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10.15252/embj.2020107257 | The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector | 2022 | Figure 7 | <p><strong>Figure 7. PUB4 ubiquitinates non-active BIK1.</strong></p><p><strong>(A) PUB4 has auto-ubiquitination activity <em>in vitro</em>. PUB4 autoubiquitination assay using His-Ubiquitin, UBA1 (E1), HA-UBC8 (E2) and MBP-PUB4 or MBP-PUB4 Cys239Ala inactive mutant reconstituted in bacteria. Ubiquitinated products wer... | https://api.sourcedata.io/file.php?figure_id=50314 | [
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10.15252/embj.2020107257 | The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector | 2022 | Figure 8 | <p><strong>Figure 8. BIK1 accumulation is dually regulated by PUB4 and negatively affected by RipAC.</strong></p><p>(A) Analysis of BIK1-HA protein accumulation in <em>BIK1-HA<sup>+</sup>/<sup>-</sup></em>, <em>pub4<sup>-</sup>/<sup>-</sup> BIK1-HA<sup>+</sup>/<sup>-</sup></em>, and <em>PUB4-FLAG<sup>+</sup>/<sup>-</su... | https://api.sourcedata.io/file.php?figure_id=50315 | [
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10.15252/embj.2020107516 | Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop | 2021 | Figure 1 | <sd-panel> <p><strong>Figure 1. Plx1 binds to Apc1-loop<sup>500</sup> via its Polo-box domain.</strong></p> <p>A. Schematic diagram of Apc1 is shown. Two loop domains (loop<sup>300</sup>, 294-399; loop<sup>500</sup>, 515-584) and PC repeat domain are shown in yellow and in cyan, respectively. Multiple alignment of sequ... | https://api.sourcedata.io/file.php?figure_id=41897 | [
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10.15252/embj.2020107516 | Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop | 2021 | Figure 2 | <sd-panel> <p><strong>Figure 2. Plx1 bound Apc1 promotes APC/C-Cdc20 complex formation.</strong></p> <p>A. Cdc20 binding assay in <em>Xenopus</em> egg extracts. The purified recombinant WT or Apc-loop<sup>500</sup> mutant APC/Cs with mutations (1-T532A, 1-T539A, 1-T532A/T539A (1-2A) and 1-S558A) was incubated with APC/... | https://api.sourcedata.io/file.php?figure_id=41899 | [
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10.15252/embj.2020107516 | Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop | 2021 | Figure 3 | <sd-panel> <p><strong>Figure 3. Interplay between Plx1 and PP2A-B56 on Apc1-loop<sup>500</sup>.</strong></p> <p>A. Apc1-loop<sup>500</sup> is the hub for both Plx1 and PP2A-B56 phosphatase. CDK sites (T or S) and B56-binding site (green) on Apc1-loop<sup>500</sup> (yellow bar) are shown. Bindings of Plx1 and B56 to Apc... | https://api.sourcedata.io/file.php?figure_id=41901 | [
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10.15252/embj.2020107516 | Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop | 2021 | Figure 4 | <sd-panel> <p><strong>Figure 4. Mutual regulation of Plx1 and PP2A-B56 on Apc1-loop<sup>500</sup>.</strong></p> <p>A. Plx1 and PP2A-B56 competes for Apc1-loop<sup>500</sup>. MBP-fused Apc1-loop<sup>500</sup> WT or its derivatives (∆11, deletion of 11 residues including the B56-binding motif) was incubated with the <sup... | https://api.sourcedata.io/file.php?figure_id=41903 | [
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10.15252/embj.2020107516 | Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop | 2021 | Figure 5 | <sd-panel> <p><strong>Figure 5. Phosphorylation and function of Apc1-loop<sup>500</sup> in <em>Xenopus</em> egg extracts.</strong></p> <p>A. Phosphorylation kinetics of T532, T539 and S558 on Apc1-loop<sup>500</sup> in anaphase extracts. MBP-fused Apc1-loop<sup>500</sup> WT or its derivatives (∆11, deletion of 11 resid... | https://api.sourcedata.io/file.php?figure_id=41905 | [
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10.15252/embj.2020107516 | Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop | 2021 | Figure 6 | <sd-panel> <p><strong>Figure 6. Increased Plx1 binding to Apc1-loop<sup>500</sup> induces premature APC/C activation</strong></p> <p><strong>and delays dephosphorylation of APC/C during mitotic exit.</strong></p> <p>A. Cdc20 binding assay in <em>Xenopus</em> egg extracts. The Cdc20-binding activities of WT APC/C and Ap... | https://api.sourcedata.io/file.php?figure_id=41907 | [
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... | ||
10.15252/embj.2020107516 | Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop | 2021 | Figure 7 | <sd-panel> <p><strong>Figure 7. A model: Plx1 and PP2A-B56 creates feedback-loop.</strong></p> <p>A. The mutations in CDK sites on Apc3-loop reduces phosphorylation of T532 on Apc1. The purified recombinant WT or a mutant APC/C with mutations at nine CDK sites in Apc3-loop (3-9A) was incubated with APC/C-depleted (ΔAPC... | https://api.sourcedata.io/file.php?figure_id=41908 | [
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10.15252/emmm.201910469 | 3,4-Dimethoxychalcone induces autophagy through activation of transcription factors TFE3 and TFEB | 2019 | Figure 1 | <sd-panel> <p><strong>Figure 1.</strong> Identification of 3,4-Dimethoxychalcone (3,4-DC) as a potential caloric restriction mimetic (CRM). (<strong>A</strong>) Human osteosarcoma U2OS GFP-LC3 cells were treated with a library of polyphenols and polyamines for 6 h (compounds are listed in <strong>Appendix Tab. S1</stro... | https://api.sourcedata.io/file.php?figure_id=28366 | [
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10.15252/emmm.201910469 | 3,4-Dimethoxychalcone induces autophagy through activation of transcription factors TFE3 and TFEB | 2019 | Figure 2 | <sd-panel> <p><strong>Figure 2.</strong> 3,4-DC induced autophagic flux. (<strong>A-D</strong>) Hepatoma HepG2 cells were treated with the indicated concentrations of 3,4-DC for 8 h <strong>(A,B)</strong> or with 30 µM 3,4-DC for the indicated time points <strong>(C,D)</strong>. Then, cells were processed to measure LC... | https://api.sourcedata.io/file.php?figure_id=28368 | [
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10.15252/emmm.201910469 | 3,4-Dimethoxychalcone induces autophagy through activation of transcription factors TFE3 and TFEB | 2019 | Figure 3 | <sd-panel> <p><strong>Figure 3.</strong> 3,4-DC induces autophagy in a transcription or translation dependent mechanism. (<strong>A, B</strong>) HepG2 cells were treated for the indicated time with 30 µM 3,4-DC <strong>(A)</strong> or indicated dose of 3,4-DC for 8 h <strong>(B)</strong>. Thereafter, cells were collect... | https://api.sourcedata.io/file.php?figure_id=28372 | [
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10.15252/emmm.201910469 | 3,4-Dimethoxychalcone induces autophagy through activation of transcription factors TFE3 and TFEB | 2019 | Figure 4 | <sd-panel> <p><strong>Figure 4.</strong> 3,4-DC induced TFEB-dependent lysosomal biogenesis and autophagy. <strong>(A,B)</strong> U2OS cells stably expressing GFP-TFEB fusion protein were treated with indicated chalcones at 30 µM for 6 h. GFP intensities in nuclei and cytoplasm were measured and the ratio of GFP intens... | https://api.sourcedata.io/file.php?figure_id=28376 | [
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10.15252/emmm.201910469 | 3,4-Dimethoxychalcone induces autophagy through activation of transcription factors TFE3 and TFEB | 2019 | Figure 5 | <sd-panel> <p><strong>Figure 5</strong> 3,4-DC induced TFEB and TFE3-depdendent autophagy <strong>(A-F)</strong> U2OS-GFP-LC3 cells transfected with 3 individual siRNAs specifically targeting TFEB (siTFEB-#1, siTFEB-#2, siTFEB-#3) or scrambled siRNA (siCtr) <strong>(A-C)</strong>, or U2OS wild type (wt) and TFEB knocko... | https://api.sourcedata.io/file.php?figure_id=28381 | [
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... | ||
10.15252/emmm.201910469 | 3,4-Dimethoxychalcone induces autophagy through activation of transcription factors TFE3 and TFEB | 2019 | Figure 6 | <sd-panel> <p><strong>Figure 6</strong>. 3,4-DC induces autophagy in vivo. (<strong>A-D</strong>) Female C57/BL6 animals were treated with 3,4-DC for 24 h. Following, liver and heart tissue was excised and cells were subjected to subcellular fractionation. Thereafter proteins were separated by SDS PAGE and immunoblots ... | https://api.sourcedata.io/file.php?figure_id=28384 | [
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10.15252/emmm.201910469 | 3,4-Dimethoxychalcone induces autophagy through activation of transcription factors TFE3 and TFEB | 2019 | Figure 7 | <sd-panel> <p><strong>Figure 7</strong>. 3,4-DC confers autophagy-dependent cardio-protection from ischemic injury. (<strong>A</strong>) Twelve weeks-old wild-type and cardiac specific Atg7 knockout (Atg7cKO) mice were injected with corn oil (vehicle control, Ctr) or 3,4-DC 24 h before surgery and subjected to 3 h prol... | https://api.sourcedata.io/file.php?figure_id=28385 | [
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10.15252/emmm.201910469 | 3,4-Dimethoxychalcone induces autophagy through activation of transcription factors TFE3 and TFEB | 2019 | Figure 8 | <sd-panel> <p><strong>Figure 8</strong>. 3,4-DC improves the efficacy of anticancer chemotherapy. <strong>A.</strong> Induction of autophagy in murine MCA205 fibrosarcomas. Cells were treated with 3,4 DC alone or in combination with chloroquine, and were harvested 6 hours later for immunoblot detection of LC3 lipidatio... | https://api.sourcedata.io/file.php?figure_id=28386 | [
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10.15252/embj.2019101928 | UV-B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development | 2019 | Figure 1 | <sd-panel> <p><strong>Figure 1. UV-B inhibits the growth of lateral roots in a UVR8-dependent manner.</strong></p> <p>A-C. Phenotypic analysis. Wild-type, <em>uvr8</em>, and <em>rup1 rup2 seedlings</em> were grown in 1/2 MS with or without UV-B (1 W/m<sup>2</sup>) for 2 weeks. Images are shown in (A); scale bars = 5 mm... | https://api.sourcedata.io/file.php?figure_id=28525 | [
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10.15252/embj.2019101928 | UV-B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development | 2019 | Figure 2 | <sd-panel> <p><strong>Figure 2. UV-B inhibits auxin responses through UVR8.</strong></p> <p>A and B. <strong>Phenotypic analysis.</strong> Seedlings of the indicated genotypes were grown in 1/2 MS with the addition of a series of concentrations of NAA under continuous white light or white plus UV-B (1 W/m<sup>2</sup>) ... | https://api.sourcedata.io/file.php?figure_id=28526 | [
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10.15252/embj.2019101928 | UV-B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development | 2019 | Figure 3 | <sd-panel> <p><strong>Figure 3. Monomeric UVR8 inhibits auxin responses in a tissue-autonomic manner.</strong></p> <p><strong>A</strong>-<strong>C.</strong> Phenotypic analysis. WT, GR-UVR8<sup>R338A</sup>/<em>uvr8</em> and GR-UVR8<sup>W285F</sup>/<em>uvr8</em> seedlings were grown in LD (16-h light/ 8-h dark) for 5 da... | https://api.sourcedata.io/file.php?figure_id=28528 | [
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10.15252/embj.2019101928 | UV-B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development | 2019 | Figure 4 | <sd-panel> <p><strong>Figure 4. UV-B represses the expression of auxin signaling genes.</strong></p> <p><strong>A and B.</strong> Transcriptome analysis of gene expression regulated by auxin, UV-B, and UVR8. (A) Heat map of UV-B-, UVR8-, and auxin-regulated genes. The parameter measured by color key shows the Log-fold ... | https://api.sourcedata.io/file.php?figure_id=28530 | [
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10.15252/embj.2019101928 | UV-B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development | 2019 | Figure 5 | <sd-panel> <p><strong>Figure 5. UVR8 physically interacts with MYB73/MYB77 in a UV-B-dependent manner.</strong></p> <p><strong>A and B. I</strong>n vitro pull-down assay showing that UV-B treatment promotes the interaction between MYB73 (A) or MYB77 (B) and UVR8. The bound proteins were eluted and analyzed by probing i... | https://api.sourcedata.io/file.php?figure_id=28532 | [
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10.15252/embj.2019101928 | UV-B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development | 2019 | Figure 6 | <sd-panel> <p><strong>Figure 6. MYB73/MYB77 acts downstream of UVR8 in controlling the auxin response.</strong></p> <p><strong>A-C.</strong> Phenotypic analysis. Seedlings of the indicated genotypes were grown in LD conditions (16-h light/ 8-h dark) for 5 days, and then transplanted to new medium containing 0.4 μM NAA ... | https://api.sourcedata.io/file.php?figure_id=28534 | [
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10.15252/embj.2019101928 | UV-B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development | 2019 | Figure 7 | <sd-panel> <p><strong>Figure 7. UVR8 inhibits the DNA-binding activity of MYB73/MYB77.</strong></p> <p>A. Electrophoretic mobility-shift assay (EMSA) showing that MYB73/MYB77 binds to the MBSI motif in vitro. Cold probe was added as a competitor.</p> <p>B. EMSA showing that MYB73/MYB77 binds to the promoter of <em>IAA1... | https://api.sourcedata.io/file.php?figure_id=28535 | [
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30126924 | 10.15252/embr.201845889 | TMEM41B is a novel regulator of autophagy and lipid mobilization | 2018 | Figure 1 | <sd-panel> <p><strong>Figure 1 - Sensitized <sd-pretag id="sdPretag1351362537sme" type="geneprod" role="assayed">CRISPR</sd-pretag> screens identify <sd-pretag id="sdPretag1883383057sme" type="geneprod" role="assayed">TMEM41B</sd-pretag> as a novel regulator of autophagy.</strong></p> <p>A Schematic representation of... | https://api.sourcedata.io/file.php?figure_id=22445 | [
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30126924 | 10.15252/embr.201845889 | TMEM41B is a novel regulator of autophagy and lipid mobilization | 2018 | Figure 2 | <sd-panel> <p><strong>Figure 2 - Knockout of <sd-pretag id="sdPretag1771361546sme" type="geneprod" role="intervention">TMEM41B</sd-pretag> impairs <sd-pretag id="sdPretag882551154sme" type="subcellular" role="component">autophagosome biogenesis</sd-pretag>.</strong></p> <p>A H4 <sd-pretag id="sdPretag1805100822sme" t... | https://api.sourcedata.io/file.php?figure_id=22447 | [
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30126924 | 10.15252/embr.201845889 | TMEM41B is a novel regulator of autophagy and lipid mobilization | 2018 | Figure 3 | <sd-panel> <p><strong>Figure 3 - <sd-pretag id="sdPretag63615150sme" type="geneprod" role="intervention">TMEM41B</sd-pretag>-deficent cells display enlarged <sd-pretag id="sdPretag1279010368sme" type="subcellular" role="component">lipid droplets</sd-pretag></strong></p> <p>A H4 <sd-pretag id="sdPretag864109077sme" ty... | https://api.sourcedata.io/file.php?figure_id=22449 | [
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30126924 | 10.15252/embr.201845889 | TMEM41B is a novel regulator of autophagy and lipid mobilization | 2018 | Figure 4 | <sd-panel> <p><strong>Figure 4 - <sd-pretag id="sdPretag935237071sme" type="geneprod" role="component">TMEM41B</sd-pretag> is required for mobilization and utilization of endogenous <sd-pretag id="sdPretag473024857sme" type="molecule" role="component">fatty acids</sd-pretag>.</strong></p> <p>A H4 <sd-pretag id="sdPre... | https://api.sourcedata.io/file.php?figure_id=22451 | [
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30126924 | 10.15252/embr.201845889 | TMEM41B is a novel regulator of autophagy and lipid mobilization | 2018 | Figure 5 | <sd-panel> <p><strong>Figure 5 - <sd-pretag id="sdPretag1362554516sme" type="geneprod" role="assayed">TMEM41B</sd-pretag> localizes to the <sd-pretag id="sdPretag648702098sme" type="subcellular" role="component">ER</sd-pretag>.</strong></p> <p>A H4 <sd-pretag id="sdPretag1428059075sme" type="cell" role="component">C... | https://api.sourcedata.io/file.php?figure_id=22453 | [
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10.15252/embr.202152744 | Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-chip model | 2021 | Figure 1 | <p><strong>Fig. 1. SARS-CoV-2 infection in a human lung-on-chip model.</strong></p><p>(<strong>A</strong>-<strong>C</strong>) (<strong>A</strong>) Schematic of the LoC model for SARS-CoV-2. Maximum intensity projections show that confluent layers of alveolar epithelial cells (ATs) and endothelial cells with strong expr... | https://api.sourcedata.io/file.php?figure_id=40533 | [
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10.15252/embr.202152744 | Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-chip model | 2021 | Figure 2 | <p><strong>Fig. 2. Viral replication but lack of release of infectious virions characterizes SARS-CoV-2 infection in the LoC model</strong>.</p><p>(<strong>A</strong>, <strong>B</strong>) The kinetics of release of SARS-CoV-2 progeny was assessed from samples obtained from a wash of the apical face of the chip (<strong... | https://api.sourcedata.io/file.php?figure_id=40535 | [
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10.15252/embr.202152744 | Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-chip model | 2021 | Figure 3 | <p><strong>Fig. 3. SARS-CoV-2 infection rapidly disrupts confluency of the endothelial layer.</strong></p><p>(<strong>A-D</strong>) 3D views of representative 232 x 232 μm<sup>2</sup> (<strong>A, B</strong>) and 155 x 155 μm<sup>2</sup> (<strong>C, D</strong>) fields of view from confocal imaging of an uninfected contr... | https://api.sourcedata.io/file.php?figure_id=40537 | [
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10.15252/embr.202152744 | Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-chip model | 2021 | Figure 4 | <p><strong>Fig. 4. SARS-CoV-2 infection leads to a loss of tight junctions, generation of CD31- endothelial cell clusters and a pro-coagulatory environment.</strong></p><p>(<strong>A-D</strong>) Maximum intensity projects of 232 x 232 μm<sup>2</sup> fields of view from the AT (<strong>A</strong>, <strong>B</strong>) an... | https://api.sourcedata.io/file.php?figure_id=40539 | [
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10.15252/embr.202152744 | Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-chip model | 2021 | Figure 5 | <p><strong>Fig. 5. RNAscope analysis reveals intracellular localization and slow accumulation of intracellular viral RNA in the LoC model.</strong></p><p><strong>(A-H)</strong> 3D views of 232 x 232 μm<sup>2</sup> fields of view of the AT (<strong>A, G</strong>) and endothelial layer (<strong>B, H</strong>) from infect... | https://api.sourcedata.io/file.php?figure_id=40541 | [
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10.15252/embr.202152744 | Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-chip model | 2021 | Figure 6 | <p><strong>Fig. 6. SARS-CoV-2 infection generates a persistent pro-inflammatory response in endothelial cells.</strong></p><p>(<strong>A</strong>) Expression relative to <em>GAPDH</em> of pro-inflammatory cytokines (<em>TNFA, IL1B, IL6)</em>, interferon genes (<em>IFNB, IFNL1, IFNL3</em>) and interferon stimulating gen... | https://api.sourcedata.io/file.php?figure_id=40543 | [
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10.15252/embr.202152744 | Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-chip model | 2021 | Figure 7 | <p><strong>Fig. 7. Tocilizumab treatment reduces vascular permeability but does not prevent formation of endothelial cell clusters with reduced <em>CD31</em> expression.</strong></p><p>(<strong>A</strong>-F<strong>)</strong> Maximum intensity projections of representative 232 x 232 μm<sup>2</sup> fields of view of the ... | https://api.sourcedata.io/file.php?figure_id=40544 | [
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10.15252/embr.202153200 | Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function | 2021 | Figure 1 | <p><strong>Figure 1. Loss of Daam2 increases morphological complexity of astrocytes in the brain.</strong></p><p>A-B. Immunostaining from Daam2<sup>LacZ/+</sup> animals with Aldh1l1-EGFP reporter indicates that Daam2 (LacZ+, Red) is expressed in astrocytes (Green). (A) Daam2 expression is observed in multiple brain reg... | https://api.sourcedata.io/file.php?figure_id=43667 | [
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10.15252/embr.202153200 | Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function | 2021 | Figure 2 | <p><strong>Figure 2. Deletion of Daam2 increases intermediate filament GFAP whereas overexpression of Daam2 reduces GFAP and morphological complexity.</strong></p><p>A. Representative images of GFAP immunostaining in Daam2 cKO mice compared to controls in cortex and OB at P28. Scale bar: 20 μm.</p><p>B. Quantification ... | https://api.sourcedata.io/file.php?figure_id=43669 | [
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10.15252/embr.202153200 | Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function | 2021 | Figure 3 | <p><strong>Figure 3. Deletion of Daam2 differentially alters astrocytic calcium dynamics in the cortex and olfactory bulb.</strong></p><p>A. Schematics of astrocytic calcium imaging in cortex from ex vivo slices and representative images of spontaneous calcium signaling (green) of Daam2 cHet and cKO mice injected with ... | https://api.sourcedata.io/file.php?figure_id=43671 | [
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10.15252/embr.202153200 | Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function | 2021 | Figure 4 | <p><strong>Figure 4. Daam2 deletion in astrocytes results in differential synaptic activity in cortex and olfactory bulb.</strong></p><p>A-F. (A, D) Schematics of whole cell recording in ex vivo brain slices and representative traces of spontaneous EPSC and IPSC in neurons in cortex from Daam2 cHet (top, black) and cKO... | https://api.sourcedata.io/file.php?figure_id=43673 | [
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10.15252/embr.202153200 | Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function | 2021 | Figure 5 | <p><strong>Figure 5. Astrocyte-specific loss of Daam2 impairs olfaction behaviors.</strong></p><p>A. Astrocyte-specific Daam2 cKO mice show delays in buried food finding. N=13, 15 mice per genotype. Data is presented as mean ± SEM. Student's t-test was used, *p<0.05.</p><p>B. Illustration of odor discrimination assa... | https://api.sourcedata.io/file.php?figure_id=43675 | [
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10.15252/embr.202153200 | Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function | 2021 | Figure 7 | <p><strong>Figure 7. Slc4a4 regulates astrocyte maturation by interacting with Daam2</strong></p><p>A. Double fluorescence in situ hybridization images indicating co-labeling of Slc4a4 (green) and GLAST (red). Scale bar: 100 μm.</p><p>B. Schematics showing induction of temporally-<strong>controlled astrocyte-specific c... | https://api.sourcedata.io/file.php?figure_id=43677 | [
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30478237 | 10.15252/msb.20188371 | Deep scanning lysine metabolism in Escherichia coli | 2018 | Figure 3 | <sd-panel><p><strong>Figure 3.</strong> Transporter route of AEC resistance. <strong>A.</strong> Mapping of enrichment across the positions targeted in <em>lysP</em>. The gray regions in the gene cartoon at the bottom highlights the windows containing targeted residues, with the enrichment map shown above for increasin... | https://api.sourcedata.io/file.php?figure_id=23775 | [
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30478237 | 10.15252/msb.20188371 | Deep scanning lysine metabolism in Escherichia coli | 2018 | Figure 4 | <sd-panel><p><strong>Figure 4.</strong> Investigating the biosynthetic gene <sd-pretag id="sdPretag690008323sm" type="tissue" role="component"><em>dapF</em></sd-pretag>. <strong>A.</strong> Mapping of enrichment across the positions targeted in <em>dapF</em>. The gray regions in the gene cartoon at the bottom highligh... | https://api.sourcedata.io/file.php?figure_id=23777 | [
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30478237 | 10.15252/msb.20188371 | Deep scanning lysine metabolism in Escherichia coli | 2018 | Figure 5 | <sd-panel><p><strong>Figure 5.</strong> Investigating <sd-pretag id="sdPretag1281188787sm" type="organism" role="component">noise</sd-pretag> and real enrichment in the plasmid-barcodes. <strong>A.</strong> Mapping of enrichment across the positions targeted in <em>lysR</em>. The gray regions in the gene cartoon at th... | https://api.sourcedata.io/file.php?figure_id=23779 | [
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10.15252/embj.2020105332 | Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism | 2020 | Figure 1 | <sd-panel> <p>Figure 1. Membrane organization during tube morphogenesis.</p> <p>(A-B) Diagram of the organization of the tracheal system at the onset of terminal cell branching (A) and one hour later (B).</p> <p>(C-C''') Terminal cell expressing reporters for membrane (C), ER (C') and Golgi apparatus (C'').</p> <p>(D) ... | https://api.sourcedata.io/file.php?figure_id=33779 | [
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10.15252/embj.2020105332 | Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism | 2020 | Figure 4 | <sd-panel> <p>Figure 4. The role of endocytosis in terminal cell growth.</p> <p>(A-E) Distribution of the plasma membrane reporter PH::GFP in control cells (A-A'') and in cells where dynamin activity had been blocked using a temperature-sensitive allele of <em>dynamin</em> (<em>shibire<sup>ts</sup></em>, B, E). In (B),... | https://api.sourcedata.io/file.php?figure_id=33784 | [
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10.15252/embj.2020105332 | Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism | 2020 | Figure 5 | <sd-panel> <p>Figure 5. Effects of <sd-pretag id="sdPretag796955996sm" type="geneprod" role="component">dynamin</sd-pretag> inactivation on membrane morphology.</p> <p>(A-F) TEM tomograms and 3D reconstructions of terminal cells in <em>shibire<sup>ts</sup></em> <sd-pretag id="sdPretag984787649sm" type="organism" role... | https://api.sourcedata.io/file.php?figure_id=33786 | [
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10.15252/embj.2020105332 | Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism | 2020 | Figure 6 | <sd-panel> <p><strong>Figure 6. Effect of dynamin inactivation on the distribution of basal proteins</strong></p> <p>(A-B) Terminal cells expressing the membrane marker CD4::mIFP under <em>btl-gal4</em> and FGFR::GFP under its own promoter (from the fTRG library). (A) Time lapse imaging of a control cell. Blue arrowhea... | https://api.sourcedata.io/file.php?figure_id=33788 | [
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10.15252/embj.2020105332 | Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism | 2020 | Figure 7 | <sd-panel> <p><strong>Figure 7. Composition and distribution of endosomal compartments during terminal cell growth</strong></p> <p>(A-D) High time resolution imaging of the membrane marker CD4::mIFP expressed under <em>btl-gal4</em>. (A) Example of a large CD4 vesicle (arrowhead) rapidly moving towards the tip of the t... | https://api.sourcedata.io/file.php?figure_id=33789 | [
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10.15252/embj.2020105332 | Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism | 2020 | Figure 8 | <sd-panel> <p><strong>Figure 8. Distribution of late endosomal markers upon disruption of the endocytic pathway</strong></p> <p>(A-F) Terminal cells expressing CD4::mIFP and FYVE::GFP under <em>btl-gal4</em>. The outline of the cells was traced using the CD4::mIFP signal and is shown as a blue dashed line. (A-C) Contro... | https://api.sourcedata.io/file.php?figure_id=33790 | [
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30389724 | 10.15252/embr.201846240 | Fine Tuning of Histone Demethylase KDM6A/B Improves the Development of Nuclear Transfer Embryo | 2018 | Figure 2 | <sd-panel><p><strong>Figure. 2 The effect of ZGA on the SCNT <sd-pretag id="sdPretag1554438065sm" type="organism" role="component">embryo</sd-pretag> quality.</strong></p><p> A. Schematics of the live-cell imaging experiments. The <sd-pretag id="sdPretag489714292sm" type="organism" role="component">embryo</sd-pretag>... | https://api.sourcedata.io/file.php?figure_id=23473 | [
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30389724 | 10.15252/embr.201846240 | Fine Tuning of Histone Demethylase KDM6A/B Improves the Development of Nuclear Transfer Embryo | 2018 | Figure 3 | <sd-panel><p><strong>Figure. 3 Abnormal <sd-pretag id="sdPretag1679285289sm" type="geneprod" role="component">H3K27me3</sd-pretag> modification of <sd-pretag id="sdPretag553768157sm" type="geneprod" role="assayed">SCNT</sd-pretag> <sd-pretag id="sdPretag1149889231sm" type="organism" role="component">embryos</sd-pret... | https://api.sourcedata.io/file.php?figure_id=23474 | [
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30389724 | 10.15252/embr.201846240 | Fine Tuning of Histone Demethylase KDM6A/B Improves the Development of Nuclear Transfer Embryo | 2018 | Figure 4 | <sd-panel><p><strong>Figure. 4 Overexpression of <sd-pretag id="sdPretag1452211901sm" type="geneprod" role="intervention">KDM6A</sd-pretag> only improves the blastocyst formation rate of SCNT <sd-pretag id="sdPretag879370062sm" type="organism" role="component">embryos</sd-pretag>, but not full-term development.</stro... | https://api.sourcedata.io/file.php?figure_id=23475 | [
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30389724 | 10.15252/embr.201846240 | Fine Tuning of Histone Demethylase KDM6A/B Improves the Development of Nuclear Transfer Embryo | 2018 | Figure 5 | <sd-panel><p><strong>Figure. 5 <sd-pretag id="sdPretag1164299868sm" type="geneprod" role="intervention">KDM6B</sd-pretag> knockdown
greatly improved the preimplantation development rate of SCNT <sd-pretag id="sdPretag1681836713sm" type="organism" role="component">embryos</sd-pretag>.</strong></p><p> A. <sd-pretag id... | https://api.sourcedata.io/file.php?figure_id=23476 | [
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30389724 | 10.15252/embr.201846240 | Fine Tuning of Histone Demethylase KDM6A/B Improves the Development of Nuclear Transfer Embryo | 2018 | Figure 6 | <sd-panel><p><span id="OLE_LINK61" class="anchor"><span id="OLE_LINK62" class="anchor"></span></span><strong>Figure. 6 <sd-pretag id="sdPretag1820744322sm" type="geneprod" role="intervention">KDM6B</sd-pretag> knockdown improved the SCNT <sd-pretag id="sdPretag1119939305sm" type="organism" role="component">embryo</sd... | https://api.sourcedata.io/file.php?figure_id=23477 | [
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30389724 | 10.15252/embr.201846240 | Fine Tuning of Histone Demethylase KDM6A/B Improves the Development of Nuclear Transfer Embryo | 2018 | Figure 7 | <sd-panel><p><strong>Figure. 7 Analyses of Molecular Features of knockdown <sd-pretag id="sdPretag599772034sm" type="geneprod" role="intervention">KDM6B</sd-pretag> assisted SCNT.</strong></p><p> A. Schematic illustration of the experimental procedures.
We combined the live-<sd-pretag id="sdPretag1299115380sm" categ... | https://api.sourcedata.io/file.php?figure_id=23478 | [
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10.15252/emmm.202115608 | Functional divergence of the two Elongator subcomplexes during neurodevelopment | 2022 | Figure 3 | <sd-panel><p><strong>Figure 3. Patient-derived <sd-pretag id="sdPretag1566417620sm" type="geneprod" role="intervention"><em>ELP4/6</em></sd-pretag> mutations inhibit Elongator activity despite the proper complex assembly</strong></p> <p><strong>A. Model of the <sd-pretag id="sdPretag1356577502sm" type="organism" role... | https://api.sourcedata.io/file.php?figure_id=47985 | [
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10.15252/embj.2022112039 | Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability | 2023 | Figure 1 | <p><strong>Figure 1．<em>CircBtnl1</em> is highly expressed in intestinal stem cells.</strong></p><p><strong>(A)</strong> A heatmap of circRNAs from small intestine crypts of C57BL/6 mice. The top eight highly expressed circRNAs (<em>circOgdh, circRasa2a, circBtnl1, circMed13I, circVapa, circSlc43a2, circCnot6I, circAlg... | https://api.sourcedata.io/file.php?figure_id=52332 | [
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10.15252/embj.2022112039 | Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability | 2023 | Figure 2 | <p><strong>Figure 2．Deletion of <em>circBtnl1</em> promotes the self-renewal of ISCs.</strong></p><p><strong>(A)</strong> Small intestine images of <em>circBtnl1</em><sup>+/+</sup> and <em>circBtnl1</em><sup>-/-</sup>mice. n = 3 mice were used for SI detection. Small intestine length are shown as means ± SD. **<em>P</e... | https://api.sourcedata.io/file.php?figure_id=52333 | [
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10.15252/embj.2022112039 | Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability | 2023 | Figure 3 | <p><strong>Figure 3．<em>CircBtnl1</em> binds Ddx3y in ISCs.</strong></p><p><strong>(A)</strong> Small intestine crypts from WT mice were lysed and incubated with biotin-labeled and linearized sense (<em>circBtnl1</em> transcripts), anti-sense, or Sepharose 4B beads control. Eluted fractions were resolved by SDS-PAGE fo... | https://api.sourcedata.io/file.php?figure_id=52334 | [
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10.15252/embj.2022112039 | Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability | 2023 | Figure 4 | <p><strong>Figure 4．<em>CircBtnl1</em> inhibits <em>Atf4</em> expression through facilitation of its mRNA stability.</strong></p><p><strong>(A)</strong> Volcano plot analysis of differentially expressed stem factors from <em>circBtnl1</em><sup>+/+</sup> and <em>circBtnl1</em><sup>-/-</sup> mice ISCs. Representative gen... | https://api.sourcedata.io/file.php?figure_id=52335 | [
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10.15252/embj.2022112039 | Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability | 2023 | Figure 5 | <p><strong>Figure 5．<em>CircBtnl1</em> deficiency promotes ATF4 onto <em>Sox9</em> promoter to trigger its expression.</strong></p><p><strong>(A)</strong> Putative ATF4-binding motifs are predicted in the mouse <em>Sox9</em> promoter (up) by Homer assay. ATF4-binding motif CACAATGCCCC were shown in mouse and human <em>... | https://api.sourcedata.io/file.php?figure_id=52336 | [
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10.15252/embj.2022112039 | Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability | 2023 | Figure 6 | <p><strong>Figure 6．Sox9-mediated signaling is required for ISC maintenance.</strong></p><p><strong>(A)</strong> Immunoblotting analysis of Sox9 and Olfm4 (stem cell maker) in small intestine crypts from <em>circBtnl1</em><sup>+/+</sup>; sg<em>Sox9</em> and <em>circBtnl1</em><sup>-/-</sup>; sg<em>Sox9</em> mice, vector... | https://api.sourcedata.io/file.php?figure_id=52337 | [
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10.15252/emmm.201911227 | Enhancing protective microglia activities with a dual function TREM2 antibody to the stalk region | 2020 | Figure 1 | <sd-panel> <p><strong>Figure 1. Screening and molecular characterization of anti-mouse TREM2 antibodies</strong></p> <p>(A) Schematic representation of TREM2 processing by ADAM10/17. Cleavage occurs C-terminal of residue His157. The entire ectodomain (residues 19-171) was used for immunization of rats to generate TREM2... | https://api.sourcedata.io/file.php?figure_id=30435 | [
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10.15252/emmm.201911227 | Enhancing protective microglia activities with a dual function TREM2 antibody to the stalk region | 2020 | Figure 2 | <sd-panel> <p><strong>Figure 2. 4D9 antibody stimulates TREM2-dependent SYK signaling and blocks ADAM17-mediated TREM2 shedding</strong></p> <p>(A) Flow cytometry dose response curve for cell binding of 4D9 mAb (EC50= 0.29nM), 4D9 Fab (EC50=0.17nM), and isotype to HEK cells stably overexpressing mouse TREM2. Data repre... | https://api.sourcedata.io/file.php?figure_id=30436 | [
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10.15252/emmm.201911227 | Enhancing protective microglia activities with a dual function TREM2 antibody to the stalk region | 2020 | Figure 3 | <sd-panel> <p><strong>Figure 3. 4D9 antibody modulates TREM2 expression in macrophages and stimulates survival</strong></p> <p>(A) Flow cytometry detection of cell surface binding of 4D9 (blue) and isotype (green) to wild type and <em>Trem2<sup>-/-</sup></em> mouse bone marrow derived macrophages. Representative histog... | https://api.sourcedata.io/file.php?figure_id=30437 | [
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10.15252/emmm.201911227 | Enhancing protective microglia activities with a dual function TREM2 antibody to the stalk region | 2020 | Figure 4 | <sd-panel> <p><strong>Figure 4. 4D9 antibody promotes myelin and Aβ(1-42) phagocytosis in primary microglia</strong></p> <p>(A) Flow cytometry detection of cell surface 4D9 (red) binding and isotype control (blue) on primary wild type and <em>Trem2<sup>-/-</sup></em> mouse microglia. Data are shown as MFI (mean fluores... | https://api.sourcedata.io/file.php?figure_id=30438 | [
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10.15252/emmm.201911227 | Enhancing protective microglia activities with a dual function TREM2 antibody to the stalk region | 2020 | Figure 5 | <sd-panel> <p><strong>Figure 5. Pharmacokinetics and <em>In vivo</em> target engagement with 4D9 antibody</strong></p> <p>(A) 4D9 demonstrates standard IgG pharmacokinetics <em>in vivo</em>. Peripheral clearance rates of 4D9 on a human IgG effectorless backbone compared to an isotype control were determined in wild typ... | https://api.sourcedata.io/file.php?figure_id=30439 | [
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10.15252/emmm.201911227 | Enhancing protective microglia activities with a dual function TREM2 antibody to the stalk region | 2020 | Figure 6 | <sd-panel> <p><strong>Figure 6. 4D9 antibody modulates TREM2 functions within the brain</strong></p> <p>(A) Schematic outlining study design and timeline of intraperitoneal injections of either isotype control of 4D9 antibody in 6 months old APP-NL-G-F and age-matched WT mice.</p> <p>(B) Immunohistochemical costainings... | https://api.sourcedata.io/file.php?figure_id=30440 | [
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10.15252/emmm.201911227 | Enhancing protective microglia activities with a dual function TREM2 antibody to the stalk region | 2020 | Figure 7 | <sd-panel> <p><strong>Figure 7. 4D9 antibody reduces plaque burden</strong></p> <p>(A, B) Overview of the cortex immunohistochemically stained for Aβ plaques in 6 months old APP-NL-G-F mice treated with isotype control (A) and 4D9 antibody (B). Scale bar= 100µm.</p> <p>(C) Higher magnification images of cortical Aβ pla... | https://api.sourcedata.io/file.php?figure_id=30441 | [
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10.15252/emmm.202013579 | High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation | 2021 | Figure 1 | <sd-panel> <p><strong>Figure 1: Inhibition of mitochondrial division prevents mitochondrial fragmentation caused by OPA1 deficiency in DOA+ patient-derived fibroblasts</strong></p> <p><strong>(A)</strong> Schematic of supervised machine learning (ML) mitochondrial morphology imaging and quantification pipeline. Fibrobl... | https://api.sourcedata.io/file.php?figure_id=41567 | [
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10.15252/emmm.202013579 | High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation | 2021 | Figure 3 | <sd-panel> <p><strong>Figure 3: PGS1 depletion rescues mitochondrial fragmentation in OPA1-deficient human and mouse fibroblasts</strong></p> <p><strong>(A)</strong> Representative confocal images of control (CTL-1) and <em>OPA1<sup>S545R</sup></em> patient fibroblasts treated with <em>OPA1</em>, <em>DNM1L</em>, <em>PG... | https://api.sourcedata.io/file.php?figure_id=41569 | [
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10.15252/emmm.202013579 | High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation | 2021 | Figure 5 | <sd-panel> <p><strong>Figure 5: Interfering with the cardiolipin synthesis pathway can prevent mitochondrial fragmentation in Opa1 deficient fibroblasts</strong></p> <p><strong>(A)</strong> Schematic of cardiolipin (CL) biosynthesis pathway in mitochondria. Phosphatidic acid (PA) is transported to the inner membrane by... | https://api.sourcedata.io/file.php?figure_id=41571 | [
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10.15252/emmm.202013579 | High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation | 2021 | Figure 6 | <sd-panel> <p><strong>Figure 6: Pgs1 depletion does not rescue apoptotic sensitivity nor cristae structure in Opa1-deficient MEFs.</strong></p> <p><strong>(A, B)</strong> (Top) MEFs of the indicated genotypes were subjected to 4μM Actinomycin D and 10μM ABT-737 in the presence or absence of the pan-caspase inhibitor qV... | https://api.sourcedata.io/file.php?figure_id=41572 | [
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10.15252/emmm.202013579 | High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation | 2021 | Figure 7 | <sd-panel> <p><strong>Figure 7: Pgs1 depletion enhances respiration in wild type and Opa1-deficient MEFs.</strong></p> <p><strong>(A-C) (A)</strong> Mitochondrial respiration measured in adherent MEFs of the indicated genotypes using Seahorse FluxAnalyzer. Oxygen consumption rate (OCR) normalized to protein concentrati... | https://api.sourcedata.io/file.php?figure_id=41573 | [
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22535248 | 10.1038/nature10992 | Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure | 2012 | f2 | <p>Mice were analysed 2 days after TAC (<b>a–c</b>). <b>a</b>, Haematoxylin and eosin-stained heart sections. Scale bar, 100 &mgr;m. <b>b</b>, AZAN-Mallory-stained sections. Scale bar, 100 &mgr;m. <b>c</b>, Immunohistochemical analysis using antibodies to CD45, CD68, Ly6G and CD3. Scale bar, 100 &mgr;m.</p> | https://api.sourcedata.io/file.php?figure_id=2732 | [
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22535248 | 10.1038/nature10992 | Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure | 2012 | f3 | <p>Mice were analysed 2 days after TAC (<b>a–e</b>). <b>a</b>, Electron microscopic analysis. Images of mitochondria at higher magnification are shown in subsets. Scale bar, 1 &mgr;m. <b>b</b>, Autolysosome after incubation with anti-DNA antibody and 10 nm gold staining. Scale bar, 200 nm. Arrows indicate labelled DNA.... | https://api.sourcedata.io/file.php?figure_id=2733 | [
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22535248 | 10.1038/nature10992 | Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure | 2012 | f4 | <p><b>a</b>, Survival ratio of TAC-operated ODN-treated mice (<i>n</i> = 6–10 per group). <b>b–d</b>, Four days after TAC. <b>b</b>, Echocardiography. Scale bars, 0.2 s and 5 mm. <b>c</b>, Echocardiographic parameters. Open and closed bars represent ODN2088 control- and ODN2088-treated groups, respectively (<i>n</i> = ... | https://api.sourcedata.io/file.php?figure_id=2734 | [
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... | |
18454133 | 10.1038/nature07006 | Essential role for Nix in autophagic maturation of erythroid cells | 2008 | figf1 | <p><b>a</b>, Polychromasia (Wright–Giemsa stain, indicated by arrows) and increased reticulocytes (brilliant cresyl blue stain) revealed by staining blood smears from 6-week-old wild-type (WT) or <i>Nix</i><super>-/-</super> mice (scale bar, 20 &mgr;m). <b>b</b>, <b>c</b>, Ter119 (<b>b</b>) or Mitotracker deep red (<b>... | https://api.sourcedata.io/file.php?figure_id=2664 | [
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18454133 | 10.1038/nature07006 | Essential role for Nix in autophagic maturation of erythroid cells | 2008 | figf2 | <p><b>a</b>, Quantification of NHS-biotin-labelled RBCs or transferred CMFDA-labelled RBCs (<i>n</i> = 3). <b>b</b>, Western blot analyses of caspases in RBCs after <i>in vitro</i> culture. Asterisks denote processed caspases. FL, full length. <b>c</b>, The relative luminescence units (RLU) of caspase activities in cul... | https://api.sourcedata.io/file.php?figure_id=2665 | [
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"type": "geneprod",
... | |
18454133 | 10.1038/nature07006 | Essential role for Nix in autophagic maturation of erythroid cells | 2008 | figf3 | <p><b>a</b>, Ter119<super>+</super>CD71<super>+</super> reticulocytes sorted at day 3 or 6 after PHZ treatment were cultured for <i>in vitro</i> maturation for 0 (top row), 2 (middle row) or 4 (bottom row) days, followed by Mitotracker deep red and Ter119 staining. <b>b</b>, CD71<super>+</super>Ter119<super>+</super> r... | https://api.sourcedata.io/file.php?figure_id=2666 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "Q62351",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "CD71",
"type": "geneprod",
"unip... | |
18454133 | 10.1038/nature07006 | Essential role for Nix in autophagic maturation of erythroid cells | 2008 | figf4 | <p><b>a</b>, Ter119<super>+</super>CD71<super>+</super> reticulocytes were sorted from the peripheral blood of wild-type and <i>Nix</i><super>-/-</super> mice at day 6 after PHZ treatment. The cells were cultured for <i>in vitro</i> maturation in the presence of 10 &mgr;M FCCP or 1 &mgr;M ABT-737, followed by staining ... | https://api.sourcedata.io/file.php?figure_id=2667 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "12177",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "12177",
"original_type": "gene",
"role": "intervention",
"text": "Nix",
"type": "geneprod",
... | |
27737899 | 10.15252/emmm.201606434 | Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality | 2016 | Figure 1 | <p>Figure 1. Am80-GCSF alters transcription of RA-target genes that promote induction of large amounts of neutrophils with well-developed innate immunity in normal primary human hematopoietic specimens.</p>
<p>(A) Proliferation analysis of hematopoietic CD34+ precursors for up to 6 days (section i). Neutrophil morpholo... | https://api.sourcedata.io/file.php?figure_id=10150 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P09919",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "intervention",
"text": "GCSF",
"type": "geneprod",
"... | |
27737899 | 10.15252/emmm.201606434 | Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality | 2016 | Figure 3 | <p>Figure 3. Significant induction of RARβ2 and C/EBPε by Am80-GCSF are associated with both production of functional neutrophils and growth inhibition in primary human leukemic specimens.</p>
<p>(A) Fresh BM mononuclear cells collected from AML patients were treated with 20 or 50 nM Am80 alone or combined with medium ... | https://api.sourcedata.io/file.php?figure_id=10152 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P09919",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "intervention",
"text": "GCSF",
"type": "geneprod",
"... | |
27737899 | 10.15252/emmm.201606434 | Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality | 2016 | Figure 5 | <p>Figure 5. Am80-GCSF coordinates myeloid expansion with granulocytic differentiation to generate large amounts of functional neutrophils that reduce infection in CCIN mice.</p>
<p>(A) After 48 hr of CPA injection, mice were treated with low doses of Am80 and/or GCSF for 3 days. Mice were infected with 9 x 106 CFU of ... | https://api.sourcedata.io/file.php?figure_id=10154 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P09920",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "intervention",
"text": "GCSF",
"type": "geneprod",
... | |
27737899 | 10.15252/emmm.201606434 | Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality | 2016 | Figure 7 | <p>Figure 7. Am80-GCSF prevents myeloid overexpansion while generating sufficient numbers of functional neutrophils during ‘emergency’ granulopoiesis in CCIN mice.</p>
<p>(A & B) Neutrophil recovery and morphologic differentiation were assessed in BM (panel A) and PB (panel B) of CCIN mice surviving on day 9. White arr... | https://api.sourcedata.io/file.php?figure_id=10156 | [
{
"ext_dbs": "Uniprot",
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"ncbi_gene_id": null,
"original_type": "protein",
"role": "intervention",
"text": "GCSF",
"type": "geneprod",
... | |
10.15252/msb.20209530 | Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae | 2020 | Figure 2 | <sd-panel> <p><strong>Figure 2. Phenotypic characterization of Lon and FtsH conditional mutants in <em>M. pneumoniae</em>.</strong></p> <p><strong>(A).</strong> Cell growth assessment of ΔIndLon (upper plot) and ΔIndFtsH (lower plot) mutants grown under inducing (blue) or depleting conditions (red). Growth was monitore... | https://api.sourcedata.io/file.php?figure_id=37259 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "45596573",
"ext_tax_ids": "722438",
"ext_tax_names": "Mycoplasma pneumoniae FH",
"mapping_source": "unmapped",
"mapping_status": "unmapped",
"ncbi_gene_id": "45596573",
"original_type": "gene",
"role": "intervention",
"text": "FtsH",
... | ||
10.15252/msb.20209530 | Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae | 2020 | Figure 4 | <sd-panel> <p><strong>Figure 4. Validation of selected Lon and FtsH candidate substrates.</strong></p> <p><strong>(A)</strong> Transcription profiles of ΔIndLon mutants grown in inducing (+) or depleting (-) conditions across the cell division and the MPN525 (DnaB) operons. The respective estimated protein copy numbers... | https://api.sourcedata.io/file.php?figure_id=37262 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "45596210",
"ext_tax_ids": "722438",
"ext_tax_names": "Mycoplasma pneumoniae FH",
"mapping_source": "unmapped",
"mapping_status": "unmapped",
"ncbi_gene_id": "45596210",
"original_type": "gene",
"role": "intervention",
"text": "Lon",
"... | ||
10.15252/msb.20209530 | Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae | 2020 | Figure 5 | <sd-panel> <p><strong>Figure 5. Mutational analysis to identify Lon degrons in Lon substrates.</strong></p> <p><strong>(A)</strong> Amino acid sequence of the last 50 residues of FtsA (MPN316), FtsZ (MPN317) and DnaB (MPN525) proteins and their mutant derivatives. Hydrophobic motifs that can potentially act as Lon degr... | https://api.sourcedata.io/file.php?figure_id=37263 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "45596210",
"ext_tax_ids": "722438",
"ext_tax_names": "Mycoplasma pneumoniae FH",
"mapping_source": "unmapped",
"mapping_status": "unmapped",
"ncbi_gene_id": "45596210",
"original_type": "gene",
"role": "intervention",
"text": "Lon",
"... | ||
10.15252/msb.20209530 | Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae | 2020 | Figure 6 | <sd-panel> <p><strong>Figure 6. Role of Lon as a protein quality control protease.</strong></p> <p><strong>(A)</strong> Protein stability of an unstable firefly luciferase variant (Fluc_F89E) assessed by anti-Fluc antibodies in ΔIndLon mutants grown in inducing (+) or depleting (-) conditions (48h of depletion). LC, lo... | https://api.sourcedata.io/file.php?figure_id=37264 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "45596210",
"ext_tax_ids": "722438",
"ext_tax_names": "Mycoplasma pneumoniae FH",
"mapping_source": "unmapped",
"mapping_status": "unmapped",
"ncbi_gene_id": "45596210",
"original_type": "gene",
"role": "intervention",
"text": "Lon",
"... | ||
27856517 | 10.15252/embj.201694526 | mGluR-Long Term Depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum | 2016 | Figure 1 | <p><strong>Figure 1</strong><strong>. DHPG treatment reduces surface GluA1 levels, and increases surface GluA2 levels in </strong><strong>an ER Ca</strong><strong><sup>2+ </sup></strong><strong>dependent</strong><strong> manner.</strong></p>
<p>A. Labeling of non-permeabilized (top) and permeabilized (bottom) cells dem... | https://api.sourcedata.io/file.php?figure_id=10683 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P19491",
"ext_tax_ids": "10116",
"ext_tax_names": "Rattus norvegicus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "GluA2",
"type": "geneprod",
... | |
27856517 | 10.15252/embj.201694526 | mGluR-Long Term Depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum | 2016 | Figure 2 | <p><strong>Figure 2</strong><strong>.</strong> <strong>Blocking </strong><strong>Ca</strong><strong><sup>2+</sup></strong><strong> release from the ER but not extracellular Ca</strong><strong><sup>2+</sup></strong><strong> entry into the cell </strong><strong>prevents the DHPG mediated increase of surface GluA2 levels.... | https://api.sourcedata.io/file.php?figure_id=10684 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P19491",
"ext_tax_ids": "10116",
"ext_tax_names": "Rattus norvegicus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "GluA2",
"type": "geneprod",
... | |
27856517 | 10.15252/embj.201694526 | mGluR-Long Term Depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum | 2016 | Figure 3 | <p><strong>Figure 3</strong><strong>. DHPG regulates GluA2, but not GluA1, exit from the ER in an ER </strong><strong>Ca</strong><strong><sup>2+</sup></strong><strong> dependent manner.</strong></p>
<p>A. Top. Representative image of a radiograph of mature and immature bands of GluA2 after no treatment, DHPG, or 2APB/d... | https://api.sourcedata.io/file.php?figure_id=10685 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P19491",
"ext_tax_ids": "10116",
"ext_tax_names": "Rattus norvegicus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "GluA2",
"type": "geneprod",
... | |
27856517 | 10.15252/embj.201694526 | mGluR-Long Term Depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum | 2016 | Figure 4 | <p><strong>Figure 4</strong><strong>. DHPG drives increased association between GluA2 and the COPII vesicle protein, Sec23.</strong></p>
<p>A Top. Representative immunoblots from GluA2 coimmunoprecipitations probed for Sec23 and GluA2 after no treatment, 10 min DHPG, and 2APB/dantrolene followed by 10 min DHPG. Bottom.... | https://api.sourcedata.io/file.php?figure_id=10686 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P19491",
"ext_tax_ids": "10116",
"ext_tax_names": "Rattus norvegicus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "GluA2",
"type": "geneprod",
... | |
27856517 | 10.15252/embj.201694526 | mGluR-Long Term Depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum | 2016 | Figure 5 | <p><strong>Figure 5</strong><strong>. The kinetics of GluA2 association with Sec23 after DHPG treatment. </strong></p><p>A. Representative immunoblots from GluA2 coIP probed for Sec23, Sec13, and GluA2 after no DHPG, 10, 30, and 60 minutes of treatment with DHPG. B. Graph depicting the kinetics of the association betwe... | https://api.sourcedata.io/file.php?figure_id=10687 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P19491",
"ext_tax_ids": "10116",
"ext_tax_names": "Rattus norvegicus",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "GluA2",
"type": "geneprod",
... | |
29150433 | 10.15252/embj.201796484 | [BioStudies]_Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly | 2017 | Figure 1 | <sd-panel> <p><strong>Figure 1. <sd-pretag parent-gene-tag-id='8' parent-protein-tag-id='13' id='sdPretag1751568128sd'>Src</sd-pretag>-family kinases target <sd-pretag parent-gene-tag-id='63' parent-protein-tag-id='3' id='sdPretag1408515948sd'>Munc18-1</sd-pretag> on Y473</strong></p> <p>(A) Using denaturing <sd-pretag... | https://api.sourcedata.io/file.php?figure_id=16691 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "6714",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "6714",
"original_type": "gene",
"role": "intervention",
"text": "Src",
"type": "geneprod",
... | |
29150433 | 10.15252/embj.201796484 | [BioStudies]_Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly | 2017 | Figure 2 | <sd-panel> <p><strong>Figure 2. <sd-pretag parent-tag-id='11' id='sdPretag173213950sd'>Tyrosine phosphorylation</sd-pretag> of <sd-pretag parent-gene-tag-id='63' parent-protein-tag-id='3' id='sdPretag543287214sd'>Munc18-1</sd-pretag> disrupts basal <sd-pretag parent-tag-id='62' id='sdPretag1954765576sd'>synaptic transm... | https://api.sourcedata.io/file.php?figure_id=16692 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "20910",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "20910",
"original_type": "gene",
"role": "intervention",
"text": "munc18-1",
"type": "genepro... | |
29150433 | 10.15252/embj.201796484 | [BioStudies]_Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly | 2017 | Figure 3 | <sd-panel> <p><strong>Figure 3. <sd-pretag parent-tag-id='224' id='sdPretag41177920sd'>Docked</sd-pretag> <sd-pretag parent-tag-id='665' id='sdPretag568158632sd'>synaptic vesicles</sd-pretag> are halted in a pre-primed state.</strong></p> <p><sd-pretag parent-tag-id='60' id='sdPretag841756424sd'>Neurons</sd-pretag> exp... | https://api.sourcedata.io/file.php?figure_id=16693 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "20910",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "20910",
"original_type": "gene",
"role": "intervention",
"text": "munc18-1",
"type": "genepro... | |
29150433 | 10.15252/embj.201796484 | [BioStudies]_Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly | 2017 | Figure 4 | <sd-panel> <p><strong>Figure 4. <sd-pretag parent-tag-id='62' id='sdPretag1202486193sd'>Synaptic transmission</sd-pretag> is partly restored during sustained stimulation.</strong></p> <p><sd-pretag parent-tag-id='62' id='sdPretag1163845986sd'>Synaptic transmission</sd-pretag> was assessed during and immediately after s... | https://api.sourcedata.io/file.php?figure_id=16694 | [
{
"ext_dbs": "NCBI gene",
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"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "20910",
"original_type": "gene",
"role": "intervention",
"text": "munc18-1",
"type": "genepro... |
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