text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
four patients are presented who sustained blunt trauma and later developed necrotizing fasciitis in the areas of contusion , associated with the distant locus of sepsis . | NA | {
"id": "C0043253",
"name": "blunt trauma",
"pos": [
42,
54
]
} | {
"id": "C0009938",
"name": "contusion",
"pos": [
113,
122
]
} |
urate crystalluria was controlled by allopurinol therapy but renal calculi developed , which contained a variety of purines , particularly the relatively insoluble xanthine , as well as oxypurinol and hypoxanthine . | NA | {
"id": "C0002144",
"name": "allopurinol",
"pos": [
37,
48
]
} | {
"id": "C0034140",
"name": "purines",
"pos": [
116,
123
]
} |
5 ) two peaks of vt occurrence , on the first day and in the 4th week after the onset of ami , were recognized especially in anterior infarction group ; | NA | {
"id": "C0027051",
"name": "ami",
"pos": [
89,
92
]
} | {
"id": "C0340293",
"name": "anterior infarction",
"pos": [
125,
144
]
} |
the other showed marked accumulation of tetraploid cells almost without dna synthetic cells , being composed of relatively uniform fibroblastic or stellate-like cells in the cartilaginous matrix . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
51,
56
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
131,
143
]
} |
some kinds of amino acid , alanine , valin , glycine , and so on were recognized in d-mice tumors at higher levels more than in n-mice . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
14,
24
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
27,
34
]
} |
some kinds of amino acid , alanine , valin , glycine , and so on were recognized in d-mice tumors at higher levels more than in n-mice . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
14,
24
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
45,
52
]
} |
according to the new classification proposed by the lymphoma study group of japan ( lsg ) , there were 226 patients with non-hodgkin 's lymphoma ( nhl ) which was further classified as diffuse lymphoma ( 216 cases ) , follicular lymphoma ( 4 cases ) , mycosis fungoides ( 4 cases ) , and others ( 2 cases ) . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
121,
144
]
} | {
"id": "C0024301",
"name": "follicular lymphoma",
"pos": [
218,
237
]
} |
in the presence or absence of carbon dioxide , cyclic amp and dibutyryl cyclic amp had no effect on hydrogen ion secretion in fasted turtles . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
47,
57
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic",
"pos": [
62,
78
]
} |
protein excretion increased throughout pregnancy and by the third trimester in healthy women averaged 200 mg in 24 hr and regularly exceeded 500 mg in 24 hr in transplant patients , which was three times non-pregnant levels and probably not clinically significant . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
39,
48
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
60,
75
]
} |
low-molecular-weight ( lmw ) heparin has been compared to standard unfractionated ( uf ) heparin in a total of 49 patients on hemodialysis and hemofiltration in order to determine the necessary therapeutic dose and its effect on the coagulation system . | NA | {
"id": "C0019139",
"name": "low-molecular-weight",
"pos": [
0,
20
]
} | {
"id": "C0019134",
"name": "unfractionated",
"pos": [
67,
81
]
} |
a lmw heparin dose corresponding to 50 % of the normal uf heparin dose was found to produce similar plasma heparin levels ( anti-fxa-u/ml ) in particular on minimal heparinization . | NA | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
2,
13
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
165,
172
]
} |
at higher doses , uf heparin produced a more marked increase in plasma-heparin than did lmw heparin . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
21,
28
]
} | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
88,
99
]
} |
partial thromboplastin time ( ptt ) increased under uf heparin by an average of 120 s whereas lmw heparin only produced an increase of 5-7 s . | NA | {
"id": "C0019134",
"name": "uf heparin",
"pos": [
52,
62
]
} | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
94,
105
]
} |
thrombin time was increased by 250-280 s under uf heparin and by 5-8 s under lmw heparin . | NA | {
"id": "C0019134",
"name": "uf heparin",
"pos": [
47,
57
]
} | {
"id": "C0019139",
"name": "lmw",
"pos": [
77,
80
]
} |
additional chloride intake , such as supplemental potassium chloride , interfered with estimates of salt ingestion , but if the daily amount of potassium chloride supplement was constant , adjustments in interpretation could be made . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
11,
19
]
} | {
"id": "C0032825",
"name": "potassium chloride",
"pos": [
144,
162
]
} |
inhibition of binding for catecholamines in the following order of potency : l-isoprenaline greater than l-adrenaline greater than l-noradrenaline proves the bs as a beta 2-receptor subtype . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
26,
40
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
79,
91
]
} |
inhibition of binding for catecholamines in the following order of potency : l-isoprenaline greater than l-adrenaline greater than l-noradrenaline proves the bs as a beta 2-receptor subtype . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
107,
117
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
133,
146
]
} |
two of the eight patients with suppressed trh-tsh tests were clinically hyperthyroid , in four others thyrotoxicosis developed within 1 to 2 1/2 months after the first observation of a suppressed tsh response , while two patients remained euthyroid . | NA | {
"id": "C0020550",
"name": "hyperthyroid",
"pos": [
72,
84
]
} | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
102,
116
]
} |
six subjects progressed into obvious cs , while in two hypercortisolism spontaneously regressed and in one it remained unchanged . | NA | {
"id": "C0010481",
"name": "cs",
"pos": [
37,
39
]
} | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
55,
71
]
} |
selected serum enzymes , cholesterol , triglycerides , glucose , uric acid , protein , albumin , bilirubin , bun , hematology , and electrocardiograms ( ekg ) were obtained from adult male cynomolgus ( macaca fascicularis ) and adult male stumptailed ( macaca arctoides ) macaques . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
77,
84
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
87,
94
]
} |
protein turnover in cardiac and skeletal muscle is affected by the provision of amino acids , particularly the branched chain amino acids ( bcaa ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
80,
91
]
} | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
111,
137
]
} |
the effect of each of the bcaa , valine , leucine , and isoleucine , on the systolic function of isolated normal or septic rat heart perfused as a langendorff preparation was examined . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
26,
30
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
33,
39
]
} |
the effect of each of the bcaa , valine , leucine , and isoleucine , on the systolic function of isolated normal or septic rat heart perfused as a langendorff preparation was examined . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
26,
30
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
59,
66
]
} |
the effect of each of the bcaa , valine , leucine , and isoleucine , on the systolic function of isolated normal or septic rat heart perfused as a langendorff preparation was examined . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
26,
30
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
56,
66
]
} |
none of these antibodies could be considered suitable for use in a testosterone immunoassay , but it does suggest that an antibody with an improved specificity profile could be found using the monoclonal antibody approach . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
14,
24
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
193,
212
]
} |
no activity was observed with the proopiomelanocortin-derived peptides in either zone , with the exception of beta-lph and alpha-msh . | NA | {
"id": "C0033195",
"name": "proopiomelanocortin",
"pos": [
34,
53
]
} | {
"id": "C0023832",
"name": "beta-lph",
"pos": [
110,
118
]
} |
after 5 days in culture before addition of acth , the main products of the metabolism of doc were corticosterone and 18-hydroxy-11-deoxycorticosterone in a 2:1 ratio . | NA | {
"id": "C0011710",
"name": "doc",
"pos": [
89,
92
]
} | {
"id": "C0000173",
"name": "18-hydroxy-11-deoxycorticosterone",
"pos": [
117,
150
]
} |
we have recently reported that bovine adrenocortical cytochrome p-45011 beta catalyzes 19-hydroxylation of 18-hydroxy-11-deoxycorticosterone ( 18 ( oh ) doc ) in addition to 11 beta-hydroxylation of the steroid . | NA | {
"id": "C0000173",
"name": "18-hydroxy-11-deoxycorticosterone",
"pos": [
107,
140
]
} | {
"id": "C0011710",
"name": "doc",
"pos": [
153,
156
]
} |
thus , ketanserin coadministration is not likely to alter steady-state concentrations of digoxin or digitoxin during clinical use of these two digitalis glycosides . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
89,
96
]
} | {
"id": "C0012253",
"name": "digitalis glycosides",
"pos": [
143,
163
]
} |
thus , ketanserin coadministration is not likely to alter steady-state concentrations of digoxin or digitoxin during clinical use of these two digitalis glycosides . | NA | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
100,
109
]
} | {
"id": "C0012253",
"name": "digitalis glycosides",
"pos": [
143,
163
]
} |
the antihypertensive effects of captopril and enalapril maleate were studied over a 10-week period in 24 hypertensive patients randomized into captopril or enalapril treatment groups . | NA | {
"id": "C0700452",
"name": "enalapril maleate",
"pos": [
46,
63
]
} | {
"id": "C0014025",
"name": "enalapril",
"pos": [
156,
165
]
} |
the local concentration of l-5-hydroxy-tryptophan ( 5-htp ) in isf from the antrum was determined in conscious rats after intraperitoneal loading with 5-htp . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
39,
49
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
151,
156
]
} |
the sensitivity of nontransformed t and b cells to lt indicates that this lymphokine may play an immunoregulatory role . | NA | {
"id": "C0024320",
"name": "lt",
"pos": [
51,
53
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
74,
84
]
} |
whether the ia+ subpopulation of m-csf responsive progenitor cells represents precursors for a separate cell lineage or a subclass of macrophages remains to be determined . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
3,
6
]
} | {
"id": "C0018956",
"name": "precursors",
"pos": [
78,
88
]
} |
the basic level of luminol dependent chemiluminescence ( ldcl ) was increased , whereas the basal value of reduced/oxidized glutathione ( gsh per gs-sg ) was decreased in the aged groups . | NA | {
"id": "C0061516",
"name": "oxidized glutathione",
"pos": [
115,
135
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
138,
141
]
} |
these decreases in gsh peroxidase and gssg reductase do not account for the lower gsh levels in aging . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
38,
42
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
82,
85
]
} |
decreases in cellular excitability produced by gabaergic stimulation leads to control of seizures in practically all animal models of epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
89,
97
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
134,
142
]
} |
randomised trial of intravenous recombinant tissue-type plasminogen activator versus intravenous streptokinase in acute myocardial infarction . | NA | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
56,
77
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
97,
110
]
} |
in the rt-pa group only 4.5 % of the fibrinogen was measured as incoagulable fibrinogen degradation products , compared with 30 % in the streptokinase group . | NA | {
"id": "C0032144",
"name": "rt-pa",
"pos": [
7,
12
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
137,
150
]
} |
since other neuropeptides , including somatostatin , human pancreatic growth hormone releasing factor ( hpgrf ) , substance p , bombesin , and neurotensin , had no demonstrable effects on gastric mucosa , we can conclude that the lesions were not a general effect of intracisternal administration of neuropeptides . | NA | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
143,
154
]
} | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
300,
313
]
} |
intracerebroventricular ( icv ) injection of dn1417 ( 0.3 , 3 and 30 nmol/rat ) , a trh analog , resulted in a dose-related increase in plasma glucose , epinephrine and norepinephrine levels in conscious male rats . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
153,
164
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
169,
183
]
} |
intravenous injection of dn1417 ( 30 nmol/rat ) did not change plasma glucose , epinephrine and norepinephrine levels . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
80,
91
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
96,
110
]
} |
dn1417 did not change plasma glucose , epinephrine and norepinephrine levels in rats after total adrenalectomy . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
39,
50
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
55,
69
]
} |
in the animals pretreated with cysteamine ( 30 mg/100 g body wt , sc , 4 h before ) , basal plasma glucose , epinephrine and norepinephrine levels were raised , and exaggerated responses of plasma glucose , epinephrine and norepinephrine to dn1417 ( 3 nmol/rat , icv ) were obtained . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
109,
120
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
223,
237
]
} |
alterations in plasma gonadotropins may be mediated by cannabinoid effects on catecholamine concentrations in median eminence and thc-induced alterations in testicular responsiveness to gonadotropin probably also involve direct effects of thc at the gonadal level . | NA | {
"id": "C0006864",
"name": "cannabinoid",
"pos": [
55,
66
]
} | {
"id": "C0039663",
"name": "thc",
"pos": [
239,
242
]
} |
beta-funaltrexamine ( beta-fna ) was tested in the spinal cord and supraspinally against inhibition of reflex bladder contractions produced in the anesthetized rat by the opioid-receptor selective agonists [ d-ala2 , mephe4 , gly ( ol ) 5 ] enkephalin ( dago , mu-agonist ) and [ d-pen2 , d-pen5 ] enkephalin ( dpdpe , d... | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
254,
258
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
298,
308
]
} |
beta-funaltrexamine ( beta-fna ) was tested in the spinal cord and supraspinally against inhibition of reflex bladder contractions produced in the anesthetized rat by the opioid-receptor selective agonists [ d-ala2 , mephe4 , gly ( ol ) 5 ] enkephalin ( dago , mu-agonist ) and [ d-pen2 , d-pen5 ] enkephalin ( dpdpe , d... | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
241,
251
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
311,
316
]
} |
female c57bl/6j mice were maintained on a choline-deficient chow and on drinking water supplemented with either 0 , 1.5 , or 4.0 mg/ml choline chloride from 8 to 20 months of age . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
42,
49
]
} | {
"id": "C0008409",
"name": "choline chloride",
"pos": [
135,
151
]
} |
in competition binding experiments , binding was shown to be stereoselective , and rank ordering of affinities of dopaminergic and non-dopaminergic compounds closely correlated with potencies of these compounds in stimulating or inhibiting dopamine-sensitive adenylate cyclase ( d-1 ) and in binding to d-1 sites labelle... | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
114,
126
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
240,
248
]
} |
the novel dihydropyridine bay k8644 enhanced depolarization-induced 45ca2+ uptake into each cell line in a nitrendipine reversible fashion . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
10,
25
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
107,
119
]
} |
to evaluate any direct action of avp on pituitary hormone secretion , the peptide was incubated with dispersed anterior pituitary cells for 2 hours . | NA | {
"id": "C0032015",
"name": "pituitary hormone",
"pos": [
40,
57
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
111,
129
]
} |
an unknown pl containing sphingosine , choline and vicinal hydroxyl groups but no free amino moieties made up approximately 19 % of the pl of sm and whole cells , but it constituted approximately 27 % of the pl of km . | NA | {
"id": "C0031676",
"name": "pl",
"pos": [
11,
13
]
} | {
"id": "C0771648",
"name": "of",
"pos": [
211,
213
]
} |
the results of treatment of 230 patients with different malignant tumors of the greater salivary glands ( adenocystic carcinoma , adenocarcinoma , mucoepidermoid tumor , undifferentiated carcinoma , carcinoma in pleomorphous adenoma , epidermoid carcinoma , etc . ) were analysed . | NA | {
"id": "C0010606",
"name": "adenocystic carcinoma",
"pos": [
106,
127
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
130,
144
]
} |
in radiation therapy used as a single modality the 5-year survival rates were 38.8 % in adenocystic carcinoma and 8.3 % in adenocarcinoma . | NA | {
"id": "C0010606",
"name": "adenocystic carcinoma",
"pos": [
88,
109
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
123,
137
]
} |
the overall lipid and protein composition of the hdl lipoproteins was similar before and during treatment . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
12,
17
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
53,
65
]
} |
follow-up ldl-c/hdl-c was related both to change in height ( negatively ) and to change in weight ( positively ) , after controlling for year 1 ldl-c/hdl-c . | NA | {
"id": "C0023824",
"name": "ldl-c",
"pos": [
10,
15
]
} | {
"id": "C0008377",
"name": "ldl-c",
"pos": [
144,
149
]
} |
follow-up ldl-c/hdl-c was related both to change in height ( negatively ) and to change in weight ( positively ) , after controlling for year 1 ldl-c/hdl-c . | NA | {
"id": "C0023822",
"name": "ldl-c/hdl-c",
"pos": [
10,
21
]
} | {
"id": "C0008377",
"name": "ldl-c",
"pos": [
144,
149
]
} |
insulin responses to oral glucose loads were studied in patients with obstructive jaundice and compared with those of other liver diseases ( fatty liver , chronic hepatitis and liver cirrhosis ) , pancreatic diseases , and definite diabetes mellitus . | NA | {
"id": "C0023895",
"name": "of",
"pos": [
115,
117
]
} | {
"id": "C0015695",
"name": "fatty",
"pos": [
141,
146
]
} |
insulin responses to oral glucose loads were studied in patients with obstructive jaundice and compared with those of other liver diseases ( fatty liver , chronic hepatitis and liver cirrhosis ) , pancreatic diseases , and definite diabetes mellitus . | NA | {
"id": "C0023895",
"name": "of",
"pos": [
115,
117
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
177,
192
]
} |
the grades of each tissue reaction in cases without lymphatic node metastasis were higher than that observed in cases with metastasis . | NA | {
"id": "C0024232",
"name": "lymphatic",
"pos": [
52,
61
]
} | {
"id": "C0027627",
"name": "metastasis",
"pos": [
123,
133
]
} |
coproporphyrin was the major porphyrin to accumulate in response to the 4-isopropyl analogue and uro- and heptacarboxylic acid porphyrins in response to the 4-benzyl analogue . | NA | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
0,
14
]
} | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
127,
136
]
} |
in rat pancreatic islets , the apparent space of distribution of galactose is not different from that of other hexoses . | NA | {
"id": "C0016945",
"name": "galactose",
"pos": [
65,
74
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
111,
118
]
} |
in cells from the patient with leprechaunism , the effect of trypsin was much smaller than in the control fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
3,
8
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} |
when casein was used as substrate , physiological concentrations of naturally occurring polyamines such as spermine and spermidine markedly stimulated enzyme activity . | NA | {
"id": "C0037874",
"name": "spermine",
"pos": [
107,
115
]
} | {
"id": "C0037871",
"name": "markedly",
"pos": [
131,
139
]
} |
three types of single-stranded dna are detected in these hybrids : full-length dna molecules of mdg containing one and two long terminal repeats ( minus strand ) and the long terminal repeat itself ( plus strand ) . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
15,
34
]
} | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
79,
92
]
} |
the affinity of ligand for a dna site was estimated from measurements of ligand concentration that causes 50 % protection of the dna site . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
27,
32
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
129,
132
]
} |
conversion of aat from the plp- to pmp-form is accompanied by rotation of the coenzyme ring by approximately 20 degrees ; | NA | {
"id": "C0034266",
"name": "plp",
"pos": [
27,
30
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
78,
86
]
} |
it concerns the domain structure of the enzyme and the topology of the arrangement of beta-strands in pepsin and related aspartic proteases , this topology being quite different from that of all other beta-proteins . | NA | {
"id": "C0030909",
"name": "pepsin",
"pos": [
102,
108
]
} | {
"id": "C0078989",
"name": "aspartic proteases",
"pos": [
121,
139
]
} |
we report three cases of the gianotti-crosti syndrome ( papulovesicular-acro-located syndrome of childhood ) , a self-limited common disease of childhood , which may be caused by various viral infections . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
45,
53
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
133,
140
]
} |
the observation that both hydroxyurea and the structurally related compounds acetohydroxamic acid and n-hydroxyurethane induce dna repair in primary hepatocyte cultures suggests that metabolism-dependent genotoxicity may be a common property of aliphatic hydroxamic acids . | NA | {
"id": "C0050451",
"name": "acetohydroxamic acid",
"pos": [
77,
97
]
} | {
"id": "C0020314",
"name": "hydroxamic acids",
"pos": [
255,
271
]
} |
in the present study , in an attempt to clarify whether bc and 4cmb are uv-like agents , the excision-deficient xeroderma pigmentosum complementation group a fibroblasts and excision-proficient human alveolar tumour cells ( a549 ) were exposed to various doses of these compounds prior to monitoring the inhibition of ce... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
158,
169
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
216,
221
]
} |
purine phosphoribosylating and nucleoside phosphorylating activities as well as purine nucleoside cleaving and adenosine , adenine and guanine deaminating activities were evident . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
0,
6
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
123,
130
]
} |
purine phosphoribosylating and nucleoside phosphorylating activities as well as purine nucleoside cleaving and adenosine , adenine and guanine deaminating activities were evident . | NA | {
"id": "C0028621",
"name": "nucleoside",
"pos": [
31,
41
]
} | {
"id": "C0034136",
"name": "purine nucleoside",
"pos": [
80,
97
]
} |
purine phosphoribosylating and nucleoside phosphorylating activities as well as purine nucleoside cleaving and adenosine , adenine and guanine deaminating activities were evident . | NA | {
"id": "C0034136",
"name": "purine nucleoside",
"pos": [
80,
97
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
111,
120
]
} |
methylated derivatives of the hexose components in this extract , analysed by mass spectrometry , suggest the presence of short sugar chains of alpha-d-mannopyranose and a branched alpha-d-mannan . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
30,
36
]
} | {
"id": "C0024742",
"name": "mannopyranose",
"pos": [
152,
165
]
} |
an electrocardiogram was classified as positive if it showed one or more of the following : evidence of infarction , ischemia , or strain ; | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
104,
114
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
117,
125
]
} |
the ultrastructure of cryptococcus neoformans in the cerebrospinal fluid , which was obtained from a patient suffering from systemic lupus erythematosus and cryptococcal meningitis , before treatment and on the 10th and 20th day after the start of treatment was studied . | NA | {
"id": "C0010414",
"name": "cryptococcus neoformans",
"pos": [
22,
45
]
} | {
"id": "C0085436",
"name": "cryptococcal meningitis",
"pos": [
157,
180
]
} |
one such factor , termed 22k , can induce production of human beta-interferon ( huifn-beta ) in cultured human fibroblasts , thereby rendering these cells resistant to virus infection . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
111,
122
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
149,
154
]
} |
the gene encoding the large-t protein of polyoma virus ( plt ) , the e1a genes of adenoviruses , the viral myc gene ( v-myc ) or rearranged forms of the cellular c-myc gene confer on rat embryo fibroblast ( ref ) cells in primary culture a series of new properties ( 'immortality ' , reduced serum requirement and sensit... | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
153,
161
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
194,
204
]
} |
we now report that focus formation can be induced after transfer of these genes into either ref or established fr3t3 rat cells by subsequent exposure to the tumour promoter 12-o-tetradecanoylphorbol 13-acetate ( tpa ) . | NA | {
"id": "C0016030",
"name": "ref",
"pos": [
92,
95
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
121,
126
]
} |
we have identified a high-affinity binding site in the immunoglobulin mu gene that binds a specific nuclear protein , and have now characterized it fully using nuclear factor 1 ( nf-1 ) , a protein purified from the nuclei of hela cells and required for the in vitro replication of adenovirus ( ad ) dna . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
100,
107
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
190,
197
]
} |
by generating monoclonal antibodies to cell-surface proteins of ctl clones , we have now detected ctl-specific modifications in one of these high-mr membrane proteins , t200 . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
52,
60
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
149,
157
]
} |
furthermore , the expression of the modifications recognized by our antibodies is influenced by soluble factors and also seems to have functional significance , as monoclonal antibodies specific for these novel epitopes block cytolytic activity . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
68,
78
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
164,
185
]
} |
radiological scanning and immunotherapy with mouse tumour-specific monoclonal antibodies have been applied to patients with some success , but a major problem is the neutralization of the mouse antibody induced by repeated administration of heterologous antibodies . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
194,
202
]
} | {
"id": "C0003248",
"name": "heterologous antibodies",
"pos": [
241,
264
]
} |
since an increase in postsynaptic alpha 2-adrenoceptors due to 6-oh-da-administration might have masked a loss of presynaptic alpha 2-adrenergic binding sites , rats were chronically treated with high doses of clonidine in order to prevent a possible supersensitivity of postsynaptic receptors . | NA | {
"id": "C0001639",
"name": "alpha",
"pos": [
34,
39
]
} | {
"id": "C0034784",
"name": "alpha",
"pos": [
126,
131
]
} |
competition experiments with a variety of adenosine analogues gave a pharmacological profile characteristic of ri adenosine receptors with high affinities of n6-substituted derivatives and a marked stereospecificity for n6-phenylisopropyladenosine ( pia ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
42,
51
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
223,
247
]
} |
human chorionic gonadotropin ( hcg beta ) values were determined in the blood of 19 women and 4 men on maintenance hemodialysis . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
0,
28
]
} | {
"id": "C0106132",
"name": "hcg beta",
"pos": [
31,
39
]
} |
calf brain synaptic plasma membranes were saturated under extracellular conditions with [ 14c ] glutamic acid and the resulting labelled membranes fractionated with 0.9 % nacl , distilled water , n-butanol-water , 0.05 mol/l naoh and 0.5 % triton x-100 solutions in this order . | NA | {
"id": "C0790233",
"name": "distilled water",
"pos": [
178,
193
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
206,
211
]
} |
in rats with partial , unilateral lesions of the dopaminergic nigrostriatal pathway , synthesis of dopamine ( da ) per surviving neurone was assessed by measuring the ratio of dopa accumulated after inhibition of aromatic amino acid decarboxylase to dopamine ( dopa/da ratio ) . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
49,
61
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
266,
268
]
} |
patients with normal-pressure hydrocephalus , multi-infarct dementia , and recent cerebral infarction had significantly lower vasoactive intestinal polypeptide ( vip ) levels than age-matched controls ( 11 +/- 3 pmol/l , 17 +/- 4 pmol/l , 21 +/- 4 pmol/l , and 33 +/- 4 pmol/l , respectively ) . | NA | {
"id": "C0011263",
"name": "multi-infarct dementia",
"pos": [
46,
68
]
} | {
"id": "C0007785",
"name": "cerebral infarction",
"pos": [
82,
101
]
} |
the benzodiazepine midazolam produced an anticonflict effect in rats measured in a water lick paradigm following local injection into the basolateral and lateral complex of the amygdala . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
4,
18
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
19,
28
]
} |
the authors suggest that the currently recommended daily caloric allowances for normal women may be excessive for obese gestational diabetics who are not prone to ketosis but have a complex metabolic problem characterized by hyperinsulinemia and insulin resistance . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
225,
241
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
246,
264
]
} |
mullerian duct malformations were found in 8 % and asherman syndrome in 4.8 % of 537 infertile women undergoing hysterosalpingogram and/or hysteroscopy among 840 consecutive infertile couples evaluated . | NA | {
"id": "C0021361",
"name": "infertile women",
"pos": [
85,
100
]
} | {
"id": "C0021359",
"name": "infertile",
"pos": [
174,
183
]
} |
these tubal cysts commonly have been described as hydatids or parovarian cysts , but their relationship to the normal tube has not been identified clearly , their frequency has not been determined , their clinical significance rarely has been considered , and their embryologic origin remains imperfectly understood . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
12,
17
]
} | {
"id": "C0030584",
"name": "parovarian cysts",
"pos": [
62,
78
]
} |
cowden 's syndrome or multiple hamartoma and neoplasia syndrome is a hereditary disorder combining multiple hamartomas of many organs . | NA | {
"id": "C0027651",
"name": "neoplasia syndrome",
"pos": [
45,
63
]
} | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
108,
118
]
} |
symptoms in meniere 's disease are explained by hydrops of the endolymphatic system with recurrent ruptures of the membranous labyrinth . | NA | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
12,
30
]
} | {
"id": "C0206586",
"name": "hydrops",
"pos": [
48,
55
]
} |
the ototoxicity and nephrotoxicity of netilmicin were compared with those of dibekacin , kanamycin and amikacin using rabbits . | NA | {
"id": "C0012024",
"name": "dibekacin",
"pos": [
77,
86
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
89,
98
]
} |
the ototoxicity and nephrotoxicity of netilmicin were compared with those of dibekacin , kanamycin and amikacin using rabbits . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
89,
98
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
103,
111
]
} |
comparing groups defined in terms of the chronicity of their headache problems , it was found that those with a longer history of headache had a higher level of behavioural disruption and a stronger bond between pain experience , and both complaint levels and behavioural avoidance patterns . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
61,
69
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
212,
216
]
} |
the hypoproteinaemia was accompanied by significant hypoalbuminaemia in the protein-malnourished rats and concentrations fell from approximately 33 to 19 mg/ml at the time of peak infection . | NA | {
"id": "C0020639",
"name": "hypoproteinaemia",
"pos": [
4,
20
]
} | {
"id": "C0239981",
"name": "hypoalbuminaemia",
"pos": [
52,
68
]
} |
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