text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
we suggest that a combination of ploidy and percentage of cells scattered outside the modal peaks is a more sensitive method for optimal cytochemical malignancy grading in breast carcinomas . | nichd_parent_of | {
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} | {
"id": "C0678222",
"name": "breast carcinomas",
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} |
the finding that splenic atrophy is associated with a high complication rate in colitis has led to a long-term , prospective study of spleen size in inflammatory bowel disease . | nichd_parent_of | {
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} | {
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aspirin showed a positive , but non-significant trend towards reduced numbers of cardiac events , non-fatal infarcts and total mortality in patients who had experienced at least one myocardial infarction . | nichd_parent_of | {
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"name": "infarcts",
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} | {
"id": "C0027051",
"name": "myocardial infarction",
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the placental villous surface area and ratios of villous surface area to body weight , length and head circumference were determined in 40 light-for-dates infants born at term . | nichd_parent_of | {
"id": "C1444754",
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} | {
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when infants were categorised by length , head circumference and ponderal index , the short infants and infants with small heads had a mean villous surface area similar to that of their peers of normal length and head circumference . | nichd_parent_of | {
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} | {
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this monoclonal , which recognized only serotype 3 viruses in an enzyme-linked immunosorbent assay , could be useful in assays for serotyping rotavirus directly in stool samples . | nichd_parent_of | {
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the highly potent and selective anti-dna virus agent ( s ) -9- ( 3-hydroxy-2-phosphonylmethoxypropyl ) adenine [ ( s ) -hpmpa ] was found to inhibit in vitro the replication of a number of clinical varicella-zoster virus strains within the concentration range of 0.63-5.7 ng/ml . | nichd_parent_of | {
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} | {
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"name": "varicella-zoster virus",
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using monoclonal antibodies with the immunoperoxidase technique the distribution pattern of class i and class ii antigens of the major histocompatibility complex ( mhc ) , and of the lymphocyte subsets have been studied in intestinal biopsies from children without mucosal lesions , from children with coeliac disease ( ... | nichd_parent_of | {
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} | {
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titres of virus recovered ranged from 10 ( 4 ) to 10 ( 5 ) tcid50/ml of shellfish extract for poliovirus and from 10 ( 3 ) to 10 ( 5 ) rfu/ml of shellfish extract for hav . | nichd_parent_of | {
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} | {
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"name": "poliovirus",
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patients with acute myeloid leukaemia , fab classification m1 , m2 and m3 ( m1-3 ) developed skin reactions more often than those of types m4 and m5 ( m4-5 ) . | nichd_parent_of | {
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} | {
"id": "C1879321",
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the convergent and discriminant validity of three operationalizations of the psychosomatic family features -- enmeshment , rigidity , overprotectiveness , and lack of conflict resolution , as described by minuchin and colleagues -- are tested in families that include patients with eating disorders , especially anorexia... | nichd_parent_of | {
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"name": "eating disorders",
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282,
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} | {
"id": "C0003125",
"name": "anorexia",
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312,
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} |
the convergent and discriminant validity of three operationalizations of the psychosomatic family features -- enmeshment , rigidity , overprotectiveness , and lack of conflict resolution , as described by minuchin and colleagues -- are tested in families that include patients with eating disorders , especially anorexia... | nichd_parent_of | {
"id": "C0013473",
"name": "eating disorders",
"pos": [
282,
298
]
} | {
"id": "C0006370",
"name": "bulimia",
"pos": [
333,
340
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} |
bilateral tubal occlusion and other infectious infertility etiologies were clearly related to a woman 's history of sexually transmitted disease , pelvic inflammatory disease , and pregnancy complications . | nichd_parent_of | {
"id": "C0009450",
"name": "infectious",
"pos": [
36,
46
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} | {
"id": "C0242172",
"name": "pelvic inflammatory disease",
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147,
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} |
in conclusion , management of unexpected sdt during opu include the following therapeutic goals : ( 1 ) complete eradication of the tumor to eliminate the remote possibility of malignancy and recurrence ; | nichd_parent_of | {
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} | {
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"name": "malignancy",
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} |
multiple pregnancy occurred in 16 cases , two of which were triplet pregnancies and one a quadruplet pregnancy . | nichd_parent_of | {
"id": "C0032989",
"name": "multiple pregnancy",
"pos": [
0,
18
]
} | {
"id": "C0152151",
"name": "triplet pregnancies",
"pos": [
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} |
multiple pregnancy occurred in 16 cases , two of which were triplet pregnancies and one a quadruplet pregnancy . | nichd_parent_of | {
"id": "C0032989",
"name": "multiple pregnancy",
"pos": [
0,
18
]
} | {
"id": "C0152152",
"name": "quadruplet pregnancy",
"pos": [
90,
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]
} |
the five-year survival rate , and thus the prognosis for glandular carcinomas of the cervical glands , depends primarily on the clinical stage of the disease , though also on the histological type and the degree of differentiation of the tumor . | nichd_parent_of | {
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} | {
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"name": "tumor",
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} |
idiopathic uveitis ( iu ) may occur as either an isolated ocular disease or with other systemic diseases such as crohn 's disease ( cd ) . | nichd_parent_of | {
"id": "C0012634",
"name": "disease",
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} | {
"id": "C0442893",
"name": "systemic diseases",
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there are no specific signs indicative of malignancy though the majority of the differentiated carcinomas and all anaplastic tumors present as a hypoechoic mass . | nichd_parent_of | {
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"name": "tumors",
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} | {
"id": "C0577559",
"name": "mass",
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} |
virus-specific iga and igg3 may support conventional serological methods ( igm , igg ) indicating recent infection/reactivation with vzv , ebv and possibly cmv . | nichd_parent_of | {
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"name": "virus",
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0,
5
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} | {
"id": "C0042338",
"name": "vzv",
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} |
the therapeutic efficacy of the two drugs was evaluated on the basis of bacteriological and clinical examinations . | nichd_parent_of | {
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"name": "evaluated",
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} | {
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} |
development of mental disorders in left-sided frontal tumours mainly depends on tumour localization , while in right-sided ones tumour size and malignancy are the determining factors . | nichd_parent_of | {
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"name": "tumour",
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} | {
"id": "C0006826",
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} |
the sodium-independent binding of taurine and gaba were determined with mouse brain membranes subjected to various freezing-thawing cycles , washing procedures and triton x-100 treatments . | nichd_parent_of | {
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personal characteristics of interest were body height and weight , hand grip strength , smoking habits , history of respiratory symptoms and disease , and hematocrit . | nichd_parent_of | {
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"name": "characteristics",
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} | {
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"name": "weight",
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however , two of the cancers were lymphomas , and this incidence is significantly ( p less than 0.01 ) higher than that expected in a similarly matched population . | nichd_parent_of | {
"id": "C0006826",
"name": "cancers",
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} | {
"id": "C0024299",
"name": "lymphomas",
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however , they do not appear to correlate with the degree of tumoral differentiation , and are of no assistance in the separation of benign and malignant sudoriferous neoplasms . | nichd_parent_of | {
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} | {
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} |
this study investigates the relation of spontaneous ventricular arrhythmia on ambulatory electrocardiographic ( ecg ) monitoring to the subsequent inducibility of ventricular tachycardia during programmed electrical stimulation . | nichd_parent_of | {
"id": "C0085612",
"name": "ventricular arrhythmia",
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} | {
"id": "C0042514",
"name": "ventricular tachycardia",
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} |
seventy-five patients ( group i ) had inducible ventricular arrhythmias ( including nonsustained and sustained ventricular tachycardia and ventricular fibrillation ) and 33 patients ( group ii ) had no inducible arrhythmias . | nichd_parent_of | {
"id": "C0085612",
"name": "ventricular arrhythmias",
"pos": [
48,
71
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
139,
163
]
} |
in 13 ( 17 % ) in group i arrhythmias became noninducible , and in 4 ( 5 % ) sustained ventricular arrhythmias became nonsustained after administration of conventional drugs . | nichd_parent_of | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
26,
37
]
} | {
"id": "C0085612",
"name": "ventricular",
"pos": [
87,
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} |
other viruses causing infection in these children included herpes simplex virus , varicella-zoster virus , adenovirus , parainfluenza virus , respiratory syncytial virus , and rotavirus . | nichd_parent_of | {
"id": "C0042776",
"name": "viruses",
"pos": [
6,
13
]
} | {
"id": "C0042338",
"name": "varicella-zoster virus",
"pos": [
82,
104
]
} |
other viruses causing infection in these children included herpes simplex virus , varicella-zoster virus , adenovirus , parainfluenza virus , respiratory syncytial virus , and rotavirus . | nichd_parent_of | {
"id": "C0042776",
"name": "viruses",
"pos": [
6,
13
]
} | {
"id": "C0035870",
"name": "rotavirus",
"pos": [
176,
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]
} |
the production of ema is increased in both squamous and non-squamous epithelium in a variety of diseases including many neoplasms . | nichd_parent_of | {
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} | {
"id": "C0027651",
"name": "neoplasms",
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120,
129
]
} |
the relation between antepartum fetal heart rate ( fhr ) non stress test ( nst ) , maternal serum estriol , intrapartum fhr change , birth weight , placental findings and apgar score were studied in 168 normal gestations and 36 high-risk pregnancies including 25 eph-gestosis cases . | nichd_parent_of | {
"id": "C0018810",
"name": "heart rate",
"pos": [
38,
48
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} | {
"id": "C0018811",
"name": "fhr",
"pos": [
120,
123
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} |
it is therefore concluded that the metabolic consequences of a combined deficiency of the two enzymes are unlikely to be responsible for the interpatient variability of the hematologic response to deficiency of glucose-6-phosphate dehydrogenase . | nichd_parent_of | {
"id": "C0149676",
"name": "of",
"pos": [
58,
60
]
} | {
"id": "C2939465",
"name": "deficiency of glucose-6-phosphate",
"pos": [
197,
230
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} |
relative to united states white male mortality experience , there were no statistically significant deviations from expected for the following categories : all causes , total malignant neoplasms , or specific malignancies of particular interest : stomach cancer , liver cancer , connective and other soft-tissue cancer ,... | nichd_parent_of | {
"id": "C0006826",
"name": "cancer",
"pos": [
255,
261
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} | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
325,
334
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} |
the individual end points potentially examined , such as fetal loss , subfertility , and congenital malformations observed at birth , are on a continuum by severity of effect : the most extreme effect of the three being infertility because no pregnancy is possible , and the least extreme , congenital malformations reco... | nichd_parent_of | {
"id": "C0027361",
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} | {
"id": "C0015965",
"name": "fetal",
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thus vaccination with h. influenzae type b polysaccharide-outer membrane protein conjugate vaccine primes the immune system to an igg memory antibody response to either type b polysaccharide or conjugate vaccine . | nichd_parent_of | {
"id": "C3273243",
"name": "polysaccharide",
"pos": [
43,
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]
} | {
"id": "C0206515",
"name": "conjugate vaccine",
"pos": [
194,
211
]
} |
ontogeny of phytohemagglutinin-induced gamma interferon by leukocytes of healthy infants and children : evidence for decreased production in infants younger than 2 months of age . | nichd_parent_of | {
"id": "C0008059",
"name": "children",
"pos": [
93,
101
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} | {
"id": "C0021270",
"name": "infants",
"pos": [
141,
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} |
a radical rearrangement of the organism occurred gradually : initially oval in shape , the parasite became round , then elongated , flattened , and underwent cytokinesis . | nichd_parent_of | {
"id": "C0029235",
"name": "organism",
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} | {
"id": "C0030498",
"name": "parasite",
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91,
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} |
at the basic level of the emotion hierarchy one finds the handful of concepts ( love , joy , anger , sadness , fear , and perhaps , surprise ) most useful for making everyday distinctions among emotions , and these overlap substantially with the examples mentioned most readily when people are asked to name emotions ( f... | nichd_parent_of | {
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"name": "people",
"pos": [
283,
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]
} | {
"id": "C0008059",
"name": "children",
"pos": [
363,
371
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} |
tumor is not always seen and particularly when there is no mass effect on macroscopic examination . | nichd_parent_of | {
"id": "C0027651",
"name": "tumor",
"pos": [
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5
]
} | {
"id": "C0577559",
"name": "mass",
"pos": [
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]
} |
sixteen patients with raynaud 's phenomenon ( 8 with primary raynaud 's , 8 with systemic sclerosis including 3 patients with crest ) were treated for 4 weeks in a double blind crossover study with nifedipine , 20 mg twice daily . | nichd_parent_of | {
"id": "C0034735",
"name": "raynaud 's phenomenon",
"pos": [
22,
43
]
} | {
"id": "C0151445",
"name": "primary raynaud 's",
"pos": [
53,
71
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} |
evaluation of patient history and physical examination are necessary , as well as delineation of the anatomy and function of the upper and lower tracts by laboratory , radiological and urodynamic examinations . | nichd_parent_of | {
"id": "C0220825",
"name": "evaluation",
"pos": [
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10
]
} | {
"id": "C0031809",
"name": "physical examination",
"pos": [
34,
54
]
} |
of those injuries not requiring immediate surgical repair perforations within the pelvis ( 6 of 11 ) led to strictures more often than those beyond the pelvis ( 1 of 9 ) . | nichd_parent_of | {
"id": "C3263723",
"name": "injuries",
"pos": [
9,
17
]
} | {
"id": "C0549099",
"name": "perforations",
"pos": [
58,
70
]
} |
to address this issue we evaluated 22 patients with clinical stage i testis tumors on a surveillance protocol with history , physical examination and semen analysis . | nichd_parent_of | {
"id": "C0220825",
"name": "evaluated",
"pos": [
25,
34
]
} | {
"id": "C0031809",
"name": "physical examination",
"pos": [
125,
145
]
} |
none of the normal subjects had late potentials and patients with ventricular arrhythmias but no organic heart diseases , also had no late potentials as well as patients with idiopathic ventricular tachycardias . | nichd_parent_of | {
"id": "C0085612",
"name": "ventricular arrhythmias",
"pos": [
66,
89
]
} | {
"id": "C0042514",
"name": "ventricular tachycardias",
"pos": [
186,
210
]
} |
we believe that the presence of a large amount of fatty tissue within the myocardial tissue is an important element in the etiology of ventricular arrhythmias as it has also been recognized in patients with non-arvd idiopathic ventricular tachycardia in our biopsy series . | nichd_parent_of | {
"id": "C0085612",
"name": "ventricular arrhythmias",
"pos": [
135,
158
]
} | {
"id": "C0042514",
"name": "ventricular",
"pos": [
227,
238
]
} |
a 7.5-year prospective study of ischemic heart disease ( myocardial infarction + angina pectoris on effort + sudden death ) among residents 40 years and older was conducted at a rural community , akadani-ijimino district in niigata prefecture . | nichd_parent_of | {
"id": "C0018799",
"name": "of",
"pos": [
29,
31
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
57,
78
]
} |
in summarizing the reports regarding cellular immunity in the household contacts of patients with malignant tumors , household contacts of patients with neuroblastoma , ostegenic sarcoma , malignant melanoma , breast cancer and colonic cancer demonstrated significantly higher reactivity against tumor associated antigen... | nichd_parent_of | {
"id": "C0006826",
"name": "malignant tumors",
"pos": [
98,
114
]
} | {
"id": "C1261473",
"name": "sarcoma",
"pos": [
179,
186
]
} |
in summarizing the reports regarding cellular immunity in the household contacts of patients with malignant tumors , household contacts of patients with neuroblastoma , ostegenic sarcoma , malignant melanoma , breast cancer and colonic cancer demonstrated significantly higher reactivity against tumor associated antigen... | nichd_parent_of | {
"id": "C0006826",
"name": "malignant tumors",
"pos": [
98,
114
]
} | {
"id": "C0025202",
"name": "malignant melanoma",
"pos": [
189,
207
]
} |
in summarizing the reports regarding cellular immunity in the household contacts of patients with malignant tumors , household contacts of patients with neuroblastoma , ostegenic sarcoma , malignant melanoma , breast cancer and colonic cancer demonstrated significantly higher reactivity against tumor associated antigen... | nichd_parent_of | {
"id": "C0006826",
"name": "malignant tumors",
"pos": [
98,
114
]
} | {
"id": "C0007134",
"name": "hypernephroma",
"pos": [
345,
358
]
} |
we have investigated the sensitivities of lymphocytes from inherited-cancer-prone diseases to the induction of the chromosome alterations by mutagens and carcinogens , and the correlations between the frequency of sister chromatid exchanges ( sces ) in peripheral lymphocytes and life-styles or daily ways of living . | nichd_parent_of | {
"id": "C0019247",
"name": "inherited",
"pos": [
59,
68
]
} | {
"id": "C0008625",
"name": "chromosome alterations",
"pos": [
115,
137
]
} |
neither contact control lambs nor control lambs that received ultrafiltered lung fluid developed evidence of either disease or of ovlv infection . | nichd_parent_of | {
"id": "C0012634",
"name": "disease",
"pos": [
116,
123
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
135,
144
]
} |
thirty-five patients had overt clinical manifestations of renal disease characterized by a nephrotic syndrome with focal and segmental glomerular sclerosis ( fss ) . | nichd_parent_of | {
"id": "C0022658",
"name": "renal disease",
"pos": [
58,
71
]
} | {
"id": "C0027726",
"name": "nephrotic syndrome",
"pos": [
91,
109
]
} |
ninety patients ( 37 males and 53 females ) with newly diagnosed , resected stage i cutaneous mm , levels iii and iv , were evaluated for metastatic disease at diagnosis using a physical examination ; | nichd_parent_of | {
"id": "C0220825",
"name": "evaluated",
"pos": [
124,
133
]
} | {
"id": "C0031809",
"name": "physical examination",
"pos": [
178,
198
]
} |
the body composition and anthropometric characteristics of male paraplegic athletes ( para , n = 22 ) were contrasted to an able-bodied ectomorphic ( n = 22 ) and mesomorphic ( n = 31 ) comparison group of moderately and highly trained male subjects . | nichd_parent_of | {
"id": "C1521970",
"name": "characteristics",
"pos": [
40,
55
]
} | {
"id": "C0030563",
"name": "para",
"pos": [
86,
90
]
} |
food intake during childhood : percentiles of food energy , macronutrient and selected micronutrients from infancy to eight years of age . | nichd_parent_of | {
"id": "C0231335",
"name": "childhood",
"pos": [
19,
28
]
} | {
"id": "C0231330",
"name": "infancy",
"pos": [
107,
114
]
} |
it is generally a self-limiting disorder , but severe infection may result in a 5 % mortality . | nichd_parent_of | {
"id": "C0012634",
"name": "disorder",
"pos": [
32,
40
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
54,
63
]
} |
ankylosing spondylitis , indefinite juvenile spondyloarthritis ( jsa ) , reactive arthritides , psoriasis arthritis , arthritis of inflammatory bowel disease , and probably other rare diseases , such as the behcet-syndrome , are sharing several distinctive features which discriminate them as a group from other arthriti... | nichd_parent_of | {
"id": "C0003864",
"name": "arthritis",
"pos": [
53,
62
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
348,
368
]
} |
in the differential diagnosis of arthritis in children , one third do have a spondyloarthritis and about one half do have jra . | nichd_parent_of | {
"id": "C0003864",
"name": "arthritis",
"pos": [
33,
42
]
} | {
"id": "C0949690",
"name": "spondyloarthritis",
"pos": [
77,
94
]
} |
17 of the children with a localized illness survive disease free in contrast to no survivor in the group with a disseminated tumor . | nichd_parent_of | {
"id": "C0012634",
"name": "disease",
"pos": [
52,
59
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
125,
130
]
} |
the locus also codes for glycoproteins which are abundant in several other normal epithelial tissues and body fluids , including milk , and in tumours of epithelial origin . | nichd_parent_of | {
"id": "C0005889",
"name": "body fluids",
"pos": [
105,
116
]
} | {
"id": "C0026131",
"name": "milk",
"pos": [
129,
133
]
} |
a one stage operation performed by a triple retromastoid , transpetrous and retroparotid approach , allowed a complete removal . | nichd_parent_of | {
"id": "C0543467",
"name": "operation",
"pos": [
12,
21
]
} | {
"id": "C0015250",
"name": "complete removal",
"pos": [
110,
126
]
} |
behavioural alterations produced by the administration of sodium valproate at 600 mg/l as drinking fluid during pregnancy and lactation ( group svp ) , and during lactation only , ( group pn ) were assessed . | nichd_parent_of | {
"id": "C0004927",
"name": "behavioural",
"pos": [
0,
11
]
} | {
"id": "C0006147",
"name": "lactation",
"pos": [
163,
172
]
} |
dams of group pn showed behavioural differences from controls in late lactation , pup nursing being prolonged at day 14 postpartum and the frequency of all categories of active behaviour , other than nursing and nestbuilding , was increased at day 21 postpartum in the dark phase of their daily cycle . | nichd_parent_of | {
"id": "C0004927",
"name": "behaviour",
"pos": [
24,
33
]
} | {
"id": "C0006147",
"name": "nursing",
"pos": [
200,
207
]
} |
seeding of the cyst cavity could have occurred by direct permeation of the cyst wall by the neoplastic glial cells spreading via the cerebrospinal fluid or by direct access of the cells through a defect in the arachnoid cyst wall and their subsequent entrapment by a ball valve type mechanism , leading to multiple impla... | nichd_parent_of | {
"id": "C0010709",
"name": "cyst",
"pos": [
15,
19
]
} | {
"id": "C0078981",
"name": "arachnoid cyst",
"pos": [
210,
224
]
} |
disorders of the blood coagulation system in acute gastro-enteritis in infants with no clinical manifestations of coagulopathy . | nichd_parent_of | {
"id": "C0018939",
"name": "disorders of the blood",
"pos": [
0,
22
]
} | {
"id": "C0005779",
"name": "coagulopathy",
"pos": [
114,
126
]
} |
if properly prepared , those individuals responsible for the emergency treatment of children should be able to save a high percentage of children who suffer injuries to the airway and thorax . | nichd_parent_of | {
"id": "C0027361",
"name": "individuals",
"pos": [
29,
40
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
137,
145
]
} |
to investigate a possible protective role of htlv-iii neutralizing antibodies in individuals exposed to the virus , sera of children with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex were analyzed for neutralizability of htlv-iiib infectivity . | nichd_parent_of | {
"id": "C0027361",
"name": "individuals",
"pos": [
81,
92
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
124,
132
]
} |
to determine whether there was a difference in the altered cellular immune responses of children with and without complications we performed a prospective study of purified protein derivative skin test reactivity in children with natural measles virus infections who had received bacillus calmette-guerin as infants . | nichd_parent_of | {
"id": "C0008059",
"name": "children",
"pos": [
88,
96
]
} | {
"id": "C0021270",
"name": "infants",
"pos": [
308,
315
]
} |
nine children with the williams syndrome were evaluated for physical , neurodevelopmental , and behavioral characteristics to record the natural history of this disorder . | nichd_parent_of | {
"id": "C0220825",
"name": "evaluated",
"pos": [
46,
55
]
} | {
"id": "C0031809",
"name": "physical",
"pos": [
60,
68
]
} |
for dscarna 5 two characteristic transitions were detected with increasing temperature : at temperatures between 40 degrees c and 46 degrees c a drastic retardation in electrophoretic mobility induced by partial dissociation of the duplex structure from the ends and at temperatures above 52 degrees c an abrupt increase... | nichd_parent_of | {
"id": "C1521970",
"name": "characteristic",
"pos": [
18,
32
]
} | {
"id": "C0039476",
"name": "temperatures",
"pos": [
270,
282
]
} |
provided patients are better selected and the procedure is used mainly for cholangiocarcinomas , we see no reason why the transhepatic route ( combined , if necessary , with endoscopy ) should no longer be used to introduce biliary endoprostheses . | nichd_parent_of | {
"id": "C0184661",
"name": "procedure",
"pos": [
46,
55
]
} | {
"id": "C0013153",
"name": "route",
"pos": [
135,
140
]
} |
in this paper evidence is explored to support developmental linkages between these disorders in adults and disorders in childhood and adolescence . | nichd_parent_of | {
"id": "C0231335",
"name": "childhood",
"pos": [
120,
129
]
} | {
"id": "C0001578",
"name": "adolescence",
"pos": [
134,
145
]
} |
the sequence of host-defense against microbial invasion consists of nonspecific active substances which are distributed diffusely in the body fluids and exert their functions quickly to eliminate microorganisms , nonspecific humoral elements capable of exerting their functions selectively at the site of microbial invas... | nichd_parent_of | {
"id": "C0439861",
"name": "substances",
"pos": [
87,
97
]
} | {
"id": "C0005889",
"name": "body fluids",
"pos": [
137,
148
]
} |
we have developed a behavioral paradigm of chronic stress which incorporates sustained stress , continuous performance , and disruption of sleep . | nichd_parent_of | {
"id": "C0004927",
"name": "behavioral",
"pos": [
20,
30
]
} | {
"id": "C0037313",
"name": "sleep",
"pos": [
139,
144
]
} |
thirteen to 14 days postinoculation the affected rats showed peak clinical signs of weakness , especially in the lower extremities . | nichd_parent_of | {
"id": "C3540840",
"name": "clinical signs",
"pos": [
66,
80
]
} | {
"id": "C3714552",
"name": "weakness",
"pos": [
84,
92
]
} |
the diffuse obstructive and infiltrative lung diseases ( e.g . bronchitis , asthmatic bronchitis , fibrosing alveolitis , sarcoidosis ) contribute significantly to human morbidity and mortality . | nichd_parent_of | {
"id": "C0024115",
"name": "lung diseases",
"pos": [
41,
54
]
} | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
86,
96
]
} |
[ diagnosis and therapy of skeletal infections from the orthopedic viewpoint . arthritis , infant osteomyelitis , hematogenous and post-traumatic osteomyelitis , spondylitis , infected endoprosthesis ] . | nichd_parent_of | {
"id": "C0003864",
"name": "arthritis",
"pos": [
79,
88
]
} | {
"id": "C0038012",
"name": "spondylitis",
"pos": [
162,
173
]
} |
it is proposed that the causative agent of leprosy is not a difficult-to-transmit agent but , rather , an organism that has evolved a highly efficient state of parasitism in stable types of populations and that everyone in the population harbors the leprosy parasite at some time . | nichd_parent_of | {
"id": "C0029235",
"name": "organism",
"pos": [
106,
114
]
} | {
"id": "C0030498",
"name": "parasite",
"pos": [
258,
266
]
} |
all but two neoplasms showed positivity for placental alkaline phosphatase , thus supporting its reliability as a marker of germ-cell tumours . | nichd_parent_of | {
"id": "C0027651",
"name": "neoplasms",
"pos": [
12,
21
]
} | {
"id": "C0205851",
"name": "of germ-cell tumours",
"pos": [
121,
141
]
} |
although the major cerebellar cell classes are well known , a new class of cerebellar cortical neuron has now been identified with a monoclonal antibody ( mab ) generated by a procedure for rapid immunization and selective immunosuppression of antibody responses . | nichd_parent_of | {
"id": "C0184661",
"name": "procedure",
"pos": [
176,
185
]
} | {
"id": "C0020971",
"name": "immunization",
"pos": [
196,
208
]
} |
new blood vessel growth occurs during normal fetal development and in diseases such as cancer and diabetes . | nichd_parent_of | {
"id": "C0027651",
"name": "new",
"pos": [
0,
3
]
} | {
"id": "C0006826",
"name": "cancer",
"pos": [
87,
93
]
} |
two patients had no detectable granulomas at muscle biopsy and may represent a separate autoimmune disorder ( polymyositis ) concurrent with sarcoidosis . | nichd_parent_of | {
"id": "C0004364",
"name": "autoimmune disorder",
"pos": [
88,
107
]
} | {
"id": "C0036202",
"name": "sarcoidosis",
"pos": [
141,
152
]
} |
other neoplasms that have been described in hiv-infected individuals include cloacogenic anorectal carcinoma and squamous-cell carcinoma of the head , neck , and oral cavity , but there is currently no epidemiologic evidence to prove that these cancers are part of the spectrum of aids . | nichd_parent_of | {
"id": "C0027651",
"name": "neoplasms",
"pos": [
6,
15
]
} | {
"id": "C0006826",
"name": "cancers",
"pos": [
245,
252
]
} |
there are , however , important differences in the pathogenesis of the disease in the different groups affected by the neoplasm . | nichd_parent_of | {
"id": "C0012634",
"name": "disease",
"pos": [
71,
78
]
} | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
119,
127
]
} |
applying the rules will result in condemnation of animals harbouring a small number of bacteria which have a minimum significance for the health of consumers , whereas animals harbouring organisms potentially pathogenic for man are overlooked . | nichd_parent_of | {
"id": "C0029235",
"name": "organisms",
"pos": [
187,
196
]
} | {
"id": "C0450254",
"name": "pathogenic",
"pos": [
209,
219
]
} |
with reference to the stage-grade system , the dna aneuploidy rate increased significantly from tumors with increasing degree of malignancy . | nichd_parent_of | {
"id": "C0027651",
"name": "tumors",
"pos": [
96,
102
]
} | {
"id": "C0006826",
"name": "malignancy",
"pos": [
129,
139
]
} |
these results demonstrate that although an occasional coagulation abnormality may occur in patients with cancer of the prostate ( albeit with a lower incidence than in other neoplasms ) , this malignancy does not require increased precautions with respect to those given to the patient population at large . | nichd_parent_of | {
"id": "C0027651",
"name": "neoplasms",
"pos": [
174,
183
]
} | {
"id": "C0006826",
"name": "malignancy",
"pos": [
193,
203
]
} |
brains , spinal cords , nerve roots , nerves and muscle tissues were removed from deer in southern new york state and examined for histologic evidence of infection by the causative agent of lyme disease , borrelia burgdorferi . | nichd_parent_of | {
"id": "C0009450",
"name": "infection",
"pos": [
154,
163
]
} | {
"id": "C0024198",
"name": "lyme disease",
"pos": [
190,
202
]
} |
these results suggest that there is a difference between the vaccines used and between the responses of the two species and support the clinical observation that the protection afforded to goats by multivalent clostridial vaccines is poorer than that afforded to sheep . | nichd_parent_of | {
"id": "C0042210",
"name": "vaccines",
"pos": [
61,
69
]
} | {
"id": "C1514218",
"name": "multivalent",
"pos": [
198,
209
]
} |
the suppressive slifs in sera from clinically healthy dogs and from dogs with bacterial ( staphylococcal , brucellar ) or mycotic ( blastomycotic ) infections were further characterized by dialysis , fractionation by ultrafiltrations and hplc ( high performance liquid chromatography ) sieving , by affinity chromatograp... | nichd_parent_of | {
"id": "C0026946",
"name": "mycotic",
"pos": [
122,
129
]
} | {
"id": "C0005716",
"name": "blastomycotic",
"pos": [
132,
145
]
} |
immunized animals were fully protected from disease , using a bhv-1/pasteurella haemolytica aerosol challenge model but not from infection with the virus . | nichd_parent_of | {
"id": "C0012634",
"name": "disease",
"pos": [
44,
51
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
129,
138
]
} |
the procedure developed might be used in chemical industry for evaluation of toxic effects of some substances . | nichd_parent_of | {
"id": "C0184661",
"name": "procedure",
"pos": [
4,
13
]
} | {
"id": "C0220825",
"name": "evaluation",
"pos": [
63,
73
]
} |
the characteristics of angina in regard to their localisation , length of time , time of occurrence , provocation and influence by drugs are described . | nichd_parent_of | {
"id": "C1521970",
"name": "characteristics",
"pos": [
4,
19
]
} | {
"id": "C1444754",
"name": "length",
"pos": [
64,
70
]
} |
the underlying cardiac disease was coronary heart disease in 11 patients and cardiomyopathy in 2 cases . | nichd_parent_of | {
"id": "C0018799",
"name": "cardiac disease",
"pos": [
15,
30
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
77,
91
]
} |
of the primary cns tumors keratin positivity occurred in craniopharyngiomas , epidermoid tumors , pituitary adenomas , chordomas , a plexus papilloma as well as in the majority of germ cell tumors . | nichd_parent_of | {
"id": "C0027651",
"name": "tumors",
"pos": [
19,
25
]
} | {
"id": "C0032000",
"name": "pituitary adenomas",
"pos": [
98,
116
]
} |
of the primary cns tumors keratin positivity occurred in craniopharyngiomas , epidermoid tumors , pituitary adenomas , chordomas , a plexus papilloma as well as in the majority of germ cell tumors . | nichd_parent_of | {
"id": "C0027651",
"name": "tumors",
"pos": [
19,
25
]
} | {
"id": "C0205851",
"name": "the",
"pos": [
164,
167
]
} |
within three different sub-categories of chd only cases ending-up as sudden deaths were significantly related to the three factors including smoking habits , whereas those manifested as myocardial infarction ( without sudden death ) and those manifested as chronic coronary heart disease ( atypical chd ) were related on... | nichd_parent_of | {
"id": "C0018799",
"name": "of chd",
"pos": [
38,
44
]
} | {
"id": "C0027051",
"name": "myocardial",
"pos": [
186,
196
]
} |
three of these abscesses probably were attributable to complications of surgery as such , leaving one intraabdominal abscess in each group . | nichd_parent_of | {
"id": "C0000833",
"name": "abscesses",
"pos": [
15,
24
]
} | {
"id": "C0243001",
"name": "intraabdominal abscess",
"pos": [
102,
124
]
} |
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