text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
amoxycillin/clavulanic acid was rapidly bactericidal as a simulated intravenous 1.2 g bolus dose , against a strain of klebsiella pneumoniae highly resistant to amoxycillin . | NA | {
"id": "C0054066",
"name": "amoxycillin/clavulanic acid",
"pos": [
0,
27
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
161,
172
]
} |
using escherichia coli a study of the piod values allowed us to separate the beta-lactam antibiotics studied into two groups : those whose piod were concentration-dependent ( ampicillin , carbenicillin , ticarcillin , moxalactam , ceftazidime , cefsulodin , cefotaxime ) and those whose piod were concentration-independe... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
175,
185
]
} | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
349,
359
]
} |
using escherichia coli a study of the piod values allowed us to separate the beta-lactam antibiotics studied into two groups : those whose piod were concentration-dependent ( ampicillin , carbenicillin , ticarcillin , moxalactam , ceftazidime , cefsulodin , cefotaxime ) and those whose piod were concentration-independe... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
175,
185
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
362,
373
]
} |
using escherichia coli a study of the piod values allowed us to separate the beta-lactam antibiotics studied into two groups : those whose piod were concentration-dependent ( ampicillin , carbenicillin , ticarcillin , moxalactam , ceftazidime , cefsulodin , cefotaxime ) and those whose piod were concentration-independe... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
175,
185
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
376,
388
]
} |
the minimum bactericidal concentration of penicillin for this strain was more than 64 mg/l and was higher than the peak penicillin serum level obtained in rats 30 min after the iv injection of 60 mg/kg , and in man after an oral dose of 2 g of phenoxymethyl penicillin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
42,
52
]
} | {
"id": "C0030840",
"name": "phenoxymethyl penicillin",
"pos": [
244,
268
]
} |
using cefmenoxime , cefotaxime , latamoxef ( moxalactam ) and ceftriaxone as examples , the vast differences between the total concentration of the antibiotic in serum and the concentration of the non-protein bound antibiotic in the tissue water are demonstrated . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
6,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
20,
30
]
} |
using cefmenoxime , cefotaxime , latamoxef ( moxalactam ) and ceftriaxone as examples , the vast differences between the total concentration of the antibiotic in serum and the concentration of the non-protein bound antibiotic in the tissue water are demonstrated . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
20,
30
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
62,
73
]
} |
we studied the effects of superoxide dismutase ( sod ) , an enzyme that converts superoxide into peroxide , on the cardiopulmonary response to endotoxin in sheep . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
26,
36
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
97,
105
]
} |
we conclude that peroxide , hydroxyl ion , and/or other free radicals formed by the action of sod must be responsible for a portion of the endotoxin response rather than superoxide itself . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
17,
25
]
} | {
"id": "C0038836",
"name": "superoxide",
"pos": [
170,
180
]
} |
to investigate the relationship between dopamine ( da ) released into the bloodstream and sympathoadrenal activity , levels of free da , norepinephrine ( ne ) , and epinephrine ( e ) in plasma were recorded in four dogs subjected to three tests : treadmill exercise at two work levels [ 55 and 75 % maximal o2 uptake ; 1... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
137,
151
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
165,
176
]
} |
this finding suggests that the effect of drugs such as theophylline in eliminating periodic breathing may be unrelated to the fact that they also reduce fatigue . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
5,
12
]
} | {
"id": "C0015672",
"name": "fatigue",
"pos": [
153,
160
]
} |
lung weight change ( delta w ) was measured as the opposite of the change in weight of the extracorporeal blood reservoir . | NA | {
"id": "C0005911",
"name": "weight change",
"pos": [
5,
18
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
77,
83
]
} |
tracer studies with 125i-albumin before and 3 days after the start of o2 breathing confirmed the development of increased lung vascular permeability to protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
25,
32
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
152,
159
]
} |
sigma ddt and pcb residues declined rapidly between 1969 and 1982 in extractable lipids of both abdominal and egg fats , while dieldrin declined less markedly over the same period . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
81,
87
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
114,
118
]
} |
the lc method uses paromomycin as an internal standard , and separates neomycin from streptomycin or dihydrostreptomycin because they have different retention times . | NA | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
19,
30
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
71,
79
]
} |
the interlaboratory determination of npr and rnpr was also more reproducible than that of most essential amino acids ( cv up to 10.0 % ) , especially tryptophan ( cv up to 23.7 % ) , cystine ( cv up to 17.6 % ) , and methionine ( cv up to 16.1 % ) . | NA | {
"id": "C0002525",
"name": "essential amino",
"pos": [
95,
110
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
217,
227
]
} |
escherichia coli k-12 strains in the absence of the lactose carrier grew on the disaccharide melibiose as the sole source of carbon . | NA | {
"id": "C0022949",
"name": "lactose",
"pos": [
52,
59
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
80,
92
]
} |
escherichia coli k-12 strains in the absence of the lactose carrier grew on the disaccharide melibiose as the sole source of carbon . | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
80,
92
]
} | {
"id": "C0025228",
"name": "melibiose",
"pos": [
93,
102
]
} |
to investigate this possibility in streptococcus lactis 133 , lactose derivatives have been prepared containing 14c-labeled 2-deoxy-glucose ( 2dg ) , 2-deoxy-2-fluoro-d-glucose ( 2fg ) , or alpha-methylglucoside as the aglycon substituent of the disaccharide . | NA | {
"id": "C0022949",
"name": "lactose",
"pos": [
62,
69
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
246,
258
]
} |
anaerobiosis induced an accumulation of polyphosphates ( poly pi ) in a phosphate-rich medium by an alkaline-phosphatase constitutive mutant of escherichia coli . | NA | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
40,
54
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
72,
81
]
} |
plasmids carrying a part of this 5.6-kilobase-pair dna ( pse-130 ) or fragments derived from this dna in different orientations ( pse-126 and pse-129 ) inhibited the production of active formate hydrogenlyase . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
2,
3
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
98,
101
]
} |
the average chain growth rates of rrna and of total rna were not affected by a thermal inactivation of dna gyrase in a temperature-sensitive gyrb mutant of escherichia coli . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
34,
38
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
52,
55
]
} |
the fraction of rrna in total pulse-labeled rna was not altered by inactivation of the enzyme , indicating that the latter is not required to actively maintain a high rate of synthesis of this rna species . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
16,
20
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
193,
196
]
} |
35s incorporation studies showed that candida tropicalis trna contained two thionucleosides , one of which was identified as 5-methyl-2-thiouridine . | NA | {
"id": "C0039922",
"name": "thionucleosides",
"pos": [
76,
91
]
} | {
"id": "C0039959",
"name": "thiouridine",
"pos": [
136,
147
]
} |
from the bilayer packing periodicities , a geometrical model of the extensions of the lps regions lipid a , 2-keto-3-deoxyoctulosonic acid , and o-specific chain along the membrane normal could be calculated . | NA | {
"id": "C0023767",
"name": "a",
"pos": [
12,
13
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
86,
89
]
} |
comparison of these structural properties with those known for natural phospholipids in biological membranes indicates that the high state of order of the lipid a portion of lps might be an important factor in the structural role and permeation barrier functions of lps in the outer membrane of gram-negative bacteria . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
155,
162
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
266,
269
]
} |
these abnormal movements can be seen in several other syndromes and disease processes , which are briefly reviewed . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
54,
63
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
68,
75
]
} |
this sequence is very similar to sequences of fluorescein-labeled peptides from the atp binding sites of na , k-atpase and ca2+-atpase , and suggests that the active site structures of these ion transport atpases are similar . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
123,
126
]
} | {
"id": "C0001473",
"name": "atpases",
"pos": [
205,
212
]
} |
the noncovalently associated gdp acts as a competitive inhibitor of the interaction of added guanine nucleotides with p21 . | NA | {
"id": "C0018340",
"name": "gdp",
"pos": [
29,
32
]
} | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
93,
112
]
} |
creatinine to cytosine activity ratios varied from 1:3.75 ( iron ( ii ) chloride ) , to 1:0.9 ( zinc chloride ) , to 1:0.06 ( nickel chloride ) . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
72,
80
]
} | {
"id": "C0078774",
"name": "zinc",
"pos": [
96,
100
]
} |
upon induced variation of membrane lipid acyl chain unsaturation in acholeplasma laidlawii , the cells strongly change in a characteristic manner the proportions of individual ( charged and noncharged ) polar lipids synthesized . | NA | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
26,
40
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
209,
215
]
} |
microelectrophoresis of these lipids indicated an almost constant lipid membrane zeta-potential of about -35 mv . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
30,
36
]
} | {
"id": "C0025249",
"name": "lipid membrane",
"pos": [
66,
80
]
} |
non-histone nuclear proteins do not form complexes with double-stranded unsubstituted dna that are resistant to dissociation with nacl and sarkosyl but are capable of forming such complexes with single-stranded dna regardless of whether it contains 5-azacytosine residues or not . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
4,
11
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
12,
28
]
} |
however , it can be demonstrated 1 ) that single-stranded regions do not account for stable binding of proteins to native [ 5-aza-c ] dna and 2 ) that many nuclear proteins which form stable complexes with single-stranded dna are incapable of forming such complexes with double-stranded [ 5-aza-c ] dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
206,
225
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
299,
302
]
} |
analogous depletion of non-histone nuclear proteins capable of forming stable complexes with [ 5-aza-c ] dna in vitro is observed , suggesting that the same proteins can form highly stable complexes with [ 5-aza-c ] dna in vitro and in vivo . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
27,
34
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
35,
51
]
} |
analogous depletion of non-histone nuclear proteins capable of forming stable complexes with [ 5-aza-c ] dna in vitro is observed , suggesting that the same proteins can form highly stable complexes with [ 5-aza-c ] dna in vitro and in vivo . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
35,
51
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
157,
165
]
} |
formation of stable complexes between non-histone nuclear proteins and [ 5-aza-c ] dna could potentially affect not only the activity of dna methyltransferase but the action of other regulatory proteins or enzymes that interact with dna . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
42,
49
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
50,
66
]
} |
the nitric oxide ( n = o ) free radical exhibits potent cytocidal , mutagenic and vasodilatory properties . | NA | {
"id": "C0028128",
"name": "nitric oxide",
"pos": [
4,
16
]
} | {
"id": "C0016693",
"name": "free radical",
"pos": [
27,
39
]
} |
a reduction of intracellular utp contents by different concentrations of d-galactosamine led to a dose-dependent increase of 14co2 incorporation into the sum of all acid-soluble uracil nucleotides . | NA | {
"id": "C0042010",
"name": "utp",
"pos": [
29,
32
]
} | {
"id": "C0041921",
"name": "uracil nucleotides",
"pos": [
178,
196
]
} |
we studied the kinetics of synthesis and secretion of the acute phase plasma protein , c-reactive protein , in primary hepatocyte cultures prepared from rabbits manifesting differing degrees of the acute phase response to inflammatory stimulus . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
58,
69
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
87,
105
]
} |
enzyme activity in brain extracts or purified brain isozymes was titrated above 90 % with m4 anti-igg and 20 % with l4 anti-igg . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
0,
6
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
52,
60
]
} |
half-maximal rates of dephosphorylation were observed at concentrations of calmodulin ranging from 3 x 10 ( -8 ) to 10 ( -6 ) m at saturating concentrations of divalent cations depending on the substrate used and the particular cation chosen . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
160,
176
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
228,
234
]
} |
when prekallikrein is activated endogenously in plasma by the addition of kaolin or hageman factor fragment , approximately 84 % of kallikrein is now bound to c-1 inactivator and 16 % to alpha 2-macroglobulin . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
5,
18
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
132,
142
]
} |
these phosphorylation sites which may be repeated an average of 20 times in each of the high molecular weight proteins , are different from the phosphorylation sites seen in other basic nuclear proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
110,
118
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
186,
202
]
} |
each of the class i monoclonal antibodies inhibited abortive initiation , and four of these antibodies also blocked the binding of camp x crp to the lac dna fragment . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
20,
41
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
92,
102
]
} |
studies on fibrinogen ny-1 and the fibrinogen from her brother , designated ny-1a , showed that both have abnormal thrombin-nonclottable fibrinogen ( 50 % of the total fibrinogen in ny-1 and 35-40 % in ny-1a ) and that the trait is heterozygous and autosomal codominant . | NA | {
"id": "C0016013",
"name": "abnormal",
"pos": [
106,
114
]
} | {
"id": "C0016006",
"name": "fibrinogen",
"pos": [
168,
178
]
} |
based on the kinetics of accumulation , malic enzyme mrna had a half-life of 3-5 h in the livers of fed ducklings . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
13,
21
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
64,
73
]
} |
dose-response curves for receptor and pp120 phosphorylation stimulated by pork insulin were essentially identical , and showed the appropriate specificity ( insulin much greater than proinsulin ) for a receptor-mediated event . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
79,
86
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
183,
193
]
} |
these two amino acids , methionine and alanine , are coded on two separate exons split by the largest intron of the entire gene . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
10,
21
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
39,
46
]
} |
we have examined the binding of purified uvsx protein to single-stranded dna ( ssdna ) and to double-stranded dna ( dsdna ) using electron microscopy to visualize the complexes that are formed and double label analysis to measure their protein content . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
57,
76
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
94,
113
]
} |
the presence of these kyphoses and scolioses in the same spine , separated by only a few vertebrae , emphasises the importance of the sagittal plane in idiopathic spinal deformities and strongly suggests that idiopathic scoliosis and scheuermann 's disease share a common pathological process . | NA | {
"id": "C0022821",
"name": "kyphoses",
"pos": [
22,
30
]
} | {
"id": "C0036310",
"name": "scheuermann 's",
"pos": [
234,
248
]
} |
thus primary lymphoedema may be defined as lymphoedema caused by a primary abnormality or disease of the lymph conducting elements of the lymph vessels or lymph nodes . | NA | {
"id": "C0024236",
"name": "lymphoedema",
"pos": [
13,
24
]
} | {
"id": "C0024228",
"name": "disease",
"pos": [
90,
97
]
} |
these data suggest that pdgf-induced competence and stimulation of cell growth in quiescent fibroblasts are associated with specific rapid alterations in the cellular organization of vinculin and actin . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
92,
103
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
158,
166
]
} |
indeed , heparan sulfate isolated from the surface of the postconfluent smcs exhibits a specific antiproliferative activity which is 13-fold greater than mucopolysaccharide obtained from the surface of exponentially growing smcs and more than 40-fold greater than commercially available heparin . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
9,
24
]
} | {
"id": "C0017973",
"name": "mucopolysaccharide",
"pos": [
154,
172
]
} |
indeed , heparan sulfate isolated from the surface of the postconfluent smcs exhibits a specific antiproliferative activity which is 13-fold greater than mucopolysaccharide obtained from the surface of exponentially growing smcs and more than 40-fold greater than commercially available heparin . | NA | {
"id": "C0017973",
"name": "mucopolysaccharide",
"pos": [
154,
172
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
287,
294
]
} |
furthermore , other investigations indicate that the small amount of growth inhibitory activity intrinsic to heparan sulfate isolated from the surface of exponentially growing smcs is due to residual , biologically active , mucopolysaccharide produced by the primary postconfluent smcs from which the exponentially growi... | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
109,
124
]
} | {
"id": "C0017973",
"name": "mucopolysaccharide",
"pos": [
224,
242
]
} |
if the lipid fraction is derived through chloroform-methanol extraction of natural ciliary membranes , a moderate increase in density occurs upon reconstitution , but the protein is adsorbed and most is removed by a simple low ionic strength wash , in contrast to vesicles reconstituted from membrane proteins where even... | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
292,
309
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
360,
367
]
} |
we studied the laminar organization of 3t3 fibroblast cells growing on glass slides by use of total internal reflection illumination to excite fluorescence emission ( tirf ) from labeled molecules and stained cellular compartments that are very close to the cell-substrate contact region . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
43,
53
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
209,
217
]
} |
the distribution of the intermediate filament proteins vimentin and desmin in developing and mature myotubes in vivo was studied by single and double immunoelectron microscopic labeling of ultrathin frozen sections of iliotibialis muscle in 7-21-d-old chick embryos , and neonatal and 1-d-old postnatal chicks . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
24,
54
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
55,
63
]
} |
the attachment of embryonic chick retinal cells to the 170,000-mol-wt protein also depends upon interactions between the protein and the heparan sulfate proteoglycan , since heparan sulfate in solution disrupts adhesion of chick neural retina cells to glass surfaces coated with the 170,000-mol-wt protein . | NA | {
"id": "C0062503",
"name": "heparan sulfate proteoglycan",
"pos": [
137,
165
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
174,
189
]
} |
thus , benzo ( a ) pyrene uptake by cells is a simple partitioning phenomenon , controlled by the relative lipid volumes of extracellular donor lipoproteins and of cells , and does not involve lipoprotein endocytosis as an obligatory step . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
107,
112
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
193,
204
]
} |
using immunofluorescence microscopy and two-dimensional gel electrophoresis , we compared the cytoskeletal proteins expressed by human amnion epithelium in situ , obtained from pregnancies of from 10-wk to birth , with the corresponding proteins from cultured amnion epithelial cells and cultures of cells from the amnio... | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
94,
115
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
237,
245
]
} |
we conclude that serially cultivated rat endometrial cells retain hormonal properties expressed in vivo while exhibiting some keratinocyte character . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
53,
58
]
} | {
"id": "C0022567",
"name": "character",
"pos": [
139,
148
]
} |
second , the potency ratios for the responses to isoproterenol , epinephrine , and norepinephrine shift from 1.1:1.0:1.0 in the myoblast to 3.3:2.1:1.0 in the myotube . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
65,
76
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
83,
97
]
} |
the elution volume of amylopectin ( ve = 2.5 ml ) indicated that this starch component was fractionated on the column system despite its very large molecular size . | NA | {
"id": "C0002728",
"name": "amylopectin",
"pos": [
22,
33
]
} | {
"id": "C0038179",
"name": "starch",
"pos": [
70,
76
]
} |
the method developed proved useful to monitor the purity of amylose and amylopectin preparations , and to estimate rapidly the amylose : amylopectin ratio of starch samples . | NA | {
"id": "C0002732",
"name": "amylose",
"pos": [
60,
67
]
} | {
"id": "C0038179",
"name": "starch",
"pos": [
158,
164
]
} |
the method developed proved useful to monitor the purity of amylose and amylopectin preparations , and to estimate rapidly the amylose : amylopectin ratio of starch samples . | NA | {
"id": "C0002728",
"name": "amylopectin",
"pos": [
72,
83
]
} | {
"id": "C0038179",
"name": "starch",
"pos": [
158,
164
]
} |
in this paper , we describe a new ion-pairing high-performance liquid chromatographic assay for ara-c in biological samples that can separate ara-c from its nucleotides , metabolites , and naturally occurring ribonucleotides in a single chromatographic step with a lower limit of quantitation of 5 pmol for ara-c and 10 ... | NA | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
157,
168
]
} | {
"id": "C0035548",
"name": "ribonucleotides",
"pos": [
209,
224
]
} |
mitoxantrone is one of the newer anthracenedione derivatives which has already been studied in phase i and ii trials , where it has shown significant antitumor activity against a variety of human tumours . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
0,
12
]
} | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
33,
48
]
} |
the in vitro secretion of pth by dispersed human parathyroid cells was examined under conditions of low and high extracellular ca+2 using tissue from patients with primary hyperparathyroidism and hyperparathyroidism resulting from chronic renal failure ( crf ) . | NA | {
"id": "C0221002",
"name": "primary hyperparathyroidism",
"pos": [
164,
191
]
} | {
"id": "C0020502",
"name": "hyperparathyroidism",
"pos": [
196,
215
]
} |
plasma acth , cortisol , arginine vasopressin ( avp ) , epinephrine , norepinephrine , and crh were measured 30 min before and up to 150 min after crh administration . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
56,
67
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
70,
84
]
} |
to determine whether morphine 's effect on acth and cortisol was due to a direct action on the corticotroph cell , dispersed rat pituitary cells were perifused with medium containing 1 microgram/ml morphine sulfate or medium alone . | NA | {
"id": "C0026549",
"name": "morphine 's",
"pos": [
21,
32
]
} | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
198,
214
]
} |
we studied 15 anovulatory women undergoing ovulation induction with purified human urinary fsh or purified human urinary fsh and lh [ human menopausal gonadotropins ( hmg ) ] . | NA | {
"id": "C0524639",
"name": "human urinary fsh",
"pos": [
77,
94
]
} | {
"id": "C0025326",
"name": "human menopausal",
"pos": [
134,
150
]
} |
the km values for the cofactor nad+ were similar regardless which substrate , dehydroepiandrosterone ( dha ) , pregnenolone , or 17-hydroxypregnenolone ( 17oh-delta 5p ) , was used . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
111,
123
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
129,
151
]
} |
we employed primary cultures of pulmonary alveolar macrophages from two patients with biopsy-proven pulmonary sarcoidosis and a recent or current clinical abnormality in calcium metabolism to synthesize in vitro a 1,25-dihydroxyvitamin d3 [ 1,25- ( oh ) 2d3 ] -like metabolite from 25-hydroxyvitamin d3 ( 25ohd3 ) . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
282,
302
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
305,
311
]
} |
the drugs tested were ampicillin , ticarcillin , mezlocillin , piperacillin , azlocillin , cefazolin , cefotaxime , moxalactam , cefoperazone , ceftriaxone , and imipenem . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
22,
32
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
49,
60
]
} |
the drugs tested were ampicillin , ticarcillin , mezlocillin , piperacillin , azlocillin , cefazolin , cefotaxime , moxalactam , cefoperazone , ceftriaxone , and imipenem . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
22,
32
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
63,
75
]
} |
the drugs tested were ampicillin , ticarcillin , mezlocillin , piperacillin , azlocillin , cefazolin , cefotaxime , moxalactam , cefoperazone , ceftriaxone , and imipenem . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
22,
32
]
} | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
78,
88
]
} |
the drugs tested were ampicillin , ticarcillin , mezlocillin , piperacillin , azlocillin , cefazolin , cefotaxime , moxalactam , cefoperazone , ceftriaxone , and imipenem . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
103,
113
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
144,
155
]
} |
forty combinations of capture-conjugate monoclonal antibody pairs were screened for detection of nanogram amounts of purified bhv-1 by using a double-antibody-sandwich elisa in which antigen and conjugated antibody were simultaneously added to antibody-coated wells . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
40,
59
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
244,
252
]
} |
the accuracy in quantitating tobramycin , netilmicin , kanamycin , and amikacin at concentrations in the therapeutic range was greater than 90 % , with a mean recovery of 102.8 % . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
55,
64
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
71,
79
]
} |
the radioenzymatic assay correlates well with the bioassay ( tobramycin and netilmicin ) and radioimmunoassay ( amikacin and kanamycin ) ; | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
112,
120
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
125,
134
]
} |
two hundred and twelve micrococcaceae isolates were obtained from 82 men with nongonococcal urethritis , 24 women with vaginitis , and 54 girls with vulvovaginitis . | NA | {
"id": "C0042267",
"name": "vaginitis",
"pos": [
119,
128
]
} | {
"id": "C0042998",
"name": "vulvovaginitis",
"pos": [
149,
163
]
} |
spondylolysis or spondylolisthesis ( grade i or ii ) at l5-s1 was also found in 32 % of the patients . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
0,
13
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
17,
34
]
} |
the presence of anti-scl-86 antibodies seemed to correlate with the diagnosis of diffuse scleroderma since they were found in 13 out of 22 diffuse scleroderma patients and in only one out of 11 patients with limited scleroderma . | NA | {
"id": "C0036421",
"name": "diffuse scleroderma",
"pos": [
81,
100
]
} | {
"id": "C0748540",
"name": "limited scleroderma",
"pos": [
208,
227
]
} |
we conclude that insulin resistance and/or hyperinsulinemia ( a ) are present in the majority of hypertensives , ( b ) constitute a common pathophysiologic feature of obesity , glucose intolerance , and hypertension , possibly explaining their ubiquitous association , and ( c ) may be linked to the increased peripheral... | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
17,
35
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
43,
59
]
} |
a very strong correlation ( r = 0.98 ) was found between inhibition of t-pa and of urokinase in all conditions , suggesting that this fast-acting inhibitor reacts with both plasminogen activators . | NA | {
"id": "C0032143",
"name": "t-pa",
"pos": [
71,
75
]
} | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
173,
195
]
} |
we used the technique of western blotting with antibodies against purified bovine liver branched chain alpha-ketoacid dehydrogenase complex to screen mitochondrial proteins from cultured human fibroblasts for immunocrossreactive proteins . | NA | {
"id": "C0949610",
"name": "mitochondrial proteins",
"pos": [
150,
172
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
229,
237
]
} |
two ruminococcus torques strains , ix-70 and viii-239 , produced blood group a- and h-degrading alpha-glycosidase activities , sialidase , and the requisite beta-glycosidases ; | NA | {
"id": "C0027803",
"name": "sialidase",
"pos": [
127,
136
]
} | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
162,
174
]
} |
in fibroblasts from two patients with dd ii , [ 3h ] 24,25 ( oh ) 2d3 formation was unmeasurable ( below 0.2 pmol/10 ( 6 ) cells per 30 min ) at 1,25 ( oh ) 2d3 concentrations up to 10 ( -6 ) m . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
3,
14
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
123,
128
]
} |
ethanol feeding increased free cholesterol in all plasma lipoprotein fractions , and esterified cholesterol in very low density lipoprotein , intermediate density lipoprotein , and high density lipoprotein ( hdl ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
57,
68
]
} | {
"id": "C0065063",
"name": "intermediate density lipoprotein",
"pos": [
142,
174
]
} |
by contrast the increase in hdl-cholesterol ( mainly esterified ) appears to be a poor indicator of cholesterol mobilization . | NA | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
28,
43
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
100,
111
]
} |
the total cultivable oral flora was susceptible to the tetracyclines including tetracycline itself , minocycline , doxycycline , and oxytetracycline and to erythromycin . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
55,
68
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
101,
112
]
} |
the total cultivable oral flora was susceptible to the tetracyclines including tetracycline itself , minocycline , doxycycline , and oxytetracycline and to erythromycin . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
55,
68
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
115,
126
]
} |
the total cultivable oral flora was susceptible to the tetracyclines including tetracycline itself , minocycline , doxycycline , and oxytetracycline and to erythromycin . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
55,
68
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
133,
148
]
} |
these data , combined with the previous findings that some tetracyclines exhibit marked substantivity and collagenase inhibition activity , indicate that tetracycline or minocycline are likely to be good choices in the treatment or prevention of oral diseases . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
59,
72
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
170,
181
]
} |
lymphopenia accompanying the immunodeficiency appears to be due to depletion of a particular population of t-cells ( thymus derived ) that have reduced response to mitogens and decreased numbers as the lamb matures . | NA | {
"id": "C0024312",
"name": "lymphopenia",
"pos": [
0,
11
]
} | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
29,
45
]
} |
as determined by milk progesterone , rectal palpation was more accurate for diagnosis of luteal cysts than for diagnosis of follicular cysts . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
96,
101
]
} | {
"id": "C0016427",
"name": "follicular",
"pos": [
124,
134
]
} |
the ada has recommended that no more than 120 mg fluoride ( 264 mg naf ) be dispensed at any one time . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
49,
57
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
67,
70
]
} |
blood samples ( 0.5 ml ) were collected before and at timed intervals after cold immersion ( 0 , 15 and 60 min ) and were later assayed for content of norepinephrine and epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
151,
165
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
170,
181
]
} |
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