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fliara femaleled innovation in agriculture and rural areas | key contemporary trends such as climate change gender inequalities and the covid19 pandemic bring new challenges to european rural areas change also brings opportunities to foster more resilient inclusive and sustainable rural regions such as created by the digital and ecological transitions however there is a need for all individuals and communities to participate in rural innovation traditionally however rural womens employment opportunities and contribution to innovation has been overshadowed and often suppressed by for example a patriarchal ethos fliara femaleled innovation in agriculture and rural areas uniquely proposes a transdisciplinary innovative methodology to improve understanding awareness and recognition of womens role in a more sustainable rural future as well as develop proposals for how more effective policy and governance frameworks can support this and enhance womens capacity to contribute to it fliara will combine futures and case study methods alongside network building and policy benchmarking while being underpinned by a cocreated conceptual and assessment framework using a unique foresight approach fliara will identify visions for sustainable farm and rural futures and the sustainability innovations needed to realise these visions using a thematic casestudy approach project partners will investigate womenled innovations on farms and in wider rural areas looking at their pathways in the innovation ecosystem building on the power of social networks a community of practice will be developed with women identified throughout the case studies networking alongside key innovation policy and governance stakeholders the community of practice network will occur in conjunction with a campaign of visibility for womenled rural innovations spotlighting women as key innovation actors project outcomes will result in enduser ready resources including policy proposals and practical tools supporting womenled innovation |
nanocarbonionic liquidinterfaces for catalytic activation of nitrogen | ammonia is one of the most important chemicals in the world electrocatalytic reduction of nitrogen nrr at ambient conditions is a sustainable alternative for its production to the established energy consuming haberbosch process relying on hydrogen from fossil sources the triple bond in dinitrogen is one of the most stable covalent chemical bonds conversely the dissociation of dinitrogen and its chemical conversion is highly demanding nrr is a carbonneutral and decentral process that can be carried out wherever renewable electricity water and air are available however current research on nrr and other electrocatalytic reactions has reached an impasse as improvements based on catalyst design are getting more and more incremental at this tipping point cilcat tackles a foreseeable stagnation by constituting a disruptive principle that holds holistic perspectives for the activation of small molecules the novel concept will go beyond established principles of isolated catalytically active sites by confining ionic liquid il electrolytes into charged porous carbon materials an interface will be created that as a whole serves as catalytic surface cilcat will contribute to a fundamental understanding of the physicochemical principles of sorption into ils upon confinement in pores targeted catalyst development will follow and the possibility of using the principle for catalytic activation of nitrogen and other molecules will be explored this innovative approach will then be combined with advanced electrode design cilcat aims for more than a step towards a future carbonfree nitrogen economy it is a pioneering attempt to heterogenize homogenous catalysts by rather converting the energy principles of small molecule activation than chemical structures from solution to surfaces the methodology is transferable to other obstacles in the field of catalysis and the project will lead to a more objective general understanding of reactivity in confined spaces |
controlling delocalisation and funnelling of excited state energy in the strong coupling regime in molecular systems | a fundamental physical property of a fundamental physical property of matter is its ability to interact with light this is not only the basis of fascinating concepts like seeing colours but also the foundation of life and advanced technologies yet some basic physical laws hamper possible utilisations it is therefore of great importance to examine how to bend these laws how to bypass them and by so doing open up new opportunities for novel applications this is exactly what this project aims to doplant leaves are green because they absorb visible light however it is less known that this lightmatter interaction can be enhanced to the point where it is so strong that the photon and molecule cannot be regarded as separate entities but as a combined system with unique properties nature uses strong pigmentpigment interactions to rapidly funnel absorbed sunlight to the photosynthetic reaction centre however up to now organic solar cells do not take advantage of such quantum processes to enhance light to electricity conversionin control i will use a chemical viewpoint to develop unique molecules optimised for strong lightmatter interactions and with these examine excited state processes of strongly coupled systems my aim is to funnel excitation energy to charge transfer states in an organic heterojunction using the delocalised nature of hybrid lightmatter states this interaction enables transport of excitation energy over distances much longer than have been previously considered feasible using timeresolved optical spectroscopy and photoconductivity i will systematically analyse the interaction between delocalised hybrid states and localised charge transfer states allowing design criteria to be formulated the outcome of this research program will be the description and mechanistic revelation of a novel quantum physical phenomenon that can enable development of organic solar cells from simple layered structures with unprecedented efficiencies |
children of the barbaricum short lives early deaths on the eastern fringes of the roman world | children have vulnerability to morbidity and mortality which in turn influence the social structures around these especially susceptible periods the study of past childhood frailty and survival is still very much relevant today especially for children from the edges this project examines the health status of the sarmatian children from the barbaricumthe area beyond the roman frontier the written sources of classical antiquity paint the sarmatians as nomadic people of the steppes between the ural mountains and don river who migrated west and settled in the carpathian basin and on the great hungarian plain occupying parts of modern romania and hungary for over four hundred years while the greek and roman authors described these populations as skilled equestrian warriors hostile and destructive caught in a cycle of war and peace with the roman empire little is known about the biocultural challenges their children had to face living in the barbaricum during the roman age by utilizing interdisciplinary investigations this project integrates data models and theories from bioarchaeology archaeology palaeoproteomics growth and development and ethnohistory in order to deliver a life course approach to childrens health offer a bioculturally informed perspective on gendered differences in direct and structural violence and reconstruct dietary habits at different life stages as children transition into socially adult roles with the onset of puberty according to the who of the 52 million deaths that still occurred among children 5 years of age in 2020 many were concentrated in vulnerable populations by adopting a life course approach within a biosocial framework the project hopes to highlight how the past can inform the present and hopes to show how work carried on precious ancient tiny bones and teeth could contribute to the global efforts to improve the health and wellbeing of children and adolescents today |
growing long distance rna control of neuronal extension | neurons are the longest cells extending axons over distances that can reach four orders of magnitude larger than their cell body diameters how can they achieve such long distance growth after initial engagement with target cells neurons undergo stretchinduced elongation as the nervous system matures with the growth of the organism the molecular mechanisms enabling such prodigious growth are unknown based on strong preliminary evidence we tested the hypothesis that both the initial elongating and later stretchinduced axon growth act via a shared rna localization mechanismvery strikingly we identified a specific subset of polyadenylated repeat element rnas hereby termed growthinducing sines gisines as key growth regulators gisines are induced from ap1 promoterassociated extragenic loci and interact with ribosomal proteins and the axon growth regulating rna binding protein nucleolin in neuronal cytoplasm we will elucidate how this intrinsic mechanism controls neuron growth determining 1 how known elongating growth regulators affect stretchinduced growth 2 how local and global protein synthesis regulate neuron growth control and 3 how growth regulates the gisines and how they regulate different growth modalitieswe will apply a multidisciplinary suite of techniques and approaches to these challenges including a new technology for characterization of nascent proteomes developed inhouse the proposed project will provide groundbreaking and fundamental mechanistic insights on neuronal growth and will establish novel methods that will be widely applicable moreover establishing that a repeat element rna is an intrinsic effector linking ap1 transcription to translation regulation is a breakthrough finding that opens new horizons for cell biology and neuroscience |
european union contest for young scientists 2023 | the present proposal is relevant to the organization of the 34th edition of european union contest for young scientists eucys to be held in brussels belgium in september 2023 since 1989 eucys has been organised in countries across europe with the aim of promoting science and research in different countries and bringing research and young talents into spotlight in these countries the young scientists also have the chance to meet others with similar abilities and interests and to be guided by some of the most prominent scientists in europe this way eucys seeks to strengthen the efforts made in each participating country to attract young people to careers in science and technology the jeunesses scientifiques de belgique jsb the belgian eucys national organiser shall host eucys 2023 and be responsible for the organisation of the event jsb objective is to take on the great opportunity to welcome the european brightest young scientists in europe the organising committee has built a large experience hosting for 37 years the belgian national exposciences eucys 2016 the milset exposciences europe 2000 and the milset exposciences international 2015 esi2015 event that brought together 1000 participants from 60 different countries it will be a unique opportunity to welcome this prestigious event in brussels the european capital and to interact with all european dimension of the host city and region by activating jsb large network of schools professors and students and as well promoting the vent within the european institutions eucys will contribute to greatly enlarge the impact and visibility of the eu science promotion |
green engineering analysis reskilling for unbounded production | the gearup proposal is a comprehensive initiative to revolutionize the manufacturing sector through sustainable practices and advanced technologies the projects central objective is to develop digital tools and methodologies that address recycled materials variability it covers stainless steel aluminum alloys and fiberreinforced plastics for additive manufacturing am it employs simulationdriven approaches for optimizing various am processes including laser beamdirected energy deposition metal laser beam powder bed fusion and fiberreinforced polymer material extrusiongearup also emphasizes environmental conservation by using recycled materials in engineering design significantly reducing virgin resources energy consumption and greenhouse gas emissions the project intends to overcome challenges associated with secondary materials such as performance variability through resilient design and lifecycle environmental impact assessmentmoreover the proposal outlines ambitious objectives for enhancing sustainable product design using innovative simulation and modeling software it also implements the digital product passport initiative and fosters human involvement in advancing circularity and sustainable technology adoption this is done through training and global collaborative networks gearups approach represents a paradigm shift in engineering design focusing on the circular value chain and developing universally adaptable am technologies resilient to material variability this endeavor is expected to directly impact the highperformance consumer products green energy hightech robotics markets the key outcomes arecost savings 25 increased productivity 2050 extended fatigue life 5080 defects reduced 5080 material waste reduced 2530 co2 emissions reduced 2550 reduced quality failures 7090 reduced design time 2050 reduced component weight 2530 |
novel bipolar membraneelectrode assembly designs for simultaneous co2 capture and reduction | the discovery of efficient technologies for mitigation of the rising co2 level and the associated energy and environmental issues isthe grand challenge of our time electrochemical co2 reduction eco2r is one promising approach to convert co2 into valuableproducts but the practical realization is still limited by material and systemlevel challenges on top of this the pathway to bring co2captured from a point source to an eco2r site involves energyintensive practically difficult intermediate steps often overlooked bythe research community the battlecapco2 project introduces a new pathway to fully integrate co2 capture and co2 reductionco2cr in a unit flow reactor this will be achieved by a unique design of bipolar membraneelectrode assemblies obtained bycoupled 3d printing and photolithography techniques an attempt will be done to elucidate the impact of bpm interfacemorphologies and electrode surface properties on the efficiency of co2cr the conceptual flow reactor design allows forsimultaneous co2 capture in situ regeneration and subsequent electroreduction into useful chemicals presenting an energy efficient and costeffective technological solution the action will broaden the knowledge and expertise of the researcher through highquality research training in the field ofcarbon capture and utilization involving multidisciplinary investigation approaches and intersectoral secondments this will allowhim to expand his professional network with leading scientists in academia and industry from across europe and the globe andacquire key skill sets towards professional independence the project will provide new technological solutions with a significantimpact on the ambitious europan green deal aiming to transform eu into a resourceefficient and competitive economy ensuring aclimateneutral society |
a genetic engineering approach for lignification of cell walls from moss to develop novel woodlike biomass | in the current context of climate change transitioning from a petroleumbased economy to more sustainable alternatives is of top priority wood is one of the most abundant renewable resources with established roles in the furniture construction paper and energy sectors because of this demand for wood is increasing as policies around the world promote energy generation from wood risking increased deforestation and exchange of diverse forests for monoculture plantations the industrial applications of wood depend on its composition specifically that of lignin in the secondary cell wall scw although much is known about lignification through extensive research on arabidopsis thaliana and other vascular plants there are still knowledge gaps involving the initiation and control of lignin polymerization that remain to be addressed in order to outline the core set of genes associated with the emergence of ligninin these lines the longterm goal of this proposal is to engineer innovative woodlike biomass by introducing ligninbiosynthetic genes in fastgrowing moss to establish new types of biomaterials potentially reducing the use of wood in certain applications and alleviating increasing pressures on forestsmosses are land plants lacking lignified vascular tissues but have homologous genes to most steps in lignin biosynthesis we hypothesize that the lack of lignin in mosses makes them potential model systems to determine how lignin polymerization and scw formation occur in plantsin this proposal we will systematically transform the model moss physcomitrium patens with genes from vascular plants until canonical lignin is observed in its cell wall the outcomes of this work will pave the way for innovative biomass sources and potentially provide insights into tailoring lignin composition and transferring such knowledge to existing agricultural biomass this approach also promises to become a powerful tool for basic research in the study of lignin |
regulatory frictions as spaces of innovation frictions centring the transformative administrative practices of smallscale cultural initiatives as empowering tools to engage with the climate crisis | frictions investigates the substantial gap between european policy commitments for a climateneutral economy and the reality on the ground for small initiatives across europe who are making transformative endeavours for climate action in their own communities but face regulatory systems that do not fit the visionary work they do frictions engages with this impasse at a practical level through the daytoday practice of administration as a place where new innovative procedures relations and ways of thinking about regulation can be imagined and forged the research approach departs from notions of progress and modernity that characterise much of transition discourse to concentrate instead on systems change at the microlevel of habit everyday process and experience with particular focus on procedural spaces and relationships where things often feel stuck drawing on my research practice as an artistactivist working across art business and social fields the research objectives are to 1 unearth illuminate and negotiate the kinds of regulatory frictions that small sustainablyminded organisations regularly encounter and the innovative actions they are already making 2 design creative experiments in administrative practice for how such organisations can prefiguratively navigate complex regulatory systems across different eu jurisdictions and 3 establish new channels procedures and vocabulary to promote innovative administrative practice as a transformative means to strengthen and sustain cultureled innovation for the eus critical ecological transition to achieve these objectives frictions will engage methods from participatory action research and tactical art working collaboratively with 3 exemplary smallscale cultural initiatives nlsihr and establish a new research centre the institute for experiments with business ibex as a platform to continue this work beyond frictions |
non binary genius intellectual hermaphroditism and androgyny in spain 18921939 | geniuses have fascinated generation after generation whether for their artistic achievements or their political work however what really constitutes genius is a question that remains undetermined though it is associated with a high level of intelligence scholars from the 19th and 20th centuries argued that it took something else to be a genius intellectual hermaphroditism and androgyny were considered key aspects for the development of genius because of the benefits that both male and female traits could have for the equilibrium of the mind this project focuses on the relationships between sex and genius in spain from 1892 to 1939 i will explore how experts conceived sex differences for the explanation of genius and analyse the case of hildegart rodrguez a famous spanish child prodigy who was specifically conceived and raised to become a genius and was later murdered by her own mother there have been studies on genius and child prodigies that worked on the importance of genius for social progress and the lack of women genius this project will go beyond these studies by shedding light on a nonbinary conception of the mind through the approach of intellectual history cultural history and gender studies i will work on three research objectives 1 examine intellectual hermaphroditism or androgyny in the study of sex differences in relation to intelligence 2 discuss how a nonbinary conception of genius contributed to the nature vs nurture debate 3 analyse correspondence and personal writings by hildegart rodrguez overall this project aims to empower women and nonbinary folk by investigating their historical role in the production of scientific knowledgemy strong background in history of psychology particularly in the study of intelligence and the circulation of psychological knowledge combined with my supervisors expertise and the host groups work will ensure the successful implementation of this project |
superresolution magnetic correlation microscope | over the past several decades the microelectronics industry has revolutionized nearly every aspect of our lives the evergrowing need for faster and more efficient devices recently emphasized by the extreme computing requirements of artificial intelligence techniques is pushing traditional device architectures to their limits prompting the search for novel physical realization of such devices currently the most promising approach involves magnetic materials as can be witnessed through the recent advent of magnetic memories as well as development of logic devices based on hybrid electronicmagnetic structures and the flow of magnetic charge referred to as spintronicsdespite the tremendous progress achieved the field of spintronics is held back by both fundamental and practical open questions related to issues such as magnetization switching and excitation dynamics effects of magnetic and topological defects and local conductance properties of magnetic devices a major obstacle encountered in addressing these important open questions stems from limited measurement and characterization techniques highresolution sensing of dynamic response and conductance cannot be achieved with existing nearfield toolsi propose a new kind of microscope a farfield superresolution magnetic correlation microscopy platform building upon progress in the field of magnetic microscopy using defects in diamond including our recent results studying chiralmagnetic hybrid devices this unique platform will constitute a leap forward over stateoftheart magnetic sensing techniques it will enable for the first time local nanometer scale magnetic correlation data unattainable by other means i will employ these groundbreaking capabilities to reveal the dynamics related to excitation creation and control in 2d magnetic materials and currentspin conductance leading to breakthrough magnetic device architectures |
carbonhydrogen bond activation via a new charge control approach | organic synthesis stands as the beating heart of technological and societal advancement driving breakthroughs in drug discovery agrochemistry materials design and the pursuit of a more sustainable world in a world where ch bonds are the main functional groups available the field of ch functionalisation has experienced exponential growth over the past two decades while stateoftheart methods have led to remarkable achievements they remain confined by the dominance of substratecontrolled reactions driven by directing group logic and by being largely reliant on precious metal catalysts chance proposes to open a new page in ch functionalisation exploiting the emerging concept of charge control as a mode to influence and steer reactivity of ch bonds this will usher in a new logic for ch bond functionalisation where reagent control can address substrates devoid of directing groups and where entirely novel reactions will emerge this will not only reshape our fundamental understanding of ch functionalisation but also yield valuable products for downstream applications given my unique expertise and documented trackrecord of achievements especially in the exploration of outofthebox nonmainstream fields of synthetic chemistry i am in a unique position to lead in the unfolding of this new era |
nextgenbiopest next generation biopesticides for the control of the most difficulttomanage pests and pathogens in fruits and vegetables | plant pests and pathogens damage agricultural production and endanger food security their control relies heavily on the use of synthetic insecticides leading to a negative environmental impact developing new methods for pest and pathogen control is therefore essential to safeguard human health and meet the challenge of increasing crop yields while reducing the use of chemical pesticides the overarching objective of the nextgenbiopest project is to meet this need by delivering novel and improved products methods and practices for the rational control of the most difficulttomanage arthropod pests and pathogens with substantially reduced pesticide use the project will provide a new toolkit for plant protection in key vegetable and fruit crops including diagnostics for pest and pathogen identification and incrimination novel biological control agents and methods to augment their performance in the field rnabased pesticides low riskgreen chemicals plant resistance inducers and innovative agronomic and ecological practices these innovations will be integrated with existing approaches to achieve effective environment friendly and sustainable crop protection they will be validated in large field studies with both their efficiency and socioeconomic impact assessed demonstration fields extensive training and modern targeted communication channels will enable the appropriate dissemination and uptake of the outcomes to the stakeholders and end users data protection and commercialization strategies will ensure their exploitation these goals will be achieved by integrating leading institutional and industrial partners with drivers of pest control programs the multidisciplinary and multiactor team will exploit their diverse expertise access to extensive preliminary data and resources and strong networks to meet the project objectives and ensure the knowledge and tools generated deliver economic ecological and societal impact |
nextgeneration models for advanced battery electronics | nemo project aims at advancing the state of the art of battery management systems bms by engaging advanced physicsbased and datadriven battery models and state estimation techniques towards achieving this goal the consortium tends to provide efficient software and hardware to handle host process and execute these approaches within highend local processors and cloud computingnemo benefits from a wide range of sensor information acquired at high frequencies in addition to dedicated electrochemical impedance spectroscopy eis sensors which allow for the identification of ongoing electrochemical reactions inside each individual battery cell capable hardware for storing and processing such measurements will be provided by the tier1 members of this industry onboard the consortiumthe availability of such diverse physical information on batteries onboard makes room for developing cuttingedge performance lifetime and safety battery models and state estimators within nemo and validating them on two different bms configurations physicsbased performance model parameters continuously get updated as the battery ages so that performance and safety state indicators maintain the least possible error the datadriven approaches exploit mathematical algorithms to be trained upon the large datasets made available from historical or laboratorygenerated battery information combinations of coupled physicsbased and datadriven approaches are also foreseen to be implemented within nemo as another innovation of the project to propose nextgeneration bmssolutions offered by nemo considerably extend battery life and make the battery system safer within longterm operation since every individual cell is monitored controlled and studied nemos ambitious solutions for stationary and automotive use cases are expected to be validated by industrial partners and to take a considerable share of the market in later years |
shedding light on the key molecular determinants regulating 3d diffusion and activity of antimicrobials in bacterial biofilms | bacterial biofilms are associated with approximately 17 million hospitalacquired infections annually in the united states incurring an annual economic burden of about 11 billion dollars the role of biofilms in antimicrobial resistance amr is highly complex and may significantly drive resistance biofilms can act as a diffusionlimiting barrier against various antimicrobials resulting in limited drug access into the bacterial cells the evaluation and quantification of biofilm diffusion is essential since it is a poorly researched topic and the matrix properties are necessary to define the bacterial populations within the biofilm in this project an antimicrobial peptide amp will be used as a model molecule because amps are known for their activity against biofilms and have been considered promising antibiofilm agents the vcpp2319 a peptide developed by the instituto de medicina molecular team imm was chosen for the project as a diffusion model reporter the research plan is organized into three scientific work packages wp wp1 aims at studying the fundamental properties of biofilms whereas wp2 and wp3 aim at studies using vcpp2319 and the library of its variants respectively as molecular models to elucidate their diffusionrelated properties in biofilms and correlate antibiofilm activity with the metabolic status of biofilmembedded bacterial cells the project will use two reference and two clinical strains of staphylococcus aureus and klebsiella pneumoniae as models these bacterial species will be selected because they are clinically relevant pathogens frequently associated with biofilm infections overall the projects relevance is overcoming the gap of knowledge associated with molecular diffusion in biofilms and relating the diffusion of antimicrobials within biofilms with their activity this will enable the future development of innovative chemotherapies to fight against biofilmrelated infections |
modular axial flux motor for automotive | the massive electrification of automotive vehicles will necessarily involve the development of low cost highly compact and low environmental impact electrical machines em the objective of the maxima project is to develop and validate a complete methodology to design an em as well as the associated production system for the automotive core market this methodology will have to deal with often incompatible constraints such as efficiency costs reduction high performances in terms of powertorque density and high recyclability especially for critical raw materials to achieve this objective maxima will focus on a dedicated topology axial flux synchronous machine afsm asfm currently on the market are very efficient but cover only a niche market due to their high manufacturing costs they also offer strong exploited or unexplored options in terms of topologies and materials unlike radial flux ems the margin for improvements of afsm is really significant by acting on both em design and manufacturing process flow thus allowing higher performances and lower cost while keeping a low environmental impact the consortium brings together research teams and companies from the entire value chain from raw material suppliers to car manufacturers along with a recycling company together they can face the main technological and scientific challenges in the electromagnetic mechanical and thermal fields reaching a solution close to market at the end beside high trl5 prototypes the project will provide a validated methodology to accelerate the design thereby reducing the time to market and new technologies such as em digital twins to operate ems to their full potential |
optoelectronic neural connectoid model implemented for neurodegenerative disease | a major challenge facing europe is its ageing population and associated increase in diagnosed cases of neurodegenerative diseases ndd parkinsons disease pd is associated with tremor and loss of motor functions due to progressive degeneration of dopaminergic neurons in the brain this can lead to memory loss and dementia which is associated with short and longterm injuries and disabilities with emotional financial and social burdens for patients families and society the exact causes and mechanisms underlying pd are still unknown and existing treatments focus on alleviating symptoms and increasing quality of life but do not halt or reverse disease progression although animal models give unique possibilities to study physiological and behavioural mechanisms drug development fails due to lack of translation to humans alternative nonanimal ndd models is needed both in terms of better translation but also to replace expensive and problematic animal experimentswe will move disease modelling to a new level and replace animal models by creating a new concept we call connectoids we will develop an exvivotype in vitro human optoelectronic multiregional brainorganoid disease model in which connectoids are formed by precise spatial arrangement of brain organoids connected via hydrogel tracts that promote axonal pathfinding functional connection and signalling by developing 1 light controllable subtype specific neurons within regionalized brain organoids and 2 electrodes and waveguides that can penetrate the organoids able to monitor neurotransmitter signalling inside and between the organoids we will for the first time be able to sense how a particular brain region responds to a certain therapy and watch in real time how signals are transmitted to other brain regions our model will not only have health benefit but will relieve a heavy economic burden on society and open up for new possibilities for technological and economic development |
innovative strategies for containership fires prevention and management | maritime transport represents the centre of global trade with about 90 of the goods volumes and values worldwide nowadays containerships are built with the same basic design principles as the older smaller container ships without accounting for possible consequences that could impact safety cargo fires represents one of the most important threats of this kind of ships also for ferries with container on the truck on one hand fire causes large losses of humans andor cargoes on the other hand fire is impacting coastal zone and marine protected areas currently there are no requirements for the installation of fixed fire detection systems above the weather deck of a container ship innovative strategies for containership fires prevention and management overheat main goal is to prevent and manage in case of occurrence fire accidents on board of containerships overheat brings novel fire management solutions for prevention early detection and response which are key aspects to assure safety of people and the protection of the environment the development of a digital solution ds will provide the overall situational picture on board and surrounding the vessel furthermore integration of iot sensors fixed and mobile and uas will provide the adhoc system for the prevention early detection and rapid response of fire best practice and assessment of safety culture will be conducted to prevent fire and understand how people perceive safety hence overheat prepares a truly new generation of digital fire management solutions complete seamless real time and in line with imo regulations integrated in the vessel it infrastructure the impact of the proposed solution will be initially evaluated by performing validation activities in simulated environment and then executing demonstration activities in a real environment with use cases that will be identified described and detailed during the research activities to prove the feasibility and benefits |
improving micropollutants analysis and controlling of terrestrial and aquatic systems | degradation of plastics is a sequence of chemical and physical changes reducing their molecular weight and mechanical integrity of the polymer and leads to formation of microplastics mps negative effect of the mps on the environment is not only physical but also chemical due to their ability to adsorb and accumulate many persistent organic pollutants the role of mps as a vector of the contamination is newly formed phenomenon and could fundamentally top off the role of mps in the ecological systems only limited number of scientific papers and research are currently available and published thus impactas project aims to change it university of las palmas de gran canaria provides unique opportunity to study micropollutantsmicroplastics topic in terms of islands location extensive tourism industry protected natural parks excellent infrastructure and knowledge of environmental analytical chemistry research group belonging to institute for environmental studies and natural resources project will focus at few objectives development of analytical methodologies and strategies for the determination of organic pollutants adsorbed on mps spatial and temporal monitoring of micropollutants microplastics in different environmental compartments and environmental risk assessment of micropollutants in different natural ecosystems objectives of the project are multidisciplinary including combination of analytical chemistry statistics biology and environmental sciences impactas implies international research visits and placement of the researcher for further knowledge implementation expected results have potential to provide state of the art solutions for micropollutants monitoring and control in different environmental and biology systems around canary islands which could be transferred across research groups within eu countries this project is in line with the eu strategy for plastics in a circular economy and blue growth strategy of the european union |
preclinical in vivo validation of a glioblastoma neuro snooper electrical device | median survival for people that are diagnosed with glioblastoma gbm is only 15 months chemoradiotherapy and targeted therapies still fail to combat peritumoral relapse after tumour removal preventing peritumoral brain invasion is the main target to cure gbm our project aims to validate a proofof concept for a new medical device md gbm neuro snooper in gbm animal models a required step before initiating a clinical trial technology readiness level from 23 to 4 this md will allow to define an insitu electrophysiology profile of patients with gbm after the tumor resection to access a new mechanistic understanding in the brain tumour field as well as new strategies for patient stratification and treatment already existing mds with electrode wires are either very stiff or with a millimetric dimension the erc work will lead to a first generic miniaturised prototype implant with moderate invasiveness and which design was validated in connection with neurosurgeons for the gbm application validation of its freedom to operate in the context of continuous ip landscaping and the creation of an exploitation plan in a longterm perspective it will help characterise hyperexcitability in brain diseases such as tumors but also epilepsy or the alzheimer disease we will also investigate the effect of stimulation of the peritumoral tissue and the correlation with the recorded signals as a new electrotheragnostic strategy we will address the ethics and social dimension of using such a md and our exploitation plan will include the protection of intellectual property business strategy and the preparation of a clinical trial after project completion the project will be performed by a dedicated team that includes significant expertise in technical development preclinical validation of devices surgery and knowledge transfer |
disrupting the horticulture industry with smart lighting solutions | artificial lighting systems are holding back wide adoption of vertical farms due to 1 high energy costs and 2 inability to fully replicate the sun spectrum it also affects greenhouses profitability as they also depend on artificial lighting systemsminisun is the most energyefficient lighting system for the horticulture industry 50 reduction compared to existing technologies able to fully mimic the sun spectrum based on groundbreaking luminaires that combine proprietary led and smart driver technologies with stateoftheart sensors and aiml algorithms with minisun indoor farming becomes profitable for a variety of crops eg cucumber berries tomato pepper making it possible to grow them in vertical farms for the very first timeour circular business model low capexopex recurring revenues over time will enable rapid growth our vision is to become a world leader in the horticulture led lighting market addressing a 10 of the market share by 2030 |
nanoengineered photoactivated drugfree antimicrobial precision treatment for chronic skin wounds | antibioticresistant bacterial skin and soft tissue infections sstis are difficult to diagnose and treat prolonging hospital stays and lowering quality of life chronic wounds harbour antibioticresistant microorganisms that form biofilms leading to conditions like diabetic foot ulcers dfus approximately 50 of dfus become infected making them the most prevalent and costly diabetes complication with a higher mortality and morbidity risk from lower limb amputation there is an urgent need to develop effective localised solutions for treating sstis that do not depend on antibiotics especially against complex biofilms like those occurring in dfu casesin this proof of concept project we will evaluate a photocure wound patch a porous nanothin agtiox film with visiblelight photocatalytic activity that produces superoxide radicals to effectively eradicate biofilms in the sstis context the patch boasts enhanced mechanical stability for durability and sustained activity across multiple irradiation cycles offering a viable option for recurrent treatment photocure patch presents a more efficient drugfree alternative to conventional antibiotic treatments with reduced adverse effects addressing the escalating challenges of antibiotic and multidrug resistancethe project will validate the antimicrobial efficacy of tioxpolymer nanocomposite patches against both single and multiplespecies biofilms relevant to chronic sstis notably dfus using ex vivo and in vivo humanrelevant models subsequently we will devise a comprehensive ip strategy secure initial patents and conduct thorough market and competitor analyses within the antimicrobial wound care dressing sector finally we will outline a detailed business case for advancing the photocure prototype to market |
quantifying the formation and evolution of the archaean lithospheric mantle | the formation of the archean lithosphere was a key event in earth history resulting in the construction of the first continents or cratons the lithosphere formed by extensive mantle melting however there are conflicting models for the environment in which melting took place efforts to understand the formation of the cratonic lithosphere are hampered by a lack of quantitative information on the depth of mantle melting and the original thickness of the archean lithosphere exsolved orthopyroxenes within peridotite xenoliths and silicate inclusions in diamond hold the key to constraining these critical parameters we will reconstruct the original compositions of an extensive collection of exsolved orthopyroxenes and use our recently published thermodynamic model to calculate their formation pressures and temperatures this innovative approach will reveal the depth extent of archean melting we will provide the first constraints on the vertical extent of the lithosphere in the archean using geothermal gradients calculated from dated diamond inclusions to achieve this we will perform cutting edge laser ablation upb dating of garnet inclusions this challenging application has yielded promising results for xenolithic garnet observations will be complemented by new experiments using fertile depleted and silicaenriched compositions coupled with with thermodynamic modelling which will lead to a better understanding of phase relations during peridotite melting the origin and significance of silica enrichment is poorly understood we will conduct meltrock reaction experiments to test the hypothesis that silica addition occurred via interaction with ascending komatiite melt we will thus address several fundamental issues the depth of archean mantle melting the origin of silica enrichment and the link between cratonic peridotite and komatiite magma litho3 will provide unprecedented insight into the formation and evolution of the cratonic lithosphere |
3d cuprate twistronics as a platform for high temperature topological superconductivity | 2d superconductors can be used to build ultraclean interfaces for josephson junctions the superconducting analog of a transistor a small twist in the relative crystal orientation of 2d superconductors could become a new platform for topological superconductivity an exotic state of matter that holds great promise for quantum computing at high temperatures based on my methodological developments for the realization of twisted cuprate ultraclean interfaces the field is rapidly evolving and these interfaces are now the leading candidate for the implementation of hightemperature topological superconductivity however the combination of wellcontrolled twisted cuprate heterostructures and complex circuits calls for new experimental methodologies3dcut will develop micronanodevices and techniques to fabricate and control cuprate van der waals twisted heterostructures in threedimensional nanoarchitectures 1 we will develop novel fabrication tools to integrate complex thermal and superconducting circuits in fragile twisted cuprate bilayers we will explore if a topological gap opens near magic angles in twisted bilayers by studying the josephson effect 2 we will fabricate trilayers cuprate heterostructures with different twist angle symmetries where the topological gap is amplified and timereversal symmetry broken states appear across a wide range of angles 3 we will create a heterostructure between a superconducting cuprate twisted heterostructure and a topological insulating crystal allowing us to create a chiral majorana edge mode at the end of this project we will have provided a brandnew solidstate tool for emerging quantum technologies in computation metrology secure communication singlephoton imaging methodologies for the entire field of 2d materials and a comprehensive understanding of the governing principles and ingredients for topological superconductivity at high temperatures |
ice shelf damage characterization and monitoring around antarctica | the ice shelves of antarctica act as giant dams limiting ice flow from the interior into the ocean recently several of these dams have shown dramatic signs of damage once the ice is fracturing the dam is weakened allowing the ice to flow faster and increasing mass loss from the interior of the ice sheet which results in an accelerated contribution to sealevel as antarctica is the largest reservoir of fresh water correctly predicting its evolution is crucial to anticipate when and how much sealevel will rise damage is currently absent from projection of antarctica evolution because of the difficulty of representing this process in numerical models as well as the lack of observation to constrain them the aim of the icedam project is to quantify and understand the evolution of damage on ice shelves around antarctica my team and i will first use a novel approach based on deep learning to automatically identify the evolution of fractures and their characteristics on satellite imagery by combining this record with inversions from a highorder ice flow model we will quantify the links between fractures and changes in ice rigidity which controls the strength of ice shelves to better understand the damage variability we will measure the evolution of key variables that positively impact the rheological weakening of ice shelves these time series will be analyzed in a unique fashion to determine the major processes that led to the evolution of damage in the satellite observation era based on these results we will set up the first sentinel of ice shelves by systematically mapping the evolution of fractures in near real time this will be used to establish new vulnerability indices based on changes in ice rigidity and their impact on glacier mass balance this project will open a new window on the processes affecting ice shelves at an unprecedented level of resolution ultimately allowing us to improve our ability to predict the fate of sea level rise |
holistic framework for the maturity evaluation of readiness level for security technologies | in the recent years there are plenty of metrics that try to evaluate the maturity of productssystemsprocesses when identifying their deployment readiness even though an excessive effort has been made to integrate widely used frameworks methodologies and indicators in the productssystemsprocesses this leads to a limited usage from the eu funded security ri projects as a result a robust scaling framework is more than of utmost importance the proposed multirate scaling framework will rely on the existing established readiness level approaches and will formally combine them into one acceptable and reliable framework multirate will be able to evaluate and apply the readiness of all aspects of productssystemsprocesses it will make a thorough research on the existing methodologies and will develop a wellestablished scale taking into consideration several areas of knowledge such as technology readiness level trl scale integration readiness level irl commercialisation readiness level crl manufacturing readiness levels mrl security privacy and ethics readiness level sprl and societal readiness level srl these rls will set the basis for the creation of the holistic multirate framework that will evaluate the readiness of all aspects of a productsystemprocess the experience gained from previously proposed and ongoing maturity evaluation solutions developed and will be proposed under eufunded projects will lead to the multirate robust holistic framework solution of great importance will be the establishment of a network of projects and organisations that will support the design of the appropriate evaluation methodologies adding also their knowledge and expertise on the calibration and testing of both individual rls and the holistic one this network will be built based on the partners involvement on existing networks and eu funded projects |
communitycentred language revitalisation powered by heritageled storytellling and digital innovation in europe | languages are part of our shared cultural heritage and gateways to european multicultural identity within this framework endangered intangible heritage and language eihl communities hold unique traditional knowledge that supports a distinct sense of placemaking and long traditions of cultural and heritage sustainability within some of the most vulnerable ecosystems although digital technologies provide a uniquely powerful opportunity to revitilise eihl previous efforts have predominantly concentrated on preserving grammaticallexical aspects there remains untapped potential in exploring the integrated use of immersive technologies and participatory storytelling for linguistic heritage revitalisation through active community engagementrevive will identify and evaluate the role of digital innovation creativity and interactive narratives in promoting understanding and engagement with eihl fostering social integration and crosscultural fertilisation among marginalised european communities the project will be based on two concrete case studies and cultural contexts cornish uk and griko italytaking advantage of xr extended reality technologies revive will produce the first eu online digital scaffolder so called revives comprising a an online repository and showcase of old material testimonies collected by locals and new xr digital narratives and b onsite temporary exhibitions made of micro and macro outputs born out of revives and setup in selected communities venuesthese activities will inform policy recommendations best practice guidelines and toolkits for eihl revitalisation aligning with revives main goal demonstrating that citizen participation multidisciplinarity and the creative connotation of digital innovation are crucial and effective means for consolidating and promoting multilingualism and eihl in europe |
powering satellites by a combination of solar and microwave energy harvesting | powersat focuses on scavenging the unexploited solar infrared ir spectrum by providing an original thz 10400 thz energy harvesting platform thus completing the function of photovoltaics cells and on harvesting the microwave spillover losses from satellites antennas and transform them into a dc power supplypowersat will deliver an original solarmicrowave combined platform based on rectennas to harvest a big part of the ir radiation coming from the sun and the spillover electric field radiated by satellites antennas in four main bands ie cband 48 ghz xband 82124 ghz kuband 1218 ghz and kband 1827 ghzthis harvested energy will be employed to fuel the lowpower embedded electronics within satellites including components like lownoise amplifiers various sensors and oscillators moreover antennas designed for energy harvesting can also facilitate efficient and lowpower intersatellite links isls satellites are often arranged in constellations flying in formation as they orbit earth in such configurations satellites can establish communication links with neighboring satellites using rf or laser links these isls enable satellites to connect with others allowing data to traverse different gateways within the satellite network to achieve this powersat will propose five demonstrators ie a solar energy harvesting platform integrating micronanoantennas and mim diodebased rectifiers and four demonstrators integrating several rectennas each demonstrator being suitable for one of the four microwave bands mentioned before these same antenna arrays will be instrumental in enabling lowpower backscattering communications the final goal is to provide a seamless integration of the newly developed rectennas into satellites electronic systems which in perspective will allow the future partial replacement of satellites solar cells thus lowering satellites overall weight and hence the launch costs |
m80 an hybridelectric regional commercial aviation aircraft | sustainable aviation is important for the eu denmark and sweden have set a target to achieve 100 fossilfree domestic flights by 2030 given that developing a new aircraft typically takes 810 years it is imperative to commence work immediately if the eu intends to meet its environmental and sustainability objectives including zeroemission aviation funded by the european investment council the maeve m80 project is dedicated to the creation and commercialization of the worlds first hybridelectric aircraft for the commercial aviation market capable of decarbonizing existing flight routes in the regional aviation segment its maeves mission to reduce more than 50 mt of co2 from commercial routes before 2040 m80 can accommodate 80 passengers and cover distances of up to 1482 km and is aimed for entryintoservice in 2031 |
onchip energy harvesting and management enabled by thermal engineering of twodimensional materials | twodimensional 2d van der waals layered materials have been acclaimed for their great potential in several fields of condensed matter physics as applications are starting to appear increased effort is dedicated to understand their unique electronic optical mechanical and chemical properties however thermal and thermoelectric te properties of 2d materials remain largely underexplored despite their profound potential impact on one of the most important current scientific and technological challenges energy management thema is an ambitious project which aims to create a breakthrough in our understanding and ability to control phonon and energy transport at the nanoscale its main goal is to create novel 2d semiconductor nanomaterials and heterostructures for thermal management applications and te devices for power generation beyond current stateoftheart specifically by using phonon engineering approaches supported by advanced characterization the project targets the fabrication and onchip integration of a novel engineered transition metal dichalcogenide tmd based nanostructures for heat guiding and superior thermal insulation and b te power generators capable of recycling the waste heat from hot spots or environmental interlinks to deliver sufficient power to sustain lowpower electronics ultimate goal of the project is to provide innovative solutions for onchip energy management and energy harvesting for information and communication technologies the internet of things and 2d nanoelectronic devicesthe research proposed here will go beyond stateoftheart providing the indepth understanding of nanoscale energy dissipation and phonon transport in 2d nanomaterials and lay the foundations for the development of future threedimensional heterogeneous electronics the findings will drastically enhance the prospects of tmd materials for thermal management and te applications and boost their integration in the main semiconductor industry |
functional nanoscale therapeutics | we will develop new functional nanoscale medicines that engage and cooperate with cellular pathways that were designed to process and extract useful information from endogenous nanostructures as well as protect the organism from nanoscale pathogens we show how functional hybrid nanostructures partsynthetic and partcellderived biomolecular condensate elicit the full repertoire of cellular processing steps in particular the enabling of highly efficient escape from endosomes and providing intracellular access to nanostructure embedded biomolecular networks we show how cellular defences include nanoscale molecular interaction gating mechanisms that grant access on the formation of prescribed molecular assemblies that act as access key codes the assembled molecular interactions at these gates may be captured and analysed using timeresolved spatially localized chemical reactions within the cell and the enabling assemblies analysed in molecular detail the cellderived condensate portion of the hybrid particles may be reengineered to incorporate foreign proteins and rnas while retaining overall function and the new biomolecules can then be delivered to intracellular locations with their function intact these advances make it possible to understand the connection between nanostructure architecture and function and thereby open the pathway to recapitulate the functional nanostructures using purely preparative methods to apply these systems we first propose to use functional nanostructures to deliver specifically optimised mrna for covid19 spike protein into the cell optimising mrna metabolism to benefit from endogenous intracellular access we then propose to engineer and deliver cooperative networks of multiple mrna with the prospect of being able to develop functional nanoscale therapies that can counter more extended dysfunctional networks such as those found in the tumour microenvironment |
domestic forests and wood culture in the continental euroatlantic region 1300 1600 ce explaining change and redressing biased perspectives | woodlands in the continental euroatlantic region became heavily exploited from the late middle ages onwards the timber demand of growing cities and fleets promoted changes in oak quercus sp forestry practices and longdistance timber trade aiming to provide a fast and sustainable turnover of construction wood progressively changes in timberframed buildings and ship designs took place during the 15th and 16th centuries concurrently with shifts in woodworking techniques whether and how these changes and shifts in wood culture were interrelated is still a debated question dendrochronological datasets biased towards wood from old trees limited archaeological records and fragmented historiography have hampered thus far finding the answerwoodculture aims to explain changes on and redress biased perspectives about domestic forests timber supply building activity patterns and technological innovations in the continental euroatlantic region during the late middle ages and the renaissance c13001600 ce i will retrieve the currently missing wood archive of young and fastgrowing oaks from managed forests along with its associated historical technological and environmental context combining isotope dendrochronology archaeology and history with 3d scanning ai and gisthis groundbreaking interdisciplinary approach will provide a novel empiricallyfounded narrative about changes in woodlands and interdependencies between timber products construction designs and technological innovations in the continental euroatlantic region moreover it will reveal whether domestic forests became sustainable suppliers of construction timber at localregional scales putting the magnitude of timber trade into perspective the developed set of tools will revolutionise fields of study beyond material heritage history archaeology geography allowing the systematic analysis of hitherto unstudied timbers in historic buildings and archaeological sites |
correlates of protective immunitydriven investigation of malaria vaccine combination strategies | malaria remains a serious health concern worldwide with p falciparum considered one of the deadliest human parasites yet the currently approved vaccine against malaria rtssas01 offers limited protection due to challenges in vaccine development using current advances made in understanding immunity to address some of the existing challenges this proposal aims to develop a more efficacious vaccine against p falciparum by targeting multiple developmental stages sporozoite liver and bloodstage in this project combinations of 1 highly promising whole parasite vaccination approach targeting the liver latearresting gap 2 rtss provided by gsk and 3 mrna versions of clinically evaluated and partially protective blood stage vaccine candidates rh5 ama1dico sporozoite and blood stage will be evaluated in preclinical and smallscale human trials to discern the optimal combination for further clinical investigations to inform a rational design of future vaccine candidates captivate will analyse the vaccineinduced immune response to acquire a full understanding of malaria protective immunity and develop an advanced immunology insilico platform while immunity to blood stage malaria is relatively well understood the mechanisms of adaptive protective immunity for preerythrocytic malaria vaccine candidates are less wellestablished captivate addresses this critical knowledge gap by combining stateoftheart preclinical and clinical chmi in vivo malaria vaccine efficacy models with an innovative insilico platform comprising tcrvdj sequencing and artificial intelligence predictions to identify such mechanisms captivate assembles a unique combination of european experts in their respective fields malaria modelling in primates clinical vaccine testing insilico modelling of immune responses innovative omics approaches in an integrated interdisciplinary approach aimed at bringing the next generation malaria vaccines to the clinic |
environmental crimes intelligence and investigation protocol based on multiple data sources | the aim of the emeritus project is to realize and implement a protocol for effective environmental crime investigation leveraging on the integration of innovative monitoring and analysis technologies drones satellite data virtual sensors geointelligence data etc and on a complementary training programme aimed at fostering environmental enforcement authorities eg police authorities and border guards authorities intelligence and investigation capabilities at national and crossborder level in order to achieve this goal the emeritus consortium has gathered 8 policeborder guard authorities from 5 countries 4 security experts 2 training specialists and 6 technological partners that will be the core of the platformthe consortium will focus on the cocreation of an investigation protocol centered on environmental crimes investigation that will orient to the creation of the geointelligence platform this platform will integrate several monitoring and investigation technologies and data sources in a single view to support police authorities and decisionmakers secondly a new training programme for police authorities and other security practitioners focused on environmental wasterelated crimes investigation and prevention will be delivered combining both theoretical aspects and handon simulations to empower endusers to actually use the platform and related technologies such exercises will serve to validate both the platform and the protocol via simulations based on 4 realistic use cases heterogeneous and of growing complexity taking advantage of the shared will of police authorities and border guards to focus on ad hoc demonstration sites with the additional availability of partners simulation facilities the validation of the platform and of the protocol will result in the successful elaboration of a set of evidencebased recommendations for policy authorities and decisionmakers |
german romanticism a history of political ecology | studies in political ecology have demonstrated that our political concepts have been strongly influenced by our destructive relationship with nature generally endorsed they claim by the western philosophical tradition these studies are invaluable but lacking indeed they do not consider a politicalphilosophical tradition that criticised anthropocentrism the natureculture opposition and the submission of nature to human ends ie german romanticism 17941830 corroborated philosophical source of ecology hopes thesis is that the political thought of at least a part of the philosophers of german romanticism is consistent with the criticism against the destruction of nature by humans to them human beings freedom does not imply the exploitation of nature and they claim that some political institutions better foster a harmonic relationship with it can we consider german romanticism as a phase of a yet to be written history of political ecology the historicalphilosophical perspective offered by this project is urgent the increasing importance of the environment in politics demands a reexamination of our political concepts and history of political philosophy offers new viewpoints coming from old insightshope is divided in two phases 1 in the first it focuses on alexander von humboldt the romantic author who reflected the longest on the relationship between politics and nature 2 in the second the political thought of other keyfigures of german romanticism are investigated the methodology of hope is conceptual history its use to address topics related to ecology will fill a gap in literaturehope will be hosted at enspsl and depaul university four research articles will be published a workshop and a conference will be organised a website will be created hopes communication and dissemination strategy will improve awareness on environmental issues and give relevance to women philosophers less known than their male counterpart |
sustaincell durable and sustainable component supply chain for high performance fuel cells and electrolysers | the sustaincell project aims at supporting the european industry in the development of the next generation electrolyser and fuel cell technologies both low and high temperature by developing a sustainable european supply chain of materials components and cells significantly less reliant on critical raw materials crm with lower environmental footprint and costs and higher performance and durability than existing technologies this will rely on scientific breakthrough innovations with the development of ecodesign guidelines and environmentally friendly manufacturing routes applied for the production of new crmlean andor crmfree materials and architectures designed for maximising functionalities and durability while decreasing crm content per unit cell the new flexible and scalable processing routes will exhibit higher productivity as well as reduced utilities consumption and greenhouse gas emissions the development of enhanced recovery and treatment processes for optimising both recovery and reuse of pgmscrms and ionomers extracted from endoflife stacks and production processes will furthermore reduce the reliance on import of materials the novel solutions will be validated at cell level for all technologies using harmonized testing procedures this ambitious work will be supported by the development and implementation life cycle thinking tools addressing environmental and economic dimensions to drive the research and development work using quantifiable sustainability criteria the project is led by sintef and gathers cea cnrs vtt forschungszentrum juelich tecnalia dtu dlr epfl and hesso world leading experts in the value chain of alkaline proton exchange membrane anion exchange membrane solid oxide ion conducting and proton ceramic conducting electrolysers and fuel cells the open innovation research will be actively communicated to european academia and industry to exploit the results of sustaincell for the benefits of the society |
spiking photonicelectronic ic for quick and efficient processing | rapid advances in artificial intelligence technologies have led to powerful models and algorithms that have revolutionized many applications across all fields of science and technology deep learning performed within artificial neural networks has yielded new ways to process data leading to sophisticated systems with impressive functionality and benefits however conventional computing hardware is reaching its limits in terms of energy efficiency and speed a new approach to computing hardware is needed novel braininspired or neuromorphic chips working with biologicallyinspired spiking neural networks have gained attention as they promise highly efficient ways to process data important research effort has been dedicated to develop such neuromorphic systems in electronic or photonic hardware separately each with its drawbacks and limitations spikepro proposes a sciencetowardstechnology breakthrough by combining lowenergy electrical and photonic neurons into a joint spiking neural network on an integrated circuit spikepros chip integration approach is based on a common technology platform connecting ultrafast laser optical neurons with efficient electrical spiking diodes through nonvolatile synaptic weights this enables to simultaneously capitalise on the advantages of both electronics and photonics to deliver efficient and highspeed snns going beyond existing implementations in addition to reducing the energy consumption per spike in the network spikepro will also develop novel learning strategies and algorithms able to work with reduced number of synaptic connections these will be possible by exploiting the hardware parameters of the electrical and photonic spiking devices the outcome of spikepro will have lasting economic societal and scientific impact the project will bring ultrafast and efficient neuromorphic hardware into the disparate fields of edge computing sensor data processing highspeed control and computational neuroscience |
urban waste and water treatment emission reduction by utilizing co2 for the production of formate derived chemicals | the waterproof project proposes a resource efficient solution convert co2 emissions from wastewater processing into green consumer products at the heart of the waterproof concept is an electrochemical process that converts co2 originating from waste incineration and wastewater processing to produce formic acid this reaction is paired with the generation of highenergy oxidants which are used to remove persistent contaminants from wastewater thereby contributing to a clean water cycle with zerowaste the energy to run the electrochemical process is provided by waste incineration facility the formic acid is a feedstock for the production of acidic deep eutectic solvents ades these ades are used to extract precious metals from water treatment sludge and incinerator ash additionally the formic acid is used for fish leather tanning to sustainably produce fish leather and will be tested in consumer cleaning products the waterproof technology results in a ghg reduction based on co2 utilization replacement of fossil feedstock and by industrial electrification in the waterproof project a trl 6 plant is constructed including innovative downstream processing the conversion of co2 from wastewater treatment and the co2 captured at a waste incinerator is demonstrated in two consecutive campaigns to maximize impact of the waterproof technology lifecycle assessments and a full business case analysis are initiated in the early stage of the project to provide targets for technology development a marketing and deployment strategy is developed to ensure social acceptance of the waterproof technology besides the reduction of ghg emissions waterproof will have societal impact by creating awareness trough interaction with policy makers and civil society and the creation of new jobs in innovative fields by targeting an industry as essential as wastewater treatment waterproof aims to create a concept that can impact society and climate on a big scale |
demonstration of battery metals recovery from primary and secondary resources through a sustainable processing methodology | the european union has underexploited potential to produce critical raw materials crm and special metals as stated in the study on the eus list of critical raw materials 2020 concretely the battery sector is considered as a key strategic sector for the eu due to the increased use of batteries in different important sectors such as electric mobility thus metallico proposal presents a new opportunity for the european union it is composed by an strategic consortium along the value chain including mining and industrial sites with primary and secondary sources of critical and battery metals li co cu mn ni experienced partners to pilot novel processes for producing batterygrade materials based on previous projects and activities industrial and sme endusers in the battery cement paint and ceramic sectors and partners to demonstrate the sociallicensetooperate including the support of government bodies sustainability and commercial chances that the solution represents worldwide these battery metals are predominantly in chile australia south africa china and the democratic republic of congo representing a high risk for the eu in terms of supply shortage for example in the case of li the eu import reliance is 87 for lithium concentrates and 100 for refined compounds as there is no domestic refining metallico includes 4 cases studies in the eu to recover batterygrade li2co3 from a primary spodumenelepidolitepetalite deposit co concentrates and batterygrade coso4 from a mine secondary resource clc and cu co mn and ni concentrates from metallurgical slag from a pb refining company khgm and secondary mine tailings tharsis upscaling of sustainable and innovative upstream and downstream processes will demonstrate the technoeconomic recovery and production of these critical and important metals for the eu |
unravelling extracellular vesicle heterogeneity to inspire improved therapeutic rna delivery systems | the growing number of classes of rna therapeutics including sirna mrna and rna components of the crisprcas9 machinery hold the promise of providing new treatment possibilities for almost any disease however these interventions require delivery of therapeutic rna to their final intracellular targets in diseased cells and delivery efficiency by current rna nanocarriers is unsatisfactory endogenous nanoparticles called extracellular vesicles evs have emerged as promising novel rna delivery systems due to their intrinsic ability to transfer biological cargo between cells in a selective manner in fact with my erc stg i have shown that evs outperform synthetic carriers in terms of rna delivery efficiency however evs are a heterogeneous population of vesicles that differ in their targeting and cargo delivery properties which forms a hurdle for the design of evbased delivery systems as methods to separate ev subpopulations and study their characteristics individually are lacking a fundamentally different approach to address this hurdle is necessarythe aim of unravel is to reveal how variations in ev composition lead to specialized subpopulations with unique delivery features using this knowledge i will develop the first biomimetic class of evinspired synthetic rna delivery systems i will pursue three objectives1 identify ev subpopulations with unique targeting and rna delivery properties using a novel ev barcoding strategy2 define these ev subpopulations in terms of unique surface properties intracellular trafficking and cargo release3 apply this knowledge to improve synthetic rna delivery systems by incorporating molecular features from ev subpopulationsthis work will significantly advance our understanding of the natural targeting and rna delivery mechanisms of ev subpopulations and may result in a new generation rna delivery system based on ev mimetics in turn this will allow more widespread application of rna therapeutics |
bio massderived microsupercapacitors for iot devices | the increasing importance of the internet of things iot for applications within eg climate monitoring for agriculture water quality measurements or industrial process control drives the development of compact microelectronic systems for portable wireless sensors in consequence the demand for miniaturised energy storage systems is growing rapidlyin our ercfunded research we have invented a novel method for fabrication of biomassderived 3d electrodes for electrochemical energy storage with custommade dimensions and shape within biomicap our objective is to transition from laboratoryscale single electrode studies with aqueous electrolytes into a commercially relevant encapsulated microsupercapacitor sc device with thermally stable electrolytes compared to existing sc our electrodes are binderfree without metal current collector and recyclable the use of additive manufacturing technology allows for the fabrication of custommade miniaturized energy storage devices for specific iot applicationswe will validate the biomassderived sc as a sustainable and green power source for iot devices through field tests in collaboration with our industrial partners the innovation process includes an analysis of commercial feasibility a followup on the existing ip strategy and the development of a business strategy that enables the commercial exploitation of the sc by a spinoff company |
open 2d quantum simulator | open2qs aims to deliver a disruptive change in our capabilities of analog quantum simulation of open 2d manybody systems for the first time this will allow us to investigate quantum matter with competing coherent and dissipative processes over extremely long times a regime that is inaccessible by current technology this will open a new window for the discovery of emergent dynamical phenomena and states of matter such as quantum glasses as any system in nature eventually couples to an environment and thus is open the research program of open2qs will deliver foundations and concepts whose relevance extends to chemistry biology and information processing thereby also forming a basis of future technological innovationopen2qs ambition to redefine the stateoftheart of open system quantum simulation will be achieved by employing ion crystals forming twodimensional geometries which host 100 individually addressable and mutually coupled particles strong statedependent tunable dipolar rydberg interactions will allow for a full control over the buildup of quantum correlations in 2d geometries vibrational phonon quantum degrees of freedom will enable the engineering of irreversible dissipative processes the ensuing complex dissipative dynamics will be stabilized over thousands of dissipation cycles via coherencepreserving insitu optical cooling monitoring quantum trajectories under dissipative dynamics and an unprecedented access to reservoir correlation functions will enable the investigation of collective relaxation behavior and exotic forms of matter we will study the impact of quantum effects on phase transitions explore correlated dynamics in quantum glasses test fundamental principles of quantum thermodynamics and advance numerical algorithms through a close theoryexperiment interplay to achieve these goals we have gathered a worldwide unique team of pioneers in trapped ions rydberg physics and quantum nonequilibrium theory |
torsional atomic force microscopy to optimize the fabrication processes of organic electronic devices | organic semiconductors have become promising materials for the design of electronic devices since they are light flexible low cost and feasible for large scale manufacturing the efficiency of an organic device has a strong dependency on the selected organic molecule and its organization in the electronic device fabrication processes with standard organic molecules currently produce thin films consisting of a large number of crystalline domains without control of their orientation nor of the locations of the originated grain boundaries grain boundaries can act as charge traps and electron scattering centers resulting in a reduction of the electron mobility within the film therefore there are big differences in the electronic properties from one device to another device even if they are fabricated under the same conditions thus a major effort within organic electronics is devoted to refining the fabrication processes leading to uniform and controlled electronic properties of the devices in this proposal it is planned that i develop a novel atomic force microscopy afm technique based on torsional eigenmodes capable of detecting fast and in a precise manner the crystalline domains of anisotropic organic layers utilized in organic devices i will receive training in the fabrication processes of organic thin films by the host group and i will look for fabrication strategies to optimize the organic film deposition that enhances the electronic performance of organic devices the developed afm technique will be applied to study the domain distribution of the fabricated organic samplesthis action is expected to have a relevant impact in the organic electronic field enhancing the characterization and fabrication methods for organic device production that lead to an increase in energy efficiency likewise this action will impact my career enabling the transition into a position as an independent researcher |
the microfoundations of macroinstitutions an empirical investigation of the coevolution of populist rhetoric and organizations | micropopulism aims at providing an indepth analysis of the microfoundations of populism in order to gain a granular understanding of populist rhetoric that can undermine european values as well as the drivers of this rhetoric and its economic consequences management scholars have made progress in understanding the coevolution of organizations and institutions their contributions only peripherally touch upon macroinstitutions and ignore the rhetoric element of institutional change i want to fill this gap and provide a better understanding of how organizations construct macroinstitutions and to conflate coevolution theory and discourse analysis this research project takes plays in the context of populism and multinational enterprises mnes mnes are powerful organizations that shape globalization forces and economic developments populism defines political institutions and contains a central rhetoric element as populists frame the political debate i will delve into discourse analysis and the rhetoric of populists to accommodate the varieties of their ideas the analysis of speeches press releases or social media posts of populists should enlarge the comprehension of the microfoundations of macroinstitutions and allow for an integration of discourse into coevolution theory i will also draw on hierarchicallinear modelling to explore the coevolutionary causalities between organizations and macroinstitutions micropopulism will last 24 months and will be conducted at luiss guido carli italy under the supervision of prof antonio majocchi an expert in institutions mnes and economic performance luiss focuses on political science and management studies and is an ideal institution for accommodating the interdisciplinary nature of this research project results of this project are relevant for different societal groups and will thus be disseminated and communicated to the academic community policy makers industry and general public |
unlocking the potential of aibased weather forecasts for operational benefits | kairos will improve the quality of meteorological information provided to the aviation community through the use of artificial intelligence by producing accurate digital weather forecasts at longer lead times aviation stakeholders will be bettered position to mitigate the impacts of weather on their operations kairos will mature the trl of results from previous sesar exploratory research projects with the goal of reaching trl 7 through the completion of operational demonstrations the project will integrate live weather information from ai forecasts with existing decision support tools and platforms to assess the operational benefits to several endusers the kairos solution will enable a paradigm shift in the management of demand capacity balancing at all levels of the european airspace system including network level local fmp and uam kairos aibased weather forecasts are intended to be an enabling technology that will unlock operational efficiencies and the automation of planning activities within the airspace system by providing accurate weather forecasts earlier in the air traffic flow management process aviation stakeholders including ansps airports and airlines will be able to formulate strategies to minimize the disruption to their operations |
linking soil biodiversity and ecosystem functions and services in different land uses from the identification of drivers pressures and climate change resilience to their economic valuation | the main objective of bioservices is to understand the interconnection between soil organisms virus bacteria archaea fungi protists nematodes microarthropods earthworms isopods millipedes insects and spiders and the delivery of multiple soil ecosystem functions and services at different scales field vs landscape identifying the pressures and drivers resulting from different land uses and climate change and performing an economic valuation of the contribution of soil organisms to ecosystem services bioservices will also deepen in the relationship between soil organisms and soil structure and how this interaction is affected by land use and management intensity to contribute to the soil mission objective 6 improve soil structure to enhance habitat quality for soil biota and crops bioservises will thus deliver new knowledge new indicators based on soil organisms and the ecosystem functions and services in which they are involved and digital decisionsupport tools and models to help design climate resilient management practices and monitoringconservationrestoration programmes adapted to a range of environments land uses and biogeographic regions across europe to maintain and foster the multiple soil ecosystem functions and services in which soil organisms are involved it will also give relevance to soil health and soil ecosystem functions and services delivered by soil organisms in the update of eu and national legislations for this bioservices is using experimental sites across 8 land uses and 5 biogeographic regions from europe as central hubs for cocreation and codesign multiactor approach responsible research and innovation rri and open science |
european infrastructure for rydberg quantum computing | euryqa aims at establishing rydberg quantum processors as a leading platform for scalable quantum computing rydberg atoms have already provided proofofprinciple demonstrations of all the requirements for general purpose digital quantum computing and are today the only platform that has demonstrated more than 200 qubits with strong interactions and with a clear path to further scalability and eventually fault tolerant operation to develop the next generation of fully programmable and scalable quantum computing systems based on rydberg atoms and open them up for the european community now requires a coordinated interdisciplinary and intersectoral effort for this the euryqa consortium combines partners from academia and the private sector that are at the forefront of coldatom technology with key industrial partners with complementary expertise on quantum hardware classical electronics firmware and software the project will bring together four rydberg platforms with 1001000 qubits including three nationally funded platforms and one leading european start up to provide a unique european solution to rydbergbased quantum computers together with europewide benchmarking and standardization of the technology we will provide a common quantum computing stack for rydberg atoms a federated cloud service solutions to concrete computational problems leading to a quantum advantage and key technology and a blueprint for faulttolerant quantum computing with rydberg qubits |
machine learningbased prediction and evaluation of supercapacitor performance of transition metal carbide developed by using waste surgical masks during covid19 | fossilfree and renewable energy sources are a must for a sustainable society pushing the limitation of supercapacitors sc beyond their limits by producing metal carbides using as carbon source spent surgical masks an immense sideproduct burden of covid19 pandemic mestum project aims to tackle the worldwide increasing energy demand with highly efficient stable environmentally friendly and lowcost electrode materials em the development of em by transition metal carbides has attracted significant research attention thanks to its hightemperature stability conductivity easy operation in aqueousorganic electrolytes and insignificant electrolyte leaching easily accessible and abundant manganese metal carbides with multiple electron transfer ability represent an excellent source possessing the key performance markers for sc groundbreaking pseudocapacitance and cyclic stability by exploring the challenge of also generating a porous structure mestum aims to expand an electrochemically active specific surface area and porosity of transition metal carbide and thus deliver a significant growth of specific capacity performance during synthesis the groundbreaking approach of turning the porous carbon from the surgical mask into the transition metal structure will orchestrate a brilliant coupling of increasing the surface area and reducing surgical mask waste for machine learning prediction of specific capacity and cyclic stability the two most critical performancerelated features of sc the materials properties morphology composition surface area etc and operational conditions electrolytes current density potential window etc are crucial to tackle this issue the project will set the optimized parameters to easily evaluate the prospects of developed materials in sc application by a pioneering effort toward the significant advancement of sc technologies the mestum project will address a fundamental need for clean energy sources |
sculpting circuits and behavior by developmental neuronal remodeling | neuronal remodeling is a conserved strategy to refine neural circuits during development defects in remodeling have been associated with neuropsychiatric disorders but direct mechanistic causality is lacking despite its fundamental significance how remodeling of neuronal processes affects circuit architecture and function and how this ultimately shapes behavior is not only unknown but also extremely challenging to study in complex organisms our lab is a worldleader in the molecular mechanisms of neuronal remodeling we use the stereotypic remodeling of the drosophila mushroom body mb a complex circuit within the fly brain as powerful genetic model to study this question recently we uncovered that mb remodeling is coordinated at the circuit level furthermore we generated a detailed expression atlas of mb neurons during development which highlighted genes and pathways mediating cellcell interactions as prime remodeling regulators thus our discoveries suggest that the time is ripe to take on the challenge of integrating the molecular cellular circuit and behavioral aspects of remodeling the mb is a perfect system for this due to its wellcharacterized structure and function to accomplish this goal we will build upon our developmental expression atlas to identify molecules that mediate cellcell interactions during remodeling obj 1 we will then investigate how specific geneticcellular perturbations of remodeling impact overall circuit architecture and connectivity obj 2 finally taking a new direction for the lab we will use behavioral readouts of mb function to understand how specific genetic perturbations of remodeling and connectivity affect circuit function and behavior obj 3 while each objective is independent and expected to yield highimpact discoveries by itself it is their combined implementation that is expected to provide the first holistic picture of neuronal remodeling from molecules to cells circuits and function |
medical integrated photonic ultrasound transducer | the multisensing medical integrated photonic ultrasound transducer mediput project will develop a highresolution highquality recyclable medical imaging system based on a disruptive integrated photonic ultrasound transducer concept we envisioned a 100x increase in sensitivity compared to conventional usthe iputbased sensing system combines optical waveguides and micromechanical membranes with two optical readout techniques rr and mzi to at least two us applications medical ultrasound us and photoacoustics pa we will solve technical challenges such as increasing sensitivity mass parallelization by optical multiplexing and hybrid integration of microelectronics in pic tuneable waveguides fiber chip coupling manufacturability and packaging these advances will lead to a higher production yield and increased insight in the processing solutions of hybrid integrated photonics the iputs are based on easily accessible materials dont require lead to improve the performance and laser power can be reduced significantly we will iteratively develop an effective soi and sin manufacturing process to realize very sensitive iput sensors and integrate them into us transducer arrays for medical imaging and pa for validation and demonstration on phantoms instead of tissue the partners have the inhouse capability to develop manufacture integrate and package the novel iputbased sensing systems into transducers covering the full manufacturing value chain the increase in sensitivity will enable 1 an increase of the us image by a factor 22 an increase of the penetration depth by a factor 23 a 100x reduction of the peak pressures4 a 100x reduction of the required laser power for pa resulting in the use of lowcost lasersmediput reinforces european industrial leadership in highperformance multisensing system development and manufacturing particularly in the healthcare sector |
dynamicc collaboration to generalize ecofriendly trajectories | concerto aims to provide the means to maximize the opportunities for co2 reduction and to introduce nonco2 impact management in daily operations the goal is to reach trl6 processes and tools that allow the ecosystem to achieve more ecofriendly trajectories and thus higher climate impact reduction without requiring major changes on legacy atm and airlines systems to do so two specific objectives are declined for concerto the first one focuses on co2 emissions reduction when the second one introduces nonco2 climate impact reduction mitigation means finally as concerto is a data driven project generating data on co2 and nonco2 effects and opportunities at tma atsu and possibly network level the project presents the opportunity to contribute to the improvement of european environmental performances dashboardsambition 1 keep the pace on co2 emissions reduction integrate green atc capacity in atm processes with the appropriate level of automation and support atm actors in balancing permanently regularity and environmental performance at local and network level ambition 2 by leveraging stateoftheart climate science allow atm actors to take their ecoresponsibility to the next level ambition 3 strengthen cooperation anticipation and exchange of information between nm air traffic control airlines and flight planning service providers ambition 4 demonstrate that mitigation measures such as the ecofriendly orchestrator and echo area avoidance concepts can be deployed progressively at network level in close connection with scientific progress |
the silent phase of alzheimers disease from brain states to homeostatic failures | neuronal circuits must balance stability and plasticity how this balance is compromised in brain disorders remains one of the most fundamental questions in neuroscience pioneering studies in the field established that homeostatic mechanisms stabilize the function of a system at a setpoint level of activity recently we have identified bona fide mitochondrial regulator of activity set points and provided support to our standing hypothesis that homeostatic failures destabilize network activity in alzheimers disease ad however we have just scratched the surface of the mechanisms stabilizing activity set points in vivo i propose a conceptual and experimental framework to identify the cellularmolecular and circuitwide in vivo mechanisms underlying stability of hippocampal circuits across distinct brain states and stabilityplasticity balance using a wide range of optical electrophysiological computational and molecular tools we will explore homeostatic regulation of activity in hippocampal circuitry a crucial substrate for memory formation and its relation to ad first we will establish governing principles of homeostatic regulation in physiological context of sleep and learning next we will explore the underlying molecular drivers of homeostatic regulation finally we will test the causal relationship between dyshomeostasis of activity in hippocampal circuits sleep disturbances and cognitive decline in ad models to target these questions we will utilize the basic concepts of control theory and an integrative approach which spans brainstate neural circuit synaptic and molecular levels we believe that this understanding is an essential step to uncover the principle basis underlying the transition from a presymptomatic disease stage to clinically evident cognitive ad impairments the proposed research will elucidate fundamental principles of neuronal function and reveal conceptually novel insights into how to maintain ad in a dormant state |
innovative value chains for european ceramic oxide fibres | oxide fibre reinforced ceramics socalled oxide ceramic matrix composites ocmc have to be considered as strategic materials from now to the future eg for use in next generation aeroengines stationary gas turbines powertox processes with concentrated solar power csp chemical industry batch carrier for high temperature processes etc today such highend ocmc components and the key raw material the ceramic fibres as reinforcement component are mainly exclusively produced in the united states but as these are key components for the european manufacturing energy and aerospace industry there is a need to develop a european oxide fibre and ocmc component industry decreasing dependence on noneu producersthe invecof project addresses this need and provides a substantial contribution to sustainable product innovation action through the two following key activities1to develop a european oxide ceramic reinforcing fibre equivalent to us fibres and to establish it among end users rof fibre and 2to develop and validate a nextgeneration fibre in parallel with improved thermosmechanical properties ngo fibre the rof fibre will present an equivalent to the dominant 3m nextel fibres with better availability without dualuse restrictions from the us and possibly lower price is needed and the ngo fibre will have improved thermomechanical properties compared to the benchmark fibres in order to make processes plants turbines etc more energy efficient through higher application temperaturesthe project invecof innovative value chains for european ceramic oxide fibres covers the whole process chain beginning from fibre development and production over weaving these fibres to fabrics to ocmc manufacturing coupons and demonstrators for every enduser application up to testing oxfibers and ocmc components in relevant environments with project partners for every step from three countries in europe |
building on the achievements of plan s to further advance open access and scholarly communication | the european commission has made great strides in pushing for a more open scholarly publishing system in the past 15 years and open access to publications is now mainstreamed into the european commission research funding framework the ec has been supporting a consortium of research funders called coalition s that have adopted an open access mandate for recipients of their funding called plan s which required coalition s grantees to publish all peerreviewed articles resulting from their grant funds in open access oa in the five years since plan s was published coalition s has grown from 12 founding members to 28 and the plan s principles have been implemented in the participating funders policies we are now in a position to evaluate the first five years of plan s and coalition s and reflect on lessons learned and the road aheadthe oaadvance project will contribute to strengthening coalition s as an instrument to advance the european commissions and participating funders shared vision to deliver full and immediate oa it will work to achieve this by assessing the impact of plan s through an independent review and by providing recommendations on how to build on the achievements of plan s to support a new vision for the future of scholarly publishing |
science communication through immersive media arts an innovative framework for artsbased science communication | science communication sc is more important than ever the recent covid19 pandemic demanded public accountability clear discussion and the ability to disagree in public sc may be essentially defined as the social appropriation of science and technology enhanced by the integration of science with other beliefs therefore if science can inspire art can art inspire interest and learning about science in its turn how can we make use of artistic expression driven by emerging technology such as 360degree video virtual reality augmented reality or mixed reality as to create innovative and effective artsbased science narratives in spite of the growing proliferation of collaborative artistic exhibitions performances and installations that aim to activate science schwartz 2014 it is still unclear whether artsbased science communication absc is distinctively effective in raising awareness or shaping public policy most absc projects fail to articulate information about project goals and few projects disseminate performance assessments lesen et al 2016 thus this research project is focused on obtaining a systematic understanding of the main objectives challenges and outcomes surrounding absc and whether and in what ways these projects set and meet goals as well as what steps can be taken to foster best practices by developing conducting and critically reflecting upon a series of immersive media absc experiments involving scientists immersive media artists and the general public the ultimate goal is to obtain an innovative framework with guidelines and best practices for future immersive media and other artsscience collaborative projects while further conceptualizing the field of artsscience collaborations and generating substantial impact on society |
entering the deep quantum regimes of nonequilibrium thermodynamics | can we extend nonequilibrium thermodynamics to probe complex quantum phenomena in the 90s the scope of thermodynamics broadened to include small systems and farfromequilibrium transformations building on these advances the emerging field of quantum thermodynamics has recently lead to breakthroughs formulating nonequilibrium thermodynamics in the quantum regime motivations range from the search of quantum advantages in heat engines or quantum batteries to the expression of global constraints on manybody quantum dynamics stemming from the second law however deep quantum regimes where largest deviations from classical thermodynamics are expected remain elusive limiting applications at weak systemreservoir coupling a finer description of the coherentdissipative regime is lacking to evaluate the resource costs of quantum control optimize quantum heat engines or understand the energy transfers during a quantum measurement this in turn hinders experimental developments of quantum thermodynamics in more platforms to express fundamental nonequilibrium bounds on the energy exchanges with quantum materials and use thermodynamics to probe manybody dynamics new coarsegrained description are crucially neededproject qarnot will address those timely issues owing to a novel strategy combining cuttingedge methods from quantum open system theory beyond the most common approximations with newlyderived universal thermodynamic descriptions of quantum systems to bridge the gap between quantum thermodynamic laws and experimentally or theoretically accessible physical variablesby unlocking the deep quantum regimes of nonequilibrium thermodynamics qarnot will provide a new versatile analytical toolbox to probe quantum manybody and dissipative dynamics notably qarnots advances will be employed to solve the important bottleneck of the thermodynamic description of realistic quantum measurement and enable a broad experimental use of thermodynamic concepts |
mott insulator transition in a quantum fluid of light | photons are great carriers of information but they usually dont interact with one another atoms interact but are hard to manipulate and do not benefit from the toolbox of quantum optics for detecting quantum fluctuations and entanglementmany approaches have been proposed to marry these two systems for quantum simulation of condensed matter with strongly interacting photons but to date the realization of largescale synthetic materials made of optical photons is still missingmy project targets this exciting goal namely the creation of synthetic photonic matter it relies on the original approach of engineering a quantum phase transition in a fluid of lightspecifically i will investigate the superfluid to mott insulator transition for light propagating in a dense cold atomic cloud photons will acquire an effective mass due to the paraxial approximation and i will generate and tune the strong photonphoton interactions via a giant kerr nonlinearity induced by manipulating atomic coherences in this regime photons will behave as a quantum fluid of light and follow an evolution similar to ultracold atomic quantum gasesmy original hypothesis is that a fluid of light should undergo the same phase transition driven by quantum fluctuations as quantum gases do and that a manybody state of light will emerge from this transitionat the fundamental level a mott insulator state of light allows for exploring truly quantum effects such as the emergence of analogue of phase transition in nonequilibrium systems the presence of quantum depletion and prethermal states and the entanglement dynamics in manybody systemson the applied side a photonic mott insulator is a giant source of single photons or any fock state with potentially several hundreds of lattice sites delivering tunable photon numberstates in parallel it will be a game changer for scalability issues in photonics quantum technologies |
wireless stentlike soft millirobots stentbot for minimally invasive brain vasculature disease treatments | diseases in the brain vasculature such as acute ischemic stroke aneurysm and brain tumors are fatal and require medical devices to treat them with minimal invasion however current tethered devices have limited safe access into the distal or tortuous vascular routes which prevent saving lives of some patients therefore we propose a wireless stentshaped magnetic soft millirobot stentbot which would have the capability of safe access to such routes also the stentbot will be able to be repositioned afterwards without repeating the same procedure fully again if the disease location changes or if the initial position of the device is observed to be not optimal such robot concept was originated in the ercadg project of the pi after reaching its target location safely and precisely under medical imaging and external magnetic actuation guidance the robot will deliver the tissue plasminogen activator drugs ondemand locally to treat the acute ischemic stroke moreover the robot will be used to treat aneurysms minimally invasively by becoming a flow diverter to regulate flow into the aneurysm sites |
digitalization of public service delivery and inclusive development | an estimated 57 million people die every year and another 100 million are pushed into extreme poverty due to limited access to essential public services in lowincome countries lancet health commission 2018 governments across the globe have responded by adopting digital technologies eg by making services available to citizens virtually in the hopes of providing broader faster and cheaper access to public services while highincome countries have made impressive strides in this regard lowincome countries continue to struggle with nearly onethird of digitalization projects being abandoned and substantial resources being wasted world development report 2016 moreover even when successful these digitization projects they risk excluding vulnerable individuals with limited connectivity potentially widening existing inequalitiesthis research proposal aims to advance our understanding of i the determinants of the success or failure of digitalization in the public sector of developing countries and ii the ways digital technologies can be harnessed to improve the efficiency and inclusion of public service delivery thereby producing more robust and inclusive economic growth in collaboration with local governments and ngos i will design and carry out four largescale randomized experiments in countries where public services are being digitized india indonesia sierra leone liberia in these experiments i will study digital technologies that influence i the demand for public services by allowing citizens to access them digitally and ii the supply of inperson services by remotely monitoring or supervising the delivery agents the results will inform public policy in lowincome countries ultimately helping a broader segment of the population access more and higher quality public services |
hidden states and currents in biological systems | the ability to infer information about hidden degrees of freedom from time series would revolutionize experiments on single molecules mesoscale assemblies and tissues as well as financial and climate systems hidden dynamics are often essential as they reflect the approaching of a critical transition or describe its mechanism eg the folding of a protein or rna or an abrupt shift in climate with the project proposed here i plan to push our quantitative understanding of experiments ranging from singlemolecule spectroscopy to observations of migrating cells and developing tissues to a new level by exploiting how the properties of a highdimensional landscape and current imprint onto the time ordering of projected states along individual trajectories i will introduce functionals of projected paths that are easily inferred from data and analyze their statistics and measure concentration by combining the theory of functionals of stochastic paths concentration inequalities and semiclassical analysis and apply these to singlemolecule force spectroscopy and plasmon ruler experiments cell tracking and molecular dynamics simulations a distinctive characteristic of the project is the focus on nonasymptotic measure concentration ie on occurs with high probability results that will be addressed for the first time in the context of nonequilibrium physics providing a new framework for interpreting experimentsusing the information readily encoded in the data but inaccessible to existing approachesthe project will generate new knowledge that will resolve the longstanding debate about intermediates in dna rna and protein folding controversies about non converging dynamics of folded proteins and shed new light on the operation of nanomachines and selfassembly far from equilibrium as well as cell movements during tissue regeneration it will lead to a paradigmshift in soft matter and biophysics and may reshape actuarial and climate science |
energyefficient hardware implementation of memristorbased inmemory computing | neuromorphic engineering is an emerging bioinspired discipline that morphs the biological brain on custom silicon although memristors rose as a potential synapse to solve the density challenge in a memristive crossbar the scalability of the crossbar is limited by its power dissipation and chip area to contribute to low power dissipation i focus on improving the energy efficiency of the synapses nonfilamentary category and neurons which are the fundamental constituents of the neural networkenabled iots the energy efficiency of the synapses will be improved by applying fast switching pulses on the bulkbased synapses that result in low switching currents the energy efficiency of the neurons will be improved by taking advantage of the fdsoi28nm technology node by which the neurons are designed a dedicated pcb will be designed assembled and mounted that house both the synapses and the neurons which will be energyefficiently used to recognize digits or letters by unsupervised learning rule |
towards cancer patient empowerment for optimal use of antithrombotic therapy at the end of life | despite the fact that antithrombotic therapy att has little or even negative effects on the wellbeing of cancer patients during their last year of life stopping att is rare in clinical practice in contrast att is often continued until death resulting in excess bleeding higher healthcare costs and increased disease burden serenity will develop an informationdriven palliative care shared decisionmaking process enabled by a userfriendly easily accessible webbased shared decision support tool sdst that will facilitate treatment decisions regarding appropriate use of att in cancer patients at the end of life serenity will use a comprehensive approach consisting of a combination of realist review flash mob research three epidemiologic studies in nl uk and dk and qualitative interviews the results of these studies will be used in a delphi process to reach consensus on the optimal design of the intervention using the consensus reached in the delphi process the sdst will be designed to be patientspecific with adaption to gender cancerrelated cultural and socioeconomic factors proceeding the sdst will be tested and optimised in a randomised clinical trial a targeted implementation and exploitation plan will be developed to enable the use of the serenity approach across europe as well as incorporation in national and paneuropean clinical guidelines and policies the intervention will ultimately lead to appropriate use of att prevention of bleeding complications and considerable cost savings in addition to improved quality of life and treatment satisfaction of patients their carers and involved healthcare professionals the intervention will empower cancer patients and their carers enabling them to make their own choices the intervention will reduce the disease burden of hundreds of thousands of people living with cancer receiving palliative care each year throughout all eu regions |
prevention of radiotherapy and chemotherapy induced oromucosal wounds using an oral application gel murnia mouth gel | cancer is a devastating and costly condition expected to increase significantly by 2030 according to the 2018 who report the global cancer burden is estimated at 181 million new cases annually mucositis is a condition in cancer patients that manifests as severe ulcerations in the mouth and the gastrointestinal tract oral mucositis om is cancer treatments most significant side effect worldwide mucositis can be caused by chemotherapy andor radiotherapy it occurs in nearly 40 of patients receiving conventional ct 80 receiving highdose ct as conditioning for haematopoietic stem cell transplantation and 100 receiving hn radiation therapy with 65 of those progressing to severe grade levels with significant adverse outcomesthe problem with om is that while current therapies are focussed on dealing with its symptoms like inability to eat or significant pain there is no real cure or prevention for om itself existing products in the market for om mainly offer symptom management focusing on pain or at best duration reduction claims the one approved drug for chemotherapy and radiotherapy amifostine has severe side effects and tumour protective properties making it hard to use as it interferes with the actual cancer treatment kepivance which is only approved for haematological malignancies is challenging to administer posing compliance issues and does not solve the more significant need for solid tumoursumayana has developed a proprietary preventative and curative formulation to combat om in cancer patients global patent wo2020072987 usa patent 11331360 b2 |
sustainable and costefficient concepts enabling green power production from supercriticalsuperhot geothermal wells compass | the compass project is inspired by global efforts to improve utilization of geothermal resources by enlarging production fields downwards energy output can be enhanced without the need to expand surface infrastructure by drilling into deep and hot formations calculations indicate that wells drilled into superhot conditions will yield 510 times more than a conventional well which can significantly reduce number of wells required the main challenges to achieve this are related to the well integrity due to extreme temperature changes and corrosive fluid chemistry encountered two of three wells in the iceland deep drilling project iddp have already been drilled and had serious problems with casing failures numerous examples of casing failures in conventional geothermal wells show that current well concepts mainly transferred from oil and gas applications are barely sufficient for geothermal use compass will address these challenges by developing improved and innovative well casing technologies to mitigate casing failures novel foam cement solutions will be developed suitable for high temperature formations this system would work with available flexible couplings to mitigate hightemperature induced stresses and ensuring well integrity costeffective lasercladding will be used to improve corrosion protection inside the casing pipes these technology developments will be enhanced with a robust well design solution addressing challenges reducing project risk and enabling reduction of lcoe the new well concept will enable costeffective geothermal developments in new types of geological settings and new regions the compass consortium contains a diverse team of major geothermal research institutes and leading industry players this combination ensures crossfertilisation sharing of knowledge and experience and seamless transfer of the novel well construction technologies by industry application including significant citizen e |
developing novel inhaled bioengineered extracellular vesicle rna based advanced therapeutics delivered by tailored aerosol delivery technology for the treatment of lung cancer | lung cancer lc treatments have advanced in recent years with the advent of genetic profiling and immunotherapy however lc is a complex heterogeneous disease and survival rates remain poor rna mrna microrna other noncoding rnas and nucleic acid based modulators of same and gene therapies dna or gene editing for delivering nucleic acidbased therapeutics have curative potential for a host of indications previously untreatable they have yet to enter the mainstream due to safety concerns and difficulties delivering them efficiently to areas other than the liver kidney and circulatory system aerosol delivery allows direct targeting of lung tissues but viscous mucus in the lung is a significant barrier to gene transfer to the target cells of the lungs even if the mucus layer can be penetrated inefficient penetration through the cell membrane further impedes access of these vectors to the underlying target cells thus preventing successful gene transfer delivery is a major barrier to successful pulmonary gene therapy for competing viral and nonviral gene transfer vectors and the vast promise of gene therapy has many challenges to overcome omnis novel solution is pioneering the use of genetically modified msc evs with a proprietary surface engineering technology to further enhance delivery through the mucus barrier and into the targeted lung cells this platform technology also combines efficient aerosol delivery of the evs via aeros proprietary state of the art vibrating mesh nebulizer technology this unique solution solves the problems associated with lung targeted delivery of rna based advanced therapies |
deciphering cellular and viral determinants of lytic hsv1 infection latency and reactivation | herpes simplex virus 1 hsv1 is an important human pathogen which infects the majority of the worlds population and inflicts a substantial burden of disease over the past 10 years systems biology approaches to which my lab has provided seminal contributions have substantially broadened our understanding of the complex interaction of this common pathogen with its human host however the underlying molecular mechanisms remain poorly understood and their importance for virus latency and reactivation remain elusive furthermore currently available technology lacks the temporospatial resolution to decipher the cellular and viral determinants that govern the virus life cycle the main goal of decipherhsv is to close these knowledge and technology gaps and decipher novel mechanisms and their functional interplay by which hsv1 manipulates its host cells throughout the virus life cycle accordingly the three primary objectives of decipherhsv are to i decipher the full complement of viral elements that govern productive infection ii decipher how and why hsv1 manipulates pervasive transcription within the host and viral genome and iii decipher the cellular and viral determinants of hsv1 latency and reactivation alongside i will develop new computational approaches and integrative analysis tools and employ artificial intelligence to exploit the wealth of information that is provided by the novel single cell rna sequencing approaches which i will pioneer heterogeneityseq and perturbscslamseq thereby i will deliver new leads for novel therapeutic approaches targeting hsv1 latency and reactivation this will provide a paradigm for the study of other herpesviruses and their complex hostpathogen interactions |
bioinspired singlet fission photon multipliers | the european union eu revised renewable energy directive 20232413eu states the need of advancing renewable energy sourcesto meet the commitments of the paris agreement while keeping the eu a global leader in renewables among the existing renewableenergy technologies photovoltaics are one of the most mature promising to reach a worldwide production of 8519 gw by 2050siliconpvs sipvs are the most advanced approach to reach the above goal at low costs however they still face the problem ofthermalization an energy loss mechanism by which the excess energy of the absorbed photons with respect to the si band gap islost biosinfin will tackle this issue developing the first bioinspired photomultiplier coating based on singlet fission a multiple excitongeneration process here singletfission active chromophores and redemitting materials are bioconjugated to protein scaffolds withnm precision and used to fabricate a coating to sensitize si solar cells promising up to an additional 5 to the absolute powerconversion efficiency of commercial si pvs ie about 25 improvement using a lowcost and sustainable coating leading a revalueof sipv market of up to 15 this multiphoton protein family and its respective coatings will allow to realize a lowcost sustainable environmentally friendly and highly performing new generation of multiphoton lowenergy biohybrid emitters of great interest for photonics with a final proof on overcoming thermalization in silicon solar cells helping the eu to fulfil the revised renewable energydirective |
understanding the working mechanisms of quaternary blend organic photovoltaics opvs | in response to recent climate tragedies european union eu is taking rapid action with its ambitious european green deal egd to transform our economies and societies greener as a result the eu is encouraging the transformation of our buildings and vehicles from energy consumers to energy producers by installing lightweight flexible colourful transparent lowcost and environmentally friendly solar panels these are precisely the features of organic photovoltaics opvs despite the benefits the commercialization of opvs has yet to occur with power conversion efficiency pce being the primary impediment in recent years significant advancements in developing novel design architecture such as quaternary blend systems qopvs that employ cuttingedge nonfullerene acceptors nfas helped achieve pce of over 18 however a lack of understanding of the fundamental mechanisms behind novel qopvs has impeded further advancement as a result dr arunagiri lingeswaran experienced researcher er intends to solve this issue by employing advanced spectroscopic techniques to develop a new design rule for fabricating oneofakind and highly efficient qopvs that go beyond the stateoftheart er intends to bring an efficiency breakthrough in the opv field by utilizing the intermultidisciplinary aspects of research involving physics chemistry materials science and device engineering to achieve this ambitious goal using the host institutions excellent infrastructural resources the proposed project qubics complements the ers expertise in fabricating cuttingedge qopvs and the host scientists knowledge of studying device physics overall the new skills and expertise obtained via this fellowship will help er mature into a better researcher capable of managing his research group in a few years ideally in europe his desired career path |
next level quantum information processing for science and technology | quantum computers are extremely promising emerging technologies with interdisciplinary teams around the globe working on their development and implementation yet progress is hampered by fundamental difficulties in scalability enduser friendliness certification of components and algorithms and limited application scope to realworld problems to overcome these urgent challenges neqst leverages an extended quantum information processing paradigm based on multilevel carriers of quantum informationqudits both the quantum hardware at the fundamental level and many problems of scientific and technological relevance are expressed in terms of multilevel systems making this approach the most efficient choice to unlock the full potential of quantum computers and simulatorsneqst will generate foundational breakthroughs in the full value chain of qudit quantum information processing these include qudit based firmware with scalable characterization and automatized design tools harnessing a larger hilbert space an enduser friendly highlevel control and simulation software enabling nonspecialists to utilize the qudit hardware the efficient simulation of quantum models of scientific relevance such as gauge theories the solution of optimization problems in academia and industry naturally phrased in terms of multilevel variables and certification tools specifically designed for multilevel quantum information enabling a deviceindependent validation of data neqst results will therefore elucidate the role of dimension in quantum physics and its use as a resource for quantum information processingto achieve its ambitious goals neqst has assembled an interdisciplinary team of leading academic and industry partners and has developed a wellrounded work plan as well as detailed dissemination and exploitation strategies |
gap resolution in safety nutritional allergenicity and environmental assessments to promote alternative protein utilization and the dietary shift | accelerating the transition from animalbased to alternative dietary proteins the dietary shift is key to reducing the footprint of our food system in terms of greenhouse gas emissions ghg energy water and land use and other relevant environmental impacts and for improving the health and wellbeing of people animals and the planet giant leaps delivers the strategic innovations methodologies and openaccess datasets to speed up this dietary shift in line with the farmtofork strategy and contributing to the green deal target of reaching climate neutrality by 2050 achieving the dietary shift in practice is inherently complex due to the diverse set of actors involved and further hindered by major knowledge gaps scattered across the various alternative protein sources and the domains of health safety allergenicity and digestibility environment ghgs and other environmental and climate impacts biodiversity circularity andor barriers to adoption technological sensory and consumer acceptance the giant leaps consortium consists of the key actors and spans all expertise to address relevant knowledge gaps and proactively engages to arrive at optimized future diets based on alternative proteins that are broadly accepted across stakeholder groups in order to deliver required insights for short mid and longterm decision making and impact giant leaps protein sources have been selected for either targeted or full assessment based on their current level of specification the innovations and improved methods combined with accessible and comprehensive information generated for a wide collection of alternative proteins will enable policymakers to prioritise changes in the food system towards the dietary shift based on desired impact value chain actors to make strategic scientific business and investment choices and the general public to make more sustainable and healthy dietary choices |
flexible channel coding for 6g short packet communication | the emerging sixthgeneration 6g of mobile networks will be a key part of the solution to the constantly increasing problem of urbanization and the digital divide 6g has aligned its focus to the united nations sustainable development goals sdgs and aims by 2030 to achieve the following targets a empower people by providing services and solutions to individuals and society b sense the environment by performing extensive hyperlocal measurements and c strengthen the world by reinforcing the ecosystem according to the sdgs key 6g use cases such as wireless factory automation and autonomous driving will require ultrahigh reliability and ultralow latency highresolution localization and highaccuracy interdevice synchronicity these requirements are well beyond the capabilities of existing mobile standards including the fifthgeneration 5g mobile short packet communications play a key role in meeting the low latency requirements of many 6g applications despite recent progress the design of effective channel coding and decoding techniques for short packet communications is still far from sufficiency 6g communication systems require flexibility in the blocklength and coding rates short and moderate blocklength codes approx from 100 bits to a few thousand bits with closetooptimal performance are required for 6g a promising solution is rateless codes carefully optimized for short blocklength and able to provide flexibility in code rates blocklength and decoding complexity the main objective of this project is to develop new rateless coding schemes and decoding algorithms to address the flexibility and bitgranularity for finite blocklength channel codes and to design lowcomplexity decoding algorithms to address the latency issue in 6g short packet communications it is expected that our results can largely improve the performance of 6g networks in terms of latency reliability flexibility and complexity |
surgical optogenetic bioprinting of engineered cardiac muscle | heart failure remains a leading cause of mortality worldwide taking an estimate of 16 million lives each year cardiac tissue engineering solutions that can improve the quality of life of those with advanced heart disease have proved challenging so far bioprinting is an exciting technology that holds promise to fabricate tissues and organs labgrown engineered cardiac muscle requires at least four weeks to maturate in a bioreactor in lightheart an offtheshelf solution will be developed for treating injured myocardium in vivo an unconventional combination of bioprinting and optogenetics will be used to surgically fabricate engineered cardiac muscle directly at the patients heart a surgical bioprinting tool will be constructed to achieve vascularization and cellular architectures as that observed in native cardiac muscle induced pluripotent stem cellderived cardiac cells will be the basis of the bioinspired biomaterialfree ink that will be printed optogenetic expression of different lightsensitive proteins at the cell surfaces will be the sole trigger of cellular assembly thus omitting the need to embed cells in hydrogels or printing in a supporting bath surgical optogenetic bioprinting will be first tested ex vivo using a silicone human phantom with a mimicking beating heart and later in vivo in a large animal model in accordance with the 3r principles lightheart opens up new horizons in the way heart failure can be clinically treated and brings hope to patients who are desperately waiting for a heart transplantation the disruptive nature of lightheart will unite engineers surgeons and scientists to change the future of transplantation medicine with modular bottomup technologies that allow for in vivo tissue and organ restoration or replacement directly at the operating theatre |
nanoengineered coionic ceramic reactors for co2h2o electroconversion to light olefins | as a major contributor to the global co2 emissions the commodity chemical industry should be urgently coupled with renewable electricity to become independent from fossil fuel resources ecolefins aims to establish a new allelectric paradigm for the electroconversion of co2 and h2o to light olefins the keyintermediates for polymers and other daily life chemical products the proposed concept reverses the heavy co2 emissions associated to the petroleumbased light olefins production to massive co2 capture and valorisation for carbon negative ethylene propylene and butylene the concept introduces coionic ceramic membrane reactors and shortstacksmodules that merge the anodic steam electrolysis for hydrogen production with the cathodic co2 electrolysis and hydrogenation to light olefins over tailored and nanoengineered electrodes aiming to develop a substantially more effective technology for the singlestep respowered artificial photosynthesis of co2 to valuable chemicals this ambition entails a multidisciplinary task requiring highly tuned synergies among cutting edge research in the fields of i advanced materials science engineering for coionic composites perovskite exsolutions and organometallics ii electrochemistry and electrochemical process engineering iii catalysis science and engineering iv computer aided materials design and atomic scale modelling and v digital realscale process modelling and economic evaluation along with a comprehensive sustainability assessment applied social research for impact framing and marketization planning |
early interception of inflammatorymediated type 2 diabetes | the overall concept of interceptt2d is to establish whether an inflammatorymediated profile contributes to the onset of type 2 diabetes t2d complications thus enabling the identification of patients most at risk of complications and the design of personalized prevention measurest2d is a heterogeneous disease which is an obstacle to the delivery of an optimal tailored treatment consequently patients individual trajectories of progressive hyperglycemia and risk of chronic complications are so far difficult to predict in this context onset of diabetic complications represents the most important transitional phase of t2d development toward premature disability and mortality chronic systemic inflammation has been suggested to be a major contributor to the onset and progression of t2d complications interceptt2d will bring a new and clinically relevant dimension in t2d care considering at diagnosis inflammatory parameters that are of importance for the transition to t2drelated complications the combination of stateoftheart genomics and cellbiology technologies with targeted clinical interventions should lead to potent patients stratification it should allow the identification and prognosis of a novel class or subclass of patients characterized by an inflammatorymediated t2d endotype the project has access to the bestdocumented longitudinal human european cohorts of patients with t2d with reliable clinical and biological data allowing to trace the transition and evolution towards organ complications this added to the exploitation of an extensive health data warehouse will enable us to establish the inflammatory trajectory of citizens with t2d from diagnosis to the development of complications to explore the ability to prevent the transition phase of t2d towards organ complications interceptt2d will conduct a phase ii clinical trial with an antiinflammatory therapy targeting nlrp3 inflammasome activity in patients with t2d |
a comprehensive translational research and training pipeline harnessing lipid metabolism to improve prostate cancer management and educate young researchers in tackling complex disease | prostamet is an immersive doctoral network dn that aims to train the next generation of researchers tackling complex multifactorial diseases including cancer that are typically characterized by an outspoken inter and intrapatient heterogeneity and that increasingly face our ageing society despite unprecedented technological advances to dissect disease into its smallest details the translation into costeffective and personalised treatment approaches is one of the timeliest challenges that face the scientific community and that require a specific transdisciplinary mindset and education focusing on prostate cancer as a key paradigm of such a complex disease and as one of european health unions new focus areas for organised screening prostamet aims to bridge current gaps in translational research capitalising on the underexplored clinical potential of altered lipid metabolism in cancer through a close collaboration among wellselected academic and nonacademic partners with highly complementary expertise prostamet aims to set up a unique lipidfocused translational research pipeline from cuttingedge spatiallyresolved molecular discovery through validation in goldstandard models all the way to innovative drug development through its modular and bidirectional nature with multiple entry points this pipeline is expected to generate outputs at multiple levels of the drug development chain for sustainable downstream valorisation through a combination of highlevel technological handson research nonacademic placements and coursesworkshops on scientific and complementary soft skills facilitated by the academicnonacademic composition of the consortium prostamets ambition is to provide young researchers with a creative and holistic view on translational research along with strong transferable skills to prepare them to take up thriving careers in a transformative health care system focusing on personalised precision medicine |
port solutions for efficient effective and sustainable multimodality | multireload focusses on the specific role and challenges of inland ports as multimodal freight nodes in reaching europes greenhouse gas ghg reduction target of at least 55 by 2030 thereby shifting a substantial part of the 75 of inland freight carried today by road in the eu to inland waterways and rail and by increasing operational efficiency safety and reliability of existing infrastructures through digitalization inland ports are key for multimodal transport chains both continental and maritime transport without efficient nodes in the hinterland multimodal transport is not possible however the constraints and barriers are much higher in inland ports space urbanisation demand investments than in seaports multireload enhances the collaboration between different freight nodes in europe to jointly test innovations and create favorable market conditions for multimodal freight transport solutions multireload will demonstrate solutions in three innovation areas with specific aims by 2025 mirroring measures of the eus smart mobility strategy a smart multimodal logistics facilitate a shift from road to rail iwt of 5 b digital automated multimodal nodes and corridors increase operational efficiency by 20 raise of handling capacity c innovative business models leading to an average cost reduction of freight transport by 10 multireload involves highly ambitious logistics hubs including the multimodal node duisport de duisburgs highly ambitious port and the worlds largest and most advanced trimodal inland hub terminal and the trimodal nodes ports of vienna at and basel ch the project is backed up by additional funding financing for better integration of the freight transport nodes into overall logistic chains of about 450 mio eur multireload involves a total of 22 partners comprising of highly innovative technology logistics and service providers leading european research institutions and wellconnected networks |
microscale enabled advanced flow and heat transfer technologies featuring high performance and low power consumption | with the emergence of industry 40 electronic and digital devices are incorporated into almost all high tech applications there has also been a notable shift towards compact electronic devices which requires more intense operating powers leading to enormous heat dissipation thus whilst devices are increasingly becoming portable and powerful thermal management techniques are arguably not catching up at the same rate hence continuous improvement and innovative approaches are needed in this regard microchannelbased techniques present innovative possibilities to tackle thermal management and cooling issues in modern appliances across various industries aligning with the trend to adopt more sustainable approaches and the eu 2016 legislation for heating and cooling consequently our microflotec project adapts an international multidisciplinary and collaborative approach to exchange expertise from 17 research institutions and two industrial partners to trigger significant advancements and agile development for heat transfer and thermal management solutions the consortium shares robust experience and skills related to heat transfer enhancement largescale electrical energy storage via thermal processes new generation materials science multiphase flow flow and heat transfer of hightemperature rotating parts design and modelling for energyefficient control systems marketing and entrepreneurship skills amongst others based on the appraisal of the current stateoftheart literature and technologies we aim to tackle problems within morphological optimization of multiphase heat transfer performance and flow resistance reduction surface modification techniques and application of multiphase physics for performance prompting our project will hopefully achieve costeffective and sustainable solutions initiate future advancements and investigations and contribute towards the eus 2050 longterm strategy for climate and energy saving goals |
bios the biointelligent dbtl cycle a key enabler catalysing the industrial transformation towards sustainable biomanufacturing | the usage of fossil resources leading to increasing atmospheric co2 levels and global climate change should be rapidly replaced by implementing a circular economy circular bioeconomy converting sustainable substrates in moderately operating bioprocesses offers a plenitude of solutions while synthetic biology provides a multitude of tools for strain engineering their rapid use in hosts for optimal performance under industrial conditions is still challenging promising innovations are often trapped in the valleyofdeath as strain engineering faces a too complex space of putative manipulations novel approaches are needed to increase speed and success rate of strain and bioprocess engineering the biointelligent approach rigorously applied in bios aims to accelerate and improve the conventional designbuildtestlearn dbtl cycle for strain and bioprocess engineering interdisciplinary collaboration will bridge microbiology molecular biology biochemical engineering with informatics automation engineering and mechanical engineering novel innovative metrics biosensors and bioactuators are developed for bidirectionally communication at biologicaltechnical interfaces digital twins are created mimicking cellular and process levels integrating ai not only improves prediction quality but also enables hybrid learning the key reason to increase speed and success rate in the novel biointelligent dbtl cycle bidbtl the power of bidbtl will be showcased by creating p putida producer strains for terpenes polyolefines and methylacrylate all are highly attractive products with a high potential for reducing anthropogenic greenhouse footprint bios will open the door to a decentralized networked collaboration for strain and process engineering that efficiently links individual expertise for the sake of a symbiotic and rapid progress bios also paves the way to decentralized biomanufacturing by implementing autonomous selfcontrolled bioprocesses |
dynamic control of gaussian morphing structures via embedded fluidic networks | transforming a flat plate into a doubly curved shell is not possible without distorting inplane distances as stated by gauss in his seminal theorem in natural morphogenesis this strong geometrical constraint is overcome by differential growth in the tissues which induces mechanical stresses and thus the buckling in a rich variety of shapes over the last decade emerging approaches have embraced this paradigm to develop bioinspired synthetic responsive materials with inplane distortions and hence shapemorphing capabilities however despite rapid developments current efforts primarily focus on programming the final equilibrium shape overseeing the dynamical trajectory of the transformation but also the mechanics of the morphed structure as a result exciting biomedical applications perspective in minimally invasive surgery rehabilitation and soft robotics remain so far elusivehere i aim to develop structures in which the shape but also the mechanics and the dynamical deformation trajectory may be programmed in time to do so i propose to develop hybrid elastic plates embedding a network of fluidfilled cavities first i will generalise design principles to create unit cells that dispose of all six deformation modes both inplane and outofplane when pressurized assembling such cells will enable univocal shape selection but also internal degrees of freedom to control the frustrated mechanics then i will unravel the coupling between fluid viscosity and cavity geometry to spatially control the homogenized viscoelastic property of the material the subsequent timescales will be finally used to program the dynamical deformation trajectory of the structure when submitted to a mechanical or fluidic loadtaken together i propose to develop new experimental standards and theoretical frameworks to pave the way for the first fully controllable shapemorphing materials with applications for adaptive peristaltic endotracheal cuffs in view |
amenable cdynamics and their classification | our understanding of amenable calgebras has drastically improved over the past decade due to substantial advances in the elliott classification program the proposed research is intended to spearhead the classification and structure theory for cdynamics which encompasses groups acting continuously on calgebras and the question to which extent their detailed structure is encoded at the level of computable invariants the objectives involve the following lines of investigation the case of discrete groups acting on simple amenable calgebras the latter of which have become accessible due to recent methodological breakthroughs within elliotts program the task is to develop a dynamical version of elliotts program ie to consider natural categories of such group actions identify functorial invariants such as ktheory and traces and show that these invariants completely classify a naturally occuring category up to a suitable notion of isomorphism the theory of invariants for noncommutative cdynamics this field is faced with numerous open problems requiring solutions before a fully general classification theory can be developed this part of the project addresses the need for effective computational methods for equivariant kasparov classes or systematic techniques to exploit equivariant exttheory for the purpose of classification the case of noncommutative time evolutions which includes new rigidity phenomena for the passage of time in simple calgebras both with and without the presence of equilibrium statesa deeply rooted theme within all these objectives is the presence of amenability for the actions and the calgebras which gives rise to radically new phenomena in the context of nonamenable acting groups drawing ideas from diverse areas such as the elliott program equivariant kasparov theory classical and noncommutative ergodic theory novel methods are proposed to achieve groundbreaking results in the area of cdynamics |
research and innovation strategy for lviv polytechnic national university dedicated to whiteemitting organic lighting systems | helios aims to elevate the scientific excellence and innovation capability of lviv polytechnic national university lpnu and its esteemed twinning partners kauno technologijos universitetas university of glasgow rgas tehnisk universitte and intelligentsia consultants sarl their research component target is the creation of whiteemitting organic systems for lighting over three years they will follow a research and innovation strategy spread across five core objectives and eight work packages objective 1 focuses on exploratory research to design ultraefficient singlemolecular white emitters for woleds and wleds aiming for a significant breakthrough in solidstate lighting costperformance objective 2 centers on knowledge transfer between experienced researchers from lpnu and its twinning partners activities will involve staff exchanges trainings and seminars to reinforce the research from objective 1 objective 3 aims to boost career opportunities for earlystage researchers of both lpnu and the twinning partners methods will include short to medium exchanges training workshops summer schools and a shared phd programme objective 4 is geared towards refining lpnus project management skills specifically in proposal drafting and managing european rd funding projects objective 5 is committed to elevating the research stature of lpnu and its twinning partners they intend to achieve this via widespread dissemination communication and outreach initiatives |
advancing uavs technology to enable monitoring for a sustainable environment | unmanned aerial vehicles uavs are emerging as powerful tools for sustainable environmental monitoring playing a vital role in comprehending the diverse effects of climate change on ecosystems the integration of state of the art techniques such as artificial intelligence ai with uav technology has introduced innovative pathways for various environmental applications however their full potential remains to be explored accelerate proposes the development of a fertile interdiscipline and intersectoral ecosystem that aims to radically contribute towards enhancing uav technology to enable the sustainable environmental management the specific objectives of the project are to a create a continuously updated ecosystem with uav datasets suitable for environmental studies and climate change impact assessment b promote methodological advances in the field of uavs technology by exploiting the unique capabilities of those data with stateoftheart techniques and c establish clear guidelines and homogenized protocols for the characterization of the exploitation of uavs in specific application domains experimental analysis will also be carried to showcase the practical use of the project outputs via four carefully selected and innovative use cases that will serve as key performance indicators of the project accelerate brings together enthusiastic staff from academia and industry via a series of carefullydesigned secondments establishing a unique fertile collaborative research and innovation environment to promote pioneering research in environmental and socioeconomic studies implementation within urban natural and agricultural environments a strong intersectoral experienced research team of 17 partners from 9 countries of 9 academic and 8 industrial partners coming from greece 2 romania 3 italy 2 cyprus 1 united kingdom 5 north macedonia 1 france 1 germany 1 and portugal 1 constitute the projects consortium |
transcranial photobiomodulation for motion sickness mitigation | cyber and motion sickness are debilitating for many people limiting both travel opportunities and the use of new technologies such as virtual and augmented reality these forms of sickness are due to nauseogenic sensory mismatch nsm cybersickness affects up to 50 of people use who ar and vr headsets motion sickness affects 30 of travellers in all forms of transport with even more getting sick if they use ar or vr as a passenger to mitigate the effects of nsm the photomod project will demonstrate the efficacy of a novel transcranial photobiomodulation tpbm technique using nearinfrared light this is delivered by leds on the scalp shining invisible light into the brain focused on the human vestibular network hvn to create neural entrainmentour novel method extends work on the erc viajero project which used transcranial alternating current stimulation to create entrainment in the hvn we use this to synchronize the phase information of endogenous neural oscillations associated with nsm in the hvn to an external phase stimulus generated by tacs which mirrors healthy phase information we have found very significant benefits for nsm with this method however tacs has many drawbacks for commercial application tpbm overcomes all of these as it is more precise safer more comfortable and cheaper in photomod we will develop new hardware and software to deliver tpbm in a commercial form then test it as a mitigation for cybersickness at home and for motion sickness on the road the final result will be a commercialisable wearable system that can mitigate the effects of cyber and motion sickness across a wide area of applications |
optimal power conversion and energy storage system for safe and reliable urban air mobility | the research proposal addresses the design challenges in the power conversion and the energy storage systems in the electric aircraft used for urban air mobility uam the success of uam as an alternate transportation system is strongly dependent on designing the overall system to be safe efficient and reliable this proposal focuses on improving the power conversion efficiency and designing a smart wireless battery management system bms with accurate battery stateofcharge soc and stateofhealth soh estimations another desirable aspect in the uam aircraft is improving the overall payload capacity which is impacted by the weight of the batteries interconnection wiring and power conversion efficiency the proposal aims to improve it by increasing the voltage of the liion battery packs above the current stateoftheart which would reduce the current rating and cable weight while identifying a power converter topology to maximize the overall efficiency the design optimisation will consider the impacts of higher insulation requirement with higher voltages and overall cost the power converter topology and the accompanying filters are optimised to reduce electromagnetic interference that can affect the sensitive electronics on the aircraft the proposal explores datadriven machinelearning based methods to improve the accuracy of the soc and soh estimations and reduce the gap between peak error and the rootmeansquare error rmse a reduction in the gap between peak and rmse will provide a reliable upper bound unlike for the case when estimation methods show a lower rmse but a wide variation in the peak error the wireless bms will provide the advantage of easier maintenance and elimination of the conventional wiring weightthis is a timely and innovative project that will help in novel technology development for uam industry it will help the applicant gain additional technical and managerial skills that would ensure a successful research career |
rural landscape heritage and carbon sequestration | with the ongoing climate emergency and nations commitments to meet netzero carbon emissions by 2050 there is a heightened need to contrast climate change through sustainable landuse lu strategies agroforestry af has existed since ancient times in european countries and it has been recognised as one of the most beneficial rural lu systems the rhecast rural landscape heritage and carbon sequestration project aims to develop a new interdisciplinary approach to investigate the interactions between sustainability and rural landscape heritage with particular reference to co2 sequestration over the long term the project will take an interdisciplinary approach that combines landscape archaeology hlc historical landscape characterisation computerbased modelling msd multisector dynamics and archaeological soil geochemistry asg and it will focus on one of the main european hot spots of atmospheric pollution the po venetian plain pvp italy the main project innovation will be to develop an msd model using hlc data to determine which would be the effect on climate change mitigation by recasting the current pvps industrial agriculture with historical af asg will be essential to constrain the msd model results leading to significatively more precise outcomes of past and potential future co2 sequestration thus the rhecast project aims at modelling co2 sequestration rate of historical af to inform sustainable landscape management plans that will maximise climate change mitigation whilst preserving the regional cultural identity by applying a range of innovative and interdisciplinary techniques the project will be able to develop a model that could be potentially extended in other european regions with similar historical and environmental characteristics eg dehesa spain montado portugal pluiny czech republic streuobst germany |
humancentred generative ai framework for cultural industries digital transition | humancentred generative ai framework for cultural industries digital transition hamlet aims to democratize access to generative ai in europes cultural and creative industries ccis its mission is to make generative ai benefits accessible to entities of all sizes in order to foster a sustainable digital transition the strategy involves integrating a digital collaboration platform the hamlet collaborative community hub enabling entities across different sectors to pool investments share facilities exchange competencies and employ shared investment and profitsbased collaboration models in parallel hamlet produces 7 diverse ai enablers for ccis as demonstrators of the framework which streamline the creative process these enablers are designed to be integrative promoting collaboration by facilitating seamless interactions and project cocreation among various cci stakeholders by intertwining these two core components hamlet not only provides the technological infrastructure necessary for embracing digital transformation but also cultivates an ecosystem where collaboration and shared success are the norms moreover hamlet is committed to exploring and researching novel business models including mechanisms for profit sharing and equitable distribution of benefits derived from collaborative efforts aiming to lower barriers to ai adoption and to establish sustainable frameworks that incentivize shared success and innovation this cohesive approach ensures that barriers to adopting ai technologies are significantly lowered enabling a more inclusive and dynamic creative sector that is equipped to navigate the complexities of the digital age through hamlet smaller actors of the european ccis are empowered to explore new horizons of creativity and innovation solidifying europes position as a global leader in cultural and creative excellence hamlet will be tested through 4 pilot cases involving different cci sectors across 4 countries in europe |
training young researchers on shaping metaverse for business and social value agora | as metaverses operate in realtime their wide adoption is expected to create digital public spaces for interaction in which the already possible online interactions are intensified and blended with the physical world as never before to lead in this field and maximize positive implications europe needs to ensure that new multidimensional challenges arising are addressed in accordance with european values agora responds to the lack of doctoral programs which go beyond the technical understanding of metaverses and consider its business and social value while unpacking and addressing potential unintended consequences through a rigorous and robust research and training programme agora aims to develop a critical research and talent base capable of leading by example agoras approach is to train the researchers not only to understand metaverses infrastructure but also to understand and oscillate between the different levels of metaverses business and societal value paving in this way a more integrated understanding of this disruptive ecosystem combining theoretical and handson industrial research and transferable skills training will enable researchers to target highquality publication outlets and to become creative and autonomous so that they can exploit and commercialize research results and become competitive in the global arena one of agoras unique selling points is its ability to prepare the esrs to work in any of the three pathways academia industry policy making as well as their intersections agoras intersectoral network brings together leading academic and nonacademic cosupervision arrangements of high quality stimulates the development of new industrial doctoral training procedures between top business schools and industries in the region |
intersectional exile irishiberian identities and the comparative translation of diaspora 15921642 | this public and digital humanities project will carry out cuttingedge research on identity formation at the dawn of the modern nation state in 1492 after defeating the last stronghold of the moors in granada the spanish monarchy consolidated its power through a series of religious and political reforms this not only led to a harrowing century of exile for jewish and islamic populations but also a time of refuge for irish catholics fleeing from the cultural oppression of english expansion in each case they used multilingual writing to maintain a sense of community in societies fuelled by the paranoia of religious and ethnic purity their records thus offer insight into the formative relations between language identity and historical discrimination yet the materials left by irishiberian exiles often remain little known even among scholarsintersectional exile will address this gap by researching translating and publicly presenting a selection of early modern materials from the salamanca archive a rarely studied collection of perspectives written in spanish by irishiberian exiles the msca fellowship will make this possible through key access to the current location of the salamanca archive at the national university of ireland maynooth hereafter nuim and contextual materials in its original location at the universidad de salamanca hereafter usal when combined with the professional guidance of prof valerie heffernan nuim mentor as well as rare irishiberian expertise of scholars like prof thomas oconnor further nuim support and prof javier burguillo usal secondment mentor the project will add vital nuance to scholarly theories and histories of intersectionality in doing so the experienced researcher hereafter er dr laura francis will also address the council of europes urgent call to understand the roots of current migration biases and face past injustices through memorialisation and education |
creating an orthogonal gate to the brain | many impairing illnesses raging from metastatic cancers to neurodegenerative diseases affect the brain unfortunately delivery of therapeutics to the brain is highly challenging due to the bloodbrain barrier bbb despite decades of research no safe and efficient strategy to overcome this barrier has reached clinical application here we propose a concept that will revolutionize brain transport creating a new orthogonal receptor to mediate transport across the bbb numerous molecules have been developed to achieve brain delivery via receptormediated transport however delivery is very limited presumably because no receptor combines 3 key features high transport efficiency high expression on the bbb and low expression on peripheral tissues this results into peripheral tissues acting as a sink and dramatically lowering the therapeutic index of drugs aimed for the brain the greatest limitation of current efforts is trying to solve both selectivity and efficient transport in a single delivery vehicle our unprecedented approach is based on dissecting this problem in two increasing transport efficiency with the new orthogonal receptor obgate and addressing selectivity with a highly efficient targeted vehicle to express the receptor only at the bbb since this receptor will not bind any endogenous ligand its properties and intercellular trafficking can be engineered with minimal alteration of brain homeostasis this will enable to unravel the key determinants of bbb transport and to build an ideal transport system selective expression of this receptor in the brain endothelium will be achieved by engineering a gene delivery nanocarrier mimicking the twostage viral entry into bbb cells as an example to prove the efficiency of our system we will aim to deliver biotherapeutics for the treatment of brain metastatic breast cancer overall we will open a new gate to the brain that is poised to be paradigmbreaking in the treatment of neurological diseases |
spacebased composite adsb and multilaterarion system validation through scalable simulations | satera will propose and validate an integrity estimator for spacebased adsb systems based on crosschecking positions reported in adsb messages with position estimations provided by spacebased mlat systems to reach this goal satera will apply a stepped approach starting by the definition of an initial osed providing a highlevel operational description at system level identifying all the involved stakeholders and detailing the cns equipage of the fleet and the available air traffic services then satera will adapt the system architecture described in the ed142a for a composite groundbased surveillance system providing adsb and wam surveillance to cope with the particularities of a spacebased system next the research team will develop theoretical models to assess and benchmark the proposed system architecture leading to a full list of functional requirements and interfaces description that will be captured in a functional description document satera will also adapt for a spacebased system the performance requirements it has to meet according to the ed142a for enrlowmediumhigh traffic densities afterwards satera will develop a system performance prediction tool to compute the theoretical performance of a mlat system whose receiving stations are onboard of a constellation of leo small satellites this tool will take into consideration all the error sources that can affect the mlat system performance and will be used to update the initial osed if needed and system architecture and to select the most suitable constellation for validating the satera solution at trl2 using an endtoend system evaluation tool that will be developed by the research team as an evolution of the system performance prediction tool the trl2 validation will consist of several validation exercises addressing the provision of composite spacebased adsbmlat surveillance in the eursam and nat corridors for realistic traffic |
clean energy transition partnership | the clean energy transition partnership cetp is a transnational initiative on joint rtdi programming to boost and accelerate the energy transition building upon regional and national rtdi funding programmesit aims to empower the energy transition and contribute to the eus goal of becoming the first climateneutral continent by 2050 by pooling national and regional rdti funding for a broad variety of technologies and system solutions required to make the transition it will foster transnational innovation ecosystems from the very local and regional level up to the transnational european level thus overcoming a fragmented european landscape the cetp is aiming to enable 70 national and regional rdti programme owners and managers from 32 countries to align their priorities and implement annual joint calls from 2022 to 2027 original first proposal as published by the ec on cordis actually 30 countries and 55 programme owners and managers formally participate in this initial grant agreement they also organise joint accompanying activities to enable a dynamic learning process extract strategic knowledge knowledge community and maximise the impact impact network to accelerate the upscaling replication and market diffusion of innovative solutions this will foster the uptake of costeffective clean energy technologiesthe common vision of the cetp is already manifested in its strategic research and innovation agenda sria that has been cocreated in a broad engagement process during 2020 together with the involved countries the eu setplan implementation workin groups and etips all energy relevant eranets as well as the eera joint programmes over 500 editors coauthors commenters and discussants the sria was endorsed together with the european commission dg rtd and ener in november 2020 this articulates the common goal of 1 building a transnational transformative joint programming platform 2 developing and demonstrating technology and solutions for the transition of energy systems and finally 3 building innovation ecosystems that support capacity building at all levels |
quantifying islamic law in the modern state sharia in moroccan courts 19122012 | this mscapfef project proposal investigates the role of sharia islamic law in the contemporary national legal systems focusingon the case of morocco from 19132012 i combine digital humanities methods with qualitative text analysis to trace the conceptual and functional development of sharia i hypothesize that sharias practical function is best understood through court cases rather than classical prescriptions or state legislation of it alone using approximately 1400 sharia appeals court records collected during my doctoral fieldwork i will construct a multivariable sharia court database the database will be a firstofitskind data record of case variables including appellate decisions evidence types geography and source material citation with this database and the conclusions i derive from it i will embark on a series of publication scholarly collaboration and public outreach efforts on sharias contemporary role in the world the publications include three scholarly articles a collected volume on islam and colonialism based on a conference that i organize and a book proposal based on this research public outreach efforts include a public lecture series on colonial islamic legal practice syllabi on understanding colonialism and understanding contemporary islam for high school students and an online presence sharing results and analysis finally the database will be published open access online at the end of the fellowship both to aide researchers or stakeholders and to propose a model for assessing sharia courts worldwide as many state governments ngos and legal scholars continue debating sharias role in the twentyfirst century my project will present a strong historically grounded paradigm of sharias contemporary function in state courts |
giving rural actors novel data and reuseable tools to lead public action in rural areas | representing 30 of its population and over 80 of its territory eu rural areas are facing simultaneous demographic climate economic social and environmental changes which affect their characteristics and metabolisms responding to these challenges requires a precise understanding of what rural areas are and what rural communities are facing nowadays definitions of rural areas tend to lean on population density or size they do not provide sufficient insights into the dynamics drivers and fluidity of contemporary diverse ruralurban relations and identities that characterize ruralities across europe despite the increasing acknowledgement that rural areas are diverse and that typologies should better reflect the identities of such territories the lack of data at a fine scale prevents such innovations departing from an updated conceptualisation of rurality based on the multidimensional nature of contemporary ruralurban interrelations and interdependencies granular will generate new insights for characterising rural diversity based on a multiactor and interdisciplinary approach based on insights from multiactor labs it will generate novel datasets using a wide range of methods and primary data such as remote sensing crowdsourced data mobile phone data and webscraping this data will then be combined with a variety of existing institutional data to derive indicators relevant to rural communities for the implementation of the longterm vision for rural areas ltvra so to measure resilience wellbeing quality of life and attractiveness this will enable granular to create a rural compass that take into account the factors affecting rural communities and their functional characteristics informing policymakers and rural actors for the design of tailored rural policies after ensuring the upscalability of the results datasets data visualization and other tools will be directly available on a dedicated platform designed by and for rural actors |
co2 routes across europe | coreu will demonstrate key enabling technologies in a ccs value chain and support the development of three new ccs routes in centraleast europe cee helping accelerate ccs development coreu will a provide the means for development of an openaccess transnational network infrastructure and logistic to connect emitters with storage sites in europe by identifying multimodal transport requirements and developing emitters clusters to create the demand and the investment rationale b increase the knowledge of the ccs value chain across europe through interconnected initiatives sharing of experience knowledge and data to create a common framework that encompasses all key aspects of ccs deployment technological knowhow business models consensus management monitoring reporting and validation policy framework transport and storage safety coreu will contribute to 68mtyear in co2 reduction by 2035 and 36mtyear by 2050 develop 8 innovations for measurement monitoring verification interoperability and value chain monitoring and improve the internal rate of return of co2 infrastructure investment by 6 through derisking core technologies |
hydrogenbased intrinsicflameinstabilitycontrolled clean and efficient combustion | chemical energy carriers will play an essential role for future energy systems where harvesting and utilization of renewable energy occur not necessarily at the same time or place hence longtime storage and longrange transport of energy are needed for this hydrogenbased energy carriers such as hydrogen and ammonia hold great promise their utilization by combustionbased energy conversion has many advantages eg versatile use for heat and power robust and flexible technologies and its suitability for a continuous energy transition however combustion of both hydrogen and ammonia is very challenging for technically relevant conditions both form intrinsic socalled thermodiffusive instabilities very different from the oftendiscussed thermoacoustic instabilities which can increase burn rates by a stunning factor of three to five without considering this computational design is impossible yet while linear theories exist little is understood for the more relevant nonlinear regime and beyond some data and observations virtually nothing is known about the interactions of intrinsic flame instabilities ifi with turbulence here rigorous analysis of new data for neat h2 and nh3h2blends from simulations and experiments will lead to a quantitative understanding of the relevant aspects from this a novel modeling framework with uncertainty estimates will be developed the key hypothesis then is that combustion processes of hydrogenbased fuels can be improved by targeted weakening or promotion of ifi and that this kind of instabilitycontrolled combustion can jointly improve efficiency emissions stability and fuel flexibility in different combustion devices such as sparkignition engines gas turbines and industrial burners guided by the developed knowledge and tools this intrinsicflameinstabilitycontrolled combustion concept will be demonstrated computationally and experimentally for two sample applications |
resolving mechanisms of microbiome rescue to promote resilience to climate change | earths climate crisis threatens to disrupt ecosystem services and destabilize food security communities of microorganisms called microbiomes provide critical functions that feedback on climate and support soil and plant health i propose a new framework microbiome rescue to recover microbial populations and lost functions after disturbances with critical knowledge about the ecology of microbiomes and their contributions to creating resilient systems i propose that we can achieve a paradigm shift in ecosystem management via directed microbiome interventions here i focus on elaborating rescue strategies that leverage the selective reactivation of dormant microbes because microbial dormancy is extensive in soil and the rhizosphere reactivation offers access to untapped biodiversity and provides immediate solutions for maintaining functions in ecosystems affected by climate change my first objective is to understand and predict the capacity of dormant soil microorganisms to rescue microbiomes in a changing climate and discover reactivated bacteria that facilitate resilience my second objective is to investigate and develop bacterial reactivation for rescuebased microbiome management to support plant resilience to climate change stressors and preserve plantsoil feedback to achieve these goals i will execute three multifactor experiments to reactivate the dormant microbiome from soil and plant systems after exposure to heat and moisture stress first i will perform a heat and moisture experiment for european soils assess risk and curate microbial collections that support functional rescue next i will perform two practical rescue experiments for the microbiomes of legumes exposed to heat and moisture stress customized microbiological amendments and hostmicrobiome engineering this work will provide unprecedented insights into microbiome rescue and identify targets for biological interventions to support soil and crop resilience to climate change |
developing trustworthy artificial intelligence aidriven tools to predict vascular disease risk and progression | the aim of vasculaid is to predict the risk of cardiovascular events and progression of the vascular diseases abdominal aortic aneurysm aaa and peripheral arterial disease pad to influence the course of disease improving the patients quality of life and care and assisting clinicians to make betterinformed decisions involving the patient vasculaid will allow us for the first time to identify patients who are at high risk for aaa growth or pad progression and cardiovascular events to this end we will deliver a clinically relevant and costeffective trustworthy aidriven platform vasculaid that integrates multisource parameters including imaging proteomic and genomic data as well as lifestyle patient data from wearables to enable personalised vascular disease management to maximise the personalised prevention strategies vasculaid leverages visualisation tools to improve clinicianpatient communication and empower the patient the vasculaid platform consists of ai riskprediction tools a patient communication app an a clinical dashboard to support clinical decisionmaking a particular emphasis is placed on ethics to ensure beneficial implementation of ai prediction toolsin this project we aim to 1 build an euwide data infrastructure 2 develop an aibased progression prediction tools for aaa and pad 3 develop criteria according to the comet initiative to assess the effectiveness of vasculaid and 4 clinically test and show proofofconcept for the vasculaid platform once validated this platform can be extended to other cardiovascular diseases cvds as well vasculaid brings together 14 leading organisations and 2 affiliated entities consisting of clinical academic centres institutes universities and smes as well as large industry patients organisations and policy makers that cover the full value chain to enable integration of the platform into clinical practice |
extremophile cyanobacteria as life supporters for mars colonization | the curiosity and the interest of humanity in space exploration lead to important discoveries on fundamental questions about our place in the universe and push forward the development of new technologies new industries and important international relationships mars is the nearest planet to earth has evidence of water an element essential for life and a geological history similar to earth these characteristics turn it a source of inspiration and a possible home for humans in the future however it is an inhospitable place and several solutions are being pursued in order to help terraform the planet atmospheric composition cosmic radiation temperature and the lack of a protective magnetic field are just a few of the problems that humankind needs to face prior to considering mars colonization however there is a group of organisms that can be used to help solve some of the problems cyanobacteria why because they are simple oxygen producer organisms with low nutritional requirements and able to live in a wide range of extreme conditions and ecosystems moreover cyanobacteria can also be used as food sources to produce biofuels in bioremediation and as biofertilizers for instance and already proved to be good candidates for the task marcyan has the major goal of investigate the possible use of cyanobacteria to support mars exploration how using extremophile cyanobacteria isolated from a mars analog site rio tinto spain and submitted to marslike conditions in specialized planetary simulation chambers moreover marcyan intends to go beyond the conventional knowledge and will use transcriptomic and metabolomic analysis to uncover the possible mechanisms that can help to explain the survival of these organisms to extreme conditions opening the door to a more conscious choice of the best organisms to be used in space exploration |
building a european strategic research and innovation area in direct synergy with eu and international initiatives for pandemic preparedness | the covid19 pandemic has confirmed and further highlighted the importance of planning and investing in research and innovation well before a health crisis occurs for this purpose the main goal of be ready is to build a consolidated european research and innovation area that provides the foundation of the candidate european partnership for pandemic preparedness so to improve the eus preparedness to predict and respond to emerging health threats by better coordinating funding for research and innovation at eu national and regional level towards common objectives and an agreed strategic research and innovation agenda the partnership is expected to build on existing pandemic preparedness networks and work in synergy with the health emergency response authority hera in close collaboration with ecdc ema and other relevant international and european actors be ready is composed by 24 organisations from 15 countries with complementary expertise and policy area ranging from public health organisations ministries of science university health innovation or environment and research performing organisations that ensures a crosscutting interdisciplinary global health and one health approach |
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