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Actor-network theory (ANT) has achieved a measure of popularity in the analysis of information systems. This paper looks at ANT from the perspective of the social realism of Margaret Archer. It argues that the main issue with ANT from a realist perspective is its adoption of a `flat' ontology, particularly with regard ... |
Purpose: To investigate the roles of vascular dysregulation and inflammation in normal-tension glaucoma (NTG), we determined the plasma levels of endothelin-1 (ET-1), matrix metalloproteinase-9 (MMP-9), macrophage chemoattractant protein-1 (MCP-1), and high-sensitivity C-reactive protein (hs-CRP). Materials and methods... |
How do Muslims in different parts of the world recite and how do they hear the sound of the Qur'an? What are the purposes of their recitation, and what meanings do they associate with it? In this article I analyse one ritual performance of Qur'anic recitation and dhikr conducted by Uyghur village women in the Xinjiang ... |
Abstract Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation a... |
BACKGROUND |
Hereditary angioedema is characterized by recurrent and unpredictable swellings that are disabling and potentially fatal. Selective inhibition of plasma prekallikrein production by antisense oligonucleotide treatment (donidalorsen) may reduce the frequency of attacks and the burden of disease. |
METHODS |
In this phase 2 trial, we randomly assigned, in a 2:1 ratio, patients with hereditary angioedema with C1 inhibitor deficiency to receive four subcutaneous doses of either donidalorsen (80 mg) or placebo, with one dose administered every 4 weeks. The primary end point was the time-normalized number of investigator-confi... |
RESULTS |
A total of 20 patients were enrolled, of whom 14 were randomly assigned to receive donidalorsen and 6 to receive placebo. The mean monthly rate of investigator-confirmed angioedema attacks was 0.23 (95% confidence interval [CI], 0.08 to 0.39) among patients receiving donidalorsen and 2.21 (95% CI, 0.58 to 3.85) among p... |
CONCLUSIONS |
Among patients with hereditary angioedema, donidalorsen treatment resulted in a significantly lower rate of angioedema attacks than placebo in this small, phase 2 trial. (Funded by Ionis Pharmaceuticals; ISIS 721744-CS2 ClinicalTrials.gov number, NCT04030598.).Factors associated with baseline and serial changes in circ... |
Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) associate with structural heart disease and heart failure risk in individuals without known cardiovascular disease (CVD). However, few data are available regarding whether factors influencing levels of these two... |
Attempts to identify physiological correlates of listening effort have mainly focused on peripheral measures (e.g. pupillometry) and auditory-evoked/event-related potentials. Although nonauditory studies have suggested that sustained time–frequency electroencephalographic (EEG) features in the &thgr;-band (4–7 Hz) are ... |
The combined use of silanes (Et3SiH or PMHS) and I2 as novel N-glycosidation reagents for the synthesis of bioactive oxathiolane nucleosides 3TC and FTC is reported. Both systems (working as anhydrous HI sources) were devised to act as substrate activators and N-glycosidation promoters. Excellent results in terms of ch... |
Objective: The present study was designed to evaluate the impact of Education (Edu) vaccine in National Program for Prevention and Eradication of Heart Attack (NPPEHA). Methods: This pretest–posttest designed study was held in the SAAOL Heart Center in different cities (Delhi, Kolkata, Bangalore, and Mumbai) of India f... |
Iterative dual-space direct methods based on phase refinement in reciprocal space and peak picking in real space are able to locate relatively large numbers of anomalous scatterers efficiently from MAD or SAD data. Truncation of the data at a particular resolution, typically in the range 3.0-3.5 A, can be critical to s... |
The presence of atrial natriuretic factor (ANF) has been demonstrated in striated myocytes of the human embryonic heart as well as in the adult heart, by immunohistochemical and immunocytochemical methods. The postconceptional age of the embryos ranged from 8 to 9 weeks. At this early stage of development, shortly afte... |
Virus-free plants of 8 monoembryonic cultivars of Citrus Clementina Hort ex Tan. were obtained by somatic embryogenesis of the nucellus cultured in vitro. Twenty-nine percent of them had abnormal phenotypic characters that were maintained for 7 years in the greenhouse, and by bud wood propagation on different rootstock... |
This paper revisits the paradox of flexibility, ie, the result that, in a liquidity trap, greater price flexibility amplifies output volatility in response to negative demand shocks. We argue this paradox is the consequence of a failure of standard models to correctly characterise monetary policy and that allowing for ... |
Ethnic and racial disparities in mental health are driven by social factors such as housing, education, and income. Many of these social factors are different for minorities than they are for whites. Policies that address gaps in these social factors therefore can address mental health status disparities. We analyze th... |
A micro ultrasonic scalpel based on a piezoelectric film transducer can cut very soft and small objects with slight deformation and monitor the vibration condition during operation. The micro ultrasonic scalpel has longitudinal vibration component and also lateral vibration component for effective cutting performance. ... |
The work is founded on the results of examination and treatment of 1242 patients with acute pancreatits in 1991-2007. There was compared results of diagnostics and treatment of 520 patients in 1991-1999 (group of comparison) before insertion of protocols of diagnostics and treatment of acute pancreatitis and after thei... |
Blood levels, tissue distribution and excretion of (2''R)-4'-O-tetrahydropyranyladriamycin (THP) were studied in rats received 14C-THP or unlabeled THP at a dose of 5 mg/kg, respectively. The THP disappeared rapidly from the blood and transferred to tissues immediately after an administration. Pharmacokinetic analysis ... |
We describe a novel tempo estimation method based on decomposing musical audio into sources using principal latent component analysis (PLCA). The approach is motivated by the observation that in rhythmically complex music, some layers may be more rhythmically regular than the overall mix, thus facilitating tempo detect... |
This is the second of a two-part series on the legacy of Mihaly Csikszentmihalyi, contributed by Barbara Schneider. You can read the first one here. We are taking a winter break, so you won’t be receiving Tip of the Week the next two Sundays. Happy holidays, and see you in January! When I was in 10th grade, biology was... |
Introduction: Damage to hippocampus can occur through ischemia. Memory problems are among the most significant disabilities after stroke. Therefore, improving memory is of great interest in helping post-stroke patients. This study demonstrated that intraperitoneally injection of atorvastatin with a short cycle of isc... |
Materials and methods: In this article survey, we used 64 animals. Rats were divided into 8 groups, (n=8). Group 1: control; group 2: sham; group 3: global cerebral ischemia (GCI) only; group 4: remote ischemic preconditioning (RIP) + GCI; group 5: GCI + atorvastatin (ATO); group 6: GCI + vehicle; group 7: RIP + G... |
Results and discussion: Remote ischemic preconditioning could improve rats performance in water maze tests along with a decrease in neuronal death. Also, atorvastatin combined with remote ischemic preconditioning was more effective for memory improvement and reduction of neuronal death. Inconsistent with our result,... |
Conclusion: This study showed that remote ischemic preconditioning with atorvastatin could improve CA1 neuronal injury and memory. |
Graphical abstract: |
Effect of urea on the ion-association capillary electrophoresis separation of the anionic metal complexes using hydrophobic tetraalkylammonium as ion-association agent. |
The effect of urea as an electrophoretic buffer solution modifier on the ion-association (IA) capillary electrophoresis (CE) separation of four anionic metal complexes of Al(III), Co(III), Cr(III), and Fe(III) with 2,2'-dihydroxyazobenezene-5,5'-disulfonate (DHABS) using a hydrophobic ion-association agent, tetrapentyl... |
The balance of a practical hands-on and theoretical approach for reverse engineering coursework offers a strong approach for cybersecurity education. This balance is key to helping students build the skills necessary to contribute to the industry upon graduation. However, the remote learning demands of the current pand... |
This paper aims to identify potential explanatory variables of the entrepreneurial orientation and innovation capacity (EO-IC) of family enterprises (FEs) through a comparative study of family businesses in Spain and Latin America. The innovation literature reports a paradigm shift whereby the dynamic boost provided by... |
In Untimely Interventions, Ross Chambers claims that the constellation of texts known as witnessing or testimonial serve as (often unwelcome) wake-up calls in the midst of a culture that would rather remain senseless to the disaster they evoke. Through his analysis of the singular workings of texts from a broad cross-s... |
Out of a population of 61 patients with sex chromosome aberrations we could examine 25 patients with Klinefelter's syndrome and one female patient with triple X syndrome for taurodontism. Taurodontic molars were found in 6 out of 25 patients with Klinefelter's syndrome and in the patient with triple X syndrome.Internet... |
The demand for global healthcare systems for human health improvement is ever growing. Internet of things (IoT) has influenced every industry in the market. IoT-based healthcare monitoring systems have emerged using smart gateways between sensor networks and the internet. This chapter aims at focusing on the impact of ... |
BACKGROUND |
Little is known about the prevalence of subjective or perceived memory difficulties in the general population. This is of particular interest in the field of menopause as self-reported memory difficulties make up a large proportion of complaints by women presenting at specialist menopause clinics. There is also a gener... |
AIM |
To investigate the prevalence of perceived memory difficulties in women to establish whether there are variations with menopausal status and age. |
DESIGN OF STUDY |
Cross-sectional questionnaire study. |
SETTING |
Sheffield, United Kingdom. |
METHOD |
Standardised questionnaires assessing subjective memory, mood and menopausal symptoms were sent to a random sample of 400 women, aged 25-64 years, identified from a general practice list. Menopausal status and demographic details were also recorded. Two hundred and two women responded, giving a response rate of 50.5%. |
RESULTS |
The prevalence of perceived memory difficulties was low, and did not differ on the basis of menopausal status or age. Anxiety and depressive symptoms were the main significant predictors of perceived memory difficulties. |
CONCLUSION |
Perceived memory difficulties are not specific to particular stages of the life cycle or age, but are experienced to a greater degree by those with high levels of depressive or anxiety symptoms.Do ED patients with migraine headaches meet internationally accepted criteria? |
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