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BioRel

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there was , however , no significant difference between treatment groups , whether assessed by improvement in specific organ involvement , improvement in the overall grade of gvhd , need for additional therapy for acute gvhd , or the proportion of patients who developed chronic gvhd .
nichd_parent_of
{ "id": "C0018133", "name": "gvhd", "pos": [ 175, 179 ] }
{ "id": "C0856825", "name": "acute gvhd", "pos": [ 214, 224 ] }
there was , however , no significant difference between treatment groups , whether assessed by improvement in specific organ involvement , improvement in the overall grade of gvhd , need for additional therapy for acute gvhd , or the proportion of patients who developed chronic gvhd .
nichd_parent_of
{ "id": "C0018133", "name": "gvhd", "pos": [ 175, 179 ] }
{ "id": "C0867389", "name": "chronic", "pos": [ 271, 278 ] }
a careful evaluation , including a therapeutic trial of oral iron in some subjects , made a diagnosis of iron deficiency anemia in only three and the anemia of chronic disease could be diagnosed in two .
nichd_parent_of
{ "id": "C0002871", "name": "anemia", "pos": [ 121, 127 ] }
{ "id": "C0002873", "name": "anemia of chronic disease", "pos": [ 150, 175 ] }
these results confirmed the findings of valentine et al [ 1 ] that lead-induced deficiency of p5n resulted in basophilic stippling and hemolytic anemia just like hereditary hemolytic anemia due to p5n deficiency .
nichd_parent_of
{ "id": "C0002878", "name": "hemolytic anemia", "pos": [ 135, 151 ] }
{ "id": "C0002881", "name": "hemolytic anemia", "pos": [ 173, 189 ] }
the findings , indicated that during the school year , 10 percent of the students received medication for seizure disorders and 4.9 percent were treated for behavior disorders .
nichd_parent_of
{ "id": "C0012634", "name": "disorders", "pos": [ 114, 123 ] }
{ "id": "C0004930", "name": "behavior disorders", "pos": [ 157, 175 ] }
in most cases they can suggest more than one instrument which would be of benefit dentally to the individual child , especially in the increase or reduction of overjet and overbite .
nichd_parent_of
{ "id": "C0027361", "name": "individual", "pos": [ 98, 108 ] }
{ "id": "C0008059", "name": "child", "pos": [ 109, 114 ] }
the authors studied whether skin temperature training ( biofeedback ) reduces the frequency , severity , and duration of these headaches by measuring the regional cerebral blood flow in 11 migraine patients and 9 normal volunteers using the noninvasive 133xe inhalation technique .
nichd_parent_of
{ "id": "C0018681", "name": "headaches", "pos": [ 127, 136 ] }
{ "id": "C0149931", "name": "migraine", "pos": [ 189, 197 ] }
the most common clinical signs in affected dogs were dyspnea , abdominal distention by ascites , and weight loss .
nichd_parent_of
{ "id": "C3540840", "name": "clinical", "pos": [ 16, 24 ] }
{ "id": "C0013404", "name": "dyspnea", "pos": [ 53, 60 ] }
the most common clinical signs in affected dogs were dyspnea , abdominal distention by ascites , and weight loss .
nichd_parent_of
{ "id": "C3540840", "name": "clinical", "pos": [ 16, 24 ] }
{ "id": "C0003962", "name": "ascites", "pos": [ 87, 94 ] }
the clinical signs of toxicosis observed in horses given either drug were progressive and included depression , ataxia , paresis , and paralysis with partial anorexia .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 4, 18 ] }
{ "id": "C0003123", "name": "anorexia", "pos": [ 158, 166 ] }
to determine factors influencing the iga concentration in swine colostrum , the following items were analyzed in the present study : season , district , breed , number of parturitions , udder section from which samples were collected , kind of feed , vaccinations of swine ( erysipelas live-organism vaccine , hog choler...
nichd_parent_of
{ "id": "C0029235", "name": "organism", "pos": [ 291, 299 ] }
{ "id": "C0042776", "name": "virus", "pos": [ 425, 430 ] }
clinical signs of disease in the severely affected dogs were fever , dehydration , depression , and icterus .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0015967", "name": "fever", "pos": [ 61, 66 ] }
this finding indicates that on irrigated pastures in california , type i ostertagiasis can be expected to occur as the result of infection during the spring and/or fall peaks , whereas type ii ostertagiasis can be expected to occur in the fall as a result of infection obtained during the spring peak .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 5, 12 ] }
{ "id": "C0085639", "name": "fall", "pos": [ 239, 243 ] }
in autologous serum , adherence of pmn from patients with wide variety of untreated fungal infections , including blastomycosis , histoplasmosis , cryptococcosis , coccidiodomycosis , and spirotrichosis , was significantly ( p less than 0.001 ) decreased when compared with pmn from uninfected control subjects or patien...
nichd_parent_of
{ "id": "C0026946", "name": "fungal infections", "pos": [ 84, 101 ] }
{ "id": "C0005716", "name": "blastomycosis", "pos": [ 114, 127 ] }
in autologous serum , adherence of pmn from patients with wide variety of untreated fungal infections , including blastomycosis , histoplasmosis , cryptococcosis , coccidiodomycosis , and spirotrichosis , was significantly ( p less than 0.001 ) decreased when compared with pmn from uninfected control subjects or patien...
nichd_parent_of
{ "id": "C0026946", "name": "fungal infections", "pos": [ 84, 101 ] }
{ "id": "C0010414", "name": "cryptococcosis", "pos": [ 147, 161 ] }
such advances had permitted a better understanding of clinical conditions characterized by concentrating defects , including hyperkalemia , hypercalcemia , parenchymal renal disease , obstructive renal disease , and polyuria induced by certain drugs .
nichd_parent_of
{ "id": "C0022658", "name": "renal", "pos": [ 168, 173 ] }
{ "id": "C0149939", "name": "obstructive renal disease", "pos": [ 184, 209 ] }
no significant differences were noticed in the mortality rate ( one death after early operation , two after a delayed procedure ) , major morbidity rate ( in four and three patients , respectively ) , or in duration of the initial hospitalization period ( early operation : 13.5 days , delayed operation : 16.7 days ) .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 118, 127 ] }
{ "id": "C0543467", "name": "operation", "pos": [ 294, 303 ] }
of implanted sites that could be evaluated by physical examination , 31 of 31 were solid by three months .
nichd_parent_of
{ "id": "C0220825", "name": "evaluated", "pos": [ 33, 42 ] }
{ "id": "C0031809", "name": "physical", "pos": [ 46, 54 ] }
among 8 observations of progressing disease 7 tumors contained er and were of the ii and iii degree of malignancy .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 36, 43 ] }
{ "id": "C0027651", "name": "tumors", "pos": [ 46, 52 ] }
among 8 observations of progressing disease 7 tumors contained er and were of the ii and iii degree of malignancy .
nichd_parent_of
{ "id": "C0027651", "name": "tumors", "pos": [ 46, 52 ] }
{ "id": "C0006826", "name": "malignancy", "pos": [ 103, 113 ] }
these results suggest that the adult jaundiced gunn rat retains auditory function and in this way differs from human patients in whom neonatal jaundice has lead to hearing loss .
nichd_parent_of
{ "id": "C0022346", "name": "jaundiced", "pos": [ 37, 46 ] }
{ "id": "C0022353", "name": "neonatal jaundice", "pos": [ 134, 151 ] }
considering that a greater concentration of proteins in the meconium of children with pancreatic achylia has been reported , the possibility was set forth that a similar finding was present in infants with intrauterine malnutrition ;
nichd_parent_of
{ "id": "C0008059", "name": "children", "pos": [ 72, 80 ] }
{ "id": "C0021270", "name": "infants", "pos": [ 193, 200 ] }
data on these patients have been reviewed in order to estimate the number likely to need cardiac surgery during childhood and adolescence .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 112, 121 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 126, 137 ] }
deoxyribonucleoside triphosphate ( dntp ) concentrations were measured in bone marrow and peripheral blood leucocytes from seven patients with acute thy-lymphoblastic leukaemia ( thy-all ) , 12 patients with acute myeloblastic leukaemia and 15 patients with acute non-t , non-b lymphoblastic leukaemia ( c-all ) , and in...
nichd_parent_of
{ "id": "C0023449", "name": "acute", "pos": [ 143, 148 ] }
{ "id": "C1292769", "name": "c-all", "pos": [ 304, 309 ] }
among currently living organisms , the bacteria contain a much less complex photosynthetic system than the algae and higher plants , which uniquely are capable fo splitting h2o .
nichd_parent_of
{ "id": "C0029235", "name": "living organisms", "pos": [ 16, 32 ] }
{ "id": "C0004611", "name": "bacteria", "pos": [ 39, 47 ] }
a 9-yr-old female presented with a wilm 's tumor and a coagulopathy consistent with von willebrand 's disease .
nichd_parent_of
{ "id": "C0005779", "name": "coagulopathy", "pos": [ 55, 67 ] }
{ "id": "C0042974", "name": "von willebrand 's disease", "pos": [ 84, 109 ] }
the delorme procedure seems to be superior to the thiersch operation , and the postoperative mortality and morbidity is equally low .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 12, 21 ] }
{ "id": "C0543467", "name": "operation", "pos": [ 59, 68 ] }
spread of multiple-resistance plasmids among endemic gentamicin-resistant enterobacteria is not uncommon , and these organisms provide a reservoir of plasmids that may ultimately spread to more pathogenic genera .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 117, 126 ] }
{ "id": "C0450254", "name": "pathogenic", "pos": [ 194, 204 ] }
with limitations in drug total dose , a variety of dose schedules have proven to be tolerable , with a moderate incidence of nausea and vomiting and mild peripheral neuropathy , and a low incidence of more severe peripheral neuropathy or central neuropathy .
nichd_parent_of
{ "id": "C0031117", "name": "peripheral", "pos": [ 154, 164 ] }
{ "id": "C0442874", "name": "neuropathy", "pos": [ 246, 256 ] }
thirteen of the 15 patients with no known disease developed acute leukemia in from one to 49 months after the biopsy of their tumors ( mean 10 months ) .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 42, 49 ] }
{ "id": "C0027651", "name": "tumors", "pos": [ 126, 132 ] }
although the lack of specificity of these markers has limited their use in the diagnosis of gynecologic malignancies , they have been effective as a means of monitoring disease status in patients whose tumors contain high antigen concentrations .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 169, 176 ] }
{ "id": "C0027651", "name": "tumors", "pos": [ 202, 208 ] }
prognostic factors in small cell carcinoma of the lung : a cancer and leukemia group b study .
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 59, 65 ] }
{ "id": "C0023418", "name": "group", "pos": [ 79, 84 ] }
prognostic factors were studied in 224 patients with small cell carcinoma of the lung entered in a cancer and leukemia group b protocol .
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 99, 105 ] }
{ "id": "C0023418", "name": "group", "pos": [ 119, 124 ] }
eighteen out of 40 individuals ( 45 % ) in the families with fetal wastage were found to have cytogenetic abnormalities .
nichd_parent_of
{ "id": "C0027361", "name": "individuals", "pos": [ 19, 30 ] }
{ "id": "C0015965", "name": "fetal", "pos": [ 61, 66 ] }
the diseases studied were non-systemic renal immune complex diseases , systemic diseases with kidney involvement , renal diseases with minimal pathological changes and histological normal kidneys .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 4, 12 ] }
{ "id": "C0442893", "name": "systemic diseases", "pos": [ 71, 88 ] }
the incidence of antibody to nucleic acids , polyadenylic-polyuridylic acid , polyinosinic-polycytidylic acid , single-stranded dna and anti-nuclear antibody was significantly higher in the low-dose group as compared to the high-dose group or controls ( p less than 0.01 ) .
nichd_parent_of
{ "id": "C0003241", "name": "antibody", "pos": [ 17, 25 ] }
{ "id": "C0003243", "name": "anti-nuclear antibody", "pos": [ 136, 157 ] }
the infection readily responded to removal of the foreign body , debridement of the abscess , and treatment with appropriate antibiotics .
nichd_parent_of
{ "id": "C0009450", "name": "infection", "pos": [ 4, 13 ] }
{ "id": "C0000833", "name": "abscess", "pos": [ 84, 91 ] }
this report describes the procedures and feasibility of an integrated evaluation and training program developed at the baylor-methodist lipid research clinic to examine the skills used by the clinic 's professional staff in conducting medication adherence interviews with participants in the coronary primary prevention ...
nichd_parent_of
{ "id": "C0184661", "name": "procedures", "pos": [ 26, 36 ] }
{ "id": "C0220825", "name": "evaluation", "pos": [ 70, 80 ] }
also , they are immensely useful in studies related to various diseases and disorders , particularly cardiovascular diseases and obesity .
nichd_parent_of
{ "id": "C0012634", "name": "disorders", "pos": [ 76, 85 ] }
{ "id": "C0007222", "name": "cardiovascular diseases", "pos": [ 101, 124 ] }
narcoleptic patients also frequently complain of hypnagogic hallucinations , sleep paralysis , and automatic behavior , as well as disturbed nocturnal sleep .
nichd_parent_of
{ "id": "C0004927", "name": "behavior", "pos": [ 109, 117 ] }
{ "id": "C0037313", "name": "sleep", "pos": [ 151, 156 ] }
diversion techniques for distal intraduodenal cysts leads to development of the sump syndrome , and , it has been our experience in two patients to treat these , choledochocele , by incision during performance of a sphincterotomy .
nichd_parent_of
{ "id": "C0010709", "name": "cysts", "pos": [ 46, 51 ] }
{ "id": "C0008340", "name": "choledochocele", "pos": [ 162, 176 ] }
the parenteral routes used were intravenous injection , intraperitoneal injection , subcutaneous implantation , as well as intrafemoral and intramuscular injection .
nichd_parent_of
{ "id": "C1518896", "name": "parenteral routes", "pos": [ 4, 21 ] }
{ "id": "C0021492", "name": "intramuscular injection", "pos": [ 140, 163 ] }
the endpoints of the carcinogenic reactions are , in the main , sarcomas of certain types with fibrosarcomas predominating .
nichd_parent_of
{ "id": "C1261473", "name": "sarcomas", "pos": [ 64, 72 ] }
{ "id": "C0016057", "name": "fibrosarcomas", "pos": [ 95, 108 ] }
the most common dermatoses were pediculosis ( prevalence 50 % ) , nevi ( 16.8 % ) , pityriasis versicolor ( 13.2 % ) , pyoderma ( 12.2 % ) , pityriasis alba ( 9.9 % ) , dermatophytosis ( 6.2 % ) , viral dermatosis ( 6.2 % ) , scabies ( 3.0 % ) and acne vulgaris ( 2.7 % ) .
nichd_parent_of
{ "id": "C0037274", "name": "dermatoses", "pos": [ 16, 26 ] }
{ "id": "C0040262", "name": "pityriasis versicolor", "pos": [ 84, 105 ] }
the most common dermatoses were pediculosis ( prevalence 50 % ) , nevi ( 16.8 % ) , pityriasis versicolor ( 13.2 % ) , pyoderma ( 12.2 % ) , pityriasis alba ( 9.9 % ) , dermatophytosis ( 6.2 % ) , viral dermatosis ( 6.2 % ) , scabies ( 3.0 % ) and acne vulgaris ( 2.7 % ) .
nichd_parent_of
{ "id": "C0037274", "name": "dermatoses", "pos": [ 16, 26 ] }
{ "id": "C0001144", "name": "acne", "pos": [ 248, 252 ] }
climatic conditions might have enhanced the prevalence of certain dermatoses ( pityriasis versicolor , dermatophytosis , piedra nigra , candidiasis , miliaria rubra ) .
nichd_parent_of
{ "id": "C0037274", "name": "dermatoses", "pos": [ 66, 76 ] }
{ "id": "C0040262", "name": "pityriasis versicolor", "pos": [ 79, 100 ] }
ten of the patients had had uncomplicated abdominal surgery two of five days before , six patients had moderate sepsis e.g . wound sepsis and nine patients had severe intra-abdominal sepsis .
nichd_parent_of
{ "id": "C0036690", "name": "sepsis", "pos": [ 112, 118 ] }
{ "id": "C1719672", "name": "severe", "pos": [ 160, 166 ] }
the recent advent of high resolution chromosome techniques for the study of neoplasia has conceivably expanded the scope of cancer cytogenetics , making feasible the detection of chromosomal defects in most neoplasias .
nichd_parent_of
{ "id": "C0027651", "name": "neoplasia", "pos": [ 76, 85 ] }
{ "id": "C0006826", "name": "cancer", "pos": [ 124, 130 ] }
this association of a blocking activity with clinical condition may signal a transition point in the progression of cystic fibrosis lung disease and thus may be another contributory factor in the failure of the cystic fibrosis host to control infection .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 137, 144 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 243, 252 ] }
indirect immunoperoxidase staining showed that antibody to flagellin isolated from serogroup 1 organisms reacted with flagella on serogroup 1 , 2 , and 3 bacteria .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 95, 104 ] }
{ "id": "C0004611", "name": "bacteria", "pos": [ 154, 162 ] }
inter-individual differences in oxidative benzo ( a ) pyrene metabolism by normal and tumorous surgical lung specimens from 105 lung cancer patients .
nichd_parent_of
{ "id": "C0027651", "name": "tumorous", "pos": [ 86, 94 ] }
{ "id": "C0006826", "name": "cancer", "pos": [ 133, 139 ] }
the survival of 20 children with medulloblastoma who received adjuvant chemotherapy with procarbazine , vincristine and prednisone after resection and craniospinal irradiation is compared with the preliminary results of the children 's cancer study group ( ccsg ) and the international society of pediatric oncology ( si...
nichd_parent_of
{ "id": "C0025149", "name": "medulloblastoma", "pos": [ 33, 48 ] }
{ "id": "C0278510", "name": "pediatric", "pos": [ 297, 306 ] }
based on the criteria previously defined it was found that all the cell lines were proved to represent original leukemia-lymphoma of all , aml , cll , cml in blastic phase or variety of lymphomas .
nichd_parent_of
{ "id": "C0023418", "name": "lymphoma", "pos": [ 121, 129 ] }
{ "id": "C0023467", "name": "aml", "pos": [ 139, 142 ] }
during an outbreak of neonatal meningitis caused by kanamycin-resistant citrobacter diversus , a field procedure for presumptive identification of the organism was evaluated , and using it resulted in the early recognition of patients colonized by the epidemic strain of c. diversus .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 103, 112 ] }
{ "id": "C0220825", "name": "evaluated", "pos": [ 164, 173 ] }
virus counts and endpoint titrations of serial dilutions of partially purified preparations of poliovirus , sa11 rotavirus , herpes simplex virus , and vaccinia virus showed an increase of ca .
nichd_parent_of
{ "id": "C0042776", "name": "virus", "pos": [ 0, 5 ] }
{ "id": "C0206435", "name": "poliovirus", "pos": [ 95, 105 ] }
virus counts and endpoint titrations of serial dilutions of partially purified preparations of poliovirus , sa11 rotavirus , herpes simplex virus , and vaccinia virus showed an increase of ca .
nichd_parent_of
{ "id": "C0042776", "name": "virus", "pos": [ 0, 5 ] }
{ "id": "C0035870", "name": "rotavirus", "pos": [ 113, 122 ] }
a 125i-radioimmunoassay procedure and capillary gas liquid chromatography-mass spectrometry have been used in this investigation to measure serum bile salt concentrations in premature and normal term infants .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 24, 33 ] }
{ "id": "C0220825", "name": "investigation", "pos": [ 115, 128 ] }
the clinician should understand the significance of each finding and investigate them until a confirmatory diagnosis is made .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 57, 64 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 107, 116 ] }
treatment with cortisone derivatives resulted in 56 pregnancies , which were studied to their term whether it was abortion or delivery .
nichd_parent_of
{ "id": "C0032972", "name": "resulted", "pos": [ 37, 45 ] }
{ "id": "C0233324", "name": "term", "pos": [ 94, 98 ] }
treatment with cortisone derivatives resulted in 56 pregnancies , which were studied to their term whether it was abortion or delivery .
nichd_parent_of
{ "id": "C0032972", "name": "resulted", "pos": [ 37, 45 ] }
{ "id": "C0156543", "name": "abortion", "pos": [ 114, 122 ] }
induction in this way is really efficacious , and the labour that is the result is comparable to spontaneous labours .
nichd_parent_of
{ "id": "C0022864", "name": "labour", "pos": [ 54, 60 ] }
{ "id": "C0474461", "name": "spontaneous labours", "pos": [ 97, 116 ] }
the influence of genetic factors on the manifestations of disease associated with infection with schistosoma mansoni ( portal hypertension , liver granulomas , hepatosplenomegaly ) and their modulation were studied in inbred strains of mice .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 58, 65 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 82, 91 ] }
these data indicate that disease associated with infection with s. mansoni and its modulation in mice are influenced by the genetic ( non-h-2 ) background of the host and dependent in part on cell-mediated immunity .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 25, 32 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 49, 58 ] }
stool specimens were examined for viruses by electron microscopy and cultured for enteropathogens , and serum specimens were tested for antibodies to rotavirus and norwalk virus .
nichd_parent_of
{ "id": "C0042776", "name": "viruses", "pos": [ 34, 41 ] }
{ "id": "C0035870", "name": "rotavirus", "pos": [ 150, 159 ] }
the clinical and histological appearance of type ii collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis .
nichd_parent_of
{ "id": "C0003864", "name": "arthritis", "pos": [ 61, 70 ] }
{ "id": "C0003873", "name": "rheumatoid arthritis", "pos": [ 186, 206 ] }
these organisms should not be dismissed as contaminants or `` '' non-pathogens , '' '' particularly when isolated from csf of patients who have recently undergone neurosurgical procedures .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 6, 15 ] }
{ "id": "C0450254", "name": "-pathogen", "pos": [ 68, 77 ] }
indium-111 bledta , a bleomycin analog containing an edta group , was used for tumor imaging in 110 patients with cancer .
nichd_parent_of
{ "id": "C0027651", "name": "tumor", "pos": [ 79, 84 ] }
{ "id": "C0006826", "name": "cancer", "pos": [ 114, 120 ] }
kittens fed either the 9.0 % followed by the 12.0 % glutamate diets or vice versa developed severe clinical signs of thiamin deficiency and two kittens died .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 99, 113 ] }
{ "id": "C0011065", "name": "died", "pos": [ 152, 156 ] }
evaluation of a child with goiter includes historical review , physical examination , and measurement of serum concentrations of pbi , t4 and t3ru , tsh , and titers of antithyroglobulin and antithyroid microsomal antibodies .
nichd_parent_of
{ "id": "C0220825", "name": "evaluation", "pos": [ 0, 10 ] }
{ "id": "C0031809", "name": "physical", "pos": [ 63, 71 ] }
one has survived free of disease at 6 yr after treatment with vac and adriamycin and pelvic rt , but the other 5 died of tumor ( 2 ) or of pneumonia after pulmonary rt ( 3 ) .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 25, 32 ] }
{ "id": "C0027651", "name": "tumor", "pos": [ 121, 126 ] }
the heterozygote frequency for the friedreich 's ataxia gene is in the order of 1 in 110 , so the likelihood of the disease developing in an individual child of a patient is 1 in 220 .
nichd_parent_of
{ "id": "C0027361", "name": "individual", "pos": [ 141, 151 ] }
{ "id": "C0008059", "name": "child", "pos": [ 152, 157 ] }
a bizarre syndrome has hitherto masqueraded as leprechaunism , and although it is a quite different disorder it has been used as the prototype of leprechaunism in some birth defects atlases .
nichd_parent_of
{ "id": "C0039082", "name": "syndrome", "pos": [ 10, 18 ] }
{ "id": "C0265344", "name": "leprechaunism", "pos": [ 146, 159 ] }
the variety of mycotic and bacterial organisms identified , however , suggests that the compromise of the host is the critical factor , and not any particular microorganism .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 37, 46 ] }
{ "id": "C0445623", "name": "microorganism", "pos": [ 159, 172 ] }
furthermore , our data indicate that 1 ) the morbidity of the combined procedures is relatively low , with no patients becoming incontinent and only 12.5 per cent becoming impotent , 2 ) 125iodine interstitial irradiation of the prostate after transurethral prostatectomy is safer in terms of postoperative complications...
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 71, 80 ] }
{ "id": "C0430022", "name": "diagnostic", "pos": [ 481, 491 ] }
in the control group of 80 patients with a variety of pulmonary diseases other than sarcoidosis ( pulmonary tuberculosis , pneumonia , pulmonary thromboembolism and primary lung cancer ) only 9 cases presented values higher than the normal + 2sd ( 11.2 % false positive ) .
nichd_parent_of
{ "id": "C0024115", "name": "pulmonary diseases", "pos": [ 54, 72 ] }
{ "id": "C0032285", "name": "pneumonia", "pos": [ 123, 132 ] }
liver enlargement or altered liver function tests were more frequent in the group of patients with a diagnostic liver biopsy , but they had no predictive value as it regards finding morphological changes of diagnostic interest .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 174, 181 ] }
{ "id": "C0011900", "name": "diagnostic", "pos": [ 207, 217 ] }
isolation and characterization of mycoplasma and acholeplasma from apparently healthy and diseased ( infectious sinusitis ) turkeys .
nichd_parent_of
{ "id": "C0009450", "name": "infectious", "pos": [ 101, 111 ] }
{ "id": "C0037199", "name": "sinusitis", "pos": [ 112, 121 ] }
infectious diseases , especially the worldwide epidemic diseases such as plague , smallpox , syphilis , tuberculosis have to a great extent selective effects .
nichd_parent_of
{ "id": "C0009450", "name": "infectious diseases", "pos": [ 0, 19 ] }
{ "id": "C0039128", "name": "syphilis", "pos": [ 93, 101 ] }
the determination of the sequence similarity of the ribosomal 16s rna of many bacteria and a few higher organisms has shown that the methanogenic , halophilic , and acido-thermophilic organisms are phylogenetically separated from the kingdoms of the eubacteria and eukaryotes thus representing a third kingdom called `` ...
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 104, 113 ] }
{ "id": "C0004611", "name": "eubacteria", "pos": [ 250, 260 ] }
a study of the behaviour of some sixty amino-acids and other ninhydrin-reacting substances on phenol- ; collidine ' filter-paper chromatograms , with notes as to the occurrence of some of them in biological fluids .
nichd_parent_of
{ "id": "C0439861", "name": "substances", "pos": [ 80, 90 ] }
{ "id": "C0005889", "name": "fluids", "pos": [ 207, 213 ] }
a study of the behaviour of some 60 amino-acids and other ninhydrin-reacting substances on phenol-collidine filter-paper chromatograms , with notes as to the occurrence of some of them in biological fluids .
nichd_parent_of
{ "id": "C0439861", "name": "substances", "pos": [ 77, 87 ] }
{ "id": "C0005889", "name": "fluids", "pos": [ 199, 205 ] }
[ comparative observations on the reaction to the old tuberculin test and to the bcg tuberculin test of infants infected in a natural way with tuberculosis and of infants given bcg inoculations ] .
nichd_parent_of
{ "id": "C0022885", "name": "test", "pos": [ 65, 69 ] }
{ "id": "C0041290", "name": "tuberculin test", "pos": [ 85, 100 ] }
use of anticoagulants in the treatment of heart disease with special reference to coronary thrombosis , rheumatic heart disease with thromboembolic complications and subacute bacterial endocarditis .
nichd_parent_of
{ "id": "C0018799", "name": "the", "pos": [ 25, 28 ] }
{ "id": "C0035439", "name": "rheumatic heart disease", "pos": [ 104, 127 ] }
relation of the size of the inoculum and the age of the infection to the curative dose of penicillin in experimental syphilis , with particular reference to the feasibility of its prophylactic use .
nichd_parent_of
{ "id": "C0009450", "name": "infection", "pos": [ 56, 65 ] }
{ "id": "C0039128", "name": "syphilis", "pos": [ 117, 125 ] }
quantitative studies of the in vitro virucidal activity of ether indicate that concentrations of this anesthetic within the range found in central nervous system tissues of anesthetized animals possess no virucidal activity .
nichd_parent_of
{ "id": "C0392762", "name": "quantitative", "pos": [ 0, 12 ] }
{ "id": "C1514721", "name": "range", "pos": [ 124, 129 ] }
despite the high concentrations of virus which developed in the intestinal tract following intravenous inoculation , it was not demonstrable in the stools , differing in this respect from theiler 's virus in mice and poliomyelitis virus in human beings and monkeys .
nichd_parent_of
{ "id": "C0042776", "name": "virus", "pos": [ 35, 40 ] }
{ "id": "C0206435", "name": "poliomyelitis virus", "pos": [ 217, 236 ] }
there was no evidence of multiplication in the nasal mucosa of mice which succumbed with encephalitis following nasal instillation of the virus , the course of events being comparable in this respect to the behavior of the m.v . poliomyelitis virus in rhesus monkeys .
nichd_parent_of
{ "id": "C0042776", "name": "virus", "pos": [ 138, 143 ] }
{ "id": "C0206435", "name": "poliomyelitis virus", "pos": [ 229, 248 ] }
the antibodies were obtainable after sensitization by acyl chlorides , acid anhydrides , and also substances of lesser reactivity , picryl chloride and 2:4 dinitrochlorobenzene , which are human allergens .
nichd_parent_of
{ "id": "C0439861", "name": "substances", "pos": [ 98, 108 ] }
{ "id": "C0002092", "name": "allergens", "pos": [ 195, 204 ] }
this paper presents our recent results of the mustard procedure ( intra-artrial baffle operation ) for the complete transposition of the great arteries performed in 24 infants and children during the past 6 years at the tohoku university hospital .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 54, 63 ] }
{ "id": "C0543467", "name": "operation", "pos": [ 87, 96 ] }
the intensity of the vegetative disorders was determined by intralobal localizations of the tumor , by the phase of the tumorous process and the histological structure of the neoplasm .
nichd_parent_of
{ "id": "C0012634", "name": "disorders", "pos": [ 32, 41 ] }
{ "id": "C0027651", "name": "tumor", "pos": [ 120, 125 ] }
this organism must be considered as a possible pathogen whenever a patient with an iud develops pelvic inflammatory disease .
nichd_parent_of
{ "id": "C0029235", "name": "organism", "pos": [ 5, 13 ] }
{ "id": "C0450254", "name": "pathogen", "pos": [ 47, 55 ] }
when demographic and psychologic data were assessed according to pain mechanisms , a pattern of patient groups emerged along a chronic pain continuum .
nichd_parent_of
{ "id": "C0030193", "name": "pain", "pos": [ 65, 69 ] }
{ "id": "C0150055", "name": "chronic pain", "pos": [ 127, 139 ] }
the concurrence of these diseases suggests that predisposition to immune-mediated disorders may be associated with the expression of multiple clinical entities .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 25, 33 ] }
{ "id": "C0021053", "name": "immune", "pos": [ 66, 72 ] }
1 secretion of catecholamines ( ca ) and dopamine-beta-hydroxylase ( dbh ) activity from the perfused rabbit and cat adrenal gland was studied following stimulation by a number of substances , including the physiological transmitter , acetylcholine ( ach ) , added to the perfusion fluid .
nichd_parent_of
{ "id": "C0439861", "name": "substances", "pos": [ 180, 190 ] }
{ "id": "C0005889", "name": "fluid", "pos": [ 282, 287 ] }
the role of genetic factors in the etiology of wilms ' tumor : two pairs of monozygous twins with congenital abnormalities ( aniridia ; hemihypertrophy ) and discordance for wilms ' tumor .
nichd_parent_of
{ "id": "C0000768", "name": "congenital abnormalities", "pos": [ 98, 122 ] }
{ "id": "C0332890", "name": "hemihypertrophy", "pos": [ 136, 151 ] }
immunoblastic lymphosarcoma ( ils ) is a newly recognized malignant lymphoreticular neoplasm and is included in the recent w.h.o . classification of lymphomas .
nichd_parent_of
{ "id": "C0006826", "name": "malignant", "pos": [ 58, 67 ] }
{ "id": "C0024299", "name": "lymphomas", "pos": [ 149, 158 ] }
a comparative study of a bcnu containing 4-drug program versus mopp versus 3-drug combinations in advanced hodgkin 's disease : a cooperative study by the cancer and leukemia group b .
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 155, 161 ] }
{ "id": "C0023418", "name": "group", "pos": [ 175, 180 ] }
the development of leukocyte adherence inhibition is traced from early experiments with murine tumors to recent applications in human cancer and in cell-mediated immunity in general .
nichd_parent_of
{ "id": "C0027651", "name": "tumors", "pos": [ 95, 101 ] }
{ "id": "C0006826", "name": "cancer", "pos": [ 134, 140 ] }
we developed anatomically related cross-sectional echocardiographic views to image the heart from the subxiphoid area in 100 children and infants with various forms of congenital heart disease studied prospectively before cardiac catheterization .
nichd_parent_of
{ "id": "C0008059", "name": "children", "pos": [ 125, 133 ] }
{ "id": "C0021270", "name": "infants", "pos": [ 138, 145 ] }
a comparison of the wide range achievement test and the peabody individual achievement test for educationally handicapped children .
nichd_parent_of
{ "id": "C0027361", "name": "individual", "pos": [ 64, 74 ] }
{ "id": "C0008059", "name": "children", "pos": [ 122, 130 ] }