IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
O60260 | Q8IWA4 | 1 | ubiquitination | down-regulates quantity | 0.2 | Parkin and PINK1 are required for ubiquitination of MFN-1 and MFN-2. Decreases in MFN-1 and MFN-2 protein levels seen at later timepoints are difficult to interpret as it is unclear whether this is due to degradation by the proteasome and/or loss of whole mitochondria by mitophagy. | SIGNOR-272779 |
P12931 | P25098 | 1 | phosphorylation | up-regulates activity | 0.2 | Here, we demonstrate that c-Src kinase activity increases the interaction between GRK2 and Galphaq. Tyrosine phosphorylation of GRK2 appears to be critically involved in the modulation of this interaction since the stimulatory effect of c-Src is not observed with a GRK2 mutant with impaired tyrosine phosphorylation (GR... | SIGNOR-266305 |
Q9NRR4 | P49841 | 0 | phosphorylation | up-regulates activity | 0.278 | Our findings suggest that phosphorylation of Drosha at multiple sites including S300 promotes its translocation to the cytoplasm. Interestingly, GSK3beta can phosphorylate Drosha at S300 and S302 in vitro. This has been reported to promote the nuclear localization of Drosha under basal condition (Tang et al., 2011). Th... | SIGNOR-264846 |
P00533 | Q9Y6I3 | 0 | relocalization | down-regulates | 0.596 | Epsin 1 is involved in recruitment of ubiquitinated egf receptors into clathrin-coated pits this supports the contention that epsin 1 promotes endocytosis of the ubiquitinated egfr. | SIGNOR-182562 |
P45985 | P45984 | 1 | phosphorylation | up-regulates | 0.729 | Mkk4, which activates p38gamma, p38delta, and jnk2 to phosphorylate p53 on ser-33 and cause a transient g(1) arrest. A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-... | SIGNOR-197998 |
O94901 | P53350 | 0 | phosphorylation | down-regulates activity | 0.453 | Here, we show that SUN1, located in the INM, undergoes mitosis-specific phosphorylation on at least 3 sites within its nucleoplasmic N-terminus. We further identify Cdk1 as the kinase responsible for serine 48 and 333 phosphorylation, while serine 138 is phosphorylated by Plk1. Together, these data support a model wher... | SIGNOR-263098 |
Q9P1A6 | Q9UPX8 | 1 | relocalization | up-regulates activity | 0.849 | SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK prot... | SIGNOR-264590 |
P03372 | P06239 | 0 | phosphorylation | up-regulates | 0.382 | On the basis of these data and other reports describing the structure and activity of y537 mutations, as well as knowledge of the three-dimensional structure of the her ligand binding domain, we propose an alternate model wherein y537f mutation favors an open pocket conformation, affecting the estrogen binding kinetics... | SIGNOR-55853 |
F7VJQ1 | Q00535 | 0 | phosphorylation | up-regulates quantity | 0.332 | Cdk5 phosphorylated PrP induces the aggregation of non phosphorylated PrP.|Together, these results indicate that S43 is a major Cdk5 phosphorylation site in PrP. | SIGNOR-278920 |
P01133 | O14672 | 0 | cleavage | up-regulates activity | 0.566 | Like ADAM17, ADAM10 has also been implicated in the activation of specific EGFR ligands, especially EGF and betacellulin | SIGNOR-259840 |
Q13017 | Q13882 | 0 | phosphorylation | up-regulates | 0.2 | Breast tumor kinase phosphorylates p190rhogap to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. Brk phosphorylates p190 at the y(1105) residue both in vitro and in vivo, thereby promoting the association of p190 with p120rasgap (p120). As a consequence, brk stimulates p190 and attenu... | SIGNOR-181452 |
P10914 | Q00987 | 0 | ubiquitination | down-regulates quantity | 0.388 | HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation.|IRF-1 ubiquitination by HDM2 is specifically increased during HIV-1 infection in the presence of increasing amounts of Tat and is mediated by the formation of a trimeric complex between Tat, IRF-1, and HDM2, as demonstrate... | SIGNOR-278590 |
Q9HD90 | Q9HCK8 | 0 | transcriptional regulation | down-regulates quantity | 0.2 | Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and... | SIGNOR-268918 |
P09630 | O15550 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.26 | Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. | SIGNOR-260028 |
Q15139 | Q9UQL6 | 1 | phosphorylation | down-regulates activity | 0.516 | Here, we demonstrate that signaling by protein kinase C (PKC) is sufficient and, in some cases, necessary to drive nuclear export of class II HDAC5 in cardiomyocytes. | SIGNOR-249270 |
Q96EB6 | Q13043 | 0 | phosphorylation | down-regulates activity | 0.344 | We found that MST1 increases p53 acetylation and transactivation by inhibiting the deacetylation of Sirtuin 1 (Sirt1) and its interaction with p53 and that Sirt1 can be phosphorylated by MST1 leading to the inhibition of Sirt1 activity. | SIGNOR-279574 |
Q09472 | P52292 | 1 | acetylation | up-regulates | 0.357 | Ampk triggered the acetylation of importin alpha1 on lys(22), a process dependent on the acetylase activity of p300 | SIGNOR-128625 |
P48058 | P05129 | 0 | phosphorylation | up-regulates | 0.702 | We found that pka phosphorylation of the ampa receptor subunits glur4 and glur1 directly controlled the synaptic incorporation of ampa receptors in organotypic slices from rat hippocampus. | SIGNOR-97558 |
P10915 | P09238 | 0 | cleavage | down-regulates quantity by destabilization | 0.323 | Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein. Sequencing studies of modified link protein components revealed that stromelysins-1 and -2, gelatinases A and B and collagenase cleaved specifically between His16 and Ile17, and matrilysin, stromelysin-2 and gelatinase A cleaved bet... | SIGNOR-256332 |
P05198 | P49770 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.802 | EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. | SIGNOR-269125 |
Q9P275 | P04179 | 1 | deubiquitination | up-regulates quantity by stabilization | 0.319 | Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36|Finally, USP36 was shown to be a specific deubiquitinating enzyme that reduces the ubiquitination level of SOD2 and was involved in SOD2 protein stability by extending its half-life. | SIGNOR-272280 |
Q969H0 | Q9NYY3 | 0 | phosphorylation | down-regulates | 0.483 | Plk2 regulates centriole duplication through phosphorylation-mediated degradation of fbxw7 (human cdc4).Plk2 phosphorylates fbxw7 on serine 176 | SIGNOR-196448 |
P31749 | P49760 | 1 | phosphorylation | up-regulates | 0.39 | Akt directly binds to and phosphorylates clk2 on serine 34 and threonine 127, in vitro and in vivo.Our results suggest that akt activation controls cell survival to ionizing radiation by phosphorylating clk2, revealing an important regulatory mechanism required for promoting cell surviva | SIGNOR-167340 |
P06241 | P16885 | 1 | phosphorylation | up-regulates activity | 0.575 | The phosphorylation of purified phospholipase C-gamma 1 (PLC-gamma 1) and PLC-gamma 2 by src-family-protein tyrosine kinases (PTKs) P56lck, p53/56lyn, p59hck, p59fyn, and p60src was studied in vitro. All five PTKs phosphorylated PLC-gamma 1 and PLC-gamma 2, suggesting that both PLC-gamma isozymes can be phosphorylated ... | SIGNOR-249340 |
Q04656 | P08294 | 1 | null | up-regulates activity | 0.696 | Copper transporter ATP7A (copper-transporting/ATPase) is required for full activation of SOD3 (extracellular superoxide dismutase), which is secreted from vascular smooth muscle cells (VSMCs) and anchors to endothelial cell surface to preserve endothelial function by scavenging extracellular superoxide. | SIGNOR-272267 |
P27361 | P17480 | 1 | phosphorylation | down-regulates | 0.579 | Erk1/2 was found to phosphorylate the architectural transcription factor ubf at amino acids 117 and 201 within hmg boxes 1 and 2, preventing their interaction with dna | SIGNOR-112817 |
Q14653 | P52292 | 0 | relocalization | up-regulates activity | 0.2 | The results from Figure 1C suggest that ORF6 inhibits IFN-β production through IRF3 or a component downstream of IRF3. Thus, we examined the effect of ORF6 on IRF3 nuclear translocation. Upon poly(I:C) treatment, IRF3 translocated to the cell nucleus in the absence of ORF6, whereas the expression of ORF6 blocked its nu... | SIGNOR-262514 |
Q13153 | Q9H1Y0 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Here, we identified USP13 as an essential deubiquitinase that stabilizes ATG5 in a process that depends on the PAK1 serine/threonine-protein kinase and which enhances autophagy and promotes IM resistance in GIST cells. |As PAK1-mediated phosphorylation at residue T101 protects ATG5 from ubiquitination-dependent degrada... | SIGNOR-275835 |
Q15418 | P46527 | 1 | phosphorylation | up-regulates activity | 0.393 | As for other PI3K effectors, RSK1 phosphorylates p27 at T198.|RSK1 overexpression increases p27pT198, p27-cyclin D1-Cdk4 complexes, and p27 stability. | SIGNOR-279653 |
O43432 | Q96NX5 | 0 | phosphorylation | up-regulates | 0.2 | Here we report that activity-dependent translational initiation in cultured rat hippocampal neurons is enhanced by camki-mediated phosphorylation of ser1156 in eukaryotic initiation factor eif4gii (4gii). | SIGNOR-197149 |
Q9UNN4 | P68400 | 0 | phosphorylation | up-regulates activity | 0.424 | ALF was able to stabilize the binding of TBP to DNA, but it could not stabilize TBP mutants A184E, N189E, E191R, and R205E nor could it facilitate binding of the TBP-like factor TRF2/TLF to a consensus TATA element. However, phosphorylation of ALF with casein kinase II resulted in the partial restoration of complex for... | SIGNOR-250873 |
Q15678 | P56945 | 1 | dephosphorylation | down-regulates | 0.394 | We show that p130 crk-associated substrate (p130cas) is a direct substrate of ptpn14 and that ptpn14 specifically regulates p130cas phosphorylation at tyrosine residue 128 (y128) in colorectal cancer (crc) cells. We engineered crc cells homozygous for a p130cas y128f knock-in mutant and found that these cells exhibit s... | SIGNOR-197923 |
Q05397 | P16591 | 0 | phosphorylation | up-regulates activity | 0.251 | The Fer mediated phosphorylation of specific tyrosine residues of FAK was abolished by cotransfection of shRNA against Fer (i.e., shFer), but not by control shRNA, indicating that the phosphorylation of Tyr577, 861, or 925 of FAK in suspended cells was indeed caused by Fer. | SIGNOR-279409 |
P63000 | Q68EM7 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.566 | ARHGAP17 is a Rho GTPase-activating protein of Rac1 | SIGNOR-272166 |
Q16620 | P22001 | 1 | phosphorylation | down-regulates | 0.377 | Previously we have shown that acute brain-derived neurotrophic factor (bdnf) activation of neurotrophin receptor tyrosine kinase b (trkb) suppresses the shaker voltage-gated potassium channel (kv1.3) via phosphorylation of multiple tyrosine residues in the n and c terminal aspects of the channel protein. | SIGNOR-183515 |
Q9P275 | P06748 | 1 | deubiquitination | up-regulates quantity by stabilization | 0.39 | USP36 deubiquitylated the nucleolar proteins nucleophosmin/B23 and fibrillarin, and stabilized them by counteracting ubiquitylation-mediated proteasomal degradation. | SIGNOR-272290 |
P62140 | P31749 | 1 | dephosphorylation | down-regulates activity | 0.386 | Here, we identify PP1 as a serine/threonine phosphatase that associates with and dephosphorylates AKT in breast cancer cells|The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells | SIGNOR-252604 |
P16410 | P06241 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.77 | CTLA-4 can associate with the Src kinases Fyn and Lck and that transfection of Fyn or Lck, but not the unrelated kinase ZAP70, can induce tyrosine phosphorylation of CTLA-4 on residues Y201 and Y218.  Phosphorylation of CTLA-4 Y201 in Jurkat cells correlated with cell surface accumulation of CTLA-4. | SIGNOR-251161 |
P60484 | P19784 | 0 | phosphorylation | down-regulates activity | 0.704 | We used mass spectrometric methods to identify Ser(370) and Ser(385) as in vivo phosphorylation sites of PTEN. These sites also are phosphorylated by CK2 in vitro, and phosphorylation inhibits PTEN activity towards its substrate, PIP3. We also identify a novel in vivo phosphorylation site, Thr(366). | SIGNOR-251025 |
Q9NYV6 | P24941 | 0 | phosphorylation | up-regulates | 0.508 | Cdk2/cyclin e-mediated phosphorylation at ser 44 activates tif-ia | SIGNOR-123231 |
Q2M2I8 | Q96CW1 | 1 | phosphorylation | up-regulates | 0.79 | Aak1 is enriched at presynaptic terminals, whereas in nonneuronal cells it colocalizes with clathrin and ap2 in clathrin-coated pits and at the leading edge of migrating cells. Aak1 specifically phosphorylates the mu subunit in vitro, and stage-specific assays for endocytosis show that mu phosphorylation by aak1 result... | SIGNOR-115657 |
O15217 | P0DMV8 | 0 | relocalization | up-regulates activity | 0.2 | Model showing Ser189/Thr193 protein kinase dependent phosphorylation of GST A4‐4 has increased affinity for chaperone Hsp70 which activates mitochondrial competent import signals for GSTA4‐4. |Protein kinase A mediated phosphorylation of serine residues of CYPs increases the affinity of proteins for binding to cytoplas... | SIGNOR-264799 |
Q9NQC7 | Q14164 | 0 | phosphorylation | down-regulates activity | 0.441 | CYLD is phosphorylated by IKK\u03b5 at Ser418.|Together, these observations demonstrate that I\u03baB kinase\u03b5-mediated phosphorylation of CYLD at Ser418 inhibits CYLD deubiquitinase activity. | SIGNOR-278311 |
P13807 | Q96RG2 | 0 | phosphorylation | down-regulates activity | 0.508 | Recombinant human PASK (hPASK) phosphorylates purified muscle glycogen synthase, causing robust inactivation. Furthermore, hPASK interacts directly with glycogen synthase when expressed in cultured cells and this interaction and the phosphorylation of glycogen synthase by human PASK (hPASK) are inhibited by glycogen. | SIGNOR-245866 |
Q8IYT8 | Q9UGI9 | 1 | phosphorylation | down-regulates | 0.2 | Ulk1/2 in turn phosphorylates all three subunits of ampk and thereby negatively regulates its activity. | SIGNOR-173095 |
Q86WV6 | Q9C029 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | RNF90 promoted K48-linked ubiquitination of MITA and its proteasome-dependent degradation.|Finally, in vitro ubiquitination assays suggested that RNF90 promoted the ubiquitination of MITA directly (Fig 5E and 5F). | SIGNOR-278678 |
Q92934 | P11309 | 0 | phosphorylation | down-regulates activity | 0.371 | Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. pim kinases are constitutively active when expressed in HEK-293 cells and are able to phosphorylate the Bcl-2 family member Bad on three residues, Ser112, Ser136 and Ser155 in vitro and in cells. | SIGNOR-250390 |
P06239 | P32119 | 1 | phosphorylation | down-regulates activity | 0.2 | Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling. To determine whether Prxs are phosphorylated, we subjected recombinant human PrxI and II to an in vitro kinase assay with two nonreceptor PTKs, Lck and Abl, in the presence of [γ-32P]ATP. Both PTKs phosphorylat... | SIGNOR-276279 |
P00533 | O14964 | 1 | phosphorylation | up-regulates activity | 0.637 | We have analysed hrs phosphorylation in response to epidermal growth factor (egf) stimulation and show that the evolutionary conserved tyrosines y329 and y334 provide the principal phosphorylation sitesover-expression of wild-type hrs or a double mutant, y329/334f, defective in egf-dependent phosphorylation, substantia... | SIGNOR-100246 |
P46531 | Q92831 | 0 | acetylation | up-regulates | 0.602 | In earlier studies, we demonstrated that maml1 enhanced p300 acetyltransferase activity, which increased the acetylation of notch by p300.Acetylation controls notch stability and function in t-cell leukemia. | SIGNOR-199024 |
P42773 | Q13351 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.266 | Thus, EKLF is a direct regulator of p18INK4c gene expression, and much of EKLF's role in driving erythroid cell differentiation may occur via p18INK4c. | SIGNOR-266046 |
Q96PU5 | Q9NY46 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.283 | The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of ... | SIGNOR-253464 |
P40763 | Q15262 | 0 | dephosphorylation | down-regulates activity | 0.374 | In this study, we investigated whether receptor-type tyrosine protein phosphatase kappa (PTPRK), the only protein tyrosine phosphatase at 6q that contains a STAT3 specifying motif, negatively regulates STAT3 activation in NKTCL.|Phosphatase substrate-trapping mutant assays demonstrated the binding of PTPRK to STAT3, an... | SIGNOR-277060 |
P31994 | P07948 | 0 | phosphorylation | up-regulates activity | 0.43 | Therefore, we conclude that FcgammaRIIb1 phosphorylation upon BCR-FcgammaR coligation is most likely due to BCR-associated Lyn | SIGNOR-249380 |
Q9UEY8 | P17252 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.334 | Results of in vitro experiments with recombinant alpha adducin demonstrated that PKC-phosphorylated adducin was proteolyzed by calpain more quickly than unphosphorylated adducin. | Phosphorylation of adducin by PKC may be a common mechanism for regulating adducin proteolysis by several proteases. | The antibody used i... | SIGNOR-249143 |
P18848 | Q9UGM6 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.246 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269430 |
P01106 | Q96GD4 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.373 | AURKB directly phosphorylates MYC at serine 67, counteracting GSK3\u03b2-directed threonine 58 phosphorylation and subsequent FBXW7- mediated proteasomal degradation. | SIGNOR-279439 |
Q96HS1 | Q8IVP5 | 1 | dephosphorylation | up-regulates activity | 0.627 | Here, we identify that the mitochondrially localized PGAM5 phosphatase interacts with and dephosphorylates FUNDC1 at serine 13 (Ser-13) upon hypoxia or carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) treatment. Dephosphorylation of FUNDC1 catalyzed by PGAM5 enhances its interaction with LC3, which is abrogated... | SIGNOR-273654 |
Q9BW19 | Q13315 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.2 | ATM and ATR kinases phosphorylate KIFC1-S26 during DNA-damage conditions.KIFC1 was stabilized upon phosphorylation and thus promoted centrosome clustering, CIN, and tumor recurrence both in vivo and in vitro. | SIGNOR-277295 |
Q96PU4 | P24864 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.332 | We found that NIRF directly ubiquitinated cyclins D1 and E1, as evidenced by the appearance of the tail (Fig. 4B). In summary, the above findings suggest that NIRF tightly cooperates with the core cell cycle machinery and induces G1 arrest, which is accompanied by ubiquitination of cyclins D1 and E1. | SIGNOR-271886 |
P52630 | P23458 | 0 | phosphorylation | up-regulates activity | 0.768 | STAT2 plays a pivotal role in IFN-a signaling. It is recruited to the activated receptor first and, after phosphorylation by JAK kinases on tyrosine 690, provides a docking site for the SH2 domain of STAT1. | SIGNOR-251344 |
Q05086 | O43166 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.365 | the purified E6AP enhanced the ubiquitination and degradation of E6TP1 in the presence of E6 in vitro. Additionally, the expression of a dominant-negative E6AP mutant (C833A) in cells inhibited the E6-induced degradation of E6TP1. These findings demonstrate that the E6-induced decrease in the levels of E6TP1 protein i... | SIGNOR-272608 |
P49841 | P07384 | 0 | cleavage | up-regulates activity | 0.297 | Thus, it has been shown that calpain cleaves the inhibitory domain of GSK3 generating two fragments of 40 and 30 kDa. This cleavage enhanced activity of the kinase | SIGNOR-251586 |
P51608 | Q9NWB1 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.28 | MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. | SIGNOR-264681 |
O43318 | Q13114 | 0 | ubiquitination | up-regulates activity | 0.457 | Biological investigations demonstrated that TRAF3 activates TAK1 protein kinase activity via a direct binding to TAK1, then the RING finger of TRAF3 ubiquitinates TAK1, leading to TAK1 phosphorylation and activation.|TRAF3 activates TAK1 through ubiquitination. | SIGNOR-278787 |
Q5GLZ8 | Q99835 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Our data showed that Herc4 mediated Smo degradation by proteasome and lysosome, but mainly by proteasome.|Using the cell based ubiquitination assay, we found that both Myc-SmoK13R and Myc-SmoK49R exhibited reduced ubiquitination compared with Myc-Smo by Herc4, but Myc-SmoK49R resulted in a more dramatic reduction in Sm... | SIGNOR-278521 |
P41162 | Q16828 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | ETV3 target genes including etv3, ddx20, and dusp6 provide negative feedback regulation of ETV3 production and activity. Negative feedback along with constitutive instability may serve to tightly regulate ETV3 abundance. Our date suggest that phosphorylation by ERK2 relieves repression by ETV3, allowing activation of c... | SIGNOR-262780 |
Q13554 | Q13224 | 1 | phosphorylation | up-regulates activity | 0.606 | By peptide mapping, automated sequencing, and mass spectrometry, we identified the major site of phosphorylation on the fusion protein as Ser-383, corresponding to Ser-1303 of full-length NR2B. The Km for phosphorylation of this site in the fusion protein was approximately 50 nM, much lower than that of other known sub... | SIGNOR-250688 |
Q96AP0 | Q9HC98 | 0 | phosphorylation | up-regulates activity | 0.2 | NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment|Shelterin component TPP1 plays critical roles in chromosome end protection and telomere length regulation. Specifically, TPP1 contains an OB-fold domain that provides an interface to recruit telomerase.| | SIGNOR-264424 |
Q86YD1 | Q7Z6Z7 | 0 | ubiquitination | down-regulates quantity | 0.2 | Our data suggest that HUWE1 can ubiquitinate PTOV1 in vitro and depletion of HUWE1 in cells increases the stability of PTOV1 S36A protein in the nucleus.|Our data suggest that depletion of HUWE1 elevates PTOV1 protein levels, which, in turn, promote the expression of cJun, a pro-growth translational target of PTOV1 (18... | SIGNOR-278755 |
Q6J4K2 | P17612 | 0 | phosphorylation | up-regulates activity | 0.2 | However, the PDE2-inhibitory effect is eliminated when the mitochondrial S258A NCLX mutant that mimics a non-PKA phosphorylated state of NCLX is expressed. Altogether, our findings indicate that NCLX is regulated by the mitochondrial PDE2A2 form.|We show that caffeine, by inhibiting PDE2, enhances PKA phosphorylation l... | SIGNOR-275727 |
O00429 | Q969V5 | 0 | sumoylation | up-regulates activity | 0.534 | Through a detailed analysis, we find that Drp1 interacts with the SUMO-conjugating enzyme Ubc9 via multiple regions and demonstrate that Drp1 is a direct target of SUMO modification by all three SUMO isoforms. | SIGNOR-274128 |
P67775 | Q13153 | 1 | dephosphorylation | down-regulates activity | 0.357 | Both sites were dephosphorylated with the same kinetics; the anti-Ser(P)198 antibody was subsequently used as it exhibited lower background staining. Direct comparison of PP2Cα with purified PP1 and PP2A lead us to conclude that at the same molar ratio PP2Cα was the most efficient in dephosphorylating PAK1 (Fig. 1D). I... | SIGNOR-248641 |
P17612 | Q15208 | 1 | phosphorylation | down-regulates activity | 0.295 | GSK-3β phosphorylated STK38 on residues S6 and T7 in vitro, depending largely on a PKA-mediated priming phosphorylation of STK38 on residues S10 and S11, respectively. Our results indicate that that GSK-3β inhibits STK38's full activation, and suggest that STK38 activation is required to prevent cell death in response... | SIGNOR-276390 |
Q9BXL7 | P67775 | 0 | dephosphorylation | down-regulates activity | 0.309 | NF-kappaB activation is triggered by PKCtheta-dependent phosphorylation of Carma1 after TCR/CD28 co-stimulation. PKCtheta-phosphorylated Carma1 was suggested to function as a molecular scaffold that recruits preassembled Bcl10-Malt1 complexes to the membrane|we demonstrate that PP2A removes PKCtheta-dependent phosphory... | SIGNOR-248650 |
P54274 | O95271 | 0 | ADP-ribosylation | down-regulates activity | 0.803 | Tankyrase 1 ADP-ribosylates TRF1, inhibiting its binding to telomeric DNA. | SIGNOR-263377 |
P17612 | P13807 | 1 | phosphorylation | down-regulates activity | 0.508 | The results presented in this paper show that the phosphorylation of glycogen synthetase a by cyclic AMP-dependent protein kinase results in the phosphorylation of two distinct serines termed site-l and site-2, which account for 90% of the total phosphorylation | SIGNOR-253009 |
P26358 | Q9BZS1 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.488 | Our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35) | SIGNOR-269053 |
P00533 | P25098 | 1 | phosphorylation | up-regulates activity | 0.2 | Previous studies showed that EGFR activation results in association of GRK2 with the EGFR and subsequent phosphorylation of GRK2 at three tyrosine residues (Tyr 13, -86, and -92), resulting in activation of GRK2.|We propose that GRK2 activation by EGFR leads to GRK2 phosphorylation of Mst2 at these sites, which, in tur... | SIGNOR-279368 |
Q969T9 | P12931 | 0 | phosphorylation | up-regulates activity | 0.297 | Using dominant-negative, constitutively active mutants, RNAi, and pharmacological studies, we demonstrated that phosphorylation of WBP2 at Tyr192 and Tyr231 could be regulated by c-Src and c-Yes kinases.We further showed that abrogating WBP2 phosphorylation impaired >60% of ERα reporter activity, putatively by blocking... | SIGNOR-273567 |
P49585 | Q02086 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Sp3 is an activator, and Sp2 a repressor, of the Ctpct promoter in SL2 cells. | SIGNOR-266230 |
P42229 | P17706 | 0 | dephosphorylation | down-regulates activity | 0.733 | Upon ligand binding, IL-2R , IL-6R or LeptinR , IFN-_R , IFN-_R and PRLR or growth hormone (GH) receptor associated JAKs become activated. These JAKs mediate phosphorylation of specific tyrosine residues and recruit STATs. Activated STATs are released from the receptor and translocate to the nucleus. PTP1B dephosphory... | SIGNOR-133547 |
P35236 | P27361 | 0 | phosphorylation | up-regulates activity | 0.693 | First, Erk phosphorylates HePTP at residues Thr45 and Ser72. Second, HePTP dephosphorylates Erk at PTyr185.| | SIGNOR-249475 |
P28482 | Q09472 | 1 | phosphorylation | up-regulates | 0.466 | Erk2-mediated c-terminal serine phosphorylation of p300 (ser-2279, ser-2315, and ser-2366) is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression. | SIGNOR-156891 |
P04083 | P17252 | 0 | phosphorylation | up-regulates | 0.2 | The authors identified several phosphorylated residues by a combination of peptide mapping and sequence analysis and showed that recombinant pp60c-src phosphorylates annexin a1 near its amino terminus, at tyrosine 21 (tyr21). Also polyoma virus middle t/pp60c-src complex, recombinant pp50v-abl, and the egf receptor/kin... | SIGNOR-202780 |
P01019-PRO_0000032458 | Q9NY33 | 0 | cleavage | down-regulates quantity by destabilization | 0.2 | Human dipeptidyl-peptidase III (hDPP III) is capable of specifically cleaving dipeptides from the N-terminal of small peptides with biological activity such as angiotensin II (Ang II, DRVYIHPF), and participates in blood pressure regulation, pain modulation, and the development of cancers in human biological activities... | SIGNOR-268463 |
P49715 | P63279 | 0 | sumoylation | down-regulates activity | 0.2 | C/EBPalpha interacts directly with the E2 SUMO-conjugating enzyme Ubc9 and can be SUMOylated in vitro using purified recombinant components. Our results indicate that SUMO modification of SC motifs provides a means to rapidly control higher order interactions among transcription factors and suggests that SUMOylation ma... | SIGNOR-256334 |
P12931 | Q9Y446 | 1 | phosphorylation | up-regulates activity | 0.306 | We have discovered that reactive oxygen species (ROS) trigger the c-Src kinase-mediated tyrosine (Tyr)-195 phosphorylation of PKP3. This modification is associated with a change in the subcellular distribution of the protein. Specifically, PKP3 bearing phospho-Tyr-195 is released from the desmosomes, suggesting that ph... | SIGNOR-273807 |
P23582 | Q15714 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.257 | TSC-22 significantly enhanced CNP promoter activity in GH3 cells. | SIGNOR-266226 |
P16591 | P07900 | 0 | phosphorylation | down-regulates activity | 0.3 | Hsp90 and tyrosine616 are required for Fer tyrosine kinase activity.Taken together, our findings underscore the importance of Hsp90 and the residue, tyrosine616, which resides in the Hsp90 recognition loop, in maintaining Fer tyrosine kinase activity. | SIGNOR-277818 |
P24941 | P07948 | 0 | phosphorylation | down-regulates activity | 0.353 | We also show that Lyn phosphorylates Tyr15 of Cdk2 and that incubation of Lyn with Cdk2 results in inhibition of Cdk2 activity. | SIGNOR-279204 |
Q9Y2T1 | Q9H2K2 | 0 | ADP-ribosylation | down-regulates quantity by destabilization | 0.697 | Together, these findings are consistent with the hypothesis that TNKS promotes the ubiquitination and degradation of axin, which may be mediated, at least in part, through the direct PARsylation of axin. | SIGNOR-263380 |
Q15334 | P41743 | 0 | phosphorylation | up-regulates activity | 0.632 | This finding indicates that both mLgl-2 and mLgl-1 are phosphorylated in vivo in an aPKC lambda activity-dependent manner. | SIGNOR-263179 |
P11802 | Q13761 | 1 | phosphorylation | down-regulates | 0.399 | Our findings demonstrate that the cell cycle proteins cyclin d1 and cdk4 induce runx2 and runx3 phosphorylation, ubiquitylation and proteasomal degradation. | SIGNOR-185120 |
P54577 | Q2TAL8 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269412 |
Q14457 | P53355 | 0 | phosphorylation | up-regulates | 0.727 | The activated form of DAPK triggers autophagy in a beclin-1-dependent manner. DAPK phosphorylates beclin 1 on Thr 119 located at a crucial position within its BH3 domain, and thus promotes the dissociation of beclin 1 from Bcl-XL and the induction of autophagy. | SIGNOR-183548 |
P35226 | P42771 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.455 | In HEK293A cells transfected with luciferase reporter constructs, necdin relieves Bmi1-dependent repression of p16 promoter activity, | SIGNOR-253385 |
P27815 | P49137 | 0 | phosphorylation | down-regulates activity | 0.347 | Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. In the present study, we show that PDE4A5 is phosphorylated at Ser147, within the regulatory UCR1 (ultraconserved region 1) domain conserved among PDE4 long isoforms, by ... | SIGNOR-263078 |
P00519 | P0DP91 | 1 | phosphorylation | up-regulates activity | 0.271 | These data raise the possibility that tyrosine phosphorylation of CSB by c-Abl promotes redistribution of CSB in the nucleus and enrichment of CSB in the nucleolus in response to oxidative stress | SIGNOR-279317 |
P17612 | Q14847 | 1 | phosphorylation | down-regulates activity | 0.306 | Lasp-1 binds to non-muscle filamentous (F) actin in vitro in a phosphorylation-dependent manner. Phosphorylation of recombinant lasp-1 with recombinant PKA increased the Kd and decreased the Bmax for lasp-1 binding to F-actin. PKA-dependent phosphorylation sites in rabbit lasp-1 to S99 and S146 | SIGNOR-250074 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.