IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q9H7Z6 | P49327 | 1 | acetylation | down-regulates quantity by destabilization | 0.2 | Overexpression of Myc-KAT8 increased the acetylation level of endogenous FASN by 2.2-fold (Fig. 3C). In contrast, knockdown of KAT8 decreased endogenous FASN acetylation by as much as 55% | SIGNOR-267366 |
P19086 | P28222 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257115 |
P51587 | Q9BXW9 | 2 | binding | up-regulates activity | 0.812 | Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction | SIGNOR-263238 |
Q02548 | P27361 | 0 | phosphorylation | down-regulates activity | 0.247 | In this study, we demonstrated that PAX5 was phosphorylated by ERK1/2 in vitro and in vivo at serines 189 and 283. This phosphorylation attenuated the transcriptional repression of BLIMP1 by PAX5. | SIGNOR-269086 |
Q19QW5 | P52292 | 1 | relocalization | down-regulates activity | 0.2 | Taken together, these data support a direct interaction between KPNA2 and ORF6 in the context of virus infection.|SARS-CoV, but not SARSdeltaORF6, retains KPNA2 at the ER/Golgi membrane. | SIGNOR-260272 |
Q12756 | P0DP23 | 2 | binding | up-regulates activity | 0.275 | To better understand how KIF1A-driven dense core vesicle (DCV) transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium binding protein calmodulin (CaM) and two synaptic scaffolding proteins: liprin-α and TANC2. We showed that calcium, acting via CaM, enhances KIF1A... | SIGNOR-266888 |
Q92731 | P03372 | 2 | binding | up-regulates | 0.527 | It was recently shown that er? And er? Could form a heterodimer complex both in vitro and in vivo | SIGNOR-64427 |
Q12933 | Q8IUC6 | 1 | polyubiquitination | up-regulates | 0.433 | Here, we show that the TRAF family proteins directly bind TICAM-1 and demonstrate that TRAF2 and TRAF6 bind different sites of the N-terminal TICAM-1 and accelerate its polyubiquitination. we speculate that polyubiquitination of TICAM-1 by TRAF2 and TRAF6 is required for TICAM-1 to induce IRF-3 and NF-κB activation. Th... | SIGNOR-271427 |
Q99683 | Q9H2G2 | 0 | phosphorylation | up-regulates | 0.253 | Induction of apoptosis by the ste20-like kinase slk, a germinal center kinase that activates apoptosis signal-regulating kinase and p38 | SIGNOR-142665 |
P03372 | P17612 | 0 | phosphorylation | down-regulates | 0.486 | Phosphorylation of human estrogen receptor alpha by protein kinase a regulates dimerizationeralpha is phosphorylated by protein kinase a (pka) on serine-236 within the dna binding domain. Mutation of serine-236 to glutamic acid prevents dna binding by inhibiting dimerization by eralpha | SIGNOR-63984 |
P09471 | P32238 | 2 | binding | up-regulates activity | 0.252 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257236 |
Q08881 | P06239 | 0 | phosphorylation | up-regulates | 0.554 | Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. The major site of Lck phosphorylation on Itk was mapped to the conserved tyrosine (Tyr511) in the activation loop of the Itk kinase domain. | SIGNOR-251380 |
P49354 | O14807 | 1 | null | up-regulates activity | 0.2 | Major investments have been made to target Ras through indirect routes. Inhibition of farnesyl transferase to block Ras maturation has failed in large clinical trials. | SIGNOR-242553 |
Q12913 | Q86YJ5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MARCH9, a member of the RING-CH family of transmembrane E3 ubiquitin ligases, down-regulates CD4, major histocompatibility complex-I (MHC), and ICAM-1 in lymphoid cells. To identify novel MARCH9 substrates, we used high throughput flow cytometry and quantitative mass spectrometry by stable isotope labeling by amino aci... | SIGNOR-271535 |
P30518 | P63092 | 2 | binding | up-regulates activity | 0.589 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256754 |
Q9NPB9 | O00585 | 2 | binding | up-regulates activity | 0.666 | In the present study, however, we demonstrate for the first time the concentration-dependent recruitment of β-arrestins to the atypical chemokine receptor CCX-CKR upon stimulation with CCL19, CCL21, or CCL25 using three different methodologies in various transfected cell lines. | SIGNOR-268417 |
O43524 | O43638 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Fkhl18 suppressed the transcriptional activity of FoxO3a and FoxO4. | SIGNOR-261610 |
P21453 | P31749 | 0 | phosphorylation | up-regulates activity | 0.704 | Activated akt binds to edg-1 and phosphorylates the third intracellular loop at the t(236) residue. Transactivation of edg-1 by akt is not required for g(i)-dependent signaling but is indispensable for rac activation, cortical actin assembly, and chemotaxis | SIGNOR-252467 |
P0C6X7-PRO_0000037317 | P00403 | 2 | binding | down-regulates activity | 0.2 | This result suggests that the nsp10 protein could affect the activities of NADH and cytochrome oxidase II via a direct interaction while being involved in viral replication. | SIGNOR-260254 |
P17612 | P21817 | 1 | phosphorylation | up-regulates activity | 0.326 | PKA-mediated hyperphosphorylation of a conserved serine, Ser-2843 in skeletal RyR and Ser-2809 in cardiac RyR, results in an aberrant SR function during heart failure. hyperphosphorylated RyRs are leaky and therefore lead to a reduced SR Ca2+ load and impaired contractile function in heart failure | SIGNOR-250078 |
P32243 | P14652 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.259 | Transactivation of the mouse OTX2 Luc constructs by the human HOXB1, HOXB2, and HOXB3 proteins. | Likewise, the construct pOTX2LucΔ−710 showed an 8-, 12-, and 6-fold increase in transcriptional activity if co-transfected with pSG-HOXB1, -HOXB2, and -HOXB3, respectively | SIGNOR-261634 |
P12931 | O75553 | 1 | phosphorylation | up-regulates activity | 0.42 | Dab1 is rapidly phosphorylated when neurons isolated from embryonic brains are stimulated with Reelin, and several tyrosines have been implicated in this response. Mice with phenylalanine substitutions of all five tyrosines (Tyr(185), Tyr(198), Tyr(200), Tyr(220), and Tyr(232)) exhibit a reeler phenotype, implying that... | SIGNOR-247080 |
Q9HAU5 | Q92900 | 2 | binding | up-regulates activity | 0.979 | UPF2 and UPF3b increase UPF1 ATPase activity | SIGNOR-265246 |
P19784 | Q9UD71 | 1 | phosphorylation | up-regulates activity | 0.375 | Study of [Plphosphate release during manual Edman degradation confirmed that the phosphorylated residues in rat DARPP-32 were Ser45 and Ser102. | Phosphorylation by casein kinase II did not affect the potency of DARPP-32 as an inhibitor of protein phosphatase-1, which depended only on phosphorylation of Thr34 by cAMP-... | SIGNOR-251018 |
P63092 | O00254 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256761 |
P33151 | Q9UQB3 | 2 | binding | up-regulates quantity by stabilization | 0.316 | To clarify the role of p120 in mammalian cells, we have knocked down p120 with siRNA in cells expressing epithelial (E-), placental (P-), neuronal (N-), and vascular endothelial (VE-) cadherins. We report that each of these cadherins, as well as α- and β-catenins, were rapidly degraded in the absence of p120, resulting... | SIGNOR-252132 |
P42229 | P24394 | 0 | null | up-regulates | 0.556 | Several cytokine receptors share subchains and targets. For example, the common gamma chain (CGC) is shared by IL2, IL4, IL7, IL9 and IL15 receptors that lead to the activation of STAT5 | SIGNOR-254298 |
O15379 | Q8NHE4 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Consistent with previous data, HDAC3 only bound to the ATP6V0E2 promoter in the presence of ALDH2.|Taken together, our data demonstrate that in the macrophages of LDLR-KO or ALDH2 rs671 mutant, AMPK phosphorylates ALDH2 at T356, which enables its nuclear translocation. Once in the nucleus, ALDH2 binds to HDAC3 and supp... | SIGNOR-271868 |
Q12802 | P17612 | 0 | phosphorylation | up-regulates | 0.332 | Using a combination of biochemical, enzymatic, and immunofluorescence techniques, we show that the anchoring protein contributes to pkd activation in two ways: it recruits an upstream kinase pkceta and coordinates pka phosphorylation events that release activated protein kinase d. Thus, akap-lbc synchronizes pka and pk... | SIGNOR-129345 |
P35367 | P63096 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257050 |
Q05086 | P51665 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.271 | Our experiments collectively suggest that UBE3A stimulates Wnt pathway activation by interacting with, ubiquitinating, and reducing the levels of multiple (PSMB1, PSMC2, PSMD2, and PSMD7) proteasome subunits. | SIGNOR-265134 |
P08514 | Q99828 | 2 | binding | up-regulates activity | 0.472 | The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading | SIGNOR-269061 |
O15550 | P31268 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.275 | Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. | SIGNOR-260024 |
O14965 | O15350 | 1 | phosphorylation | down-regulates activity | 0.449 | Aurora-A inhibits p73 and p53 transactivation functions through a common molecular mechanism.|We report that Aurora-A phosphorylation of p73 at serine235 abrogates its transactivation function and causes cytoplasmic sequestration in a complex with the chaperon protein mortalin. | SIGNOR-278263 |
Q99665 | P29459 | 2 | binding | up-regulates | 0.578 | Il-12r beta 2 plays an essential role in mediating the biological functions of il-12 in mice. | SIGNOR-84361 |
P08887 | P40189 | 2 | binding | up-regulates | 0.751 | Part of the receptor for interleukin 6. Binds to il6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with il6st. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | SIGNOR-105504 |
Q15759 | P30281 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation. | SIGNOR-280023 |
P19784 | P55087 | 1 | phosphorylation | down-regulates activity | 0.338 | We found that the stress-induced kinase casein kinase (CK)II phosphorylates the Ser276 immediately preceding the tyrosine motif, increasing AQP4-mu 3A interaction and enhancing AQP4-lysosomal targeting and degradation. | To determine whether Ser276 is an actual CKII substrate, we used GST–AQP4‐Cter proteins in which on... | SIGNOR-250976 |
Q5VWK5 | Q9NPF7 | 2 | binding | up-regulates | 0.861 | We identify a novel member of the hemopoietin receptor family as a subunit of the receptor for il-23, il-23r. | SIGNOR-87805 |
Q9Y5G5 | Q9Y5I2 | 2 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265702 |
P27037 | Q04771 | 2 | binding | up-regulates | 0.664 | The major bmp7 type i receptor observed was alk2, | SIGNOR-60234 |
P06493 | Q12834 | 1 | phosphorylation | down-regulates activity | 0.935 | Cdk1 phosphorylates Cdc20 to negatively regulate its ability to bind and activate the APC/C. | SIGNOR-279321 |
P19086 | Q9UKP6 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257319 |
O75197 | P56705 | 2 | binding | up-regulates | 0.649 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-131832 |
Q9HDB5 | Q9NZ94 | 2 | binding | up-regulates activity | 0.825 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264167 |
P17252 | Q07954 | 1 | phosphorylation | up-regulates | 0.2 | Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase calpha regulates endocytosis and association with adaptor moleculesthese results indicate that elimination of serine and threonine phosphorylation sites in the lrp cytoplasmic domain reduces the extent of tyr6... | SIGNOR-127215 |
P37231 | P00519 | 0 | phosphorylation | up-regulates quantity | 0.341 | We show that the tyrosine kinase Abelson murine leukemia viral oncogene (cAbl) is an adipogenic key regulator. c-Abl promotes adipogenesis by phosphorylation and subsequent stabilization of PPARγ. | SIGNOR-262297 |
Q14247 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.2 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254696 |
Q99835 | P04899 | 2 | binding | up-regulates activity | 0.429 | it was proposed that Smo might signal through activation of Gi proteins to reduce PKA activity. | SIGNOR-199162 |
O14773 | O76064 | 0 | ubiquitination | up-regulates activity | 0.302 | Our data demonstrate that RNF8 directly ubiquitylates and stabilizes TPP1 at telomeres.|Taken together, these results suggest that RNF8 dependent K63 linked, but not K48 linked ubiquitin chain formation on TPP1 is required to promote TPP1 stability and function at telomeres. | SIGNOR-278574 |
O14744 | Q15831 | 0 | phosphorylation | up-regulates activity | 0.2 | We found that PRMT5 is a bona fade substrate for LKB1. We identified T132, 139 and 144 residues, located in the TIM-Barrel domain of PRMT5, as target sites for LKB1 phosphorylation. The point mutation of PRMT5 T139/144 to A139/144 drastically decreased its methyltransferase activity, due probably to the loss of its int... | SIGNOR-277412 |
P36956 | Q5VTR2 | 0 | ubiquitination | down-regulates activity | 0.425 | Here, we reveal that RNF20-induced SREBP1c ubiquitination down-regulates hepatic lipogenic activity upon PKA activation.|Overexpression of RNF20 represses SREBP1c activity, leading to a decrease in the expression of lipogenic genes. | SIGNOR-278643 |
P19174 | P16234 | 0 | phosphorylation | up-regulates | 0.65 | Tyrosine phosphorylation has been shown to increase the enzymatic activity of plc-? / we show that the human pdgf ?- And ?-Receptors differ quantitatively in their abilities to associate with and phosphorylate plc-? And to stimulate inositol phosphate production. | SIGNOR-28176 |
O43353 | Q15306 | 2 | binding | down-regulates activity | 0.478 | These studies demonstrate that inhibition of RICK (RIPK2) polyubiquitination by IRF4 involves polyubiquitination of the kinase domain of RICK and this inhibition is facilitated by binding of IRF4 to the kinase and/or intermediate domains of RICK. | SIGNOR-280454 |
O95837 | P34969 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257430 |
Q13153 | P35222 | 1 | phosphorylation | up-regulates | 0.557 | Pak1 directly phosphorylates _-catenin proteins at ser675 site and this leads to more stable and transcriptional active _-catenin | SIGNOR-175944 |
Q13490 | Q9Y385 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.37 | We also found that ubiquitin-ligase (E3), c-IAP1 preferentially interacts with phosphorylated Ube2j1. Moreover, we noticed that phosphorylated Ube2j1 is rapidly degraded by the proteasome during ER stress cell recovery. Taken together, these data suggest that Ube2j1 and its phosphorylation is important for transient ER... | SIGNOR-263092 |
Q9NXA8 | O94925 | 2 | binding | up-regulates activity | 0.449 | Immunoprecipitation assays of interaction between GLS and SIRT5 in HepG2 cells infected with lentivirus containing empty or BAG3 construct. Ectopic BAG3 expression decreases the interaction between GLS and SIRT5. It has been reported that SIRT5 is responsible for desuccinylation of GLS35, immunoprecipitation (IP) was ... | SIGNOR-261207 |
Q05397 | O43707 | 1 | phosphorylation | down-regulates | 0.558 | Phosphorylation at y12 by fak reduces _-actinin1's affinity for actin [25] and [27]. _-actinin4 is phosphorylated at y4, y31, and y265. Phosphorylation at y4 or y31 decreases its binding to actin [28] while phosphorylation of y265 increases its affinity for actin | SIGNOR-192195 |
P29597 | Q14765 | 1 | phosphorylation | up-regulates activity | 0.656 | IL-12 activates the Janus family tyrosine kinases JAK2 and Tyk2, which in turn phosphorylate STAT4 on tyrosine 693. | SIGNOR-279303 |
O15530 | P00558 | 2 | phosphorylation | up-regulates activity | 0.2 | PDPK1 Phosphorylates PGK1 T243. Macrophages increase PGK1 pT243 to reduce the 3-PG affinity of PGK1, which alters the equilibrium of the PGK1-catalyzed reaction toward glycolysis, promoting tumor cell proliferation. | SIGNOR-277402 |
P60568 | Q9UL17 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.473 | T-bet Transactivates the IFNγ Gene and Represses the IL-2 Gene in EL4 Cells | SIGNOR-266233 |
P56524 | Q5H9F3 | 2 | binding | up-regulates activity | 0.427 | BCoR-L1 interacts with Class II HDACs, HDAC4, HDAC5, and HDAC7, suggesting that they are involved in its function as transcriptional corepressor. | SIGNOR-259112 |
P49841 | O95863 | 1 | phosphorylation | down-regulates | 0.557 | Snail is a well-known zn-finger transcription factor that promotes emt by repressing e-cadherin expression. It is known that snail is phosphorylated by gsk3beta and degraded by beta-trcp-mediated ubiquitination. A variant of snail (snail-6sa), which abolishes these phosphorylations, is much more stable and resides excl... | SIGNOR-129402 |
P00519 | Q8WYQ5 | 1 | phosphorylation | up-regulates activity | 0.2 | The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage. When coexpressed in HEK293T cells, ABL phosphorylated DGCR8 at Tyr(267). | SIGNOR-262604 |
P31751 | Q99683 | 1 | phosphorylation | down-regulates activity | 0.646 | Akt2 interacts with and phosphorylates ask1 at ser-83 resulting in inhibition of its kinase activity | SIGNOR-100588 |
P42338 | P49841 | 1 | phosphorylation | down-regulates activity | 0.48 | In our cultures, both p110alpha and p110beta phosphorylated GSK-3beta at Ser9 confirming previous data.|Whereas p110alpha reduced the protein levels of the CDK2-inhibitor p27 Kip1, p110beta phosphorylated and inactivated GSK-3beta. | SIGNOR-279089 |
Q9H6T0 | Q6ZNA4 | 0 | ubiquitination | up-regulates activity | 0.388 | These findings suggest that Arkadia ubiquitinates ESRP2 and potentiates the splicing function of ESRP2 ( ). | SIGNOR-278613 |
P17948 | P15692 | 2 | binding | up-regulates | 0.843 | Vegf exerts its action by binding to vegfr-1 and vegfr-2. | SIGNOR-121132 |
Q92585 | P68431 | 1 | acetylation | down-regulates activity | 0.2 | The n-terminal domain of maml1 directly interacts with both p300 and histones, and the p300-maml1 complex specifically acetylates histone h3 and h4 tails in chromatin. | SIGNOR-153038 |
Q16539 | P07949 | 0 | phosphorylation | up-regulates | 0.332 | Dually phosphorylated on thr-180 and tyr-182 by the map2ks map2k3/mkk3, map2k4/mkk4 and map2k6/mkk6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. | SIGNOR-40493 |
Q9UPN9 | Q15796 | 2 | binding | up-regulates activity | 0.638 | The ubiquitious nuclear protein transcriptional intermediary factor 1gamma (tif1gamma) selectively binds receptor-phosphorylated smad2/3 in competition with smad4. Rapid and robust binding of tif1gamma to smad2/3 occurs in hematopoietic, mesenchymal, and epithelial cell types in response to tgfbeta. Tif1gamma mediates ... | SIGNOR-236064 |
P35222 | Q05513 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.599 | Yap and β-catenin are direct substrates of PKCζ. Similar MS/MS analysis to map the sites phosphorylated in β-catenin by PKCζ identified S45 and several sites of low abundance that included S552 and S675 (Figure S3C). | SIGNOR-276880 |
P69905 | P30519 | 0 | null | down-regulates activity | 0.254 | Heme oxygenase (HO), by catabolizing heme to bile pigments, down-regulates cellular hemoprotein, hemoglobin, and heme | SIGNOR-251814 |
Q12933 | Q99558 | 2 | binding | down-regulates quantity by destabilization | 0.586 | We report here that one important mechanism of nik regulation is through its dynamic interaction with the tumor necrosis factor receptor-associated factor 3 (traf3). Traf3 physically associates with nik via a specific sequence motif located in the n-terminal region of nik; this molecular interaction appears to target n... | SIGNOR-124233 |
P61289 | Q9NRC8 | 2 | binding | down-regulates quantity by destabilization | 0.2 | Here, the authors show that energy stress induces an AMPK-dependent phosphorylation of Sirt7, which promotes its ubiquitin-independent degradation by REGγ, resulting in the down-regulation of rRNA transcription and cell survival.|These results strongly suggest that the phosphorylation status of SirT7 at T153 plays a cr... | SIGNOR-275866 |
Q9NPG1 | P16520 | 2 | binding | up-regulates | 0.385 | In the non-canonical wnt pathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-termi... | SIGNOR-152603 |
O75676 | Q16539 | 0 | phosphorylation | up-regulates | 0.604 | Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were requ... | SIGNOR-77212 |
Q15436 | Q9NR31 | 2 | binding | up-regulates quantity | 0.823 | Biogenesis of COPII vesicles is initiated by the activation of the small guanosine triphosphate (GTP)-binding protein secretion-associated Ras-related protein 1 (Sar1) at specialized subdomains of the ER, called ER exit sites (ERES) or transitional ER (tER). Membrane-bound Sar1 then recruits the inner COPII coat subcom... | SIGNOR-265299 |
Q14457 | O96017 | 0 | phosphorylation | up-regulates activity | 0.299 | We report that CHK2 binds to and phosphorylates Beclin 1 at Ser90/Ser93, thereby impairing Beclin 1-Bcl-2 autophagy-regulatory complex formation in a ROS-dependent fashion.|CHK2 binds to and phosphorylates Beclin 1 at Ser90/Ser93, promoting autophagy via Beclin 1 release from Bcl‐2 sequestration | SIGNOR-264557 |
P63000 | P45984 | 2 | binding | up-regulates | 0.523 | We show that rac1 activates jnk2 that in turn phosphorylates beta-catenin on critical residues and controls its nuclear translocation. | SIGNOR-178265 |
Q99558 | Q99558 | 2 | phosphorylation | up-regulates activity | 0.2 | As nik levels increase, nik presumably becomes activated by autophosphorylation (p). | SIGNOR-167063 |
P19022 | O00192 | 2 | binding | up-regulates quantity by stabilization | 0.466 | To clarify the role of p120 in mammalian cells, we have knocked down p120 with siRNA in cells expressing epithelial (E-), placental (P-), neuronal (N-), and vascular endothelial (VE-) cadherins. We report that each of these cadherins, as well as α- and β-catenins, were rapidly degraded in the absence of p120, resulting... | SIGNOR-252128 |
P61020 | Q99698 | 2 | binding | down-regulates activity | 0.2 | Mauve interacts with Rab5, Msps, and gamma-tubulin|Mauve/LYST opposes Rab5, which promotes vesicle fusion affecting PCM recruitment | SIGNOR-266002 |
P49841 | P19544 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.284 | Glycogen synthase kinase 3β promoted phosphorylation of cugWT1 at S64, resulting in ubiquitination and degradation of the cugWT1 associated with the F-box-/- WD repeat-containing protein 8. | SIGNOR-277540 |
Q05513 | O43315 | 1 | phosphorylation | up-regulates | 0.2 | Wt-pkc_-mediated phosphorylation of wt aqp9 in vitro. In the experiments, substitution of ser11 to ala markedly inhibited phosphorylation. the s11a mutation in fibroblasts caused a smoother cell periphery with fewer aqp9-induced filopodia | SIGNOR-176278 |
O43524 | O43524 | 2 | transcriptional regulation | up-regulates quantity | 0.2 | We show that FOXO3 binds and activates its own promoter via a positive autoregulatory feedback loop | SIGNOR-255757 |
Q5S007 | P10415 | 1 | phosphorylation | up-regulates activity | 0.329 | Thus, we propose that Thr56 phosphorylation of Bcl-2 by LRRK2 G2019S might be a crucial step of mitochondrial disorder, which initiates the subsequent cellular damage in the context of PD relevant to G2019S.|We found that LRRK2 G2019S induced loss of the MMP was recovered in both GFP-Bcl-2 and GFP-M-Bcl-2 stable cells ... | SIGNOR-279531 |
P78536 | P01135 | 1 | cleavage | up-regulates activity | 0.489 | ADAM17 is involved in the release and activation of several growth factors and cytokine receptor ligands. Among the growth factors activated by ADAM17 are TGF-alpha, amphiregulin, epiregulin and HB-EGF | SIGNOR-259841 |
P42345 | P03372 | 1 | phosphorylation | up-regulates activity | 0.498 | Thus our results indicate that the interaction between ER\u03b1 and raptor is necessary to recruit raptor to the nucleus, where mTOR phosphorylates and activates ER\u03b1. | SIGNOR-278295 |
Q9P2J5 | Q5S007 | 0 | phosphorylation | down-regulates activity | 0.2 | In this study, we elucidated that leucyl-tRNA synthetase (LRS) was an LRRK2 kinase substrate and identified T293 as an LRRK2 phosphorylation site. LRRK2-meidated LRS phosphorylation or G2019S can lead to impairment of LRS editing, increased ER stress, and accumulation of autophagy markers. | SIGNOR-277417 |
Q712K3 | P68400 | 0 | phosphorylation | up-regulates activity | 0.338 | Ck2-dependent phosphorylation of the e2 ubiquitin conjugating enzyme ubc3b induces its interaction with beta-trcp and enhances beta-catenin degradation | SIGNOR-88050 |
P49841 | P23246 | 1 | phosphorylation | down-regulates | 0.345 | Psf is directly phosphorylated by gsk3, thus promoting interaction of psf with trap150, which prevents psf from binding cd45 pre-mrna. / threonine phosphorylation of psf by gsk3 primarily occurs on residue t687 | SIGNOR-168392 |
P30411 | P08754 | 2 | binding | up-regulates activity | 0.401 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256838 |
P13639 | Q9H2P9 | 0 | methylation | down-regulates activity | 0.747 | Analysis of EF2 in the mutant cells revealed a novel form of diphthamide with an additional methyl group that prevented ADP-ribosylation and inactivation of EF2. The abnormal methylation appeared to be catalyzed by DPH5. | SIGNOR-261146 |
P01112 | Q92565 | 0 | guanine nucleotide exchange factor | up-regulates | 0.508 | Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. | SIGNOR-183732 |
O14965 | Q93073 | 1 | phosphorylation | up-regulates quantity | 0.2 | To explore the underlying mechanisms, we found that SLAN, a potential tumor suppressor, served as a substrate of Aurora-A and knockdown of SLAN induced immature cytokinesis. Aurora-A phosphorylates SLAN at T573 under the help of the scaffold protein 14-3-3η. Intriguingly, SLAN T573D or T573E inactivated and T573A activ... | SIGNOR-273547 |
Q92569 | Q9H7P9 | 2 | binding | up-regulates activity | 0.249 | Through deletion and base substitution mutagenesis we have identified Tyr489 of PLEKHG2 as the site phosphorylated by cSrc.The interaction between PLEKHG2 and the full-length of PIK3R3, but not ABL1, occurs in a tyrosine-phosphorylation-dependent manner. | SIGNOR-273809 |
P37231 | Q8IXJ9 | 2 | binding | down-regulates activity | 0.2 | Our genome-wide analysis confirmed the physiological roles of ASXL1 and ASXL2 in adipogenesis at the molecular level, supporting the hypothesis that ASXL1 is an authentic corepressor of PPARγ, whereas ASXL2 is a PPARγ coactivator, and that together ASXL1 and ASXL2 fine-tune adipogenesis via differential regulation of P... | SIGNOR-260064 |
P24941 | Q12974 | 0 | dephosphorylation | up-regulates | 0.2 | Cells overexpressing prl-2 exhibited enhanced cyclin-dependent kinase 2 (cdk2) activity | SIGNOR-119478 |
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