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"This is just a book about a river. There was no quest involved, only a wish to understand more about this part of the country and my family's past," notes NoahAdams, a native of Ashland, Kentucky, who started his radio career in 1962 and has been a host to All Things Considered on National Public Radio for over eighte... |
Gilles de la Tourette syndrome is a chronic neuropsychiatric movement disease with combined motor tics and at least one vocal tic for a minimum period of 1 year. It typically begins in the childhood (under 18 years of age).Most of the patients with Tourette syndrome have comorbidities, which often impair their quality ... |
Abstract For imperial Britain, it has often been stated, the introduction and maintenance of the rule of law was a cardinal responsibility and indeed the great achievement of empire. But this is a view that has also been strongly challenged. For example, it has been argued that often at times of crisis, maintaining the... |
The goal of this Neighborhood Watch article is to provide some context on the use of factor VIIa (FVIIa) in management of hemophilic bleeding and discuss a recent article on engineering a novel FVIIa variant [1]. Even in this era of astonishing advances in the management of hemophilia, the development of antibodies to ... |
Arrhythmogenic cardiomyopathy (AC) is a heart disease caused by mutations in genes encoding for desmosomal proteins such as desmoglein 2 (Dsg2) and plakoglobin (Pg) and partially paralleled with skin defects. However, therapy is symptomatic to limit arrhythmia since the mechanisms by which desmosomal components control... |
Accumulation of insulator surface charge with DC loaded in vacuum is studied with electrostatic capacitive probe by measuring the surface charge of insulators of various roughnesses at different applied voltages and loading time. The measurement results indicate that the average surface charge density is affected by th... |
Latency-insensitive systems were recently proposed by Carloni et al. as a correct-by-construction methodology for single-clock system-on-a-chip (SoC) design using predesigned IP blocks. Their approach overcomes the problem of long latencies of global interconnects in deep-submicron technologies, while still maintaining... |
This study examines climatological potential vorticity streamer (PVS) activity associated with Rossby wave breaking (RWB), which can impact TC activity in the subtropical North Atlantic (NATL) basin via moisture and wind anomalies. PVSs are identified along the 2-PVU (1 PVU = 10−6 K kg−1 m2 s−1) contour on the 350-K is... |
A popular idea at present is that emotions are perceptions of values. Most defenders of this idea have interpreted it as the perceptual thesis that emotions present (rather than merely represent) evaluative states of affairs in the way sensory experiences present us with sensible aspects of the world. We argue against ... |
To study the role of hematopoietic microenvironment abnormality in development of minimal residual disease and its mechanism, the viability of HL-60 cells was investigated by means of bone marrow stromal cell culture system or co-culture system of bone marrow stromal cell with HL-60 cells and idarubicin (IDA), flow cyt... |
In the last decade, developers have been increasingly sharing their questions with each other through Question and Answer (Q&A) websites. As a result, these websites have become valuable knowledge repositories, covering a wealth of topics related to particular programming languages. This knowledge is even more useful a... |
Four hemocyte types have been identified in the late last larval instar of Galleria mellonella. Plasmatocytoids are round to spindle shaped cells, 10–20 μ long and 5–10 μ wide. The cytoplasm contains no distinguishing inclusions. Golgi complexes, rough endoplasmic reticulum and free ribosomes are abundant. Granular hem... |
An orbital solution for the MACHO∗05:34:41.3 -69:31:39 eclipsing binary system is presented, based on the published light curve and spectral data obtained with the 2.15-m telescope at CASLEO. Based on these spectroscopic observations, this system’s binary components were classified as O3 If∗ and O6:V respectively. The ... |
A simple estimate of the magnitude of the effective coupling constant between quarks and the gluon field is proposed, based on a consideration of the electric-charge dependence of the hadron mass differences for hadrons of identical composition. A comparison of the mass differences rho/sub +/-..pi../sub +/ and rho/sub ... |
Background Osteoporotic fractures are a serious complication in patients with cirrhosis. In addition to the high morbidity and mortality of the patients who suffer them, fragility fractures represent a high cost for Healthcare systems. However, there are very few studies that evaluate the prevalence of osteoporosis and... |
Do persons who utilize the services of the alternative therapist demonstrate a greater self-care response to illness? This cross-sectional study was done to compare the health perceptions and self-care response to minor illness among users of conventional medical care and alternative therapy. Data were collected with a... |
13 patients (1981-1991) between 1.5-15.5 years (average 10.2 years) with Delbet I-III fractures were analysed of the incidence of avascular necrosis. Only one (type II fracture) of our 13 patients was associated with a severe complication (Ratliff type I) of an avascular necrosis of the femoral head. This satisfactory ... |
ABSTRACT Faults in manufacturing processes can cause disruptions and downtime, which adversely affects process efficiency and increases production costs. Process downtime can be reduced by monitoring manufacturing processes for faults, categorizing those faults, and prioritizing action. A new approach is proposed for m... |
The rotor stoichiometry of F-ATPases has been revealed by the combined approaches of X-ray diffraction (XRD), electron crystallography, and atomic force microscopy (AFM). XRD showed the rotor from the yeast mitochondrial F-ATPase to contain 10 subunits. AFM was used to visualize the tetradecameric chloroplast rotors, a... |
In this article, it is presented a mathematical model for the additional financial value generated in software projects, as a function of the number of incremental deliveries during the project. Based on this model, it was presented the theoretical asymptotic limit, for infinite deliveries during the project. This prac... |
High-sensitivity troponin T (hsTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) strongly predict heart failure (HF) in the general population. However, the interpretation of levels of these biomarkers as predictors of HF is uncertain among patients with CKD. Here, we investigated whether hsTnT and NT-proB... |
The rehabilitation of the concept of authority is one of the more contentious positions advocated by Gadamer in Truth and Method (1960). Habermas in particular challenged the universality of Gadamer’s hermeneutic project by presenting this rehabilitation as a conservative legitimation of prevailing prejudices which tru... |
JIGSAW is a well-known technique for collaborative learning. Students typically use it in a face-to-face setting without computer support. This paper describes a Web-based tool for both the preparation of the collaborative learning activities and the execution of the activities. The teachers design and prepare collabor... |
This paper describes the lattice Boltzmann, numerical simulations used to evaluate a conduction-based PCR device (U. Texas) for uniformity of the micro channel temperature profile and its velocity field distribution. For comparison purposes, numerical simulations were also performed using conventional PCR configuration... |
We investigate the use of multiword query features to improve the eeectiveness of text-retrieval systems that accept natural-language queries. A relevance feedback process is explained that expands an initial query with single and multiword features. The multiword features are modelled as a set of words appearing withi... |
RATIONALE |
Daily azithromycin decreases acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but long-term side effects are unknown. |
OBJECTIVES |
To identify the types of exacerbations most likely to be reduced and clinical subgroups most likely to benefit from azithromycin, 250 mg daily, added to usual care. |
METHODS |
Enrollment criteria included irreversible airflow limitation and AECOPD requiring corticosteroids, emergency department visit, or hospitalization in the prior year or use of supplemental oxygen. Recurrent events and cumulative incidence analyses compared treatment received for AECOPD by randomization group, stratified ... |
MEASUREMENTS AND MAIN RESULTS |
Azithromycin was most effective in reducing AECOPD requiring both antibiotic and steroid treatment (n = 1,113; cumulative incidence analysis, P = 0.0002; recurrent events analysis, P = 0.002). No difference in treatment response by sex (P = 0.75), presence of chronic bronchitis (P = 0.19), concomitant inhaled therapy (... |
CONCLUSIONS |
Azithromycin is most effective in preventing AECOPD requiring both antibiotic and steroid treatment. Adjusting for confounders, we saw no difference in efficacy by sex, history of chronic bronchitis, oxygen use, or concomitant COPD therapy. Greater efficacy was seen in older patients and milder Global Initiative for Ch... |
Consider a situation where a secret agent wants to authenticate herself to the other secret agents. This secret agent must be able to convince the others of her identity. She cannot convince any other people other than those predetermined secret agents. This is to avoid problems that might occur if this secret agent wo... |
The term online peer-to-peer lending (P2P) describes the loan origination process between private individuals on online platforms were financial institutions operate only as intermediates required by law. Initialized by groups in online social networks, first commercial online P2P lending platforms started in 2005. Thu... |
Gap junctions (GJ) allow direct intercellular communication, and consist of connexins (Cx). In the mammalian central nervous system, oligodendrocytes express Cx29, Cx32 and Cx47, whereas astrocytes express Cx26, Cx30 and Cx43. Cx47/Cx47 GJs couple oligodendrocytes, and Cx47/Cx43 channels are the primary heterotypic GJs... |
One of the main applications of electrophoretic 2‐D gels is the analysis of differential responses between different conditions. For this reason, specific spots are present in one of the images, but not in the other. In some other occasions, the same experiment is repeated between 2 and 12 times in order to increase st... |
Due to increasing complex structures, such as multiple metal layers, high density circuits, and wide metal buses, on a die of an integrated circuit (IC) and specially packaged devices, such as flip chips and lead on chips, the traditional front side emission microscopy is no longer effective or cannot be applied. The b... |
Rumor spread in social media severely jeopardizes the credibility of online content. Thus, automatic debunking of rumors is of great importance to keep social media a healthy environment. While facing a dubious claim, people often dispute its truthfulness sporadically in their posts containing various cues, which can f... |
This paper presents a simple bootstrap procedure to develop multivariate confidence intervals for tourist expenditure profiles and consequent estimates of economic impacts per thousand tourist vis- its. Mean expenditures from replicated visitor expenditure data in- cluded weights to correct for response bias. A covaria... |
This paper evaluates relations between industrial activity and the structure of countries' financial, ownership and legal systems. Using data on 27 industries in 14 OECD countries over the period 1970 to 1995, we evaluate whether the structure of countries' systems is associated with different types of economic activit... |
Mutans streptococci have been shown to give rise to variants in terms of expression of surface protein antigens by repeated subculturing of the organisms, which in turn induces changes in colonial morphologies. A 2,850-bp upstream region of the gene (pag) for a surface protein antigen, PAg, of Streptococcus sobrinus MT... |
Report on a series of patients suffering from cerebrovascular insufficiency caused by stenosis and/or occlusion of one or several major cerebral vessels. The patients were divided in two groups, one being medically treated with anticoagulants, the other operated on either a carotid artery thrombosis by thromboendartere... |
Taking inspiration from the biological world, in our work we are attempting to create and examine artificial predator-prey relationships using two LEGO robots. We do so to explore the possible adaptive value of emotion-like states for action selection in this context. However, we also aim to study and consider these co... |
In this paper, an optical structure for the aircraft was considered and its vibrational characteristics and weight were optimised using the robust design technology. To acquire the vibration characteristics and the stable line of sight, modal analyses were performed to the optical structure using the commercial multi-b... |
The European Commission proposes a pan-European support for short-time work arrangements (SURE). This column discusses the relationship between this proposal and the idea of a European unemployment re-insurance scheme, to which the Commission also refers in its Communication on SURE. We sketch the merits of SURE and si... |
This work deals with the application of the Radial Basis Function (RBF) to the solution of two convectivediffusive problems. The first problem is the classical lid-driven cavity flow and the second problem is the natural convection problem inside a square cavity which is heated at two different temperature levels in th... |
Instructional designers face the constant challenge of balancing many considerations affecting learning. Of all the guidelines from research offering advice on these matters, few are more challenging than those dealing with cognitive load. How much is too much? Is cognitive load always bad? In this article, two authors... |
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