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We have developed a new precursor, 3,17β-O-bis(methoxymethyl)-16β-O-p-nitrobenzenesulfonylestriol (14c) of 16α-[(18) F]fluoroestradiol ([(18) F]FES). Although we could not selectively protect the C17 alcohol in the presence of the C16 alcohol, we were able to prepare and chromatographically isolate the desired C16 TBDM... |
Tissue acquisition under endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is important in obtaining a pathological diagnosis in certain malignant and benign diseases. These include well-differentiated adenocarcinomas, autoimmune pancreatitis, and sarcoidosis. Tissue specimens also allow for additional immu... |
This paper describes the development and validation of a simple reverse phase ultra performance liquid chromatography (RP-UPLC) method for the quantitative determination of 2-(4',4'-Dibromomethylphenyl)benzonitrile impurity content at low level in Irbesartan drug substance. Separation was achieved with 100mm x 2.1mm, 1... |
The patency of 50 cm long, 1.7 mm ID heparin-polyvinyl alcohol (PVA) coated SBS arterio-venous shunts in pigs at shear rates greater than 1000 s-1 was found to be not different from that of identical shunts coated with PVA but without heparin. This was attributed to the absence of any measureable effect of surface boun... |
ONE DAY IN LATE MARCH 1697, a ship named the Adventure Galley arrived at the Island of Mohilla, one of the Comoro Islands. Its fever-stricken crew careened the vessel for cleaning and then proceeded to die off one by one, fifty men dead in about a week. The Adventure Galley had come to the Comoros the previous month, a... |
We describe the successful treatment of a pediatric transplant patient with simultaneous intermittent hemodialysis and therapeutic plasma exchange (TPE). The patient presented with kidney graft failure. He had life threatening electrolyte disturbances and fluid overload due to antibody‐mediated rejection. Therefore, he... |
In [1] , the Acknowledgement section should have read as follows. The tests were partially conducted at the Center for Mobile Propulsion (CMP), RWTH Aachen University. The authors would like to thank DENSO Automotive Deutschland GmbH, IPG Automotive GmbH, and dSPACE GmbH for the supply of hardware and software. For the... |
Virtual citizen science (VCS) uses computer-mediated interaction (usually a Web-based platform) to enable the public to work with professional scientists conducting research. However, there is currently a lack of research about the core features of VCS projects. This would aid professional scientists in engaging in bes... |
This thesis is devoted to a bottom-Up approachfor the management of network security policies fromhigh abstraction level with low cost and high confidence.We show that the Network Role Based Access Control(Net-RBAC) model is adapted to the specification ofnetwork access control policies. We propose policymining, a bott... |
The U.S. fertility rate began a marked decline in 1971. The effect of legal abortions and of increased federal subsidy for family planning services on this decline is evaluated. Both took place several years before the decline. Of all legal abortions performed in 1970 78% were for women under age 30. Of patients seekin... |
Notwithstanding recent interest in the study of constitutional amendment rules, there is very limited scholarship investigating the structure of formal amendment framework and little doctrinal debate on the role of upper houses, as sub-national units’ representatives, played in national amendment process and their capa... |
This article develops new insights into the gendered insecurities of the neoliberal state in Latin America by exploring the militarization of public security in Rio de Janeiro during 2003—08 around campaigns to stop the ‘trafficking’ of sex workers. Findings illuminate the intersection of three neoliberal governance lo... |
The paper analyzes how the self-regulatory institutions of two legal professions – |
attorneys-at-law and in-house lawyers – developed in Poland and Russia from the second half |
of the 19th century until the collapse of state socialism at the beginning of the |
1990s. These two countries constitute the most contrasting cases of socialist |
transformation in the region in terms of legal traditions and of the broader |
socio-political context. To adequately grasp the case differences it is necessary to |
include the formative period of the modern legal profession in the region. The comparative |
analysis uses the conceptual framework of the sociology of professions. It shows that (1) |
attorneys-at-law were able to preserve a certain degree of collective autonomy and |
self-regulation during most of the time; (2) institutional path dependencies reaching back |
into the pre-socialist past determine the degree of autonomy and self-regulation; (3) the |
discrepancy between both countries is particularly pronounced in the case of the |
occupational group of in-house lawyers; (4) the state-socialist regimes were, |
therefore, not as unifying and homogenizing as it is sometimes assumed.[Research on Rho-kinase expression in pulmonary arterioles of rat exposed to hypoxia]. |
OBJECTIVE |
To evaluate the expression and the role of Rho-kinase (ROCK I and ROCK II )in the development of hypoxic pulmonary hypertension of rat. |
METHODS |
Thirty six of adult male SD rats were randomly divided into six groups; one group was exposed to air as normal control, the other five groups were exposed to isobaric hypoxia for 1 day, 3 days, 1 week, 2 weeks and 3 weeks respectively. Microtube method was used to measure the mean pulmonary arterial pressure (mPAP). Th... |
RESULTS |
The mPAP and RV/(LV+S) values increased with time prolongation of rats exposed to hypoxia (P<0.05). The ratio of arteriole wall thickness/vascular external diameter(WT%) and vascular area/total vascular area(WA%) went forward to a height with exposing rats to hypoxia for a long time; WT% and WA% of hypoxia group rats e... |
CONCLUSIONS |
Hypoxia led Rho-kinase and Rho-kinase mRNA to have an increased expression. Rho-kinase may play a role in the development of hypoxic pulmonary hypertension by contracting and remodeling pulmonary arterioles.Synergistic increase in cardiovascular risk in diabetes mellitus with nonalcoholic fatty liver disease: a meta-an... |
Background Nonalcoholic fatty liver disease (NAFLD) has been linked to an increased risk of cardiovascular disease (CVD). To explore the impact of diabetes mellitus (DM) as a cardiovascular risk factor, this meta-analysis quantitatively assessed the association of NAFLD and CVD in diabetic patients. Methods PubMed, EMB... |
Biomembranes composed of lipids and proteins play central roles in physiological processes, and the precise balance between different lipid species is crucial for maintaining membrane function. One pathway for the biosynthesis of the abundant lipid phosphatidylcholine in eukaryotes involves a membrane-integrated phosph... |
ASCA observed a new X-ray pulsar recently discovered with RXTE in the Small Magellanic Cloud, and detected coherent pulsations with a barycentric period of 2.37230± 0.00004 s. The position is determined within a ∼ 30′′ radius error, which is much more accurate than that reported with RXTE. Since the position error well... |
Some advantages of predicting reliability include providing advance warning signs of failure, and the reduction of life cycle costs by reducing inspection and unscheduled maintenance. However, predictions can be inaccurate if they do not account for the actual environments that the product is subjected to in its li8fe ... |
Recent experimental examination of the thermoelectric properties of the half Heusler compound PtYSb has revealed that PtYSb has a relatively high thermoelectric figure of merit (ZT) of 0.2 at around room temperature. However, the thermoelectric properties have been examined only in the low-temperature region, and no hi... |
Cognitive sharing of objects is fundamental in a heterogeneous robot system composed of a Unmanned Aerial Vehicle and a ground robot. Since the viewpoint of UAV is greatly different from ground robot, they may have different perceptions about the same objects. That makes it difficult to realize cognitive sharing. In th... |
Background: The home care setting is ideal for medical students to learn about the importance of interprofessional collaboration in the community. Aims: This project examined the impact of a unique program designed to facilitate medical students’ knowledge and awareness of the challenges of interprofessional care in th... |
Introduction While radiofrequency ablation has revolutionized the management of tachyarrhythmias, the rate of arrhythmia recurrence is a large drawback. Successful substrate identification is paramount to abolishing arrhythmia and bipolar voltage electrogram's narrow field of view can be further reduced for increased s... |
The lands bordering the Gulf of Mexico attracted the attention of Claude (1644-1720) and Guillaume (1675-1726) Delisle around 1700, after the voyagesof Robert Cavelier de La Salleand at the time when the French began to establish themselves in the lower Mississippi valley.This had international consequences, for the Sp... |
O processo de ocupacao do Sul do Brasil foi resultado das diferentes investidas realizadas no seculo XVII (jesuitas espanhois, Coroa portuguesa, bandeirantes e vicentistas), no seculo XVIII (acorianos) e no seculo XIX (outros imigrantes europeus). Em todas essas etapas, emergiram atividades economicas como as estâncias... |
Abstract Objectives: To analyze intraepidermal nerve fiber density (IEFND) by skin biopsy, evaluate the effect of age, anatomical sites, and ethnic origin on IEFND and develop a reference range of IENFD at the distal leg of healthy human. Methods: Seventy skin biopsy specimens from surgical procedures involving 70 pati... |
Due to their potential degree of complexity, up-and downward scalable operating systems make connguration support reasonable, at least in a semi-automated style. If the need for dynamically adaptable family members is given, system support for applying connguration decisions at runtime is a must. But is the pure circum... |
A 30-year-old man presented with recurrent hematomas and tingling in his left leg, caused by a large femoral neck osteochondroma that induced multiple muscle ruptures and compressed the ischiadic nerve. There were no radiological signs of malignant transformation and symptoms disappeared without intervention. Hence, we... |
Harmonic terminating impedances have been shown to drastically effect the performance of RF/microwave frequency multipliers. In the literature, various apparently differing conclusions have been obtained on the proper terminating impedances for active multipliers to achieve optimum performance. This paper presents a ri... |
Abstract This article examines the comprehensiveness of the University of South Africa (UNISA) as an Open Distance Learning (ODL) institution and the challenges faced by experimental disciplines within ODL. Those challenges are brought about by the attempt to harmonize study and research programs in the College of Scie... |
In this paper a fractal technique is used to design the rectangular microstrip patch antenna for multiband wireless applications. FR4 glass epoxy material is used as a substrate material with thickness of 1.6mm and dielectric constant 4.4. The main purpose of this paper is to analyze the effect of introducing the fract... |
CONTEXT |
Exhaustive exercises may become detrimental, causing disturbance of intracellular oxidant-antioxidant balance and damage to macromolecules, leading to genomic instability when DNA/chromosomes get damaged. As these are precancerous lesions, cancer occurrence is probable. Because professional sports requires high-intensi... |
AIM |
To evaluate genetic damage at DNA and chromosomal levels in hockey and baseball-soft ball players and compare with levels in age- and sex-matched sedentary controls. |
SETTING AND DESIGN |
Players professionally active in their sport from 3 to 11 years on a daily training session of 4h/day were contacted during their camps, and the study was approved by the Institutional Ethics Committee. All participants were healthy individuals, not on any medication and were not taking any supplements. |
MATERIALS AND METHODS |
Genetic damage using the single cell gel electrophoresis assay and buccal micronucleus cytome assay of 56 individuals (36 players and 20 controls) was evaluated. |
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