IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q9Y5B0 | P30291 | 1 | dephosphorylation | up-regulates activity | 0.382 | At mitosis exit, Fcp1 promoted inhibitory Cdk1 phosphorylation by dephosphorylating Wee1, and ubiquitin dependent cyclin B degradation by dephosphorylating Cdc20 and USP44.|This lead us to hypothesize that, during prolonged mitosis in AMCDs treated cancer cells, progressive Fcp1 induced Wee1 reactivation might lead to ... | SIGNOR-277142 |
Q05513 | O95863 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | APKC kinases phosphorylate S249 of SNAI1, which leads to protein degradation. | SIGNOR-277437 |
P56962 | Q9H714 | 2 | binding | up-regulates activity | 0.2 | Under nutrient-rich conditions, mTORC1 phosphorylates Pacer at serine157 to disrupt the association of Pacer with Stx17 and the HOPS complex and thus abolishes Pacer-mediated autophagosome maturation. These results demonstrate that mTORC1-mediated Pacer phosphorylation at S157 inhibits autophagosome maturation by disru... | SIGNOR-273684 |
Q99538 | P07900 | 2 | binding | up-regulates quantity by stabilization | 0.2 | We demonstrate that TRAF6 ubiquitinates the proform of AEP through K63-linked polyubiquitin, reversible by USP17, and forms a complex with HSP90α to subsequently promote pro-AEP intracellular stability as well as secretion. We now present evidence that AEP is a substrate for TRAF6 ubiquitination, resulting in AEP/TRAF6... | SIGNOR-272855 |
P0C0S8 | Q5FBB7 | 1 | relocalization | up-regulates activity | 0.2 | The complex between shugoshin and protein phosphatase 2A (Sgo1-PP2A) localizes to centromeres in mitosis, binds to cohesin in a reaction requiring Cdk-dependent phosphorylation of Sgo1, dephosphorylates cohesin-bound sororin, and protects a centromeric pool of cohesin from mitotic kinases and the cohesin inhibitor Wapl... | SIGNOR-265262 |
Q7Z434 | Q14164 | 2 | binding | up-regulates activity | 0.832 | After ligand binding, cGAS and RIG-I signal through respective adaptor proteins STING and MAVS to recruit the kinases IKK and TBK1, which then activate the transcription factors NF-κB and interferon regulatory factor 3 (IRF3), respectively. | SIGNOR-260144 |
Q13322 | P06213 | 2 | binding | down-regulates | 0.66 | Grb10 negatively regulates growth factor signaling. It binds the insulin and insulin-like growth factor 1 (igf-1) receptors;mice without grb10 are larger and exhibit enhanced insulin sensitivity. | SIGNOR-174065 |
Q16620 | Q92529-2 | 1 | phosphorylation | up-regulates activity | 0.755 | We also obtained tryptic phosphopeptide maps of N-Shc protein phosphorylated in vitro by other tyrosine kinases, TrkB, v-Src and EGFR. The overall patterns of the phosphopeptide maps generated by these tyrosine kinases were similar, although there were some differences among these maps (Figure 4a–d).We performed phosph... | SIGNOR-273917 |
Q9UQF2 | Q12851 | 2 | binding | down-regulates | 0.2 | DLK mutants were used to demonstrate that a DLK leucine zipper-leucine zipper interaction is necessary for DLK dimerization and to show that DLK dimerization mediated by the leucine zipper domain is prerequisite for DLK activity and subsequent activation of stress-activated protein kinase (SAPK). | SIGNOR-75385 |
Q14344 | Q9NZN5 | 2 | binding | up-regulates activity | 0.772 | P115 RhoGEF stimulates the intrinsic GTP hydrolysis activity of G alpha 12/13 subunits and acts as an effector for G13-coupled receptors by linking receptor activation to RhoA activation. | SIGNOR-256519 |
O00303 | P21127 | 0 | phosphorylation | up-regulates activity | 0.515 | EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis. | SIGNOR-273133 |
P11802 | Q8IZL8 | 1 | phosphorylation | up-regulates | 0.351 | Using site-directed mutagenesis and in vitro kinase assays, we identified ser(477) and ser(991) of pelp1 as cdk phosphorylation sites. we identified pelp1 as a novel substrate of cdks and found that cdk phosphorylation is important for the proper function of pelp1 in modulating hormone-driven cell cycle progression an... | SIGNOR-167770 |
O43318 | Q9Y572 | 1 | phosphorylation | up-regulates activity | 0.2 | Collectively, TAK1 activates RIPK3, RIPK3 activates TAK1, and RIPK1 activates RIPK3 and facilitates interaction between TAK1 and RIPK3.|We found that prolonged and hyperactivation of TAK1 induced phosphorylation and activation of RIPK3, leading to necrosis without caspase activation. | SIGNOR-279634 |
Q9H714 | P56962 | 2 | binding | up-regulates activity | 0.2 | Under nutrient-rich conditions, mTORC1 phosphorylates Pacer at serine157 to disrupt the association of Pacer with Stx17 and the HOPS complex and thus abolishes Pacer-mediated autophagosome maturation. These results demonstrate that mTORC1-mediated Pacer phosphorylation at S157 inhibits autophagosome maturation by disru... | SIGNOR-273684 |
P84022 | O15105 | 0 | transcriptional regulation | down-regulates quantity | 0.613 | The downstream molecules including mad2, smad3, smad4 and smad7 are involved in TGF-β1-induced EMT,while Smad7 blocks the smad3 expression | SIGNOR-260437 |
Q14790 | P29350 | 0 | dephosphorylation | up-regulates activity | 0.354 | Caspase-8 is tyrosine-phosphorylated in freshly isolated neutrophils but spontaneously dephosphorylates in culture, in association with the progression of constitutive apoptosis. Phosphorylation of caspase-8 on Tyr-310 facilitates its interaction with the Src-homology domain 2 containing tyrosine phosphatase-1 (SHP-1) ... | SIGNOR-248478 |
P00519 | P40763 | 1 | phosphorylation | up-regulates activity | 0.445 | Previously, we showed that c-Abl and Arg promote phosphorylation of the STAT3 transcription factor (Y705) in a variety of cancer cell lines , .|Since c-Abl and Arg activate STAT3, we investigated whether c-Abl and Arg regulate NF-kappaB signaling. | SIGNOR-279675 |
O15503 | Q8WU17 | 0 | ubiquitination | down-regulates quantity | 0.477 | TRC8/RNF139 encodes an endoplasmic reticulum-resident E3 ubiquitin ligase that inhibits growth in a RING- and ubiquitylation-dependent manner. TRC8 also contains a predicted sterol-sensing domain. Here, we report that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endop... | SIGNOR-271955 |
P19784 | Q8N163 | 1 | phosphorylation | up-regulates activity | 0.2 | CK2alphawas bound to DBC1 and phosphorylated DBC1. The phosphorylation of DBC1 by CK2alphawas evidenced by co-immunoprecipitation of CK2alphaand DBC1 in a GST pull-down assay, an in vitro kinase assay, and immunofluorescence staining. |In our results, CK2alpha affected the|These results suggest that DBC1 may be involve... | SIGNOR-267667 |
P41968 | Q8TCY5 | 2 | binding | down-regulates activity | 0.474 | We report that MRAP and MRAP2 can interact with all 5 MCRs. This interaction results in MC2R surface expression and signaling. In contrast, MRAP and MRAP2 can reduce MC1R, MC3R, MC4R, and MC5R responsiveness to [Nle4,D-Phe7]alpha-melanocyte-stimulating hormone (NDP-MSH). MRAP and MRAP2 can reduce the surface expression... | SIGNOR-252366 |
P38936 | P31751 | 2 | binding | down-regulates activity | 0.682 | Whereas akt1 phosphorylates p21, inducing its release from cdk2 and cytoplasmic localization as previously described for akt, akt2 binds p21 in the region spanning the t145 site of p21, thus competing with phosphorylation by akt1 and inducing its accumulation in the nucleus. These distinct roles of akt/pkb isoforms in ... | SIGNOR-149705 |
Q06124 | P32927 | 1 | dephosphorylation | up-regulates | 0.511 | Shp2 is thought to act as a positive mediator of growth factor signals.. Hp2 could act as an adaptor between the activated c and grb2, thus leading to activation of the ras/mitogen-activated protein kinase pathway, known to be activated by il-3 | SIGNOR-48557 |
P25098 | P00533 | 0 | phosphorylation | up-regulates activity | 0.2 | Previous studies showed that EGFR activation results in association of GRK2 with the EGFR and subsequent phosphorylation of GRK2 at three tyrosine residues (Tyr 13, -86, and -92), resulting in activation of GRK2.|We propose that GRK2 activation by EGFR leads to GRK2 phosphorylation of Mst2 at these sites, which, in tur... | SIGNOR-279368 |
P53350 | Q14674 | 1 | phosphorylation | down-regulates activity | 0.772 | Although mutation of serine 1126 and threonine 1346 to alanine had no effect (lanes 2 and 5), additional mutation of threonine 1363 and serine 1399 rendered separase almost completely resistant to phosphorylation (lane 3). Serine 1399 seems to be the one residue within this large separase fragment that is most efficien... | SIGNOR-276082 |
P31749 | A8MYZ6 | 1 | phosphorylation | down-regulates | 0.648 | The phosphorylation of the two remaining akt-dependent sites inhibits foxo6 transcriptional activity | SIGNOR-252582 |
Q04759 | Q00613 | 1 | phosphorylation | up-regulates | 0.349 | At the same time, ea causes pkc?-Mediated phosphorylation and activation of the transcription factor heat shock factor 1, an inducer of glucose dependence. | SIGNOR-200576 |
Q8N3Y1 | P24385 | 2 | binding | down-regulates quantity by destabilization | 0.511 | We next investigated whether in vitro ubiquitination of cyclin D1 through the SCF-like (SCFL) complex FBXW8 (SKP1-CUL7-FBXW8-RBX1/SCFLFBXW8) requires phosphorylation of cyclin D1 at Thr286 (Fig. 3F). Polyubiquitination through SCFLFBXW8 was dramatically reduced by the depletion of ERK2 (lane 2). Furthermore, cyclin D1 ... | SIGNOR-271624 |
Q9NYV6 | P45984 | 0 | phosphorylation | down-regulates | 0.472 | Inactivation is due to phosphorylation of tif-ia by c-jun n-terminal kinase (jnk) at a single threonine residue (thr 200). Phosphorylation at thr 200 impairs the interaction of tif-ia with pol i and the tbp-containing factor tif-ib/sl1, thereby abrogating initiation complex formation. | SIGNOR-134878 |
P08754 | Q96LB2 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257171 |
Q99717 | Q13464 | 0 | phosphorylation | up-regulates activity | 0.306 | The results showed that SMAD5 was directly phosphorylated at Ser463/465 by ROCK1 (Fig.\u00a04g).|These data indicated that the activation of SMAD5 induced by TEM8 was mediated directly by the RhoC/ROCK1 pathway.To evaluate the effect of SMAD5 on the cellular functions of TEM8, SMAD5 was knockdown in TEM8-overexpressi... | SIGNOR-280107 |
Q16611 | Q16611 | 2 | binding | up-regulates | 0.2 | Allosteric activation of bak induces its intramembranous oligomerization into a proposed pore for cytochrome c efflux | SIGNOR-105203 |
Q05655 | Q00535 | 1 | phosphorylation | down-regulates activity | 0.2 | This generates a binding site for the C2 domain of PKCδ, which in turn phosphorylates CDK5 on T77. The resulting dissociation of the CDK5R1/CDK5 complex abolishes the activity of CDK5. | SIGNOR-277386 |
Q96TA1 | P15056 | 0 | phosphorylation | down-regulates activity | 0.2 | Overall, this indicates that BRAF-dependent phosphorylation of FAM129B controls its cellular localization and thus its ability to bind to KEAP1 to block NRF2 degradation. | SIGNOR-279595 |
Q9BYW2 | P68431 | 1 | trimethylation | up-regulates activity | 0.2 | Our results suggest that HYPB HMTase may coordinate histone methylation and transcriptional regulation in mammals and open perspective for the further study of the potential roles of HYPB protein in hematopoiesis and pathogenesis of HD. | SIGNOR-269071 |
Q96KS0 | Q969H0 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.349 | Mechanistically, we further show that FBW7, an E3 ligase complex component that is frequently downregulated in TNBC, negatively regulates EglN2 protein stability. | SIGNOR-261997 |
Q8WZ74 | Q14247 | 2 | binding | up-regulates activity | 0.511 | Fluorescence recovery after photobleaching further suggested that CTTNBP2 modulates the mobility of cortactin in neurons. CTTNBP2 may thus help to immobilize cortactin in dendritic spines and control the density of dendritic spines. | SIGNOR-269703 |
P04626 | P43378 | 0 | dephosphorylation | down-regulates activity | 0.304 | Conversely, increasing expression of PTPN9 wild type (WT) inhibits tyrosyl phosphorylation of ErbB2 and EGFR.|Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells. | SIGNOR-277170 |
P27361 | Q07889 | 1 | phosphorylation | down-regulates | 0.636 | For example, inactivation of sos through phosphorylation by the downstream mapk | SIGNOR-26338 |
O00444 | Q9HC77 | 1 | phosphorylation | up-regulates | 0.799 | Plk2 phosphorylates the s589 and s595 residues of cpap in vitro and in vivo. This phosphorylation is critical for procentriole formation during the centrosome cycle. Plk4 also phosphorylates s595 of cpap | SIGNOR-166007 |
Q96BR1 | Q13045 | 1 | phosphorylation | up-regulates | 0.355 | Here we show that flii is an in vivo substrate of cisk that functions downstream of pi 3-kinase. Cisk can associate with flii and phosphorylate flii at residues ser(436) and thr(818).We demonstrate here that cisk can enhance er transcription, which is dependent on its kinase activity, and mutation of cisk phosphorylati... | SIGNOR-184688 |
Q8IZL9 | Q15910 | 1 | phosphorylation | up-regulates activity | 0.2 | In addition to the transcriptional feedback loop, we also identified a feed-forward loop in which CCRK induces EZH2 phosphorylation, thereby promoting p-EZH2 Ser21 -AR physical interaction for CCRK promoter co-occupancy and transcriptional activation. | SIGNOR-279017 |
P01100 | P59595 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | The transcription factors c-Fos, FosB, CREB-1, and ATF2 were all activated by the addition of SARS-CoV N protein to the sample well | SIGNOR-260726 |
P38936 | Q9Y463 | 0 | phosphorylation | up-regulates activity | 0.258 | Mirk exerts its anti-apoptotic effects during muscle differentiation at least in part through effects on the cell cycle inhibitor and pro-survival molecule p21cip1. Overexpression and rna interference experiments demonstrated that mirk phosphorylates p21 within its nuclear localization domain at ser-153 causing a porti... | SIGNOR-235635 |
Q9UNZ2 | P06493 | 0 | phosphorylation | down-regulates activity | 0.325 | Now, we have found that p47, which mainly localizes to the nucleus during interphase, is phosphorylated on serine-140 by cdc2 at mitosis. The phosphorylated p47 does not bind to golgi membranes. | SIGNOR-102350 |
Q9NQX3 | O43307 | 2 | binding | up-regulates activity | 0.604 | Gephyrin is believed to act as a scaffold at inhibitory synapses, in a manner analogous to that of the prototypic excitatory synaptic scaffold, PSD-95. The best-known function of gephyrin is to bring the inhibitory synaptic receptors and to stabilize them at the inhibitory synapses. gephyrin interacts with NL-2 and col... | SIGNOR-264973 |
P06213 | P06213 | 2 | phosphorylation | up-regulates activity | 0.2 | We identified the major autophosphorylation sites in the insulin receptor and correlated their phosphorylation with the phosphotransferase activity of the receptor on synthetic peptides. We conclude that 1) autophosphorylation of the insulin receptor begins by phosphorylation of Tyr-1146 and either Tyr-1150 or Tyr-1151... | SIGNOR-106510 |
P51608 | P46531 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.29 | As the first step to reveal how MeCP2 phosphorylation may regulate Notch signaling, we conducted chromatin immunoprecipitation (ChIP) experiment to determine whether the phosphor-mutant MeCP2 protein has altered promoter occupancy at the promoters of Dll1 and Notch1. We found increased binding of the phosphor-mutant pr... | SIGNOR-264675 |
Q13148 | Q9UPY3 | 1 | post transcriptional regulation | up-regulates quantity | 0.374 | Molecularly, we observed that TBPH regulates the expression levels of Dicer-2 by direct protein-mRNA interactions in vivo.|In agreement with this idea, we found that the suppression of TDP-43 induces the downregulation of Dicer in human neuroblastoma cell lines signifying that the TDP-43 function is required to prevent... | SIGNOR-262114 |
Q9C026 | P62837 | 2 | binding | up-regulates activity | 0.425 | Collectively, these results indicated that TRIM9 is an E3 ligase for its self-ubiquitination and that the ubiquitination of TRIM9 likely serves as a signal for proteasomal degradation. As shown in Fig. 1A, TRIM9 was ubiquitinated by itself when incubated with UbcH5b. In contrast, ubiquitination was observed when incuba... | SIGNOR-271420 |
P23470 | P16234 | 1 | dephosphorylation | up-regulates activity | 0.249 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254714 |
Q13554 | Q9H6L5 | 1 | phosphorylation | up-regulates activity | 0.2 | Under ER-stress conditions, activated CAMK2B phosphorylates the reticulon-homology domain of FAM134B, which enhances FAM134B oligomerization and activity in membrane fragmentation to accommodate high demand for ER-phagy. | SIGNOR-273554 |
P38405 | P43088 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256953 |
O15105 | P62136 | 2 | binding | up-regulates | 0.429 | Smad7, induced by alk1 activation, recruits pp1? To alk1 and thereby inhibits tgf-?/Alk1-induced smad1/5 phosphorylation in ecs | SIGNOR-145389 |
P17252 | P43405 | 0 | phosphorylation | up-regulates activity | 0.391 | We present evidence that Tyr-662 and Tyr-658 of PKCbetaI and PKCalpha, respectively, are phosphorylated by Syk in the membrane compartment of FcepsilonRI-stimulated mast cells. These phosphorylations require prior PKC autophosphorylation of the adjacent serine residues (Ser-661 and Ser-657, respectively) and generate a... | SIGNOR-246581 |
Q06330 | O14641 | 2 | binding | down-regulates activity | 0.269 | Mechanistically, Dishevelled binds and directly inhibits CSL transcription factors downstream of Notch receptors, reducing their activity. Furthermore, our data suggest that this crosstalk mechanism is conserved between vertebrate and invertebrate homologues. Thus, we identify a dual function for Dishevelled as an inhi... | SIGNOR-243999 |
Q8NEV1 | Q99250 | 1 | phosphorylation | up-regulates activity | 0.2 | We found that the ankyrin-binding motif of Na(v)1.2 that determines channel concentration at the AIS depends on a glutamate residue (E1111), but also on several serine residues (S1112, S1124, and S1126). We showed that phosphorylation of these residues by protein kinase CK2 (CK2) regulates Na(v) channel interaction wit... | SIGNOR-275755 |
Q13547 | P00519 | 0 | phosphorylation | up-regulates activity | 0.507 | Despite the fact that HDAC1 was phosphorylated by co-expression with c-Abl, stabilization of HDAC1 by c-Abl was not affected by mutations in its sites phosphorylated by c-Abl.|c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity dependent manner. | SIGNOR-280169 |
Q05513 | P10636-2 | 1 | phosphorylation | down-regulates activity | 0.268 | We have studied the relationship between the phosphorylation oftau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. By contrast, MARK and PKA phosphorylate several sites within the repeats (notably theKXGS motifs including Ser262, Ser324, and Ser356, plus Ser320); in addition PKA phosphorylates so... | SIGNOR-275447 |
Q12756 | P0DP24 | 2 | binding | up-regulates activity | 0.261 | To better understand how KIF1A-driven dense core vesicle (DCV) transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium binding protein calmodulin (CaM) and two synaptic scaffolding proteins: liprin-α and TANC2. We showed that calcium, acting via CaM, enhances KIF1A... | SIGNOR-266889 |
P52272 | Q99459 | 2 | binding | up-regulates activity | 0.635 | hnRNP-M interacts directly with CDC5L and PLRG1 in vivo. we investigated whether the function of hnRNP-M in alternative splicing was affected by the central region mapped as essential for binding to the CDC5L/PLRG1 proteins. We conclude that loss of the CDC5L/PLRG1 interaction domain in hnRNP-M correlates with a loss ... | SIGNOR-239410 |
P08047 | P28482 | 0 | phosphorylation | up-regulates | 0.644 | Here we show that p42/p44 mapk directly phosphorylates sp1 on threonines 453 and 739 both in vitro and in vivo. Mutation of these sites to alanines decreases by half the mapk-dependent transcriptional activity of sp1. Phosphorylated extracellular signal-regulated protein kinases 1 and 2 phosphorylate sp1 on serine 59 a... | SIGNOR-116158 |
Q2T9J0 | Q2T9J0 | 2 | cleavage | down-regulates activity | 0.2 | Self-cleavage of Tysnd1 in the active oligomer most likely inactivates its protease activity. Subsequently, the cleaved products are degraded by PsLon and removed from the Tysnd1 oligomer. | SIGNOR-261053 |
Q92993 | P35790 | 1 | acetylation | up-regulates activity | 0.2 | Glucose deprivation induces the binding of choline kinase α2 (CHKα2) to lipid droplets, followed by a continuous PTMs to promote lipolysis of lipid droplets, which are in turn mediated by AMPK-dependent CHKα2 Serine 279 phosphorylation and KAT5-dependent CHKα2 Lysine 247 acetylation. | SIGNOR-267648 |
P42574 | P25963 | 1 | cleavage | up-regulates quantity by stabilization | 0.422 | The cell-death protease cpp32 (caspase-3) in vitro specifically cleaved chicken and human ikappab-alpha at a conserved asp-ser sequence.Therefore, cleavage of I_B-_ by a CPP32-like protease could create what is sometimes called a super-repressor form of I_B-_ (20). That is, cleavage by CPP32 would block the ability of ... | SIGNOR-51936 |
P17612 | Q00613 | 1 | phosphorylation | up-regulates | 0.314 | Protein kinase a binds and activates heat shock factor 1hsf1 binds avidly to the catalytic subunit of pka, (pkac_) and becomes phosphorylated on a novel serine phosphorylation site within its central regulatory domain (serine 320 or s320), both in vitro and in vivo. Intracellular pkac_ levels and phosphorylation of hsf... | SIGNOR-169853 |
P56279 | P31751 | 2 | binding | up-regulates | 0.547 | Full-length tcl1 and its isoforms bind to akt / in in vitro kinase assays using gsk-3_ as a substrate, we found that the presence of any of the tcl1 family proteins (tcl1, mtcp1, or tcl1b) as gst fusion proteins significantly enhanced akt-induced gsk-3_ phosphorylation | SIGNOR-81683 |
Q13485 | P01106 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.64 | Down-regulation of c-Myc is a critical event for growth inhibition induced by transforming growth factor-β (TGF-β) and is frequently impaired in cancer cells. We determined a Smad-responsive element in the c-mycpromoter. | SIGNOR-251493 |
Q15077 | Q03113 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257343 |
Q13131 | Q9NP71 | 1 | phosphorylation | down-regulates | 0.451 | Ampk has also been suggested to phosphorylate the glucose-sensitive transcription factor chrebpthe dna binding activity, as assayed in a gel-shift assay of the truncated chrebp, was gradually inactivated with time by treatment with ampk | SIGNOR-176494 |
P23786 | Q86TM6 | 0 | ubiquitination | down-regulates quantity | 0.2 | Taken together, these data suggest that HRD1 selectively and specifically downregulates intracellular CPT2 levels.|These results demonstrate that HRD1 ubiquitinates CPT2, which is processed through Lys-48-linked ubiquitin chains. | SIGNOR-278723 |
P42574 | P49768 | 1 | cleavage | up-regulates activity | 0.454 | Remarkably, the caspases acting on PS1 could be subdivided in two groups. One group, containing caspase-8, -6 and -11, cleaved PS1 after residues ENDD329 and to a lesser extent after residues AQRD341. A second group consisting of caspase-3, -7 and -1 acted uniquely on AQRD341. Importantly, these two cleavage sites were... | SIGNOR-261756 |
Q92835 | P07948 | 0 | phosphorylation | up-regulates activity | 0.509 | In this line, Lyn has been demonstrated to tyrosine-phosphorylate and activate SHIP1, thereby constituting a negative feedback control of PI3K-mediated signals. | SIGNOR-279060 |
Q9HCM2 | Q13214 | 2 | binding | up-regulates activity | 0.65 | We provide evidence suggesting that, in endothelial cells and glioblastoma cells, plexin-A4 is a required component of both Sema3A and Sema3B receptor complexes and inhibition of its expression nullifies both Sema3A and Sema3B signaling. The specificity for Sema3A or Sema3B is determined by the presence of plexin-A1 in... | SIGNOR-261810 |
Q07812 | O43464 | 1 | relocalization | up-regulates | 0.313 | Bax and/or bak-mediated release of pro-apoptotic mediators including smac/diablo and omi | SIGNOR-88590 |
P30281 | Q9UKC9 | 2 | binding | down-regulates quantity by destabilization | 0.484 | Here, we show that a relatively new E3 ligase component belonging to the SCF (Skip-Cullin1-F-box protein) E3 ligase family, SCF (FBXL2) , impairs cell proliferation by mediating cyclin D3 polyubiquitination and degradation. | SIGNOR-271887 |
O14965 | Q96EZ8 | 1 | phosphorylation | up-regulates activity | 0.316 | We conclude that Aurora-A phosphorylates MCRS1 on Ser35/36 specifically during mitosis. | SIGNOR-278232 |
O94856 | Q01484 | 1 | relocalization | up-regulates quantity | 0.694 | Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with... | SIGNOR-266716 |
Q9Y5G8 | Q9Y5H9 | 2 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265695 |
P67809 | Q7Z6E9 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.317 | RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1 | SIGNOR-271773 |
Q14247 | P11362 | 0 | phosphorylation | down-regulates | 0.313 | Cortactin, which is an actin-binding protein that also plays a role in actin cytoskeleton dynamics (45), was phosphorylated on tyr-446 in our assay (by fgfr1).Phosphorylation of these residues attenuates the f-actin cross-linking activity | SIGNOR-98618 |
P61077 | Q8NEG5 | 2 | binding | up-regulates activity | 0.331 | MEX can act as an E3, Ub (ubiquitin) ligase, through the E2, Ub-conjugating enzymes UbcH5a, UbcH5c or UbcH6. A region of MEX that contains the RING fingers and the ZZ zinc finger was required for interaction with UbcH5a and MEX self-association, whereas the SWIM domain was critical for MEX ubiquitination. The expressio... | SIGNOR-271557 |
P17612 | Q9P0L9 | 1 | phosphorylation | up-regulates activity | 0.2 | PKD2L1 channel activation by PKA phosphorylation. In this study, we observed the activity of PKD2L1 channel increased by the downstream cascades of β2AR and found the clustered phosphorylation sites, Ser-682, Ser-685, and Ser-686 that are significant in the channel regulation by phosphorylation. | SIGNOR-273562 |
P55212 | P49768 | 1 | cleavage | up-regulates activity | 0.372 | Remarkably, the caspases acting on PS1 could be subdivided in two groups. One group, containing caspase-8, -6 and -11, cleaved PS1 after residues ENDD329 and to a lesser extent after residues AQRD341. A second group consisting of caspase-3, -7 and -1 acted uniquely on AQRD341. Importantly, these two cleavage sites were... | SIGNOR-261753 |
P35222 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.269 | Moreover, protein kinase Cδ, which directly phosphorylates β-catenin at Ser715, is required for the TRIM33–β-catenin interaction. | Phosphorylation of β-catenin Ser715 is critical for TRIM33-induced β-catenin degradation | SIGNOR-260897 |
Q14344 | P43657 | 2 | binding | up-regulates activity | 0.353 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257347 |
Q13492 | P53675 | 2 | binding | up-regulates | 0.729 | Calm interacts with the clathrin heavy chain through its c-terminal third and with phophoinositides through its ap180 n-terminal homology (anth) domain, promoting assembly of clathrin triskelia into clathrin cagesin vitro | SIGNOR-144733 |
P53778 | Q12888 | 1 | phosphorylation | down-regulates activity | 0.2 | Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif.|Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks |phosphorylation of T1609 is likely to be mediated by p38 MAPK | SIGNOR-264448 |
P45985 | P31749 | 0 | phosphorylation | down-regulates | 0.594 | Akt phosphorylated sek1 on serine 78. | SIGNOR-236494 |
O60610 | O14757 | 0 | phosphorylation | down-regulates activity | 0.2 | Chk1 Phosphorylates Drf1 for beta-Trcp-Dependent Degradation.|From this we conclude that Chk1 inhibits Drf1, but not the other three limiting factors at the MBT. | SIGNOR-279026 |
P06702 | O00206 | 2 | binding | up-regulates activity | 0.546 | RAGE and TLR4 are well-characterized S100A8 and S100A9 receptors and expressed in AML cells. S100A9 binds to TLR4 and induces signaling pathways,promoting leukemic cell differentiation and proliferation arrest. Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the a... | SIGNOR-261918 |
Q9HB09 | P49841 | 0 | phosphorylation | up-regulates | 0.338 | Gsk3b phosphorylates bcl2l12 at s156. Ectopic expression of gfp-fused bcl2l12 or bcl2l12a in u87mg cells leads to repression of apoptotic markers and protects against staurosporine (sts) insults, indicating an antiapoptotic role for both bcl2l12 and bcl2l12a. In contrast, no anti-apoptotic ability was seen in bcl2l12(s... | SIGNOR-195512 |
P11168 | P52945 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.522 | In conclusion, Pdx1 confers the expression of pancreatic β-cell-specific genes, such as genes encoding insulin, islet amyloid polypeptide, Glut2, and Nkx6.1. | SIGNOR-255540 |
P17612 | P35240 | 1 | phosphorylation | up-regulates | 0.405 | Merlin contains a c-terminal serine 518, which is phosphorylated both by p21-activated kinase (pak) and protein kinase a (pka) (shaw et al., 2001;kissil et al., 2002;xiao et al., 2002;alfthan et al., 2004). Phosphorylation at this site is predicted to result in a more open conformation incapable of inhibiting cell grow... | SIGNOR-159840 |
Q02535 | Q14289 | 0 | phosphorylation | up-regulates quantity | 0.2 | Taken together these findings demonstrated that Pyk2 mediates the expression of ID3 protein.|Together these findings from the combined MS+MS/MS data confirm that Flag tagged ID3 is phosphorylated by active recombinant Pyk2 kinase; and support the phospho-Tyr band that was detected at the corresponding MW ~ 13 kDA for F... | SIGNOR-278496 |
Q02156 | O60716 | 1 | phosphorylation | down-regulates | 0.2 | We find that ctnnd1/p120ctn phosphorylation at serine 268 (p-s268) occurs in a strictly pkc_-dependent manner,serine/threonine phosphorylation of p120-ctn has been reported to affect the integrity of ajs [12], [24] and [25]. Xia et al. (2003) reported that several residues (ser122, ser252, ser268, ser288, thr310, ser31... | SIGNOR-201600 |
P41146 | O95837 | 2 | binding | up-regulates activity | 0.353 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257209 |
P46531 | Q92993 | 0 | acetylation | down-regulates | 0.414 | This result implies that the residues k2019, k2039, k2044, and k2068 of notch1-ic are the major targets of the acetyltransferase activity of tip60. | SIGNOR-156923 |
Q9BXM7 | Q9Y2N7 | 1 | phosphorylation | down-regulates activity | 0.347 | Here we show that IPAS is a key molecule involved in neuronal cell death in Parkinson's disease (PD). IPAS was ubiquitinated by Parkin for proteasomal degradation following carbonyl cyanide m-chlorophenyl hydrazone treatment. Phosphorylation of IPAS at Thr12 by PTEN-induced putative kinase 1 (PINK1) was required for ub... | SIGNOR-263090 |
Q70Z35 | P60484 | 2 | binding | down-regulates activity | 0.62 | Here, we report that P-REX2 interacts with PTEN via two interfaces. In summary, P-REX2 docks to the PDZ-BD of PTEN through its C-terminal domain, reads the phosphorylation state of the PTEN tail via the DH domain, and inhibits PTEN activity by unleashing the PH domain | SIGNOR-259189 |
P35568 | P29376 | 0 | phosphorylation | up-regulates | 0.314 | Recently, we demonstrated that ltk utilizes shc and irs-1 as two major substrates and while both equally activate the ras pathway, only irs-1 suppresses apoptosis of hematopoietic cells. | SIGNOR-49531 |
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