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id stringlengths 40 40	title stringlengths 15 120	text stringlengths 41 3.14k	source stringclasses 2 values
83f819664db6848379f368360472d38423860bd4	enzyme substitution therapy using pal to treat phenylketonuria	enzyme substitution therapy using pal to treat phenylketonuria (pku), an autosomal recessive genetic disorder in humans in which mutations in the phenylalanine hydroxylase (pah, ec 1.14.16.1) gene inactivate the enzyme is being explored. this leads to an inability of the patient to metabolize phenylalanine, causing ele...	wikipedia
80202695c408bb430c9dabf1274634c47df80d75	phenylalanine ammonia lyase can perform different functions in	phenylalanine ammonia lyase can perform different functions in different species. it is found mainly in some plants and fungi (i.e. yeast). in fungal and yeast cells, pal plays an important catabolic role, generating carbon and nitrogen. in plants it is a key biosynthetic enzyme that catalyzes the first step in the syn...	wikipedia
871d43eab7b1b2b86f1db3fec7ac1fe67e02fd9a	phenylalanine ammonia lyase is composed of four identical	phenylalanine ammonia lyase is composed of four identical subunits composed mainly of alpha-helices, with pairs of monomers forming a single active site. catalysis in pal may be governed by the dipole moments of seven different alpha helices associated with the active site. the active site contains the electrophilic gr...	wikipedia
a5cc8e30bb6f26e1b1821d0a550903421c654403	pal is inhibited by trans-cinnamic acid, and, in	pal is inhibited by trans-cinnamic acid, and, in some species, may be inhibited by trans- cinnamic acid derivatives. the unnatural amino acids d -phe and d -tyr, the enantiomeric forms of the normal substrate, are competitive inhibitors.	wikipedia
276c4f0087255ca878c927afaf674bd7bfbc2ba0	a dehydroalanine residue was long thought to be	a dehydroalanine residue was long thought to be the key electrophilic catalytic residue in pal and hal, but the active residue was later found instead to be mio, which is even more electrophilic. it is formed by cyclization and dehydration of conserved ala-ser-gly tripeptide segment. the first step of mio formation is ...	wikipedia
89b7d1713c2fcbed4c0994caf62357ce416e9e2e	the cofactor 3,5-dihydro-5-methyldiene-4 h -imidazol-4-one (mio) is involved	the cofactor 3,5-dihydro-5-methyldiene-4 h -imidazol-4-one (mio) is involved in the reaction and sits atop the positive pole of three polar helices in the active site, which helps to increase its electrophilicity. mio is attacked by the aromatic ring of l -phe, which activates the c-h bond on the β carbon for deprotona...	wikipedia
f52cb4cee8a4cd4354366a168fc2e533606d8781	the enzyme is a member of the ammonia	the enzyme is a member of the ammonia lyase family, which cleaves carbon–nitrogen bonds. like other lyases, pal requires only one substrate for the forward reaction, but two for the reverse. it is thought to be mechanistically similar to the related enzyme histidine ammonia-lyase (ec:4.3.1.3, hal). the systematic name ...	wikipedia
7eac596dc25b0723d87640e691f2bab64d75ebfe	phenylalanine ammonia lyase (pal) is the first and	phenylalanine ammonia lyase (pal) is the first and committed step in the phenyl propanoid pathway and is therefore involved in the biosynthesis of the polyphenol compounds such as flavonoids, phenylpropanoids, and lignin in plants. phenylalanine ammonia lyase is found widely in plants, as well as some bacteria, yeast, ...	wikipedia
b6b57026c616e1815b08b967ceaf8f2dc6a2065e	huang joined the faculty at purdue university. in	huang joined the faculty at purdue university. in 2011, she was a kavli foundation fellow. her research considers the development of ultrafast, spatially resolved spectroscopies to understand charge transport in the active layers of solar cells. she has developed ultrafast spectroscopic probes that can be combined with...	wikipedia
e40eae90a32a5502e6ea01645b03778f892afd09	huang earned a doctorate bs from peking university	huang earned a doctorate bs from peking university in 2001 and a phd from university of rochester in 2006. her doctorate developed ultrafast nonlinear optical spectroscopy of single-wall carbon nanotubes. huang then joined argonne national laboratory as a postdoctoral fellow.	wikipedia
17afc92ff09cbab26b245887bbce88bfb2298bb3	david broll is a retired canadian professional ice	david broll is a retired canadian professional ice hockey player. he last played with the coventry blaze in the eihl. broll was selected by the toronto maple leafs in the sixth round of the 2011 nhl entry draft.	wikipedia
d2f1431b1a50d2e27f12f617b7e05a3425487ecd	on june 18, 2019, broll opted to sign	on june 18, 2019, broll opted to sign his first contract abroad, agreeing to a one-year contract with english club, coventry blaze of the elite ice hockey league. he collected 18 points in 35 regular season games with the blaze and served as an alternate captain. having returned to north america during the covid-19 pan...	wikipedia
79a81891a9febd3b1f47b2f86334591414dcd6d5	as a free agent from the lightning following	as a free agent from the lightning following the conclusion of his entry-level deal, broll was unable to attain another nhl deal. on september 21, 2016, he signed a professional try-out contract to attend the montreal canadiens training camp. he was later signed to a one-year contract with echl affiliate, the brampton ...	wikipedia
df2ae1e0bab3d2e0e2c39ae185c1a6298bb0eaef	the maple leafs signed broll to an entry-level	the maple leafs signed broll to an entry-level contract on july 31, 2011. he was assigned to the maple leafs's american hockey league (ahl) affiliate, the toronto marlies. broll was recalled by the maple leafs at the beginning of the 2013–14 season after an injury to joffrey lupul forced them to make line changes and o...	wikipedia
3873c304e0cd3c8755e95e4c4bbc68524bc5a54b	broll played four seasons (2009 – 2013) of	broll played four seasons (2009 – 2013) of major junior hockey in the ontario hockey league (ohl), scoring 47 goals and 92 assists for 139 points, while earning 285 penalty minutes, in 255 games played with the erie otters and sault ste. marie greyhounds. he was selected by the toronto maple leafs 152nd overall in the ...	wikipedia
e26a2760b4d53e8c0d400dfaa487c6317b87f522	david broll (born january 4, 1993) is a	david broll (born january 4, 1993) is a retired canadian professional ice hockey player. he last played with the coventry blaze in the eihl. broll was selected by the toronto maple leafs in the sixth round (152nd overall) of the 2011 nhl entry draft.	wikipedia
68e442804faa1cfe3a4df88679a8fd7ae4bd8fbd	howard janotta was an american professional basketball player.	howard janotta was an american professional basketball player. after a collegiate career at long island university and then seton hall university, janotta played for the baltimore bullets in 9 games during the 1949–50 nba season. born in hackensack, new jersey, janotta grew up in nearby little ferry and attended lodi h...	wikipedia
12435a345648541d70352df00ff1c85bb55c9f84	howard janotta (october 19, 1924 – november 22,	howard janotta (october 19, 1924 – november 22, 2010) was an american professional basketball player. after a collegiate career at long island university and then seton hall university, janotta played for the baltimore bullets in 9 games during the 1949–50 nba season.	wikipedia
e6a26870a7148c8ad6fd8a5c56859b79f19ff9a1	jeffrey joaquin cariaso is a filipino-american professional basketball	jeffrey joaquin cariaso is a filipino-american professional basketball coach and former player. he is the head coach of the blackwater bossing of the philippine basketball association (pba). he also played for various pba teams, mostly with alaska, for 15 seasons. he is known as "the jet". he is also the basketball ope...	wikipedia
bcaefeeae724826979047e33e160c8f379a77fd0	cariaso is engaged to sports news reporter erika	cariaso is engaged to sports news reporter erika padilla, who was two months pregnant with her first child when he proposed. he was previously married to michelle, with whom he shares 4 children. jeffrey is a graduate of mission high school in san francisco, ca.	wikipedia
9b29ade26b1176fb51e8b39814718748af66742b	on april 29, 2014, cariaso was named as	on april 29, 2014, cariaso was named as the new head coach of barangay ginebra, replacing ato agustin. prior to this, he has no high-level head coaching experience. in fact, he has little coaching experience apart from san mig coffee, joining the team in 2011, one year after retiring as a player, to assist his former c...	wikipedia
bf13df54ffc2381849313fabd63f459fd7adb647	in the semifinals of the 2010 pba fiesta	in the semifinals of the 2010 pba fiesta conference, he announced his retirement after playing 15 seasons in the league. his number 22 was also retired by the alaska aces and the coca-cola tigers.	wikipedia
541bfaa3501ec657a6706b0c7c884c77c1b8bc9a	after tanduay folded in 2001, he was then	after tanduay folded in 2001, he was then picked by the coca-cola tigers where he got reunited with johnny abarrientos. they won a couple of championships which include the 2002 all-filipino cup against his former team alaska and the 2003 reinforced conference against san miguel. he last tasted a championship with talk...	wikipedia
4dc70a262493b78cacb607e3b0310e4bd2db557d	before the start of the 1997 pba season,	before the start of the 1997 pba season, cariaso was traded to the mobiline phone pals (now known as the tnt tropang texters) where he was a primary offensive threat for the team. they won the special 1998 centennial cup.	wikipedia
fd9a3380a26fc1ed5498fc94270eef432e07ecbd	he was first drafted by the alaska aces	he was first drafted by the alaska aces (then known as the alaska milkmen) during the 1995 pba draft as the sixth overall. during his rookie year, he won the rookie of the year award. and in only his second year in the league, he achieved a rare grand slam with the aces where he was instrumental in that majestic champi...	wikipedia
f0fb391b1ccb04faea7dea919271d3f75c5c7ffd	jeffrey joaquin cariaso is a filipino-american professional basketball	jeffrey joaquin cariaso is a filipino-american professional basketball coach and former player. he is the head coach of the blackwater bossing of the philippine basketball association (pba). he also played for various pba teams, mostly with alaska, for 15 seasons. he is known as " the jet ". he is also the basketball o...	wikipedia
02b751a19cda063c7d0a63d14b95c4402b5fd52f	the 2011–12 season was stevenage f.c.'s second season	the 2011–12 season was stevenage f.c.'s second season in the football league, where the club competed in league one. this article shows statistics of the club's players in the season, and also lists all matches that the club played during the season. their sixth-place finish and subsequent successful play-off campaign ...	wikipedia
f8b242464966b71b3d8999f1cd0d218db17fc36c	the 2011–12 season was stevenage f.c.'s second season	guy madjo, who joined on a free transfer from albanian superliga side ks bylis ballsh. former stevenage goalkeeper alan julian re-joined the club following his release by gillingham, while phil edwards rejected a contract extension at accrington stanley in order to join the hertfordshire club on a free transfer. midfi...	wikipedia
2d71c04244a5bfb771c7c86dc8a95df4a2be40f3	the 2011–12 season was stevenage f.c.'s second season	in february 2012, securing a 1–0 victory. sitting in the play-off places with a number of games in hand, stevenage went on to win just one league game out of the following thirteen, although nine of which were draws. the poor run of form left stevenage in ninth position, and six points behind the play-off places with ...	wikipedia
96573bf481c8a87584eba9084b155c3a07e9d9cc	the 2011–12 season was stevenage f.c.'s second season	venage's top goalscorer for the season with ten goals in all competitions. captain mark roberts played every single minute of stevenage's 56 matches during the season. roberts ended up winning the player of the year award for the season, with michael bostwick winning players' player of the year.	wikipedia
6f87e273868a27f1f67b8ac1492359fe5061ccfe	stevenage were awarded a bye to the second	stevenage were awarded a bye to the second round of the football league trophy. this is because the competition is split into northern and southern sections, with eight clubs in each section bypassing the first round draw. the draw was made on 3 september 2011, with stevenage being dealt an away tie against afc wimbled...	wikipedia
901663d1301746f3b7655dddf591618942f3a39f	the draw for the fifth round was made	the draw for the fifth round was made on 29 january, with stevenage being dealt a home tie against premier league side tottenham hotspur. the game was played on 19 february, and was also televised on itv, ending in a 0–0 draw. tottenham had the ball in the net early in the second-half, but louis saha 's shot hit scott ...	wikipedia
34df86a95380f2c42c32c04d74f5777c29bf39b6	the third round draw was made a day	the third round draw was made a day after the stourbridge victory, on 4 december, with the club being dealt an away tie against championship club reading. the two sides had met the year before, with reading knocking stevenage out of the fa cup during the 2010–11 campaign, beating stevenage 2–1 at broadhall way in the f...	wikipedia
960881119a68bc204cb8095b16e7407b3fbba540	the club entered the 2011–12 fa cup at	the club entered the 2011–12 fa cup at the first round stage — only the second time the club had entered the competition at this stage since 1997. the first round draw was made on 29 october, with stevenage facing an away trip to league one side hartlepool united. the game was played on 12 november, with stevenage secu...	wikipedia
3494c28e89530386fa36d11b5b594ed0d87c6260	first round fixtures for the competition were released	first round fixtures for the competition were released on 16 june 2011, with stevenage being drawn against championship opposition in the form of peterborough united at broadhall way. the match ended 4–3 to peterborough, with the game having gone to extra-time. the visitors took the lead after twenty minutes, david bal...	wikipedia
4e2d8fc53a3497910482bea846fa864650cb6a79	as a result of stevenage finishing sixth in	as a result of stevenage finishing sixth in the league, they faced third placed sheffield united over two legs in the league one play-off semi-finals. due to sheffield united's higher standing in the league table, stevenage had home advantage in the first leg, with the game being played on 11 may 2012, televised live o...	wikipedia
ed6bd6e19303dbabaff5f675ed6816a99e9ff826	similarly to the 2010–11 campaign, stevenage faced bury	similarly to the 2010–11 campaign, stevenage faced bury at home for the final game of the regular season. the team knew that a win against bury would secure a place in the play-offs, irrespective of what both play-off rivals, notts county and carlisle united, did in their respective games. stevenage won the match 3–0, ...	wikipedia
a6ab7049bdc3b8fa35532a931d8f513592555e6a	stevenage's nine game unbeaten run was ended on	stevenage's nine game unbeaten run was ended on 6 april, losing 3–0 away to tranmere rovers courtesy of two early goals from on loan striker jake cassidy, and a second-half strike from lucas akins. three days later, on 9 april, stevenage welcomed preston north end to broadhall way, signalling the return of former manag...	wikipedia
4b98774a4f7d7025b192debe34dd74e2a3bdd378	stevenage's nine game unbeaten run was ended on	long pass, before calmly beating sam walker in the yeovil goal. two goals within the space of three second half minutes put the game beyond doubt, with jon ashton and lascelles scoring headers from set pieces. mark roberts added a fifth goal with ten minutes remaining — prodding in freeman's centre. freeman then score...	wikipedia
dbbb16cbda1cf1aa7dc29b87561f5b924dd8ce6a	stevenage's nine game unbeaten run was ended on	deemed jon ashton to have fouled morrison. brentford's sam saunders stepped up and his powerful penalty rebounded off the post and into the arms of chris day. just three minutes after the second penalty miss, stevenage were one goal to the good. craig reid controlled lawrie wilson's low cross, before hitting a shot on...	wikipedia