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Macrophages play an essential role in the early immune response against Toxoplasma and are the cell type preferentially infected by the parasite in vivo. Interferon gamma (IFNγ) elicits a variety of anti-Toxoplasma activities in macrophages. Using a genome-wide CRISPR screen we identified ∼130 Toxoplasma genes that det... |
We studied the magnetic field dependence of a charge-frustrated state formed in a triangular triple quantum dot. Stability diagrams at various magnetic fields were measured by using two-terminal and three-terminal conductance measurement schemes. We found that the frustrated state broke down at an external magnetic fie... |
Edible and non-edible oils are used for the production of biodiesel from the last so many years and these oils are extracted from their respective seeds. Jatropha oil is used as a feedstock to produce biodiesel for running the Compression Ignition engine. A statistical model is developed to interrelate the trans-esteri... |
Assessing individual change is an important topic in both psychological and educational measurement. An adaptive measurement of change (AMC) method had previously been shown to exhibit greater efficiency in detecting change than conventional nonadaptive methods. However, little work had been done to compare different p... |
The number of queued bicycles on a signalised link is crucial information for the adoption of intelligent transport systems, aiming at a better management of cyclists in cities. An unsupervised machine learning methodology is deployed to produce estimations of accumulation levels based on data retrieved from a bicycle ... |
Endostatin, a C-terminal fragment of collagen XVIII, is a promising protein drug which is in development for cancer therapy due to its anti-angiogenic activity. Although several endogenous molecular forms of human endostatin differing in their N-terminal length and their post-translational modifications (18.5-22 kDa) h... |
The aims of the present study were (1) to analyze the separate effects on plaque, caries, and gingivitis of several measures (oral hygiene instruction, professional tooth cleaning with mechanical instruments, topical application of sodium monofluorophosphate - MFP) which have been incorporated in a prophylactic treatme... |
Introduction Faecal calprotectin (FC) has recently become widely used to differentiate between IBS and IBD following NICE diagnostic guidelines (DG11). There are a number of different assays in use throughout the UK using different extraction methods. We have evaluated a newly introduced Quanta-Lite FC assay (Werfen Lt... |
This study is concerned with the realization of Brown’s theory of assessing reading on the English national examination. This study focused on the English national examination for junior high schools in the academic year 2018/2019. It aimed to know what types of assessing reading were used and what the most dominant ty... |
The molecular processes leading to formation of nanoparticles of blue haze over forested areas are highly complex and not fully understood. We show that the interaction between biogenic organic acids and sulfuric acid enhances nucleation and initial growth of those nanoparticles. With one cis-pinonic acid and three to ... |
ZnO nanowires, CuO nanowires, and alpha-Fe(2)O(3) nanotubes as well as their corresponding arrays have been successfully synthesized via a low cost, generalizable, and simplistic template method. Diameters of one-dimensional (1-D) metal oxide nanostructures ( approximately 60-260 nm), measuring micrometers in length, c... |
Objective: The study was to evaluate the diagnostic efficacy of nested polymerase chain reaction (nPCR) using primers targeting B1 gene of Toxoplasma gondii (T. gondii) with Witmer Desmonts coefficient (WDC) technique in intraocular fluids of clinically suspected toxoplasma retino choroiditis (TRC) patients. Materials ... |
Three hundred and twenty nine strains of non-penicillinase-producing Neisseria gonorrhoeae (non-PPNG) isolated from men and women were tested for their susceptibility to a range of antibiotics, and were also auxotyped and serogrouped. Nearly 6% (18) of 312 strains tested were resistant to 1 mg/l or more penicillin (com... |
Background: In this work, support vector regression (SVR) was applied to the optimization of extended release from swellable hydrophilic pentoxifylline matrix-tablets and compared to multiple linear regression (MLR). Methods: Binary mixtures comprising ethylcellulose and sodium alginate were used as the matrix-former. ... |
Nurses are being urged by Public Health England (PHE) to ‘pledge’ to fight one of the biggest threats to public health – antibiotic resistance. To mark European Antibiotic Awareness Day on November 18 and World Antibiotic Awareness Week, which ran from November 16 to 22, PHE called on nurses to become antibiotic guardi... |
This paper presents the results of time and frcq-cxency dissemin:ltion research at Interstate Electronics that achieves 10-nanosecond timing accuracy and stability of parts in loi4 over continental baselines. Global Pot;itionirrg Syate~rl (GPS) receiver data is processed by a differe~ltial, coxnmon--view techxique that... |
This paper reports an educational program experience for nurses on caring for the family, at the hospital environment. The objective was to train nurses for the care of the family. The strategies adopted for teaching/learning focused on the Calgary Model of Assessment and Family Intervention, with a group of nurses fro... |
MicroRNAs (miRNAs) were reported to be involved in the development of clear cell renal cell carcinoma (ccRCC). However, the study on miRNAs in ccRCC is far from complete. The present study identified miRNAs which could act as potential novel prognostic markers for ccRCC, and analyzed its possible mechanism. We found th... |
INTRODUCTION |
Earlier studies reported serotonergic activity for cimicifugic acids (CA) isolated from Cimicifuga racemosa. The discovery of strongly basic alkaloids, cimipronidines, from the active extract partition and evaluation of previously employed work-up procedures has led to the hypothesis of strong acid/base association in ... |
OBJECTIVE |
Re-isolation of the CAs was desired to permit further detailed studies. Based on the acid/base association hypothesis, a new separation scheme of the active partition was required, which separates acids from associated bases. |
METHODOLOGY |
A new 5-HT(7) bioassay guided work-up procedure was developed that concentrates activity into one partition. The latter was subjected to a new two-step centrifugal partitioning chromatography (CPC) method, which applies pH zone refinement gradient (pHZR CPC) to dissociate the acid/base complexes. The resulting CA fract... |
RESULTS |
A new CA was characterised. While none of the pure CAs was active, the serotonergic activity was concentrated in a single pHZR CPC fraction, which was subsequently shown to contain low levels of the potent 5-HT(7) ligand, N(omega)-methylserotonin. |
CONCLUSION |
This study shows that CAs are not responsible for serotonergic activity in black cohosh. New phytochemical methodology (pHZR CPC) and a sensitive dereplication method (LC-MS) led to the identification of N(omega)-methylserotonin as serotonergic active principle.Factor Analysis and Cooling Technology Study on the Therma... |
Deep mining will definitely cause high temperature mining face. This paper induces the primary and secondary importance of different factors that affect the thermal environment of high temperature working face by field data analysis and heat transmission mechanism analysis. It also shows the technical economical compar... |
Research is unclear about when expressing negative emotions to children performs valuable socialization and regulatory functions and when, instead, it undermines children’s adjustment. In this study, we isolated 1 kind of negative expression to test the aversion sensitivity hypothesis: that rapid increases in mothers’ ... |
In Palestine, antibody screening is done antenatally only for pregnant women who are Rh-D negative. However, we report the first hemolytic disease of the newborn (HDN) due to anti-e in Palestine, illustrating the importance of alloantibodies other than anti-D as a cause of HDN. A pregnant woman had e-antigen negative a... |
High fluid pressures can be present throughout the effective joint space after total hip replacement and can extend locally to the bone implant interface. A new experimental implant model was developed to study whether local fluid pressure can induce osteolysis at a bone implant interface. Twelve mature rabbits receive... |
Anton Yasnitsky is a Social Sciences and Humanities Research Council (SSHRC) of Canada postdoctoral fellow at York University and a research associate at the University of Toronto. Elena F. Ivanova is a Doctor of Psychological Sciences, professor at Karazin National University, Kharkov, and head of the Department of Ge... |
The molecular mechanism of the action of lithium salts in the treatment of bipolar disorder is not well understood. As their therapeutic action requires chronic treatment, adaptive neuronal processes are suggested to be involved. The molecular basis of this are changes in gene expression regulated by transcription fact... |
As the primary active substance in tobacco, nicotine affects the activity of the central nervous system, and its effects are sex-dependent. There are complex interactions between the gut and brain, and the gut microbiome can influence neuronal activity and host behavior, with diverse chemical signaling being involved. ... |
Patient-centric healthcare is an emerging healthcare model that optimizes the healthcare system to focus on patient experience and outcomes for better health and well-being. It requires that patients as well as physicians should have the ability to obtain and understand health information, and make appropriate health d... |
Online discussions have been around for a quarter of a century (USENET) and have recently become more popular and ubiquitous thanks to newsgroup archives (e.g. GoogleTM Groups) and the availability of web interfaces. E-learning initiatives (e.g. Ikarus 2004 Online Seminar) invariably include discussion components, due ... |
This new 5-page publication is the fifth in the Conducting the Needs Assessment series. The preassessment phase, also known as the exploration phase, of conducting a needs assessment includes defining the purpose, identifying existing information, and determining the appropriate methods to conducting the needs assessme... |
Control system developed for hybrid wind diesel system (HWDS) based microgrid is presented. The hybrid system consists of six double fed induction generator (DFIG) based wind turbine generation system, a diesel generation system with synchronous machine and electrical power grid supply. Control system developed for bot... |
The article considers the substantial features of motivational-volitional aspects of professional risks. Explains the concept of a situation of uncertainty, discusses the factors deforming perception of risk and the motives that determine the activity of the teacher, directed on overcoming the uncertainty. It is underl... |
Salicylate, one of the most widely used drugs, is known to induce reversible tinnitus and hearing loss. Salicylate interferes with outer hair cells (OHCs), which are believed to underlie normal auditory frequency selectivity and sensitivity. In the present experiments, the effects of salicylate and lanthanides on OHC m... |
Eleven cases of multicystic dysplastic kidney (MCDK) in children were diagnosed over an 11 year period. All underwent postnatal ultrasound (US) studies. Four different patterns of MCDK were recognized: (1) Six cases presented with the classic sonogram of multicystic components. (2) Three cases had hydronephrotic form; ... |
The efficient operation of fuel cells in the lower power range requires an adaptation of the individual auxiliary components like pumps, compressors and converters. Within the scope of this paper, the models of the single components and of the fuel cell are derived from real behavior and are combined in an efficiency c... |
Objectives: High-risk human papilloma virus (HPV) infection is associated with carcinogenesis in oropharyngeal squamous carcinoma (OSCC), and patients with HPV (+) tumors have significantly favorable prognosis. However, the reason for this good clinical outcome has not been revealed. Epithelial-mesenchymal transition (... |
Stimulated photoluminescence (PL) emission has been observed from an oxide structure of silicon when optically excited by a radiation of 514nm laser. Sharp twin peaks at 694 and 692nm are dominated by stimulated emission, which can be demonstrated by its threshold behaviour and linear transition of emission intensity a... |
Red blood cells of several mammalian species (e.g., human, rabbit, bovine) possess a countertransport system for Li and Na. We have used rabbit red blood cells to determine the extent of sodium-proton exchange by this countertransporter. Ouabain-insensitive 22Na efflux into phosphate-buffered K-acetate media of varying... |
Ca2+/calmodulin-dependent kinase II (CaMKII) is a key mediator of long-term potentiation (LTP). Whereas acute intracellular injection of catalytically active CaMKII fragments saturates LTP (Lledo et al., 1995), an autonomously active form (T286D) of CaMKII holoenzyme expressed in transgenic mice did not saturate potent... |
Immunolocalization of glutathione-peroxidase (GSH-PO), apoptosis and bcl-2 protein in the rat ventral prostate was investigated in the presence or absence of androgen. Male Sprague-Dawley rats were divided into four experimental groups. Group 1 consisted of intact controls. In group 2, rats were sacrificed two days aft... |
An X-ray diffraction technique was used to measure the residual stress in the surface of a specimen containing a coating of a NijAl intermetallic compound produced bythe SHS (Self-propagation High temperature Synthesis) method. The Ni3Al was using the coating material for spherical carbon cast iron substrate and austen... |
This paper presents an analysis of some novel approaches for visual information retrieval (VIR) system design which are based on extraction of wavelet coefficients and applying specific similarity metrics. Four families of wavelets and three techniques for computing similarity between queried and retrieved images have ... |
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