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Prostaglandin E2 (PGE2) exerts its biological actions via EP receptors, which are divided into 4 subtypes of EP1, EP2, EP3 and EP4. In the present study, we investigated whether PGE2 regulated intercellular adhesion molecule-1 (ICAM-1) expression in human gingival fibroblasts (HGF) stimulated with tumor necrosis factor... |
High rate of dust generation and serious dust diffusion in dry directional drilling in soft and broken coal seams (SBCS) have long been critical problems in the mining process. To solve these problems, in this study, a dust hood was designed and applied to realize non-contact dust control in drilling holes. The optimal... |
The swelling and viscoelastic behaviors of samples of purified arterial elastin were investigated to develop a model for studying the viscoelastic behavior of elastin. Two osmotic stress models were used: the vapor phase model (VPM), in which the stress on the elastin sample was applied through the vapor phase by equil... |
Fluorescence spectroscopy is in many ways the ideal tool for the interrogation of complex biological systems, as it is non-invasive, sensitive, and offers high spatiotemporal resolution. For biomedical imaging luminescent probes absorbing and emitting in the red-to-near infrared (NIR) region are best suited to maximise... |
The peculiarities of pultruded FRP profiles, i.e. low mass, durability and ease of construction, make them suitable for retrofitting traditional masonry structures, particularly in seismic areas. This could represent an effective solution, not yet sufficiently explored, that allows for non-invasive and reversible inter... |
The point of my deliberately provocative title is to bring out into the open an issue which at some time or another is likely to confront any statistician associated with collaborative clinical trials or, indeed, other areas with immediate public health implications. Sometimes the issue that raises questions about the ... |
Background/Aims This article investigates the representation of black, Asian and minority ethnic staff in NHS disciplinary proceedings. Methods The study involved an in-depth knowledge review and analysis of literature on the representation of black, Asian and minority ethnic staff in NHS disciplinary proceedings from ... |
Package on Package (PoP) structures are an enabling technology for mobile devices, but they present unusual challenges in final test. Since the packaging technology is 3D, the test contactor must also take a multi-dimensional approach to the package. In final test applications a fairly standardized approach to the situ... |
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder, with an incidence of approximately 1 in 6000. It arises from a genetic abnormality involving either the TSC1 gene on chromosome 9, or the TSC2 gene on chromosome 16. The protein product of the TSC1 gene is hamartin and that of TSC2 is tuberin. In cells... |
Several inhibitors of ethylene synthesis or action were tested to determine their effects on fruit set of apple (Malus domestica Borkh.)9 sour cherry (Prunus cerasus L.) and plum (P. domestica L). None increased set of cherry or plum and only aminoethoxyvinylglycine (AVG) increased set of apple. This compound reduced s... |
The internet and world wide web make it easier for professionals, patients and carers to access medical expertise and technology. Websites providing information about geriatric medicine and gerontology include those of general and specialized journals and textbooks--including publications on geriatric psychiatry, geria... |
In this paper we study integral equations of the form x(t) = a(t) R t 0 C(t,s)x(s)ds with sharply contrasting kernels typ- ified by C � (t,s) = ln(e + (t s)) and D � (t,s) = (1 + (t s)) 1 . The kernel assigns a weight to x(s) and these kernels have exactly opposite effects of weighting. Each type is well represented in... |
The time lag between data collection and management implementation is a source of uncertainty and bias in the calculation of acceptable biological catch. Here, we developed a method to use small-scale survey data for juvenile Japanese pufferfish (Takifugu rubripes) to shorten this time lag and achieve accurate short-te... |
Abstract Objective: Hospice volunteers often encounter questions related to spirituality. It is unknown whether spiritual care receives a corresponding level of attention in their training. Our survey investigated the current practice of spiritual care training in Germany. Method: An online survey sent to 1,332 hospice... |
Montane red spruce (Picea rubens Sarg.) in the northeastern United States has undergone a decline during the past two decades. One symptom associated with the decline syndrome is the episodic browning of first-year foliage in early spring. To examine the potential role of winter desiccation in this browning, the water ... |
The imbalance of generation and load demand leads to frequency deviation, and this problem may become more serious when intermittent wind power employed in grids. In recent years, the number of electric vehicles connected to power grids has increased rapidly. Electric Vehicles (EVs) can be used as distributed energy st... |
As the quarantine life from COVID-19 is prolonged, the number of people suffering from mental and psychological disorders such as fear, anxiety, and depression from viral infection is increasing Healing agriculture, which mediates agricultural resources, has proven various effects in terms of psychological and emotiona... |
UNLABELLED |
The aim of this study was to compare the visual analysis of attenuation-corrected and noncorrected 18F-fluoro-2-deoxy-D-glucose (FDG) PET images in patients with primary or metastatic breast cancer using standardized film documentation and to evaluate the influence of attenuation correction on lesion detectability. |
METHODS |
Standard FDG PET of the breasts and of the axillary regions was performed on 28 women with breast cancer. Transmission scans were acquired for attenuation correction after administration of FDG. Transverse and coronal slices and maximum intensity projections both with and without attenuation correction were documented ... |
RESULTS |
One hundred eighty-four of 189 lesions in 28 of 28 patients were found on attenuation-corrected and noncorrected images. Seventeen lesions were found in the breasts of 12 patients. In 18 patients, 31 axillary lesions were found. Moreover, 141 lesions representing distant metastases were detected in 18 patients. Attenua... |
CONCLUSION |
Attenuation correction by transmission measurement after injection may impair lesion detectability in PET for staging of breast cancer patients. When using the image modalities described, noncorrected PET images should be considered in image analysis.Quantitative analysis of Miocene to Recent forearc basin evolution al... |
The Colombian accretionary complex forms the active convergent margin of the North Andes block of South America beneath which the east Panama Basin of the Nazca plate is subducted at a rate of 50–64 km Myr−1. Multichannel seismic reflection data, collected as part of RRS Charles Darwin cruise CD40, image a series of we... |
‘Culture’ has been described as ‘one of the. . . most complicated words in the English language’. Chosen by Merriam-Webster as their ‘word of the year’ for 2014, it may also be a confusing concept. Whether complicated, confusing or both, ‘culture’ is increasingly used within medical education to denote differences or c... |
NOAA plans to build a Geostationary Lightning Mapper (GLM) whose objectives are providing continuous, full-disk lightning measurements for storm warning and science applications. Due to limited telemetry bandwidth, much of the detection processing will be done autonomously. Since the contractor is responsible for the a... |
The main objective of this study was to examine whether including publicly available American Society of Anesthesiologists (ASA)–approved examples for the ASA Physical Status classification system improves correct assignment both by non– anesthesia-trained and anesthesia-trained clinicians. A total of 10 hypothetical c... |
This paper reviews the relationship between specific power system operations and market functions, introduces a definition of market conditions that correspond to grid operating states, and proposes an integrated approach for real-time power market operations and monitoring, which will help ensure reliable operations a... |
Many patients with chronic urticaria (CU) worry that foods or other allergens are responsible for their urticaria. Skin prick testing (SPT) may be one of the investigations used to provide a clear illustration. The purpose of our study was to assess the prevalence of positivity of SPT to food allergens and aeroallergen... |
Aspects of membrane stucture and functions were studied in ethidium bromide resistant cells. Submitochondrial particles were solubilized and electrophoresed. The gel patterns, representing mitochondiral membrane proteins, demonstrated qualitative and quantitative alterations in mitochondrial preparations derived from v... |
A compact filtering liquid dielectric resonator antenna (FDRA) with polarization reconfigurable is proposed. The DRA is fed by a microstrip line and a vertical metal strip, excited in fundamental $TE_{1\delta 1}^{y}$ DRA mode. By designing two stubs of different lengths on the microstrip line, two cross-coupled feed st... |
Anaphylaxis is an acute, severe, hypersensitivity reaction that can lead to asphyxia, cardiovascular collapse and cardiac arrest. This reaction is sudden, severe, and involves the whole body. Common causes include foods such as nuts, shellfish, dairy products and eggs. Non-food causes include bee/wasp stings, latex and... |
Voltage Source Converter based High Voltage Direct Current (VSC-HVDC) transmission system is an important equipment for building smart power grid, as well as an important support for offshore wind power, isolated island power supply and grid integration of photovoltaic power generation. As a key equipment in VSC-HVDC, ... |
IL-10 is a pleiotropic cytokine with multifaceted functions in establishing immune homeostasis. Although expressed by Th1 and Th2 cells, conventional Th1 cells produce marginal levels of IL-10 compared with their Th2 counterparts. In this study, we investigated the epigenetic mechanisms of Il-10 gene expression in Th1 ... |
Background: The study is located in Istanbul, Turkey, where more than 750,000 Syrian refugees reside, largely in urban settings. It develops and pilot tests a novel model for helping urban refugee families in settings with limited to no access to evidence-based mental health services for refugees, by delivering a tran... |
BACKGROUND |
Calcium channel blockers (CCB) of all subclasses: the dihydropyridines, benzothiazepines, and phenylalkylamines, at nanomolar concentrations, have been shown to up-regulate interleukin-6 (IL-6) mRNA. We investigated the underlying molecular mechanism responsible for IL-6 induction in response to the CCB amlodipine, dil... |
METHODS AND RESULTS |
All 3 CCB directly activated transcription of the human IL-6 gene in primary human VSMC in a time- and dose-dependent manner, as demonstrated by luciferase reporter gene assays using a 651-bp fragment of the human IL-6 gene promoter. Deletion analysis of the IL-6 promoter revealed that CCB inducible promoter activity w... |
CONCLUSIONS |
The results demonstrate that CCB of all 3 subclasses are capable of activating NF-IL6 and NF-kappaB. CCB may thus directly regulate cellular functions by affecting the activity of transcription factors independent of changes of intracellular calcium concentrations, an observation that is of interest considering the bio... |
Social work educators are in a good position to encourage the uptake of evidence-based practice more widely throughout the profession. Despite increasing attention being paid to it within professional literature, it seems to be making inroads to practice only very slowly. This article interprets that slow uptake as a f... |
Mammalian hibernators prepare for the winter by depositing fat in existing fat cells. There is little, if any, production of new fat cells. This is curious because equivalent fat deposition in rats is associated with substantial fat cell production. To determine whether degree of weight gain, diet composition, or some ... |
In this study the effects of horizontal bin locations in an order picking workstation on upper arm elevation, trunk inclination and hand use were investigated. Eight subjects moved (self-paced) light or heavy products (0.2 and 3.0 kg) from a central product bin to an inner or outer order bin (at 60 or 150 cm) on the le... |
A 32-year-old gentleman underwent a laparoscopic wedge resection of the stomach for gastrointestinal stromal tumor, with subsequent anastomotic dehiscence treated with urgent surgical revision. Following acute abdominal pain and severe sepsis, the patient was directly referred for a total gastrectomy with esophago-jeju... |
Abstract The paper discusses issues related to the optimisation of magnetic couplings used in bioreactors (manufactured by JSC “Biotehniskais Centrs”). The purpose of optimisation was to preserve the maximum breakaway torque of the magnetic coupling while reducing the mass of rare earth elements used in its structure. ... |
Summary. School effectiveness analyses have largely ignored the role of the family as an important source of variation for children's educational progress. Sibling analyses in developmental psychology and behavioural genetics have largely ignored sources of shared environmental variation beyond the immediate family. W... |
Butterflies are insects that must be preserved because of their role in balancing ecosystems. The purpose of this study is to know the diversity of butterflies in Mount Bromo FSAP. This research was conducted in May-August 2019. The observation site consisted of four stations, i.e. heterogeneous forest, cultivation fie... |
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