instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'This cancer-prone phenotype may correlate with the enhanced ability of several mxi1-deficient cell types, including prostatic epithelium, to proliferate.', select the correct biomedical concept corresponding to 'mxi1'. Answer using one of the provided options. | <Options>: A: max interactor 1, dimerization protein (mus musculus) (aka max interactor 1, dimerization protein)
B: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
C: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
D: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
E: mx1 (homo sapiens) (aka mx dynamin like gtpase 1)
F: None of the above. | A |
<Instruct>: Given the context 'Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner.', select the correct biomedical concept corresponding to 'mxi1'. Answer using one of the provided options. | <Options>: A: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
B: max interactor 1, dimerization protein (mus musculus) (aka max interactor 1, dimerization protein)
C: mx1 (homo sapiens) (aka mx dynamin like gtpase 1)
D: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
E: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner.', select the correct biomedical concept corresponding to 'myc'. Answer using one of the provided options. | <Options>: A: mycl proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
C: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
D: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
E: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
F: None of the above. | E |
<Instruct>: Given the context 'DNA sequence and muscle-specific expression of human sarcosin transcripts.
', select the correct biomedical concept corresponding to 'sarcosin'. Answer using one of the provided options. | <Options>: A: sarcosin (homo sapiens) (aka kelch like family member 41)
B: sarcosin (xenopus tropicalis) (aka kelch like family member 41)
C: sarcc (homo sapiens) (aka purinergic receptor p2y1)
D: sarcospan (mus musculus) (aka sarcospan)
E: sarcosin (rattus norvegicus) (aka kelch-like family member 41)
F: None of the above. | A |
<Instruct>: Given the context 'Consequently, we have termed this novel human sequence sarcosin.', select the correct biomedical concept corresponding to 'sarcosin'. Answer using one of the provided options. | <Options>: A: sarcospan (bos taurus) (aka sarcospan)
B: sarcosin (homo sapiens) (aka kelch like family member 41)
C: sarcosin (mus musculus) (aka kelch-like 41)
D: sarcosinemia autosomal recessive (mus musculus) (aka sarcosinemia autosomal recessive)
E: sarcosin (danio rerio) (aka kelch-like family member 41b)
F: None of the above. | B |
<Instruct>: Given the context 'Although novel, Southern hybridization analysis demonstrated that the sarcosin sequence has been conserved in several mammalian species.', select the correct biomedical concept corresponding to 'sarcosin'. Answer using one of the provided options. | <Options>: A: sarcospan (mus musculus) (aka sarcospan)
B: sarcospan (bos taurus) (aka sarcospan)
C: sarcosin (homo sapiens) (aka kelch like family member 41)
D: sarcosin (rattus norvegicus) (aka kelch-like family member 41)
E: sarcospan (homo sapiens) (aka sarcospan)
F: None of the above. | C |
<Instruct>: Given the context 'Although novel, Southern hybridization analysis demonstrated that the sarcosin sequence has been conserved in several mammalian species.', select the correct biomedical concept corresponding to 'sarcosin'. Answer using one of the provided options. | <Options>: A: sarcc (homo sapiens) (aka purinergic receptor p2y1)
B: sarcosin (xenopus tropicalis) (aka kelch like family member 41)
C: sarcosin (mus musculus) (aka kelch-like 41)
D: sarcospan (homo sapiens) (aka sarcospan)
E: sarcospan (mus musculus) (aka sarcospan)
F: None of the above. | F |
<Instruct>: Given the context 'Best macular dystrophy (BMD), also known as vitelliform macular dystrophy (VMD2; OMIM 153700), is an autosomal dominant form of macular degeneration characterized by an abnormal accumulation of lipofuscin within and beneath the retinal pigment epithelium cells.', select the correct biomedical concept corresponding to 'vmd2'. Answer using one of the provided options. | <Options>: A: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
B: mc4dn2 (homo sapiens) (aka synthesis of cytochrome c oxidase 2)
C: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
D: vmd2l3 (homo sapiens) (aka bestrophin 3)
E: vmd2 (homo sapiens) (aka bestrophin 1)
F: None of the above. | E |
<Instruct>: Given the context 'In pursuit of the disease gene, we limited the minimum genetic region by recombination breakpoint analysis and mapped to this region a novel retina-specific gene (VMD2).', select the correct biomedical concept corresponding to 'vmd2'. Answer using one of the provided options. | <Options>: A: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
B: vmd2 (homo sapiens) (aka bestrophin 1)
C: mc4dn2 (homo sapiens) (aka synthesis of cytochrome c oxidase 2)
D: vmd2l1 (homo sapiens) (aka bestrophin 2)
E: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
F: None of the above. | B |
<Instruct>: Given the context 'The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts.', select the correct biomedical concept corresponding to 'fth1'. Answer using one of the provided options. | <Options>: A: fthfd (homo sapiens) (aka aldehyde dehydrogenase 1 family member l1)
B: fthp1 (homo sapiens) (aka ferritin heavy chain 1 pseudogene 5)
C: fth (homo sapiens) (aka ferritin heavy chain 1)
D: ft1a (homo sapiens) (aka fucosyltransferase 6)
E: fer1 (drosophila melanogaster) (ferritin 1 heavy chain homologue (drosophila melanogaster)) (aka ferritin 1 heavy chain homologue)
F: None of the above. | C |
<Instruct>: Given the context 'The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts.', select the correct biomedical concept corresponding to 'vmd2'. Answer using one of the provided options. | <Options>: A: vmd2 (homo sapiens) (aka bestrophin 1)
B: vmd2l1 (homo sapiens) (aka bestrophin 2)
C: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
D: vmd2l2 (homo sapiens) (aka bestrophin 4)
E: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
F: None of the above. | A |
<Instruct>: Given the context 'The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts.', select the correct biomedical concept corresponding to 'fth1'. Answer using one of the provided options. | <Options>: A: fthl1 (homo sapiens) (aka ferritin heavy chain 1 pseudogene 1)
B: fth1 (homo sapiens) (aka ferritin heavy chain 1)
C: fthp1 (homo sapiens) (aka ferritin heavy chain 1 pseudogene 5)
D: ft1 (homo sapiens) (aka akt interacting protein)
E: ft1a (homo sapiens) (aka fucosyltransferase 6)
F: None of the above. | B |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
B: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
C: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
D: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
E: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
F: None of the above. | D |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', select the correct biomedical concept corresponding to 'rna helicase a'. Answer using one of the provided options. | <Options>: A: helicase (homo sapiens) (aka helicase for meiosis 1)
B: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
C: atp-dependent rna helicase a;rna helicase (caenorhabditis elegans) (aka atp-dependent rna helicase a;rna helicase)
D: mex-3 rna binding family member a (homo sapiens) (aka mex-3 rna binding family member a)
E: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
F: None of the above. | B |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', select the correct biomedical concept corresponding to 'breast cancer specific tumour suppressor protein'. Answer using one of the provided options. | <Options>: A: brca1p1 (homo sapiens) (aka brca1 pseudogene 1)
B: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
C: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
D: brcai (homo sapiens) (aka brca1 dna repair associated)
E: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
F: None of the above. | D |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: pseudo-brca1 (homo sapiens) (aka brca1 pseudogene 1)
B: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
C: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
D: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
E: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
F: None of the above. | D |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept corresponding to 'rna helicase a'. Answer using one of the provided options. | <Options>: A: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
B: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
C: swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog (caenorhabditis elegans) (aka swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog)
D: dead-box helicase 1 (homo sapiens) (aka dead-box helicase 1)
E: dexd-box helicase 39a (homo sapiens) (aka dexd-box helicase 39a)
F: None of the above. | B |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept corresponding to 'rna helicase a'. Answer using one of the provided options. | <Options>: A: dna helicase b (homo sapiens) (aka dna helicase b)
B: swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog (caenorhabditis elegans) (aka swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog)
C: dexd-box helicase 39a (homo sapiens) (aka dexd-box helicase 39a)
D: dead-box helicase 1 (homo sapiens) (aka dead-box helicase 1)
E: atp-dependent rna helicase a;rna helicase (caenorhabditis elegans) (aka atp-dependent rna helicase a;rna helicase)
F: None of the above. | F |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept corresponding to 'rha'. Answer using one of the provided options. | <Options>: A: rha (homo sapiens) (aka dexh-box helicase 9)
B: rhc (homo sapiens) (aka rh blood group ccee antigens)
C: rhag (homo sapiens) (aka rh associated glycoprotein)
D: rhd (homo sapiens) (aka rh blood group d antigen)
E: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
F: None of the above. | A |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
C: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
D: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
E: brca1 (homo sapiens) (aka brca1 dna repair associated)
F: None of the above. | E |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
C: brca1p1 (homo sapiens) (aka brca1 pseudogene 1)
D: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
E: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
F: None of the above. | B |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept corresponding to 'rha'. Answer using one of the provided options. | <Options>: A: rhd (homo sapiens) (aka rh blood group d antigen)
B: rhag (homo sapiens) (aka rh associated glycoprotein)
C: rha (homo sapiens) (aka dexh-box helicase 9)
D: rhr (homo sapiens) (aka adrenoceptor beta 1)
E: rhna (homo sapiens) (aka rh blood group ccee antigens)
F: None of the above. | C |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
B: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
C: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
D: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
E: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
F: None of the above. | A |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept corresponding to 'rha'. Answer using one of the provided options. | <Options>: A: rhd (homo sapiens) (aka rh blood group d antigen)
B: rhna (homo sapiens) (aka rh blood group ccee antigens)
C: rhs (homo sapiens) (aka tumor protein p63)
D: rha (homo sapiens) (aka dexh-box helicase 9)
E: rhr (homo sapiens) (aka adrenoceptor beta 1)
F: None of the above. | D |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
B: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
C: brca1 (homo sapiens) (aka brca1 dna repair associated)
D: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
E: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
F: None of the above. | C |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
C: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
D: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
E: brca1 (homo sapiens) (aka brca1 dna repair associated)
F: None of the above. | E |
<Instruct>: Given the context 'These data are the first to identify a specific protein interaction with the BRCA1 C-terminal domain and are consistent with the model that BRCA1 functions as a transcriptional coactivator.', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
C: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
D: pseudo-brca1 (homo sapiens) (aka brca1 pseudogene 1)
E: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
F: None of the above. | B |
<Instruct>: Given the context 'These data are the first to identify a specific protein interaction with the BRCA1 C-terminal domain and are consistent with the model that BRCA1 functions as a transcriptional coactivator.', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
B: pseudo-brca1 (homo sapiens) (aka brca1 pseudogene 1)
C: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
D: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
E: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
F: None of the above. | A |
<Instruct>: Given the context 'These data are the first to identify a specific protein interaction with the BRCA1 C-terminal domain and are consistent with the model that BRCA1 functions as a transcriptional coactivator.', select the correct biomedical concept corresponding to 'brca1'. Answer using one of the provided options. | <Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
C: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
D: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
E: brca1p1 (homo sapiens) (aka brca1 pseudogene 1)
F: None of the above. | F |
<Instruct>: Given the context 'Recently, a suitable candidate gene, CNGA3, encoding the alpha-subunit of the cone photoreceptor cGMP-gated cation channel, a key component of the phototransduction pathway, has been cloned and assigned to human chromosome 2q11 (refs 3,4).', select the correct biomedical concept corresponding to 'cnga3'. Answer using one of the provided options. | <Options>: A: cnga3 (mus musculus) (aka cyclic nucleotide gated channel alpha 3)
B: cnga3 (xenopus tropicalis) (aka cyclic nucleotide gated channel alpha 3)
C: cnga3 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 3)
D: cnga4 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 4)
E: cnga3.l (xenopus laevis) (aka cyclic nucleotide gated channel alpha 3 l homeolog)
F: None of the above. | C |
<Instruct>: Given the context 'We report the identification of missense mutations in CNGA3 in five families with RM.', select the correct biomedical concept corresponding to 'cnga3'. Answer using one of the provided options. | <Options>: A: cnga3.l (xenopus laevis) (aka cyclic nucleotide gated channel alpha 3 l homeolog)
B: cnga3.s (xenopus laevis) (aka cyclic nucleotide gated channel alpha 3 s homeolog)
C: cnga4 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 4)
D: cnga3 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 3)
E: cnga1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
F: None of the above. | D |
<Instruct>: Given the context 'The locus for the incomplete form of X-linked congenital stationary night blindness (CSNB2) maps to a 1.1-Mb region in Xp11.23 between markers DXS722 and DXS255.', select the correct biomedical concept corresponding to 'csnb2'. Answer using one of the provided options. | <Options>: A: csnk2b (homo sapiens) (aka casein kinase 2 beta)
B: csnb1b (homo sapiens) (aka glutamate metabotropic receptor 6)
C: csnbx2 (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
D: csnb2b (homo sapiens) (aka calcium binding protein 4)
E: csnb1 (homo sapiens) (aka nyctalopin)
F: None of the above. | C |
<Instruct>: Given the context 'We identified a retina-specific calcium channel alpha1-subunit gene (CACNA1F) in this region, consisting of 48 exons encoding 1966 amino acids and showing high homology to L-type calcium channel alpha1-subunits.', select the correct biomedical concept corresponding to 'cacna1f'. Answer using one of the provided options. | <Options>: A: cacna1f (xenopus tropicalis) (aka calcium channel, voltage-dependent, l type, alpha 1f subunit)
B: cacna1h (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 h)
C: cacna1f (rattus norvegicus) (aka calcium voltage-gated channel subunit alpha1 f)
D: cacna1f (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
E: cacna1f (sus scrofa) (aka calcium voltage-gated channel subunit alpha1 f)
F: None of the above. | D |
<Instruct>: Given the context 'Mutation analysis in 13 families with CSNB2 revealed nine different mutations in 10 families, including three nonsense and one frameshift mutation.', select the correct biomedical concept corresponding to 'csnb2'. Answer using one of the provided options. | <Options>: A: csn1s2b (homo sapiens) (aka casein alpha s2 like b, pseudogene)
B: csnb1c (homo sapiens) (aka transient receptor potential cation channel subfamily m member 1)
C: csnb1 (homo sapiens) (aka nyctalopin)
D: csnb1b (homo sapiens) (aka glutamate metabotropic receptor 6)
E: csnb2 (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
F: None of the above. | E |
<Instruct>: Given the context 'These data indicate that aberrations in a voltage-gated calcium channel, presumably causing a decrease in neurotransmitter release from photoreceptor presynaptic terminals, are a frequent cause of CSNB2.', select the correct biomedical concept corresponding to 'csnb2'. Answer using one of the provided options. | <Options>: A: csn2 (bos taurus) (aka casein beta)
B: csnb1b (homo sapiens) (aka glutamate metabotropic receptor 6)
C: csnbx2 (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
D: csnk2b (homo sapiens) (aka casein kinase 2 beta)
E: csnb1c (homo sapiens) (aka transient receptor potential cation channel subfamily m member 1)
F: None of the above. | C |
<Instruct>: Given the context 'ZW10 helps recruit dynactin and dynein to the kinetochore.
', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
B: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
C: zw-10 (drosophila melanogaster) (aka zeste-white 10)
D: zw10 (homo sapiens) (aka zw10 kinetochore protein)
E: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
F: None of the above. | D |
<Instruct>: Given the context 'Mutations in the Drosophila melanogaster zw10 gene, which encodes a conserved, essential kinetochore component, abolish the ability of dynein to localize to kinetochores.', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
B: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
C: l(1)zw10 (drosophila melanogaster) (aka zeste-white 10)
D: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
E: zw10 (homo sapiens) (aka zw10 kinetochore protein)
F: None of the above. | C |
<Instruct>: Given the context 'Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the kinetochore at metaphase, when their association with the spindle becomes apparent; (b) ZW10 and dynein both bind to functional neocentromeres of structurally acentric minichromosomes; and (c) the localization of both ZW10 and dynein to the kinetochore is abolished in cells mutant for the gene rough deal.', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
B: zw10 (drosophila melanogaster) (aka zeste-white 10)
C: zw10 (homo sapiens) (aka zw10 kinetochore protein)
D: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
E: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
F: None of the above. | C |
<Instruct>: Given the context 'Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the kinetochore at metaphase, when their association with the spindle becomes apparent; (b) ZW10 and dynein both bind to functional neocentromeres of structurally acentric minichromosomes; and (c) the localization of both ZW10 and dynein to the kinetochore is abolished in cells mutant for the gene rough deal.', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
B: zw-10 (drosophila melanogaster) (aka zeste-white 10)
C: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
D: zw10 (homo sapiens) (aka zw10 kinetochore protein)
E: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
F: None of the above. | D |
<Instruct>: Given the context 'Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the kinetochore at metaphase, when their association with the spindle becomes apparent; (b) ZW10 and dynein both bind to functional neocentromeres of structurally acentric minichromosomes; and (c) the localization of both ZW10 and dynein to the kinetochore is abolished in cells mutant for the gene rough deal.', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: l(1)zw10 (drosophila melanogaster) (aka zeste-white 10)
B: zw10 (danio rerio) (aka zw10 kinetochore protein)
C: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
D: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
E: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
F: None of the above. | F |
<Instruct>: Given the context 'Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the kinetochore at metaphase, when their association with the spindle becomes apparent; (b) ZW10 and dynein both bind to functional neocentromeres of structurally acentric minichromosomes; and (c) the localization of both ZW10 and dynein to the kinetochore is abolished in cells mutant for the gene rough deal.', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
B: zw10 (danio rerio) (aka zw10 kinetochore protein)
C: zw10 (homo sapiens) (aka zw10 kinetochore protein)
D: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
E: zw10 (drosophila melanogaster) (aka zeste-white 10)
F: None of the above. | C |
<Instruct>: Given the context 'Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the kinetochore at metaphase, when their association with the spindle becomes apparent; (b) ZW10 and dynein both bind to functional neocentromeres of structurally acentric minichromosomes; and (c) the localization of both ZW10 and dynein to the kinetochore is abolished in cells mutant for the gene rough deal.', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
B: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
C: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
D: zw10 (homo sapiens) (aka zw10 kinetochore protein)
E: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
F: None of the above. | D |
<Instruct>: Given the context 'ZW10's role in the recruitment of dynein to the kinetochore is likely to be reasonably direct, because dynamitin, the p50 subunit of the dynactin complex, interacts with ZW10 in a yeast two-hybrid screen.', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: zw10 (drosophila melanogaster) (aka zeste-white 10)
B: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
C: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
D: zw10 (homo sapiens) (aka zw10 kinetochore protein)
E: zw10 (danio rerio) (aka zw10 kinetochore protein)
F: None of the above. | D |
<Instruct>: Given the context 'ZW10's role in the recruitment of dynein to the kinetochore is likely to be reasonably direct, because dynamitin, the p50 subunit of the dynactin complex, interacts with ZW10 in a yeast two-hybrid screen.', select the correct biomedical concept corresponding to 'dynamitin'. Answer using one of the provided options. | <Options>: A: drn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
B: dynamitin (danio rerio) (aka dynactin 2 (p50))
C: dynamitin (xenopus tropicalis) (aka dynactin subunit 2)
D: dynamitin (homo sapiens) (aka dynactin subunit 2)
E: dynamitin (xenopus laevis) (dynactin subunit 2 l homeolog (xenopus laevis)) (aka dynactin subunit 2 l homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'ZW10's role in the recruitment of dynein to the kinetochore is likely to be reasonably direct, because dynamitin, the p50 subunit of the dynactin complex, interacts with ZW10 in a yeast two-hybrid screen.', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
B: zw10 (danio rerio) (aka zw10 kinetochore protein)
C: zw10 (homo sapiens) (aka zw10 kinetochore protein)
D: l(1)zw10 (drosophila melanogaster) (aka zeste-white 10)
E: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
F: None of the above. | C |
<Instruct>: Given the context 'Since in zw10 mutants no defects in chromosome behavior are observed before anaphase onset, our results suggest that dynein at the kinetochore is essential for neither microtubule capture nor congression to the metaphase plate.', select the correct biomedical concept corresponding to 'zw10'. Answer using one of the provided options. | <Options>: A: zw10 (homo sapiens) (aka zw10 kinetochore protein)
B: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
C: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
D: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
E: l(1)zw10 (drosophila melanogaster) (aka zeste-white 10)
F: None of the above. | A |
<Instruct>: Given the context 'The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
IFI 16 is an interferon-inducible nucleoprotein expressed by human monocytes.', select the correct biomedical concept corresponding to 'ifn-inducible nucleoprotein ifi 16'. Answer using one of the provided options. | <Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: ifi27 (homo sapiens) (aka interferon alpha inducible protein 27)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
E: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
F: None of the above. | D |
<Instruct>: Given the context 'The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
IFI 16 is an interferon-inducible nucleoprotein expressed by human monocytes.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
B: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
C: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
D: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
E: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
F: None of the above. | C |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
C: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
D: ifi16 (mus musculus) (aka interferon activated gene 204)
E: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
F: None of the above. | A |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept corresponding to 'p202'. Answer using one of the provided options. | <Options>: A: tppp/p20 (homo sapiens) (aka tubulin polymerization promoting protein family member 3)
B: p200 (homo sapiens) (at-rich interaction domain 2 (homo sapiens)) (aka at-rich interaction domain 2)
C: p18-20 (homo sapiens) (aka cd59 molecule (cd59 blood group))
D: p200 (homo sapiens) (arf guanine nucleotide exchange factor 1 (homo sapiens)) (aka arf guanine nucleotide exchange factor 1)
E: cg12032 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
F: None of the above. | F |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept corresponding to 'p202'. Answer using one of the provided options. | <Options>: A: p200 (homo sapiens) (at-rich interaction domain 2 (homo sapiens)) (aka at-rich interaction domain 2)
B: p28 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
C: p202 (homo sapiens) (aka tumor protein p53 binding protein 1)
D: tppp/p20 (homo sapiens) (aka tubulin polymerization promoting protein family member 3)
E: p200 (homo sapiens) (heat repeat containing 5b (homo sapiens)) (aka heat repeat containing 5b)
F: None of the above. | F |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: tumor protein p73 (homo sapiens) (aka tumor protein p73)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: p53cp (homo sapiens) (aka tumor protein p63)
D: tumor protein p53 (homo sapiens) (aka tumor protein p53)
E: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
F: None of the above. | D |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept corresponding to 'retinoblastoma gene product, prb'. Answer using one of the provided options. | <Options>: A: rbb (homo sapiens) (aka nacc family member 2)
B: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein)
C: prb1 (homo sapiens) (rb transcriptional corepressor like 1 (homo sapiens)) (aka rb transcriptional corepressor like 1)
D: rb-1 (homo sapiens) (aka rna binding motif protein 45)
E: prb (homo sapiens) (aka rb transcriptional corepressor 1)
F: None of the above. | E |
<Instruct>: Given the context 'In this study, we examined IFI 16 expression in myeloid precursor cells cultured in vitro in colony-forming assays using granulocyte (G-) and granulocyte-macrophage (GM-) colony-stimulating factor (CSF).', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
C: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
D: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
E: ifi16 (mus musculus) (aka interferon activated gene 204)
F: None of the above. | A |
<Instruct>: Given the context 'IFI 16 was expressed in 100% of CD34+ cells isolated from human bone marrow.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
C: ifi16 (mus musculus) (aka interferon activated gene 204)
D: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
E: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
F: None of the above. | B |
<Instruct>: Given the context 'IFI 16 was expressed in 100% of CD34+ cells isolated from human bone marrow.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd344 (homo sapiens) (aka frizzled class receptor 4)
B: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
C: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
D: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
E: fat4 (homo sapiens) (aka fat atypical cadherin 4)
F: None of the above. | C |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd34 molecule (gallus gallus) (aka cd34 molecule)
B: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
C: fat4 (homo sapiens) (aka fat atypical cadherin 4)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: cd34 molecule (homo sapiens) (aka cd34 molecule)
F: None of the above. | E |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept corresponding to 'cd14'. Answer using one of the provided options. | <Options>: A: cd14 (homo sapiens) (cd14 molecule (homo sapiens)) (aka cd14 molecule)
B: cd140a (homo sapiens) (aka platelet derived growth factor receptor alpha)
C: cd141 (homo sapiens) (aka thrombomodulin)
D: cd14 molecule (oryctolagus cuniculus) (aka cd14 molecule)
E: cd147 (homo sapiens) (aka basigin (ok blood group))
F: None of the above. | A |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
B: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
C: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
D: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
E: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
F: None of the above. | C |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept corresponding to 'cd14'. Answer using one of the provided options. | <Options>: A: cd14 molecule (homo sapiens) (aka cd14 molecule)
B: cd148 (homo sapiens) (aka protein tyrosine phosphatase receptor type j)
C: cd141 (homo sapiens) (aka thrombomodulin)
D: cd146 (homo sapiens) (aka melanoma cell adhesion molecule)
E: cd147 (homo sapiens) (aka basigin (ok blood group))
F: None of the above. | A |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
C: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
D: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
E: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
F: None of the above. | A |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
B: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
C: ifi16 (mus musculus) (aka interferon activated gene 204)
D: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
E: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
F: None of the above. | F |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept corresponding to 'cd14'. Answer using one of the provided options. | <Options>: A: cd142 (homo sapiens) (aka coagulation factor iii, tissue factor)
B: cd148 (homo sapiens) (aka protein tyrosine phosphatase receptor type j)
C: cd14 molecule (oryctolagus cuniculus) (aka cd14 molecule)
D: cd140a (homo sapiens) (aka platelet derived growth factor receptor alpha)
E: cd14 (homo sapiens) (cd14 molecule (homo sapiens)) (aka cd14 molecule)
F: None of the above. | E |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept corresponding to 'cd14'. Answer using one of the provided options. | <Options>: A: cd142 (homo sapiens) (aka coagulation factor iii, tissue factor)
B: cd140a (homo sapiens) (aka platelet derived growth factor receptor alpha)
C: cd14 (oryctolagus cuniculus) (aka cd14 molecule)
D: cd148 (homo sapiens) (aka protein tyrosine phosphatase receptor type j)
E: cd14 molecule (homo sapiens) (aka cd14 molecule)
F: None of the above. | E |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
B: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
C: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
D: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
E: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
F: None of the above. | B |
<Instruct>: Given the context 'Furthermore, in eight independent colony-forming assays, the number of IFI 16+ cells correlated closely with the numbers of monocyte precursors identified morphologically (R2 = 0.99), but was unrelated to the numbers of myelocytes, promyelocytes, and metamyelocytes; nor was IFI 16 expressed by erythroid or eosinophil precursors.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
C: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
D: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
E: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
F: None of the above. | E |
<Instruct>: Given the context 'Furthermore, in eight independent colony-forming assays, the number of IFI 16+ cells correlated closely with the numbers of monocyte precursors identified morphologically (R2 = 0.99), but was unrelated to the numbers of myelocytes, promyelocytes, and metamyelocytes; nor was IFI 16 expressed by erythroid or eosinophil precursors.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: ifi16 (mus musculus) (aka interferon activated gene 204)
B: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
C: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
D: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
E: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
F: None of the above. | C |
<Instruct>: Given the context 'We conclude that IFI 16 is expressed in CD34+ and monocytoid daughter cells, but is rapidly and markedly down-regulated at the corresponding stages of polymorphonuclear and erythroid development.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
B: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
C: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
D: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
E: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
F: None of the above. | E |
<Instruct>: Given the context 'We conclude that IFI 16 is expressed in CD34+ and monocytoid daughter cells, but is rapidly and markedly down-regulated at the corresponding stages of polymorphonuclear and erythroid development.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
B: cd34 molecule (homo sapiens) (aka cd34 molecule)
C: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
D: cd34 (gallus gallus) (aka cd34 molecule)
E: cd344 (homo sapiens) (aka frizzled class receptor 4)
F: None of the above. | B |
<Instruct>: Given the context 'This differential expression of IFI 16 in myeloid precursor subpopulations and its perceived molecular properties are consistent with a possible role in regulating myelopoiesis.', select the correct biomedical concept corresponding to 'ifi 16'. Answer using one of the provided options. | <Options>: A: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
B: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
E: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
F: None of the above. | E |
<Instruct>: Given the context 'A novel candidate oncogene, MCT-1, is involved in cell cycle progression.
', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
B: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
C: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
D: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
E: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
F: None of the above. | B |
<Instruct>: Given the context 'We termed this novel gene with multiple copies in a T-cell malignancy as MCT-1.', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
B: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
C: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
D: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
E: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
F: None of the above. | D |
<Instruct>: Given the context 'We termed this novel gene with multiple copies in a T-cell malignancy as MCT-1.', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
B: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
C: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
D: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
E: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
F: None of the above. | F |
<Instruct>: Given the context 'MCT-1 was localized to the long arm of chromosome Xq22-24 by flourescence in situ hybridization analysis.', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
B: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
C: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
D: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
E: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
F: None of the above. | A |
<Instruct>: Given the context 'Although there was no significant homology at the primary sequence level, there was a limited degree of amino acid homology with a domain of cyclin H that appears to specify protein-protein complexes.', select the correct biomedical concept corresponding to 'cyclin h'. Answer using one of the provided options. | <Options>: A: cyclin c (homo sapiens) (aka cyclin c)
B: cyclin p (homo sapiens) (aka cyclin p)
C: cyclin h (gallus gallus) (aka cyclin h)
D: ccng (homo sapiens) (aka cyclin g1)
E: p37 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
F: None of the above. | E |
<Instruct>: Given the context 'This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation.', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
B: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
C: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
D: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
E: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
F: None of the above. | E |
<Instruct>: Given the context 'This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation.', select the correct biomedical concept corresponding to 'cyclin h'. Answer using one of the provided options. | <Options>: A: p37 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
B: cyclin p (homo sapiens) (aka cyclin p)
C: ccng (homo sapiens) (aka cyclin g1)
D: ccnc (homo sapiens) (aka cyclin c)
E: cyclin h (gallus gallus) (aka cyclin h)
F: None of the above. | A |
<Instruct>: Given the context 'This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation.', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
B: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
C: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
D: mct (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
E: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
F: None of the above. | B |
<Instruct>: Given the context 'Overexpression of MCT-1 increased the proliferative rate of cells by decreasing the length of the G1 phase without a reciprocal increase in the S and G2-M phases.', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
B: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
C: mct1 (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
D: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
E: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
F: None of the above. | D |
<Instruct>: Given the context 'Therefore, we investigated the transforming ability of MCT-1 overexpression using soft agar growth assays and demonstrated that only MCT-1-overexpressing cells were able to establish colonies.', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
B: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
C: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
D: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
E: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
F: None of the above. | A |
<Instruct>: Given the context 'Therefore, we investigated the transforming ability of MCT-1 overexpression using soft agar growth assays and demonstrated that only MCT-1-overexpressing cells were able to establish colonies.', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
B: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
C: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
D: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
E: mct (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
F: None of the above. | A |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept corresponding to 'mct-1'. Answer using one of the provided options. | <Options>: A: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
B: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
C: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
D: solute carrier family 16 member 1 (homo sapiens) (aka solute carrier family 16 member 1)
E: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
F: None of the above. | A |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept corresponding to 'cyclin h'. Answer using one of the provided options. | <Options>: A: cyclin h (gallus gallus) (aka cyclin h)
B: cyclin p (homo sapiens) (aka cyclin p)
C: ccnc (homo sapiens) (aka cyclin c)
D: cyclin g1 (homo sapiens) (aka cyclin g1)
E: ccnh (homo sapiens) (aka cyclin h)
F: None of the above. | E |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept corresponding to 'cyclin h'. Answer using one of the provided options. | <Options>: A: cyclin p (homo sapiens) (aka cyclin p)
B: cyclin h (gallus gallus) (aka cyclin h)
C: ccng (homo sapiens) (aka cyclin g1)
D: cyclin c (homo sapiens) (aka cyclin c)
E: None of the above. | E |
<Instruct>: Given the context 'Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
', select the correct biomedical concept corresponding to '3alpha-hydroxysteroid dehydrogenase'. Answer using one of the provided options. | <Options>: A: steroid 5 alpha-reductase 3 (homo sapiens) (aka steroid 5 alpha-reductase 3)
B: 3alpha-hsd (xenopus tropicalis) (aka dehydrogenase/reductase (sdr family) member 9)
C: 7-dehydrocholesterol reductase (homo sapiens) (aka 7-dehydrocholesterol reductase)
D: 17-beta-hsd (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 1)
E: hsd3b1 (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1)
F: None of the above. | F |
<Instruct>: Given the context 'Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
', select the correct biomedical concept corresponding to 'akr1c3'. Answer using one of the provided options. | <Options>: A: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
B: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
C: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
D: akr1c1 (homo sapiens) (aka aldo-keto reductase family 1 member c1)
E: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
F: None of the above. | B |
<Instruct>: Given the context 'Human 3alpha-hydroxysteroid dehydrogenase exists in four isoforms, which belong to the aldo-keto reductase (AKR) superfamily and are named AKR1C1-AKR1C4.', select the correct biomedical concept corresponding to '3alpha-hydroxysteroid dehydrogenase'. Answer using one of the provided options. | <Options>: A: 3betahsd (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1)
B: 7-dehydrocholesterol reductase (homo sapiens) (aka 7-dehydrocholesterol reductase)
C: 3alpha-hsd (xenopus tropicalis) (aka dehydrogenase/reductase (sdr family) member 9)
D: 17-beta-hsd (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 1)
E: hydroxysteroid 17-beta dehydrogenase 3 (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 3)
F: None of the above. | F |
<Instruct>: Given the context 'The properties of AKR1C3 have not been fully characterized compared to the other isoforms.', select the correct biomedical concept corresponding to 'akr1c3'. Answer using one of the provided options. | <Options>: A: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
B: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
C: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
D: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
E: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
F: None of the above. | A |
<Instruct>: Given the context 'In addition, a cDNA that shows more than 99% homology with AKR1C3 cDNA has been cloned from human myeloblasts.', select the correct biomedical concept corresponding to 'akr1c3'. Answer using one of the provided options. | <Options>: A: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
B: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
C: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
D: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
E: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
F: None of the above. | B |
<Instruct>: Given the context 'The recombinant AKR1C3 prepared by site-directed mutagenesis of DBDH also showed the same properties as the wild-type DBDH.', select the correct biomedical concept corresponding to 'akr1c3'. Answer using one of the provided options. | <Options>: A: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
B: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
C: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
D: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
E: akr1c1 (homo sapiens) (aka aldo-keto reductase family 1 member c1)
F: None of the above. | D |
<Instruct>: Given the context 'Analyses of expression of mRNAs for DBDH and AKR1C3 by reverse transcription-PCR indicated that only one mRNA species for DBDH is expressed in 33 human specimens of liver, kidney, lung, brain, heart, spleen, adrenal gland, small intestine, placenta, prostate, and testis.', select the correct biomedical concept corresponding to 'akr1c3'. Answer using one of the provided options. | <Options>: A: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member a3)
B: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
C: akr1c1 (homo sapiens) (aka aldo-keto reductase family 1 member c1)
D: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
E: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
F: None of the above. | B |
<Instruct>: Given the context 'These results suggest that AKR1C3 acts as prostaglandin D2 11-ketoreductase, and that its principal gene in the human has a coding region represented by DBDH cDNA.', select the correct biomedical concept corresponding to 'akr1c3'. Answer using one of the provided options. | <Options>: A: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
B: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
C: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
D: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
E: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
F: None of the above. | D |
<Instruct>: Given the context 'In this study, we have identified a previously unclassified aldoketoreductase family member (termed HAKR e) that is expressed in HL60 cells.', select the correct biomedical concept corresponding to 'hakr e'. Answer using one of the provided options. | <Options>: A: hbrek (homo sapiens) (aka lemur tyrosine kinase 2)
B: ackr2 (homo sapiens) (aka atypical chemokine receptor 2)
C: hakrb (homo sapiens) (aka aldo-keto reductase family 1 member c3)
D: ackr6 (homo sapiens) (aka pitpnm family member 3)
E: hakrc (homo sapiens) (aka aldo-keto reductase family 1 member c1)
F: None of the above. | C |
<Instruct>: Given the context 'HAKR e is dramatically and transiently up-regulated in HL60 cells within 24 h of exposure to ATRA, further supporting the proposition that a member(s) of this family of enzymes play(s) a role in controlling cell growth and/or differentiation.', select the correct biomedical concept corresponding to 'hakr e'. Answer using one of the provided options. | <Options>: A: klkr (homo sapiens) (aka kallikrein 1)
B: ackr2 (homo sapiens) (aka atypical chemokine receptor 2)
C: hbrek (homo sapiens) (aka lemur tyrosine kinase 2)
D: hakrc (homo sapiens) (aka aldo-keto reductase family 1 member c1)
E: hakre (homo sapiens) (aka aldo-keto reductase family 1 member c3)
F: None of the above. | E |
<Instruct>: Given the context 'HAKR e is dramatically and transiently up-regulated in HL60 cells within 24 h of exposure to ATRA, further supporting the proposition that a member(s) of this family of enzymes play(s) a role in controlling cell growth and/or differentiation.', select the correct biomedical concept corresponding to 'hakr e'. Answer using one of the provided options. | <Options>: A: hakrd (homo sapiens) (aka aldo-keto reductase family 1 member c2)
B: hbrek (homo sapiens) (aka lemur tyrosine kinase 2)
C: hakrc (homo sapiens) (aka aldo-keto reductase family 1 member c1)
D: hakra (homo sapiens) (aka aldo-keto reductase family 1 member c4)
E: ackr2 (homo sapiens) (aka atypical chemokine receptor 2)
F: None of the above. | F |
<Instruct>: Given the context 'G protein-coupled receptors such as the receptors for bradykinin are present in low copy numbers in most natural cells.', select the correct biomedical concept corresponding to 'bradykinin'. Answer using one of the provided options. | <Options>: A: kininogen 1 (bos taurus) (aka kininogen 1)
B: bradykinin (xenopus tropicalis) (aka bradykinin receptor b2)
C: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
D: bk (homo sapiens) (aka kininogen 1)
E: kallikrein 1 (bos taurus) (aka kallikrein 1)
F: None of the above. | D |
<Instruct>: Given the context 'The B1 receptor failed to undergo ligand-induced phosphorylation.', select the correct biomedical concept corresponding to 'b1 receptor'. Answer using one of the provided options. | <Options>: A: b1r (homo sapiens) (aka bradykinin receptor b1)
B: adhesion g protein-coupled receptor b1 (homo sapiens) (aka adhesion g protein-coupled receptor b1)
C: bradykinin receptor b1 (bos taurus) (aka bradykinin receptor b1)
D: b1ar (homo sapiens) (aka adrenoceptor beta 1)
E: neuropeptides b and w receptor 1 (bos taurus) (aka neuropeptides b and w receptor 1)
F: None of the above. | A |
<Instruct>: Given the context 'However the B2 receptor showed selective phosphorylation of a minor 38 kDa band and lack of phosphorylation of a dominant 33 kDa band, indicating that only a fraction of the receptor protein is functionally linked to the kinase pathway.', select the correct biomedical concept corresponding to 'b2 receptor'. Answer using one of the provided options. | <Options>: A: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
B: bkb1r (homo sapiens) (aka bradykinin receptor b1)
C: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
D: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
E: adrb2 (homo sapiens) (aka adrenoceptor beta 2)
F: None of the above. | D |
<Instruct>: Given the context 'Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
', select the correct biomedical concept corresponding to 'hmre11b'. Answer using one of the provided options. | <Options>: A: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
B: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
C: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
D: olfactory receptor family 11 subfamily h member 4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
E: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
F: None of the above. | B |
<Instruct>: Given the context 'Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
', select the correct biomedical concept corresponding to 'mre11'. Answer using one of the provided options. | <Options>: A: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
B: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
C: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
D: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
E: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
F: None of the above. | F |
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