IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
P05412 | Q14164 | 0 | phosphorylation | up-regulates activity | 0.316 | Indeed, using an in vitro kinase assay, we demonstrated that both JNK and IKKepsilon phosphorylated c-Jun (XREF_FIG and XREF_SUPPLEMENTARY). | SIGNOR-279621 |
P11309 | P08183 | 1 | dephosphorylation | up-regulates activity | 0.438 | Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function|P-gp is known to be phosphorylated at Ser667, Ser671, and Ser683 by PKA; at Ser661, Ser667, and Ser671 by PKC; and at Ser683 by Pim-1|simultaneous expression of PP5 and PPP2R3C reduced the phosph... | SIGNOR-272511 |
Q15796 | Q9UQM7 | 0 | phosphorylation | down-regulates | 0.549 | Smad2 is a target substrate for cam kinase ii in vitro at serine-110, -240, and -260. furthermore, cam kinase ii blocked nuclear accumulation of a smad2 and induced smad2-smad4 hetero-oligomerization independently of tgfbeta receptor activation, while preventing tgfbeta-dependent smad2-smad3 interactions. | SIGNOR-82970 |
Q13283 | P68400 | 0 | phosphorylation | down-regulates activity | 0.239 | We also show that casein kinase 2 phosphorylates G3BP1 at serine 149 in vitro and in cells. These data support a role for casein kinase 2 in regulation of protein synthesis by downregulating stress granule formation through G3BP1.CK2 regulates SG disassembly during stress recovery.G3BP1 is among the strongest SG nuclea... | SIGNOR-260748 |
Q14493 | Q5QNW6 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265394 |
Q15121 | P31749 | 0 | phosphorylation | up-regulates activity | 0.517 | Protein kinase b/akt binds and phosphorylates ped/pea-15, stabilizing its antiapoptotic action. | SIGNOR-102092 |
P49768 | P45984 | 0 | phosphorylation | up-regulates | 0.376 | This jnk phosphorylation of ps1 at ser(319)thr(320) enhances the stability of the ps1 c-terminal fragment that is necessary for gamma-secretase activity. | SIGNOR-179676 |
P45983 | P40763 | 1 | phosphorylation | up-regulates activity | 0.567 | Transfection of the cells with sirna specific for jnk1 revealed that jnk silencing reduced serine727 phosphorylation of stat3, | SIGNOR-235704 |
Q16659 | O60229 | 1 | phosphorylation | up-regulates activity | 0.406 | The brain-specific nucleotide exchange factor kalirin-7 (Kal7) was identified as an MK5 interaction partner and substrate protein. The MK5 substrate Kal7, a Rho GEF and known activator of Rac GTPases, further contributes to PAK activation and actin filament reorganization. Thus, the coordinated phosphorylation of Borg ... | SIGNOR-263094 |
P07948 | Q14790 | 1 | phosphorylation | down-regulates activity | 0.311 | The non-receptor tyrosine kinase, Lyn, can phosphorylate caspase-8 on Tyr-397 and Tyr-465, rendering it resistant to activational cleavage and inhibiting apoptosis. | SIGNOR-272980 |
Q6NYC1 | Q7L2J0 | 1 | cleavage | down-regulates activity | 0.268 | JMJD6 cleaves MePCE. we propose that JMJD6 is the cognate protease of MePCE and cleaves at the R171 site within MePCE. Experiments using purified JMJD6 showed that it could make a cut in an enzyme called MePCE, which belongs to the group of proteins that hold P-TEFb in its inactive form. The levels of activated Pol II ... | SIGNOR-261037 |
Q14493 | Q6DN03 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265382 |
Q16827 | P12931 | 1 | dephosphorylation | down-regulates activity | 0.422 | SRC activation triggered by loss of PTPRO leads to c-CBL degradation.|These data corroborate that PTPRO directly dephosphorylates SRC at Y416. | SIGNOR-277004 |
P17252 | Q9UKF7 | 1 | phosphorylation | up-regulates activity | 0.319 | Only BIM-I caused a reduction in 14-3-3 binding (Figure 3B), suggesting that PKC could be responsible for one or both of the serine phosphorylations, pSer274 and pSer299. | SIGNOR-273801 |
P68431 | Q9UPS6 | 0 | methylation | down-regulates activity | 0.2 | SETD1B encodes a lysine-specific methyltransferase that assists in transcriptional activation of genes by depositing H3K4 methyl marks. | SIGNOR-265576 |
O14965 | P04637 | 1 | phosphorylation | up-regulates activity | 0.778 | The N-terminus of E2F1 can interact directly with a region towards the C-terminus of p53, resulting in increased nuclear retention of p53 and p53-mediated transcription and apoptosis. This is inhibited by competition between p53 and cyclin A at the binding site within E2F19,10. The interaction between p53 and E2F1 is e... | SIGNOR-120836 |
P25490 | Q13547 | 0 | deacetylation | down-regulates activity | 0.798 | Previous studies have established that YY1 interacts with histone acetyltransferases p300 and CREB-binding protein (CBP) and histone deacetylase 1 (HDAC1), HDAC2, and HDAC3. Here, we present evidence that the activity of YY1 is regulated through acetylation by p300 and PCAF and through deacetylation by HDACs. YY1 was a... | SIGNOR-268835 |
Q9BXS6 | P06493 | 0 | phosphorylation | down-regulates | 0.431 | We report here that cdk1 phosphorylates nusap at threonine 300 and 338 in early mitosis. Phosphorylation of nusap inhibits its microtubule-binding activity in vitro and in vivo. | SIGNOR-177549 |
P50281 | P02679 | 1 | cleavage | down-regulates quantity by destabilization | 0.2 | Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII| We have now investigated the role of collagenase-2 (MMP-8), macrophage elastase (MMP-12), collagenase-3 (MMP-13), and membrane type 1-mat... | SIGNOR-263616 |
Q16539 | O75676 | 1 | phosphorylation | up-regulates | 0.604 | Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were requ... | SIGNOR-77212 |
Q9NXA8 | P07195 | 1 | deacetylation | up-regulates activity | 0.2 | In colorectal cancer, SIRT5 binds to lactate dehydrogenase B (LDHB) to deacetylate it at Lysine 329, thereby increasing its enzymatic activity. | SIGNOR-267645 |
O15294 | P06737 | 1 | glycosylation | up-regulates activity | 0.2 | O-GlcNAcylation at Ser-430 promotes PYGL activity | SIGNOR-267988 |
P68400 | Q9Y5B0 | 1 | phosphorylation | down-regulates activity | 0.373 | We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities.| Phosphorylation of FCP1 by CK2 Inhibits the Transcription Elongation Activity of... | SIGNOR-250844 |
P56645 | P48730 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.719 | We show here that mPer proteins, negative limbs of the autoregulatory loop, are specific substrates for CKIepsilon and CKIdelta. The CKI phosphorylation of mPer1 and mPer3 proteins results in their rapid degradation, which is dependent on the ubiquitin-proteasome pathway. | SIGNOR-267998 |
Q9UK80 | Q16539 | 0 | phosphorylation | up-regulates activity | 0.253 | In this study, we found that USP21 is an important deubiquitinating enzyme for STING and that it negatively regulates the DNA virus-induced production of type I interferons by hydrolyzing K27/63-linked polyubiquitin chain on STING. HSV-1 infection recruited USP21 to STING at late stage by p38-mediated phosphorylation o... | SIGNOR-273670 |
P31749 | Q9BXL7 | 1 | phosphorylation | up-regulates activity | 0.522 | Akt phosphorylates S637 and S645 in the linker region of Carma1 | SIGNOR-276621 |
Q02880 | P48730 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Specifically, DNA damage signal, triggered by teniposide (VM-26) treatment, activates ATM, cooperating with CK1 to phosphorylate TOP2β on Ser1134 and Ser1130, respectively, in a canonical degron motif to facilitate β-TrCP binding and subsequent degradation.CK1 binds with and phosphorylates TOP2β at Ser1130 to promote i... | SIGNOR-277509 |
Q00653 | Q99558 | 0 | phosphorylation | up-regulates activity | 0.677 | NIK-induced p100 processing requires phosphorylation of p100 at serines 866 and 870 | SIGNOR-105553 |
P50552 | Q15418 | 0 | phosphorylation | down-regulates | 0.45 | Rsk1 phosphorylated vasp on t278, a site regulating its binding to actin. | SIGNOR-172899 |
P06493 | P17096 | 1 | phosphorylation | down-regulates | 0.384 | Here, we found that hipk2 phosphorylates hmga1a at ser-35, thr-52, and thr-77, and hmga1b at thr-41 and thr-66. In addition, we demonstrated that cdc2, which is known to phosphorylate hmga1 proteins, could induce the phosphorylation of hmga1 proteins at the same ser/thr sites. we found that the hipk2-phosphorylated hmg... | SIGNOR-158604 |
P12830 | P68400 | 0 | phosphorylation | up-regulates activity | 0.401 | Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion. | Under these conditions, phosphorylation of the E-cadherin double mutant S853A/S855A was reduced by 25% as compared with wt E-cadherin. | Expression of the E-cadherin double mutant S853A/S85... | SIGNOR-250840 |
P16157 | O00533 | 0 | relocalization | up-regulates quantity | 0.532 | Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with... | SIGNOR-266724 |
Q13507 | P17252 | 0 | phosphorylation | down-regulates | 0.348 | There are two known phosphorylation-mediated inactivation mechanisms for trpc3 channels. Protein kinase g (pkg) inactivates trpc3 by direct phosphorylation on thr-11 and ser-263 of the trpc3 proteins, and protein kinase c (pkc) inactivates trpc3 by phosphorylation on ser-712. | SIGNOR-130269 |
O14974 | Q13418 | 0 | phosphorylation | down-regulates activity | 0.584 | MYPT1 was phosphorylated by ILK and phosphorylation sites in the N- and C-terminal fragments of MYPT1 were detected. From sequence analyses, three sites were identified: a primary site at Thr(709), and two other sites at Thr(695) and Thr(495). ILK produced an intermediate level of inhibition | SIGNOR-262884 |
P23467 | P06213 | 1 | dephosphorylation | down-regulates | 0.344 | Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. | SIGNOR-75997 |
Q99816 | O60291 | 0 | monoubiquitination | up-regulates activity | 0.492 | In the present study, we identified the first substrate of the Mahogunin E3 ubiquitin–protein ligase: TSG101, a key component of the endosomal sorting ESCRT machinery.We find that Mahogunin interacts with the ubiquitin E2 variant (UEV) domain of TSG101 via its PSAP motif and that it catalyzes monoubiquitylation of TSG1... | SIGNOR-271635 |
Q5VTB9 | O75182 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.429 | Here we identify RNF220 (RING finger protein 220) as a novel ubiquitin ligase for Sin3B. RNF220 specifically interacts with Sin3B both in vitro and in vivo. Sin3B can be regulated by the ubiquitin-proteasome system. Co-expression of RNF220 promotes the ubiquitination and proteasomal degradation of Sin3B. | SIGNOR-271943 |
P31749 | P36776 | 1 | phosphorylation | up-regulates activity | 0.253 | In mitochondria, LonP1 is phosphorylated by Akt on Ser173 and Ser181, enhancing its protease activity. | SIGNOR-265724 |
Q05513 | P10636-2 | 1 | phosphorylation | down-regulates activity | 0.268 | We have studied the relationship between the phosphorylation oftau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. By contrast, MARK and PKA phosphorylate several sites within the repeats (notably theKXGS motifs including Ser262, Ser324, and Ser356, plus Ser320); in addition PKA phosphorylates so... | SIGNOR-275447 |
O15350 | P53350 | 0 | phosphorylation | down-regulates | 0.51 | P73-mediated transcriptional activity is negatively regulated by polo-like kinase 1. tap73 is phosphorylated by this kinase on threonine-27 (thr-27) within the ta domain. | SIGNOR-178253 |
P16220 | Q9Y243 | 0 | phosphorylation | up-regulates | 0.496 | When overexpressed in serum-stimulated cells, akt/pkb potently induced ser-133 phosphorylation of creb and promoted recruitment of cbp. | SIGNOR-62257 |
Q16512 | P06493 | 0 | phosphorylation | up-regulates activity | 0.436 | CDK1 phosphorylates PKN1 at S533, S537, S562, and S916 in vitro and in cells during drug-induced mitotic arrest. Immunofluorescence staining further confirmed that PKN1 phosphorylation occurs during normal mitosis in a CDK1-dependent manner.Knockdown of PKN1 significantly inhibited anchorage-independent growth and migr... | SIGNOR-276831 |
O14920 | Q15672 | 1 | phosphorylation | down-regulates activity | 0.332 | Hence, our current study supports the pivotal role of beta-TRCP in IKKbeta mediated Twist degradation.|More importantly, IKK\u03b2-dependent phosphorylation of Twist at T125 and S127 governs its nuclear localization. | SIGNOR-278404 |
P24928 | Q8IXW5 | 0 | dephosphorylation | up-regulates activity | 0.738 | In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Se... | SIGNOR-248748 |
Q9BWU1 | P46531 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.302 | Mapping of cyclin C-dependent phosphosites on ICN1, using mass spectrometry revealed that several of them are located within the PEST-domain of Notch1, which controls ICN1 degradation38,39 (Fig. 5g and Supplementary Table 1). Three of them (T2512, S2514 and S2517) are localized within the consensus motif, “Cdc4 phospho... | SIGNOR-273135 |
Q9Y4K4 | P49841 | 1 | phosphorylation | down-regulates | 0.2 | Gckr can phosphorylate an n-terminal recombinant fusion protein of gsk3_ and enhance the in vivo phosphorylation of gsk3_ on serine 9reduction of gckr expression inhibits wnt3a-induced phosphorylation of gsk3_ at serine 9 and decreases the accumulation of cytosolic _-catenin. | SIGNOR-148908 |
Q9UHC7 | P11940 | 1 | ubiquitination | up-regulates activity | 0.35 | We show that MKRN1 directly binds to the cytoplasmic poly(A)-binding protein (PABPC1) and associates with polysomes. MKRN1 is positioned upstream of poly(A) tails in mRNAs in a PABPC1-dependent manner. Ubiquitin remnant profiling and in vitro ubiquitylation assays uncover PABPC1 and ribosomal protein RPS10 as direct ub... | SIGNOR-272215 |
Q9HAW8 | Q99626 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.257 | Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. | SIGNOR-253968 |
Q12800 | P24941 | 0 | phosphorylation | down-regulates | 0.2 | In vitro, lsf is phosphorylated by cyclin e/cyclin-dependent kinase 2 (cdk2), cyclin c/cdk2, and cyclin c/cdk3, predominantly on s309. Phosphorylation by cyclin c/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of lsf during g1 progression | SIGNOR-184160 |
P68400 | P20042 | 1 | phosphorylation | up-regulates | 0.35 | The n-terminal domain of the human eif2beta subunit and the ck2 phosphorylation sites are required for its function. These results suggest that ser2 and ser67 contribute to the important role of the n-terminal region of eif2beta for its function in mammals. | SIGNOR-140994 |
P12931 | P46940 | 1 | phosphorylation | up-regulates activity | 0.695 | IQGAP1 was phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src signaling, including in human lung cancer cell lines. This phosphorylation was significantly reduced by chemical inhibitors of MET or c-Src or by siRNA-mediated knockdown of MET. | SIGNOR-277533 |
Q86YS7 | P31751 | 0 | phosphorylation | up-regulates activity | 0.513 | MS analysis of an HA-CDP138 sample from the in vitro kinase assay revealed that active Akt2 induces CDP138 phosphorylation at serine (Ser)197, which lies within a consensus Akt substrate motif RQRLIS 197 ( xref ). | SIGNOR-279585 |
P50750 | Q15596 | 1 | phosphorylation | up-regulates activity | 0.246 | Interestingly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 phospho-isoforms. Phosphorylation potentiates GRIP1 coactivator but, remarkably, not its corepressor proper... | SIGNOR-256098 |
O15054 | Q99814 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271586 |
Q8NEV1 | Q92915 | 1 | phosphorylation | up-regulates activity | 0.269 | Bioluminescence-based screening of small molecule modulators of the FGF14:Nav1.6 complex identified 4,5,6,7 -: tetrabromobenzotriazole (TBB), a potent casein kinase 2 (CK2) inhibitor, as a strong suppressor of FGF14:Nav1.6 interaction. Inhibition of CK2 through TBB reduces the interaction of FGF14 with Nav1.6 and Nav1.... | SIGNOR-275743 |
Q14774 | P49918 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | In this study, we have identified cell cycle regulatory genes as downstream targets of the homeobox gene HLX in cultured trophoblast cells, namely RB1, MYC, EGR1, CDKN1C, ELK1, CCNB1, and JUN. RB1 and MYC mRNA expression was increased with HLX inactivation, whereas EGR1, CDKN1C, ELK1, CCNB1, and JUN mRNA expression was... | SIGNOR-261620 |
P29597 | P17181 | 1 | phosphorylation | up-regulates activity | 0.91 | We demonstrate that, in vitro, p135tyk2 phosphorylates two tyrosines on IFNaR1. A phosphopeptide corresponding to the major phosphorylation site (Tyr466) binds STAT2, but not STAT1, in an SH-2-dependent manner. Furthermore, only latent, non-phosphorylated STAT2 interacts with this phosphopeptide. When this phosphopepti... | SIGNOR-246934 |
P13569 | Q9P0N8 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | A catalytically dead MARCH2 RING mutant was unable to promote CFTR degradation.|In vivo ubiquitination assays demonstrated the ubiquitination of CFTR by MARCH2, and overexpression of MARCH2, like that of CAL and STX6, led to a dose dependent degradation of mature CFTR that was blocked by bafilomycin A1 treatment. | SIGNOR-278584 |
Q14980 | P06493 | 0 | phosphorylation | down-regulates | 0.587 | Cdk1-mediated phosphorylation at t2055 negatively regulates numa cortical localization and that this phosphorylation is counteracted by ppp2ca phosphatase activity. | SIGNOR-194825 |
P00748 | P45452 | 0 | cleavage | down-regulates quantity by destabilization | 0.313 | The data presented in this study show for the first time the degradation of Factor XII of the blood clotting system by matrix metalloproteinases. MMP-12, MMP-13, and MMP-14 cleave at Gly376Leu377|However, no activity of Factor XII can be observed after MMPinduced cleavage. | SIGNOR-263609 |
P00533 | Q9UKV8 | 1 | phosphorylation | up-regulates activity | 0.534 | Furthermore, AGO2 function is directly modulated by EGFR signaling in ERalpha negative breast cancer under states of hypoxic stress.|Here, EGFR can directly bind and phosphorylate residue Y393 of AGO2[ xref ]. | SIGNOR-278931 |
O15530 | O00141 | 1 | phosphorylation | up-regulates activity | 0.65 | PDK1 activates SGK in vitro by phosphorylating Thr256. | SIGNOR-250275 |
P12931 | Q8WUM4 | 1 | phosphorylation | down-regulates activity | 0.393 | Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities. Phosphorylation of Alix by Src caused it to translocate from the membrane and cytoskeleton to the cytoplasm and reduced its interaction with binding partners SETA/CIN85, epidermal growth factor receptor, and... | SIGNOR-263201 |
P16298 | Q6VAB6 | 1 | dephosphorylation | up-regulates activity | 0.259 | These findings indicate that calcineurin modulates the phosphorylation state of KSR2, but not KSR1, and identifies S198, T287, and the S310 14-3-3 binding site as the KSR2 residues targeted by calcineurin.|the negative regulators 14-3-3 | SIGNOR-248381 |
P17676 | P35318 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.245 | These findings suggest that NF-IL6 and AP-2 sites in the promoter region are the functional elements in the transcriptional regulation of human AM gene in vascular endothelial cells. | SIGNOR-254047 |
Q13464 | O00429 | 1 | phosphorylation | up-regulates activity | 0.314 | We have also previously reported that ROCK1-mediated Drp1S600 phosphorylation resulted in enhanced mitochondrial fission in podocytes | SIGNOR-262549 |
Q96L34 | Q5BJF6 | 1 | phosphorylation | up-regulates activity | 0.516 | Collectively, our data indicate that MARK4 interacts with ODF2 in vivo and phosphorylates ODF2 in vitro.|Collectively, our data support the model that MARK4 promotes ciliogenesis by acting upstream of ODF2. | SIGNOR-278961 |
Q92804 | Q99873 | 0 | methylation | up-regulates | 0.431 | The methylation of taf15 by prmt1 is required for the ability of taf15 to positively regulate the expression of the studied endogenous taf15-target genes. | SIGNOR-183137 |
P41250 | P18848 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269426 |
Q99626 | Q16539 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.414 | ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation | SIGNOR-250092 |
Q8N122 | Q13131 | 0 | phosphorylation | down-regulates activity | 0.687 | Ampk in turn inactivates mtorc1 directly by phosphorylating raptor and indirectly by phosphorylating tsc2. | SIGNOR-173035 |
P68400 | P53539 | 1 | phosphorylation | up-regulates | 0.2 | Our findings indicate that ck2 activation increases deltafosb's transactivation potential, while ck2 inhibition decreases it. Further, we show that preventing ser27 phosphorylation by mutating the site to ala results in a significant decrease in deltafosb transactivation | SIGNOR-152403 |
P28482 | Q07820 | 1 | phosphorylation | up-regulates | 0.527 | We found that jnk phosphorylated ser-121 and thr-163 of mcl-1 in response to stimulation with h(2)o(2) and that transfection of unphosphorylatable mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with h(2)o(2). Jnk-dependent phosphorylation and thus inactivation of mcl-1 may be one of th... | SIGNOR-92593 |
Q16143 | P53350 | 0 | phosphorylation | down-regulates activity | 0.318 | Polo-like kinase (plk) family (plk1, plk2, and plk3) phosphorylate alpha-syn and beta-syn specifically at ser-129 and ser-118, respectively. Polo-like kinase 2 (plk2) phosphorylates alpha-synuclein at serine 129 in central nervous system. The membrane association of pd-linked mutant alpha -synuclein, but not wild-type ... | SIGNOR-176079 |
Q14680 | O43524 | 1 | phosphorylation | down-regulates quantity | 0.362 | Further analysis indicated that FOXO1 and FOXO3, two known transcriptional regulators of p21, were phosphorylated by MELK and thus be involved in the induction of p21 after MELK inhibition.|Our findings revealed that siRNA mediated MELK knockdown increased protein levels of FOXO1 and FOXO3, which might increase p21 tra... | SIGNOR-279375 |
P17252 | P60880 | 1 | phosphorylation | up-regulates | 0.353 | Phosphorylation of snap-25 at ser187 mediates enhancement of exocytosis by a phorbol ester in ins-1 cells. | SIGNOR-160313 |
Q8IWB6 | P53350 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.354 | We show that phosphorylation of Tex14 by Plk1 during metaphase is required for proteosome dependent degradation of Tex14 and transition from metaphase to anaphase. Phosphorylation of Tex14 Ser431 by Plk1 promotes Tex14 depletion. | SIGNOR-273529 |
Q9H3K2 | P99999 | 1 | relocalization | down-regulates quantity | 0.255 | MICS1 was clearly coprecipitated with cytochrome c-3FLAG and the amount was DSP concentration-dependent (Figure 6A). Together with the finding that overexpression of exogenous MICS1 delayed the apoptotic release of cytochrome c in normal-serum level medium (Figure 4A), these results suggest that MICS1 helps to retain c... | SIGNOR-260294 |
Q99873 | Q9UKM9 | 0 | post transcriptional regulation | up-regulates quantity | 0.247 | RALY binds poly-U rich elements within several RNAs and regulates the expression as well as the stability of specific transcripts. Here we show that RALY binds PRMT1 mRNA and regulates its expression.|We demonstrate that RALY down-regulation decreases protein arginine N-methyltransferase 1 levels | SIGNOR-262273 |
P40763 | P07332 | 0 | phosphorylation | up-regulates activity | 0.402 | Fes also induced Tyr 705 phosphorylation and DNA binding activity of STAT3, in agreement with the idea that Fes can regulate transcriptional activation through Fes dependent phosphorylation of transcription factors.On the basis of these findings, we propose that Fes activation of critical transcriptional regulators suc... | SIGNOR-278937 |
Q13131 | Q8ND76 | 1 | phosphorylation | up-regulates activity | 0.2 | Our in vitro and cellular analyses supported the mass spectrometry data that implicated serine 326 (S326) as the phospho-acceptor site on CCNY by AMPK. |Mechanistically the S326 phosphorylation by AMPK promotes the interaction of CCNY with CDK16, which in turn autophosphorylates S336, which serves as a marker for activ... | SIGNOR-273011 |
P24941 | Q13309 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.799 | The activity of SCF(Skp2) is regulated by the Cyclin-dependent kinase (CDK)2-mediated phosphorylation of Skp2 on Ser64 allows its expression in mid-G1 phase, even in the presence of active APC(Cdh1). Reciprocally, dephosphorylation of Skp2 by the mitotic phosphatase Cdc14B at the M --> G1 transition promotes its degrad... | SIGNOR-249173 |
P15172 | P53778 | 0 | phosphorylation | up-regulates activity | 0.446 | We determined that p38-gamma directly phosphorylated MyoD on Ser199 and Ser200, which results in enhanced occupancy of MyoD on the promoter of myogenin together with markedly decreased transcriptional activity. Phosphorylation of MyoD by p38-γ directs the assembly of a repressive transcriptional complex at the Myogeni... | SIGNOR-276273 |
P67809 | P28482 | 0 | phosphorylation | up-regulates activity | 0.47 | ERK2 may also directly phosphorylate YB-1 and therefore promotes its ability to transactivate target genes. | SIGNOR-279227 |
Q9UQC2 | A7KAX9 | 1 | relocalization | up-regulates | 0.374 | Gc-gap, a rho family gtpase-activating protein that interacts with signaling adapters gab1 and gab2we propose that gab1 and gab2 in cooperation with other adapter molecules might regulate the cellular localization of gc-gap under specific stimuli. | SIGNOR-102628 |
P15311 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.464 | Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. | SIGNOR-250665 |
P63244 | P00519 | 0 | phosphorylation | up-regulates | 0.2 | Phosphorylation of rack1 on tyrosine 52 by c-abl is required for insulin-like growth factor i-mediated regulation of focal adhesion kinase.Tyrosine 52 is further shown to be phosphorylated by c-abl kinase, and the c-abl inhibitor sti571 disrupts fak interaction with rack1 | SIGNOR-185649 |
Q01082 | P17612 | 0 | phosphorylation | down-regulates activity | 0.331 | Short C-terminal splice variant of betaII-spectrin (betaIISigma2) is a substrate for phosphorylation. protein kinase A phosphorylates Thr-2159. Mammalian alphaII- and betaII-spectrin subunits form dimers that associate head to head with high affinity to form tetramers In vitro, protein kinase A phosphorylation of an ... | SIGNOR-250054 |
Q12933 | Q9NQC7 | 0 | deubiquitination | down-regulates activity | 0.677 | Cyld also interacts directly with tumour-necrosis factor receptor (tnfr)-associated factor 2 (traf2), an adaptor molecule involved in by members of the family of tnf/nerve growth factor receptors. (articolo-abstract) | SIGNOR-117860 |
P21333 | P16298 | 0 | dephosphorylation | down-regulates quantity by destabilization | 0.2 | Filamin is a phosphoprotein that organizes actin filaments into networks. We report that a purified C-terminal recombinant region of filamin is a suitable substrate for calcineurin |Mutagenesis analysis showed that a dephosphorylation step occurred in Ser 2152, which was previously shown to provide resistance to calpai... | SIGNOR-248362 |
P48730 | P17252 | 0 | phosphorylation | up-regulates activity | 0.2 | In the present study we analyzed the CK1δ kinase domain for phosphorylation sites targeted by PKCα. Several phosphorylation sites were identified in vitro by initially using GST-CK1δ wild type and phosphorylation-site mutant protein fragments originating from the CK1δ kinase domain. Residues S53, T176, and S181 could f... | SIGNOR-277452 |
Q96EB6 | P17861-2 | 1 | deacetylation | down-regulates activity | 0.379 | P300 increases the acetylation and protein stability of XBP1s, and enhances its transcriptional activity, whereas SIRT1 deacetylates XBP1s and inhibits its transcriptional activity.. The mRNA encoding the active spliced form of XBP1 (XBP1s) is generated from the unspliced form by IRE1 (inositol-requiring enzyme 1) duri... | SIGNOR-260430 |
Q6ZMG9 | P68400 | 0 | phosphorylation | up-regulates activity | 0.2 | Most of the phosphorylated residues conformed to a consensus motif for phosphorylation by casein kinase 2 (CK2), and treatment of cells with the CK2-specific inhibitor CX-4945 lowered the phosphorylation levels of CERS2, -4, -5, and -6. Phosphorylation of CERS2 was especially important for its catalytic activity, actin... | SIGNOR-273992 |
P23458 | Q13261 | 0 | null | up-regulates | 0.462 | Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly ... | SIGNOR-256227 |
P23470 | O75553 | 1 | dephosphorylation | down-regulates activity | 0.2 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254697 |
P61586 | Q9P2F6 | 0 | gtpase-activating protein | down-regulates activity | 0.709 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260472 |
O60674 | Q92915 | 1 | phosphorylation | up-regulates activity | 0.2 | JAK2 regulates Nav1.6 channel function via FGF14Y158 phosphorylation|Patch-clamp electrophysiology revealed that through Y158, JAK2 controls FGF14-dependent modulation of Nav1.6 channels. In hippocampal CA1 pyramidal neurons, the JAK2 inhibitor Fedratinib reduced firing by a mechanism that is dependent upon expression ... | SIGNOR-275747 |
P17252 | Q12791 | 1 | phosphorylation | up-regulates | 0.2 | Results showed that mutating s1076 altered the effect of pkc activation on bk(ca) channels in hek-293 cells | SIGNOR-186755 |
P46531 | Q8IUQ4 | 0 | relocalization | up-regulates | 0.26 | The overexpression of siah1 causes the re-localization of notch from the cell surface to the cytoplasm and to the nucleus, which is indicative of notch activation | SIGNOR-168460 |
P53350 | P30622 | 1 | phosphorylation | up-regulates | 0.703 | Furthermore, we provide evidence that plk1 phosphorylation of clip-170 at s195 enhances its association with ck2 | SIGNOR-167172 |
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