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This article was written as an introduction to the journal by the editors; seeking to examine areas for future research into heritage tourism. The article is one of the most read and most cited of all the articles across the 9 volumes that have been published to date. The paper examined a range of what the authors call... |
The charge reduction of multiply charged macromolecular ions via recombination with small ions in the gas phase is commonly employed to modulate the charge on macromolecules prior to mass spectrometric and mobility analyses. We employ a recently developed continuum-Molecular Dynamics (MD) calculation approach to determ... |
A 62-year-old man presented with novel headache attacks with acute onset 4 weeks previously strictly confined to the right side. The attacks occurred almost daily, often after midnight, lasting 1 to 3 hours, occasionally longer. The pain was localized around and behind the right eye. The pain intensity was excruciating... |
In his personal history, the patient had had tension-type headache and mainly left-sided migraine-like headache attacks for many years. The latter were of a hammering quality, irradiating from the occipital to the frontal region, and accompanied by nausea, photophobia, and phonophobia. In comparison, the new onset curr... |
Family history revealed a twin brother, who died of aneurysmal subarachnoid hemorrhage 6 years previously. Several relatives had migraine. |
On clinical examination, reduced width of the palpebral fissure on the right side compared to the left (ptosis), right miosis, and anhidrosis of the forehead (figure 1, A and B) were noticed. These findings persisted during the pain-free interval. |
Figure 1 Complete right Horner triad |
(A) Right eye “ptosis” (or, more correct, reduced width of the palpebral fissure on the right side compared to the left) and miosis. (B) Right forehead anhidrosis, visualized using ponceau dye. |
### Questions for consideration: |
1. How would you classify these new onset headache attacks? |
2. Are there any atypical features or red flags pointing to a secondary headache? |
GO TO SECTION 2 |
At first glance, the patient's complaints and clinical findings match the criteria of the International …“ There is a lot of good doctors out there ” : Women with HIV Talk About their Doctors |
Since the initial reports of the disease were made available, Acquired Immune Deficiency Syndrome (AIDS), a life-threatening condition caused by the human immunodeficiency virus (HIV) has become a global epidemic. Today, many people with HIV are living longer and women represent a growing proportion of HIV/AIDS cases i... |
Since 2005, labour productivity growth in Ontario’s business sector has been zero, greatly under-performing the rest of Canada and being single-handedly responsible for most of what has been described as “Canada’s dismal productivity growth.” This article examines the issue through detailed sectoral data, and finds a w... |
The research of the flow simulation in the inner stirring tank with the single pipe and dual pipe was studied by CFD, which has demonstrated the fluid simulation effect of the single pipe and dual pipe. It has found that the effect is better in the single pipe stirring tank than the dual pipe one. Basing on this result... |
Smart grid pilot projects require a representative subset of the total population to draw relevant conclusions from test results. However, customers willing to participate in such projects are not always representative to the whole population. Standard random sampling gives some problems because not all results can be ... |
During recent years the biochemical aspects of immunological reactions have attracted considerable interest, and progress in this field is rapid. Among other things, research has concentrated on the biochemical role of fatty acids and lipoproteins in certain immune reactions, in this article we review the immunoregulat... |
Testing for mutation in BRCA genes is widely used to identify women at high risk for a familial or inherited predisposition to breast cancer. The increased risk of developing breast cancer during a lifetime as a result of a mutation in a BRCA gene is estimated at 45% to 84% and also carries with it a high risk of a sec... |
Previous studies suggest that the risk of nonsyndromic cleft lip with or without cleft palate (CL+/-P) and isolated cleft palate (CP) is influenced by genetic variation at several loci and that the relation between specific genetic variants and disease risk may be modified by environmental factors. The present study ev... |
(2) Incorrect unit of ISI composite . Correct unit of ISI composite is [L 2 mg − 1 μ U − 1 10 − 4 ], which substitutes [L 2 mg − 1 μ U − 1 ]. (3) Incorrect absolute value of B total . The specific value of B total must be multiplied by the constant [3·08 × 10 − 3 ]. The corrections of ISI composite and B total do not i... |
Twenty-two diurnally active, fair-skinned, male volunteers were repeatedly patch tested with 10, 15 and 20% lapyrium chloride (LC) and 0.3 and 0.5% sodium lauryl sulfate (SLS) for 5 consecutive days. A series of 5 patches containing SLS and LC were placed vertically once daily for 6 h on different sites of the scapula:... |
We have previously shown that the delta E3 site is an essential element for transcriptional activation by the human T-cell receptor (TCR) delta enhancer and identified two factors, NF-delta E3A and NF-delta E3C, that bound to overlapping core (TGTGGTTT) and E-box motifs within delta E3. In this study, we show that prot... |
Data analytics for streaming sensor data brings challenges for the resource efficiency of algorithms in terms of execution time and the energy consumption simultaneously. Fortunately, optimizations which reduce the number of CPU cycles also reduce energy consumption. When reviewing the specifications of processing unit... |
Microglia are the resident immune cells that constantly survey the central nervous system. They can adapt to their environment and respond to injury or insult by altering their morphology, phenotype, and functions. It has long been debated whether microglial activation is detrimental or beneficial in multiple sclerosis... |
A 74-year-old man presented with chest pain, dry cough, progressive respiratory distress and infiltrative lung shadow. Diagnosis of acute eosinophilic pneumonia was confirmed by histological examination as well as clinical features. On the 8th day post-admission, he developed progressive generalised muscle weakness tha... |
ABSTRACT This paper investigates why firms choose the conservative financing strategy known as non-positive net debt policy, which is a more recent prevalent trend among Japanese firms. The analysis reveals that Japanese firms are more likely to be financially conservative if they are smaller, older and more profitable... |
This research is investigating the feasibility of using computer vision to provide a level of situational awareness suitable for the task of UAV "sense and avoid." This term is used to describe the capability of a UAV to detect airborne traffic and respond with appropriate avoidance maneuvers in order to maintain minim... |
This study investigated the factors that members of organizational work teams believe facilitate and inhibit group performance effectiveness. This objective was pursued via two research questions: (1) What do group members identify as facilitative and inhibitive influences on group progress? and (2) Are these perceived... |
In elementary probability and statistics classes, a common example is the “Birthday Problem”: In a group of people, what is the probability that at least two people have the same birthday? After the probability has been calculated, it is natural to look for a match by having students announce their birthdays one by one... |
Many task models, task analysis methods, and supporting tools have been introduced in the literature and are widely used in practice. With this comes need to understand their scopes and their differences. This chapter provides a thorough review of selected, significant task models along with their method and supporting... |
BACKGROUND |
Diagnosing periprosthetic joint infection (PJI) represents a challenge that relies on multiple clinical and laboratory criteria that may not be consistently present. The synovial alpha-defensin-1 (AD-1) test has been shown to correlate accurately with the Musculoskeletal Infection Society (MSIS) criteria for the diagno... |
QUESTIONS/PURPOSES |
(1) Can the AD-1 test determine whether infection has been controlled using the Delphi criteria for persistent PJI as a surrogate for infection eradication during two-stage revision for PJI treatment with a spacer? (2) How does the performance of the AD-1 test compare with the MSIS criteria? |
METHODS |
This was a multicenter analysis of retrospectively collected data on patients who underwent a two-stage revision arthroplasty between May 2014 and July 2016. We included patients who had a previously confirmed PJI and received a cement spacer, underwent the second stage, had MSIS criteria data and a synovial fluid AD-1... |
RESULTS |
The AD-1 test showed poor sensitivity (7%; 95% CI, 0.2-34), and poor overall accuracy (73%; 95% CI, 60-83; AUC = 0.5; 95% CI, 0.3-0.6) in detecting infection eradication at 1 year. The c-index for AD-1 versus Delphi criteria for persistent PJI was 0.519 (95% CI, 0.44-0.60), and the c-index for MSIS criteria versus Delp... |
CONCLUSIONS |
We found that a positive synovial fluid AD-1 test correlated poorly with the presence of persistent infection 1 year after two-stage revision arthroplasty for PJI. For this reason, we recommend against the routine use of AD-1 in patients with cement spacers, until or unless future studies demonstrate that the test is m... |
LEVEL OF EVIDENCE |
Level IV, diagnostic study.Sensorless vector control of permanent magnet synchronous motor using adaptive identification |
Vector controlled drives of a PMSM (permanent magnet synchronous motor) are proposed without position and speed sensor. The conventional pole position and speed sensors are eliminated by means of estimation using adaptive identification, for which stator voltages and currents are measured. To realize the proposed algor... |
A new architecture of cascaded sigma-delta modulators is presented. It is based on the combination of two algorithms, the Adaptive Integrator Bounding (AIB) and the Adaptive Interstage Coupling (AIC). The AIB concentrates on constraining the signal ranges within each stage, while the AIC eliminates the SNR degradation ... |
BACKGROUND |
Although it is well known that alcoholism increases long-term mortality, there is a paucity of data regarding long-term prognosis in alcoholic patients who have an episode of alcohol withdrawal syndrome (AWS). |
METHODS |
We studied a cohort of 1,265 individuals with severe AWS who were admitted to a single university hospital between 1996 and 2006. Median age was 49 years (range 18 to 89 years). A total of 1,085 (85.8%) were men. Median follow-up was 34 months (range 0 to 121 months). Survival of patients with AWS was compared with tha... |
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