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<Instruct>: Given the context 'Mutational analysis of C3G assigns the SH3 binding region to a 50-amino acid region containing a proline-rich sequence.', select the correct biomedical concept corresponding to 'c3g'. Answer using one of the provided options.
<Options>: A: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1) B: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor) C: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1) D: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain) E: c1qg (homo sapiens) (aka complement c1q c chain) F: None of the above.
A
<Instruct>: Given the context 'The mRNAs of both the C3G and CRK proteins are expressed ubiquitously in human adult and fetal tissues.', select the correct biomedical concept corresponding to 'c3g'. Answer using one of the provided options.
<Options>: A: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor) B: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain) C: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1) D: c1qg (homo sapiens) (aka complement c1q c chain) E: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1) F: None of the above.
E
<Instruct>: Given the context 'The mRNAs of both the C3G and CRK proteins are expressed ubiquitously in human adult and fetal tissues.', select the correct biomedical concept corresponding to 'crk'. Answer using one of the provided options.
<Options>: A: crk7 (homo sapiens) (aka cyclin dependent kinase 12) B: crk (gallus gallus) (aka crk proto-oncogene, adaptor protein) C: v-crk avian sarcoma virus ct10 oncogene homolog (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 oncogene homolog) D: crk proto-oncogene, adaptor protein (homo sapiens) (aka crk proto-oncogene, adaptor protein) E: crkii (xenopus laevis) (v-crk avian sarcoma virus ct10 oncogene homolog s homeolog (xenopus laevis)) (aka v-crk avian sarcoma virus ct10 oncogene homolog s homeolog) F: None of the above.
D
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept corresponding to 'crk'. Answer using one of the provided options.
<Options>: A: v-crk avian sarcoma virus ct10 oncogene homolog (mus musculus) (aka v-crk avian sarcoma virus ct10 oncogene homolog) B: crkii (xenopus laevis) (v-crk avian sarcoma virus ct10 oncogene homolog s homeolog (xenopus laevis)) (aka v-crk avian sarcoma virus ct10 oncogene homolog s homeolog) C: crk7 (homo sapiens) (aka cyclin dependent kinase 12) D: crk (drosophila melanogaster) (crk oncogene (drosophila melanogaster)) (aka crk oncogene) E: crkii (homo sapiens) (aka crk proto-oncogene, adaptor protein) F: None of the above.
E
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept corresponding to 'c3g'. Answer using one of the provided options.
<Options>: A: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen) B: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain) C: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1) D: complement c3 (homo sapiens) (aka complement c3) E: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1) F: None of the above.
C
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept corresponding to 'c3g'. Answer using one of the provided options.
<Options>: A: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain) B: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1) C: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen) D: c1qg (homo sapiens) (aka complement c1q c chain) E: c3g (rattus norvegicus) (aka rap guanine nucleotide exchange factor 1) F: None of the above.
F
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept corresponding to 'grb2'. Answer using one of the provided options.
<Options>: A: grb2 related adaptor protein (homo sapiens) (aka grb2 related adaptor protein) B: growth factor receptor bound protein 2 (homo sapiens) (aka growth factor receptor bound protein 2) C: grb2 related adaptor protein 2 (homo sapiens) (aka grb2 related adaptor protein 2) D: grb2 associated binding protein 2 (homo sapiens) (aka grb2 associated binding protein 2) E: grb2 (bos taurus) (aka growth factor receptor bound protein 2) F: None of the above.
B
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept corresponding to 'ash'. Answer using one of the provided options.
<Options>: A: ash1 (absent, small, or homeotic)-like s homeolog (xenopus laevis) (aka ash1 (absent, small, or homeotic)-like s homeolog) B: ash (homo sapiens) (aka growth factor receptor bound protein 2) C: ash1-related 1 (arabidopsis thaliana) (aka set domain group 37) D: arabidopsis ash2 relative (arabidopsis thaliana) (aka trauco) E: ash1-related protein 1 (arabidopsis thaliana) (aka set domain group 26) F: None of the above.
B
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept corresponding to 'c3g'. Answer using one of the provided options.
<Options>: A: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen) B: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1) C: c3g (rattus norvegicus) (aka rap guanine nucleotide exchange factor 1) D: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor) E: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1) F: None of the above.
E
<Instruct>: Given the context 'A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. ', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c) B: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1) C: p55cdc (homo sapiens) (aka cell division cycle 20) D: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55) E: p55cdc (mus musculus) (aka cell division cycle 20) F: None of the above.
C
<Instruct>: Given the context 'A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. ', select the correct biomedical concept corresponding to 'cdc20'. Answer using one of the provided options.
<Options>: A: cdc20a (homo sapiens) (aka cell division cycle 20) B: cdc20 (xenopus laevis) (cell division cycle 20 s homeolog (xenopus laevis)) (aka cell division cycle 20 s homeolog) C: cdc20p (homo sapiens) (aka cell division cycle 20 pseudogene 1) D: cdc20[fizzy] (drosophila melanogaster) (aka fizzy) E: cdc20 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein cdc20) F: None of the above.
E
<Instruct>: Given the context 'A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. ', select the correct biomedical concept corresponding to 'cdc4'. Answer using one of the provided options.
<Options>: A: cdc4 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit cdc4) B: cdc4 (homo sapiens) (aka f-box and wd repeat domain containing 7) C: mcm4 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm4) D: cdc4 (drosophila melanogaster) (aka archipelago) E: cdc4 (candida albicans sc5314) (aka scf ubiquitin ligase complex subunit) F: None of the above.
A
<Instruct>: Given the context 'A novel protein, p55CDC, has been identified in cycling mammalian cells.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: p5cd (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1) B: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) C: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1) D: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55) E: p55cdc (homo sapiens) (aka cell division cycle 20) F: None of the above.
E
<Instruct>: Given the context 'The p55CDC protein appears to be essential for cell division, since transfection of antisense p55CDC cDNA into CHO cells resulted in isolation of only those cells which exhibited a compensatory increase in p55CDC transcripts in the sense orientation.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: p55cdc (homo sapiens) (aka cell division cycle 20) B: protein phosphatase 2a regulatory subunit cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55) C: p55cdc (mus musculus) (aka cell division cycle 20) D: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c) E: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) F: None of the above.
A
<Instruct>: Given the context 'The p55CDC protein appears to be essential for cell division, since transfection of antisense p55CDC cDNA into CHO cells resulted in isolation of only those cells which exhibited a compensatory increase in p55CDC transcripts in the sense orientation.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55) B: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) C: p55cdc (homo sapiens) (aka cell division cycle 20) D: p55cdc (xenopus tropicalis) (aka cell division cycle 20) E: p5cdh (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1) F: None of the above.
C
<Instruct>: Given the context 'The p55CDC protein appears to be essential for cell division, since transfection of antisense p55CDC cDNA into CHO cells resulted in isolation of only those cells which exhibited a compensatory increase in p55CDC transcripts in the sense orientation.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: p55cdc (xenopus tropicalis) (aka cell division cycle 20) B: p55cdc (mus musculus) (aka cell division cycle 20) C: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1) D: p55cdc (homo sapiens) (aka cell division cycle 20) E: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55) F: None of the above.
D
<Instruct>: Given the context 'The p55CDC protein appears to be essential for cell division, since transfection of antisense p55CDC cDNA into CHO cells resulted in isolation of only those cells which exhibited a compensatory increase in p55CDC transcripts in the sense orientation.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55) B: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c) C: p55cdc (mus musculus) (aka cell division cycle 20) D: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) E: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1) F: None of the above.
F
<Instruct>: Given the context 'Immunoprecipitation of p55CDC yielded protein complexes with kinase activity which fluctuated during the cell cycle.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: p55cdc (xenopus tropicalis) (aka cell division cycle 20) B: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c) C: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1) D: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) E: p55cdc (homo sapiens) (aka cell division cycle 20) F: None of the above.
E
<Instruct>: Given the context 'Since p55CDC does not have the conserved protein kinase domains, this activity must be due to one or more of the associated proteins in the immune complex.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: p55cdc (xenopus tropicalis) (aka cell division cycle 20) B: p55cdc (homo sapiens) (aka cell division cycle 20) C: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c) D: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55) E: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) F: None of the above.
B
<Instruct>: Given the context 'The highest levels of protein kinase activity were seen with alpha-casein and myelin basic protein as substrates and demonstrated a pattern of activity distinct from that described for the known cyclin-dependent cell division kinases.', select the correct biomedical concept corresponding to 'myelin basic protein'. Answer using one of the provided options.
<Options>: A: myelin basic protein (bos taurus) (aka myelin basic protein) B: myelin basic protein (homo sapiens) (aka myelin basic protein) C: myelin basic protein (xenopus tropicalis) (aka myelin basic protein) D: myelin-associated oligodendrocytic basic protein (mus musculus) (aka myelin-associated oligodendrocytic basic protein) E: mbp (mus musculus) (myelin basic protein (mus musculus)) (aka myelin basic protein) F: None of the above.
B
<Instruct>: Given the context 'The p55CDC protein was also phosphorylated in dividing cells.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: p55cdc (mus musculus) (aka cell division cycle 20) B: p55cdc (homo sapiens) (aka cell division cycle 20) C: protein phosphatase 2a regulatory subunit cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55) D: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) E: p5cd (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1) F: None of the above.
B
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a functional bipolar mitotic spindle in yeast cells.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: p55cdc (homo sapiens) (aka cell division cycle 20) B: p5cd (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1) C: p55cdc (mus musculus) (aka cell division cycle 20) D: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1) E: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) F: None of the above.
A
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a functional bipolar mitotic spindle in yeast cells.', select the correct biomedical concept corresponding to 'cdc20'. Answer using one of the provided options.
<Options>: A: cdc20c (homo sapiens) (aka fizzy and cell division cycle 20 related 1) B: cdc20 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein cdc20) C: cdc20 (xenopus laevis) (cell division cycle 20 s homeolog (xenopus laevis)) (aka cell division cycle 20 s homeolog) D: cdc20p (homo sapiens) (aka cell division cycle 20 pseudogene 1) E: cdc20/fizzy (drosophila melanogaster) (aka fizzy) F: None of the above.
B
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a functional bipolar mitotic spindle in yeast cells.', select the correct biomedical concept corresponding to 'cdc4'. Answer using one of the provided options.
<Options>: A: cdc4 (drosophila melanogaster) (aka archipelago) B: mcm dna helicase complex subunit mcm4 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm4) C: scf ubiquitin ligase complex subunit cdc4 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit cdc4) D: cdc24 (saccharomyces cerevisiae s288c) (aka rho family guanine nucleotide exchange factor cdc24) E: dna replication licensing factor mcm-4 (caenorhabditis elegans) (aka dna replication licensing factor mcm-4) F: None of the above.
C
<Instruct>: Given the context 'The G beta repeat has been postulated to mediate protein-protein interactions and, in p55CDC, may modulate its association with a unique cell cycle protein kinase.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1) B: p55cdc (xenopus tropicalis) (aka cell division cycle 20) C: p55cdc (homo sapiens) (aka cell division cycle 20) D: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55) E: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) F: None of the above.
C
<Instruct>: Given the context 'These findings suggest that p55CDC is a component of the mammalian cell cycle mechanism.', select the correct biomedical concept corresponding to 'p55cdc'. Answer using one of the provided options.
<Options>: A: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1) B: p55cdc (xenopus tropicalis) (aka cell division cycle 20) C: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1) D: p55cdc (homo sapiens) (aka cell division cycle 20) E: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c) F: None of the above.
D
<Instruct>: Given the context 'In the present study, serum from a patient with Sjögren's syndrome was used to identify a novel autoantigen which was designated Ge-1.', select the correct biomedical concept corresponding to 'ge-1'. Answer using one of the provided options.
<Options>: A: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3) B: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 s homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 s homeolog) C: gec1 (homo sapiens) (aka gaba type a receptor associated protein like 1) D: ge-1 (drosophila melanogaster) (aka ge-1) E: ge1 (homo sapiens) (aka enhancer of mrna decapping 4) F: None of the above.
E
<Instruct>: Given the context 'In the present study, serum from a patient with Sjögren's syndrome was used to identify a novel autoantigen which was designated Ge-1.', select the correct biomedical concept corresponding to 'ge-1'. Answer using one of the provided options.
<Options>: A: gec1 (homo sapiens) (aka gaba type a receptor associated protein like 1) B: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 l homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 l homeolog) C: ge-1 (xenopus tropicalis) (aka enhancer of mrna decapping 4) D: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3) E: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 s homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 s homeolog) F: None of the above.
F
<Instruct>: Given the context 'Using the patient's serum, a 4.8-kb cDNA encoding Ge-1 was identified.', select the correct biomedical concept corresponding to 'ge-1'. Answer using one of the provided options.
<Options>: A: gec1 (homo sapiens) (aka gaba type a receptor associated protein like 1) B: ge-1 (drosophila melanogaster) (aka ge-1) C: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 l homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 l homeolog) D: ge-1 (homo sapiens) (aka enhancer of mrna decapping 4) E: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 s homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 s homeolog) F: None of the above.
D
<Instruct>: Given the context 'Fusion proteins containing different portions of Ge-1 were used to identify a 58 amino acid immunoreactive region within the protein.', select the correct biomedical concept corresponding to 'ge-1'. Answer using one of the provided options.
<Options>: A: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 s homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 s homeolog) B: esg1 (xenopus tropicalis) (transducin like enhancer of split 1 (xenopus tropicalis)) (aka transducin like enhancer of split 1) C: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3) D: ge-1 (homo sapiens) (aka enhancer of mrna decapping 4) E: ge-1 (drosophila melanogaster) (aka ge-1) F: None of the above.
D
<Instruct>: Given the context 'The presence of the NLS motif within the immunoreactive region of Ge-1 and other nuclear autoantigens suggests that the NLS may be a target of human autoantibodies.', select the correct biomedical concept corresponding to 'ge-1'. Answer using one of the provided options.
<Options>: A: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 s homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 s homeolog) B: ge-1 (homo sapiens) (aka enhancer of mrna decapping 4) C: esg (xenopus tropicalis) (transducin like enhancer of split 1 (xenopus tropicalis)) (aka transducin like enhancer of split 1) D: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 l homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 l homeolog) E: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3) F: None of the above.
B
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept corresponding to 'aquaporin 1'. Answer using one of the provided options.
<Options>: A: aquaporin-1 (xenopus tropicalis) (aka aquaporin 1 (colton blood group)) B: aqpx1 (homo sapiens) (aka aquaporin 11) C: aqp0 (homo sapiens) (aka major intrinsic protein of lens fiber) D: aquaporin 1 (colton blood group) (homo sapiens) (aka aquaporin 1 (colton blood group)) E: aquaporin1 (xenopus laevis) (aquaporin 1 (colton blood group) l homeolog (xenopus laevis)) (aka aquaporin 1 (colton blood group) l homeolog) F: None of the above.
D
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept corresponding to 'aqp1'. Answer using one of the provided options.
<Options>: A: aqpx1 (homo sapiens) (aka aquaporin 11) B: aquaporin 1 (colton blood group) (homo sapiens) (aka aquaporin 1 (colton blood group)) C: aquaporin-1 (xenopus laevis) (aquaporin 1 (colton blood group) s homeolog (xenopus laevis)) (aka aquaporin 1 (colton blood group) s homeolog) D: aqp0 (homo sapiens) (aka major intrinsic protein of lens fiber) E: aqp-1 (homo sapiens) (aka mindy lysine 48 deubiquitinase 4) F: None of the above.
B
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept corresponding to 'chip'. Answer using one of the provided options.
<Options>: A: chi (drosophila melanogaster) (chip (drosophila melanogaster)) (aka chip) B: chip (arabidopsis thaliana) (aka carboxyl terminus of hsc70-interacting protein) C: chip (homo sapiens) (aka stip1 homology and u-box containing protein 1) D: e3 ubiquitin-protein ligase chip (caenorhabditis elegans) (aka e3 ubiquitin-protein ligase chip) E: pic (homo sapiens) (aka solute carrier family 25 member 3) F: None of the above.
F
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept corresponding to 'channel-forming integral membrane protein of 28 kda'. Answer using one of the provided options.
<Options>: A: c1orf28 (homo sapiens) (aka cell division cycle 73) B: cxorf28 (homo sapiens) (aka long intergenic non-protein coding rna 1546) C: c3orf28 (homo sapiens) (aka family with sequence similarity 162 member a) D: tmem28 (homo sapiens) (aka nalcn channel auxiliary factor 2) E: small integral membrane protein 28 (homo sapiens) (aka small integral membrane protein 28) F: None of the above.
F
<Instruct>: Given the context 'Its distinctive expression pattern implicates this fourth mammalian member of the aquaporin water channel family (designated gene symbol, AQP4) as the osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.', select the correct biomedical concept corresponding to 'aqp4'. Answer using one of the provided options.
<Options>: A: aqp4 (mus musculus) (aka aquaporin 4) B: aqp4 (bos taurus) (aka aquaporin 4) C: aqp4 (danio rerio) (aka aquaporin 4) D: aqp4 (homo sapiens) (aka aquaporin 4) E: aqp4.l (xenopus laevis) (aka aquaporin 4 l homeolog) F: None of the above.
D
<Instruct>: Given the context 'Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. ', select the correct biomedical concept corresponding to 'vasopressin'. Answer using one of the provided options.
<Options>: A: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin) B: vasopressin (sus scrofa) (aka vasopressin) C: vp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin) D: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog) E: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin) F: None of the above.
C
<Instruct>: Given the context 'Water excretion by the kidney is regulated by the peptide hormone vasopressin.', select the correct biomedical concept corresponding to 'vasopressin'. Answer using one of the provided options.
<Options>: A: avp (rattus norvegicus) (aka arginine vasopressin) B: vp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin) C: vasopressin (sus scrofa) (aka vasopressin) D: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog) E: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin) F: None of the above.
B
<Instruct>: Given the context 'Water excretion by the kidney is regulated by the peptide hormone vasopressin.', select the correct biomedical concept corresponding to 'vasopressin'. Answer using one of the provided options.
<Options>: A: vasopressin (sus scrofa) (aka vasopressin) B: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog) C: vasopressin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog) D: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin) E: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin) F: None of the above.
F
<Instruct>: Given the context 'Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood.', select the correct biomedical concept corresponding to 'vasopressin'. Answer using one of the provided options.
<Options>: A: avp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin) B: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin) C: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog) D: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin) E: vasopressin (sus scrofa) (aka vasopressin) F: None of the above.
A
<Instruct>: Given the context 'Recently, a molecular water channel (AQP-CD) has been cloned whose expression appears to be limited to the collecting duct.', select the correct biomedical concept corresponding to 'aqp-cd'. Answer using one of the provided options.
<Options>: A: aqpcd (xenopus tropicalis) (aka aquaporin 2) B: aqp-cd (homo sapiens) (aka aquaporin 2) C: aqp-cd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog) D: aqp-cd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog) E: aqp-cd (mus musculus) (aka aquaporin 2) F: None of the above.
B
<Instruct>: Given the context 'Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM.', select the correct biomedical concept corresponding to 'vasopressin'. Answer using one of the provided options.
<Options>: A: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin) B: vasopressin (sus scrofa) (aka vasopressin) C: arginine vasopressin (homo sapiens) (aka arginine vasopressin) D: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin) E: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog) F: None of the above.
C
<Instruct>: Given the context 'Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM.', select the correct biomedical concept corresponding to 'aqp-cd'. Answer using one of the provided options.
<Options>: A: aqp-cd (homo sapiens) (aka aquaporin 2) B: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog) C: aqpcd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog) D: aqpcd (xenopus tropicalis) (aka aquaporin 2) E: aqp-2 (oryctolagus cuniculus) (aka aquaporin 2) F: None of the above.
A
<Instruct>: Given the context 'Rat collecting ducts were perfused in vitro to determine water permeability and subcellular distribution of AQP-CD in the same tubules.', select the correct biomedical concept corresponding to 'aqp-cd'. Answer using one of the provided options.
<Options>: A: aqpcd (xenopus tropicalis) (aka aquaporin 2) B: aqp-cd (homo sapiens) (aka aquaporin 2) C: aqpcd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog) D: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2) E: aqp-cd (mus musculus) (aka aquaporin 2) F: None of the above.
B
<Instruct>: Given the context 'The collecting ducts were fixed for immunoelectron microscopy before, during, and after exposure to vasopressin.', select the correct biomedical concept corresponding to 'vasopressin'. Answer using one of the provided options.
<Options>: A: avp (rattus norvegicus) (aka arginine vasopressin) B: vasopressin (sus scrofa) (aka vasopressin) C: arginine vasopressin (homo sapiens) (aka arginine vasopressin) D: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog) E: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin) F: None of the above.
C
<Instruct>: Given the context 'Vasopressin exposure induced increases in water permeability and the absolute labeling density of AQP-CD in the APM.', select the correct biomedical concept corresponding to 'vasopressin'. Answer using one of the provided options.
<Options>: A: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog) B: vasopressin (sus scrofa) (aka vasopressin) C: avp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin) D: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin) E: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog) F: None of the above.
C
<Instruct>: Given the context 'Vasopressin exposure induced increases in water permeability and the absolute labeling density of AQP-CD in the APM.', select the correct biomedical concept corresponding to 'aqp-cd'. Answer using one of the provided options.
<Options>: A: aqpcd (xenopus tropicalis) (aka aquaporin 2) B: aqp-cd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog) C: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2) D: aqpcd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog) E: aqp-cd (homo sapiens) (aka aquaporin 2) F: None of the above.
E
<Instruct>: Given the context 'Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.', select the correct biomedical concept corresponding to 'vasopressin'. Answer using one of the provided options.
<Options>: A: arginine vasopressin (homo sapiens) (aka arginine vasopressin) B: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin) C: vasopressin (sus scrofa) (aka vasopressin) D: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog) E: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog) F: None of the above.
A
<Instruct>: Given the context 'Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.', select the correct biomedical concept corresponding to 'aqp-cd'. Answer using one of the provided options.
<Options>: A: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2) B: aqpcd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog) C: aqp-cd (homo sapiens) (aka aquaporin 2) D: aqp-cd (xenopus tropicalis) (aka aquaporin 2) E: aqp-cd (mus musculus) (aka aquaporin 2) F: None of the above.
C
<Instruct>: Given the context 'Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.', select the correct biomedical concept corresponding to 'aqp-cd'. Answer using one of the provided options.
<Options>: A: aqp-cd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog) B: aqp-2 (oryctolagus cuniculus) (aka aquaporin 2) C: aqp-cd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog) D: aqp-cd (mus musculus) (aka aquaporin 2) E: aqp-cd (xenopus tropicalis) (aka aquaporin 2) F: None of the above.
F
<Instruct>: Given the context 'We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.', select the correct biomedical concept corresponding to 'vasopressin'. Answer using one of the provided options.
<Options>: A: avp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin) B: avp (rattus norvegicus) (aka arginine vasopressin) C: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog) D: vasopressin (sus scrofa) (aka vasopressin) E: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog) F: None of the above.
A
<Instruct>: Given the context 'We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.', select the correct biomedical concept corresponding to 'aqp-cd'. Answer using one of the provided options.
<Options>: A: aqp-cd (homo sapiens) (aka aquaporin 2) B: aqp-cd (xenopus tropicalis) (aka aquaporin 2) C: aqp-cd (mus musculus) (aka aquaporin 2) D: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2) E: aqp-cd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog) F: None of the above.
A
<Instruct>: Given the context 'Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit. ', select the correct biomedical concept corresponding to 'eaa4'. Answer using one of the provided options.
<Options>: A: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2) B: episodic ataxia, type 8 (homo sapiens) (aka episodic ataxia, type 8) C: eaa5 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 3) D: ea6 (homo sapiens) (aka solute carrier family 1 member 3) E: glua4 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 4) F: None of the above.
A
<Instruct>: Given the context 'Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit. ', select the correct biomedical concept corresponding to 'glur6'. Answer using one of the provided options.
<Options>: A: grg6 (homo sapiens) (aka tle family member 6, subcortical maternal complex member) B: glr6 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2) C: glutamate receptor 2.6 (glycine max) (aka glutamate receptor 2.6) D: glur-6 (xenopus laevis) (aka glutamate receptor, ionotropic, kainate 2 s homeolog) E: glur6 (xenopus tropicalis) (aka glutamate receptor, ionotropic, kainate 2) F: None of the above.
B
<Instruct>: Given the context 'A cDNA encoding an ionotropic glutamate receptor subunit protein humEAA4 (GluR6), has been cloned from a human fetal brain library.', select the correct biomedical concept corresponding to 'humeaa4'. Answer using one of the provided options.
<Options>: A: eca4 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1) B: ela4 (homo sapiens) (aka chymotrypsin c) C: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2) D: enhancer of seven in absentia 4 (drosophila melanogaster) (aka enhancer of seven in absentia 4) E: saa4 (homo sapiens) (aka serum amyloid a4, constitutive) F: None of the above.
C
<Instruct>: Given the context 'A cDNA encoding an ionotropic glutamate receptor subunit protein humEAA4 (GluR6), has been cloned from a human fetal brain library.', select the correct biomedical concept corresponding to 'glur6'. Answer using one of the provided options.
<Options>: A: glr6 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2) B: mglu6 (homo sapiens) (aka glutamate metabotropic receptor 6) C: glur6 (rattus norvegicus) (aka glutamate ionotropic receptor kainate type subunit 2) D: grg6 (homo sapiens) (aka tle family member 6, subcortical maternal complex member) E: glutamate receptor 2.6 (glycine max) (aka glutamate receptor 2.6) F: None of the above.
A
<Instruct>: Given the context 'We have successfully established cell lines stably expressing humEAA4 in HEK-293 cells This is the first report of the establishment of stable cell lines expressing a glutamate receptor channel.', select the correct biomedical concept corresponding to 'humeaa4'. Answer using one of the provided options.
<Options>: A: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2) B: esa4 (homo sapiens) (aka esterase a4) C: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6) D: help4 (homo sapiens) (aka elongator acetyltransferase complex subunit 4) E: enhancer of seven in absentia 4 (drosophila melanogaster) (aka enhancer of seven in absentia 4) F: None of the above.
A
<Instruct>: Given the context 'The relative potency of compounds for displacing [3H]-kainate binding to humEAA4 receptors expressed in COS or HEK-293 cells is domoate > kainate > quisqualate > 6-cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate.', select the correct biomedical concept corresponding to 'humeaa4'. Answer using one of the provided options.
<Options>: A: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2) B: hae4 (homo sapiens) (aka plasminogen) C: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6) D: enhancer of seven in absentia 4 (drosophila melanogaster) (aka enhancer of seven in absentia 4) E: help4 (homo sapiens) (aka elongator acetyltransferase complex subunit 4) F: None of the above.
A
<Instruct>: Given the context 'Applications of kainate, glutamate, and domoate but not AMPA evoked rapidly desensitizing currents in cells expressing homo-oligomeric humEAA4 in a concentration dependent manner.', select the correct biomedical concept corresponding to 'humeaa4'. Answer using one of the provided options.
<Options>: A: hae4 (homo sapiens) (aka plasminogen) B: help4 (homo sapiens) (aka elongator acetyltransferase complex subunit 4) C: saa4 (homo sapiens) (aka serum amyloid a4, constitutive) D: hypertension, essential, susceptibility to, 4 (homo sapiens) (aka hypertension, essential, susceptibility to, 4) E: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2) F: None of the above.
E
<Instruct>: Given the context 'Although AMPA did not itself activate humEAA4 receptors it did reduce, to a limited extent, kainate-evoked responses.', select the correct biomedical concept corresponding to 'humeaa4'. Answer using one of the provided options.
<Options>: A: eca4 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1) B: ela4 (homo sapiens) (aka chymotrypsin c) C: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6) D: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2) E: esa4 (homo sapiens) (aka esterase a4) F: None of the above.
D
<Instruct>: Given the context 'Although AMPA did not itself activate humEAA4 receptors it did reduce, to a limited extent, kainate-evoked responses.', select the correct biomedical concept corresponding to 'humeaa4'. Answer using one of the provided options.
<Options>: A: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6) B: esa4 (homo sapiens) (aka esterase a4) C: eca4 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1) D: enhancer of seven in absentia 4 (drosophila melanogaster) (aka enhancer of seven in absentia 4) E: saa4 (homo sapiens) (aka serum amyloid a4, constitutive) F: None of the above.
F
<Instruct>: Given the context 'To date this effect has not been demonstrated with rat GluR6.', select the correct biomedical concept corresponding to 'glur6'. Answer using one of the provided options.
<Options>: A: grg6 (homo sapiens) (aka tle family member 6, subcortical maternal complex member) B: glur-6 (xenopus laevis) (aka glutamate receptor, ionotropic, kainate 2 s homeolog) C: glur8 (homo sapiens) (aka glutamate metabotropic receptor 8) D: glr6 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2) E: glur6 (xenopus tropicalis) (aka glutamate receptor, ionotropic, kainate 2) F: None of the above.
D
<Instruct>: Given the context 'Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. ', select the correct biomedical concept corresponding to 'src-like adapter'. Answer using one of the provided options.
<Options>: A: src like adaptor 2 (homo sapiens) (aka src like adaptor 2) B: src like adaptor (sus scrofa) (aka src like adaptor) C: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor) D: src like adaptor 2 (sus scrofa) (aka src like adaptor 2) E: src like adaptor (xenopus tropicalis) (aka src like adaptor) F: None of the above.
C
<Instruct>: Given the context 'Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. ', select the correct biomedical concept corresponding to 'eck'. Answer using one of the provided options.
<Options>: A: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3) B: cek7 (homo sapiens) (aka eph receptor a5) C: eck (homo sapiens) (aka eph receptor a2) D: etk (escherichia coli str. k-12 substr. mg1655) (aka protein-tyrosine kinase etk) E: ecfk (escherichia coli str. k-12 substr. mg1655) (aka outer membrane protein assembly factor bama) F: None of the above.
C
<Instruct>: Given the context 'Using a yeast two-hybrid screen to identify molecules that interact with the cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and stimulated phosphatidylinositol 3-kinase (Pandey, A., Lazar, D.F., Saltiel, A. R., and Dixit, V.M. (1994) J. Biol.', select the correct biomedical concept corresponding to 'eck'. Answer using one of the provided options.
<Options>: A: ecfk (escherichia coli str. k-12 substr. mg1655) (aka outer membrane protein assembly factor bama) B: eck (homo sapiens) (aka eph receptor a2) C: cek (homo sapiens) (aka fibroblast growth factor receptor 1) D: ehk-2 (homo sapiens) (aka eph receptor a6) E: eck (mus musculus) (aka eph receptor a2) F: None of the above.
B
<Instruct>: Given the context 'Using a yeast two-hybrid screen to identify molecules that interact with the cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and stimulated phosphatidylinositol 3-kinase (Pandey, A., Lazar, D.F., Saltiel, A. R., and Dixit, V.M. (1994) J. Biol.', select the correct biomedical concept corresponding to 'eck'. Answer using one of the provided options.
<Options>: A: etk (escherichia coli str. k-12 substr. mg1655) (aka protein-tyrosine kinase etk) B: ek (homo sapiens) (choline kinase beta (homo sapiens)) (aka choline kinase beta) C: cek7 (homo sapiens) (aka eph receptor a5) D: eck (mus musculus) (aka eph receptor a2) E: eck (homo sapiens) (aka eph receptor a2) F: None of the above.
E
<Instruct>: Given the context 'Hence, this protein was designated SLAP for Src-like adapter protein.', select the correct biomedical concept corresponding to 'slap'. Answer using one of the provided options.
<Options>: A: sla- (sus scrofa) (aka mhc class i antigen 1) B: slan (homo sapiens) (aka secis binding protein 2 like) C: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor) D: slap (homo sapiens) (sarcolemma associated protein (homo sapiens)) (aka sarcolemma associated protein) E: slap-2 (homo sapiens) (aka src like adaptor 2) F: None of the above.
C
<Instruct>: Given the context 'Hence, this protein was designated SLAP for Src-like adapter protein.', select the correct biomedical concept corresponding to 'src-like adapter'. Answer using one of the provided options.
<Options>: A: src like adaptor (homo sapiens) (aka src like adaptor) B: src like adaptor 2 (homo sapiens) (aka src like adaptor 2) C: src-like adaptor (mus musculus) (aka src-like adaptor) D: src like adaptor (sus scrofa) (aka src like adaptor) E: src like adaptor (xenopus tropicalis) (aka src like adaptor) F: None of the above.
A
<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept corresponding to 'slap'. Answer using one of the provided options.
<Options>: A: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor) B: slap-2 (homo sapiens) (aka src like adaptor 2) C: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase) D: sla- (sus scrofa) (aka mhc class i antigen 1) E: sla1p (homo sapiens) (aka src like adaptor) F: None of the above.
E
<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept corresponding to 'eck'. Answer using one of the provided options.
<Options>: A: ehk-2 (homo sapiens) (aka eph receptor a6) B: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3) C: cek (homo sapiens) (aka fibroblast growth factor receptor 1) D: ek (homo sapiens) (choline kinase beta (homo sapiens)) (aka choline kinase beta) E: eck (homo sapiens) (aka eph receptor a2) F: None of the above.
E
<Instruct>: Given the context 'Therefore, SLAP is a novel candidate downstream signaling intermediate and the first member of the Src family that resembles an adapter molecule.', select the correct biomedical concept corresponding to 'slap'. Answer using one of the provided options.
<Options>: A: slap (homo sapiens) (sarcolemma associated protein (homo sapiens)) (aka sarcolemma associated protein) B: sla- (sus scrofa) (aka mhc class i antigen 1) C: slap2 (homo sapiens) (aka src like adaptor 2) D: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor) E: sla1p (homo sapiens) (aka src like adaptor) F: None of the above.
E
<Instruct>: Given the context 'Therefore, SLAP is a novel candidate downstream signaling intermediate and the first member of the Src family that resembles an adapter molecule.', select the correct biomedical concept corresponding to 'slap'. Answer using one of the provided options.
<Options>: A: slap (homo sapiens) (sarcolemma associated protein (homo sapiens)) (aka sarcolemma associated protein) B: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor) C: slat (homo sapiens) (aka def6 guanine nucleotide exchange factor) D: sla- (sus scrofa) (aka mhc class i antigen 1) E: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase) F: None of the above.
F
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and spleen, respectively.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options.
<Options>: A: cb1a (homo sapiens) (aka cannabinoid receptor 1) B: cb1 (mus musculus) (aka cannabinoid receptor 1) C: cb1r (rattus norvegicus) (aka cannabinoid receptor 1) D: None of the above.
A
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and spleen, respectively.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene) C: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2) D: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2) E: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2) F: None of the above.
C
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options.
<Options>: A: cb1 (mus musculus) (aka cannabinoid receptor 1) B: cb1r (homo sapiens) (aka cannabinoid receptor 1) C: cb1 (rattus norvegicus) (aka cannabinoid receptor 1) D: None of the above.
B
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2) B: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2) C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2) D: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) E: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2) F: None of the above.
B
<Instruct>: Given the context 'CB1 was mainly expressed in the central nervous system and, to a lower extent, in several peripheral tissues such as adrenal gland, heart, lung, prostate, uterus, ovary, testis, bone marrow, thymus and tonsils.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options.
<Options>: A: cb1 (rattus norvegicus) (aka cannabinoid receptor 1) B: cb1 (mus musculus) (aka cannabinoid receptor 1) C: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1) D: None of the above.
C
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2) B: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2) D: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2) E: cb2 (homo sapiens) (aka cannabinoid receptor 2) F: None of the above.
E
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options.
<Options>: A: cb1r (mus musculus) (aka cannabinoid receptor 1) B: cb1r (rattus norvegicus) (aka cannabinoid receptor 1) C: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1) D: None of the above.
C
<Instruct>: Given the context 'Although CB2 mRNA was also detected in some other peripheral tissues, its level remained very low.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2) C: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2) D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2) E: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2) F: None of the above.
C
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2) B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2) C: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene) E: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2) F: None of the above.
A
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options.
<Options>: A: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1) B: cb1r (rattus norvegicus) (aka cannabinoid receptor 1) C: cb1r (mus musculus) (aka cannabinoid receptor 1) D: None of the above.
A
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options.
<Options>: A: cb1r (mus musculus) (aka cannabinoid receptor 1) B: cb1 (rattus norvegicus) (aka cannabinoid receptor 1) C: None of the above.
C
<Instruct>: Given the context 'Among the main human blood cell subpopulations, the distribution pattern of the CB2 mRNA displayed important variations.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2) B: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2) C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2) D: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2) E: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene) F: None of the above.
B
<Instruct>: Given the context 'The rank order of CB2 mRNA levels in these cells was B-cells > natural killer cells >> monocytes > polymorphonuclear neutrophil cells > T8 cells > T4 cells.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2) B: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2) C: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2) D: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) E: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2) F: None of the above.
A
<Instruct>: Given the context 'The prevailing expression of the CB2 gene in immune tissues was confirmed by Northern-blot analysis.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: cb2 (homo sapiens) (aka cannabinoid receptor 2) B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2) C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2) D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2) E: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2) F: None of the above.
A
<Instruct>: Given the context 'In addition, the expression of the CB2 protein was demonstrated by an immunohistological analysis performed on tonsil sections using specific anti-(human CB2) IgG; this experiment showed that CB2 expression was restricted to B-lymphocyte-enriched areas of the mantle of secondary lymphoid follicles.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene) B: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2) C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2) D: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) E: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2) F: None of the above.
B
<Instruct>: Given the context 'In addition, the expression of the CB2 protein was demonstrated by an immunohistological analysis performed on tonsil sections using specific anti-(human CB2) IgG; this experiment showed that CB2 expression was restricted to B-lymphocyte-enriched areas of the mantle of secondary lymphoid follicles.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2) B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene) C: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) D: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2) E: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2) F: None of the above.
D
<Instruct>: Given the context 'In addition, the expression of the CB2 protein was demonstrated by an immunohistological analysis performed on tonsil sections using specific anti-(human CB2) IgG; this experiment showed that CB2 expression was restricted to B-lymphocyte-enriched areas of the mantle of secondary lymphoid follicles.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene) B: cb2 (homo sapiens) (aka cannabinoid receptor 2) C: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) D: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2) E: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2) F: None of the above.
B
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options.
<Options>: A: cb1 (homo sapiens) (aka cannabinoid receptor 1) B: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1) C: cb1 (mus musculus) (aka cannabinoid receptor 1) D: None of the above.
A
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene) B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2) C: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) D: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2) E: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2) F: None of the above.
D
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options.
<Options>: A: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75) B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2) C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene) D: cb2 (homo sapiens) (aka cannabinoid receptor 2) E: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2) F: None of the above.
D
<Instruct>: Given the context 'Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. ', select the correct biomedical concept corresponding to 'proteinase-activated receptor 2'. Answer using one of the provided options.
<Options>: A: proteinase-activated receptor 2-like (gallus gallus) (aka proteinase-activated receptor 2-like) B: prokr2 (homo sapiens) (aka prokineticin receptor 2) C: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor) D: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1) E: par-1b (homo sapiens) (aka microtubule affinity regulating kinase 2) F: None of the above.
D
<Instruct>: Given the context 'Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. ', select the correct biomedical concept corresponding to 'proteinase-activated receptor 2'. Answer using one of the provided options.
<Options>: A: par3 (homo sapiens) (coagulation factor ii thrombin receptor like 2 (homo sapiens)) (aka coagulation factor ii thrombin receptor like 2) B: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor) C: f2r like thrombin or trypsin receptor 3 (homo sapiens) (aka f2r like thrombin or trypsin receptor 3) D: par-1b (homo sapiens) (aka microtubule affinity regulating kinase 2) E: proteinase-activated receptor 2-like (gallus gallus) (aka proteinase-activated receptor 2-like) F: None of the above.
F
<Instruct>: Given the context 'Since the physiological agonist was unknown, the receptor was named proteinase-activated receptor 2.', select the correct biomedical concept corresponding to 'proteinase-activated receptor 2'. Answer using one of the provided options.
<Options>: A: par3 (homo sapiens) (coagulation factor ii thrombin receptor like 2 (homo sapiens)) (aka coagulation factor ii thrombin receptor like 2) B: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1) C: prokr2 (homo sapiens) (aka prokineticin receptor 2) D: proteinase-activated receptor 2-like (gallus gallus) (aka proteinase-activated receptor 2-like) E: f2r like thrombin or trypsin receptor 3 (homo sapiens) (aka f2r like thrombin or trypsin receptor 3) F: None of the above.
B
<Instruct>: Given the context 'By fluorescence in situ hybridization, the human proteinase-activated receptor 2 gene was mapped to chromosomal region 5q13, where, previously, the related thrombin receptor gene has been located.', select the correct biomedical concept corresponding to 'proteinase-activated receptor 2'. Answer using one of the provided options.
<Options>: A: par3 (homo sapiens) (coagulation factor ii thrombin receptor like 2 (homo sapiens)) (aka coagulation factor ii thrombin receptor like 2) B: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor) C: par-1b (homo sapiens) (aka microtubule affinity regulating kinase 2) D: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1) E: prokr2 (homo sapiens) (aka prokineticin receptor 2) F: None of the above.
D
<Instruct>: Given the context 'We have described a protein (Hep27)', select the correct biomedical concept corresponding to 'hep27'. Answer using one of the provided options.
<Options>: A: hcp27 (homo sapiens) (aka cycs pseudogene 27) B: hh27 (homo sapiens) (aka nescient helix-loop-helix 2) C: ncc27 (homo sapiens) (aka chloride intracellular channel 1) D: es27 (homo sapiens) (aka ribosomal protein s27) E: hep27 (homo sapiens) (aka dehydrogenase/reductase 2) F: None of the above.
E
<Instruct>: Given the context 'The synthesis of Hep27 is inhibited in cells that, released from the butyrate block, have resumed DNA synthesis.', select the correct biomedical concept corresponding to 'hep27'. Answer using one of the provided options.
<Options>: A: hcp27 (homo sapiens) (aka cycs pseudogene 27) B: hh27 (homo sapiens) (aka nescient helix-loop-helix 2) C: gp27 (homo sapiens) (aka cd151 molecule (raph blood group)) D: hep27 (homo sapiens) (aka dehydrogenase/reductase 2) E: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta) F: None of the above.
D
<Instruct>: Given the context 'This report describes the cloning and the characterization of the cDNA coding for the Hep27 protein.', select the correct biomedical concept corresponding to 'hep27'. Answer using one of the provided options.
<Options>: A: hel-s-27 (homo sapiens) (aka serpin family b member 1) B: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta) C: hep27 (homo sapiens) (aka dehydrogenase/reductase 2) D: hh27 (homo sapiens) (aka nescient helix-loop-helix 2) E: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3) F: None of the above.
C
<Instruct>: Given the context 'The translation of the Hep27 cDNA predicts an amino acid sequence that can be aligned with those of the known short-chain alcohol dehydrogenase enzymes (SCAD) family.', select the correct biomedical concept corresponding to 'hep27'. Answer using one of the provided options.
<Options>: A: es27 (homo sapiens) (aka ribosomal protein s27) B: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3) C: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta) D: hcp27 (homo sapiens) (aka cycs pseudogene 27) E: hep27 (homo sapiens) (aka dehydrogenase/reductase 2) F: None of the above.
E