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The search for a substrate that may serve as a probe to quantitatively predict the in vivo kinetics of cytochrome P450 3A (CYP3A) drugs has been of particular interest because more than half of all human drugs appear to be substrates for this enzyme. Even three closely related 1,4-benzodiazepines-alprazolam, midazolam,... |
Much effort has been invested in seeking to understand the thermodynamic basis of helix stability in both peptides and proteins. Recently, several groups have measured the helix-forming propensities of individual residues (Lyu, P.C., Liff, M.I., Marky, L.A., Kallenbach, N.R. Science 250:669-673, 1990; O'Neil, K.T., DeG... |
Recent work ([18], [1]) has produced a complete list of weighted homogeneous surface singularities admitting smoothings whose Milnor fibre has only trivial rational homology (a "rational homology disk"). Though these special singularities form an unfamiliar class and are rarely even log-canonical, we prove the |
Theorem. A rational homology disk smoothing of a weighted homogeneous surface singularity can always be chosen so that the total space is log-terminal. In particular, this smoothing is $\Q$-Gorenstein. |
The key idea is to define a finite "graded discrepancy" of a normal graded domain with $\Q$-Cartier canonical divisor, and to study its behavior for a smoothing.The relationship between maternal height and weight at booking and perinatal mortality. |
In this study, more of the Coloured women weighed less than 45 kg and more of them were significantly shorter than Black and White women. The short (less than 149 cm) Coloureds had a high perinatal mortality, as did the thin Coloureds (less than 45 kg). The short, thin Coloured women had the highest perinatal mortality... |
We report molecular dynamics (MD) simulations to explore the influence of a counterion on the structure and dynamics of cationic and anionic solvation shells for various ions in methanol at 298 K. We show that the variation in ionic size of either the cation or the anion in an ion pair influences the solvation structur... |
Ultrasound-enhanced thrombolysis, or sonothrombolysis, has been actively investigated due to its relatively high efficiency and better safeness compared with traditional thrombolysis methods such as mechanical thrombectomy and pharmaceutical treatment. Most of the ultrasound devices, however, are fabricated with non-bi... |
In this paper we investigated the usefulness of measuring users' eye movements as a tool for the evaluation of the user interface elements such as sliding banners. Sliding banners allow multiple pieces of content to occupy a single, coveted space, but on large or small view ports, people often scroll past sliding banne... |
Eighty-nine patients with carcinoma of the cervix received radical radiation therapy from May 1981 through 1983 at the hospital of the National Institute of Radiological Sciences. After a 2 to 4 year follow-up, primary cancer was found to be controlled in 59 patients, a recurrence was noted in 16 patients but 12 patien... |
It has become a cliché: Globalization is occurring at a faster rate than ever before and its impact is influencing rapid change around the globe. It affects how individuals live, communicate, plan, age, and die. It affects cultural and environmental evolution and organizational sustainability or death. In short, global... |
Agriculture accounts for more than 50% of freshwater withdrawal in the Mediterranean. Data-enabled technologies, such as Internet of Things (IoT), can play an important role in boosting water and energy use efficiency and improving crop productivity, by increasing the reliability and accuracy of real-time information. ... |
Protein phosphatase inhibitor-1 (I-1) has been proposed as a regulatory element in the signal transduction cascade that couples postsynaptic calcium influx to long-term changes in synaptic strength. We have evaluated this model using mice lacking I-1. Recordings made in slices prepared from mutant animals and also in a... |
The International Classification of Impairments, Disabilities, and Handicaps (ICIDH) is gaining wide acceptance inside and outside the field of rehabilitation medicine. Impairment and disability are concepts which are often used interchangeably or defined differently. The World Health Organization (WHO) has defined imp... |
Although there is consensus that microorganisms significantly influence uranium speciation and mobility in the subsurface under circumneutral conditions, microbiologically mediated U(VI) redox cycling under alkaline conditions relevant to the geological disposal of cementitious intermediate level radioactive waste, rem... |
Telomeres are protein‐nucleotide sequences at the ends of chromosomes that serve to prevent the loss of genetic information during cell replication. A telomerase ribonucleoprotein complex includes telomerase reverse transcriptase (TERT) and an RNA template (TER) and is responsible for adding telomeric DNA. Our lab has ... |
Diabetes mellitus is associated with dangerous vascular complications, including diabetic retinopathy (DR), which can lead to complete visionloss. Modern diagnostic methods, such as optical coherent tomography, help accurately and objectively verify the stage of DR, thus providing an opportunity to choose a treatment a... |
The current situation in the field of automation requires increasingly sophisticated flexible and adaptive solutions. Construction of modular machinery appears to be an effective tool to meet these requirements. Solution of design layout module with rotary motion linkage is designed for machines with unlimited rotary m... |
The trajectory tracking control problem of the quad-rotor is investigated in this paper. After introducing the dynamic equations of motion of a quad-rotor, considering the quad-rotor's characteristics like strong coupling, nonlinearity and under-actuation, the trajectory tracking is realized by proposing an effective a... |
Abstract: It is characterized by severe uterine pain during menstruation. It is a very common complaint, experienced by 45-95% of reproductive age group women. Prostaglandins are known to increase myometrial contraction and constrict small endometrial blood vessels to produce ischemia and pain, the aim of the study is ... |
In Anesthesia, especially in Cardiac Anesthesia in germany exist a lots of standards, that define good quality. For external quality assurance and analysis there is a core data set defined with an extension for cardiac anesthesia for a survey of patient risk factors und complications. Because there is no obligation onl... |
The attitude of a spacecraft is usually controlled by 3 reaction wheels. However, to prepare an accident of the wheel, it is important to consider the attitude control by 2 wheels. Especially, when the initial angular momentum of the system is not zero, the system has a drift term and it cannot control the attitude arb... |
Two-dimensional transition metal dichalcogenides (TMDC) and MoS2 in particular are promising materials as sensitive layers for gas sensing due to room operation temperature, high sensitivity, low dimensions, vast methods of selectivity alteration, etc. MoS2 response to toxic gases exposure depends on applied electric f... |
More recenitly Weber2 has published the results of a trial of traction in 72 patients, which showed no advantage for this form of treatment in patients with lumbago and sciatica. The control procedure used was homoeopathic traction; the traction used for treatment was given on a split couch with a force of one-third of... |
An important component in protecting the ecological quality of watercourses is the regulation of point source discharges. These are usually expressed in terms of "end of pipe" limits on certain physical parameters or on the concentrations of specific chemicals. Sometimes discharge licences take the form of Emission Lim... |
Wireless sensor nodes are mostly used in extreme en vironments, especially at remote and hostile areas including battlefield, volcanoes and underwater. Th us, it is difficult to replenish the energy source of the sensor node once it is installed. In order to prolo ng the lifetime of the nodes, we propose a new rout ing... |
Sequences required for a faithful and efficient transcription of a cloned mouse ribosomal RNA gene (rDNA) are determined by testing a series of deletion mutants in an in vitro transcription system utilizing two kinds of mouse cellular extract. Deletion of sequences upstream of -40 or downstream of +52 causes only sligh... |
ABSTRACT Objective: Benign familial infantile epilepsy (BFIE) is an autosomal dominant epilepsy syndrome characterized by afebrile seizures beginning at about 6 months of age. Mutations in PRRT2, encoding the proline-rich transmembrane protein 2 gene, have recently been identified in the majority of families with BFIE ... |
Tissue banks are critical to research efforts into the causes and treatment of many diseases. Biobanks are created from donated tissue but property concepts have not played a major role in understanding methods of the collection and use of tissue. Little work has been done to study the proprietary dimensions of these g... |
The pathogenesis of the acquired immune deficiency syndrome (AIDS) is still unknown. However, it appears to develop in the milieu of prolonged immunodeficiency. Recently, the disease has reached almost epidemic proportions among homosexuals. Patients with AIDS present primarily with disseminated Kaposi's sarcoma and/or... |
Mestranol, the estrogen component of some oral contraceptive formulations, must be demethylated to its active metabolite, 17α‐ethinyl estradiol, to produce estrogenic activity. To investigate the transformation of mestranol to ethinyl estradiol, an in vitro assay was used with human liver microsomes from four different... |
In this paper, we propose and analyze a new compressive Fourier phase retrieval (PR) technique based on differential measurement, that can provably recover sparse signals with O(s polylog N) phase-less measurements. This measurement technique is easily implementable using interferometric techniques like Holography and ... |
Porous silicon nanowires have been well studied for various applications; however, there are only very limited reports on porous silicon nanowires used for energy storage. Here, we report both experimental and theoretical studies of porous doped silicon nanowires synthesized by direct etching of boron-doped silicon waf... |
Machine learning has been applied to classify chest X-ray images into pneumonia-positive and pneumonia-negative classes to allow an early diagnosis and support medical experts’ decision about pneumonia. However, the previous attempts in this literature focus on binary classification that may not consider the possibilit... |
This paper is intended for new faculty and faculty who are new to using digital technologies and a learning management system in their instruction. As experienced faculty in the College of Education, the authors make a concerted effort to support faculty in their use of instructional technology. In this paper, the auth... |
A fusion between the genes for bacteriorhodopsin and beta-galactosidase was constructed on a multicopy plasmid, pXB/Gal 101. The fusion gene, containing the bacteriorhodopsin gene fused upstream from the beta-galactosidase gene, was under the control of tandem lipoprotein and lac gene promoters. When expressed in Esche... |
Valine deficiency in rats produced motor incoordination attributable to selective damage to the red nuclei, midbrain structures that modulate motor activity. Neither incoordination nor red nuclei damage occurs in rats deprived of valine, isoleucine and leucine, thus suggesting that valine neurotoxicity results from ami... |
Newly synthesized proteins undergo chaperone‐assisted folding into a functional conformation. However, various insults can disrupt protein folding, including environmental stressors, defects in translation and/or post‐translational processing, or genetic mutations. Improperly folded proteins may either attain their pro... |
Empathy is related to a variety of prosocial behaviors, but the brain mechanisms producing the experience of empathy have not been fully characterized. This study investigated whether the experience of empathy raises oxytocin levels and affects subsequent generosity toward strangers. Short video clips of an emotional s... |
are a list of 24 references &dquo;Current Textbooks in Tests, Measurement, and Evaluation,&dquo; a &dquo;Textbook Reference Chart&dquo; which correlate the chapters or selected articles in the second edition of this anthology with the relevant chapters of the 24 textbooks. The anthology concludes with a bibliography of... |
Wafer-level optics is considered as a cost-effective approach to miniaturized cameras, because fabrication and assembly are carried out for thousands of lenses in parallel. However, in most cases the micro-optical fabrication process is not mature enough to reach the required accuracy of the optical elements, which may... |
OBJECTIVES |
This study describes state legislators' knowledge, attitudes, and voting intentions with regard to tobacco-related issues. |
METHODS |
A cross-sectional survey of state legislators was conducted in North Carolina, Texas, and Vermont in 1994. |
RESULTS |
Most legislators agreed that secondhand smoke can cause lung cancer in nonsmokers, and a majority believed that smokers are addicted to nicotine. More than 75% stated that they would support a measure to enforce laws preventing tobacco sales to youth. A majority of Texas and Vermont legislators supported an increase in... |
CONCLUSIONS |
State legislators believe tobacco to be addictive, and they support policies to protect youth from tobacco. Support for other legislative measures differs significantly across states.An Improved Neighborhood-Restricted Association Rule-based Recommender System |
Association rule mining is an actively studied topic in recommender systems. A major limitation of an association rule-based recommender system is the problem of reduced coverage. It is generally caused due to the usage of a single global minimum support (minsup) threshold in the mining process, which leads to the effe... |
Objective: To establish the validity, reliability, and discriminative properties of the AD8, a brief informant interview to detect dementia, in a clinic sample. Methods: We evaluated 255 patient–informant dyads. We compared the number of endorsed AD8 items with an independently derived Clinical Dementia Rating (CDR) an... |
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