pmid stringlengths 2 8 | title stringlengths 21 1.13k | abstract stringlengths 128 6k | doi stringlengths 0 72 |
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32707081 | Pregnancy-induced adaptation of central sensitivity to leptin and insulin. | Pregnancy is a time of increased food intake and fat deposition in the mother, and adaptations of glucose homeostasis to meet the energy demands of the growing fetus. As part of these adaptations, leptin and insulin concentrations increase in the maternal circulation during pregnancy. Central effects of leptin and insu... | 10.1016/j.mce.2020.110933 |
6829994 | Improved emergency department patient flow: five years of experience with a scribe system. | Alternative methods for rapidly producing accurate medical records, usually dictation-transcription systems or nurse-scribe methods, have been used in emergency departments. We now have more than five years of experience with a non-nurse scribe system. This system has proven effective in generating accurate and complet... | 10.1016/s0196-0644(83)80559-9 |
10501459 | Dopamine D1/D2 agonists injected into nucleus accumbens and ventral pallidum differentially affect locomotor activity depending on site. | Ventral pallidal dopamine has been recently shown to play an important role in psychostimulant reward and locomotor activation. The aim of the present study was to compare the roles of ventral pallidal D1 and D2 receptors in evoking locomotor activity with those in the nucleus accumbens. The D1 agonist SKF 38393 and th... | 10.1016/s0306-4522(99)00235-3 |
26398249 | Q Fever Outbreak among Workers at a Waste-Sorting Plant. | An outbreak of Q fever occurred in February-April 2014 among workers at a waste-sorting plant in Bilbao (Spain). The outbreak affected 58.5% of investigated employees, 47.2% as confirmed cases (PCR and/or serology) and 11.3% as probable cases (symptoms without laboratory confirmation). Only employees who had no-access ... | 10.1371/journal.pone.0138817 |
12629158 | Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice. | necdin (Ndn) is one of a cluster of genes deleted in the neurodevelopmental disorder Prader-Willi syndrome. necdin is upregulated during neuronal differentiation and is thought to play a role in cell cycle arrest in terminally differentiated neurons. Most necdin-deficient Ndn(tm2Stw) mutant pups carrying a targeted rep... | |
33756012 | Factors related to the uncontrolled fasting blood sugar among type 2 diabetic patients attending primary health care center, Abha city, Saudi Arabia. | To identify risk factors related to uncontrolled fasting blood sugar among type 2 diabetic patients. A systematic random sampling technique was followed to include 450 diabetic patients attending Al-Qabil Primary Health Care Center in Abha City, Saudi Arabia. Collected data comprised sociodemographic characteristics (a... | 10.1111/ijcp.14168 |
32739455 | Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis. | Exposure to nonbiodegradable cadmium (Cd) causes many health problems including the damage to the nervous system. This study aimed to increase knowledge about its neurotoxic effects and the neuroprotective potential of caffeic acid phenethyl ester (CAPE, a polyphenol abundant in honeybee propolis). In mice, CAPE (10 μm... | 10.1016/j.fct.2020.111636 |
10188633 | Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites. | The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus that responds strongly to exposure to various stressors. Many of the projection targets of PVT neurons, including the medial prefrontal cortex, nucleus accumbens, and central/basolateral nuclei of the amygdala, are also activated by stress.... | 10.1002/(SICI)1098-2396(199904)32:1<13::AID-SYN2>3.0.CO;2-R |
16906494 | Fourier transform near-infrared vibrational circular dichroism used for on-line monitoring the epimerization of 2,2-dimethyl-1,3-dioxolane-4-methanol: A pseudo racemization reaction. | Near-infrared (near-IR) Fourier transform vibrational circular dichroism (FT-VCD) spectroscopy has been used to monitor the epimerization of (S)-(+)-2,2-dimethyl-1,3-dioxolane-4-methanol (S-DDM). The near-IR-VCD spectra display clear isolated VCD bands at the range of 4700-5050 cm(-1) resulting from the OH stretch-bend... | 10.1002/chir.20263 |
21299903 | Molecular identification and transmission studies of X-cell parasites from Atlantic cod Gadus morhua (Gadiformes: Gadidae) and the northern black flounder Pseudopleuronectes obscurus (Pleuronectiformes: Pleuronectidae). | Epidermal pseudotumours from Hippoglossoides dubius and Acanthogobius flavimanus in Japan and gill lesions in Limanda limanda from the UK have been shown to be caused by phylogenetically related protozoan parasites, known collectively as X-cells. However, the phylogenetic position of the X-cell group is not well suppor... | 10.1186/1756-3305-4-15 |
11606548 | DNA dinucleotide evolution in humans: fitting theory to facts. | We examine length distributions of approximately 6000 human dinucleotide microsatellite loci, representing chromosomes 1-22, from the GDB database. Under the stepwise mutation model, results from theory and simulation are compared with the empirical data. In both constant and expanding population scenarios, a simple si... | 10.1093/genetics/159.2.737 |
38878375 | Composite superplastic aerogel scaffolds containing dopamine and bioactive glass-based fibers for skin and bone tissue regeneration. | Multifunctional bioactive biomaterials with integrated bone and soft tissue regenerability hold great promise for the regeneration of trauma-affected skin and bone defects. The aim of this research was to fabricate aerogel scaffolds (GD-BF) by blending the appropriate proportions of short bioactive glass fiber (BGF), g... | 10.1016/j.jcis.2024.06.098 |
8389935 | Characterization of the regulatory functions of varicella-zoster virus open reading frame 4 gene product. | Varicella-zoster virus (VZV) open reading frame 4 (ORF4) encodes a protein with a predicted molecular weight of 51,540 presenting amino acid sequence homology with the immediate-early regulatory protein ICP27 of herpes simplex virus type 1. To investigate the regulatory properties of the ORF4 gene product, we performed... | 10.1128/JVI.67.7.4379-4385.1993 |
39513442 | A computer simulation study of a chiral active ring polymer. | We investigate a ring polymer under the influence of chiral active Brownian forces in two dimensions using coarse-grained computer simulations. We observe a non-monotonic behavior of the radius of gyration of an active Brownian ring as a function of active force. However, the shrinkage of the ring in the intermediate s... | 10.1063/5.0232538 |
28720239 | Effect of diet and exercise intervention in Chinese pregnant women on gestational weight gain and perinatal outcomes: A quasi-experimental study. | Aim To determine the effect of a diet and exercise intervention in pregnant women on total gestational weight gain, weekly weight gain, 42-days postpartum weight retention, mode of delivery, and infant birth weight. One hundred and one eligible Chinese pregnant women whose pre-pregnancy body mass index ranged from 18.5... | 10.1016/j.apnr.2017.05.001 |
27073040 | The Risk of Hospital Admission Due to Traumatic Brain Injury Is Increased in Older Persons With Severe Functional Limitations. | Hospital admissions due to traumatic brain injuries (TBIs) in older persons are increasing. Falls are the leading mechanism of injury in this age group. TBIs are associated with unfavorable outcomes such as mortality and institutionalization. To estimate rates of TBIs in older persons with severe functional limitations... | 10.1016/j.jamda.2016.02.032 |
512694 | Central conduction time as an index of ischaemia in subarachnoid haemorrhage. | Central conduction time (CCT) has been measured in 12 healthy volunteers, and in 16 patients admitted to a neurosurgical unit following subarachnoid haemorrhage. Twelve of the patients were subsequently operated upon for the obliteration of an intracranial aneurysm. CCT has been found to have low standard deviation in ... | 10.1016/0022-510x(79)90227-2 |
17638927 | Residential exposure to traffic is associated with coronary atherosclerosis. | Long-term exposure to fine-particulate-matter (PM2.5) air pollution may accelerate the development and progression of atherosclerosis. We investigated the associations of long-term residential exposure to traffic and fine particulate matter with the degree of coronary atherosclerosis. We used baseline data on 4494 part... | 10.1161/CIRCULATIONAHA.107.693622 |
16437896 | [Intrahepatic cholangiocarcinoma: case report]. | The primitive tumors of the liver are relatively rare in the Western countries (around the 0.7% of all the neoplasms) while they present more elevated incidence in Africa and in the South Asian East. While the hepatocellular carcinoma rises up in the 50-70% of the cases in livers cirrosis, this correlation is not valid... | |
10551409 | Cutaneous involvement in lymphoblastic lymphoma. | Lymphoblastic leukemia/lymphoma (LBL) is a malignant neoplasm of precursor lymphocytes of B- or T-cell phenotype. Involvement of the skin is relatively uncommon. We examined retrospectively the clinicopathologic, immunophenotypic, and molecular genetic features of six patients with cutaneous involvement of LBL (B-LBL=5... | 10.1111/j.1600-0560.1999.tb01861.x |
17216731 | [The significance of Bernard Brouwer's contribution to Dutch neurology and neurosurgery. On the 125th anniversary of the year of his birth]. | Following his training under Winkler and carrying out research at the Central Institute for Brain Research in Amsterdam, in 1923 Bernard Brouwer (1881-1949) became the firstprofessor ofneurologyindependent from psychiatry, in the Netherlands. His most important scientific work included comparative anatomical studies of... | |
22465140 | [Mechanisms of action of high-frequency deep brain stimulation. A review of the literature and current concepts]. | High-frequency deep brain stimulation (HF-DBS) has become a widely used therapeutic method in the field of movement disorders for the treatment of Parkinson's disease, essential tremor or dystonia. New targets and indications are under evaluation in several other conditions such as cluster headache, obesity, epilepsy o... | 10.1016/j.neuchi.2012.02.006 |
33113247 | Comparative analyses of transgene expression patterns after intra-striatal injections of rAAV2-retro in rats and rhesus monkeys: A light and electron microscopic study. | Retrogradely-transducing viral vectors are versatile tools for anatomical and functional interrogations of neural circuits. These vectors can be applied in nonhuman primates (NHPs), powerful model species for neuroscientific studies with limited genetic tractability, but limited data are available regarding the tropism... | 10.1111/ejn.15027 |
24250429 | The Incidence of Amikacin Ototoxicity in Multidrug-ResistantTuberculosis Patients. | Amikacin has been shown to irreversibly suppressCochlear activity. The aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity. In this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (MDR-TB... | |
36013731 | Isothermal Quenching of As-Cast Medium Carbon, High-Silicon AR Steel. | Medium carbon high-silicon abrasion resistant (AR) steel was examined by performing dilatometry, light optical microscopy (LOM), scanning electron microscopy (SEM), and hardness measurements after isothermal bainitization and modified martempering and compared to direct quenching technology. A commercial thermodynamic ... | 10.3390/ma15165595 |
2489050 | Preferential usage of JH2 in D-J joinings with DQ52 in murine lymphocytes. | Southern blot analysis of genomic DNA of normal mouse thymocytes with a JH4 probe, a probe for JH4 of Igh genes, consistently showed a second band in addition to a germline band. The same band was also observed in analysis with a 5' DQ probe, a 5'-flanking sequence of DQ52, thus suggesting the use of DQ52. By analyzing... | 10.1093/intimm/1.6.643 |
35260608 | HIDTI: integration of heterogeneous information to predict drug-target interactions. | Identification of drug-target interactions (DTIs) plays a crucial role in drug development. Traditional laboratory-based DTI discovery is generally costly and time-consuming. Therefore, computational approaches have been developed to predict interactions between drug candidates and disease-causing proteins. We designed... | 10.1038/s41598-022-07608-3 |
28264154 | Deep-Learning-Based Drug-Target Interaction Prediction. | Identifying interactions between known drugs and targets is a major challenge in drug repositioning. In silico prediction of drug-target interaction (DTI) can speed up the expensive and time-consuming experimental work by providing the most potent DTIs. In silico prediction of DTI can also provide insights about the po... | 10.1021/acs.jproteome.6b00618 |
18207708 | Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex. | A mechanistic model is proposed to predict the time course of the concentrations of 5-HT and its metabolite 5-hydroxyindolacetic acid (5-HIAA) in rat frontal cortex following acute administration of SSRIs. In the model, SSRIs increase synaptic 5-HT concentrations by reversible blockade of the SERT in a direct concentra... | 10.1016/j.ejps.2007.12.001 |
19114019 | The effect of time-to-surgery on outcome in elderly patients with proximal femoral fractures. | Whether reducing time-to-surgery for elderly patients suffering from hip fracture results in better outcomes remains subject to controversial debates. As part of a prospective observational study conducted between January 2002 and September 2003 on hip-fracture patients from 268 acute-care hospitals all over Germany, w... | 10.1186/1471-2474-9-171 |
9506965 | Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology. | The human estrogen receptor (ER) contains two major activation functions (AFs) responsible for its transcriptional activity. One of these, activation function 2 (AF-2), located within the hormone-binding domain (HBD), has been shown to mediate the ligand-dependent transcriptional activity of ER as well as other members... | 10.1074/jbc.273.12.6679 |
21740203 | Nursing home admissions and long-stay conversions among persons with and without serious mental illness. | The appropriateness of nursing homes for individuals with serious mental illness remains a controversial issue in long-term care policy more than a decade since the landmark U. S. Supreme Court Olmstead decision in 1999, which affirmed the rights of persons with disabilities to live in their communities. Using national... | 10.1080/08959420.2011.579511 |
19633988 | Aromatic plants in nests of the blue tit Cyanistes caeruleus protect chicks from bacteria. | Several bird species add fresh fragments of plants which are rich in volatile secondary compounds to their nests. It has been suggested, although never tested, that birds use fresh plants to limit the growth of nest microorganisms. On Corsica, blue tits (Cyanistes caeruleus) incorporate fresh fragments of aromatic plan... | 10.1007/s00442-009-1418-6 |
31442552 | Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells. | Breast cancer (BCa) is the most commonly diagnosed lethal cancer in women worldwide. Notch signaling pathway is directly linked to BCa recurrence and aggressiveness. Natural remedies are becoming a prime choice to overcome against cancer due to lesser side effect and cost-effectiveness. Bulbine frutescens (Asphodelacea... | 10.1016/j.lfs.2019.116783 |
35922553 | Integrative phosphatidylcholine metabolism through phospholipase A 2 in rats with chronic kidney disease. | Dysregulation in lipid metabolism is the leading cause of chronic kidney disease (CKD) and also the important risk factors for high morbidity and mortality. Although lipid abnormalities were identified in CKD, integral metabolic pathways for specific individual lipid species remain to be clarified. We conducted ultra-h... | 10.1038/s41401-022-00947-x |
33289263 | Three questions about the eco-physiology of overwintering underground. | In cold environments ectotherms can be dormant underground for long periods. In 1941 Cowles proposed an ecological trade-off involving the depth at which ectotherms overwintered: on warm days, only shallow reptiles could detect warming soils and become active; but on cold days, they risked freezing. Cowles discovered t... | 10.1111/ele.13636 |
10584001 | The hemolytic enterotoxin HBL is broadly distributed among species of the Bacillus cereus group. | The prevalence of the hemolytic enterotoxin complex HBL was determined in all species of the Bacillus cereus group with the exception of Bacillus anthracis. hblA, encoding the binding subunit B, was detected by PCR and Southern analysis and was confirmed by partial sequencing of 18 strains. The sequences formed two clu... | 10.1128/AEM.65.12.5436-5442.1999 |
12553306 | Human immunodeficiency virus type 1 RNA polymerase chain reaction reasonably excludes infection in exposed infants. | A nucleic acid sequence-based amplification (NASBA) assay that detects HIV RNA may be helpful in excluding perinatal HIV infection. We reviewed the records of 190 infants born to HIV-infected mothers. The sensitivity and specificity of the NASBA assay were 100% when measured at two time periods in the first 9 months of... | 10.1097/00006454-200301000-00027 |
20108443 | [Expression of DC-SIGNR in the primary trophoblast cells and its significance]. | To study the expression of DC-SIGNR in human placenta and trophoblast cells cultured in vitro, and provided a basis for experiment in vitro aiming to investigate the mechanism of receptor-mediated intrauterine transmission. Primary culture system of human chorionic trophoblast cells were established. The expression of ... | |
408220 | Hepatic infarction and diabetic ketoacidosis. | A 36-year-old man with brittle diabetes mellitus developed hepatic infarction immediately after an episode of ketoacidosis. The infarction was documented by angiogram 99mTc sulfur colloid scan, and biopsy. Except for the association with ketoacidosis, no other possible cause of hepatic infarction was found. | |
27288074 | Impulsivity, Stimulant Abuse, and Dopamine Receptor Signaling. | The nonmedical use of amphetamine-type stimulants is a worldwide problem, with substantial medical and social consequences. Nonetheless, the identification of a pharmacological treatment for amphetamine use disorder remains elusive. Stimulant users exhibit neurochemical evidence of dopamine-system dysfunction as well a... | 10.1016/bs.apha.2016.01.002 |
9130747 | Evaluation of intrauterine abnormalities in infertile patients by sonohysterography. | The purpose of this study was to assess the usefulness of sonohysterography in the detection of abnormalities of the uterine cavity in infertile patients, compared with other diagnostic methods. Transvaginal ultrasonography, sonohysterography, hysterosalpingography and finally hysteroscopy were performed in 37 patients... | 10.1093/humrep/12.3.487 |
12112285 | Effects of Melilotus officinalis on acute inflammation. | Our study investigated the effects of Melilotus officinalis L. extract, containing 0.25% coumarin, on acute inflammation induced with oil of turpentine in male rabbits. The results were compared with those from a group treated with hydrocortisone sodium hemisuccinate and one injected with coumarin before inflammation w... | 10.1002/ptr.875 |
37394075 | Comparative study of the toxicity mechanisms of quinolone antibiotics on soybean seedlings: Insights from molecular docking and transcriptomic analysis. | The ecological effects of quinolone antibiotics (QNs) on non-target organisms have received widespread attention. The toxicological mechanisms of three common QNs, that is, enrofloxacin, levofloxacin, and ciprofloxacin, on soybean seedlings were investigated in this study. Enrofloxacin and levofloxacin caused significa... | 10.1016/j.scitotenv.2023.165254 |
38227697 | Coronary Sinus Narrowing Improves Coronary Microcirculation Function in Patients With Refractory Angina: A Multicenter Prospective INROAD Study. | The underlying mechanisms responsible for the clinical benefits following coronary sinus narrowing and pressure elevation remain unclear. The present study aims to investigate whether coronary sinus narrowing improves the indexes of coronary microcirculatory function. Patients with refractory angina who had a clinical ... | 10.1161/CIRCINTERVENTIONS.123.013481 |
15470229 | The structure of cell wall alpha-glucan from fission yeast. | Morphology and structural integrity of fungal cells depend on cell wall polysaccharides. The chemical structure and biosynthesis of two types of these polysaccharides, chitin and (1-->3)-beta-glucan, have been studied extensively, whereas little is known about alpha-glucan. Here we describe the chemical structure of al... | 10.1093/glycob/cwi002 |
29695107 | Microstructure and Deformation Response of TRIP-Steel Syntactic Foams to Quasi-Static and Dynamic Compressive Loads. | The implementation of hollow S60HS glass microspheres and Fillite 106 cenospheres in a martensitically transformable AISI 304L stainless steel matrix was realized by means of metal injection molding of feedstock with varying fractions of the filler material. The so-called TRIP-steel syntactic foams were studied with re... | 10.3390/ma11050656 |
32318693 | Factor, Concurrent and Predictive Validity of the Readiness to Change Questionnaire [Treatment Version] Among Non-Treatment-Seeking Individuals. | This study assessed the factor, concurrent and predictive validity of the revised Readiness to Change Questionnaire [Treatment Version] (RCQ[TV]) among non-treatment-seeking individuals. Non-treatment-seeking patients (Mage = 34.8, SD = 12.4) who screened positive for alcohol misuse were recruited from three urban Leve... | 10.1093/alcalc/agaa021 |
22045518 | Hypovitaminosis D and response to cholecalciferol supplementation in patients with autoimmune and non-autoimmune rheumatic diseases. | Recent reports suggest a role of hypovitaminosis D in the pathogenesis of inflammatory autoimmune diseases (ARD); we investigated 25(OH)vitamin D plasma level before and after supplementation in ARD and NARD (non-ARD: osteoporosis and/or OA) patients. We retrospectively evaluated 572 consecutive clinical records of adu... | 10.1007/s00296-011-2170-x |
33618124 | Low working memory load facilitates attention bias modification training. | Implementations of attention bias modification training (ABMT) attempt to retrain attention away from rather than towards threat, thereby disrupting the anxiety-related attentional bias (AB). Yet, results of ABMT studies have been mixed due to limitations in knowledge of mechanisms underlying ABMT efficacy. Dual-proces... | 10.1016/j.brat.2021.103828 |
9869998 | Inferior vena cava-tricuspid annulus isthmus is a critical site of unidirectional block during the induction of common atrial flutter. | Until recently no clinical studies had reported precise right atrium (RA) mapping when performing induction of atrial flutter (AFl). We studied the mode of tachycardia initiation in 16 patients (pts) referred for radiofrequency (RF) AFl ablation. AFl induction was performed at the beginning of the procedure (n = 10), o... | 10.1023/a:1009768924691 |
18643778 | Mutations linked to interstitial lung disease can abrogate anti-amyloid function of prosurfactant protein C. | The newly synthesized proSP-C (surfactant protein C precursor) is an integral ER (endoplasmic reticulum) membrane protein with a single metastable polyvaline alpha-helical transmembrane domain that comprises two-thirds of the mature peptide. More than 20 mutations in the ER-lumenal CTC (C-terminal domain of proSP-C), a... | 10.1042/BJ20080981 |
32399066 | Wild Leporinus friderici induced spawning with different dose of mGnRHa and metoclopramide or carp pituitary extract. | Breeding technology is of utmost importance for reproduction of wild fish in captivity for the reintroduction and selective breeding programs purposes. The main challenge is that when applied to wild undomesticated specimens, conventional protocols often cause breeders and/or embryo mortality and spawning failure. In t... | 10.21451/1984-3143-AR2019-0078 |
26990689 | Estrogen and ERα enhanced β-catenin degradation and suppressed its downstream target genes to block the metastatic function of HA22T hepatocellular carcinoma cells via modulating GSK-3β and β-TrCP expression. | In our previous experiments, we found β-catenin was highly expressed in the tumor area with high invasive ability and poor prognosis. In this study, we have examined the mechanism by which ERα regulates β-catenin expression as well as the metastasis ability of hepatocellular cancer HA22T cells. To identify whether the ... | 10.1002/tox.22256 |
39409213 | Impedance Spectroscopy Study of Charge Transfer in the Bulk and Across the Interface in Networked SnO 2 /Ga 2 O 3 Core-Shell Nanobelts in Ambient Air. | Metal oxide core-shell fibrous nanostructures are promising gas-sensitive materials for the detection of a wide variety of both reducing and oxidizing gases. In these structures, two dissimilar materials with different work functions are brought into contact to form a coaxial heterojunction. The influence of the shell ... | 10.3390/s24196173 |
1823040 | Superficial bladder cancer: survival and prognostic factors. | Two hundred and seventeen consecutive patients with superficial bladder cancer stages Ta-T1 were analyzed for survival and prognostic factors. The overall 5-year survival was 88 +/- 5.3%. Factors that impacted significantly on survival were: grade of anaplasia (GI 92 +/- 5.9% vs. GII 87 +/- 7.5% vs. GIII 68 +/- 20.7%; ... | 10.1159/000471697 |
23642244 | Functional attachment of soft tissues to bone: development, healing, and tissue engineering. | Connective tissues such as tendons or ligaments attach to bone across a multitissue interface with spatial gradients in composition, structure, and mechanical properties. These gradients minimize stress concentrations and mediate load transfer between the soft and hard tissues. Given the high incidence of tendon and li... | 10.1146/annurev-bioeng-071910-124656 |
30915094 | Induced Systemic Resistance (ISR) and Fe Deficiency Responses in Dicot Plants. | Plants develop responses to abiotic stresses, like Fe deficiency. Similarly, plants also develop responses to cope with biotic stresses provoked by biological agents, like pathogens and insects. Some of these responses are limited to the infested damaged organ, but other responses systemically spread far from the infes... | 10.3389/fpls.2019.00287 |
16334703 | Off-axis effects on the multipulse structure of sperm whale usual clicks with implications for sound production. | Sperm whales (Physeter macrocephalus) produce multipulsed clicks with their hypertrophied nasal complex. The currently accepted view of the sound generation process is based on the click structure measured directly in front of, or behind, the whale where regular interpulse intervals (IPIs) are found between successive ... | 10.1121/1.2082707 |
38899488 | Bioluminescent aptamer-based microassay for detection of melanoma inhibitory activity protein (MIA). | Melanoma inhibitory activity protein (MIA) does obviously offer the potential to reveal clinical manifestations of melanoma. Despite a pressing need for effective diagnosis of this highly fatal disease, there are no clinically approved MIA detection ELISA kits available. A recommended MIA threshold has not yet been def... | 10.1039/d4ay00706a |
1379093 | Effects of chronic amitriptyline administration on saliva from the parotid and submandibular glands of the rat. | The effect of prolonged treatment with amitriptyline on the secretory activity of rat salivary glands evoked by parasympathetic nerve stimulation and isoprenaline administration has been studied. Low doses of amitriptyline (10 mg/kg per day for 2 or 4 weeks), did not significantly affect salivary flow evoked by either ... | 10.1007/BF01824205 |
1523400 | The impact of the banning of tributyltin-based antifouling paints on the Sydney rock oyster, Saccostrea commercialis. | Two years after the banning in New South Wales (Australia) of tributyltin (TBT)-based antifouling paints for vessels under 25 metres in length, the impact on the Sydney rock oyster, Saccostrea commercialis, has been assessed. Reduced growth and shell deformities present before banning were found to be absent and health... | 10.1016/0048-9697(92)90048-w |
10221285 | Treatment of restless legs syndrome with tramadol: an open study. | Tramadol is a central analgesic that seems to have fewer side effects and a lower abuse potential than classical opioids. Since the treatment of restless legs syndrome (RLS) with levodopa or classical opioids is problematic, new treatment possibilities would be valuable. We treated 12 patients who fulfilled at least th... | 10.4088/jcp.v60n0407 |
15503711 | Overview of adult outcomes in pediatric-onset spinal cord injuries: implications for transition to adulthood. | To provide an overview of the adult outcomes of individuals with pediatric-onset spinal cord injuries (SCIs) and the implications of those findings for transition to adulthood. Structured interview including standardized measures. Individuals who sustained SCI at or = 24 years of age at interview; matched community c... | 10.1080/10790268.2004.11753545 |
31220173 | Vital signs and impaired cognition in older emergency department patients: The APOP study. | Cognitive impairment is a frequent problem among older patients attending the Emergency Department (ED) and can be the result of pre-existing cognitive impairment, delirium, or neurologic disorders. Another cause can also be acute disturbance of brain perfusion and oxygenation, which may be reversed by optimal resuscit... | 10.1371/journal.pone.0218596 |
10391948 | A cytoskeletal localizing domain in the cyclase-associated protein, CAP/Srv2p, regulates access to a distant SH3-binding site. | In the yeast, Saccharomyces cerevisiae, adenylyl cyclase consists of a 200-kDa catalytic subunit (CYR1) and a 70-kDa subunit (CAP/SRV2). CAP/Srv2p assists the small G protein Ras to activate adenylyl cyclase. CAP also regulates the cytoskeleton through an actin sequestering activity and is directed to cortical actin pa... | 10.1074/jbc.274.28.19985 |
18756747 | [The risk factors and clinical forms of diabetic foot infections in dependence on the type of diabetes mellitus]. | The aim of the work--the study of risk factors and detection of prevailing clinical form of diabetic foot infections (DFI) in dependence on type diabetes mellitus (DM). 157 patients with DM and DFI (25 type 1 DM cases and 132 type 2 DM cases) and 689 DM patients without DFI (282 type 1 DM cases and 407 type 2 DM cases)... | |
6952287 | Reye's syndrome and aspirin use: a possible immunological relationship. | Reye's syndrome is a serious childhood disease usually associated with an antecedent viral illness such as influenza or chicken pox. Recent reports indicate a relationship between moderate aspirin use during the viral infection and the development of Reye's disease. The blastogenic response of cultured lymphocytes to l... | 10.1016/0262-1746(82)90044-0 |
31430248 | Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2017-2018. | We characterized exposures and demographics of Middle East respiratory syndrome coronavirus cases reported to the Saudi Arabia Ministry of Health during July 1-October 31, 2017, and June 1-September 16, 2018. Molecular characterization of available specimens showed that circulating viruses during these periods continue... | 10.3201/eid2511.190726 |
23499537 | Spatial distribution and historical input of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in sediments from a subtropical estuary (Guaratuba Bay, SW Atlantic). | This study evaluated the occurrence and distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in 22 surface sediment samples and one core collected in Guaratuba Bay, a large and well-preserved estuary in Southern Atlantic, Brazil. The concentration of PCBs in the superficial sediment sam... | 10.1016/j.marpolbul.2013.02.022 |
1325724 | Field trials of an inactivated virus vaccine against porcine parvovirus. | Serological response and reproductive performance were estimated in field trials of an inactivated virus vaccine against porcine parvovirus. Experiments were carried out in 10 selected pig breeding herds. A total of 277 seronegative gilts were used. Two hundred and twenty animals were vaccinated twice before mating, fo... | 10.1111/j.1439-0450.1992.tb01178.x |
19411558 | Dose-response models: how might we think about linearity and nonlinearity? | We add to the issues raised by Dr David Ropeik's article Risk Communication and Non-Linearity (forthcoming, BELLE Newsletter, 2008) regarding the thinking about the acceptance of linear and nonlinear (hormetic) dose-response models. We summarize some of the perceptual aspects discussed by Ropeik (2008) and comment on d... | 10.1177/0960327109103524 |
27836886 | Dietary acrylamide and the risk of pancreatic cancer in the International Pancreatic Cancer Case-Control Consortium (PanC4). | Occupational exposure to acrylamide was associated with excess mortality from pancreatic cancer, though in the absence of dose-risk relationship. Few epidemiological studies have examined the association between acrylamide from diet and pancreatic cancer risk. We considered this issue in a combined set of 1975 cases of... | 10.1093/annonc/mdw618 |
15131475 | Interferon-alpha and lamivudine combination therapy of children with chronic hepatitis b infection who were interferon-alpha nonresponders. | Greater than one-half of children with chronic hepatitis B infection are nonresponders to interferon-alpha (IFN-alpha). The aim of this study was to investigate the efficacy of lamivudine (LMV) and IFN-alpha combination therapy in these children. Nineteen children were given LMV alone for 3 months; then IFN-alpha was a... | 10.1097/01.inf.0000122611.11236.42 |
2900130 | Effects of alpha-adrenoceptor blockers on renal function and blood pressure adjustment in human hypertension. | In this paper the different aspects of the role played by alpha-adrenoceptors in the control of renin secretion from the juxtaglomerular apparatus and renal sodium and water reabsorption, and the effects of alpha-adrenoceptor antagonists on systemic haemodynamics, will be investigated. Animal experiments suggest that t... | 10.2165/00003495-198800356-00007 |
8531026 | Central venous catheter infection with Rhodotorula minuta in a patient with AIDS taking suppressive doses of fluconazole. | A case of Rhodotorula minuta central venous catheter infection with fungaemia is described in a patient with advanced acquired immunodeficiency syndrome (AIDS), HIV nephropathy, end-stage renal disease requiring haemodialysis, and a permanent Quinton catheter in place for 6 months. At the time of fungaemia, the patient... | 10.1080/02681219580000531 |
38675550 | Investigating the Catalytic Influence of Boron on Ni-Co/Ca Catalysts for Improved Syngas Generation from Rice Straw Pyrolysis. | A series of boron-promoted Ni-Co/Ca catalysts were synthesized by the sol-gel method to enhance syngas generation from biomass pyrolysis. The efficiency of these catalysts was evaluated during the pyrolysis of rice straw in a fixed-bed reactor, varying the Ni/Co ratio, boron addition, calcination temperature, and resid... | 10.3390/molecules29081730 |
33610121 | Two transcription factors PU.1a and PU.1b have different functions in the immune system of teleost ayu. | Transcription factor PU.1 is a regulator of macrophage function, however, the specific function of PU.1 in teleost monocytes/macrophages (MO/MФ) remains unknown. We determined the cDNA sequence of two PU.1 genes from ayu (Plecoglossus altivelis; PaPU.1a and PaPU.1b). Sequence comparisons showed that PaPU.1 were most cl... | 10.1016/j.molimm.2021.02.004 |
9340027 | [The significance of endothelin for physiologic and pathophysiologic processes of the lung]. | The endothelins (ETs) are a family of three vasoactive peptides (ET-1, ET-2, ET-3) that were first described in 1988. ETs have a wide range of action including vasoconstriction, vasodilatation, bronchoconstriction, and mitogenesis. Two types of ET receptors, classified as ETA and ETB receptors, have been identified in ... | 10.1055/s-2007-995080 |
22345578 | TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors. | We addressed the hypothesis that allergic inflammation in guinea pig airways leads to a phenotypic switch in vagal tracheal cough-causing, low-threshold mechanosensitive Aδ neurons, such that they begin expressing functional transient receptor potential vanilloid (TRPV1) channels. Guinea pigs were actively sensitized t... | 10.1152/ajplung.00366.2011 |
31887304 | Take a deep breath and wake up: The protean role of serotonin preventing sudden death in infancy. | Recordings from infants who died suddenly and unexpectedly demonstrate the occurrence of recurring apneas, ineffective gasping, and finally, failure to restore eupnea and arouse prior to death. Immunohistochemical and autoradiographic data demonstrate a constellation of serotonergic defects in the caudal raphe nuclei i... | 10.1016/j.expneurol.2019.113165 |
33617250 | Diagnosing the SEI Layer in a Potassium Ion Battery Using Distribution of Relaxation Time. | Understanding the solid electrolyte interphase (SEI) formation process in novel battery systems is of primary importance. Alongside increasingly powerful in situ techniques, searching for readily accessible, noninvasive, and low-cost tools to probe battery chemistry is highly demanded. Here, we applied distribution of ... | 10.1021/acs.jpclett.1c00118 |
34623379 | Thermodynamic and structural basis of temperature-dependent gating in TRP channels. | Living organisms require detecting the environmental thermal clues for survival, allowing them to avoid noxious stimuli or find prey moving in the dark. In mammals, the Transient Receptor Potential ion channels superfamily is constituted by 27 polymodal receptors whose activity is controlled by small ligands, peptide t... | 10.1042/BST20210301 |
23314461 | AEGD programs: why now, why more? | With an increased number of dental schools graduating more dentists, along with the opening of new dental schools throughout the United States, more graduating dental students are considering utilizing Advanced Education in General Dentistry (AEGD) programs as a means to increase their understanding of the complexity o... | |
31334580 | MicroRNA-191 promotes hepatocellular carcinoma cell proliferation by has_circ_0000204/miR-191/KLF6 axis. | MicroRNAs are powerful regulators in hepatocellular carcinoma (HCC) tumorigenesis. MicoRNA-191 (miR-191) has been reported to play an important role in HCC, However, the regulatory mechanism is still unclear. In this study, we investigated the role of miR-191 in HCC and studied its underlying mechanisms of action. The ... | 10.1111/cpr.12635 |
1975690 | Site- and stereospecific ocular drug delivery by sequential enzymatic bioactivation. | Intraocular enzymes convert the ketoxime analogues of some beta-adrenergic blockers via a sequential bioactivation process involving hydrolysis to the corresponding ketones followed by reduction to the aryloxyaminoalcohols, which then exert known and predictable physiological and pharmacological effects only at the sit... | 10.1023/a:1015863521513 |
37434456 | Peroxiredoxin 3 Inhibits Cardiac Fibrosis in Mice via NOX4-P38 Signalling. | Peroxiredoxin-3 (Prx-3) is widely acknowledged as an antioxidant that protects against mitochondrial reactive oxygen species. Nonetheless, its role in cardiac fibrosis has not been elucidated. We aim to explore the role and mechanism of Prx-3 in cardiac fibrosis. In this experimental study, mice received subcutaneous i... | 10.22074/cellj.2023.557603.1082 |
25760790 | A service dog in group. | Service dogs are sanctioned by the Americans with Disabilities Act as having protected rights allowing them to assist owners with disabilities. These dogs are appearing with increasing frequency in healthcare settings, and it is important for healthcare providers to understand the rules and regulations given to service... | 10.1521/ijgp.2015.65.2.307 |
3306498 | Fetal biophysical profile and perinatal death. | Antepartum assessment of 5034 high-risk pregnancies to predict perinatal death included five biophysical variables (nonstress test, fetal breathing movements, fetal movements, fetal tone, and amniotic fluid volume) which combined to form a biophysical profile score. We assessed 4148 fetuses within seven days of deliver... | |
24499505 | Polycyclic Aromatic Hydrocarbons in drinking water of Tehran, Iran. | Distribution and seasonal variation of sixteen priority polycyclic aromatic hydrocarbons (PAHs) were investigated in the drinking water of Tehran, the capital of Iran. Detected single and total PAHs concentrations were in the range of 2.01-38.96 and 32.45-733.10 ng/L, respectively, which were quite high compared to the... | 10.1186/2052-336X-11-25 |
31758690 | In vitro antifungal activity of luliconazole against nondermatophytic moulds. | In vitro antifungal activity of luliconazole against nondermatophytic moulds causing superficial infections was compared with that of five classes of 12 topical and systemic drugs. The minimum inhibitory concentration (MIC) of the drugs against the genera of Neoscytalidium, Fusarium, Aspergillus, Scedosporium, and Alte... | 10.1093/mmy/myz117 |
15269390 | Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice. | In vitro inhibitors of the accumulation of abnormal (protease-resistant) prion protein (PrP-res) can sometimes prolong the lives of scrapie-infected rodents. Here, transgenic mice were used to test the in vivo anti-scrapie activities of new PrP-res inhibitors, which, because they are approved drugs or edible natural pr... | 10.1099/vir.0.80082-0 |
33691411 | An Immunochemical Approach to Quantify and Assess the Potential Value of the Pseudomonas Quinolone Signal as a Biomarker of Infection. | Quorum sensing (QS) is a bacterial cell density-based communication system using low molecular weight signals called autoinducers (AIs). Identification and quantification of these molecules could provide valuable information related to the stage of colonization or infection as well as the stage of the disease. With thi... | 10.1021/acs.analchem.0c04731 |
37455270 | Quail Rearing Practices and Potential for Avian Influenza Virus Transmission, Bangladesh. | In 2015, human influenza surveillance identified a human infection with A/H9N2 in Dhaka, Bangladesh with evidence of exposure to a sick quail. We conducted in-depth interviews with household quail caregivers, pet bird retail shop owners, and mobile vendors, key informant interviews with pet bird wholesale shop owners, ... | 10.1007/s10393-023-01643-w |
19279289 | Disengaging insulin from corticosterone: roles of each on energy intake and disposition. | Corticosterone and insulin play complex roles in the amount and composition of calories ingested, and the utilization and deposition of this energy. Understanding the interplay of these two hormones is complicated because increasing concentrations of corticosterone dose-dependently increase circulating insulin levels. ... | 10.1152/ajpregu.91016.2008 |
22028735 | Suicidal behavior in the older patient with schizophrenia. | Little is known about treating elderly suicidal patients with schizophrenia. The purpose of this article is to review the literature dealing with this population and to discuss what is required to advance this field. Most available studies from middle-aged and older individuals suggest that risk factors include hopeles... | 10.2217/ahe.11.23 |
33351111 | The evolution of factor XI and the kallikrein-kinin system. | Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted to FXIa by factor XIIa (FXIIa), a component, along with prekallikrein and high-molecular-weight kininogen (HK), of the plasma kallikrein... | 10.1182/bloodadvances.2020002456 |
30151321 | Qip gene in Fusarium oxysporum is required for normal hyphae morphology and virulence. | Ribonucleic acid (RNA)-silencing mechanisms exist in many eukaryotes to regulate a variety of biological processes. The known molecular components are related to Dicers, Argonautes and RNA-dependent RNA polymerases. Previous biochemical studies have also suggested that Qip, with an exonuclease domain, facilitates the c... | 10.1080/21501203.2015.1027313 |
2617992 | [The role of immunogenetic research in studying hypertension]. | The distribution of antigens of the main complex of histocompatibility was studied in 50 patients suffering of hypertensive disease complicated by cerebrovascular disfunction of the brain. A correlation was found between the development of hypertensive disease and several antigens. Results of the study confirm the role... | |
30526176 | Protective mechanism of Wnt4 gene on Parkinson's disease (PD) transgenic Drosophila. | The main pathological change of Parkinson's disease (PD) is progressive degeneration and necrosis of dopaminergic neurons in the midbrain, forming a Lewy body in many of the remaining neurons. Studies have found that in transgenic Drosophila, mutations in the PTEN-inducible kinase 1 (PINK1) gene may cause indirect flig... | 10.1080/00207454.2018.1557168 |
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