IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q8NEZ5 | O75164 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.339 | SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation | SIGNOR-273442 |
P36888 | Q13322 | 2 | binding | up-regulates activity | 0.364 | These results suggest that Grb10 binds to both normal and oncogenic FLT3 and induces PI3K–Akt and STAT5 signaling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells. | SIGNOR-255947 |
P11362 | Q9Y2J4 | 1 | phosphorylation | up-regulates activity | 0.2 | These data support an idea that Amotl2 Tyr-103 can be phosphorylated by FGF receptor tyrosine kinase activity. We then determined whether Amotl2 Tyr-103 is required for its interaction with c-Src. |Amotl2 promotes MAPK/ERK activation via c-Src, which is dependent on phosphorylation of tyrosine residue at position 103 b... | SIGNOR-271869 |
O00257 | Q9H2X6 | 0 | phosphorylation | up-regulates activity | 0.423 | In addition, HIPK2 phosphorylates Pc2 at several sites, including threonine 495. | SIGNOR-278484 |
Q9Y458 | P35548 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.309 | the main function of TBX22 as shown in misexpression experiments is to decrease proliferation. We subsequently uncovered three targets of TBX22, DLX5, MSX2, and TBX22 itself. All are downregulated in the presence of viral-derived hTBX22. | SIGNOR-265567 |
O43248 | P04271 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.252 | HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells. | SIGNOR-261647 |
Q8N0W4 | P58400 | 2 | binding | up-regulates activity | 0.77 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264150 |
Q9BZL6 | P24723 | 0 | phosphorylation | up-regulates | 0.2 | Thus, pkd2 is likely to be a novel downstream target of specific pkcs upon the stimulation of ags-b cells with gastrin. Our data suggest a two-step mechanism of activation of pkd2 via endogenously produced diacylglycerol and the activation of pkcs. | SIGNOR-89431 |
Q96P20 | Q9BZY9 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.489 | Taken together, these data indicated that TRIM31 directly induced the K48-linked ubiquitination of NLRP3 through its E3 ligase activity.|Taken together, these results indicated that TRIM31 could promote proteasomal degradation of NLRP3. | SIGNOR-278603 |
P11021 | O95260 | 0 | post transcriptional regulation | down-regulates quantity by destabilization | 0.295 | We showed that the molecular chaperone BiP (also known as GRP78) was short-lived under basal conditions and ER stress. The turnover of BiP was in part driven by its amino-terminal arginylation (Nt-arginylation) by the arginyltransferase ATE1, which generated an autophagic N-degron of the N-end rule pathway. | SIGNOR-261345 |
P11274 | P18031 | 0 | dephosphorylation | down-regulates | 0.33 | These results illustrate selectivity in the effects of ptps in a cellular context and suggest that ptp1b may function as a specific, negative regulator of p210 bcr-abl signalling in vivo. | SIGNOR-56818 |
Q05655 | P30411 | 1 | phosphorylation | down-regulates activity | 0.301 | In addition, we found a protein kinase C-dependent phosphorylation of Ser(346) that was mutually exclusive with the basal phosphorylation at Ser(348) and therefore may be implicated in differential regulation of B2 receptor activation. Functional analysis of receptor mutants revealed that a low phosphorylation stoichio... | SIGNOR-249108 |
P49327 | P04626 | 0 | phosphorylation | up-regulates activity | 0.442 | Conversely, HER2 directly phosphorylates and activates FASN, while it also promotes FASN gene expression ( xref ; xref ).|Conversely, HER2 directly phosphorylates and activates FASN, while it also promotes FASN gene expression. | SIGNOR-278399 |
P01019-PRO_0000420660 | P04201 | 2 | binding | up-regulates activity | 0.2 | Recent advances have improved our understanding of the renin-angiotensin system (RAS). These have included the recognition that angiotensin (Ang)-(1-7) is a biologically active product of the RAS cascade. The identification of the ACE homologue ACE2, which forms Ang-(1-7) from Ang II, and the GPCR Mas as an Ang-(1-7) r... | SIGNOR-260229 |
O15111 | Q00653 | 1 | phosphorylation | up-regulates activity | 0.791 | Ikkalfa phosphorylates p100, leading to its proteasomal processing to p52. | SIGNOR-124230 |
Q15759 | O60381 | 1 | phosphorylation | up-regulates | 0.428 | A mutation of the p38 map kinase phosphorylation site at aa 401 [(s-a)401hbp1] also triggered hbp1 protein instability. While protein stability was compromised by mutation, the specific activities of (s-a)401hbp1 and of wild-type hbp1 appeared comparable for transcriptional repression. | SIGNOR-119134 |
Q99708 | P24941 | 0 | phosphorylation | up-regulates | 0.617 | Collectively, these findings thereby provided strong support for ctip thr-847 indeed being a cdk target. it is established that both cdk-dependent and checkpoint-dependent phosphorylations are required for activation of sae2/ctip in vivo | SIGNOR-183840 |
P17612 | O95835 | 1 | phosphorylation | up-regulates | 0.2 | Here, we show that cyclic amp (camp)-dependent protein kinase (pka) phosphorylates lats and thereby enhances its activity sufficiently to phosphorylate yap on ser381. | SIGNOR-236991 |
P10070 | Q8N752 | 0 | phosphorylation | up-regulates | 0.333 | Gli2 is phosphorylated by gsk3 and ck1 for the fbxw11 (betatrcp2)-mediated degradation ci is phosphorylated by pka at multiple sites priming phosphorylation by both gsk3 and cki, leading to partial proteolysis. The pka, gsk3, and cki sites are conserved in gli2 and gli3, vertebrate homologs of ci that are similarly pr... | SIGNOR-179972 |
Q00987 | P46531 | 1 | ubiquitination | up-regulates | 0.476 | Although the interaction between notch1 and mdm2 results in ubiquitination of notch1, this does not result in degradation of notch1, but instead leads to activation of the intracellular domain of notch1. | SIGNOR-200197 |
P08912 | P30679 | 2 | binding | up-regulates activity | 0.385 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257351 |
Q86WV6 | O43318 | 0 | phosphorylation | up-regulates activity | 0.2 | Activated TAK1 directly mediates STING phosphorylation on serine 355, which facilitates its interaction with STING ER exit protein (STEEP) and thereby promotes its oligomerization and translocation to the ERGIC for subsequent activation | SIGNOR-277887 |
P43694 | Q92833 | 2 | binding | down-regulates activity | 0.456 | JMJ physically associates with Nkx2.5 and GATA4 in vitro and in vivo as determined by glutathione S-transferase pull-down and immunoprecipitation assays. we show that JMJ represses ANF gene expression by inhibiting transcriptional activities of Nkx2.5 and GATA4. | SIGNOR-224697 |
Q9BXC1 | Q14344 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257029 |
P01106 | Q13309 | 0 | ubiquitination | down-regulates quantity | 0.736 | The F-box protein Skp2 mediates c-Myc ubiquitylation by binding to the MB2 domain | SIGNOR-243548 |
Q9Y3S1 | Q9H4A3 | 1 | phosphorylation | up-regulates activity | 0.546 | WNK1, which is activated in response to osmotic stress by phosphorylation of its T-loop residue (Ser382). | We found that wild-type WNK2 (Figure 8A) or WNK3 (Figure 8B) phosphorylated kinase-inactive WNK1 (1–667, D368A) at Ser382 in vitro. | SIGNOR-260790 |
Q16236 | Q9UPY5 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.424 | NFE2L2 is stabilized and translocates to the nucleus, where it dimerizes with sMAF proteins. This complex binds to AREs to mediate the transcription of genes involved in iron metabolism, GSH metabolism, and ROS detoxification. NFE2L2 directly binds to the promoter region of SLC7A11, leading to increased expression of t... | SIGNOR-279867 |
P54198 | P24941 | 0 | phosphorylation | up-regulates activity | 0.326 | Hira bound to and was phosphorylated by cyclin a- and e-cdk2 in vitrohira became phosphorylated on threonine 555 in s phase when cyclin-cdk2 kinases are active.ectopic expression of hira in cells caused arrest in s phase and this is consistent with the notion that it is a cyclin-cdk2 substrate that has a role in contro... | SIGNOR-105548 |
Q96EB6 | P17861-2 | 1 | deacetylation | down-regulates activity | 0.379 | P300 increases the acetylation and protein stability of XBP1s, and enhances its transcriptional activity, whereas SIRT1 deacetylates XBP1s and inhibits its transcriptional activity.. The mRNA encoding the active spliced form of XBP1 (XBP1s) is generated from the unspliced form by IRE1 (inositol-requiring enzyme 1) duri... | SIGNOR-260430 |
Q9BZI1 | P28482 | 0 | phosphorylation | up-regulates activity | 0.2 | We tested the transcriptional properties of Irx2 by dividing it into amino- and carboxy terminal parts and found that Mek1-mediated phosphorylation activates and derepresses the amino and carboxyl parts, respectively. When Ser46 and Ser65 were mutated to alanine (S46A and S65A), phosphorylation was reduced, whereas sub... | SIGNOR-263052 |
P35558 | Q86UZ6 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | We identified LIF/ZBTB46 signalling as a key promoter of metabolic reprogramming and NE differentiation of PCa cells through interactions with PCK1. We showed that ZBTB46 directly upregulates the expression of PCK1 and NE marker gene through activation of LIF signalling. | SIGNOR-277987 |
P28482 | O15067 | 1 | phosphorylation | up-regulates | 0.2 | T619 in PFAS is required to mediate ERK2-dependent purine synthesis stimulation. We demonstrate that ERK2, but not ERK1, phosphorylates the purine synthesis enzyme PFAS (phosphoribosylformylglycinamidine synthase) at T619 in cells to stimulate de novo purine synthesis. The expression of nonphosphorylatable PFAS (T619A... | SIGNOR-267306 |
P05231 | P11831 | 0 | null | up-regulates | 0.281 | Srf within myofibers modulates Il6 and Cox2/Il4 expressions and, therefore, exerts a paracrine control of satellite cell proliferation and fusion, respectively, which in turn support skeletal muscle hypertrophy. | SIGNOR-255966 |
P78527 | P14859 | 1 | phosphorylation | down-regulates | 0.33 | Through a similar strategy, t226 and s232 were characterized as the dna-pk phosphorylation sites | SIGNOR-53258 |
P16949 | P06493 | 0 | phosphorylation | up-regulates activity | 0.641 | null | SIGNOR-279803 |
Q13469 | P45983 | 0 | phosphorylation | down-regulates | 0.752 | Jnks directly phosphorylate nuclear factor of activated t-cell (nfat) transcription factors, thus antagonizing the effects of calcium-regulated signaling through the protein phosphatase calcineurin jnk directly regulated nuclear factor of activated t-cell (nfat) activation in culture and in transgenic mice containing ... | SIGNOR-118217 |
O43791 | O15164 | 2 | binding | down-regulates quantity by destabilization | 0.337 | Here, we analyzed changes in the ubiquitin landscape induced by prostate cancer-associated mutations of SPOP, an E3 ubiquitin ligase substrate-binding protein. SPOP mutants impaired ubiquitylation of a subset of proteins in a dominant-negative fashion. Of these, DEK and TRIM24 emerged as effector substrates consistentl... | SIGNOR-272825 |
O75056 | P46531 | 2 | binding | up-regulates activity | 0.379 | Furthermore, we show that Syndecan-3 interacts with Notch and is required for Notch processing by ADAM17/tumor necrosis factor-converting enzyme (TACE) and signal transduction. Together, our data support the conclusion that Syndecan-3 and Notch cooperate in regulating homeostasis of the satellite cell population and ... | SIGNOR-244072 |
P35462 | P19086 | 2 | binding | up-regulates activity | 0.315 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257097 |
Q9BZL6 | Q9GZY8 | 1 | phosphorylation | up-regulates activity | 0.2 | The mitochondrial fission factor (MFF), the main mitochondrial receptor for the Dynamin-related protein 1 (DRP1), is directly phosphorylated by Protein Kinase D (PKD) specifically during mitosis. PKD-dependent MFF phosphorylation is required and sufficient for mitochondrial fission in mitotic but not in interphasic cel... | SIGNOR-275947 |
Q9UHD2 | P35813 | 0 | dephosphorylation | down-regulates activity | 0.41 | Furthermore, PPM1A, but not PPM1B, serves as an efficient phosphatase to dephosphorylate Ser 172 residue of both TBK1 and IKKepsilon kinases, which is critical for their kinase activities.|In a similar in vitro phosphatase assay, incubation of PPM1A also eliminated TBK1 and IKKepsilon phosphorylation at Ser 172 residue... | SIGNOR-276966 |
P24941 | Q96T88 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.303 | UHRF1 is phosphorylated by CDK2/cyclin A. In vitro kinase assay was performed with CDK2/cyclin A using recombinant wild-type UHRF1 or UHRF1-S674A mutant | SIGNOR-277192 |
P25490 | P38606 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.325 | We investigated the relationship between transcription factor YY1 and ATP6V1A, and found that mRNA expression of YY1 had significant correlation with that of ATP6V1A. To validate that YY1 transcriptionally regulates ATP6V1A, we discovered that the ATP6V1A core promoter region contains three YY1 binding sites. Moreover,... | SIGNOR-260635 |
P08754 | P32239 | 2 | binding | up-regulates activity | 0.267 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257150 |
P31751 | P15311 | 1 | phosphorylation | up-regulates | 0.375 | Purified akt directly phosphorylates recombinant ezrin at threonine 567 in vitro in an atp-dependent manner. ezrin activation after initiation of na+-glucose cotransport requires akt2 expression | SIGNOR-130260 |
P04150 | P06239 | 2 | binding | up-regulates | 0.355 | The present study shows that the GC receptor is part of a TCR-linked multiprotein complex containing heat-shock protein (HSP)90, LCK and FYN, which is essential for TCR-dependent LCK/FYN activation. | SIGNOR-251685 |
Q9Y4D8 | P01106 | 2 | ubiquitination | down-regulates quantity by destabilization | 0.2 | We identified several E3 ligases as strong candidates responsible for AR and MYC protein loss as HECTD4, MYCBP2, and TRIM49. HECTD4 and MYCBP2 target AR and MYC for degradation while TRIM49 appears to promote AR and MYC stability. We have shown that these E3 ligases in turn are directly regulated by MYC. MYC in turn r... | SIGNOR-267146 |
P12931 | P15529 | 1 | phosphorylation | up-regulates activity | 0.458 | Src kinase phosphorylates CD46 at Y354 of the Cyt2 isoform in vitro. | SIGNOR-280127 |
Q5S007 | O43353 | 1 | phosphorylation | up-regulates activity | 0.376 | Altogether, our results indicate a scenario that LRRK2 physically interacts with Rip2 and promotes phosphorylation of Rip2.|Taken together, our results show that LRRK2 enhances Rip2 activity by promoting the phosphorylation of Rip2 at Ser176. | SIGNOR-278953 |
Q96PM5 | Q9UQM7 | 0 | phosphorylation | down-regulates | 0.296 | Phosphorylation of pirh2 by calmodulin-dependent kinase ii impairs its ability to ubiquitinate p53 | SIGNOR-156064 |
P04626 | Q96JA1 | 0 | ubiquitination | down-regulates | 0.403 | We report upregulation of lrig1 transcript and protein upon egf stimulation, and physical association of the encoded protein with the four egfr orthologs of mammals. Upregulation of lrig1 is followed by enhanced ubiquitylation and degradation of egfr. The underlying mechanism involves recruitment of c-cbl, an e3 ubiqui... | SIGNOR-139948 |
P31751 | P55265 | 1 | phosphorylation | down-regulates activity | 0.2 | AKT-dependent phosphorylation of the adenosine deaminases ADAR-1 and -2 inhibits deaminase activity. Coimmunoprecipitation studies and in vitro kinase assays revealed that AKT-1, -2, and -3 interact with both ADAR1p110 and ADAR2 and phosphorylate these RNA editases. Using site-directed mutagenesis of suspected AKT phos... | SIGNOR-276192 |
P29320 | Q8NBZ7 | 1 | phosphorylation | up-regulates activity | 0.2 | However, it is possible that etk is a principal activator of Ugd.|The phosphorylation of the Ugd protein (a UDP-glucose dehydrogenase) by Etk increases Ugd dehydrogenase activity. | SIGNOR-280006 |
Q8TDC3 | Q8N5S9 | 0 | phosphorylation | up-regulates activity | 0.307 | In transfected COS-7 cells, kinase activity and Thr (189) phosphorylation of overexpressed SAD-B were significantly enhanced by coexpression of constitutively active CaMKKalpha (residues 1-434) in a manner similar to that observed with coexpression of LKB1, STRAD, and MO25.|Taken together, these results indicate that C... | SIGNOR-280202 |
P46531 | Q13573 | 2 | binding | up-regulates | 0.601 | Contact with skip is required for biological activity of notchic. A mutation in the fourth ankyrin repeat that abolished notch signal transduction did not affect interaction with cbf1 but abolished interaction with skip. | SIGNOR-86125 |
P04626 | Q15303 | 2 | binding | up-regulates | 0.53 | Most breast, skin, lung, ovary, and gastrointestinal tract tumors express erbb-4, and heterodimerization of this receptor with erbb-2, may be involved in some cancer | SIGNOR-43844 |
P24941 | O94761 | 1 | phosphorylation | up-regulates activity | 0.329 | During S/G2 phases, CDK1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction and RECQL4 recruitment to DSBs. | SIGNOR-277374 |
Q9H422 | Q00613 | 1 | phosphorylation | up-regulates activity | 0.335 | We show that Yak1 directly phosphorylates Hsf1 in vitro, leading to the increase in DNA binding activity of Hsf1. | SIGNOR-279054 |
P36888 | P49771 | 2 | binding | up-regulates | 0.885 | Flt3 ligand (fl) is an early-acting potent co-stimulatory cytokine that regulates proliferation and differentiation of a number of blood cell lineages. Its receptor flt3/flk2 belongs to class iii receptor tyrosine kinases that also include the receptors for colony-stimulating factor 1 | SIGNOR-65564 |
Q9UBY5 | P19086 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257229 |
P10071 | P55075 | 1 | transcriptional regulation | down-regulates quantity | 0.445 | Whereas Fgf8 expression was almost absent in Shh-/- mutants, it was up-regulated in Gli3-/-;Shh-/- double mutants, suggesting that SHH is not required for Fgf8 induction, and that GLI3 normally represses Fgf8 independently of SHH | SIGNOR-268949 |
Q92908 | P49840 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.265 | Through bioinformatics and cell-based experiments, we identified the AKT-repressed signal as glycogen synthase kinase 3 (GSK3)-catalyzed phosphorylation of Ser(37) on the long form of the transcription factor GATA6. Phosphorylation of GATA6 on Ser(37) promoted its degradation, thereby preventing GATA6 from repressing t... | SIGNOR-253156 |
Q9NXA8 | P07195 | 1 | deacetylation | up-regulates activity | 0.2 | In colorectal cancer, SIRT5 binds to lactate dehydrogenase B (LDHB) to deacetylate it at Lysine 329, thereby increasing its enzymatic activity. | SIGNOR-267645 |
P53779 | Q5JR12 | 1 | phosphorylation | down-regulates | 0.2 | Specific phosphorylation of pp2czeta at ser (92) by stress-activated jnk attenuates its phosphatase activity in cells. | SIGNOR-178926 |
Q99497 | P31749 | 0 | phosphorylation | up-regulates activity | 0.465 | Using a proteomic approach, we identified on DJ-1 a novel threonine phosphorylation (T125) that was found, by the in-silico tool scansite 4, as part of a putative Akt consensus. |Deglycase activity of DJ-1 on histones proteins, investigated by coupling 2D tau gel with LC-MS/MS and 2D-TAU (Triton-Acid-Urea)-Western blot... | SIGNOR-275582 |
P50148 | P41595 | 2 | binding | up-regulates activity | 0.553 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257138 |
P63211 | Q9NPG1 | 2 | binding | up-regulates | 0.398 | In the non-canonical wnt signalling pathway, frizzled uses galphaq or galphai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat. | SIGNOR-152606 |
Q00536 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.335 | Taken together, our findings demonstrate that Pctaire1 interacts with p35, both in vitro and in vivo, and that phosphorylation of Pctaire1 by Cdk5 enhances its kinase activity. | SIGNOR-279149 |
P78357 | Q13882 | 0 | phosphorylation | up-regulates activity | 0.2 | As a consequence, Brk stimulates p190 and attenuates p120 functions, leading to RhoA inactivation and Ras activation, respectively.|Brk phosphorylates p190 at the Y (1105) residue both in vitro and in vivo, thereby promoting the association of p190 with p120RasGAP (p120). | SIGNOR-279274 |
P05107 | O60674 | 0 | phosphorylation | up-regulates activity | 0.265 | PTKs of the JAK and SRC families have a regulatory role in LFA-1 affinity triggering, with JAKs showing a positive role (3), whereas SRCs possibly have a negative role. | SIGNOR-254738 |
Q86Y13 | Q9BTM1 | 1 | monoubiquitination | up-regulates activity | 0.2 | 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TL... | SIGNOR-271763 |
Q01484 | O94856 | 0 | relocalization | up-regulates quantity | 0.694 | Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with... | SIGNOR-266716 |
Q13608 | O43933 | 2 | binding | up-regulates activity | 0.67 | Pex26 recruits Pex6–Pex1 complexes to peroxisomes. Pex26 anchors Pex6 and Pex1 through Pex26–Pex6 and Pex6–Pex1 interactions. | SIGNOR-253615 |
Q02750 | Q16584 | 0 | phosphorylation | up-regulates activity | 0.335 | Here we report that MLK3 can phosphorylate and activate MEK-1 directly in vitro and also can induce MEK phosphorylation on its activation sites in vivo in COS-7 cells. | SIGNOR-280019 |
P20810 | P07384 | 2 | binding | down-regulates activity | 0.915 | In addition to Ca2+, calpastatin has a key role in the regulation of calpain. Calpastatin, a heat-stable protein ranging from ~70 to ~140 kDa of apparent molecular weight depending on the cell type, is considered a specific endogenous inhibitor of calpains|The calpastatin molecule contains four inhibitory units [75–77]... | SIGNOR-251582 |
P11802 | Q14814 | 2 | binding | down-regulates | 0.28 | In contrast to cdk2, cyclin d/cdk4 blocks myod activity through an as yet unclear mechanism that may involve direct binding. Cyclin d/cdk4 can also block the activity of myogenin and all mef2 isoforms. | SIGNOR-176524 |
Q9UGL1 | P78317 | 0 | sumoylation | down-regulates quantity by destabilization | 0.3 | Hendriks and coworkers showed that, in response to alkylation damage by methyl methanesulfonate (MMS), SUMOylated JARID1B (KDM5B) is ubiquitylated by the SUMOtargeted ubiquitin ligase RNF4 and degraded by the proteasome, whereas JARID1C (KDM5C) is SUMOylated and recruited to the chromatin to demethylate histone H3K4 (H... | SIGNOR-271575 |
P08151 | P28482 | 0 | phosphorylation | up-regulates activity | 0.323 | We conclude that multisite phosphorylation of GLI1 by ERK2 or other MAP kinases weakens GLI1-SUFU binding, thereby facilitating GLI1 activation and contributing to both physiological and pathological crosstalk. | SIGNOR-277601 |
P08908 | Q00535 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.27 | Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT 1A receptor via phosphorylation|5-HT1AR was phosphorylated by the Cdk5-p35 complex at Thr314 in the third cytoplasmic loop. | SIGNOR-264406 |
P0DTD1-PRO_0000449619 | P23396 | 2 | binding | down-regulates activity | 0.2 | Nsp1 Locks the 40S in a Conformation Incompatible with mRNA Loading and Disrupts Initiation Factor Binding. Molecular interactions between C-Nsp1 and 40S ribosome components, including uS3, h18, and uS5. | SIGNOR-262507 |
P37173 | P10600 | 2 | binding | up-regulates | 0.866 | T?RII Is known to bind the isoforms tgf??1 And tgf??3. Binding of these ligands causes recruitment of the type i receptor (t?RI) into a signalling receptor complex followed by activation of t?RI Through transphosphorylation | SIGNOR-104798 |
P31749 | O60858 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.353 | Here, we demonstrate that overexpression of RFP2 in cells induced apoptosis through proteasomal degradation of MDM2 and AKT. We observed that RFP2 formed a complex with MDM2, a negative regulator of the p53 tumor suppressor, and AKT, a regulator of apoptosis inhibition at the cellular level. Additionally, we found tha... | SIGNOR-271852 |
Q8WXX7 | Q8TCU6 | 2 | binding | up-regulates activity | 0.252 | Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic AUTS2 is involved in the reg... | SIGNOR-266817 |
Q13588 | P00519 | 2 | binding | up-regulates | 0.267 | We show that the grb2-related adapter protein, gads, also associates with bcr-abl, specifically through y177 and demonstrate that bcr-abl-driven lymphoid disease requires gads | SIGNOR-200871 |
Q01094 | P45983 | 0 | phosphorylation | down-regulates activity | 0.277 | JNK1 phosphorylates E2F1 in vitro, and co-transfection of JNK1 reduces the DNA binding activity of E2F1 | SIGNOR-279218 |
P67775 | P63151 | 2 | binding | down-regulates activity | 0.912 | Since B_ suppresses the association of the catalytic C and regulatory A subunits of protein phosphatase 2A [94], the B_ interaction with the receptor is expected to result in enhanced protein phosphatase 2A activity | SIGNOR-217875 |
Q96A08 | Q14493 | 0 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265393 |
P29597 | P08575 | 0 | dephosphorylation | down-regulates activity | 0.407 | CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling|these results show that CD45 dephosphorylates functionally important tyrosine residues. It should be noted that, as with our phosphatase assays in vitro, Tyr 1022 and Tyr 1023 of JAK1, Tyr 1007 and Tyr 1008 of JAK2, and Tyr 1054 and Tyr 105... | SIGNOR-248357 |
Q9H461 | P04628 | 2 | binding | up-regulates | 0.725 | Wnt signaling is mediated by the frizzled (fz) family of seven-pass transmembrane receptors that bind wnt via the conserved amino-terminal cysteine-rich domain (crd) | SIGNOR-109250 |
P60900 | P17861 | 2 | binding | down-regulates quantity by destabilization | 0.303 | We saw preferential binding of XBP-1u to subunits _5, _6 and _7.2. We demonstrate that XBP-1u undergoes efficient degradation in vitro by 20S proteasomes in the absence of ubiquitination. | SIGNOR-239039 |
P0CG48 | Q9BXM7 | 0 | phosphorylation | up-regulates activity | 0.604 | Ubiquitin is phosphorylated by PINK1 to activate parkin|PINK1 phosphorylated ubiquitin at Ser65 both in vitro and in cells | SIGNOR-249691 |
Q86Y13 | Q6FI13 | 1 | monoubiquitination | up-regulates activity | 0.2 | 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TL... | SIGNOR-271755 |
Q9BXW9 | P51587 | 2 | binding | up-regulates activity | 0.812 | Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction | SIGNOR-263238 |
O15027 | P28482 | 0 | phosphorylation | up-regulates activity | 0.352 | Recombinant active ERK2 also phosphorylated Sec16 (XREF_FIG). | SIGNOR-280022 |
Q9Y5G0 | Q9Y5H9 | 2 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265692 |
P23588 | P31749 | 0 | phosphorylation | up-regulates | 0.393 | Using an in vitro kinase assay, we found that pkb can directly phosphorylate eif4b on serine 422 (ser422). This was prevented by pretreatment of cells with the phosphatidylinositol 3-kinase (pi3k) inhibitor ly294002 or pharmacological inhibition of pkb. Phosphorylation regultes the activation of eukaryotic translation ... | SIGNOR-252520 |
Q13315 | Q9UQ84 | 1 | phosphorylation | up-regulates | 0.83 | The phosphorylation of exo1 by atm appears to regulate the activity of exo1 following resection, allowing optimal rad51 loading and the completion of hr repair. | SIGNOR-162304 |
P24864 | P24941 | 2 | binding | up-regulates | 0.955 | Our results suggest that ad-induced cyclin e activates cdk2 that targets the transcriptional repressor prb/cyclin e activates the cdk2 kinase necessary for the actual initiation of dna replication | SIGNOR-201506 |
P28482 | Q8IUX7 | 1 | phosphorylation | up-regulates activity | 0.2 | We show that DNA binding by AEBP1 requires both the N- and C-terminal domains of AEBP1, and MAPK interaction with AEBP1 (through its N terminus) results in enhanced DNA binding. A threonine at position 623 within the C-terminal domain of AEBP1 plays an important role in DNA binding by AEBP1, because the mutation result... | SIGNOR-262897 |
Q9NR19 | P11279 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy|A chromatin immunoprecipitation (ChIP) assay with antibodies against TFEB or ACSS2 demonstrated that glucose deprivation results in the binding of TFEB (Figure 3D) and ACSS2 (Figure 3E) to the promoter regions of CTSA, GBA, GU... | SIGNOR-276556 |
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