text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these studies , together with an examination of the glycoconjugates released by sequential extraction with 0.5 % triton x-100 followed by 0.2 % sodium dodecyl sulphate , revealed that the glycoprotein of mol.wt . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
52,
67
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
188,
200
]
} |
adrenaline , 3-isobutyl-1-methylxanthine ( mix ) and dibutyryl cyclic amp ( bt2 cyclic amp ) stimulated type-l hormone-sensitive lipase ( hsl ) activity when measurements were made on defatted rat heart powders . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
53,
73
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
80,
90
]
} |
experiments were carried out to assess the effects of secretagogues on the polyphosphoinositides phosphatidylinositol 4-phosphate ( ptdins4p ) and phosphatidylinositol 4,5-bisphosphate [ ptdins ( 4,5 ) p2 ] on preparations of exocrine pancreas in vitro . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
75,
96
]
} | {
"id": "C0031621",
"name": "ptdins",
"pos": [
187,
193
]
} |
theophylline , 3-isobutyl-1-methylxanthine and adenosine deaminase decreased [ 32p ] pi incorporation , and adenosine and n6-phenylisopropyladenosine reversed these effects . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
0,
12
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
15,
42
]
} |
theophylline , 3-isobutyl-1-methylxanthine and adenosine deaminase decreased [ 32p ] pi incorporation , and adenosine and n6-phenylisopropyladenosine reversed these effects . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
47,
56
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
125,
149
]
} |
the stimulatory effect of n6-phenylisopropyladenosine on [ 32p ] pi incorporation into phospholipids in cells exposed to 3-isobutyl-1-methylxanthine was evident as soon as 3 min after addition of the adenosine analogue and maximum 10 min after its addition . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
29,
53
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
200,
209
]
} |
the study of the turnover of the milk proteins in cultured explants showed that virtually all of the casein synthesized remained intact in tissue explants cultured with 3 microm cortisol , whereas about 45 % of casein disappeared in 40h from explants cultured with 30nm-cortisol . | NA | {
"id": "C0026138",
"name": "milk proteins",
"pos": [
33,
46
]
} | {
"id": "C0007332",
"name": "casein",
"pos": [
211,
217
]
} |
therefore it appears that infection of balb/c 3t3 mouse fibroblasts with mycoplasma orale induces the mouse cells to produce and secrete collagenase . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
56,
67
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
108,
113
]
} |
immunological evidence is presented which confirms that pp95 , one of the major phosphoproteins accumulated in development of the cellular slime mould dictyostelium discoideum , is identical with spore coat protein sp13 . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
80,
95
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
207,
214
]
} |
the absolute rate of polyphosphoinositide breakdown in stimulated cells is similar to the rate previously reported for the disappearance of phosphatidylinositol [ kirk , michell & hems ( 1981 ) biochem . j . 194 , 155-165 ] . | NA | {
"id": "C0071655",
"name": "polyphosphoinositide",
"pos": [
21,
41
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
140,
160
]
} |
we therefore suggest that the initial response to hormones is breakdown of ptdins ( 4,5 ) p2 ( and ptdins4p ? ) , and that the simultaneous disappearance of phosphatidylinositol might be a result of its consumption for the continuing synthesis of polyphosphoinositides . | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
157,
177
]
} | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
247,
268
]
} |
this is the reverse order of the reactivity of the hydroperoxide with haemoglobin , which is greatest with methaemoglobin . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
70,
81
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
107,
121
]
} |
the method resolves three b-type cytochromes and four c-type cytochromes in membranes from aerobically and photosynthetically grown cells . | NA | {
"id": "C0010798",
"name": "cytochromes",
"pos": [
33,
44
]
} | {
"id": "C1256752",
"name": "c-type cytochromes",
"pos": [
54,
72
]
} |
at the same time , dibutyryl cyclic amp increased the incorporation of [ 14c ] glucosamine into dolichol-linked n-acetylglucosamine and nn'-diacetylchitobiose about 1.5-fold and into dolichol-linked oligosaccharides about 3-fold . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
79,
90
]
} | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
114,
131
]
} |
treatment of mice bearing l1210 leukaemia with 2-difluoromethylornithine , a specific inhibitor of ornithine decarboxylase ( ec 4.1.1.17 ) , produced a profound depletion of putrescine and spermidine in the tumour cells . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
174,
184
]
} | {
"id": "C0037871",
"name": "tumour cells",
"pos": [
207,
219
]
} |
involvement of intramitochondrial adenine nucleotides and inorganic phosphate in oxidative phosphorylation of extramitochondrially added adenosine-5'-diphosphate . | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
34,
53
]
} | {
"id": "C0001459",
"name": "adenosine-5",
"pos": [
137,
148
]
} |
from the studies it is concluded that ribosomal proteins l 5 , l 21/23 , l 32/33 , and l 36 are the main candidates for the ribosomal p site and proteins l 6 , l 18a , and l 28/29 for the ribosomal a site . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
38,
56
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
145,
153
]
} |
the interaction of ( +/- ) -bpde ( 1 ) with dna at neutral ph was investigated by the application of relaxed circular pbr322 dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
44,
47
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
109,
117
]
} |
both oyster glycogen and rabbit liver glycogen inhibited the activity of purified phosphorylase phosphatase catalytic subunit in a concentration-dependent manner . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
12,
20
]
} | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
32,
46
]
} |
the stimulation of 45ca2+ efflux by serum is also observed in quiescent cultures of rat-1 , swiss 3t6 and bhk cells and in secondary cultures of whole mouse embryo fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
110,
115
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
164,
175
]
} |
these results indicate that the protein produced by different tissues as well as the multiple isoforms are all derived from a common structural gene by processing . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
32,
39
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
94,
102
]
} |
the soluble guanylate cyclase activity of rat liver appears to be stimulated in vitro by insulin at pmolar concentrations , while proinsulin , denaturated insulin or desoctapeptide insulin , are not able to stimulate the studied enzymic activity . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
130,
140
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
181,
188
]
} |
supplementation of such cultures with vitamin a as either retinol or retinoic acid at concentrations of 10 ( -6 ) -10 ( -7 ) m was capable of significantly increasing collagen production . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
38,
47
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
69,
82
]
} |
methyltransferase i , which catalyzes methylation of phosphatidylethanolamine to phosphatidyl-n-mono-methylethanolamine was inhibited by gtp , whereas methyltransferase ii , which transfers methyl groups from s-adenosyl-l-methionine to produce phosphatidyl-n , n-dimethylethanolamine or phosphatidyl-choline was stimulated by gtp . | NA | {
"id": "C0025831",
"name": "methyltransferase",
"pos": [
0,
17
]
} | {
"id": "C0070781",
"name": "methyltransferase ii",
"pos": [
151,
171
]
} |
while hemin brings about a slight stimulation , allyl isopropyl acetamide ( a compound that destroys the heme bound to cytochrome p450 ) inhibits protein synthesis by a mechanism that appears to result exclusively from depletion of cytoplasmic heme . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
6,
11
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
244,
248
]
} |
to facilitate the study of the biochemistry of these modified nucleosides we have raised monoclonal antibodies to n6- ( delta 2-isopentenyl ) adenosine and n6- ( 4-hydroxy-3-methyl-but-2-enyl ) adenosine . | NA | {
"id": "C0022218",
"name": "isopentenyl ) adenosine",
"pos": [
128,
151
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
194,
203
]
} |
putrescine and spermidine sensitivity of lysine decarboxylase in escherichia coli : evidence for a constitutive enzyme and its mode of regulation . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
0,
10
]
} | {
"id": "C0037871",
"name": "sensitivity",
"pos": [
26,
37
]
} |
in terms of adenylate cyclase stimulation , three full agonists ( isoproterenol , epinephrine and norepinephrine ) , four partial agonists ( procaterol , salbutamol , fenoterol and zinterol ) , and four antagonists ( propranolol , metoprolol , atenolol and practolol ) were tested . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
82,
93
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
98,
112
]
} |
l-5-hydroxytryptophan ( 5htp ) ( with or without carbidopa pretreatment ) , l-tryptophan ( plus pargyline pretreatment ) , or tryptamine ( plus pargyline pretreatment ) all induced dose-dependent myoclonus in guinea pigs . | NA | {
"id": "C0000578",
"name": "5htp",
"pos": [
24,
28
]
} | {
"id": "C0041249",
"name": "l-tryptophan",
"pos": [
76,
88
]
} |
with [ me-14c ] choline as marker and after separation of choline and phosphocholine by ion-exchange column chromatography or thin layer chromatography on alumina , it is shown that 40 microm hemicholinium-3 ( hc-3 ) inhibits the cytosolic choline-kinase of rat liver and krebs cells . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
16,
23
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
70,
84
]
} |
the mononitrates were eliminated with a half-life of 30-70 min , giving rise to the completely denitrated product , adenosine-5'- ( n-ethyl-carboxamide ) ( neca ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
116,
125
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
156,
160
]
} |
2',3'-di-o-nitro-neca greater than isosorbide-2,5-dinitrate greater than 2'-nitro-neca greater than 3'-nitro-neca greater than isosorbide-2-mononitrate , while nitrate ester cleavage of isosorbide-5-mononitrate was not detectable . | NA | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
35,
45
]
} | {
"id": "C0064079",
"name": "isosorbide-5-mononitrate",
"pos": [
186,
210
]
} |
the proportion of pbmc with characteristics of nk cells was not decreased in the patients . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
18,
22
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} |
n- ( 2,6-dichloro-m-tolyl ) anthranilic acid , sodium salt ( meclofenamate sodium , meclomen ) , the sodium salt of meclofenamic acid , has anti-inflammatory activity both in animal models and in clinical use . | NA | {
"id": "C0025041",
"name": "meclofenamate sodium",
"pos": [
61,
81
]
} | {
"id": "C0025042",
"name": "meclofenamic acid",
"pos": [
116,
133
]
} |
resting levels of protein and cholesterol content of the hdl subfractions 1-3 increased ( subfraction 1 , density gradient 1.093 : 1.68 +/- 0.58 to 3.24 +/- 0.86 mmol/1 cholesterol , p less than 0.001 ) , while the concentrations in hdl subfractions 11-12 decreased proportionately ( subfraction 12 , density gradient 1.142 : 3.68 +/- 0.81 to 2.19 +/- 0.22 mmol/1 cholesterol , p less than 0.001 ) . | NA | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
30,
41
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
364,
375
]
} |
the effect of varying the compositions of dietary proteins on the relative cholesterolaemic effects of animal and vegetable proteins was investigated in rabbits . | NA | {
"id": "C0012177",
"name": "dietary proteins",
"pos": [
42,
58
]
} | {
"id": "C0042439",
"name": "vegetable proteins",
"pos": [
114,
132
]
} |
effects of fat level , feeding period , and source of fat on lipid fluidity and physical state of rabbit plasma lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
61,
66
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
112,
124
]
} |
ginsenosides ( saponins ) are considered to be the active agents for the suppression of cholesterogenesis and lipogenesis . | NA | {
"id": "C0061278",
"name": "ginsenosides",
"pos": [
0,
12
]
} | {
"id": "C0036189",
"name": "saponins",
"pos": [
15,
23
]
} |
the water soluble benzodiazepine midazolam was compared with diazepam , in doses of 0.07 mg kg-1 and 0.15 mg kg-1 respectively , administered i.v . to 100 patients undergoing gastroscopy . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
18,
32
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
33,
42
]
} |
dopaminergic control of gastric acid and gastrin secretion in man : lack of effects after acute oral administration of ibopamine , an analogue of dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
0,
12
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
146,
154
]
} |
the effect of oral administration of the dopaminergic drug , ibopamine , at the dose of 200 mg and 400 mg , on basal and submaximal pentagastrin ( 0.25 microgram kg-1 h-1 ) stimulated gastric acid secretion as well as basal serum gastrin concentration has been evaluated in 24 healthy individuals . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
132,
144
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
230,
237
]
} |
the effects of endralazine , administered intravenously , on blood pressure , heart rate , forearm blood flow , plasma renin activity , aldosterone , adrenaline and noradrenaline were studied in five patients with essential hypertension . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
150,
160
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
165,
178
]
} |
an association between malignant lymphoma ( both hodgkin 's disease ( hd ) and non-hodgkin lymphoma ) and exposure to organic solvents , phenoxy acids , or chlorophenols was previously reported . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
23,
41
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
49,
67
]
} |
an association between malignant lymphoma ( both hodgkin 's disease ( hd ) and non-hodgkin lymphoma ) and exposure to organic solvents , phenoxy acids , or chlorophenols was previously reported . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
23,
41
]
} | {
"id": "C0024305",
"name": "non-hodgkin lymphoma",
"pos": [
79,
99
]
} |
ethionine administered intraperitoneally to rats suffering from turpentine-induced inflammation preferentially reduced incorporation of 14c-leucine into fibrinogen , haptoglobin and other acute-phase proteins . | NA | {
"id": "C0016006",
"name": "fibrinogen",
"pos": [
153,
163
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
188,
208
]
} |
ethionine administered intraperitoneally to rats suffering from turpentine-induced inflammation preferentially reduced incorporation of 14c-leucine into fibrinogen , haptoglobin and other acute-phase proteins . | NA | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
166,
177
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
188,
208
]
} |
a simple non-invasive method is described in which the daily body weight change of the rat in response to weekly intragastric doses of ccl4 has been shown empirically to sufficiently reflect the state of the liver as to enable each dose of ccl4 to be calibrated by the weight change of the previous dose . | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
61,
72
]
} | {
"id": "C0005911",
"name": "weight change",
"pos": [
269,
282
]
} |
the standardization of birthweight for gestational age , taking into account sex of infant and maternal height and weight , is clinically useful and essential for some research purposes . | NA | {
"id": "C0005612",
"name": "birthweight",
"pos": [
23,
34
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
115,
121
]
} |
vasopressin effects on isolated non-pregnant myometrium and uterine arteries and their inhibition by deamino-ethyl-lysine-vasopressin and deamino-ethyl-oxytocin . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
0,
11
]
} | {
"id": "C0011701",
"name": "ethyl-lysine",
"pos": [
109,
121
]
} |
the contractile effects of lysine- ( l ) and arginine- ( a ) vasopressin ( vp ) on isolated non-pregnant myometrium and uterine arteries and the inhibition of these actions by two analogues of posterior pituitary hormones , deamino-ethyl-lvp ( de-lvp ) and deamino-ethyl-oxytocin ( de-oxy ) were investigated . | NA | {
"id": "C0032017",
"name": "posterior pituitary hormones",
"pos": [
193,
221
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
271,
279
]
} |
iron availability in potatoes and ferrous sulphate was measured in rats in a 10 d balance study and from a single meal using 59fe and 55fe as extrinsic labels . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
0,
4
]
} | {
"id": "C0060282",
"name": "ferrous sulphate",
"pos": [
34,
50
]
} |
digestion of dietary fibre and its components hemicellulose , cellulose and lignin were determined as well as colonic function . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
50,
59
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
76,
82
]
} |
mean digestibilities for the fibre from bread were : for ndf 0.34 , for hemicellulose 0.46 , for cellulose 0.20 and for lignin 0.04 . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
76,
85
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
120,
126
]
} |
the rotational relaxation of the enzyme-dna complexes is discussed in terms of alternative models involving rigid rod-sphere diffusion , conformational changes in the enzyme and/or dna , sliding motions of the protein along the dna , and torsional-bending motions of dna envisioned as a deformable rod . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
33,
39
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
167,
173
]
} |
a combination of gel chromatographic and density gradient fractionation of dmpc-apob incubation mixtures demonstrates that a reasonably well-defined complex of dmpc and apob is formed with a 4:1 w/w lipid : protein ratio . | NA | {
"id": "C0003601",
"name": "apob",
"pos": [
80,
84
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
207,
214
]
} |
the behavior of apob during its reassociation with phospholipid and the structural features of the dmpc-apob particle are similar to those observed in the interaction of solubilized membrane proteins with lipid rather than that of other apo-lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
58,
63
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
241,
253
]
} |
we sought a protein from yeast that would bind more strongly to single-stranded dna than to duplex dna and would stimulate the activity of the major yeast dna polymerase , but not polymerases from other organisms . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
64,
79
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
155,
158
]
} |
the hydrogen-deuterium ( h-d ) exchange kinetics of free and dna-bound ethidium dimer and acridine-ethidium heterodimer were measured by stopped flow using fluorescence detection . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
4,
12
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
13,
22
]
} |
in some cases , it was observed that the h-d exchange was much faster than the dissociation rate of dimer-dna complexes . | NA | {
"id": "C0020275",
"name": "h-d",
"pos": [
41,
44
]
} | {
"id": "C0011744",
"name": "h-d",
"pos": [
41,
44
]
} |
furthermore , the action of a catalyst ( imidazolium ion ) on the rate of h-d exchange showed that a dynamic structural fluctuation of the ligand in its dna complex was a necessary step on the exchange process . | NA | {
"id": "C0020275",
"name": "h-d",
"pos": [
74,
77
]
} | {
"id": "C0011744",
"name": "h-d",
"pos": [
74,
77
]
} |
following iron/ascorbate dependent peroxidation , the vesicles were labeled with a series of doxyl stearate spin probes which differed in the site of attachment of the nitroxide free radical to the fatty acid . | NA | {
"id": "C0037914",
"name": "labeled",
"pos": [
68,
75
]
} | {
"id": "C0016693",
"name": "free radical",
"pos": [
178,
190
]
} |
single-strand specific digestion with nuclease s1 of nuclear lysates from ultraviolet-irradiated cells , pulse labelled in the presence of hydroxyurea/arabinosylcytosine , caused a release of about 70 % of the prelabelled dna and 90 % of the pulse-labelled dna from the rapidly sedimenting material in sucrose gradients . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
10,
11
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
257,
260
]
} |
the percentage of rrna relative to the total rna , synthesized in the in vitro system with the nucleoid template , approaches the rate of the in vivo transcription . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
18,
22
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
45,
48
]
} |
aconitase ( citrate ( isocitrate ) hydro-lyase , ec 4.2.1.3 ) was isolated from saccharomyces cerevisiae , porcine and bovine heart by a simplified method including affinity chromatography on blue dextran-sepharose . | NA | {
"id": "C0001156",
"name": "aconitase",
"pos": [
0,
9
]
} | {
"id": "C0020239",
"name": "hydro-lyase",
"pos": [
35,
46
]
} |
the conformational change of the protein on guanidination was then examined by hydrogen-deuterium ( h-2h ) exchange reactions . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
79,
87
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
88,
97
]
} |
after fractionation , the rat duodenal-gland oligosaccharides could be characterized by application of 1h-nmr spectroscopy as being branched tetra- up to hexa-saccharide chains , all sharing the italicized trisaccharide element . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
45,
61
]
} | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
206,
219
]
} |
the rate constant for the inhibition of factor xa by antithrombin iii rose from 2.62 x 10 ( 4 ) m-1 x min-1 in the absence of divalent cations to a maximum of 6.40 x 10 ( 4 ) m-1 x min-1 at 5 mm ca2+ , 8.10 x 10 ( 4 ) m-1 x min-1 at 5 mm mn2+ , with a slight decrease in rate at higher cation concentrations . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
126,
142
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
286,
292
]
} |
the interactions of bovine milk lipoprotein lipase ( triacylglycero-protein acylhydrolase , ec 3.1.1.34 ) with the glycosaminoglycans heparin and heparan sulphate were investigated using the technique of fluorescence polarization spectroscopy . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
115,
133
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
134,
141
]
} |
the interactions of bovine milk lipoprotein lipase ( triacylglycero-protein acylhydrolase , ec 3.1.1.34 ) with the glycosaminoglycans heparin and heparan sulphate were investigated using the technique of fluorescence polarization spectroscopy . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
115,
133
]
} | {
"id": "C0019143",
"name": "heparan",
"pos": [
146,
153
]
} |
the sulphate-induced inhibition is apparently due to a rapid interaction of the anion with an active site of the enzyme which is followed by a slow ph-dependent ( pka = 7.2 ) transformation of the enzyme-inhibitor complex . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
4,
12
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
80,
85
]
} |
the subcellular distribution of five aminoacyl-trna synthetases from yeast , including lysyl- , arginyl- and methionyl-trna synthetases known to exist as high-molecular-weight complexes in lysates from higher eukaryotes , was investigated . | NA | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
37,
63
]
} | {
"id": "C0025653",
"name": "methionyl-trna synthetases",
"pos": [
109,
135
]
} |
comparison of binding and degradation of high density lipoprotein by intestinal mucosal cells , fibroblasts and adrenal cortical cells in culture . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
88,
93
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
96,
107
]
} |
in this study we have compared the binding and degradation of human high density lipoprotein ( hdl3 ) , devoid of apolipoprotein e , by rat intestinal ( mucosal ) and adrenal cells and by human fibroblasts in culture . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
175,
180
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
194,
205
]
} |
compositional analysis of the subclasses revealed an inverse relationship between cholesterol ester and cholesterol on a molar basis . | NA | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
82,
99
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
104,
115
]
} |
the incorporation of tritium into choline , phosphocholine and betaine by liver was similar for experimental and control animals , whereas there was a 3-fold increased incorporation into phosphatidylcholine of the cholesterol/cholate-fed rats . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
34,
41
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
44,
58
]
} |
binding specificity appeared unaffected since the relative abilities of triamcinolone acetonide , dexamethasone , cortisol , progesterone , and corticosterone to compete with labeled triamcinolone were similar at various pcmps concentrations which caused a progressive reduction of detectable cytosol binding . | NA | {
"id": "C0040866",
"name": "triamcinolone acetonide",
"pos": [
72,
95
]
} | {
"id": "C0040864",
"name": "triamcinolone",
"pos": [
183,
196
]
} |
human foreskin fibroblasts produce the protease plasminogen activator , as shown by the ability of cell extracts to lyse 125i-labelled fibrin in the presence of plasminogen . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
99,
103
]
} |
cellular plasminogen activator was stimulated up to 3-fold by 0.01-10 microm epinephrine , norepinephrine , or isoproterenol . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
77,
88
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
91,
105
]
} |
the action of two earlier isolated highly purified spleen thiol proteinases on angiotensins i and ii , bradykinin and kallidin was investigated . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
103,
113
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
118,
126
]
} |
novel drug reservoirs are described which , after their implantation under mouse skin , continuously released organic liquids such as the anti-epileptic drug valproic acid at preselected rates for periods up to several weeks . | NA | {
"id": "C3537002",
"name": "anti-epileptic drug",
"pos": [
138,
157
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
158,
171
]
} |
the predictive use of this correlation in assignment studies is illustrated for the calcium-binding protein paravalbumin , for which a crystal structure is available , and troponin c , for which no crystallographic data are available . | NA | {
"id": "C0006732",
"name": "calcium-binding protein",
"pos": [
84,
107
]
} | {
"id": "C0077400",
"name": "troponin c",
"pos": [
172,
182
]
} |
lymphocytes from patients with acute lymphocytic leukemia ( t-all ) showed an enzyme profile similar to that of normal thymocytes , i.e. , an elevated level of adenosine deaminase ( ada ) activity as compared with normal t lymphocytes , reduced activities of purine 5'nucleotidase ( 5'nt ) and purine nucleoside phosphorylase ( pnp ) , and a binomial distribution of the ldh isoenzyme pattern . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
78,
84
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
375,
384
]
} |
the effects of factor ix concentrate therapy on hemostasis in hemophilia patients were studied by means of the radiometric factor ixa assay , the coupled amidolytic assay for factor viia , and coagulant assays for factors ii , ix , and x , and antithrombin iii . | NA | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
123,
133
]
} | {
"id": "C0015491",
"name": "ix",
"pos": [
227,
229
]
} |
on one-dimensional analysis , bernard-soulier 's syndrome ( bss ) platelets also lacked the peripheral membrane glycoprotein , gpv ( mol wt 82,000 ) and a low molecular weight glycoprotein , gpix , ( nonreduced or reduced , mol wt congruent to 22,000 ) . | NA | {
"id": "C0025248",
"name": "membrane",
"pos": [
103,
111
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
176,
188
]
} |
these included antibodies to b1 and b2 , both expressed exclusively on b lymphocytes , but with the latter probably restricted to a narrow window of differentiation , bb-1 and lb-1 , both markers of activated lymphocytes , and 38.13 , a monoclonal antibody raised against and recognizing an epitope expressed on burkitt lymphoma cells . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
15,
25
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
237,
256
]
} |
there was no relationship between platelet-bound igg or albumin , and platelet size measured by either platelet protein or platelet volume , ( r less than 0.3 for all interactions ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
56,
63
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
112,
119
]
} |
a comparison of the pharmacokinetics of bacampicillin , ampicillin , amoxicillin , and cyclacillin : oral administration in infants and children . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
43,
53
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
69,
80
]
} |
of the 16 who underwent urinary diversion 11 were completely free of haemorrhage and three continued to have slight intermittent haematuria . | NA | {
"id": "C0019080",
"name": "haemorrhage",
"pos": [
69,
80
]
} | {
"id": "C0018965",
"name": "haematuria",
"pos": [
129,
139
]
} |
the prevalence of autoimmune diseases , including systemic lupus erythematosus , is increased in failure of certain host defence mechanisms . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
18,
37
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
50,
78
]
} |
serum folate concentrations during pregnancy in women with epilepsy : relation to antiepileptic drug concentrations , number of seizures , and fetal outcome . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
59,
67
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
128,
136
]
} |
reciprocal st depression in acute myocardial infarction may reflect ischaemia in territory distant from the site of infarction and is associated with a high risk of fatal arrhythmias and late morbidity . | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
68,
77
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
116,
126
]
} |
generally the total number of seizures suffered by each patient was small , the period of active epilepsy short , and remission when it occurred was usually permanent . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
30,
38
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
97,
105
]
} |
autoradiographic localization of 5'-n-ethylcarboxamido [ 3h ] adenosine ( [ 3h ] neca ) binding sites revealed a heterogeneous labeling of guinea-pig intestine with heavy labeling over the enteric ganglia and in clusters over the mucosa ; | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
62,
71
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
81,
85
]
} |
immunocytochemical localization of l-glutamate decarboxylase , gamma-aminobutyric acid transaminase , cysteine sulfinic acid decarboxylase , aspartate aminotransferase and somatostatin in rat retina . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
87,
99
]
} | {
"id": "C0004002",
"name": "aspartate",
"pos": [
141,
150
]
} |
correlating these analgesic shifts for a series of opioids with their affinity for different [ 3h ] opioid binding sites suggested an analgesic role for delta sites . | NA | {
"id": "C0002772",
"name": "analgesic",
"pos": [
18,
27
]
} | {
"id": "C0002771",
"name": "analgesic",
"pos": [
134,
143
]
} |
the pharmacological properties of the dopamine receptors are similar to those found for d1 receptors in adults except for the apparent affinities for agonists which were 5-10 times higher in fetal neurons . | NA | {
"id": "C0034798",
"name": "dopamine receptors",
"pos": [
38,
56
]
} | {
"id": "C0058697",
"name": "d1 receptors",
"pos": [
88,
100
]
} |
beta-adrenergic receptors of striatal and cerebellar fetal neurons are of the beta 1-subtype as indicated by their identical affinity for adrenaline and noradrenaline and by their homogeneous , high affinity for practolol ( ki = 1.3 x 10 ( -6 ) m ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
138,
148
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
153,
166
]
} |
pgf2 alpha , ooif , acetylcholine , adrenaline and noradrenaline induced tonic contractions , whereas pge2 , oxytocin and histamine induced relaxation . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
36,
46
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
51,
64
]
} |
the amounts of these elements in the excreta corresponded with the nitrogenous excretion products , carbohydrates and minerals . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
21,
29
]
} | {
"id": "C0028158",
"name": "nitrogenous",
"pos": [
67,
78
]
} |
a mixture of dnp 14c-labelled amino acids is added prior to hydrolysis and identification of the amino terminus is made on the basis of the 3h/14c ratios of the separated dnp-amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
30,
41
]
} | {
"id": "C0301714",
"name": "basis",
"pos": [
127,
132
]
} |
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