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sense_dimmed_sleep/nonobesepatientswith_77_0.txt
_visibility_off_ Disable Animations
sense_dimmed_sleep/s41598023340024_246_32.txt
jI0LjMxLjQxLjY4LjUzIDEuMTEuMTMuNDIuMTkuOTEuMTkgMS40NCAwIC41OS0uMDkgMS4xMS0uMjUgMS41Ny0uMTYuNDctLjM4Ljg1LS42NSAxLjE2LS4yNy4zMi0uNTguNTYtLjk0LjczLS4zNS4xNi0uNzIuMj
sense_dimmed_sleep/s12931022021413_308_0.txt
26. Zinchuk AV, Gentry MJ, Concato J, Yaggi HK. Phenotypes in obstructive sleep apnea: a definition, examples and evolution of approaches. Sleep Med Rev. 2017;35:113–23. [ https://doi.org/10.1016/j.smrv.2016.10.002 ](https://doi.org/10.1016/j.smrv.2016.10.002).
sense_dimmed_sleep/s41598023340024_124_0.txt
\(2017\)."). Nevertheless, the major predictor of CPAP use was the interaction between obesity and low AT, not any of these variables alone [ 16 ](/articles/s41598-023-34002-4#ref-CR16 "Gray, E. L., McKenzie, D. K. & Eckert, D. J. Obstructive sleep apnea without obesity is common and difficult to treat: Evidence for a...
sense_dimmed_sleep/s41598023340024_303_0.txt
Email address
sense_dimmed_sleep/s41598023340024_246_49.txt
jM0LTEuMjgtLjIzLS4zMS0uNTgtLjQ3LTEuMDYtLjQ3LS40MSAwLS43Ny4xNS0xLjA4LjQ1LS4zMS4yOS0uNS43My0uNTcgMS4zem0zLjAxIDIuMjNjLjMxLjI0LjYxLjQzLjkyLjU3LjMuMTMuNj
sense_dimmed_sleep/s12931022021413_429_0.txt
### Competing interests
sense_dimmed_sleep/s12931022021413_305_0.txt
[ Article ](https://doi.org/10.1016%2Fj.smrv.2013.01.005) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23669094) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Supine%20position%20related%20obstructive%20sleep%
sense_dimmed_sleep/s41598023340024_222_0.txt
You can also search for this author in [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Carlos%20R.%20R.%20Carvalho) [ Google Scholar ](http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_
sense_dimmed_sleep/therelationshipbetwe_41_0.txt
[ Parenting Support ](https://www.thecenterforconnection.org/parenting- support)
sense_dimmed_sleep/s12931022021413_279_0.txt
[ Article ](https://link.springer.com/doi/10.1007/s11325-017-1499-0) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=28425082) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Discriminating%20between%20positional%20and%20
sense_dimmed_sleep/s12931022021413_179_0.txt
.") ]. As OSA severity exhibits a considerable night-to-night variability, the sleep position that determines the phenotype of POSA might show similar variability. Recording the sleeping position for several consecutive nights may be necessary to confirm the POSA phenotype. Nonetheless, this study adds to the literatur...
sense_dimmed_sleep/nonobesepatientswith_72_6.txt
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sense_dimmed_sleep/s12931022021413_282_0.txt
13. Mo JH, Lee CH, Rhee CS, Yoon IY, Kim JW. Positional dependency in Asian patients with obstructive sleep apnea and its implication for hypertension. Arch Otolaryngol Head Neck Surg. 2011;137(8):786–90. [ https://doi.org/10.1001/archoto.2011.122 ](https://doi.org/10.1001/archoto.2011.122).
sense_dimmed_sleep/s12931022021413_211_0.txt
EDS:
sense_dimmed_sleep/s12931022021413_122_0.txt
A low ArTH was more common in females than males (Table [ 1 ](/articles/10.1186/s12931-022-02141-3#Tab1) and Table [ 2 ](/articles/10.1186/s12931-022-02141-3#Tab2) ). The POSA group had a higher absolute fraction of hypopneas. The percentages of AHI < 30 events/h, LSaO 2 > 82.5%, and hypopnea proportion > 58.3%, were ...
sense_dimmed_sleep/s12931022021413_443_39.txt
3LS41MS0uMDUtLjE2LS4xMi0uMy0uMjItLjQzcy0uMjItLjIyLS4zOC0uM2MtLjE1LS4wNi0uMzQtLjEtLjU4LS4xLS4zNCAwLS42OC4wNy0xIC4ycy0uNjMuMjktLjkzLjQ3bC0uNTktMS4wOGMuMz
sense_dimmed_sleep/therelationshipbetwe_66_0.txt
o He/She may be over-responsive to tactile input
sense_dimmed_sleep/therelationshipbetwe_76_0.txt
o Try moving the bed to a corner, buying a body pillow
sense_dimmed_sleep/s12931022021413_156_0.txt
.") ]. Strategies to increase the ArTH have the potential to make breathing more stable during sleep. Previous studies showed that increasing the ArTH through pharmacological interventions can reduce OSA severity, particularly in patients with a low initial ArTH [ [ 50 ](/articles/10.1186/s12931-022-02141-3#ref-CR50 "E...
sense_dimmed_sleep/s41598023340024_79_0.txt
**Table 1 Anthropometric and clinical characteristics of study population.**
sense_dimmed_sleep/s41598023340024_73_1.txt
103 participants out of the entire group of 490 participants with COMISA and OSA-only.
sense_dimmed_sleep/s12931022021413_3_0.txt
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sense_dimmed_sleep/s41598023340024_32_0.txt
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sense_dimmed_sleep/s12931022021413_136_0.txt
."), [ 10 ](/articles/10.1186/s12931-022-02141-3#ref-CR10 "Lee SA, Paek JH, Chung YS, Kim WS. Clinical features in patients with positional obstructive sleep apnea according to its subtypes. Sleep Breath. 2017;21\(1\):109–17. https://doi.org/10.1007/s11325-016-1379-z
sense_dimmed_sleep/s12931022021413_446_0.txt
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sense_dimmed_sleep/s41598023340024_113_0.txt
\(2005\)."), [ 8 ](/articles/s41598-023-34002-4#ref-CR8 "Björnsdóttir, E. et al. Symptoms of insomnia among patients with obstructive sleep apnea before and after two years of positive airway pressure treatment. Sleep 36\(12\), 1901–1909. https://doi.org/10.5665/sleep.3226
sense_dimmed_sleep/s41598023340024_210_0.txt
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sense_dimmed_sleep/s41598023340024_63_0.txt
Daytime sleepiness was evaluated with the Epworth Sleepiness Scale (ESS). The ESS assesses the likelihood of falling asleep during eight common daily situations, with higher scores indicating greater sleepiness. An ESS ≥ 11 was used to define excessive daytime sleepiness [ 14 ](/articles/s41598-023-34002-4#ref-CR14 "J...
sense_dimmed_sleep/s41598023340024_169_0.txt
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sense_dimmed_sleep/s41598023340024_22_0.txt
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sense_dimmed_sleep/s41598023340024_25_0.txt
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sense_dimmed_sleep/nonobesepatientswith_27_0.txt
2\. Eckert DJ, White DP, Jordan AS, Malhotra A, Wellman A. Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. _Am J Respir Crit Care Med_. 2013;188(8):996-1004. [ doi: 10.1164/rccm.201303-0448OC ](about:blank)
sense_dimmed_sleep/s41598023340024_175_0.txt
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sense_dimmed_sleep/s12931022021413_309_1.txt
nea%3A%20a%20definition%2C%20examples%20and%20evolution%20of%20approaches&journal=Sleep%20Med%20Rev&doi=10.1016%2Fj.smrv.2016.10.002&volume=35&pages=113-123&publication_year=2017&author=Zinchuk%2CAV&author=Gentry%2CMJ&author=Concato%2CJ&author=Yaggi%2CHK)
sense_dimmed_sleep/s41598023340024_231_1.txt
22Pedro%20R.%20Genta%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en)
sense_dimmed_sleep/s41598023340024_106_0.txt
\(2020\)."), [ 21 ](/articles/s41598-023-34002-4#ref-CR21 "Wu, H., Fang, F., Wu, C., Zhan, X. & Wei, Y. Low arousal threshold is associated with unfavorable shift of PAP compliance over time in patients with OSA. Sleep Breath. 25\(2\), 887–895. https://doi.org/10.1007/s11325-0-20-02197-9
sense_dimmed_sleep/s12931022021413_212_0.txt
Excessive daytime sleepiness
sense_dimmed_sleep/s12931022021413_443_27.txt
My0xLjE5LS42My0uNSAwLS45LjIxLTEuMTguNjMtLjI5LjQxLS40My45Ny0uNDMgMS42N3ptNi40OC0zLjQ0aDEuMzNsLjEyIDEuMjFoLjA1Yy4yNC0uNDQuNTQtLjc5Ljg4LTEuMDIuMzUtLjI0LjctLjM2
sense_dimmed_sleep/s12931022021413_73_0.txt
The CC criteria for POSA include a supine AHI at least double that of the non- supine position, and a sleep time in each position ≥ 30 min. If these criteria are not met, OSA is classified as NPOSA. [ [ 6 ](/articles/10.1186/s12931-022-02141-3#ref-CR6 "Cartwright RD. Effect of sleep position on sleep apnea severity. Sl...
sense_dimmed_sleep/s41598023340024_173_0.txt
[ Article ](https://doi.org/10.1093%2Fsleepadvances%2Fzpac029.052) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Obstructive%20sleep%20apnea%20is%20a%20distinct%20physiological%20phenotype%20in%20individuals%20with%20comorbid%20insomnia%20and%20sleep%20apnea%28COMISA%29&journal=
sense_dimmed_sleep/s12931022021413_441_0.txt
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sense_dimmed_sleep/nonobesepatientswith_13_0.txt
**Nonobese patients with OSA: looking at an unusual cause**
sense_dimmed_sleep/s12931022021413_350_0.txt
47. Younes M. Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders. J Appl Physiol. 2008;105(5):1389–405. [ https://doi.org/10.1152/japplphysiol.90408.2008 ](https://doi.org/10.1152/japplphysiol.90408.2008).
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sense_dimmed_sleep/s12931022021413_313_0.txt
[ Article ](https://doi.org/10.1164%2Frccm.200307-1023OC) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14684560) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Role%20of%20arousals%20in%20the%20path
sense_dimmed_sleep/therelationshipbetwe_63_2.txt
.
sense_dimmed_sleep/s12931022021413_181_1.txt
POSA.
sense_dimmed_sleep/therelationshipbetwe_79_0.txt
o Try sleeping under or on top of a bean bag, using a weighted blanket (7-10% of child’s body weight)
sense_dimmed_sleep/s12931022021413_353_0.txt
[ Article ](https://doi.org/10.1164%2Fajrccm.163.5.2007013) [ CAS ](/articles/cas-redirect/1:STN:280:DC%2BD3MzisFGruw%3D%3D) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11316657) [ Google Scholar
sense_dimmed_sleep/s12931022021413_325_2.txt
&author=Duran%20Carro%2CJ&author=Ullate%2CJ)
sense_dimmed_sleep/s41598023340024_246_21.txt
U5IDQuMDdoLTEuNzVsLTEuNzctMi45OC0xLjA4IDEuMjN2MS43NWgtMS41OHptMTMuNjkgMS4yN2MtLjI1LS4xMS0uNS0uMTctLjc1LS4xNy0uNTggMC0uODcuMzktLjg3IDEuMTZ2Ljc1aDEuMzR2MS4yN2gtMS4zNHY1L
sense_dimmed_sleep/s41598023340024_104_0.txt
\(2017\)."), [ 17 ](/articles/s41598-023-34002-4#ref-CR17 "Zinchuk, A. et al. Prevalence, associated clinical features, and impact on continuous positive airway pressure use of a low respiratory arousal threshold among male United States veterans with obstructive sleep apnea. J. Clin. Sleep Med. 14\(5\), 809–817. https...
sense_dimmed_sleep/s12931022021413_243_0.txt
SaO2:
sense_dimmed_sleep/s12931022021413_261_2.txt
author=Matheson%2CMC)
sense_dimmed_sleep/s12931022021413_97_0.txt
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sense_dimmed_sleep/s41598023340024_105_0.txt
\(2018\)."), [ 20 ](/articles/s41598-023-34002-4#ref-CR20 "Zinchuk, A. V. et al. Physiological traits and adherence to obstructive sleep apnea treatment in patients with stroke. Am. J. Respir. Crit. Care Med. 201\(12\), 1568–1572. https://doi.org/10.1164/rccm.201911-2203LE
sense_dimmed_sleep/s12931022021413_125_0.txt
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sense_dimmed_sleep/s41598023340024_116_0.txt
\(1993\).") and has been associated with insomnia severity as measured by the ISI [ 6 ](/articles/s41598-023-34002-4#ref-CR6 "Puzino, K. et al. Arousability as a trait predisposition to insomnia: Multidimensional structure and clinical utility of the Spanish and English versions of the arousal predisposition scale. Sl...
sense_dimmed_sleep/s12931022021413_159_0.txt
.") ]. This is supported by emerging evidence that compromised upper airway anatomy in Asians is predominantly due to a restriction caused by the craniofacial skeletal structure, whereas in African-Americans it is primarily due to enlargement of upper airway soft tissues in the setting of obesity as well as non-anatomi...
sense_dimmed_sleep/s12931022021413_292_0.txt
18. Joosten SA, Hamza K, Sands S, Turton A, Berger P, Hamilton G. Phenotypes of patients with mild to moderate obstructive sleep apnoea as confirmed by cluster analysis. Respirology. 2012;17(1):99–107. [ https://doi.org/10.1111/j.1440-1843.2011.02037.x ](https://doi.org/10.1111/j.1440-1843.2011.02037.x).
sense_dimmed_sleep/s12931022021413_9_0.txt
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sense_dimmed_sleep/s12931022021413_74_0.txt
https://doi.org/10.1093/sleep/7.2.110
sense_dimmed_sleep/s12931022021413_334_0.txt
39. Schmickl CN, Li Y, Orr JE, Jen R, Sands SA, Edwards BA, et al. Effect of venlafaxine on apnea-hypopnea index in patients with sleep apnea: a randomized. Double-Blind Crossover. Study Chest. 2020;158(2):765–75. [ https://doi.org/10.1016/j.chest.2020.02.074 ](https://doi.org/10.1016/j.chest.2020.02.074).
sense_dimmed_sleep/s12931022021413_443_5.txt
jU1LTEwLjE2LTEzLjU3LTcuMDMtMjEuNWwtNC45Mi0zLjExYy00Ljk1IDEwLjctMS4xOSAyMy40MiA4Ljc4IDI5LjcxIDkuOTcgNi4zIDIzLjA3IDQuMjIgMzAuNi00Ljg2eiIgZmlsbD0iIzljOWM5YyIvPjxw
sense_dimmed_sleep/s41598023340024_141_0.txt
[ Article ](https://doi.org/10.1164%2Frccm.201404-0718OC) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25321848) [ PubMed Central ](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315811) [ Google Scholar ](http://scholar.
sense_dimmed_sleep/s12931022021413_219_0.txt
LSaO2:
sense_dimmed_sleep/s12931022021413_220_0.txt
Lowest oxygen saturation
sense_dimmed_sleep/s12931022021413_1_0.txt
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sense_dimmed_sleep/s12931022021413_291_2.txt
639&publication_year=1997&author=Oksenberg%2CA&author=Silverberg%2CDS&author=Arons%2CE&author=Radwan%2CH)
sense_dimmed_sleep/s12931022021413_155_0.txt
https://doi.org/10.5664/jcsm.6394
sense_dimmed_sleep/s41598023340024_246_25.txt
MtLjY0LjU0LTEuMDQuNy0uODEuMjQtMS4yNC4yNC0uODQtLjA4LTEuMjMtLjI0LS43NC0uMzktMS4wNC0uN2MtLjMxLS4zMS0uNTUtLjY5LS43Mi0xLjEzLS4xOC0uNDUtLjI3LS45Ni0uMjctMS41M3pt
sense_dimmed_sleep/s41598023340024_257_0.txt
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sense_dimmed_sleep/nonobesepatientswith_72_7.txt
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sense_dimmed_sleep/s12931022021413_39_0.txt
.") ].
sense_dimmed_sleep/s41598023340024_24_1.txt
underwent a type 3 sleep study and answered the insomnia severity index (ISI) questionnaire and the Epworth sleepiness scale. Participants with an ISI score ≥ 15 were defined as having insomnia. Sleep apnea was defined as an apnea hypopnea index (AHI) ≥ 15 events/h. Low AT was determined using a previously validated s...
sense_dimmed_sleep/therelationshipbetwe_100_1.txt
1ME8QSBBJPR52R)
sense_dimmed_sleep/nonobesepatientswith_9_0.txt
**The Pathophysiology of OSA remains complex**
sense_dimmed_sleep/nonobesepatientswith_75_0.txt
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sense_dimmed_sleep/s12931022021413_218_0.txt
Homeostasis model assessment of insulin resistance
sense_dimmed_sleep/s12931022021413_457_0.txt
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sense_dimmed_sleep/s12931022021413_371_0.txt
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sense_dimmed_sleep/s41598023340024_156_0.txt
11. Eckert, D. J., Malhotra, A., Wellman, A. & White, D. P. Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold. _Sleep_ **37** (4), 811–819. [ https://doi.org/10.5665/sleep.3596 ](https://doi.org/10.5665/sleep.3596) (2014).
sense_dimmed_sleep/s41598023340024_167_2.txt
year=2017&author=Gray%2CEL&author=McKenzie%2CDK&author=Eckert%2CDJ)
sense_dimmed_sleep/s41598023340024_122_0.txt
\(2020\)."), [ 27 ](/articles/s41598-023-34002-4#ref-CR27 "Young, T., Peppard, P. E. & Taheri, S. Excess weight and sleep-disordered breathing. J. Appl. Physiol. 99\(4\), 1592–1599. https://doi.org/10.1152/japplphysiol.00587.2005
sense_dimmed_sleep/s12931022021413_109_0.txt
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sense_dimmed_sleep/s41598023340024_112_0.txt
https://doi.org/10.1159/000087668
sense_dimmed_sleep/s12931022021413_420_0.txt
### Contributions
sense_dimmed_sleep/s12931022021413_408_0.txt
7. Jianyin Zou
sense_dimmed_sleep/s12931022021413_443_25.txt
MtLjY0LjU0LTEuMDQuNy0uODEuMjQtMS4yNC4yNC0uODQtLjA4LTEuMjMtLjI0LS43NC0uMzktMS4wNC0uN2MtLjMxLS4zMS0uNTUtLjY5LS43Mi0xLjEzLS4xOC0uNDUtLjI3LS45Ni0uMjctMS41M3pt
sense_dimmed_sleep/s12931022021413_364_0.txt
54. McNicholas WT, Bonsignore MR, Lévy P, Ryan S. Mild obstructive sleep apnoea: clinical relevance and approaches to management. Lancet Respir Med. 2016;4(10):826–34. [ https://doi.org/10.1016/s2213-2600(16)30146-1 ](https://doi.org/10.1016/s2213-2600\(16\)30146-1).
sense_dimmed_sleep/therelationshipbetwe_101_0.txt
· Complains the room is too bright (even with the lights off)
sense_dimmed_sleep/s41598023340024_179_0.txt
[ Article ](https://doi.org/10.1136%2Fthx.2010.135848) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20805182) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Predictors%20of%20long- term%20compliance%20with%20