IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
P62834 | Q92565 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.648 | We found here that cAMP-dependent activation of Epac1 and Rap1 but not PKA is able to activate CaMKI to mediate Ser47 (S47) phosphorylation in GCM1. Epac1 and Epac2 proteins were identified as cAMP-binding proteins with guanine nucleotide exchange factor (GEF) activities for the small GTPases, Rap1 and Rap2 | SIGNOR-262682 |
P03952 | P01042 | 1 | cleavage | up-regulates activity | 0.779 | Bradykinin is a nonapeptide composed of the sequence Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg and functions as an inflammatory mediator. BK is the product of the kallikrein–kinin system following activation of FXII. FXIIa leads to proteolysis of PK, and the resulting PKa cleaves HK to generate BK (Figure 1). | SIGNOR-263548 |
Q9Y3C5 | P31749 | 0 | phosphorylation | down-regulates quantity | 0.456 | Upon inhibition of the AKT pathway or mutation of T135, the phosphorylation at one of these sites is virtually eliminated, suggesting that AKT may phosphorylate RNF11 at T135. Moreover, RNF11 is phosphorylated by AKT in vitro and is recognized by phospho-AKT substrate antibodies. RNF11 shows enhanced binding to 14-3-3 ... | SIGNOR-252558 |
P10721 | P35232 | 1 | phosphorylation | up-regulates activity | 0.2 | In this study, we showed that c-Kit associates with PHB to upregulate phospho-PHB in the lipid raft of the plasma membrane.|c-Kit phosphorylates PHB at the Tyr259 residue. | SIGNOR-278362 |
P38398 | Q7Z6Z7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.397 | Collectively, these data indicate that HUWE1 targets BRCA1, but not BARD1, for polyubiquitination and degradation.Because HUWE1 promotes BRCA1 ubiquitination and degradation, we wondered whether it might contribute to the reduced BRCA1 protein levels in sporadic breast cancer. | SIGNOR-278583 |
Q9UPT5 | P28482 | 0 | phosphorylation | up-regulates | 0.331 | Erk1/2 phosphorylation enhances the binding of exo70 to other exocyst components and promotes the assembly of the exocyst complex in response to epidermal growth factor (egf) signaling. | SIGNOR-197543 |
Q07889 | P01111 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.78 | Sos and Ras-GRF are two families of guanine nucleotide exchange factors that activate Ras proteins in cells. Sos proteins are ubiquitously expressed and are activated in response to cell-surface tyrosine kinase stimulation Sos1 and Ras-GRF1 activate the Ras proteins Ha-Ras, N-Ras, and Ki-Ras | SIGNOR-110566 |
O60566 | P06493 | 0 | phosphorylation | up-regulates | 0.777 | Here, we demonstrate that bubr1 is phosphorylated on the cdk1 site t620, which triggers the recruitment of plk1 and phosphorylation of bubr1 by plk1 both in vitro and in vivo. Phosphorylation does not appear to be required for spindle checkpoint function but instead is important for the stability of kinetochore-microtu... | SIGNOR-157642 |
Q07812 | O60260 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | The E3 ligase parkin, which is known to trigger mitochondria specific autophagy, ubiquitylates BAX K128 and targets the pro apoptotic BCL-2 protein for proteasomal degradation. | SIGNOR-278529 |
P33176 | Q9NX95 | 1 | relocalization | up-regulates activity | 0.56 | Conventional kinesin I heavy chain binds to syntabulin and associates with syntabulin-linked syntaxin vesicles in vivo. These findings suggest that syntabulin functions as a linker molecule that attaches syntaxin-cargo vesicles to kinesin I, enabling the transport of syntaxin-1 to neuronal processes. | SIGNOR-264811 |
Q16539 | P42574 | 1 | phosphorylation | down-regulates | 0.775 | Consequently, p38-mapk can directly phosphorylate and inhibit the activities of caspase-8 and caspase-3 and thereby hinder neutrophil apoptosis, and, in so doing, regulate the inflammatory response. | SIGNOR-122099 |
Q15653 | Q15418 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.369 | By using recombinant wild-type and mutant IkappaBbeta proteins, both active ERK2 and RSK1 were found to directly phosphorylate IkappaBbeta, but only active RSK1 phosphorylated IkappaBbeta on Ser19 and Ser23, two sites known to mediate the subsequent ubiquitination and degradation. | SIGNOR-280114 |
P24071 | P67775 | 0 | dephosphorylation | up-regulates activity | 0.323 | Furthermore, FcalphaRI activation is induced by protein phosphatase 2A (PP2A) after it dephosphorylates a single serine residue (S263) in the FcalphaRI intracellular tail | SIGNOR-264858 |
Q8NBJ5 | P02461 | 1 | glycosylation | up-regulates activity | 0.404 | Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxyly... | SIGNOR-261154 |
P42224 | P49336 | 0 | phosphorylation | up-regulates activity | 0.392 | We previously demonstrated that Mediator kinase inhibitor cortistatin A (CA) reduced proliferation of JAK2-mutant AML in vitro and in vivo and also suppressed CDK8-dependent phosphorylation of STAT1 at serine 727. Here we report that phosphorylation of STAT1 S727 promotes the proliferation of AML cells with JAK-STAT pa... | SIGNOR-273179 |
P12931 | O14578 | 1 | phosphorylation | up-regulates activity | 0.273 | CitK is tyrosine phosphorylated by Src in response to EphB2 signaling. | SIGNOR-279484 |
P16104 | Q14493 | 0 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265405 |
O15111 | P31749 | 0 | phosphorylation | up-regulates | 0.668 | Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosph... | SIGNOR-187006 |
P23458 | P29597 | 1 | phosphorylation | up-regulates | 0.527 | These results indicate that tyk2 is activated by phosphorylation on tyr-1054 and/or tyr-1055 and that this phosphorylation requires another kinase, most likely jak1. | SIGNOR-43080 |
P05549 | P68400 | 0 | phosphorylation | up-regulates | 0.307 | Ck2 phosphorylates ap-2_ and increases its transcriptional activity | SIGNOR-175130 |
P98177 | P24941 | 0 | phosphorylation | down-regulates | 0.518 | Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity | SIGNOR-183655 |
Q06124 | P46527 | 1 | dephosphorylation | up-regulates activity | 0.281 | Moreover, SHP-2 was strongly activated on G-CSF stimulation and specifically dephosphorylated p27(Kip1) in vitro.|Most importantly, we could illustrate that SHP-2 modulates p27 (Kip1) stability and contributes to p27 (Kip1)-mediated cell cycle progression. | SIGNOR-277168 |
Q16236 | P15559 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.487 | In both models, the inducer-modified and Nrf2-bound Keap1 is inactivated and, consequently, newly synthesized Nrf2 proteins bypass Keap1 and translocate into the nucleus, bind to the ARE and drive the expression of Nrf2 target genes such as NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HMOX1), glutamate-cy... | SIGNOR-256275 |
O14965 | Q02224 | 1 | phosphorylation | down-regulates activity | 0.48 | Aurora A also phosphorylates and inhibits the centromere-associated kinesin CENP-E involved in efficient chromosome congression ( xref ; xref ). | SIGNOR-280187 |
P53778 | O15297 | 0 | dephosphorylation | down-regulates | 0.297 | Ppm1d selectively inhibits p38 activation by dephosphorylating thr 180. | SIGNOR-135976 |
O75030 | P78527 | 0 | phosphorylation | up-regulates activity | 0.2 | These results suggest that DNA-PK can target MITF-S325 for phosphorylation. In melanocytes and melanoma cells, MITF is rapidly phosphorylated by DNA-PK and interacts with NBS1–RAD50 but not MRE11, destabilizing the MRN complex. | SIGNOR-277899 |
P04792 | P31749 | 0 | phosphorylation | down-regulates | 0.66 | First, the akt1, akt2, and akt3 isoforms can bind directly to hsp27 and can be found in a complex with p38 mapk, mk2, and hsp27 [98_100]. Second, rane and colleagues showed that akt could phosphorylate hsp27 at ser-82, but not ser-15 or ser-78, in vitro, while co-expression of an active akt mutant and hsp27 in hek cell... | SIGNOR-252526 |
Q9BV47 | Q13158 | 1 | dephosphorylation | down-regulates activity | 0.366 | This multi-functionality of fadd may depend primarily on its subcellular location. Fadd shuttles between the cytosol and the nucleus and this signal is unclear;however, fadd trafficking requires phosphorylation of the protein on ser194dusp26 suppresses cell proliferation by fadd dephosphorylation | SIGNOR-204559 |
Q05655 | P30411 | 1 | phosphorylation | down-regulates activity | 0.301 | In addition, we found a protein kinase C-dependent phosphorylation of Ser(346) that was mutually exclusive with the basal phosphorylation at Ser(348) and therefore may be implicated in differential regulation of B2 receptor activation. Functional analysis of receptor mutants revealed that a low phosphorylation stoichio... | SIGNOR-249108 |
P56750 | Q8TBB1 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.294 | We used the Ligand of Numb protein X (LNX) family of E3s, a group of PDZ domain-containing RING-type E3 ubiquitin ligases, to demonstrate the feasibility of this strategy. Many potential substrates of LNX E3s were identified. Eight of the nine selected candidates were ubiquitinated in vitro, and two novel endogenous su... | SIGNOR-272900 |
P28482 | P53805 | 1 | phosphorylation | up-regulates activity | 0.27 | Consensus phosphorylation sites for p42/44 MAPK and GSK-3 are present in the SP repeat of MCIP1 at serine 112 and serine 108, respectively |Several endogenous proteins are capable of inhibiting the catalytic activity of calcineurin. Modulatory calcineurin interacting protein 1 (MCIP1) is unique among these proteins on ... | SIGNOR-249198 |
P23470 | P06213 | 1 | dephosphorylation | up-regulates activity | 0.365 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254703 |
P61586 | P85298 | 0 | gtpase-activating protein | down-regulates activity | 0.427 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260463 |
P49715 | P04150 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.455 | We show that in addition, DEX-bound GR directly promotes the expression of adipogenic TFs, including C/EBPβ, Klf5, Klf9, and C/EBPα | SIGNOR-256116 |
P07585 | P09237 | 0 | cleavage | down-regulates quantity by destabilization | 0.61 | Degradation of decorin by matrix metalloproteinases. These data indicate proteolytic degradation of DCN by MMP-2, MMP-3 and MMP-7, and suggest the possibility that, under pathophysiological conditions, the digestion by the MMPs may induce tissue reactions mediated by TGF-beta1 released from DCN in the connective tissu... | SIGNOR-256352 |
P43405 | Q92918 | 1 | phosphorylation | up-regulates activity | 0.348 | BCR ligation induced rapid tyrosine-phosphorylation of HPK1 mainly by Syk and Lyn, resulting in its association with BASH and catalytic activation. BCR-mediated activation of HPK1 was impaired in Syk- or BASH-deficient B cells. The functional SH2 domain of BASH and Tyr-379 within HPK1 which we identified as a Syk-phosp... | SIGNOR-246567 |
P40763 | Q02156 | 0 | phosphorylation | up-regulates | 0.399 | Abrogation of pkcdelta activity inhibited insulin-induced stat3 phosphorylation, pkcdelta-stat3 association and nuclear translocation. | SIGNOR-143832 |
Q9UBP6 | Q15418 | 0 | phosphorylation | down-regulates | 0.324 | Pkb and ribosomal s6 kinase (rsk) both phosphorylated mettl1 at ser27 in vitro. | SIGNOR-135948 |
Q969H0 | Q5VWQ8 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.327 | DAB2IP protein levels can be negatively regulated by the activity of the E3-ubiquitin ligases Fbw7, Skp2, and Smurf1 | SIGNOR-254774 |
Q9BZE0 | P17612 | 0 | phosphorylation | down-regulates activity | 0.283 | Protein kinase a (pka) and glycogen synthase kinase 3beta sequentially phosphorylate gli2 at multiple sites, identified by mutagenesis, thus resulting in a reduction of its transcriptional activity | SIGNOR-145131 |
P42345 | P03372 | 1 | phosphorylation | up-regulates activity | 0.498 | Thus our results indicate that the interaction between ER\u03b1 and raptor is necessary to recruit raptor to the nucleus, where mTOR phosphorylates and activates ER\u03b1. | SIGNOR-278295 |
P33981 | P21589 | 1 | phosphorylation | up-regulates activity | 0.2 | Intermolecular NTE phosphorylation by Mps1 requires a topology in which sites proximal to the NTE interact with the active Mps1 in order to promote phosphorylation. | SIGNOR-280157 |
P15036 | O15550 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Our findings reveal a dual role for UTX in suppressing acute myeloid leukaemia via repression of oncogenic ETS and upregulation of tumor suppressive GATA programs. several ETS transcription factors, including Elf4, Etv6, Erg, Fli1, Ets2, Spi1 and Elk3 were upregulated immediately after Utx loss in the preleukaemic phas... | SIGNOR-260035 |
Q13153 | P18669 | 1 | phosphorylation | down-regulates | 0.2 | Activated pak1 inhibits glycolysis by association of its catalytic domain with pgam-b and subsequent phosphorylation of the enzyme on serine residues 23 and 118, thereby abolishing pgam activity. | SIGNOR-91594 |
P42345 | Q8N122 | 1 | phosphorylation | up-regulates activity | 0.989 | The phosphorylation of raptor is stimulated by insulin and inhibited by rapamycin. Importantly, the site-directed mutation of raptor at one phosphorylation site, Ser(863), reduced mTORC1 activity both in vitro and in vivo. | SIGNOR-184959 |
P63000 | O43295 | 0 | gtpase-activating protein | down-regulates activity | 0.566 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260518 |
P51813 | Q05397 | 1 | phosphorylation | up-regulates | 0.551 | Bmx phosphorylated focal adhesion kinase (fak) at tyr577 subsequent to its src-mediated phosphorylation at tyr576. Loss of bmx by rna interference or by genetic deletion in mouse embryonic fibroblasts (mefs) markedly impaired fak activity. | SIGNOR-202139 |
Q14774 | P19419 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | In this study, we have identified cell cycle regulatory genes as downstream targets of the homeobox gene HLX in cultured trophoblast cells, namely RB1, MYC, EGR1, CDKN1C, ELK1, CCNB1, and JUN. RB1 and MYC mRNA expression was increased with HLX inactivation, whereas EGR1, CDKN1C, ELK1, CCNB1, and JUN mRNA expression was... | SIGNOR-261622 |
P49841 | Q96RR4 | 1 | phosphorylation | down-regulates | 0.272 | Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. | SIGNOR-198134 |
P42262 | P51608 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.323 | Bicuculline treatment also leads to an increase in the levels of the transcriptional repressor MeCP2, which binds to the GluR2 promoter along with the corepressors HDAC1 and mSin3A. | SIGNOR-264684 |
P46531 | O14672 | 0 | cleavage | up-regulates activity | 0.782 | ADAM10-mediated Notch1 cleavage is the rate limiting-step for release of the NICD and subsequent activation of Notch1 signaling. In T cells ADAM10-mediated Notch1 shedding controls T cell development | SIGNOR-259838 |
Q15139 | Q96P20 | 1 | phosphorylation | up-regulates activity | 0.332 | PKD at the Golgi phosphorylates NLRP3 to release it from mitochondria-associated endoplasmic reticulum membranes, allowing for assembly of the mature inflammasome in the cytosol.|These data thus suggest that PKD activity at the Golgi is sufficient to activate the NLRP3 inflammasome. | SIGNOR-279428 |
Q96EB6 | O75376 | 1 | null | up-regulates | 0.621 | In differentiated adipocyte cell lines, SIRT1 inhibits adipogenesis and enhances fat mobilization through lipolysis by suppressing the activity of PPARγ. SIRT1 achieves this by promoting the assembly of a corepressor complex, involving NCoR1 and SMRT, on the promoters of PPARγ target genes to repress their transcriptio... | SIGNOR-253505 |
P08123 | P03956 | 0 | cleavage | down-regulates quantity by destabilization | 0.401 | In vitro, MMP1 initiates degradation of native fibrillar collagens, crucial components of vertebrate extracellular matrix (ECM), by cleaving the peptide bond between Gly775–Ile776 or Gly775–Lys776 in native type I, II or III collagen molecules3,4. | SIGNOR-272337 |
P42858 | Q9UHD2 | 0 | phosphorylation | up-regulates activity | 0.289 | Herein, we report the discovery and validation of a kinase, TANK-binding kinase 1 (TBK1), that efficiently phosphorylates full-length and N-terminal HTT fragments in vitro (at S13/S16), in cells (at S13) and in vivo. TBK1 expression in HD models (cells, primary neurons, and Caenorhabditis elegans) increases mutant HTT ... | SIGNOR-270350 |
Q01094 | Q13490 | 0 | ubiquitination | up-regulates activity | 0.336 | The ability of cIAP1 to promote wt E2F1 transcriptional activity was retained by all E2F1 mutants, except the K161R/164R mutant for which cIAP1 was completely inactive and the K185R whose basal transactivation activity was weakly enhanced by cIAP1 (XREF_FIG).|Here, we demonstrated that the E3-ubiquitin ligase cellular ... | SIGNOR-278688 |
Q15139 | Q9Y5P4 | 1 | phosphorylation | down-regulates | 0.2 | In this study, we identify cert as a novel in vivo pkd substrate. Phosphorylation on serine 132 by pkd decreases the affinity of cert toward its lipid target phosphatidylinositol 4-phosphate at golgi membranes and reduces ceramide transfer activity | SIGNOR-156500 |
P15173 | P38936 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.331 | P21 is regulated by MyoD and myogenin in normal muscle cells and the inactivation of these factors in RMS cells contributes to the silencing of p21 in RMS cells | SIGNOR-251575 |
P54132 | Q13535 | 0 | phosphorylation | up-regulates activity | 0.852 | It is noteworthy that an active BLM seems to be unnecessary to the activation of BRCA1, either after gamma-rays or HU, even though BRCA1 and BLM helicase are activated by ATR in response to stalled replication, and despite the fact that they colocalize after replication arrest.|These results show that BLM phosphorylati... | SIGNOR-278978 |
Q9BZ95 | Q14653 | 1 | methylation | up-regulates activity | 0.2 | We found that lysine methyltransferase NSD3 interacts with and directly monomethylates IRF3 in the nucleus, leading to the enhanced IRF3 transcriptional activity and antiviral immune responses. | SIGNOR-259198 |
A6NLU0 | P14635 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.32 | We conclude that, like many RING-finger containing proteins, RFPL4 is an E3 ubiquitin ligase. The specificity of its expression and these interactions suggest that RFPL4 targets cyclin B1 for proteasomal degradation, a key aspect of oocyte cell cycle control during meiosis and the crucial oocyte-to-embryo transition to... | SIGNOR-271476 |
P04626 | Q96JA1 | 0 | ubiquitination | down-regulates | 0.403 | We report upregulation of lrig1 transcript and protein upon egf stimulation, and physical association of the encoded protein with the four egfr orthologs of mammals. Upregulation of lrig1 is followed by enhanced ubiquitylation and degradation of egfr. The underlying mechanism involves recruitment of c-cbl, an e3 ubiqui... | SIGNOR-139948 |
Q9H8S9 | Q13188 | 0 | phosphorylation | up-regulates | 0.85 | Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. | SIGNOR-175809 |
O00755 | P09238 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | We first proved that Wnt7a activated the canonical Wnt pathway through direct regulation of the MMP10 gene. | SIGNOR-278867 |
O95997 | P49841 | 0 | phosphorylation | down-regulates activity | 0.2 | Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1 and human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors.|Here, we demonstrate that glycogen synthase kinase-3\u03b2 (GSK3\u03b2) phosphorylates securin to promote its proteolysis via SCF(\u0... | SIGNOR-279188 |
P06493 | Q9NXR1 | 1 | phosphorylation | up-regulates activity | 0.654 | We found that Nudel and NudE were also phosphorylated in M phase (Fig. (Fig.22 and and3).3). First, Nudel and NudE were specifically phosphorylated in M phase. Moreover, both proteins were phosphorylated by Cdc2 and Erk2 in vitro.Due to conservation of the S/TP motifs, NudE may also be phosphorylated at similar sites... | SIGNOR-274077 |
O75676 | P16220 | 1 | phosphorylation | up-regulates | 0.605 | Msk1 and msk2 directly phosphorilate and activete transcription factors such as creb1, atf1 msk was the kinase responsible for phosphorylation of the transcription factor creb in response to tcr stimulation. | SIGNOR-157158 |
O75030 | Q15661 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | The transcription of tryptase gene in human mast cells is regulated by mi transcription factor |Using mutant constructs of tryptase promoter, we observed that two E-box (CANNTG) motifs including between -817 to -715 and -421 to -202 are able to involve in the transactivation of tryptase gene by MITF-A. | SIGNOR-251725 |
Q9BXK1 | P12931 | 0 | phosphorylation | up-regulates activity | 0.245 | We further confirmed that the Tyr-10 residue of KLF16 is phosphorylated in uterine cells (Fig. 7c). Additional experiments using both pharmacological and dominant negative inhibitors of Src further supported a role for this tyrosine kinase in modulating the activity of KLF16 (Fig. 7, d and f). | SIGNOR-276398 |
P29353 | Q9UM73 | 0 | phosphorylation | up-regulates | 0.456 | Anaplastic lymphoma kinase (alk), which turned out to be one of these phosphoproteins, was constitutively activated and associated with the ptb domain of shcc in three neuroblastoma cells. In vitro kinase assay revealed that shcc is a potent substrate of the activated alk kinase. The alk gene locus was significantly am... | SIGNOR-91534 |
P01100 | P28482 | 0 | phosphorylation | up-regulates activity | 0.792 | We have recently shown that erk phosphorylates multiple residues within the carboxylterminal transactivation domain (tad) of c-fos, thus resulting in its increased transcriptional activity. ERK2 phosphorylated c-Fos TADs that included Thr- 325, Thr-331, or Ser-374 as unique phospho-acceptor sites, thus indicating that ... | SIGNOR-236010 |
Q8WWN8 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.47 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260456 |
Q8TDC3 | P30305 | 1 | phosphorylation | down-regulates | 0.506 | Hssad1 specifically phosphorylated wee1a, cdc25-c, and -b on ser-642, ser-216, and ser-361 in vitro, respectivelyphosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3 | SIGNOR-124839 |
P08559 | P12931 | 0 | phosphorylation | down-regulates activity | 0.348 | Src inactivated PDH through direct phosphorylation of tyrosine-289 of PDH E1α subunit (PDHA1). | SIGNOR-277204 |
Q13153 | Q12778 | 1 | phosphorylation | down-regulates activity | 0.358 | Pak1 efficiently phosphorylated GST-FKHR. | SIGNOR-279242 |
Q9P286 | P15976 | 1 | phosphorylation | up-regulates activity | 0.2 | In addition, we defined GATA1 Ser161, Ser187 were the main phosphorylation sites by PAK5. | SIGNOR-278297 |
P28482 | P11362 | 1 | phosphorylation | down-regulates | 0.309 | Erk-mediated phosphorylation of fibroblast growth factor receptor 1 on ser777 inhibits signaling | SIGNOR-200880 |
Q9P286 | Q9ULA0 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | We show that PAK5 interacts with and phosphorylates DNPEP at serine 119. | PAK5 decreases DNPEP abundance via the ubiquitin-proteasome pathway. | SIGNOR-275651 |
Q99638 | P00519 | 0 | phosphorylation | up-regulates activity | 0.477 | The SH3 domain of c-Abl interacts directly with the C-terminal region of Rad9. c-Abl phosphorylates the Rad9 Bcl-2 homology 3 domain (Tyr-28) in vitro and in cells exposed to DNA-damaging agents. | c-Abl-mediated phosphorylation of Rad9 induces binding of Rad9 to Bcl-xL |these findings indicate that Rad9 is regulated b... | SIGNOR-260843 |
P06241 | Q96J02 | 1 | phosphorylation | down-regulates activity | 0.366 | Tyrosine phosphorylation of Itch appears to reduce its interaction with its substrate JunB. The turnover of JunB is accelerated in Fyn-deficient T cells, which is further reconstituted by Itch Tyr371 mutation | SIGNOR-245332 |
Q9NRC8 | Q5TEC6 | 1 | deacetylation | up-regulates activity | 0.2 | Besides confirming the previously reported histone H3K18 deacylation activity, our results revealed that SIRT7 has an astonishingly high activity to catalyze deacylation of H3K36 and is also catalytically active to deacylate H3K37. | SIGNOR-275883 |
P53041 | P48730 | 0 | phosphorylation | up-regulates activity | 0.333 | Here, we show an "on/off switch" mechanism for PP5 regulation. The casein kinase 1δ (CK1δ) phosphorylates T362 in the catalytic domain of PP5, which activates and enhances phosphatase activity independent of Hsp90. | SIGNOR-277373 |
P46531 | P51608 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.29 | As the first step to reveal how MeCP2 phosphorylation may regulate Notch signaling, we conducted chromatin immunoprecipitation (ChIP) experiment to determine whether the phosphor-mutant MeCP2 protein has altered promoter occupancy at the promoters of Dll1 and Notch1. We found increased binding of the phosphor-mutant pr... | SIGNOR-264675 |
P98171 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.479 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260460 |
P46531 | Q92993 | 0 | acetylation | down-regulates | 0.414 | This result implies that the residues k2019, k2039, k2044, and k2068 of notch1-ic are the major targets of the acetyltransferase activity of tip60. | SIGNOR-156923 |
P08581 | P17252 | 0 | phosphorylation | down-regulates | 0.256 | These data show that phosphorylation of ser985 is a key mechanism for the negative regulation of hgf/sf receptor. | SIGNOR-37718 |
O75676 | P18846 | 1 | phosphorylation | up-regulates | 0.615 | Msk1 and msk2 directly phosphorilate and activate transcription factors such as creb1, atf1. | SIGNOR-116252 |
P68400 | P18887 | 1 | phosphorylation | up-regulates | 0.395 | Xrcc1 phosphorylation by ck2 is required for its stability and efficient dna repair | SIGNOR-165419 |
Q92786 | Q9Y478 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Furthermore, the Ser79 phosphorylation of PROX1 by AMPK enhances the recruitment of CUL4-DDB1 ubiquitin ligase to promote PROX1 degradation. | SIGNOR-277609 |
P26651 | Q16539 | 0 | phosphorylation | down-regulates activity | 0.357 | TTP appears to be a p38α/β MAPK target and pretreating skeletal muscle with a p38α/β MAPK inhibitor reduces TTP phosphorylation. | SIGNOR-253596 |
Q5S007 | P61020 | 1 | phosphorylation | up-regulates activity | 0.599 | Using recombinant proteins, we show here that LRRK2 phosphorylates Rab5b at its Thr6 residue in in vitro kinase assays with mass spectrophotometry analysis. Phosphorylation of Rab5b by LRRK2 on the threonine residue was confirmed by western analysis using cells stably expressing LRRK2 G2019S. The phosphomimetic T6D mu... | SIGNOR-276873 |
P48436 | P17612 | 0 | phosphorylation | up-regulates | 0.465 | We find that activation of camp-dependent protein kinase a (pka) induces phosphorylation of sox9 on its two s64 and s181 pka sites, and its nuclear localization by enhancing sox9 binding to the nucleocytoplasmic transport protein importin beta. | SIGNOR-137085 |
P17612 | Q14643 | 1 | phosphorylation | down-regulates activity | 0.556 | IP(3)R-I was phosphorylated by PKA and PKG in vitro and exclusively by PKG in vivo. Sequential phosphorylation by PKA and by PKG-Ialpha in vitro showed that PKA phosphorylated the same site as PKG (presumably S(1755)) and an additional PKA-specific site (S(1589)). Phosphorylation of IP(3)R-I in microsomes by PKG, PKA, ... | SIGNOR-249996 |
P35790 | Q99541 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | In addition, as a protein kinase, CHKalpha2 phosphorylates PLIN2 at Tyrosine 232 and PLIN3 at Tyrosine 251. Phosphorylated PLIN2 and PLIN3 are separated from lipid droplets and degraded by Hsc70-mediated autophagy, thereby promoting lipid droplet lipolysis, fatty acid oxidation and glioblastoma growth | SIGNOR-267649 |
P00519 | P18206 | 1 | phosphorylation | up-regulates activity | 0.38 | Abl is the tyrosine kinase that phosphorylates vinculin Y822.|Finally we show that Abl inhibition prevents vinculin actions in cadherin containing complexes, resulting in defects in cell stiffening. | SIGNOR-278464 |
P55283 | P63000 | 1 | null | up-regulates activity | 0.273 | Together, these data suggest that R-cadherin expression inhibits myogenesis and induces myoblast transformation through Rac1 activation. Therefore, the properties of R-cadherin make it an attractive target for therapeutic intervention in RMS. | SIGNOR-253103 |
Q15797 | Q9HCE7 | 0 | ubiquitination | down-regulates | 0.708 | Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps | SIGNOR-195660 |
P30291 | O43660 | 1 | phosphorylation | down-regulates activity | 0.2 | These results indicate that WEE1 promotes PRL1 phosphorylation.|WEE1 promotes PRL1 degradation . | SIGNOR-279579 |
P29597 | Q14765 | 1 | phosphorylation | up-regulates activity | 0.656 | IL-12 activates the Janus family tyrosine kinases JAK2 and Tyk2, which in turn phosphorylate STAT4 on tyrosine 693. | SIGNOR-279303 |
P50613 | P03372 | 1 | phosphorylation | up-regulates | 0.413 | Activation of estrogen receptor alpha by s118 phosphorylation involves a ligand-dependent interaction with tfiih and participation of cdk7. | SIGNOR-81170 |
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