,
0.441... | W167094391 | Method |
In a kinetic assay of inhibition more appropriate for irreversible inhibitors, ML325 has kinactKI values of 3500, 7300, 1900, and 5300 M1min1 for PAD1, 2, 3 and 4 respectively indicating it has less than 4fold selectivity among the four family members. | {
"m": "Transition: moving to the next result",
"s": "472.71"
} | [
0.366554319858551,
0.2539043426513672,
-2.9426398277282715,
0.3126368224620819,
0.5309475064277649,
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0.41347724199295044,
0.23062241077423096,
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0.42704376578330994,
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1.2678898572921753,
1.505466341972351,
-0.27924108505249023,
-... | [
0.05936563387513161,
1.9095022678375244,
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2.201183319091797,
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0.5815253853797913,
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-0.5459083914756775,
-0.11001002788543701,
1.4436519145965576,
-0.23245230317115784,
... | W167094391 | Result |
Despite its promiscuity within the PAD family, ML325 exhibits high selectivity vs. more than 20 cysteinereactive proteins as assayed by activitybased protein profiling. | {
"m": "Reporting positive and negative reactions",
"s": "459.69"
} | [
0.24020081758499146,
1.3625138998031616,
-2.6480536460876465,
0.17339369654655457,
0.9584799408912659,
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0.6016363501548767,
0.18976731598377228,
0.3235107362270355,
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-1.2598721981048584,
0.8480188250541687,
2.0899345874786377,
-0.46746885776519775,
... | [
1.2151281833648682,
0.8742012977600098,
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0.7411578893661499,
0.9966158270835876,
0.882770836353302,
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-1.8359721899032593,
0.578701376914978,
-1.1280746459960938,
-0.8208147883415222,
1.1315202713012695,
0.4454457461833954,
0.18279509246349335,
0.20... | W167094391 | Result |
ML325 was also demonstrated to inhibit all four PAD isozymes irreversibly and to be noncytotoxic to NIH3T3 cells. | {
"m": "Restating a result or one of several results",
"s": "465.35"
} | [
0.7924367785453796,
0.4225427508354187,
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0.1572371870279312,
0.2759968638420105,
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0.9614808559417725,
0.19654567539691925,
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-1.3491765260696411,
0.7372459173202515,
1.3618043661117554,
-0.5793038010597229,
... | [
2.2159013748168945,
0.177514910697937,
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1.439455270767212,
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1.018718957901001,
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0.5341690182685852,
-0.7490363717079163,
1.0422866344451904,
0.6223224401473999,
2.... | W167094391 | Result |
The complete properties, characterization, and synthesis of ML325 are detailed in this report. | {
"m": "Outlining the structure of a thesis or dissertation",
"s": "507.44"
} | [
0.5793389081954956,
0.3779624402523041,
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0.36080414056777954,
1.9776480197906494,
-0.8612983822822571,
... | [
1.1287850141525269,
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-1.4147233963012695,
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0.28640198707580566,
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-1.0625653266906738,
-0.6488965153694153,
1.3886210918426514,
0.6209090948104858,
0.18262596428394318... | W167094391 | Other |
Our website uses cookies to enhance your experience. | {
"m": "Indicating criteria for selection or inclusion in the study",
"s": "522.67"
} | [
-0.23179946839809418,
2.1930735111236572,
-3.879296064376831,
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0.5497287511825562,
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0.584718644618988,
0.8346013426780701,
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1.158560872077942,
0.2636134922504425,
1.005981206893921,
1.3340152502059937,
-1.... | [
0.762166440486908,
0.7219323515892029,
-1.5449059009552002,
0.09857998043298721,
1.079266905784607,
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1.4329276084899902,
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0.23459817469120026,
0.5313149094581604,
0.36136725544929504,
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-... | W2033573194 | Method |
By continuing to use our site, or clicking Continue, you are agreeing to our Cookie Policy Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngolog... | {
"m": "Making recommendations for further research work",
"s": "639.74"
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0.9... | W2033573194 | Reccomendations |
All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA OtolaryngologyHead Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology Psychiatry Input Sear... | {
"m": "Stating what is currently known about the topic",
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0.189593955874443... | W2033573194 | Background |
Sound localization presents a problem for animals with small heads closely spaced ears and poor highfrequency hearing. | {
"m": "Establising the importance of the topic as a problem to be addressed",
"s": "460.39"
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1... | W2030849760 | Importance |
In recent tests of spatial resolving power, several small songbirds i.e., great tit, canary, and zebra finch show rather large minimum audible angles MAA on the order of 1520 deg. | {
"m": "Referring to previous work to establish what is already known",
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... | W2030849760 | Background |
These results are expected if conventional binaural time and intensity differences are used. | {
"m": "Indicating an expected outcome",
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0.... | W2030849760 | Hypothesis |