instruction stringlengths 205 1.17k | input stringlengths 91 1.88k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Size exclusion chromatography of protein that was diluted to 3 mg/mL. (J) Size exclusion chromatography of protein that was diluted to 3 mg/mL with dUMP and mTHF.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, ... | <Mentions>: [dump; mthf]
<Options>: A: 3-mthf (aka meciadanol)
B: 2-methyltetrahydrofuran
C: ddump (aka 2',3'-dideoxyuridine 5'-monophosphate)
D: uridine diphosphate
E: 2'-deoxyuridine 5'-phosphate (aka 2'-deoxyuridylic acid)
F: 5-methyltetrahydrofolate
G: 5,10-methylenetetrahydrofolic acid
H: 5-fluoro-2'-deoxyuridine-... | [E; G] |
<Instruct>: Given the context 'The Western blot and Coomassie brilliant blue of components separated by SEC.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [coomassie brilliant blue]
<Options>: A: blue, alcian (aka alcian blue)
B: swiss blue (aka methylene blue)
C: brilliant blue, disodium salt (aka brilliant blue)
D: coomassie blue r 250 (aka coomassie brilliant blue r)
E: coomassie blue g (aka coomassie brilliant blue)
F: None of the above. | [E] |
<Instruct>: Given the context 'The monomer was subjected to SDS-PAGE with 12% acrylamide, while the dimer and octamer were subjected to NATIVE-PAGE with 7.5% acrylamide.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, se... | <Mentions>: [sds; acrylamide]
<Options>: A: sodium sulfate
B: acetamides
C: methacrylamide
D: dextran sulfate sodium (aka dextran sulfate)
E: acrylamide
F: sodium dodecyltriethoxy sulfate (aka dodecyltriethoxy sulfate)
G: acetamide
H: dodecyl sulfate, sodium (aka sodium dodecyl sulfate)
I: dodecylsulfonic acid, sodium ... | [K; E] |
<Instruct>: Given the context 'The monomer was subjected to SDS-PAGE with 12% acrylamide, while the dimer and octamer were subjected to NATIVE-PAGE with 7.5% acrylamide.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, se... | <Mentions>: [sds; acrylamide]
<Options>: A: diacetone acrylamide (aka n-(1,1-dimethyl-3-oxobutyl)acrylamide)
B: acrylic resins
C: sodium dodecyl sulfate
D: acetamidine
E: acrylamide
F: sodium dodecyltriethoxy sulfate (aka dodecyltriethoxy sulfate)
G: sulfate, dextran (aka dextran sulfate)
H: amidines
I: dermatan sulfat... | [K; E] |
<Instruct>: Given the context 'The monomer was subjected to SDS-PAGE with 12% acrylamide, while the dimer and octamer were subjected to NATIVE-PAGE with 7.5% acrylamide.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, se... | <Mentions>: [sds; acrylamide]
<Options>: A: sodium dodecyl sulfate
B: acrylic resins
C: sodium sulfate
D: dermatan sulfate
E: acetamidine
F: diacetone acrylamide (aka n-(1,1-dimethyl-3-oxobutyl)acrylamide)
G: amidines
H: sodium dodecyltriethoxy sulfate (aka dodecyltriethoxy sulfate)
I: sulfate, dextran (aka dextran sul... | [J; J] |
<Instruct>: Given the context 'Determination of the oligomeric state of TYMS by mutated Cys.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cys]
<Options>: A: cysteinamine (aka cysteamine)
B: cysteic acid
C: homocysteine
D: l-cystine (aka cystine)
E: l cysteine (aka cysteine)
F: None of the above. | [E] |
<Instruct>: Given the context '(A) Available TYMS structures with Cys43, Cys180, and Cys210 sites depicted as red.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cys]
<Options>: A: cysteinamine (aka cysteamine)
B: creatine
C: choline
D: l-cysteine (aka cysteine)
E: thiols (aka sulfhydryl compounds)
F: None of the above. | [D] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [coomassie brilliant blue; cys; gly]
<Options>: A: l-cysteine (aka cysteine)
B: alcian blue
C: glycerol
D: thiols (aka sulfhydryl compounds)
E: brilliant blue g (aka coomassie brilliant blue)
F: cholesterol
G: glutamic acid
H: swiss blue (aka methylene blue)
I: guanine
J: glutamine
K: glycine
L: blue, bromo... | [E; A; K] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [coomassie brilliant blue; cys; gly]
<Options>: A: glucosamine
B: guanosine
C: cysteinylcysteine
D: l-serine (aka serine)
E: l-cysteine (aka cysteine)
F: cresyl blue (aka brilliant cresyl blue)
G: l-glutamate (aka glutamic acid)
H: coomassie blue r 250 (aka coomassie brilliant blue r)
I: glycine
J: blue, al... | [L; E; I] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [coomassie brilliant blue; cys; gly]
<Options>: A: guanine
B: guanosine
C: blue, bromophenol (aka bromphenol blue)
D: coomassie blue
E: cytosine
F: thiols (aka sulfhydryl compounds)
G: blue, alcian (aka alcian blue)
H: glycine
I: coomassie blue r 250 (aka coomassie brilliant blue r)
J: cholesterol
K: glucos... | [N; L; H] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [gly; cys; β-mercaptoethanol]
<Options>: A: choline
B: glycine
C: bismaleimidoethane (aka bis(maleimido)ethane)
D: cysteine
E: cytosine
F: glycyl glycine (aka glycylglycine)
G: glucosamine
H: thiols (aka sulfhydryl compounds)
I: 2-mercaptoethanol disulfide (aka 1,2-ethanedithiol)
J: glutamic acid
K: bromoet... | [B; D; O] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [gly; cys; β-mercaptoethanol]
<Options>: A: cholesterol
B: beta mercaptoethylamine (aka cysteamine)
C: ethane
D: cysteine
E: 2-mercaptoethanol disulfide (aka 1,2-ethanedithiol)
F: cysteinamine (aka cysteamine)
G: beta-erythroidine
H: cytosine
I: glycine
J: l-glutamine (aka glutamine)
K: mercaptoethanol
L: g... | [I; D; K] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [gly; cys; β-mercaptoethanol]
<Options>: A: beta tocopherol (aka beta-tocopherol)
B: homocysteine
C: choline
D: glycylglycine
E: 2-me (aka mercaptoethanol)
F: glyser (aka glycylserine)
G: 2-mercaptoethanol disulfide (aka 1,2-ethanedithiol)
H: bismaleimidoethane (aka bis(maleimido)ethane)
I: bromoethane
J: l... | [N; J; E] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [gly; cys; β-mercaptoethanol]
<Options>: A: bismaleimidoethane (aka bis(maleimido)ethane)
B: 2-me (aka mercaptoethanol)
C: glycylglycine
D: l serine (aka serine)
E: 2-mercaptoethanol disulfide (aka 1,2-ethanedithiol)
F: guanosine
G: choline
H: bromoethane
I: glucosamine
J: beta tocopherol (aka beta-tocopher... | [N; M; B] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [cys; gly]
<Options>: A: cysteinylcysteine
B: l cysteine (aka cysteine)
C: guanine
D: guanosine
E: l-serine (aka serine)
F: glycine
G: cystine
H: thiols (aka sulfhydryl compounds)
I: glycerol
J: l glutamic acid (aka glutamic acid)
K: None of the above. | [B; F] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [cys; gly]
<Options>: A: cytosine
B: cysteinamine (aka cysteamine)
C: glucosamine
D: l-cysteine (aka cysteine)
E: glyser (aka glycylserine)
F: glycerine (aka glycerol)
G: l serine (aka serine)
H: glycine
I: guanine
J: None of the above. | [D; H] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [cys; gly]
<Options>: A: l cysteine (aka cysteine)
B: glyser (aka glycylserine)
C: l-serine (aka serine)
D: guanine
E: homocysteine
F: glutathione
G: choline
H: cytosine
I: glycine
J: l-glutamine (aka glutamine)
K: None of the above. | [A; I] |
<Instruct>: Given the context 'The data were derived from PDB (Protein Data Bank) and the ID is 1YPV; (B,C) Western blot and Coomassie brilliant blue of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly (without β-mercaptoethanol); (D) size exclusion chromatography of TYMS with Cys43Gly, Cys180Gly, or Cys210Gly.', select the... | <Mentions>: [cys; gly]
<Options>: A: l-glutamine (aka glutamine)
B: cysteic acid
C: glycylglycine
D: l cysteine (aka cysteine)
E: glycerol
F: glycine
G: cholesterol
H: glutathione
I: cysteinylcysteine
J: None of the above. | [D; F] |
<Instruct>: Given the context '(A) Reaction process curves of dUMP for TYMS monomer, the left panel showing the substrate saturation curve, and the right panel showing the Lineweaver–Burk double-reciprocal plot; (B) reaction process curves of dUMP for TYMS dimer; (C) reaction process curves of dUMP for TYMS octamer; (D... | <Mentions>: [dump; mthf]
<Options>: A: tetrahydrofolates
B: 5-fluoro-2'-deoxyuridine-5'-monophosphate (aka fluorodeoxyuridylate)
C: n5,n10-methenyl tetrahydrofolate (aka 5,10-methenyltetrahydrofolate)
D: 2'-deoxyuridine 5'-phosphate (aka 2'-deoxyuridylic acid)
E: formyltetrahydrofolates
F: 5,10-methylene-5,6,7,8-tetrah... | [D; F] |
<Instruct>: Given the context '(A) Reaction process curves of dUMP for TYMS monomer, the left panel showing the substrate saturation curve, and the right panel showing the Lineweaver–Burk double-reciprocal plot; (B) reaction process curves of dUMP for TYMS dimer; (C) reaction process curves of dUMP for TYMS octamer; (D... | <Mentions>: [dump; mthf]
<Options>: A: tetrahydro-2'-deoxyuridine-5'-monophosphate (aka 2'-deoxy-tetrahydro-5'-uridylic acid)
B: deoxyuridine triphosphate
C: tetrahydrofolate (aka 5,6,7,8-tetrahydrofolic acid)
D: formyltetrahydrofolates
E: n5,n10-methenyl tetrahydrofolate (aka 5,10-methenyltetrahydrofolate)
F: ddump (a... | [J; G] |
<Instruct>: Given the context '(A) Reaction process curves of dUMP for TYMS monomer, the left panel showing the substrate saturation curve, and the right panel showing the Lineweaver–Burk double-reciprocal plot; (B) reaction process curves of dUMP for TYMS dimer; (C) reaction process curves of dUMP for TYMS octamer; (D... | <Mentions>: [dump; mthf]
<Options>: A: tetrahydrofolates
B: 2-methyltetrahydrofuran
C: uridine diphosphate
D: 5 fluoro 2' deoxyuridine 5' monophosphate (aka fluorodeoxyuridylate)
E: 3-mthf (aka meciadanol)
F: deoxy-utp (aka deoxyuridine triphosphate)
G: 2'-deoxyuridine 5'-phosphate (aka 2'-deoxyuridylic acid)
H: 5,10-m... | [G; H] |
<Instruct>: Given the context '(A) Reaction process curves of dUMP for TYMS monomer, the left panel showing the substrate saturation curve, and the right panel showing the Lineweaver–Burk double-reciprocal plot; (B) reaction process curves of dUMP for TYMS dimer; (C) reaction process curves of dUMP for TYMS octamer; (D... | <Mentions>: [mthf; dump]
<Options>: A: tetrahydrofolates
B: n(10)-methylfolate
C: 2'-deoxyuridine 5'-(alpha,beta-imido)triphosphate (aka 2'-deoxyuridine 5'-imidotriphosphate)
D: n5,n10-methenyl tetrahydrofolate (aka 5,10-methenyltetrahydrofolate)
E: deoxyuridine triphosphate
F: 5,10-methylenetetrahydrofolic acid
G: 2-m... | [F; J] |
<Instruct>: Given the context '(A) Reaction process curves of dUMP for TYMS monomer, the left panel showing the substrate saturation curve, and the right panel showing the Lineweaver–Burk double-reciprocal plot; (B) reaction process curves of dUMP for TYMS dimer; (C) reaction process curves of dUMP for TYMS octamer; (D... | <Mentions>: [mthf; dump]
<Options>: A: n5,n10-methenyl tetrahydrofolate (aka 5,10-methenyltetrahydrofolate)
B: 5 fluoro 2' deoxyuridine 5' monophosphate (aka fluorodeoxyuridylate)
C: 2'-deoxyuridine 5'-(alpha,beta-imido)triphosphate (aka 2'-deoxyuridine 5'-imidotriphosphate)
D: methanopterin
E: ddump (aka 2',3'-dideoxy... | [H; J] |
<Instruct>: Given the context '(A) Reaction process curves of dUMP for TYMS monomer, the left panel showing the substrate saturation curve, and the right panel showing the Lineweaver–Burk double-reciprocal plot; (B) reaction process curves of dUMP for TYMS dimer; (C) reaction process curves of dUMP for TYMS octamer; (D... | <Mentions>: [dhf]
<Options>: A: 5 alpha-dhf (aka 5-dihydrocortisol)
B: dicyanomethylenedihydrofuran
C: b(b)-dhf (aka benzo(b)-2,3-dihydrofuran-2-one)
D: 2,3-dihydrofuran
E: dihydrofolate, (d)-isomer (aka dihydrofolate)
F: None of the above. | [E] |
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