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The 4F2 molecule belongs to the set of cell surface antigens which is induced following lectin- or antigen-mediated T-cell activation. The increase in 4F2 cell surface expression following lectin-mediated stimulation has been shown to be accompanied by a parallel increase in the steady-state levels of 4F2 heavy-chain (... |
In the event of an incident involving the release of hazardous material (eg, chemical, biological, radiological, or nuclear agents), key actions can be taken to reduce harm and protect the people involved. The quicker actions can be taken, the less harm will occur. Guidance is, therefore, needed to help nonspecialist m... |
The article examines transformational trends characteristic of the current stage of development of subjects of the transport and logistics sector, in particular enterprises of the railway transport. It is established that digital innovations are now considered as a key factor for successful adaptation of entities to ne... |
Acute Myeloid Leukemia (AML) is the most common myeloid leukemia in adults. Although substantial progress has been made in recent years, the long-term prognosis for patients remains poor which is mainly due to the dated treatments that consist of cytotoxic drugs with low specificity. AML is a clonal disease with multi... |
We aim to analyze the heterogeneous response to OTX015 in AML, and normal stem/progenitor, cells in order to dissect the BET-inhibitor response. The main focus is the specific transcriptional signatures at promoters and enhancers as enhancers, and especially super-enhancers, have previously been shown to be sensitive ... |
Clinical significance: Leukemic cell heterogeneity remains the main problem in AML, as chemotherapy often fails to completely eradicate all AML sub-clones including LSC, leading to relapses and high mortality of the disease. This study will shed light to the unique features of AML cell heterogeneity and how their drug... |
No relevant conflicts of interest to declare. |
Memory system energy: Influence of hardware-software optimizations |
A memory system usually consumes a significant amount of energy in many battery-operated devices. In this paper, we provide a quantitative comparison and evaluation of the interaction of two hardware cache optimization mechanisms (block buffering and sub-banking) and three widely used compiler optimization techniques (... |
In this paper, a novel fuzzy logic direct torque control (FLDTC) scheme combining with space voltage modulation (SVM) technique is presented. Using fuzzy logic technique, the reference space voltage vector can be obtained dynamically in terms of torque error, stator flux error and the angle of stator flux. Compared wit... |
In this work, we calculate the core structures of basal dislocations in graphite in a nanoscale continuum framework. The model consists of a stack of buffered Kirchhoff plates where the plates represent the covalent interactions within individual graphene sheets and the buffer layers represent the secondary interaction... |
This paper proposes a method for car detection in a calibrated system of camera and Laser Range Finder (LRF). The LRF sensor is used to extract the car candidates by a clustering method. Adjacent points sensed by the LRF are grouped together to form a car candidate. Those car candidates are then filtered out based on t... |
Each paper needs an abstract of up to 250 words. It should be structured as follows: Background/Aims: What is the major problem that prompted the study? Methods: How was the study carried out? Results: Most important fi ndings? Conclusion: Most important conclusion? Footnotes: Avoid footnotes. Tables and illustrations:... |
<p>Carbonaceous asteroids, which are minor bodies but enriched in water and organics, have been extensively explored by HAYABUSA2 and OSIRIS-REx recently because they are thought to be the major carrier of volatiles to the inner planets in our solar system. The recent explorations revealed that two carbonaceous asteroi... |
<p>  Hypervelocity impact experiments were performed with a two-stage light gas gun placed at Planetary Exploration Research Center of Chiba Institute of Technology, Japan. An Al<sub>2</sub>O<sub>3</sub> projectile with a diameter of 2 mm accelerated to two different impact velocities <em>v</em><sub>imp</sub> = 3.... |
<p>The experimental results are summarized as follows: (1) The total gas production was limited only to a few wt.% of the projectile mass even at the high <em>v</em><sub>imp</sub>, (2) the most abundant product was CO<sub>2</sub> in all the shots, (3) the chemical composition, including CO/CO<sub>2</sub> ratio and H<su... |
<p>Here, we discuss about the controlling mechanism of impact devolatilization. Since the carbon source in the CI simulant is only crushed coal grains, which is mixed into the CI simulant as an analog for insoluble organic matters, the detected C-bearing gases, which are CO and CO<sub>2</sub>, must be produced due to o... |
<p> </p> |
<p>Acknowledgements: This work was supported by ISAS/JAXA as a collaborative program with the Hypervelocity Impact Facility. We appreciate the developers of iSALE, including G. Collins, K. Wünnemann, B. Ivanov, J. Melosh, and D. Elbeshausen. We also thank Tom Davison for the development of the pySALEPlot.</p> |
<p> </p> |
<p>Key references:</p> |
<p>Amsden, A., Ruppel, H. & C. Hirt. SALE: A simplified ALE computer program for fluid flow at all speeds. <em>Los Alamos National Laboratories Report</em>, LA-8095:101p (1980).</p> |
<p>Collins, G. S., Elbeshausen, D., Davison, T. M., Wünnemann, K., Ivanov, B. A., and Melosh, H. J. iSALE-Dellen manual, <em>Figshare</em>, https://doi.org/10.6084/m9.figshare.3473690.v2 (2016).</p> |
<p>Hamilton, V. E. et al. Evidence for widespread hydrated minerals on asteroid (101955) Bennu. <em>Nature Astronomy</em> <strong>3</strong>, 332–340 (2019).</p> |
<p>Ivanov, B. A., Deniem, D. & Neukum G. Implementation of dynamic strength models into 2-D hydrocodes: Applications for atmospheric breakup and impact cratering. <em>Int. J. Impact Eng.</em> <strong>20</strong>, 411–430 (1997).</p> |
<p>Kitazato, K. et al. The surface composition of asteroid 162173 Ryugu from Hayabusa2 near-infrared spectroscopy, <em>Science</em> <strong>364</strong>, 272–275 (2019).</p> |
<p>Kurosawa, K., Moriwaki, R., Komatsu, G., Okamoto, T., Sakuma, H., Yabuta, H. & Matsui, T. Shock vaporization/devolatilization of evaporitic minerals, halite and gypsum, in an open system investigated by a two-stage light gas gun. <em>Geophysical Research Letters</em> <strong>46</strong>, 7258–7267 (2019).</p> |
<p>Schaefer, L., & Fegley, B. Jr. Redox states of initial atmospheres outgassed on rocky planets and planetesimals. <em>The Astrophysical Journal</em> <strong>843</strong>, 120 (2017).</p> |
<p>Tyburczy, J. A., Frisch, B., and Ahrens, T. J. Shock-induced volatile loss from a carbonaceous chondrite: implications for planetary accretion. <em>Earth and Planetary Science Letters</em> <strong>80</strong>, 201–207 (1986).</p>Divergent selection for shape of growth curve in Japanese quail. 5. Growth pattern... |
1. The effect of crude protein (CP) concentration in starter diet (259 or 216 g CP and 11·7 MJ ME/kg, fed from 0 to 21 d of age) on postnatal growth pattern (from hatching to 70 d of age) was analysed in Japanese quail lines divergently selected for high (HG) and low (LG) relative gain of body weight (BW) between 11 an... |
Progressive age-related oxidative phosphorylation (OxPhos) decline is well known in human tissues. Depletion of mitochondrial DNA (mtDNA) causes OxPhos defects in patients with myopathic syndromes and deficient mtDNA replication has been observed in cells cultured from patients with mitochondrial disease. Patients unde... |
EDITOR—In recent years many clinical guidelines on hypertension have been published. While recommendations have often varied, hypertension guidelines share two features: all have generated controversy and been poorly implemented. Recent criticisms of hypertension guidelines by the National Institute for Clinical Excell... |
HIV/AIDS has been a global health issue for decades, one which has often been accelerated by genocide and civil war. This paper analyzes the effectiveness of the international community in dealing with the growth of the HIV/AIDS crisis following a period of violence, by focusing on three different case studies: Uganda,... |
The SRAP molecular marker method was used to analyze the genetic diversity of 33 materials, and the yield and quality of some materials were identified. Molecular marker analysis showed that: 42 pairs of primer combinations were used to generate a total of 715 amplification bands, of which 320 bands were polymorphic, t... |
Pax-6 is expressed during early embryonic development of the eye. Very little is known about its expression in the functionally mature retina. We have detected Pax-6 transcripts in the ganglion cell- and amacrine cell layers at days 3, 10, 17 and 31 posthatching and in 2- to 3-month-old chick retina by in situ hybridiz... |
PURPOSE: A radio receiver for restraining reduction property of a low frequency signal and a method thereof are to restrain the reduction property of the low frequency signal generated when a capacitor is inserted into a communicating system to block a DC offset. CONSTITUTION: The first local oscillating portion(271) r... |
Reliability of functionally graded metal matrix composites (FGMMCs) for automotive components is still dependent on the detailed knowledge of the mechanisms of the microstructural build-up, for instance on the mechanisms leading to the distribution and relative positions of the reinforcing particles. In order to assess... |
The angular response of LWIR telescopes is measured to verify predicted off-axis rejection (OAR) performance. The data are also useful to guide any necessary modifications for performance improvement. The off-axis response must be 9 to 12 bels (orders of magnitude) below the on-axis maximum response to reject the influ... |
This paper aims to achieve improved control over the spray pattern in a wire arc torch by means of constructive measures to influence the flow dynamics. It focuses on evaluating different fluid dynamic designs of the spray torches with respect to the droplet trajectories and velocity distributions and the deposit dist... |
A group of doctors in India have criticised a proposed government order that bans health professionals from accepting gifts, travel, and hospitality from the drug industry but allows doctors’ associations and hospitals to continue accepting money from them. |
The Alliance of Doctors for Ethical Healthcare has asked the government to rewrite the new rules so as to stop associations from receiving industry funds and to end the practice of drug companies offering hospitals large discounts on drugs that they sell to patients at a profit. |
India’s department of pharmaceuticals is shortly due to finalise the new rules on the drug industry in India, although no date has been …Natural Language Interaction Using a Scalable Reference Dictionary |
A truly natural language interface to databases also needs to be practical for actual implementation. We developed a new feasible approach to solve the problem and tested it successfully in a laboratory environment. The new result is based on metadata search, where the metadata grow in largely linear manner and the sea... |
A new method of integrating passive components on large non-planar parts (example, automotive bumpers) using conductive spray inks and a shadow mask coupled with a damascene-like process is presented. The sprayed conductive ink acts as a catalyst for electro- or electroless-plating of copper. Structures with fine resol... |
The yeast Tap42 and mammalian alpha4 proteins belong to a highly conserved family of regulators of the type 2A phosphatases, which participate in the rapamycin-sensitive signaling pathway, connecting nutrient availability to cell growth. The mechanism of regulation involves binding of Tap42 to Sit4 and PPH21/22 in yeas... |
Expression of Mpl is restricted to hematopoietic cells in the megakaryocyte lineage and to undifferentiated progenitors, where it initiates critical cell survival and proliferation signals after stimulation by its ligand, thrombopoietin (TPO). As a result, a deficiency in Mpl function in patients with congenital amegak... |
Providing security for Dynamic Cluster based Mobile Ad-hoc networks (MANET) is a vital task to improve network security with less compromising mobility and with reduced dedicated Data occupancy. Key generation, distribution and authentication are major tasks of a key management system. A flexible and strong model is re... |
Single-walled carbon nanotube (SWNT) tips have been used to image nanostructures with high resolution. Studies of gold nanocrystal standards showed that SWNT tips provide a significant improvement in lateral resolution with respect to multi-walled nanotube tips and microfabricated Si tips. The nanotube tips were also u... |
Hemophagocytic syndrome (HPS) is a rare but serious complication that is associated with hypercytokinemia caused by activated T lymphocytes and macrophages in immunologically compromised patients. Living donor liver transplantation (LDLT) between adults has been performed to compensate for the shortage of available org... |
disease progression. The mRNA expression of CD71 was significantly higher in progressors than in non-progressors (P1⁄4 0.01). Immunnohistochemial study also confirmed the higher expression of CD71 in the former. In a multivariable Cox model adjusted for confounders, enhanced transcript level of CD71 was significantly a... |
In this study, we have characterized the HIV DNA-containing replication complexes present in cells early after cell-to-cell infection, using sucrose gradient sedimentation and immunoprecipitation. Six hours after cell-to-cell infection, a cytoplasmic HIV replication complex sedimented as a large structure (320S). This ... |
Objective To investigate the regulatory effect of post-translation modification of ribosomal protein S6 kinase 1 (S6K1) on the polyploidization of megakaryocytes. Methods SP600125, a c-Jun N-terminal kinase (JNK) inhibitor, and H-89, a cAMP-dependent protein kinase (PKA) inhibitor, were used to treat CMK cells separate... |
Understanding the hydrologic processes is the first step in making sound watershed management decisions including designing Best Management Practices for non-point source pollution control. Over the past fifty years, various forest experimental watersheds have been instrumented across the Carolinas through collaborativ... |
Abstract Purpose The main goal of this study is to discover the scientific evolution of Cancer-Related Symptoms in Complementary and Alternative Medicine research area, analyzing the articles indexed in the Web of Science database from 1980 to 2013. Design/Methodology/Approach A co-word science mapping analysis is perf... |
Two asymmetrical amphiphilic phthalocyanines simultaneously containing hydrophobic alkoxy and hydrophilic 15-crown-5-ether substituents at the phthalocyanine periphery H2{Pc(15C5)3[(OC8H[Formula: see text]]}(Pc-1) and H2{Pc(15C5)[(OC8H[Formula: see text]]}(Pc-2) and their symmetrical analogue H2[Pc(OC8H[Formula: see te... |
To the Editor: We thank Dr. Mancuso for the valuable comments on our manuscript regarding the long-term experience in patients receiving liver transplants for Budd-Chiari syndrome (BCS) associated with myeloproliferative neoplasms. In fact, the role of liver transplantation (OLT) in BCS has substantially changed over t... |
Statistical studies of galaxy-galaxy interactions often utilise net change in physical properties of progenitors as a function of the separation between their nuclei to trace both the strength and the observable timescale of their interaction. In this study, we use two-point auto, cross and mark correlation functions t... |
This paper is concerned with a recent microstructural approach to model creep crack growth. The model spans three different length scales, from the scale of individual cavities, through the grain scale up to the macroscopic scale of cracks in components and test specimens. In order to study the initial stages of creep ... |
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