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sense_dimmed_sleep/s41598023340024_248_0.txt
Yanagimori, M., Fernandes, M.D., Garcia, M.L. _et al._ Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA). _Sci Rep_ **13**, 7638 (2023). https://doi.org/10.1038/s41598-023-34002-4
sense_dimmed_sleep/s12931022021413_415_0.txt
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sense_dimmed_sleep/s41598023340024_225_0.txt
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sense_dimmed_sleep/s12931022021413_119_2.txt
#Tab1) ] and APOC [Table [ 2 ](/articles/10.1186/s12931-022-02141-3#Tab2) ], respectively). As shown in Table [ 1 ](/articles/10.1186/s12931-022-02141-3#Tab1), the si-POSA group had a lower BMI than the sp-POSA group, and the BMI was lower in the APOC I group than the other APOC subgroups (Table [ 2 ](/articles/10
sense_dimmed_sleep/s12931022021413_443_53.txt
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sense_dimmed_sleep/s12931022021413_227_0.txt
NPOSA:
sense_dimmed_sleep/s41598023340024_101_0.txt
\(2022\)."). In another abstract, AT was lower among COMISA subjects [ 19 ](/articles/s41598-023-34002-4#ref-CR19 "Brooker, E. et al. Obstructive sleep apnea is a distinct physiological phenotype in individuals with comorbid insomnia and sleep apnea\(COMISA\). Sleep Adv. 3\(1\), A22. https://doi.org/10.1093/sleepadvan...
sense_dimmed_sleep/s41598023340024_153_1.txt
olar_lookup?&title=Clinical%20practice%20guideline%20for%20the%20pharmacologic%20treatment%20of%20chronic%20insomnia%20in%20adults&journal=J.%20Clin.%20Sleep.%20Med.&doi=10.5664%2Fjcsm.6470&volume=13&issue=5&pages=307-349&publication_year=2017&author=Sateia%2CM&author=Buysse%
sense_dimmed_sleep/s12931022021413_416_1.txt
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sense_dimmed_sleep/therelationshipbetwe_54_0.txt
by Dr. Jamie Chaves, OTD, OTR/L, SWC
sense_dimmed_sleep/therelationshipbetwe_14_0.txt
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sense_dimmed_sleep/s41598023340024_102_1.txt
809–817. https://doi.org/10.5664/jcsm.7112
sense_dimmed_sleep/s12931022021413_443_45.txt
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sense_dimmed_sleep/s12931022021413_299_0.txt
[ Article ](https://doi.org/10.5664%2Fjcsm.8496) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32807295) [ PubMed Central ](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446091) [ Google Scholar ](http://scholar.google.com/
sense_dimmed_sleep/therelationshipbetwe_64_0.txt
If your child…
sense_dimmed_sleep/s12931022021413_254_0.txt
Waist circumference
sense_dimmed_sleep/s41598023340024_55_0.txt
\(2021\)."). The purpose of the present study is to assess the AT among participants with COMISA and those with OSA only. We hypothesized that a low AT is more common among COMISA than among OSA patients without insomnia.
sense_dimmed_sleep/s12931022021413_443_7.txt
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sense_dimmed_sleep/nonobesepatientswith_46_5.txt
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sense_dimmed_sleep/s41598023340024_7_0.txt
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sense_dimmed_sleep/s41598023340024_246_17.txt
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sense_dimmed_sleep/s12931022021413_331_1.txt
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sense_dimmed_sleep/s12931022021413_370_0.txt
57. Stöberl AS, Schwarz EI, Haile SR, Turnbull CD, Rossi VA, Stradling JR, et al. Night-to-night variability of obstructive sleep apnea. J Sleep Res. 2017;26(6):782–8. [ https://doi.org/10.1111/jsr.12558 ](https://doi.org/10.1111/jsr.12558).
sense_dimmed_sleep/s41598023340024_246_55.txt
Ljk1LS4wOS0xLjQxLS4yNy0uNDYtLjE5LS44Ni0uNDEtMS4yLS42OHoiIGZpbGw9IiM1MzUzNTMiLz48L2c+PC9zdmc+) ](https://crossmark.crossref.org/dialog/?doi=10.1038/s41598-023-34002-4)
sense_dimmed_sleep/nonobesepatientswith_62_0.txt
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sense_dimmed_sleep/s12931022021413_263_2.txt
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sense_dimmed_sleep/s12931022021413_345_2.txt
92&issue=6&pages=843-848&publication_year=1998&author=Ong%2CKC&author=Clerk%2CAA)
sense_dimmed_sleep/s12931022021413_163_0.txt
.") ]. In one study, at least one-third of OSA patients had low ArTH levels [ [ 53 ](/articles/10.1186/s12931-022-02141-3#ref-CR53 "Eckert DJ. Phenotypic approaches to obstructive sleep apnoea—new pathways for targeted therapy. Sleep Med Rev. 2018;37:45–59. https://doi.org/10.1016/j.smrv.2016.12.003
sense_dimmed_sleep/nonobesepatientswith_23_1.txt
., non-myorelaxant sedatives) to increase the threshold for arousal, alone, or in combination with existing therapies (e.g., CPAP or oral appliances), may yield greater therapeutic success in this group of patients. 2 Improved understanding of the pathophysiology of OSA in recent years provides an opportunity to deve...
sense_dimmed_sleep/s12931022021413_337_0.txt
[ Article ](https://doi.org/10.1016%2Fj.sleep.2019.09.007) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32008889) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Reduced%20cortical%20arousability%20to%20noct
sense_dimmed_sleep/s12931022021413_297_1.txt
%20apnea%20in%20the%20HypnoLaus%20population- based%20cohort&journal=Sleep%20Med&doi=10.1016%2Fj.sleep.2018.02.011&volume=48&pages=157-162&publication_year=2018&author=Heinzer%2CR&author=Petitpierre%2CNJ&author=Marti- Soler%2CH&author=Haba-Rubio%2CJ)
sense_dimmed_sleep/s41598023340024_255_0.txt
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sense_dimmed_sleep/s12931022021413_195_0.txt
ArTH:
sense_dimmed_sleep/s12931022021413_88_0.txt
The sample size was determined based on power analysis. With a power of 90% and α of 0.05, 2,300 participants were required. The Kolmogorov–Smirnov test was used to verify the normality of the data distribution. Continuous variables with a normal distribution are shown as means ± standard deviation, while skewed data a...
sense_dimmed_sleep/s41598023340024_11_0.txt
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sense_dimmed_sleep/s12931022021413_309_0.txt
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sense_dimmed_sleep/s12931022021413_443_10.txt
zMy0xLjI2LS4zMy0yLjAyem04LjQtNS4zM2gxLjYxdjIuNTRsLS4wNSAxLjMzYy4yOS0uMjcuNjEtLjUxLjk2LS43MnMuNzYtLjMxIDEuMjQtLjMxYy43MyAwIDEuMjcuMjMgMS42MS43MS4zMy40Ny41
sense_dimmed_sleep/therelationshipbetwe_24_0.txt
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sense_dimmed_sleep/s12931022021413_36_0.txt
.") ]. There are currently about 176 million OSA patients in China, with about 66 million classified as moderate to severe [ [ 1 ](/articles/10.1186/s12931-022-02141-3#ref-CR1 "Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, et al. Estimation of the global prevalence and burden of obstructive sleep ...
sense_dimmed_sleep/therelationshipbetwe_115_0.txt
9) Lights out.
sense_dimmed_sleep/nonobesepatientswith_23_0.txt
The treatment of choice is continuous positive airway pressure (CPAP); however, **nonobese patients with OSA with a low arousal threshold have poorer adherence to CPAP therapy**. 8 CPAP may not be the right therapy for everyone. For some patients, other approaches such as mandibular advancement devices (MADs), maxill...
sense_dimmed_sleep/s41598023340024_111_0.txt
Middle insomnia is the most common insomnia subtype among COMISA participants [ 1 ](/articles/s41598-023-34002-4#ref-CR1 "Chung, K. F. Insomnia subtypes and their relationships to daytime sleepiness in patients with obstructive sleep apnea. Respiration 72\(5\), 460–465.
sense_dimmed_sleep/s41598023340024_246_5.txt
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sense_dimmed_sleep/s12931022021413_23_0.txt
To evaluate the prevalence, characteristics, and respiratory arousal threshold (ArTH) of Chinese patients with positional obstructive sleep apnea (POSA) according to the Cartwright Classification (CC) and Amsterdam Positional Obstructive Sleep Apnea Classification (APOC).
sense_dimmed_sleep/s12931022021413_323_1.txt
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sense_dimmed_sleep/s12931022021413_464_0.txt
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sense_dimmed_sleep/s12931022021413_113_0.txt
Chinese POSA patients had lower AHI, ODI, and CT90 values, and higher mean SaO 2 and LSaO 2 values, than NPOSA patients during sleep. The overall AHI, supine AHI, non-supine AHI, REM AHI, and NREM AHI values were lower in the POSA group (all _P_ < 0.001), indicating less severe OSA compared to the NPOSA group accord...
sense_dimmed_sleep/therelationshipbetwe_0_0.txt
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sense_dimmed_sleep/nonobesepatientswith_15_0.txt
**How prevalent is low arousal threshold?**
sense_dimmed_sleep/s12931022021413_267_0.txt
[ Article ](https://doi.org/10.1001%2Fjama.2020.3514) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32286648) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Diagnosis%20and%20management%20of%20obstructive%20sleep%20
sense_dimmed_sleep/s12931022021413_154_1.txt
2017;13\(1\):81–8.
sense_dimmed_sleep/s12931022021413_448_0.txt
* Accepted : 16 August 2022
sense_dimmed_sleep/s41598023340024_246_35.txt
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sense_dimmed_sleep/s12931022021413_4_0.txt
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sense_dimmed_sleep/s12931022021413_183_0.txt
There is strong evidence that the severity of obstructive sleep apnea (OSA) can worsen when sleeping in the supine position, which is known as positional OSA (POSA). While POSA is prevalent among adults, there are limited data on the presence and characteristics of POSA in China. In addition, studies of large clinical ...
sense_dimmed_sleep/nonobesepatientswith_24_0.txt
The study authors believe that further pathophysiologic studies are needed to better clarify the role of low arousal threshold in patients with OSA and in the nonobese subgroup.
sense_dimmed_sleep/s12931022021413_295_1.txt
%20of%20positional%20sleep%20apnea%20and%20its%20predictors&journal=Sleep%20Breath&doi=10.1007%2Fs11325-011-0627-5&volume=16&issue=4&pages=1167-1172&publication_year=2012&author=Teerapraipruk%2CB&author=Chirakalwasan%2CN&author=Simon%2CR&author=Hirunwiwatkul%2CP
sense_dimmed_sleep/s12931022021413_122_1.txt
POSA than NPOSA group, and higher in the si-POSA than sp-POSA group. In the si-POSA and sp- POSA groups, the proportions of low ArTH (71.13% and 31.86%, respectively) were significantly higher compared to the NPOSA group (22.85%) (Table [ 1 ](/articles/10.1186/s12931-022-02141-3#Tab1) ). The APOC I group had the highe...
sense_dimmed_sleep/s41598023340024_33_0.txt
### [ A novel parameter is better than the AHI to assess nocturnal hypoxaemia and excessive daytime sleepiness in obstructive sleep apnoea ](https://www.nature.com/articles/s41598-021-84239-0?fromPaywallRec=false)
sense_dimmed_sleep/s41598023340024_3_2.txt
%3D1785,476,692,699%26kwrd%3DDiseases,Psychiatric+disorders,Respiratory+tract+diseases)
sense_dimmed_sleep/s12931022021413_82_0.txt
Edwards et al. established a clinical screening tool for low ArTH based on three criteria: AHI < 30/h, LSaO 2 > 82.5%, and proportion of hypopneas > 58.3% [ [ 38 ](/articles/10.1186/s12931-022-02141-3#ref-CR38 "Edwards BA, Eckert DJ, McSharry DG, Sands SA, Desai A, Kehlmann G, et al. Clinical predictors of the respir...
sense_dimmed_sleep/s41598023340024_145_2.txt
%20Res.%20Ther.&doi=10.1016%2F0005-7967%2888%2990076-9&volume=26&issue=5&pages=415-420&publication_year=1988&author=Coren%2CS)
sense_dimmed_sleep/s41598023340024_187_0.txt
[ Article ](https://link.springer.com/doi/10.1007/s11325-020-02235-6) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=33123927) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Clinical%20characteristics%20of%20Asian%20pat
sense_dimmed_sleep/s12931022021413_143_1.txt
737–46. https://doi.org/10.1378/chest.15-0638
sense_dimmed_sleep/s41598023340024_153_2.txt
2CD&author=Krystal%2CAD&author=Neubauer%2CD&author=Heald%2CJ)
sense_dimmed_sleep/s12931022021413_223_0.txt
MS:
sense_dimmed_sleep/s12931022021413_341_0.txt
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sense_dimmed_sleep/s12931022021413_469_0.txt
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sense_dimmed_sleep/s41598023340024_246_44.txt
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sense_dimmed_sleep/nonobesepatientswith_8_0.txt
Obstructive sleep apnea (OSA) is well-established as a disease that is also a risk factor for many other health problems. Studies continue to help increase understanding of why people develop sleep apnea, which people are more susceptible, when to test for it, how to treat it properly, and so forth. A recent study adde...
sense_dimmed_sleep/s12931022021413_329_0.txt
[ Article ](https://doi.org/10.1136%2Fthoraxjnl-2015-207403) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26883674) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Distinct%20severity%20stages%20of%20obstruct
sense_dimmed_sleep/s41598023340024_157_0.txt
[ Article ](https://doi.org/10.5665%2Fsleep.3596) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24899767) [ PubMed Central ](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044741) [ Google Scholar ](http://scholar.google.com/scholar
sense_dimmed_sleep/s41598023340024_161_0.txt
[ Article ](https://doi.org/10.1111%2Fjsr.13198) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32997368) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=The%20European%20Portuguese%20version%20of%20the%20insomnia%20
sense_dimmed_sleep/s12931022021413_443_4.txt
zAgNC43MS0xLjg3IDkuMjItNS4yIDEyLjU1cy03Ljg0IDUuMi0xMi41NSA1LjJ6IiBmaWxsPSIjNTM1MzUzIi8+PHBhdGggZD0ibTQxIDM2Yy01LjgxIDYuMjMtMTUuMjMgNy40NS0yMi40MyAyLjktNy4yMS00L
sense_dimmed_sleep/s12931022021413_471_0.txt
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sense_dimmed_sleep/s12931022021413_145_0.txt
In POSA, respiratory events generally cease, accompanied by cortical arousal. Respiratory arousal during sleep can prevent apnea and may even be lifesaving [ [ 41 ](/articles/10.1186/s12931-022-02141-3#ref-CR41 "Lee RWW, Sutherland K, Sands SA, Edwards BA, Chan TO, et al. Differences in respiratory arousal threshold in...
sense_dimmed_sleep/s12931022021413_229_0.txt
NREM:
sense_dimmed_sleep/s41598023340024_273_0.txt
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sense_dimmed_sleep/therelationshipbetwe_94_0.txt
o Try only giving chewy or crunchy foods before bedtime and/or at dinner
sense_dimmed_sleep/s12931022021413_355_1.txt
olar_lookup?&title=Obstructive%20sleep%20apnea%20without%20obesity%20is%20common%20and%20difficult%20to%20treat%3A%20evidence%20for%20a%20distinct%20pathophysiological%20phenotype&journal=J%20Clin%20Sleep%20Med&doi=10.5664%2Fjcsm.6394&volume=13&issue=1&pages=81-88&publication_year=2017
sense_dimmed_sleep/therelationshipbetwe_108_0.txt
2) Play hard for about 45 minutes before you start the quiet bedtime routine.
sense_dimmed_sleep/s41598023340024_176_0.txt
21. Wu, H., Fang, F., Wu, C., Zhan, X. & Wei, Y. Low arousal threshold is associated with unfavorable shift of PAP compliance over time in patients with OSA. _Sleep Breath._ **25** (2), 887–895. [ https://doi.org/10.1007/s11325-0-20-02197-9 ](https://doi.org/10.1007/s11325-0-20-02197-9) (2020).
sense_dimmed_sleep/s12931022021413_180_0.txt
## Conclusion
sense_dimmed_sleep/s12931022021413_327_1.txt
olar_lookup?&title=Rules%20for%20scoring%20respiratory%20events%20in%20sleep%3A%20update%20of%20the%202007%20AASM%20manual%20for%20the%20scoring%20of%20sleep%20and%20associated%20events.%20Deliberations%20of%20the%20sleep%20apnea%20definitions%20task%20force%20of%20the%20American%20Academy
sense_dimmed_sleep/s12931022021413_88_1.txt
and the χ 2 test. Logistic regression analyses were performed to identify predictors of POSA, and the association between ArTH and POSA. Age, BMI, sex, NC, WC, HC, alcohol consumption, smoking, TST, ESS, MAI, and CT90 were included as potential confounding factors. Statistical analyses were performed using SPSS soft...
sense_dimmed_sleep/s12931022021413_341_1.txt
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sense_dimmed_sleep/s12931022021413_28_0.txt
### Conclusions
sense_dimmed_sleep/s41598023340024_270_0.txt
## Publish with us
sense_dimmed_sleep/s41598023340024_208_0.txt
1. Marcela Yanagimori
sense_dimmed_sleep/s12931022021413_443_20.txt
LjE2LS43NS0uMzktMS4wNS0uN3MtLjUzLS42OS0uNy0xLjEzYy0uMTctLjQ1LS4yNS0uOTYtLjI1LTEuNTN6bTYuOTEtNi40NWgxLjU4djYuMTdoLjA1bDIuNTQtMy4xNmgxLjc3bC0yLjM1IDIuOCAyLj
sense_dimmed_sleep/therelationshipbetwe_109_0.txt
3) Transition to the calming routine by dimming the lights and playing classical instrumental music.
sense_dimmed_sleep/therelationshipbetwe_124_0.txt
[ CFC Events and Groups ](/cfc-events-and-groups)
sense_dimmed_sleep/s12931022021413_443_15.txt
4LTEuMzQtLjI1LS40MS0uMTYtLjc2LS40LTEuMDctLjctLjMxLS4zMS0uNTUtLjY5LS43Mi0xLjEzLS4xOC0uNDQtLjI2LS45NS0uMjYtMS41MnptNC42LS42MmMwLS41NS0uMTEtLjk4LS4zNC0xLjI4LS4yMy0
sense_dimmed_sleep/s12931022021413_127_3.txt
CI, 2.673–4.325; adjusted OR, 5.127; 95% CI, 4.121–6.379; and adjusted OR, 3.399; 95% CI, 2.822–4.095, respectively) (Table [ 5 ](/articles/10.1186/s12931-022-02141-3#Tab5) ). After adjusting for potential confounders, OSA patients with a mean SaO 2 > 95% were 49.5% (OR, 1.495 [95%
sense_dimmed_sleep/Parietal_lobe_2.txt
Function[edit] Functions of the parietal lobe include: Two point discrimination – through touch alone without other sensory input (e.g. visual) Graphesthesia – recognizing writing on skin by touch alone Touch localization (bilateral simultaneous stimulation) The parietal lobe plays important roles in integrating sensor...
sense_dimmed_sleep/s12931022021413_207_0.txt
CT90:
sense_dimmed_sleep/s12931022021413_425_0.txt
### Ethics approval and consent to participate
sense_dimmed_sleep/s12931022021413_363_0.txt
[ Article ](https://doi.org/10.1016%2Fj.smrv.2016.12.003) [ PubMed ](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=28110857) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Phenotypic%20approaches%20to%20obstructive%
sense_dimmed_sleep/s41598023340024_185_0.txt
[ Article ](https://doi.org/10.1177%2F0033294117742654) [ Google Scholar ](http://scholar.google.com/scholar_lookup?&title=Portuguese%20version%20of%20the%20arousal%20predisposition%20scale%3A%20Preliminary%20evidence%20for%20a%20two- factor%20structure%20in%20a%20nonclinical%20sample&journal=Psychol.%
sense_dimmed_sleep/s12931022021413_5_0.txt
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