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Brown adipose tissue (BAT) is an energy-expending organ that produces heat. Expansion or activation of BAT prevents obesity and diabetes. Chronic cold exposure enhances thermogenesis in BAT through uncoupling protein 1 (UCP1) activation triggered via a β-adrenergic pathway. Here, we report that the cold-sensing transie... |
Common superficial oral lesions include candidiasis, recurrent herpes labialis, recurrent aphthous stomatitis, erythema migrans, hairy tongue, and lichen planus. Recognition and diagnosis require taking a thorough history and performing a complete oral examination. Knowledge of clinical characteristics such as size, lo... |
at present the non-contact stress sensor which can be choose are not many, so it is necessary to develop the new non-contact stress sensor. A new kind of the non-contact stress sensor based on magnetoelastic effect with three magnetic poles is designed in this paper. The author first discussed the structure and the ope... |
Cells employ macroautophagy to deliver aggregates of misfolded and/or ubiquitinated proteins for lysosomal degradation or supply of essential macromolecules under conditions of nutrient deprivation. The former seems complementary to the proteasome system, which is likely to degrade only soluble proteins. While bulk deg... |
Recently the new graphitic material, BC 3, has been shown to exhibit electrical conductance which is 10% larger than graphite. In order to explain this behavior we show that in the BC 3 monolayer the Fermi level lies at the top of the o bands and that the semimetallic behavior, which appears upon stacking of the semico... |
Thanks to ACE 2 umbrella, measurement cooperation between IETR and TKK-MilliLab has been established and thus enabling characterization of a half Maxwell Fish Eye lens at 150 GHz. Results at 110 GHz provide comparison between IETR and TKK-MilliLab antenna test facilities. The agreement between the results is very good.... |
A new tracking control system by mountain climbing method using playback RF signal was developed. In order to use the system without any conventional method, speed compensation control and dynamic mode control were developed. And a new detecting method of rotational phase for cylinder that also uses playback signal was... |
Summary of studies is presented towards minimization of beam loss in the critical locations at the Fermilab Tevatron to reduce background rates in the collider detectors and to protect machine components. Based on detailed MonteCarlo simulations, measures have been proposed and incorporated in the machine to reduce acc... |
In this paper, we propose the employment of a combination of multi-document summarization[2] and automated layout[3] as a post-processing step in document retrieval. We examine the use of an interactive textual fisheye that employs automated layout techniques to present a generated natural language summary as a replace... |
Abstract Phlebotomus papatasi (Scopoli) (Diptera: Psychodidae) is the main vector of Leishmania major Yakimoff & Schokhor; which is the cause of self‐limiting cutaneous leishmaniasis in the Old World. This sandfly is found in houses, animal shelters, caves and rodent burrows. It has a large geographical range, which in... |
Abstract In this work, a series of unconfined compression tests at different water contents were performed to investigate the mechanical behaviour of clay–sand mixtures compacted in standard Proctor conditions. For studying the effect of water content and suction on unconfined compressive strength (UCS) and on strain s... |
Distributional word vectors have become an indispensable component of most state-of-art NLP models. As a major artefact of the underlying distributional hypothesis, distributional word vector spaces conflate various paradigmatic and syntagmatic lexico-semantic relations. For example, relations such as synonymy/similari... |
Interference with protein interactions may be the mechanism of the anti-inflammatory and antiproliferative activity of dual-function ERK5 inhibitors. Among the mitogen-activated protein kinases (MAPKs), extracellular signal regulated kinase 5 (ERK5) is unique in having a large noncatalytic C-terminal domain in addition... |
A simple constitutive model for temperature dependent behavior of ferroelectric materials is developed. This model is based on the one-dimensional phase transformation model of shape memory alloys. To model the temperature dependent behavior of the ferroelectric materials, a paraelectric phase is considered in addition... |
During the past five years, a widespread resurgence of popular feminism has taken place in Germany. This essay places the emergence of “popfeminism,” a specifically German variant of contemporary feminism, within the context of the socioeconomic developments, generational contests, and feminist history that have inform... |
Work in progress toward the creation of a "cultured neuron probe" is described. This is a silicon structure similar to that for a multielectrode probe, but with embedded neurons which are intended to grow out and integrate with the neurons of a host nervous system into which the probe has been inserted. Each probe neur... |
Molecular transport measurements through isolated nanopores can greatly inform our understanding of how such systems can select for molecular size and shape. In this work, we present a detailed analysis of experimental gas permeation data through single layer graphene membranes under batch depletion conditions parametr... |
Summary form only given. Photonic crystals are one- or multi-dimensional periodic structures with periodicity length of the order of an optical wavelength. Photonic band structures are analogues to electronic bands, also showing frequency bands (photonic bandgaps) of inhibited optical modes. Research work on solid stat... |
The diagnosis and management of insomnia relies primarily on clinical history. However, patient self‐report of sleep–wake times may not agree with objective measurements. We hypothesized that those with shallow or fragmented sleep would under‐report sleep quantity, and that this might account for some of the mismatch. ... |
Numerous resolutions and agendas of abundant official meetings are composed in Bangla language. In this article, we have demonstrated a system that automatically discovers and extracts these decisions and agendas from the increasingly vast pool of official Bangla digital documents like Big Data and allow extraction, de... |
This work investigates whether traders' state-dependent expectations biases can account for anomalous country fund discount movements. I provide a multiple-agent asset pricing model that includes both rational traders and traders who display biases in expectations formation following market states with large amounts of... |
In the current MIL-STD-188-184 [184], the data link layer is hosted on the RED side of the communications security (COMSEC). This constrains the set of solutions available to the link layer. This paper analyses the possible benefits of moving the link layer to the black side of COMSEC in increasing throughput for a giv... |
The conformational behavior of a giant DNA mediated by condensing agents in the bulk solution has been investigated through experimental and theoretical approaches. Experimentally, a pronounced conformational hysteresis is observed for folding and unfolding processes, by increasing and decreasing the concentration of c... |
Within the broad domains of psychology and medicine, there is a sizable literature suggesting that not disclosing emotionally traumatic experiences can bring about physical and mental health problems. A theory of inhibition has been put forward that summarizes the process by which failure to confront emotionally trauma... |
A relatively simple nonlinear method for the seismic analysis of structures (the N2 method) is presented. It combines the pushover analysis of a multidegree-of-freedom (MDOF) model with the response spectrum analysis of an equivalent single-degree-of-freedom (SDOF) system. The method is formulated in the acceleration d... |
Recently, Industrial Light & Magic has begun exploring facial muscle simulation as a means of augmenting our blendshape-based facial animation workflow in order to attain higher quality results. During this process, we discovered that a precise and accurate model of the underlying facial anatomy is key to obtaining hig... |
Background: Xenoestrogens are compounds like estrogens in effect but not in structure which are mimicking the action of endogenous estrogen and activate estrogen receptor. Phytoestrogens are naturally occurring non-steroidal plant chemicals that can act like the female hormone estrogen. Aphanizomenon Flos-aquae (AFA) i... |
The present paper deals with the experimental measurement of absorption coefficients using (i) the differential dual-beam spectro-photometry method and (ii) an intra-cavity optical loss measurement technique. The absorption coefficient is measured experimentally in the region from the visible to the near IR. Criteria f... |
In pathogenic Neisseria species the type IV pili (Tfp) are of primary importance in host-pathogen interactions. Tfp mediate initial bacterial attachment to cell surfaces and formation of microcolonies via pilus-pilus interactions. Based on genome analysis, many non-pathogenic Neisseria species are predicted to express ... |
AIMS |
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer related mortality worldwide. The incidence is dramatically increasing and no effective systemic treatments are available accentuating the urgent need for novel treatment approaches. A growing body of evidence suggest th... |
METHODS |
The significance of COX-2 inhibition in HCCs was investigated in vitro (HCC cell-lines), in vivo (xenotransplanted tumors in nude mice) and ex vivo (precission-cut tissue sclice-cultures). Apoptosis-signaling was analyzed by means of immunohistochemistry, Western Blot analyses, Caspase-assays, FACS analyses after Nicol... |
RESULTS |
Selective COX-2 inhibition led to a marked tumor-specific growth inhibition of human HCCs in vitro, in vivo and ex vivo based on reduction of proliferation and induction of apoptosis. Both, the death receptor (extrinsic)-, as well as the mitochondrial (intrinsic)-apoptotic pathways were involved. COX-2 inhibition led t... |
CONCLUSION |
COX-2 inhibition offers therapeutic and preventive potential in HCC.Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy. |
Minimalist multifunctional platforms for delivering diagnostic and therapeutic agents effectively and safely into tumor sites are highly desired in nanomedicine. Herein, we describe the fabrication of a supramolecular nanoplatform via the amphiphilic amino acid (9-fluorenylmethyloxycarbonyl-l-leucine, Fmoc-l-L)-modulat... |
This paper presents a method for improving the buckling capacity of slender columns by employing functionally graded materials (FGMs) instead of isotropic materials in constructing these members. The volume fractions of FGM constituents are varied along the column length by a trigonometric function thereby causing vari... |
OBJECTIVE |
The Aligning Forces for Quality (AF4Q) initiative is the Robert Wood Johnson Foundation's (RWJF's) signature effort to increase the overall quality of healthcare in targeted communities throughout the country. In addition to sponsoring this 16-site, complex program, the RWJF funds an independent scientific evaluation t... |
STUDY DESIGN |
A descriptive overview of the evaluation research design for a multi-site, community based, healthcare quality improvement initiative is provided. |
METHODS |
The multiphase research design employed by the evaluation team is discussed. |
RESULTS |
Evaluation provides formative feedback to the RWJF, participants, and other interested audiences in real time; develops approaches to assess innovative and under-studied interventions; furthers the analysis and understanding of effective community-based collaborative work in healthcare; and helps to differentiate the v... |
CONCLUSIONS |
The AF4Q initiative is arguably the largest community-level healthcare improvement demonstration in the United States to date; it is being implemented at a time of rapid change in national healthcare policy. The implementation of large-scale, multi-site initiatives is becoming an increasingly common approach for addres... |
The authors of this report provide a framework for assessing a model's suitability to address policy questions regarding the coronavirus disease 2019 pandemic in the Commonwealth of Virginia. The authors suggest assessment criteria for early-stage and late-stage models that consider the effects of the pandemic on behav... |
ABSTRACT This paper examines the green energy transition objectives from a U.S. viewpoint. It is highly doubtful that targets announced by politicians, climate advocates and green investors will be achieved under-desired timeframes. The lack of a coherent domestic mineral policy, exceedingly long and burdensome permitt... |
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