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Introduction: X-linked agammaglobulinemia (XLA) is caused by a block in pre-B cell development due to a Bruton’s tyrosine kinase (BTK) gene mutation, leading to absence of CD19+ B cells and hypogammaglobulinemia. XLA affects males early in life, resulting in pyogenic infections and failure to thrive. We describe two at... |
For should we not always consider a work's starting point as a significant “lead” into our interpretation of the work's motivation? Thus…I would have the Decameron read, not as a series of hilarious stories, but as a series of hilarious stories told during a plague. –Kenneth Burke Mikhail Zoshchenko spent his literary ... |
Tosyl-triethylenetetramine-Sepharose (Tos-T-Sepharose) and carbenzoxytriethylenetetramine-Sepharose (Z-T-Sepharose) were found to be adsorbents utilizable in the purification of several microbial and animal proteases. The former Sepharose derivative adsorbed alpha-chymotrypsin, trypsin, subtilisin, thermolysin and neut... |
BACKGROUND & OBJECTIVE |
EP regimen[etoposide (VP-16) + cisplatin (DDP)] is a standard regimen for treatment of small cell lung cancer (SCLC), but the cure rate is still low. Teniposide (VM-26) is highly active single agent for SCLC as VP-16, and penetratable through blood-brain barrier. This clinical trial was designed to compare the efficacy... |
METHODS |
A total of 70 previously untreated SCLC patients without brain metastasis were included; 34 patients received VM-26 + DDP and 36 patients received EP. The characteristics of patients were comparable according to chi 2 test. |
RESULTS |
The overall response rate-was 76.5% for VM-26 + DDP group with 12 complete response (CR) and 14 partial response (PR), and 69.4% in the EP group with 12 CR and 13 PR (P = 0.595). The median duration of survival was 10.4 months for VM-26 + DDP group versus 9.8 months for EP group (P > 0.05). The 1, 2, and 5-year surviva... |
CONCLUSION |
VM-26 + DDP is a highly active regimen for treatment of SCLC; there is no difference in the effectiveness and toxicity versus EP regimen; VM-26 is possibly effective in prevention of brain metastasis in SCLC patients.[Effect of Temperature on ANAMMOX Process in Sequencing Batch Biofilm Reactors: Nitrogen Removal Perfor... |
For the ambient and low-temperature operation of the anaerobic ammonium oxidation (ANAMMOX) process, sequence batch biofilm reactors (SBBR) with non-woven fabric and modified polyurethane foam as carriers, respectively, were used to treat nitrogenous wastewater. Nitrogen removal performances of both reactors were inves... |
Purpose |
The purpose of this paper is to discuss how, despite increasing data availability from a wide range of sources unlocks unprecedented opportunities for disaster risk reduction, data interoperability remains a challenge due to a number of barriers. As a first step to enhancing data interoperability for disaster risk redu... |
Design/methodology/approach |
In support of Priority 2 (“Strengthening disaster risk governance to manage disaster risk”) of the Sendai Framework and SDG17 (“Partnerships for the goals”), this paper presents a case study on barriers to data interoperability in Europe based on a series of reviews, surveys and interviews with National Sendai Focal Po... |
Findings |
For a number of European countries, there remains a clear imbalance between long-term disaster risk reduction and short-term preparation and the dominant role of emergency relief, response and recovery, pointing to the potential of investments in ex ante measures with better inclusion and exploitation of data. |
Originality/value |
Modern society is facing a digital revolution. As highlighted by the International Council of Science and the Committee on Data for Science and Technology, digital technology offers profound opportunities for science to discover unsuspected patterns and relationships in nature and society, on scales from the molecular ... |
Microwave-assisted synthesis of Cu-doped hierarchical porous carbon aerogels derived from lignin for high-performance supercapacitors |
Hierarchical porous carbon aerogels with a high specific surface area and excellent electrochemical performance were synthesized by pyrolysis and CO2 activation of Cu-doped lignin-based aerogels. The Cu-doped lignin-based aerogels were prepared by a microwave assisted sol-gel process of alkali lignin, resorcinol, and f... |
Coliphage content of sewage collected from 11 different localities in Hong Kong was determined. The number of plaque-forming units (PFU) ranged from 0.036 x 10(3) to 15.9 x 10(3) per ml. In general, urban sewage tended to be richer than rural sewage both in PFU count as well as plaque morphological variation. Seventy-s... |
A Bayesian approach is proposed for coefficient estimation in the Tobit quantile regression model. The proposed approach is based on placing a g-prior distribution depends on the quantile level on the regression coefficients. The prior is generalized by introducing a ridge parameter to address important challenges that... |
Hepatocyte growth factor (HGF) is a pleiotropic cytokine involved in tissue protection and repair in the endothelium and various organ systems. The serum concentration of this protein is markedly increased in patients with chronic renal diseases, but the clinical and pathophysiological correlates of this substance in r... |
Abstract This article surveys the evolution of the Catholic Church's official response to same-sex relations over the last two centuries. While the church has not altered its condemnation of same-sex relations, the justifications it offers for this negative judgment have shifted substantially, and they have moved, espe... |
Implementing an applicable demand response (DR) program enables the complete demand-side potentials and ensures a secure, more economic and greener operation of the power systems with the integration of renewable energy. Therefore, the present paper proposes a stochastic security-constraint scheduling approach for opti... |
Despite several attempts to introduce corresponding legislation, the EU has not yet established rules governing company groups. Given the interest of the European Commission in this topic and the assumed benefits of a European group law, this paper proposes a new concept for a legally binding European group law. This p... |
The recognition of paclitaxel's (Taxol) activity and non-cross-resistance with doxorubicin (Adriamycin) in the treatment of metastatic breast cancer has motivated study of the agent in the adjuvant setting. However, the ideal means of incorporating this new agent is not yet known. In stage IV disease, exciting results ... |
The design of a single-stage operational transconductance amplifier is presented, which uses self-cascode transistors and current shunt stages to improve its DC gain. The proposed amplifier is implemented in a standard 45 nm silicon on insulator CMOS process. Simulation results show that the amplifier has a DC gain abo... |
The Web serves as the principal mediator for information sharing and communication on a worldwide scale. Its highly decentralized nature affords a scale free growth, where each endpoint (i.e., Web site) is created and maintained independently. Web designers and developers have the onus of making sure that users can int... |
Lead (Pb) poses a potential environmental risk factor for cognitive dysfunction during early life and childhood. Resveratrol is considered a promising antioxidant with respect to the prevention of cognitive deficits and act as a potent SIRT1 agonist. Herein, this study aims to investigate the profile of neurogenesis ma... |
Tea is considered as a healthy beverage due its antioxidant properties and resultant beneficial effects on human health. India is the second largest producer of tea in the world after China, but every year Tea plants are attacked by several pests and diseases that are responsible for 7-10% loss of the crop. Tea growers... |
INTRODUCTION AND AIMS |
Despite the availability of effective treatments for substance use disorders, engaging people in treatment remains a challenge. This clinical study describes a 7-week trial of music therapy as an adjunct to group cognitive behaviour therapy with the aim of increasing patient engagement in a private hospital open group ... |
DESIGN AND METHODS |
Patient attendance rates and perceptions of the music therapy were collected at the end of each music therapy session by means of an anonymous survey, and only data from each patient's first survey were used in the analysis. Twenty-four surveys were analysed, representing feedback from 10 men and 14 women, aged between... |
RESULTS |
The average attendance rate over the 7-week trial was 75%. The results indicated that enjoyment and motivation to participate during the sessions was uniformly high (mean ratings of 4.3 and 4.0 out of 5, respectively). The majority (83%) of participants reported that they would attend another music therapy session, and... |
DISCUSSION AND CONCLUSIONS |
Music therapy is a promising approach to improving engagement in substance abuse treatment groups.Smoking as a risk factor for cortical ischaemia presumably due to carotid occlusive disease. |
Smoking is now a well established risk factor for ischaemic stroke. However, the risk associated with smoking may differ between subgroups of ischaemic stroke. To test the hypothesis that cortical ischaemia due to carotid artery occlusive disease, the latter of which has previously been linked to smoking, may have a hi... |
This article examines the extent to which undocumented status lowers wage rates among immigrants to the United States from four Mexican communities. Regression equations were estimated to determine the effect of legal status on wages independent of other demographic, social and economic variables, and special efforts w... |
Purpose Describe the incidence and characteristics of sport-related internal organ injuries due to direct contact mechanisms among high school (HS) and collegiate athletic participants from 2005/06–2014/15. Methods Data from three national sports injury surveillance systems were analysed: High School Reporting Informat... |
Oyster mushroom (Pleurotus ostreatus (Jacq. ex Fr.) P. Kumm.) is involved in the destruction of dead wood which is the main place of settlement of several living organisms. After humification, dead wood also becomes an important component of forest soils. |
The purpose of the research is to study temperature and moisture conditions of extensive cultivation of oyster mushrooms on various wood substrates. To accomplish this goal, the following tasks were set: to determine the amount of effective stress temperatures and moisture content of substrates and their influence ... |
The amount of effective temperatures necessary for the development of fruiting bodies has been determined. It was found that the intensive growth of the mushroom fruiting bodies begins after a sharp cooling (a drop in night temperatures to 4-8 ° C), which causes a stressful state of the mushroom. The amount of the ... |
To evaluate the efficacy of an educational module on evidence-based medicine (EBM) assisted with electronic medical databases (EMDs) for preclinical education, medical students (n = 111) were matriculated in a program consisted of 16 2-h sessions on EBM plus hands-on experience on EMDs in a problem-based learning-type ... |
A real device for optimal broadband signal processing is described. The device handles signals of short and long duration and operates at the real time scale. It has been manufactured with the usage of the integro-optical technology for forming the acousto-optical element. The device includes an additional chirp genera... |
Promoting the link between human and ecosystem health is crucial for building resilient communities. Hillwalking provides health benefits arising from physical activity and exposure to nature. Furthermore, it is likely to influence environmental knowledge and pro-environmental behaviour through connectedness to nature... |
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