text
stringlengths
0
10.1k
INTRODUCTION: Data demonstrates the benefits of Long Acting Reversible Contraceptives (LARC) to reduce unintended pregnancy. In 2014, the Centers for Disease Control and the U.S. Office of Population Affairs issued guidelines for Quality Family Planning services that emphasized a client centered approach to help indivi...
There is a great deal of interest in using large scale brain imaging studies to understand how brain connectivity evolves over time for an individual and how it varies over different levels/quantiles of cognitive function. To do so, one typically performs so-called tractography procedures on diffusion MR brain images a...
BACKGROUND
The precise analysis of tumour markers in blood such as circulating cell-free DNA (cfDNA) could have a significant impact in facilitating monitoring of patients after initial therapy. Although high levels of total cfDNA in plasma of cancer patients are consistently demonstrated, a low sensitivity of DNA alterations is ...
OBJECTIVE
The major question regards the recovery of tumour-specific cfDNA such as KRAS mutated DNA and cancer-associated type 16 of human papillomavirus (HPV16).
METHODS
TaqMan technology was used for detection of KRAS mutation, HPV16 and to quantify cfDNA in blood plasma.
RESULTS
Comparison of four different column-based commercial kits shows that the cfDNA purification carried out by the Genomic Mini AX Body Fluids kit and the QIAamp Circulating Nucleic Acid kit gave us the possibility to improve the sensitivity of detection of KRAS mutation and HPV16. The optimized method was used to follow t...
CONCLUSIONS
Data presented in this study facilitate detection of tumour-specific cfDNA and improve standards needed for the implementation of cfDNA technology into routine clinical practice.Greek Orthodox Christian Anthropology and Person—Centered Approach to Education: Tentative Tracing of Their Parallel Paths and Exploration of ...
Our purpose is the tracing of the possible parallel paths between Eastern Christian Orthodox anthropology and Carl Rogers's person-centered approach to education (PCA) and the investigation of their compatibility. Referring to the work of the Holy Fathers we study three basic elements of Greek Orthodox Christian theolo...
The purpose of this grounded theory study was to understand sexual risk-taking behavior among Taiwanese youth. Thirty-six participants were purposively selected for two to three semistructured, in-depth individual interviews. The constant comparative method and coding process were used for data analysis. The core categ...
A well-documented observation after eccentric exercise is a reduction in maximal voluntary force. However, little is known about the ability to maintain maximal isometric force or generate and maintain dynamic peak power. These aspects of muscle function were studied in seven participants (5 males, 2 females). Knee ext...
The paper provides a short research biography of A. M. Mandelschtam (1920–1983), one of the leading authorities in the archaeology of Central Asia, an expert in the study of the steppe and nomadic cultures of Central Asia and South Siberia. Mandelschtam’s long and active expedition- ary activity in Tajikistan during th...
Summary
Despite the fact that vomiting is a very common symptom, spontaneous rupture of the oesophagus is very rare. The probable mechanism of spontaneous rupture is described.
The disease is discussed from a historical, clinical and radiological point of view. A brief description of the surgical treatment and prognosis is given. The importance of early diagnosis is stressed.Data Presentation for Quality Improvement
Efforts to improve quality of medical care often involve large data sets. Reviewing laboratory results over time for a cohort of patients is particularly problematic: traditional statistics conflate case to case variations with day to day variations (within a case). To help solve this problem, we propose using sparklin...
Ensuring that the experiences provided by Extension, including those associated with the 4-H program, are impactful to participants is of paramount importance. To ensure the continued success and relevance of the 4-H program, it is crucial for practitioners to measure the impact of 4-H involvement and use these results...
Introduction: There are two different therapeutic concepts of endothelin receptor antagonism: blocking receptor subtype A (ET A R; selective antagonism) and blocking subtypes A and B (ET B R) (dual antagonism). Anti-inflammatory effects of endothelin receptor antagonists (ERA) have been shown, but little is known about...
We studied the hemodynamic response to intravenous nitroglycerin (NTG) in 40 patients with and without acute heart failure (hemodynamic subsets I-IV) during acute myocardial infarction. Hemodynamic measurements were performed by right heart catheterization. The results showed that NTG response influenced mainly the pre...
Incorporating topic level estimation into language models has been shown to be beneficial for information retrieval (IR) models such as cluster-based retrieval and LDA-based document representation. Neural embedding models, such as paragraph vector (PV) models, on the other hand have shown their effectiveness and effic...
Chinese films in “the Chinese century” are more expansively confident than ever. A new vogue for science fiction, a genre that has taken off in China alongside the country's stratospheric growth, suggests that China is ready to take up the baton of galactic discovery adventure. Chris Berry examines the father-son narra...
The main problem still remains a rather low level of useful use of associated components of oil production and, consequently, a high percentage of combustion of associated hydrocarbon compounds. In addition, companies are increasing the amount of costs aimed at reducing volatile organic compounds and nitrogen oxide eve...
The flexible AC transmission system (FACTS) in a power system improves the stability, reduces the losses, reduces the cost of generation and also improves the loadability of the system. In the proposed work, a non-traditional optimization technique, a Genetic Algorithm (GA) is conjunction with Fuzzy logic (FL) is used ...
Seed dispersal effectiveness (SDE) is the contribution of dispersers to plant recruitment and is estimated as the product of the number of seeds dispersed (quantity) and the probability of recruitment of each dispersed seed (quality). Although SDE is a key concept in seed dispersal ecology, few studies estimate SDE and...
OBJECTIVE
To study the involvement in research, of final year medical students and fresh graduates of Karachi, Pakistan and to identify the factors influencing their interest in medical research.
METHODS
A cross-sectional, questionnaire based study was conducted in 2007-2008. Five institutes representing the private and public hospitals in the city were selected by cluster sampling. Final year medical students and fresh graduates were included. Descriptive statistics were charted using SPSS v.16 after double data entry...
RESULTS
Out of 378, 186 (49%) participants had journal reading habits due to the requirement of their institution. Mostly, 157 (41%) undergraduates had already participated in a research project, however mostly in the field as data collectors or computer work. Institutional influence and speciality of interest was found to be ...
CONCLUSION
There is keen interest and involvement in research, among final year medical students and fresh graduates of Karachi, Pakistan. However, the factors driving them are based on their university research encouragements and future plans.Shared Decision-Making in the Context of Uncertain Care Goals and Outcomes: Dissecting ...
Surgeons care deeply about their patients, their patient’s surgical outcomes, and their fund of knowledge as it relates to disease, treatment options, and risk is remarkable. Unfortunately, surgical patients’ values, hopes, fears, and unacceptable levels of suffering are rarely elicited and addressed while constructing...
OBJECTIVE
Because the second and third tarsometatarsal (TMT) and naviculocuneiform joints normally communicate, the least arthritic or technically most straightforward joint was injected when a fluoroscopically guided therapeutic injection was ordered for one or both joints. We hypothesized that pain relief would be equivalent r...
MATERIALS AND METHODS
Seventy-eight patients were divided into four joint groups: naviculocuneiform requested and injected (n = 15), nonrequested naviculocuneiform or second and third TMT injected (n = 25), both injected (n = 23), and TMT requested and injected (n = 15). Variables recorded included patient age and sex, fluoroscopy time, ste...
RESULTS
Pre- and postinjection pain reduction (p = 0.630) and postinjection pain (p = 0.935) were not significantly different. Mean steroid dose (p < 0.001) and fluoroscopy time (p = 0.0001) were significantly increased for the both joint injection group. Within the nonrequested naviculocuneiform or second and third TMT inject...
CONCLUSION
When faced with challenging naviculocuneiform or second and third TMT joint injections, choosing the technically most straightforward joint may result in less radiation and steroid dose without compromising quality of care or pain reduction.EARLY RECOVERY OF COMET 55P/TEMPEL-TUTTLE
We present recovery observations of the parent of the Leonid meteor stream – comet 55P/Tempel-Tuttle using the Keck II telescope. At recovery, the comet was at r = 4.5 AU, with mR = 22.6, and there was no indication of coma or activity. Preand post-recovery observations from 6 observing runs (1994–1997 June) are presen...
Government decisions to reduce the defence budget and lower strategic ambitions have prompted the British Army to undertake its most radical reorganisation for 50 years. The long-term viability of the project relies on the successful withdrawal from combat operations in Afghanistan and a significant increase in the uti...
Job demands are viewed as the physical, psychological and social effects of the physical and mental efforts required by the job on the employee, while job resources refer to the gains and opportunities that reduce these effects, support employee development and help him/her achieve successful results. The aim of this s...
Objective: To examine the relation between a parental history of hypertension and blood pressure and cardiac structure in children aged 8–10 years. Design: Cross-sectional study of a sample of children drawn from a population survey of coronary risk factors in children. Setting: Odense, Denmark. Subjects: Sixty-nine ch...
A strand is a sequence of events; it represents either the execution of an action by a legitimate party in a security protocol or else a sequence of actions by a penetrator. A strand space is a collection of strands, equipped with a graph structure generated by causal interaction. In this framework, protocol correctnes...
This article examines the impact of leveraged buyout firms' bank relationships on the terms of their syndicated loans. We examine a sample of 1,590 loans financing private equity sponsored leveraged buyouts between 1993 and 2005, and find that private equity firms' bank relationships are an important factor in cross-se...