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Although amyloidosis (Amy) is a frequent complication of chronic diseases such as tuberculosis, rheumatoid arthritis, familial Mediterranean fever and bronchiectasis (I), its occurrence in cystic fibrosis (CF) has rarely been noted, probably because of the short lifespan of CF patients. To our knowledge, only five case... |
We consider a scenario in which two legitimate transmitters attempt to communicate with a legitimate receiver over a discrete memoryless Multiple-Access Channel (MAC), while escaping detection from an adversary who observes their communication through another discrete memoryless MAC. If the MAC to the legitimate receiv... |
Environmental hazardous material polychlorinated biphenyl (PCB) exposure is associated with vascular endothelial dysfunction, which may increase the risk of cardiovascular diseases and cancer metastasis. Our previous studies illustrated the cytotoxic, antiproliferative, and genotoxic effects of a synthetic, quinone-typ... |
Micro- and nano-sized materials have received much attention regarding their biocompatibility and toxicity. To understand the influence of such materials on animals, it is very important to determine their internal distribution behavior. In this study, the biodistributions of Pt and TiO2 micro- and nano-sized particles... |
Recent studies have demonstrated that the activation of HIV-1 provirus and of the Long Terminal Repeat of HIV-1 (HIV-1-LTR) may occur upon cell-to-cell contact between peripheral blood lymphocytes (PBLs) and infected or transfected (HT29) human colonic carcinoma cells. Using transient or stable transfections, we ascert... |
Abstract Haspin is a unique protein kinase expressed predominantly in haploid male germ cells. The genomic structure of haspin (Gsg2) has revealed it to be intronless, and the entire transcription unit is in an intron of the integrin alphaE (Itgae) gene. Transcription occurs from a bidirectional promoter that also gene... |
which serves a s a representation of the protein site electronic and structural changes in a Fd /Fd electron transfer couple in the absence of%xtr&"sd,c constraints such a s might be imposed by protein structural features [2,3]. bfrksbauer, epr, magnetization and x-ray crystallographic measurements on analogues in both... |
Micro and Nano-satellites with their low thermal capacitance are vulnerable to rapid temperature fluctuations. Therefore, thermal control becomes more important, but the limitations on mass and electrical power require new approaches. Possible solutions to actively vary the heat rejection of the satellite in response t... |
BARIUM enema examination has had a very low complication rate, approximately two in 10,000 studies. During a 20-year period at the Columbia Presbyterian Hospital (New York), Seaman and Wells 1 found only 13 examples of perforation of the colon during barium enema examination. We have recently encountered a unique compl... |
Previous studies showed that chronic endotoxemia induces thickening of the alveolar wall of rabbits. The present study examines cellular changes associated with this process and attempts to define the role of PMN in this response. Rabbits received i.v. injections of either Escherichia coli lipopolysaccharide (LPS) or s... |
BACKGROUND |
Tamoxifen is widely used for treatment of estrogen receptor positive breast cancer. It is, however, associated with severe side effects of cancerous proliferation on uterus endometrium. The tumor targeting formulation strategies can effectively overcome drug side effects of tamoxifen and provide safer drug treatment. |
OBJECTIVE |
Designing tumor targeted PLGA nanoparticles of tamoxifen by attaching hyaluronic acid (HA) as ligand to actively target the CD44 receptors present at breast cancer cells surface. |
METHODS |
PLGA-PEG-HA conjugate was synthesized in the laboratory and its tamoxifen loaded nanoparticles were fabricated and characterized by FTIR, NMR, DSC, and XRD analysis. Formulation optimization was done by Box- Behnken design using Design Expert software. The formulations were evaluated for in- vitro drug release and cyto... |
RESULTS |
The particle size, PDI, and drug encapsulation efficiency of optimized nanoparticles were 294.8, 0.626, and 65.16% respectively. Optimized formulation showed 9.56 % burst release and sustained drug release for 8 h. The drug release was effected by non-fickian diffusion process supplemented further by erosion of polymer... |
CONCLUSION |
Hyaluronic acid conjugated PLGA-PEG nanoparticles of tamoxifen were designed for active targeting to breast cancerous cells. The results of MTT assay showed that tamoxifen nanoparticles formulation was more cytotoxic than tamoxifen drug alone which is attributed to their preferential uptake by cell lines by affinity of... |
For a given flow field obtained in a shock tube several visualization techniques are applied to reveal both the weak and the strong points of each individual method. Particular emphasis is put on two newly developed schlieren techniques, which prove to be most suitable for a detailed optical investigation of a large nu... |
This paper proposes a new variant of the task allocation problem, where the agents are connected in a social network and tasks arrive at the agents distributed over the network. We show that the complexity of this problem remains NP-hard. Moreover, it is not approximable within some factor. We develop an algorithm base... |
Amorphous perfluorinated polymers are of great interest for integrated optics and photonics due to their high optical transparency, low refractive index and index dispersion. Therefore, methods for accurate measuring optical parameters and thickness of light-guiding polymer films are important. We present new approach ... |
MACH—My Automated Conversation coacH—is a novel system that provides ubiquitous access to social skills training. The system includes a virtual agent that reads facial expressions, speech, and prosody and responds with verbal and nonverbal behaviors in real time. This paper presents an application of MACH in the contex... |
The setting up of a short-stay home, which offers temporary care for mentally handicapped children living with their parents in the Swedish county of Ostergötland, is described. It illustrates an approach which parents, care staff and the supervising psychologist have all found satisfactory in contrast to the provision... |
This article comes from the National Science and Technology Support Programme subject --- Argon Oxygen refining alloy application of energy saving technology, topics code 2007BAE17B01. This paper says: through integrated innovation, process reengineering and project implementation, to create liquid high-carbon chromium... |
Although the ecological importance of rhodolith (maerl, free-living coralline algae) beds is well-known, rhodolith-forming species have been neglected in molecular phylogenetic studies. This is the first molecular systematic study aimed at understanding whether the rhodolith habit is a fixed feature in lineages and det... |
BACKGROUND |
Distress tolerance (DT) has been conceptualized as a vulnerability factor for several psychopathologies. A five factor model of DT has been suggested, but its associations with anxiety and anxiety sensitivity have yet to be explored. |
OBJECTIVES |
This study aimed to further validate the five-factor model of DT, identify the associations between its factors and elevated anxiety, and assess if anxiety sensitivity mediates the association between DT and anxiety. |
DESIGN AND METHODS |
This observational study included 330 students and university workers (women = 82.7%; mean age = 27.7 years, SD = 9.4). They completed online questionnaires assessing DT, anxiety sensitivity and anxiety levels. |
RESULTS |
The five-factor model was a good fit to the data (RMSEA = .04). Two factors, and the sex of the participants, contributed to the variance in anxiety (r2 = .418, p < .001). Tolerance of negative emotion was directly (β = -1.98, 95% CI = [-2.53, -1.42]) and indirectly (β = -1.10, 95% CI = [-1.55, -.78]) associated with l... |
CONCLUSIONS |
Tolerance of negative emotion and uncertainty were associated with anxiety independently of the other factors of DT. These associations seem partially explained by the effect of anxiety sensitivity.An evaluation of SIMCA. Part 2 — classification of pyrolysis mass spectra of pseudomonas and serratia bacteria by pattern ... |
As part of a critical evaluation of the pattern recognition method SIMCA, three data sets containing pyrolysis mass spectra from bacteria were analysed using the SIMCA classifier. Each set consisted of two classes, Pseudomonas and Serratia bacteria, each class containing ten mass spectra and each mass spectrum having 2... |
» uring the fall of 1976, the high-school division of the The Adams School in New York City, a special school for learning disabled and emotionally disturbed children, implemented a teacher-designed prevocational curriculum. This program sought to provide the students with the social and academic skills that would enab... |
Background: Identifying dietary patterns that promote healthy aging has become increasingly important due to changes in food processing and consumption of processed foods. Recently, the effects of these foods and unhealthy dietary patterns on cognitive function have become more widely recognized. Aim: The aim of this r... |
Thirty-eight consecutive adult patients with myotonic dystrophy were included in a study with electrocardiography at rest and 24-hour ambulatory electrocardiography. The patients were subdivided into three groups according to the severity of the disease. The prevalence of abnormal electrocardiograms at rest was 31, 50 ... |
The molten globule state of α‐lactalbumin (αLA) has served as a paradigm for understanding the role of these partially folded states in protein folding. We previously showed that a peptide construct consisting of the A and B helices (residues 1–38) cross‐linked to the D‐ and C‐terminal 310 helices (residues 101–120) of... |
Photobiomodulation therapy (PBMT) has anti‐inflammatory, analgesic and regenerative properties. This systematic review aimed to critically appraise the published data of in vivo human randomized clinical trials (RCTs), and present a comprehensive overview of the efficacy of PBMT, as an adjunct to the nonsurgical period... |
Abstract “Prenatal/fetal programming,” implying structural/functional disorders of developing tissues/organs, consequent to an adverse intrauterine environment leading to asymmetric intrauterine growth restriction (IUGR), predisposes to metabolic syndrome and noncommunicable diseases in adulthood, in the framework of t... |
Lissajous figures, and other harmonic curves, straddle the line between physics and art. The sight of a harmonograph tracing out its curves in the Amherst College physics library in 1957 was certainly one of the things that drew young Tom Greenslade into physics and inspired a career-long appreciation of them.Large mir... |
The Advanced Virgo gravitational wave detector aims at a sensitivity ten times better than the initial LIGO and Virgo detectors. This implies very stringent requirement on the optical losses in the interferometer arm cavities. In this paper we focus on the mirrors which form the interferometer arm cavities and that req... |
This paper thus addresses two primary issues. What is the relationship between the types of electoral systems that have been used to govern initial elections in the democratizing states of Africa and the degree to wh ich party systems volatility has emerged? What other factors impact on the levels o f volatility? I exa... |
Lumbar spinal canal stenosis (LSCS) is not always correlated with spinal stenosis and severity of clinical symptoms. Although, it is important for trunk muscle function to enhance the dynamic stability of the lumbar spine, however few studies have reported on this. We hypothesized that trunk muscle function and gait a... |
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