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This paper presents a variable span multistep straightening process (VSMSP) to improve straightening accuracy and reduce the number of straightening steps for the multistep straightening of long linear guideways. It can also efficiently deal with the ineffectiveness caused by the single-step straightening process. The ... |
GRAPHICAL ABSTRACT ABSTRACT A versatile synthetic method for the preparation of 1-aminophosphonate derivatives of methylsiloxane oligomers was developed. The introduction of trimethylsilyl amino protecting groups promotes hydrosilylation. The proposed modeling technique allows entering 1-aminophosphonate fragment into ... |
In this paper, a mathematical framework is presented, helping in the identification and selection of the components that mostly affect performance in monolithic voltage regulators. A sensitivity analysis is proposed, showing how the loop transfer function depends on the values of the components used in the compensator.... |
Hepatocellular carcinoma (HCC) is a major cause of cancer-related morbidity and mortality worldwide. In the United States, HCC is the main cause of death in patients with cirrhosis, and the incidence of this malignancy is on the rise. Because HCC is associated with a particularly poor prognosis, emphasis is placed on s... |
Alternative medic al prac tic es are generally not rec ognized by the medic al c ommunity as standard or c onventional medic al approac hes. This form of medic ine inc ludes dietary supplements, herbal preparations, spec ial teas, massage therapy, magnet therapy, and spiritual healing. 1. Ac upunc ture. via www.blueher... |
The study was made of 17 patients with expected Alzheimer's disease (AD), 29 patients with Parkinson's disease (PD) and 7 with a expected dementia with Levy bodies (DLB). The severity of cognitive disorders was determined according to the following scales: Global Deterioration Rating Scale, Mini-mental State Examinatio... |
Whipple's disease is a chronic infectious disease that primarily affects the small intestine, but several organs can be involved simultaneously. The disease is caused by a gram-positive bacterium called Tropheryma whipplei. The disease is difficult to suspect because it is rare, and produces unspecific and long-term sy... |
We present the design, synthesis, and applications of a new |
class of voltage-sensitive fluorescent indicators built on a modified |
carbofluorescein scaffold. Carbofluoresceins are an attractive target for |
responsive probes because they maintain oxygen substitution patterns at the 3' |
and 6' positions, similar to fluorescein, while simultaneously possessing excitation |
and emission profiles red-shifted nearly 50 nm compared to fluorescein. |
However, the high pKa of |
carbofluorescein dyes, coupled with their tendency to cyclize to |
non-fluorescent configurations precludes their use in voltage-imaging |
applications. Here, we overcome the limitations of carbofluoresceins via |
chlorination to lower the pKa by 2 |
units to 5.2 and sulfonation to prevent cyclization to the non-absorbing form. |
To achieve this, we devise a synthetic route to halogenated sulfonated |
carbofluoresceins from readily available, inexpensive starting materials. New, |
chlorinated sulfone carbofluoresceins have low pKa values (5.2) and can be incorporated into |
phenylenevinylene molecular wire scaffolds to create carboVoltage-sensitive |
Fluorophores (carboVF dyes). The best of the new carboVF dyes, |
carboVF2.1(OMe).Cl, possesses excitation and emission profiles >560 nm, |
displays high voltage sensitivity (>30% ΔF/F per 100 mV), and can be used in |
the presence of other blue-excited fluorophores like green fluorescent protein |
(GFP). Because carboVF2.1(OMe).Cl contains a phenolic oxygen, it can be |
incorporated into fluorogenic labeling strategies. Alkylation with a sterically |
bulky cyclopropylmethyl-derived acetoxymethyl ether renders carboVF weakly |
fluorescent; we show that fluorescence can be restored by the action of porcine |
liver esterase (PLE) both in vitro |
and on the surface of living cells and neurons. Together, these results suggest |
chlorinated sulfone carbofluoresceins can be promising candidates for hybrid |
chemical-genetic voltage imaging at wavelengths beyond typical fluorescein |
excitation and emission.A report from the 13th International Conference on Alzheimer's Disease and Related Disorders (ICAD) (July 10-15, 2010-Honolulu, Hawaii, USA). |
What comes to mind when thinking of Hawaii and Honolulu are beaches, sun, sand, blue water, palm trees... But thinking and imagining may be altered in patients with cognitive impairments, and as in the brain of subjects with dementia, thunderstorms are also a reality on tropical islands. Honolulu has much more to offer... |
Some terrestrial areas have climatic and geomorphologic features that favor the preservation, and therefore, accumulation of meteorites. The Atacama Desert in Chile is among the most important of such areas, known as DCA. This desert is the driest on Earth, one of the most arid, uninhabitable localities with semiarid, ... |
The antihypertensive effect and tolerance of the combined low doses of felodipine and enalapril (5 + 5 mg daily) were compared with those of either drug at a higher dose level (10 mg daily). Our double-blind, three-way crossover study (balanced Latin square design) involved 36 elderly subjects (mean age 67 +/- 6 years)... |
Comparisons are made between direct numerical simulations (DNS) of uncontrolled and optimally noise-controlled two-dimensional mixing layers in order to identify the physical mechanism responsible for the noise reduction. The analysis is carried out in the time domain to identify events that are significant in sound ge... |
Aim: To compare the effects of 5- and 50-nm naked and PEG-coated gold nanoparticles (AuNP) on proinflammatory cytokines (IL-1β, IL-6, TNF-α) expression and histopathological changes in liver and kidneys of rats. Materials & methods: Rats were injected with different nanoparticles and sacrificed after 24 h. Results: Bot... |
By decoupling control plane and data plane, Software-Defined Networking (SDN) approach simplifies network management and speeds up network innovations. These benefits have led not only to prototypes, but also real SDN deployments. For wide-area SDN deployments, multiple controllers are often required, and the placement... |
BACKGROUND--In a previous retrospective study of tuberculosis in south London among Asian immigrants from the Indian subcontinent Hindu Asians were found to have a significantly increased risk for tuberculosis compared with Muslims. This finding has been further investigated by examining the role of socioeconomic and l... |
In 2001, President George W. Bush remarked, "Science and technology havc never been more essential to the defense of the nation and the health of the econ~my."' The responsibility for formulating science and technology policy primarily falls into the hands of Congress. However, since few members of Congress possess a b... |
The breast cancer gene, BRCA2, is essential for viability, yet patients with Fanconi anemia-D1 subtype are born alive with biallelic mutations in this gene. The hypomorphic nature of the mutations is believed to support viability, but this is not always apparent. One such mutation is IVS7+2T>G, which causes premature p... |
Bartter’s Syndrome is characterized by renal potassium wasting with hypokalemia, metabolic alkalosis, increased renin-angiotensin-aldosterone system, normal blood pressure, resistance to the pressor effects of angiotensin II and juxtaglomerular cell hyperplasia. Most of the cases have been noted in the pediatric age gr... |
In this paper, we develop a text-mining system by integrating methods from Information Extraction (IE) and Data Mining (Knowledge Discovery from Databases or KDD). By utilizing existing IE and KDD techniques, text-mining systems can be developed relatively rapidly and evaluated on existing text corpora for testing IE s... |
Janette Morgan’s ‘Greek Perspectives on the Achaemenid Empire: Persia through the Looking Glass’ is the last book published as part of the series of Edinburgh Studies in Ancient Persia. Almost twenty years after Margaret C. Miller’s ‘Athenians and Persians in the Fifth century BC: A Study in Cultural Receptivity’ was p... |
This paper presents low form factor dual polarized antenna incorporating annular ring patch geometry having 90deg phase delay element for circular polarization (CP) as well as a reactive-loaded monopole linear polarized (LP) antenna. Both types of receiving antennas operate in the same frequency region from 2.320 GHz t... |
The American Society of Electroneurodiagnostic Technologists, Inc. (ASET) presents this document to provide national criteria for evaluating the competencies needed by technologists to perform Polysomnography Studies (PSG). These national competencies were established following the analysis of survey data collected in ... |
105 Organization Sites Beacon Press www.beaconpress.org Beacon Press, a department of the Unitarian Universalist Association in Boston, has a reputation for publishing thought-provoking books that explore spiritual, philosophical, and social issues. Among these is Totem Salmon: Life Lessons from Another Species, Freema... |
Dear Editors: IN THE paper “Age-specific uncertainty of the I ingestion dose conversion factor,” the authors state that “The amount of iodine consumed in an individual’s diet has a significant influence on thyroid function and metabolism” (Harvey et al. 2003). The usefulness of this article would be enhanced if the aut... |
In the statistical steady state of forced-dissipative turbulence governed by the 2D incompressible Navier–Stokes (NS) equation, the difference between the energy flux ΠE(k) and the enstrophy flux ΠZ(k), k2ΠE(k) − ΠZ(k), where k is the wavenumber, has been proved to be negative outside the forcing wavenumber range. This... |
A "quadruple of primes" or "quadruplet" is firmly entrenched for the sets of four primes {p, p+2, p+6, p+8} OEIS A007530. By analogy, constellations of five primes {p-4, p, p+2, p+6, p+8} OEIS A022007 and {p, p+2, p+6, p+8, p+12} OEIS A022006 are named "prime quintuplets" 1 and 2. The multisets of four and five primes ... |
Abstract The righting reflex (RR) as a behavioral index of incomplete ischemia during four-vessel occlusion (4VO) remains a common exclusion criterion. In the present study different drugs (aniracetam, ondansetron, and metyrapone) were administered to Wistar rats at a variety of doses prior to unanesthetized forebrain ... |
Objective To determine the prevalence and risk factors of hypogonadotropic hypogonadism in transfusion-dependent patients with thalassemia. Patients and Methods The authors examined 29 patients with thalassemia major aged 15 years or older. Luteinizing hormone-releasing hormone tests were performed and &bgr;-thalassemi... |
Recently there has been an upsurge in interest in the use of information entropy measures for identification of similarities and differences between strings. Strings include text document languages, computer programs and biological sequences. This work deals with the use of this technique for author identification in o... |
Evidence has been provided that fat storing cells (FSC) are the major source of extracellular matrix components (ECM), if these precursor cells are activated in areas of necroinflammation to proliferate and to switch from the retinoid storing to the ECM-producing phenotype termed myofibroblast (MFB). The mechanisms of ... |
This study investigates whether and how principals implementing Instructional Leadership Teams (ILTs) were able to share decision-making authority with team members and how team members perceived this authority. Having interviewed and observed ILT members in four, in-district charter schools in a large northeastern cit... |
Background: Natural products are becoming important alternative medicines for diabetes treatment. Many Bauhinia plants in Thailand have been used in Thai traditional medicines for diabetic patients. Bauhinia plants have been reported on anti-alpha-glucosidase activity. However, Bauhinia pottsii var. pottsii G. Don whic... |
Aims To audit compliance with Scottish Intercollegiate Guidelines Network (SIGN) guideline 107: diagnosis and management of headache in adults for assessment and investigation of possible subarachnoid haemorrhage (SAH) in a 30 bedded medical assessment unit (MAU). Methods All cases presenting to the MAU in which SAH wa... |
Abstract : National cultural differences present barriers to successful coalition command and control. The challenge is compounded by distributed decision making that characterizes many operations. If U.S. military personnel are to work effectively in coalition operations, they have to understand the complexities prese... |
Introduction: Increased demand for metal free fixed partial denture in recent years led to the developing of all ceramic material with excellent mechanical properties. One of the most popular all ceramic is zirconia which shows poor bonding properties. Recently, universal primer contains of silane and phosphate monomer... |
In order to increase the computational accuracy of eddy current in rail gun by the nodal finite element method, this paper presents a global method of evaluating nodal eddy current based on the known nodal potentials, which is a Galerkin-Finite Element method formed. by employing the Schaubert-Wilton-Glisson (SWG) basi... |
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