text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
it covers firstly the general problems of stroke , dementia and 'common symptoms ' of the elderly , and then looks in detail at those compounds which have to date attracted most attention ( ergot derivatives , cinnarizine , flunarizine , vincamine , eburnamonine , naftidrofuryl , oxpentifylline , piracetam and citicoline ) , as well as those which are currently considered investigational ( choline and lecithin ) . | NA | {
"id": "C0010725",
"name": "citicoline",
"pos": [
312,
322
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
393,
400
]
} |
finally , there is increasing awareness of the role of drugs in the development of neuromuscular disorders such as peripheral neuropathies , myasthenic syndromes and myopathies . | NA | {
"id": "C0027868",
"name": "neuromuscular disorders",
"pos": [
83,
106
]
} | {
"id": "C0031117",
"name": "peripheral",
"pos": [
115,
125
]
} |
the bacterial enzyme was inhibited by norethisterone ( ki = = 13.7 x 10 ( -6 ) mol ) and by norethisterone acetate ( ki = 12.1 x 10 ( -6 ) mol ) , whereas no inhibition by norethisterone was noted in the rat testis enzyme assay systems . | NA | {
"id": "C0068980",
"name": "norethisterone",
"pos": [
38,
52
]
} | {
"id": "C0028356",
"name": "norethisterone",
"pos": [
172,
186
]
} |
after coating round-bottomed wells of polyvinyl chloride with porcine monocomponent insulin , 50 microliters of serum from either insulin-treated diabetics or non diabetic controls was added to the wells , followed by the addition of 125i-protein a , and then the radioactivity of the bound 125i-protein a on the wells was counted . | NA | {
"id": "C0724601",
"name": "porcine",
"pos": [
62,
69
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
130,
137
]
} |
four groups of rats were given : cadmium chloride ( cd ) , cadmium chloride and mercuric chloride ( cd + hg ) , cadmium chloride and sodium selenite ( cd + se ) , or cadmium chloride , mercuric chloride , and sodium selenite ( cd + hg + se ) . | NA | {
"id": "C0025417",
"name": "mercuric chloride",
"pos": [
80,
97
]
} | {
"id": "C0008203",
"name": "cd",
"pos": [
227,
229
]
} |
the antibacterial activity of norfloxacin , an organic acid structurally related to nalidixic acid , was compared with that of the oral cephalosporins cefaclor and cephalexin , and with that of nalidixic acid , cinoxacin , amikacin , ampicillin , trimethoprim alone and the combination of trimethoprim and sulfamethoxazole . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
151,
159
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
164,
174
]
} |
the in vitro activity of norfloxacin ( mk366 ) against 477 aerobic gram-negative and gram-positive clinical isolates was compared to that of nalidixic acid , nitrofurantoin , ampicillin , cephalexin , trimethoprim , sulfamethoxazole , and the combination trimethoprim-sulfamethoxazole . | NA | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
216,
232
]
} | {
"id": "C0041044",
"name": "trimethoprim-sulfamethoxazole",
"pos": [
255,
284
]
} |
the o-specific polysaccharide of the 0114 antigen ( lipopolysaccharide ) of escherichia coli 0114 and oligosaccharides obtained from it by smith degradation and hydrogen fluoride solvolysis were analyzed , using proton and 13c nuclear magnetic resonance spectroscopy and methylation . | NA | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
4,
29
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
52,
70
]
} |
it is suggested that the alpha-1,3-galactosyltransferase functions in the biosynthesis of calf thymocyte cell-surface glycoconjugates including glycoproteins . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
118,
133
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
144,
157
]
} |
the results of binding assays indicated that three of the antibodies react with the same antigenic domain ( epitope 1 ) , but the fourth with a different one ( epitope 2 ) . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
89,
98
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
160,
167
]
} |
the contents of aspartic acid/asparagine + glutamic acid/glutamine , of basic amino acids , and of hydrophobic amino acids are 15 % , 12 % and 54 % respectively . | NA | {
"id": "C0061472",
"name": "acid",
"pos": [
25,
29
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
57,
66
]
} |
the contents of aspartic acid/asparagine + glutamic acid/glutamine , of basic amino acids , and of hydrophobic amino acids are 15 % , 12 % and 54 % respectively . | NA | {
"id": "C0003995",
"name": "asparagine",
"pos": [
30,
40
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
72,
89
]
} |
the contents of aspartic acid/asparagine + glutamic acid/glutamine , of basic amino acids , and of hydrophobic amino acids are 15 % , 12 % and 54 % respectively . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
57,
66
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
72,
89
]
} |
the contents of aspartic acid/asparagine + glutamic acid/glutamine , of basic amino acids , and of hydrophobic amino acids are 15 % , 12 % and 54 % respectively . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
72,
89
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
111,
122
]
} |
infusion of aldehyde such as acetaldehyde , propionaldehyde or benzaldehyde to perfused rat liver leads to an increase in hepatic ethane production . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
12,
20
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
29,
41
]
} |
radical scavenging by the addition of the flavonoid , cyanidanol , or by pretreatment with vitamin e ( alpha-tocopherol ) abolished ethane release , in agreement with lipid peroxidation as a source of alkane production during aldehyde metabolism . | NA | {
"id": "C0014969",
"name": "ethane",
"pos": [
132,
138
]
} | {
"id": "C0002065",
"name": "alkane",
"pos": [
201,
207
]
} |
initially synthesized proalbumin was converted with chase to serum-type albumin , while no pro-type precursor was identified for alpha 2u-globulin . | NA | {
"id": "C0032923",
"name": "proalbumin",
"pos": [
22,
32
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
61,
66
]
} |
the latter reaction which does not require added cations , can be inhibited by chlorpromazine , and this inhibition can be partially relieved by ca2+ ions . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
49,
56
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
150,
154
]
} |
gtp [ gamma s ] is a good analog of gtp regardless of the nature of the metal ion , suggesting that not all of the oxygens of the gamma-phosphate are involved in interactions to metal ion and protein . | NA | {
"id": "C0079469",
"name": "gtp [ gamma s",
"pos": [
0,
13
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
36,
39
]
} |
the following structure is novel for carbohydrate moieties in ovalbumin glycoasparagines : ( formula ; see text ) the present anion exchange chromatography in borate solution is well suited for separating and preparing oligosaccharides having similar molecular size but differing in content of vicinal cis-diol group . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
126,
131
]
} | {
"id": "C0006007",
"name": "borate",
"pos": [
159,
165
]
} |
a model for the quaternary structure of escherichia coli rna polymerase ( nucleosidetriphosphate : rna nucleotidyltransferase , ec 2.7.7.6 ) is presented . | NA | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
57,
71
]
} | {
"id": "C0035673",
"name": "rna nucleotidyltransferase",
"pos": [
99,
125
]
} |
a low molecular weight precursor of lipopolysaccharide was accumulated under conditions in which the membrane lipids of a fatty acid auxotroph of escherichia coli were reduced to a non-fluid state . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
36,
54
]
} | {
"id": "C0023767",
"name": "lipids",
"pos": [
110,
116
]
} |
the precursor could be chased into mature lipopolysaccharide by returning the membrane lipids to a normal fluid state . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
42,
60
]
} | {
"id": "C0023767",
"name": "lipids",
"pos": [
87,
93
]
} |
the processing of several outer membrane protein precursors , including the promatrix proteins , was also inhibited under these conditions . | NA | {
"id": "C0033665",
"name": "protein precursors",
"pos": [
41,
59
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
86,
94
]
} |
a high percentage of heparan sulfate was found in the urinary glycosaminoglycan pattern and a severe deficiency of n-acetylglucosamine-6-sulfate sulfatase was demonstrated in skin cultured fibroblasts from the patients . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
21,
36
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
62,
79
]
} |
investigation of cultured skin fibroblasts from these patients revealed normal pyruvate dehydrogenase and pyruvate carboxylase activities but the cells showed a decreased ability to oxidase pyruvate which was returned to normal on the addition of methylene blue . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
31,
42
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
146,
151
]
} |
in this minireview about transmitter coexistence situations in central nervous system and peripheral sympathetically innervated tissues , the classical transmitters , dopamine , noradrenaline , adrenaline and serotonin , together with peptides such as substance p , cholecystokinin and avian pancreatic polypeptide , have been considered . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
178,
191
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
194,
204
]
} |
although 7/32 patients developed adverse reactions there was no relationship between these and the plasma levels of either phenylbutazone or oxyphenbutazone . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
123,
137
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
141,
156
]
} |
the parent hybridoma , pc-140 , produces an antibody which binds phosphorylcholine and reacts with monoclonal antibodies that recognize myelomas of the t-15 idiotype . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
44,
52
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
99,
120
]
} |
specific suppressor t cells ( ts ) were induced in vitro by incubation of mouse spleen/lymph node cells with allogeneic heat-treated cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
22,
27
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
109,
119
]
} |
the absorption of mitogenic antibody was blocked in a similar fashion , thus demonstrating the close association of the determinant and the thy-1 antigen defined by monoclonal alloantibodies . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
28,
36
]
} | {
"id": "C0022144",
"name": "alloantibodies",
"pos": [
176,
190
]
} |
the c6 cell-derived factors enhance the response of thymocytes to phytohemagglutinin and the growth of fibroblasts whereas no effect on the growth of neuroblasts and of a strictly interleukin 2 ( il 2 ) -dependent t cell line was observed . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
7,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
103,
114
]
} |
one hour after systemic administration of dihydroxyphenylalanine- [ 3h ( g ) ] [ ( 3h ] dopa ) , a large number of silver grains appeared only in type 2 gc cells , thus indicating that type 2 cells are catecholamine-storing . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
88,
92
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
202,
215
]
} |
four benzomorphans ( n-allylnormetazocine , cyclazocine , phenazocine and pentazocine ) inhibited the binding of tritiated perhydrohistrionicotoxin and phencyclidine to ion channel sites with ic50 values between 0.4 and 5 microm . | NA | {
"id": "C0005075",
"name": "benzomorphans",
"pos": [
5,
18
]
} | {
"id": "C0031376",
"name": "phenazocine",
"pos": [
58,
69
]
} |
four benzomorphans ( n-allylnormetazocine , cyclazocine , phenazocine and pentazocine ) inhibited the binding of tritiated perhydrohistrionicotoxin and phencyclidine to ion channel sites with ic50 values between 0.4 and 5 microm . | NA | {
"id": "C0005075",
"name": "benzomorphans",
"pos": [
5,
18
]
} | {
"id": "C0030873",
"name": "pentazocine",
"pos": [
74,
85
]
} |
naloxone pretreatment ( 1.0 , 3.0 and 10.0 mg/kg i.v . ) failed to protect anesthetized pigs from cardiac arrhythmias including ventricular fibrillation ( vf ) and death following acute occlusion ( 20 min ) or reperfusion of the left anterior descending coronary artery . | NA | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
98,
117
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
128,
152
]
} |
the specific binding of both 125i-igf and 125i-insulin binding in the order of potency : insulin proinsulin igf . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
47,
54
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
97,
107
]
} |
igf , insulin and proinsulin competed for 125i-igf binding in the order of potency : igf proinsulin insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
18,
28
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
100,
107
]
} |
in addition , igf , insulin and proinsulin competed for 125i-insulin was about 450 times lower than that of insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
32,
42
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
108,
115
]
} |
( 3 ) membrane proteins ( 93 and 85 kilodalton ) were identified in k562a , whereas only the 93 kilodalton protein was detected in k562b and neither of the proteins were detected in k562c . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
6,
23
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
156,
164
]
} |
the enzyme activities and isozyme distribution of some glycolytic enzymes were studied in the k562 cell line before and after induction of hemoglobin formation . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
26,
33
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
66,
73
]
} |
colony-stimulating factor , interleukin 2 , interleukin 3 and the lectin , concanavalin a were also stimulatory but at concentrations from one hundred to one million times higher than that found for erythropoietin . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
0,
25
]
} | {
"id": "C0021757",
"name": "interleukin 3",
"pos": [
44,
57
]
} |
colony-stimulating factor , interleukin 2 , interleukin 3 and the lectin , concanavalin a were also stimulatory but at concentrations from one hundred to one million times higher than that found for erythropoietin . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
0,
25
]
} | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
199,
213
]
} |
ibotenate-induced seizures and lesions and their specific blockade by a selective antagonist may constitute valuable experimental paradigms for the investigation of seizure disorders . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
18,
26
]
} | {
"id": "C0014544",
"name": "seizure disorders",
"pos": [
165,
182
]
} |
in anesthetized rats , this state of granule cell hyperexcitability was occasionally accompanied by interictal epileptic spiking or brief electrographic seizures , but granule cell death was observed even in the absence of epileptic activity . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
111,
120
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
153,
161
]
} |
when animals were treated with the adenosine agonist , 2-chloroadenosine , prior to kindled amygdaloid stimulation , the elicited afterdischarge was shortened . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
35,
44
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
55,
72
]
} |
these observations suggested that ( i ) some ntfs may be present in normal nerves and others may be synthesized or accumulated in response to nerve injury , ( ii ) sensory , sympathetic , and spinal cord ntfs are separate agents and immunochemically distinct from nerve growth factor , ( iii ) ntfs predominantly originate from nerve stumps rather than from surrounding fluid , and ( iv ) proximal and distal nerve stumps accumulate and release ntfs at similar rates . | NA | {
"id": "C0027752",
"name": "nerve growth",
"pos": [
264,
276
]
} | {
"id": "C0027754",
"name": "ntfs",
"pos": [
445,
449
]
} |
the carotenoids beta-carotene ( c ) and canthaxanthine ( cx ) , with and without pro-vitamin a activity , respectively , when perorally administered to mice , markedly prevent benzo ( a ) pyrene photocarcinogenic enhancement ( bp-pce ) , continue to block such bp-pce and protect significantly against bp carcinogenesis in mice maintained in the dark . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
4,
15
]
} | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
16,
29
]
} |
the binding sites discriminate between the diastereoisomers l- and d-cis-diltiazem , reconize verapamil , gallopamil and tiapamil , and are sensitive to la3+-inhibition . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
94,
103
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
106,
116
]
} |
preferential enhancement of myoblast differentiation by insulin-like growth factors ( igf i and igf ii ) in primary cultures of chicken embryonic cells . | NA | {
"id": "C0037657",
"name": "insulin-like growth",
"pos": [
56,
75
]
} | {
"id": "C0021665",
"name": "igf i",
"pos": [
96,
101
]
} |
preferential enhancement of myoblast differentiation by insulin-like growth factors ( igf i and igf ii ) in primary cultures of chicken embryonic cells . | NA | {
"id": "C0037657",
"name": "insulin-like growth",
"pos": [
56,
75
]
} | {
"id": "C0021666",
"name": "igf ii",
"pos": [
96,
102
]
} |
after mild alkaline hydrolysis the tlc mobility of this ganglioside became identical to that of the usual hematoside . | NA | {
"id": "C0017082",
"name": "ganglioside",
"pos": [
56,
67
]
} | {
"id": "C0016897",
"name": "hematoside",
"pos": [
106,
116
]
} |
the bee venom neurotoxin apamin failed to affect 86rb outflow and insulin release from rat pancreatic islets stimulated by d-glucose or the ca2+-ionophore a23187 . | NA | {
"id": "C0004920",
"name": "bee venom",
"pos": [
4,
13
]
} | {
"id": "C0003521",
"name": "apamin",
"pos": [
25,
31
]
} |
these results suggest that the myelin proteolipid gene has been constructed from a small number of genetic elements , and that these elements are also found in non-myelin proteins . | NA | {
"id": "C0060617",
"name": "myelin proteolipid",
"pos": [
31,
49
]
} | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
164,
179
]
} |
the activation of the release process results in the concerted cosecretion of endogenous catecholamines , newly incorporated catecholamines , adenine nucleotides , chromogranins , dopamine beta-hydroxylase ( ec 1.14.17.1 ) , enkephalins and related opioid peptides , stored ascorbate and newly incorporated ascorbate , lysosomal hydrolases , and soluble acetylcholinesterase . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
225,
236
]
} | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
249,
264
]
} |
only little is known about the involvement of the epithelium of epidermoid cysts in dermatoses with keratinocytic changes because these cysts are excised only rarely . | NA | {
"id": "C0014511",
"name": "epidermoid cysts",
"pos": [
64,
80
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
136,
141
]
} |
a total of 60 patients with proven fungal infection of the skin took part in a single-blind comparative study of the efficacy , toleration and safety of tioconazole base 1 % w/w and miconazole nitrate 2 % creams applied twice daily for 14 days to patients with pityriasis versicolor and for 28 days to patients with dermatophyte and yeast infections . | NA | {
"id": "C0011630",
"name": "fungal infection of",
"pos": [
35,
54
]
} | {
"id": "C0040262",
"name": "pityriasis versicolor",
"pos": [
261,
282
]
} |
the initial uptake can be significantly reduced by an excess of diverse ecdysteroids with moulting hormone activity but not by hydrocortisone . | NA | {
"id": "C0058915",
"name": "ecdysteroids",
"pos": [
72,
84
]
} | {
"id": "C0013494",
"name": "moulting",
"pos": [
90,
98
]
} |
the authors report the case of a patient with hepatitis after the administration of dihydralazine , an analogue of hydralazine which is widely used in europe . | NA | {
"id": "C0012271",
"name": "dihydralazine",
"pos": [
84,
97
]
} | {
"id": "C0020223",
"name": "hydralazine",
"pos": [
115,
126
]
} |
endogenous insulin secretion and proinsulin levels were grossly elevated in the fasting state ( c-peptide 2.2-3.5 pmol/ml ; proinsulin approximately 1 pmol/ml ) . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
96,
105
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
124,
134
]
} |
the molar ratio of proinsulin to c-peptide , which is about 0.05 in fasting control subjects , was 0.23-0.45 , clearly showing that too high a proportion of proinsulin was being secreted . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
33,
42
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
157,
167
]
} |
this may indicate that the constant hyperstimulation of the b cell leads to reduced conversion of proinsulin to insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
98,
108
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
112,
119
]
} |
rather , it indicates that myogenic precursor cells are a heterogeneous population , within which individual cells are predetermined to undergo a set number of symmetrical mitoses prior to yielding terminally differentiated progeny . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
36,
51
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
109,
114
]
} |
in order to study the regulatory mechanisms of expression of different cds types , we made cell hybrids between teratocarcinoma otf9 cells ( t-cds ) and fibroblast l cells ( f-cds ) , and between otf9 cells ( t-cds ) and hepatoma mh cells ( no cds ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
153,
163
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
233,
238
]
} |
the secondary prevention of ischemic heart disease must , at the right time , recognize and efficaciously treat the categories of the illness ( myocardial infarction , angina pectoris , heart failure , arrhythmias , sudden death ) and restrain its development . | NA | {
"id": "C0151744",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0027051",
"name": "myocardial",
"pos": [
144,
154
]
} |
the concept that the prognostic significance of the arrhythmias is in a large part dependent upon the type and severity of the underlying cardiac disease is stressed . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
52,
63
]
} | {
"id": "C0018799",
"name": "of the",
"pos": [
120,
126
]
} |
the term torsade de pointe ( t.d.p . ) was first introduced by dessertenne ( 1966 ) to designate an unusual ventricular tachyarrhythmia characterized by paroxysms of v.t . at rates typically greater than 200 beats/m , in which the qrs morphology shows alternating polarity in a modulating pattern , so that the complexes appear to be twisting around the baseline . | NA | {
"id": "C0040479",
"name": "torsade de pointe",
"pos": [
9,
26
]
} | {
"id": "C0042514",
"name": "ventricular tachyarrhythmia",
"pos": [
108,
135
]
} |
the present findings appear to suggest that cystic formation in gastric mucosa may herald an early neoplastic growth at the luminal aspect in some of the cysts . | NA | {
"id": "C0027651",
"name": "neoplastic growth",
"pos": [
99,
116
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
154,
159
]
} |
since host defense may be abnormal in patients with inflammatory bowel disease , we assessed natural killer cell function in 34 patients with ulcerative colitis and crohn 's disease . | NA | {
"id": "C0021390",
"name": "inflammatory bowel",
"pos": [
52,
70
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
165,
181
]
} |
in a case of prenatal diagnosis of lymphangioma ( hygroma ) of the neck the results of sonographic and computer tomographic investigations were compared . | NA | {
"id": "C0024221",
"name": "lymphangioma",
"pos": [
35,
47
]
} | {
"id": "C0206620",
"name": "hygroma",
"pos": [
50,
57
]
} |
of the 5 beta-reduced metabolites , 17 alpha , 20 beta-dihydroxy-5 beta-pregnan-3-one was almost as effective as 17 alpha , 20 beta-diohprog in oocytes of amago salmon and rainbow trout , while the other 5 beta-reduced compounds ( 3 alpha-hydroxy-5 beta-pregnan-20-one , 17 alpha-hydroxy-5 beta-pregnane-3,20-dione , 3 alpha , 17 alpha-dihydroxy-5 beta-pregnan-20-one , 5 beta-pregnane-3 alpha , 17 alpha , 20 beta-triol , and 5 beta-pregnane-3 beta , 17 alpha , 20 beta-triol ) were almost or totally ineffective at the concentrations tested ( 1-0.001 micrograms/ml ) . | NA | {
"id": "C0033008",
"name": "3 alpha-hydroxy-5 beta-pregnan-20-one",
"pos": [
231,
268
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
434,
442
]
} |
yellow perch ovarian tissue converted [ 14c ] progesterone or [ 14c ] pregnenolone to six metabolites that were effective in inducing gvbd in the bioassays : 5 alpha-pregnanedione , 17 alpha-hydroxyprogesterone , 20 alpha-dihydroprogesterone , 17 alpha-hydroxy , 20 alpha-dihydroprogesterone ( tentatively identified ) , and two other unidentified metabolites . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
46,
58
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
272,
291
]
} |
effect of secretin , pancreozymin op-cck , and glucagon on bile flow and bile lipid secretion in rats . | NA | {
"id": "C0008328",
"name": "pancreozymin",
"pos": [
21,
33
]
} | {
"id": "C0037167",
"name": "op-cck",
"pos": [
34,
40
]
} |
in this study a perfusion technique has been used to investigate in vivo jejunal absorption and transmural potential difference evoked by the neutral amino acids phenylalanine ( 56 or 20 mmol/l ) and glycine ( 20 mmol/l ) , the dibasic amino acid lysine ( 56 or 5 mmol/l ) , and a dipeptide glycyl-l-phenylalanine ( 20 mmol/l ) in 11 children with pancreatic insufficiency due to cystic fibrosis and in three children with other causes of exocrine pancreatic insufficiency . | NA | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
142,
161
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
236,
246
]
} |
in this study a perfusion technique has been used to investigate in vivo jejunal absorption and transmural potential difference evoked by the neutral amino acids phenylalanine ( 56 or 20 mmol/l ) and glycine ( 20 mmol/l ) , the dibasic amino acid lysine ( 56 or 5 mmol/l ) , and a dipeptide glycyl-l-phenylalanine ( 20 mmol/l ) in 11 children with pancreatic insufficiency due to cystic fibrosis and in three children with other causes of exocrine pancreatic insufficiency . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
200,
207
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
236,
246
]
} |
these results indicate that the formation of circulating immune complexes may be a physiological response to a large load of dietary antigen but that in most adults a chronic increase of milk or soya consumption does not affect food antibody or immune complex concentrations . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
233,
241
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
245,
251
]
} |
in an immunohistochemical study of the presence of the beta subunit of human chorionic gonadotrophin ( hcg ) in ovarian neoplasms it was found that hcg was detectable in 42 % of ovarian epithelial tumors , an incidence of hcg synthesis which very closely approximates that found in radioimmunoassay studies . | NA | {
"id": "C0106132",
"name": "beta subunit",
"pos": [
55,
67
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
222,
225
]
} |
direct relationships between nodal metastasis and clinical stage , tumor grade , and histologic type of tumor were demonstrated . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
67,
72
]
} | {
"id": "C0027652",
"name": "histologic type of tumor",
"pos": [
85,
109
]
} |
neither the total nefa content nor the concentrations of individual fatty acids showed significant differences in the three phases of the menstrual cycle . | NA | {
"id": "C0015688",
"name": "nefa",
"pos": [
18,
22
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
68,
79
]
} |
with the exception of stearic acid we found almost constant relative concentration values for the individual fatty acids within the medium range of the long-chain nefa spectrum . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
109,
120
]
} | {
"id": "C0015688",
"name": "nefa",
"pos": [
163,
167
]
} |
the most frequent bleedings are menorrhagia and metrorrhagia in females and hemarthrosis in both sexes . | NA | {
"id": "C0019080",
"name": "bleedings",
"pos": [
18,
27
]
} | {
"id": "C0018924",
"name": "hemarthrosis",
"pos": [
76,
88
]
} |
their amino acid compositions differ chiefly in the contents of basic and acidic amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
6,
16
]
} | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
74,
92
]
} |
significant correlation between the calcium and phosphorus contents in the aorta indicates the presence of a probable calcium-phosphate complex . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
36,
43
]
} | {
"id": "C0006711",
"name": "calcium-phosphate",
"pos": [
118,
135
]
} |
but every symptomless person with raised bsr should be examined very carefully , especially for occult hepatic diseases ( active hepatitis , liver cirrhosis ) , for anaemias , leukaemias , malignant lymphomas and other malignant diseases . | NA | {
"id": "C0023895",
"name": "hepatic diseases",
"pos": [
103,
119
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
141,
156
]
} |
basal thyrotropin ( tsh ) levels in plasma significantly decreased after tryptophan or 5-hydroxytryptophan ( 5-htp ) administration , but not after pcpa administration . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
73,
83
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
109,
114
]
} |
plasma testosterone ( t ) , androstenedione ( a ) , follicle-stimulating hormone , ( fsh ) , luteinizing hormone ( lh ) , prolactin ( prl ) , and urinary 17-ketosteroids ( 17-cs ) have been measured in 152 women complaining of acne and/or hirsutism . | NA | {
"id": "C0002860",
"name": "androstenedione",
"pos": [
28,
43
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
154,
169
]
} |
the complete amino-acid sequence of the major hemoglobin component ( hba ) of the adult northern mallard ( anas platyrhynchos platyrhynchos ) is presented . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
46,
56
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
69,
72
]
} |
a goat antiserum raised against the preparation contains immunoglobulins g precipitating estradiol-receptor complexes , and antibodies releasing the steroid from its binding site . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
7,
16
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
124,
134
]
} |
the immunoglobulin g fraction of a goat antiserum raised against a presumed endoglycosidase-fission product of estradiol receptor from porcine uteri contains some antibodies which precipitate the estradiol/receptor complex and others which release the steroid from the protein . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
40,
49
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
163,
173
]
} |
this is the first ultrastructural study of a neoplasm arising in a parovarian mullerian ( paramesonephric ) cyst . | NA | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
45,
53
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
108,
112
]
} |
by using somatic cell hybrids between human fibroblasts and hamster or mouse cells , we have assigned the gene for human coproporphyrinogen oxidase to chromosome 9 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
44,
55
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
77,
82
]
} |
we report a patient with normal superoxide dismutase-1 ( sod-1 ) activity and an interstitial deletion of chromosome 21 resulting in monosomy for band q21 . | NA | {
"id": "C0008628",
"name": "deletion of chromosome",
"pos": [
94,
116
]
} | {
"id": "C0026499",
"name": "monosomy",
"pos": [
133,
141
]
} |
an investigation of fibroblast clones from two females heterozygous for the martin-bell syndrome showed that the fibroblasts of these individuals consist of two sub-populations , one with cells expressing the fra ( x ) ( q27 ) and another with cells in which this fragile site can not be induced . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
113,
124
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
244,
249
]
} |
the cincinnati lipid research clinic family study : commingling in the distributions of lipids and lipoprotein concentrations . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
88,
94
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
99,
110
]
} |
commingling in the distributions of five lipids and lipoproteins was investigated in a sample of 567 caucasians . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
41,
47
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
52,
64
]
} |
as the destruction of the allogeneic cells occurs in the lymphatic tissues , especially the spleen , it is paradoxical that there is sometimes an excess of the label associated with allogeneic cells in the spleen but evidence is presented that most of the isotope is no longer associated with living cells in that organ at 24 h after transfer . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
26,
42
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
300,
305
]
} |
synthetic analogues of the n-terminal lipid part of bacterial lipoprotein are b-lymphocyte mitogens in vitro and in vivo . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
38,
43
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
62,
73
]
} |
results of this study demonstrate that the covalent coupling of a protein antigen to the liposome surface is very effective in potentiating the protein-specific antibody response and the immunogenicity of the conjugate is dependent on the epitope density of the antigen . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
74,
81
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
239,
246
]
} |
the antigen , when treated with guanidine hydrochloride and 2-mercaptoethanol , lost its allergenic activity but retained an ability to induce igm or igg antibody . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
4,
11
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
89,
99
]
} |
b cells that have receptors for the fc portion of igg ( fcr gamma + b cell ) elaborate an immunoregulatory lymphokine termed suppressive b-cell factor ( sbf ) after binding immune complexes , such as sheep erythrocytes sensitized with igg anti-sheep erythrocyte antibody ( ea ) . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
173,
189
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
262,
270
]
} |
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