IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P16220 | Q13315 | 0 | phosphorylation | down-regulates | 0.522 | Individual ala substitutions at thr-100, ser-111, or ser-121 inhibited atm-catalyzed phosphate incorporationatm phosphorylated creb in vitro and in vivo in response to ionizing radiation (ir) and h(2)o(2) on a stress-inducible domain. Ir-induced phosphorylation of creb correlated with a decrease in creb transactivation... | SIGNOR-124051 |
Q13153 | P62714 | 0 | dephosphorylation | down-regulates activity | 0.2 | Both sites were dephosphorylated with the same kinetics; the anti-Ser(P)198 antibody was subsequently used as it exhibited lower background staining. Direct comparison of PP2Cα with purified PP1 and PP2A lead us to conclude that at the same molar ratio PP2Cα was the most efficient in dephosphorylating PAK1 (Fig. 1D). I... | SIGNOR-248600 |
Q9H2X6 | P00519 | 0 | phosphorylation | up-regulates activity | 0.403 | The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage | SIGNOR-260936 |
P04899 | O95379 | 2 | binding | up-regulates activity | 0.2 | TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation | SIGNOR-256492 |
Q13330 | O75364 | 2 | binding | up-regulates activity | 0.325 | we found that the MTA1/DJ1 complex is required for optimum stimulation of the TH expression by paired like homeodomain transcription factor (Pitx3) homeodomain transcription factor and that the MTA1/DJ1 complex is recruited to the TH gene chromatin via the direct interaction of MTA1 with Pitx3. | SIGNOR-239770 |
Q9UKB1 | O14920 | 2 | binding | down-regulates quantity by destabilization | 0.443 | We identified a human F-box/WD40 repeats protein (HOS), which is homologous to Slimb/h betaTrCP. Being a part of SCF complex with Skp1 and Cullin1, HOS specifically interacted with the phosphorylated IkappaB and beta-catenin, targeting these proteins for proteasome-dependent degradation in vivo. | SIGNOR-272544 |
P23528 | P12931 | 0 | phosphorylation | down-regulates | 0.553 | Tyrosine phosphorylation of cofilin at y68 by v-src leads to its degradation through ubiquitin-proteasome pathway | SIGNOR-188352 |
P27986 | Q9H0K1 | 0 | phosphorylation | up-regulates activity | 0.322 | The Regulatory Subunit of PI3K Is a Direct Catalytic Target of SIK2. These data confirm that p85α is a direct catalytic substrate of SIK2 and that SIK2 S154 phosphorylation significantly increases the activity of the PI3K/AKT pathway in ovarian cancer cells. | SIGNOR-277269 |
O95425 | P53350 | 0 | phosphorylation | up-regulates activity | 0.2 | PLK1 phosphorylates Ser238 of SVIL, which can promote the localization of SVIL to the central spindle and association with PRC1. Expression of a PLK1 phosphorylation site mutant, S238A-SVIL, inhibited myosin II activation at the equatorial cortex and induced aberrant furrowing. | SIGNOR-273729 |
P05231 | Q12968 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.283 | The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway has been found to play a role in regulating growth and differentiation in several cell types. However, the functional significance of NFAT in the vasculature is largely unclear. Here we show that NFATc1, NFATc3, and NFATc4 are expressed in hum... | SIGNOR-251732 |
Q13464 | P26038 | 1 | phosphorylation | up-regulates activity | 0.688 | Rho-associated kinase (Rho-kinase), which is activated by the small GTPase Rho, phosphorylates moesin at Thr558 in vitro. Here, using a site- and phosphorylation state-specific antibody, we found that the expression of dominant active RhoA in COS7 cells induced moesin phosphorylation and the formation of microvilli-lik... | SIGNOR-249014 |
Q9HBW1 | P78352 | 2 | binding | up-regulates activity | 0.424 | A possible function for the NGL–PSD-95 interaction is to couple trans-synaptic adhesion events to the recruitment of PSD-95 and other PSD-95-associated postsynaptic proteins. PSD-95 and liprin-α may be key synaptic scaffolding proteins that couple trans-synaptic adhesions to the assembly of synaptic proteins/vesicles | SIGNOR-264051 |
Q12888 | Q8IYW5 | 0 | ubiquitination | up-regulates quantity | 0.822 | E3 ligase RNF168-mediated 53BP1 ubiquitination through activated the mechanistic target of rapamycin (mTOR)-ribosomal S6 kinase (S6K) signaling and increased 53BP1 protein stability in response to IR|We further found that overexpression of RNF168 enhanced 53BP1 ubiquitination inhibited by G0S2 overexpression in U87 and... | SIGNOR-278777 |
Q9BX84 | Q9BX84 | 2 | phosphorylation | down-regulates activity | 0.2 | Autophosphorylation of Threonine1851 in the Kinase Domain Is Essential for the Inhibitory Effect of RACK1 | SIGNOR-260922 |
P62993 | P29353 | 2 | binding | up-regulates | 0.965 | TGF-beta-induced ShcA phosphorylation induces ShcA association with Grb2 and Sos, thereby initiating the well-characterised pathway linking receptor tyrosine kinases with Erk MAP kinases. | SIGNOR-236366 |
O95471 | P09758 | 2 | binding | up-regulates quantity | 0.394 | In summary, our findings provide evidence that Trop-2 is phosphorylated at Ser-322 by PKCα/δ and that this phosphorylation enhances cell motility and decreases claudin-7 localization to cellular borders. | SIGNOR-273822 |
P39019 | P11309 | 0 | phosphorylation | up-regulates | 0.438 | The pim-1/rps19 interaction was demonstrated both in vitro and in living cells and led to phosphorylation of rps19 in an in vitro kinase assay. | SIGNOR-141411 |
P22392 | P22392 | 2 | phosphorylation | up-regulates activity | 0.2 | Using site-directed mutagenesis of the cDNA encoding NM23-H2, we have created a mutant substituting for the amino acid histidine 118, the presumed site of phosphorylation in the formation of the phosphoenzyme intermediate, the nonphosphorylatable amino acid phenylalanine. The H118F mutant protein is shown to be catalyt... | SIGNOR-250304 |
Q9H2P0 | P49711 | 1 | relocalization | down-regulates activity | 0.206 | These results argue against the simultaneous binding of CTCF and ADNP to the same genomic loci. Instead, they support a model in which ADNP counteracts stable association of CTCF with DNA at over 15,000 binding sites in the mouse genome. | SIGNOR-266755 |
P19544 | P15514 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.396 | The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin | SIGNOR-251745 |
Q9BV73 | Q68D86 | 1 | relocalization | up-regulates activity | 0.2 | CCDC102B is recruited to the centrosome by C-Nap1 (also known as CEP250) and interacts with the centrosome linker components rootletin and LRRC45. CCDC102B decorates and facilitates the formation of rootletin filaments. Furthermore, CCDC102B is phosphorylated by Nek2A (an isoform encoded by NEK2) and is disassociated f... | SIGNOR-275625 |
P24941 | Q06609 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.595 | Phosphorylation of the BRCA2 C-terminal RAD51 binding site by CDK2 promotes RAD51 filament disassembly, leading to nucleolitic cleavage of newly synthesized DNA and compromised fork integrity. | SIGNOR-280213 |
Q9H0H5 | Q96GD4 | 0 | phosphorylation | up-regulates activity | 0.78 | It was found that the 5A fragment in which five Ser/Thr residues were substituted with Ala (S144A/T145A/S185A/T186A/S187A) fully prevented phosphorylation (Fig. 5B), confirming that Aurora B primarily phosphorylates five Ser/Thr residues in the basic region of MgcRacGAP. | the strong phosphorylation of the basic region... | SIGNOR-250590 |
O15105 | Q96J02 | 0 | ubiquitination | down-regulates | 0.506 | We identified atrophin 1-interacting protein 4 (aip4) as an e3 ubiquitin ligase that specifically targets smad7 for ubiquitin-dependent degradation without affecting the turnover of the activated tbetari. Surprisingly, we found that despite the ability to degrade smad7, aip4 can inhibit tgf-beta signaling, presumably b... | SIGNOR-137951 |
P17252 | P49841 | 1 | phosphorylation | down-regulates | 0.357 | Gsk3 is different from most kinases in that it is constitutively partially active and the most common regulatory mechanism is inhibition by phosphorylation of ser21 in gsk3_ or ser9 in gsk3_. This inhibitory phosphorylation can be mediated by several kinases, such as akt/protein kinase b (pkb), protein kinase c (pkc) a... | SIGNOR-188581 |
Q9Y243 | O15530 | 0 | phosphorylation | up-regulates | 0.651 | The activation of pkbbeta and pkbgamma by pdk1 was accompanied by the phosphorylation of the residues equivalent to thr308 in pkbalpha, namely thr309 (pkbbeta) and thr305 (pkbgamma) | SIGNOR-55937 |
P31751 | Q9UBI6 | 2 | binding | up-regulates | 0.412 | We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein) coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the... | SIGNOR-141792 |
Q99759 | P46734 | 1 | phosphorylation | up-regulates activity | 0.558 | These data indicate that mkk3 is preferentially activated by mekk3, whereas mkk4 is activated both by mekk2 and mekk3. | SIGNOR-48625 |
P03372 | P26045 | 0 | dephosphorylation | up-regulates activity | 0.2 | Our recent studies further demonstrated that PTPH1 dephosphorylates estrogen receptor at Y537, increases estrogen receptor stability and nuclear accumulation, and enhances breast cancer sensitivity to anti-estrogens [ ]. | SIGNOR-277127 |
P50570 | P12931 | 0 | phosphorylation | down-regulates activity | 0.557 | We used cSrc-transformed NIH 3T3 fibroblasts to examine the effect of mutant Dyn2Y597. Similar to its effect in myotubes, Dyn2Y597F presented reduced enrichment at podosomes, whereas Dyn2Y597E clearly targeted podosome rosettes (Figures S9B and S9C). Moreover, Dyn2Y597F significantly reduced the podosome area, ECM degr... | SIGNOR-277539 |
P63104 | P45984 | 0 | phosphorylation | down-regulates | 0.2 | Jnk phosphorylates 14-3-3zetaat ser-184 and 14-3-3sigmaat ser-188 | SIGNOR-124031 |
P35568 | Q13627 | 0 | phosphorylation | up-regulates quantity | 0.2 | DYRK1A interacts with IRS-1 and phosphorylates IRS-1 at Ser-312 and Ser-616.|We found that DYRK1A overexpression up-regulated IRS-1 expression by slowing the turnover of IRS-1 protein. | SIGNOR-279521 |
Q5MJ70 | O94901 | 2 | binding | up-regulates activity | 0.247 | In this study, we found that SUN1 not only interacted with TERB1 but also interacted with MAJIN, and the interaction of SUN1 with MAJIN is stronger than TERB1. We also found that SUN1 interacted with SPDYA, an activator of CDK2. | Taken together, we speculate that speedy A is likely capable of interacting with both tel... | SIGNOR-263301 |
Q6DJT9 | Q8WUI4 | 0 | deacetylation | down-regulates | 0.255 | Plag1 and plagl2 are also regulated by acetylation. They are acetylated and activated by p300 and deacetylated and repressed by hdac7. | SIGNOR-140950 |
Q13237 | P42261 | 1 | phosphorylation | up-regulates activity | 0.44 | In cultured hippocampal neurons, activation of cGKII induces an accumulation of GluR1 on the cellular plasma membrane at extrasynaptic sites, and blockage of cGKII activity prevents the surface increase of GluR1, and also the increase in mEPSC frequency and amplitude, that follows a chemical form of LTP (chemLTP).|In t... | SIGNOR-278427 |
P19474 | Q92985 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.677 | Furthermore, this Ro52 mediated degradation of IRF7 was inhibited in the presence of MG132, a proteasome inhibitor, indicating that IRF7 is targeted to the proteasome for degradation (XREF_FIG).|Ro52 ubiquitinates IRF7 in a dose dependent manner. | SIGNOR-278619 |
P60484 | O75365 | 0 | dephosphorylation | down-regulates quantity by destabilization | 0.296 | As expected, PRL3 clearly reduced PTEN phosphorylation at the tyrosine residue and PTEN protein in PRL3 overexpressing LO2 and HepG2 cell lines, with no significant changes in PRL3 (C104S) mutant cells.|PRL3 down-regulates PTEN expression, a negative regulator of the Akt pathway.11 Phosphorylation of PTEN at Tyr336 is ... | SIGNOR-277010 |
P05412 | Q9UBF6 | 0 | ubiquitination | down-regulates activity | 0.324 | SAG (Sensitive to Apoptosis Gene), also known as RBX2 (RING box protein 2), ROC2 (Regulator of Cullins 2), or RNF7 (RING Finger Protein 7), was originally cloned in our laboratory as a redox inducible antioxidant protein and later characterized as the second member of the RBX/ROC RING component of the SCF (SKP1-CUL-F-b... | SIGNOR-271452 |
P41743 | P15311 | 1 | phosphorylation | up-regulates | 0.342 | Pkciota phosphorylated ezrin on t567 in vitro, and in sf9 cells that do not activate human ezrin. we conclude that, although other molecular mechanisms contribute to ezrin activation, apically localized phosphorylation by pkciota is essential for the activation and normal distribution of ezrin at the early stages of i... | SIGNOR-160855 |
P06239 | Q9Y2R2 | 0 | dephosphorylation | down-regulates activity | 0.751 | In vitro experiments with purified recombinant proteins demonstrated that PTPN22-D195A/C227S interacted directly with activated Lck, Zap70, and TCRzeta, confirming the initial substrate trap results. Native PTPN22 dephosphorylated Lck and Zap70 at their activating tyrosine residues Tyr-394 and Tyr-493, respectively, bu... | SIGNOR-248836 |
P00813 | P30542 | 2 | binding | up-regulates activity | 0.571 | The results show that human ADA, apart from reducing the adenosine concentration and thus preventing A(1)R desensitization, binds to A(1)R behaving as an allosteric effector that markedly enhances agonist affinity and increases receptor functionality. | SIGNOR-269105 |
Q16584 | Q02750 | 1 | phosphorylation | up-regulates activity | 0.335 | Here we report that MLK3 can phosphorylate and activate MEK-1 directly in vitro and also can induce MEK phosphorylation on its activation sites in vivo in COS-7 cells. | SIGNOR-280019 |
Q7LBC6 | Q07869 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | We show that Jhdm2a expression is induced by beta-adrenergic stimulation, and that Jhdm2a directly regulates peroxisome proliferator-activated receptor alpha (Ppara) and Ucp1 expression. | SIGNOR-266637 |
Q9C0D5 | P78352 | 2 | binding | up-regulates activity | 0.596 | In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. our results indicate that TANC-dependent spine/synapse maintenance requires TANC binding to PSD-95, which promotes synaptic localization of TANC proteins. Thus, it is likely that interact... | SIGNOR-266894 |
Q9UBP6 | Q15418 | 0 | phosphorylation | down-regulates | 0.324 | Pkb and ribosomal s6 kinase (rsk) both phosphorylated mettl1 at ser27 in vitro. | SIGNOR-135948 |
Q9H3R0 | P84243 | 1 | demethylation | down-regulates activity | 0.2 | As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, an... | SIGNOR-263869 |
O95163 | P42345 | 0 | phosphorylation | up-regulates activity | 0.2 | Human ELP1 S1174 phosphorylation was triggered by insulin treatment, as shown by the specific phosphorylated (p)ELP1 (S1174) antibody, and addition of a phosphorylation-mutant variant of the ELP1 protein (ELP1(S1174A)) to ELP1-depleted BRAFV600E melanoma cells failed to rescue cell survival |In line with these findings... | SIGNOR-275541 |
Q96BH1 | Q969F2 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.451 | Here, we show that Naked2 is a short-lived protein with a half-life of 60 min caused by its rapid ubiquitin-mediated proteasomal degradation. Overexpression of TGF-alpha stabilizes Naked2 protein in an EGF receptor (EGFR)-independent manner; a physical interaction between the cytoplasmic tail of TGF-alpha and Naked2 is... | SIGNOR-271738 |
Q15208 | Q13043 | 0 | phosphorylation | up-regulates activity | 0.332 | Although MST1, MST2, and MST3 potently activated NDR1 in vitro, MST4 had only a minor effect.|Indeed, NDR1 phosphorylated at Thr444 by MST1 displayed greatly (7-fold) enhanced protein kinase activity. | SIGNOR-279641 |
Q9HAU4 | P37173 | 1 | ubiquitination | down-regulates activity | 0.595 | Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps. | SIGNOR-195681 |
P42263 | Q9BYB0 | 2 | binding | up-regulates quantity | 0.2 | SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK prot... | SIGNOR-264603 |
P15692 | P15172 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.391 | We further demonstrate that the myogenic transcription factor, MyoD, and its heterodimeric binding proteins E12 and E47, up-regulate the expression of endogenous VEGF through direct interaction with the VEGF promoter. | SIGNOR-257598 |
P15172 | P17661 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.24 | MyoD and HDAC2 repress myogenic late genes at early times of differentiation.A time course of Ckm, Des and Acta1 gene expression demonstrated that these genes were prematurely expressed when differentiation was driven by myogenin and Mef2D1b (Figure _(Figure6A).6A). Since MyoD is not expressed under these conditions, i... | SIGNOR-241762 |
P17612 | P46019 | 1 | phosphorylation | down-regulates activity | 0.325 | Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme. | SIGNOR-267410 |
Q96GD4 | O95239 | 1 | phosphorylation | up-regulates activity | 0.517 | Using in vitro kinase assays, we found that active AMPK and Aurora B phosphorylated KIF4A at Ser801 and Thr799 respectively in a time-dependent manner (Figure 5D). KIF4A is phosphoregulated by AMPK and Aurora B. Although AMPK phosphorylation increased the ATPase activity of KIF4A, Aurora B phosphorylation resulted in ... | SIGNOR-265992 |
Q9GZV5 | Q86U44 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Here we find that METTL3 promotes translation of certain mRNAs including epidermal growth factor receptor (EGFR) and the Hippo pathway effector TAZ in human cancer cells. | SIGNOR-265955 |
Q96P44 | Q16832 | 2 | binding | up-regulates activity | 0.2 | The Discoidin Domain Receptors (DDRs) constitute a unique set of receptor tyrosine kinases that signal in response to collagen.|Consistent with this view128, we showed that ectopic expression of DDR1b or DDR2 in HT1080 cells elicited a potent growth inhibitory effect only when the cells were cultured on 2D or 3D COL1 m... | SIGNOR-272343 |
P35222 | P04626 | 0 | phosphorylation | down-regulates activity | 0.766 | Second, ErbB2 phosphorylates \u03b2-catenin at Tyr 654, leading to dissociation of the E-cadherin-\u03b2-catenin membrane complex and increased signaling to Wnt target genes such as cyclin D1 ( ). | SIGNOR-279041 |
P19525 | Q13217 | 2 | binding | down-regulates activity | 0.635 | The protein p58IPK {also known asDnaJ3C [DnaJ heat-shock protein (hsp) 40 homologue, subfamily C, member 3]} is known to inhibit the eIF2 kinases PKR (dsRNA-dependent protein kinase/eIF2 kinase 2) and PERK | SIGNOR-246207 |
Q9Y5H9 | Q9Y5H2 | 2 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265690 |
P24941 | P30305 | 0 | dephosphorylation | up-regulates activity | 0.767 | CDC25B is also able to dephosphorylate and activate CDK2-Cyclin A and CDK2-Cyclin E complexes [ xref \u2013 xref ]. | SIGNOR-277140 |
Q9Y2U5 | Q13163 | 1 | phosphorylation | up-regulates | 0.762 | Mekk2 and mekk3 are mapk kinase kinases that bind, phosphorylate and activate mek5. | SIGNOR-104634 |
P11387 | P17252 | 0 | phosphorylation | up-regulates activity | 0.2 | In vitro kinase assays demonstrated that Ser(10) can be phosphorylated by casein kinase II, Ser(21) can be phosphorylated by protein kinase Calpha, and Ser(112) and Ser(394) can be phosphorylated by Cdk1.Collectively these results indicate that topo I is phosphorylated during mitosis at multiple sites, one of which enh... | SIGNOR-276154 |
P10275 | Q5VWQ8 | 2 | binding | down-regulates activity | 0.328 | DAB2IP acts as a scaffold protein for PP2A to suppress DHT-elicited S81 phosphorylation of the AR, preventing its nuclear translocation and binding to androgen response elements. In addition, DAB2IP can compete with the AR for binding to c-Src, thus blocking the non-genomic AR pathway | SIGNOR-254758 |
P19784 | Q9UNN4 | 1 | phosphorylation | up-regulates activity | 0.414 | ALF was able to stabilize the binding of TBP to DNA, but it could not stabilize TBP mutants A184E, N189E, E191R, and R205E nor could it facilitate binding of the TBP-like factor TRF2/TLF to a consensus TATA element. However, phosphorylation of ALF with casein kinase II resulted in the partial restoration of complex for... | SIGNOR-250993 |
P42345 | P15918 | 0 | relocalization | up-regulates | 0.256 | Rag gtpases, together with a multi-protein complex called ragulator, mediate amino acid-mediated mtor recruitment to the lysosome surface where mtor becomes activated. | SIGNOR-198242 |
P25105 | O95837 | 2 | binding | up-regulates activity | 0.413 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257436 |
O94972 | O94972 | 2 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | In this paper, we present data showing that TRIM37, a member of the TRIM subfamily of RING finger proteins, is autoubiquitinated in a RING domain-dependent manner. However, we feel tempted to speculate that the most likely mechanism, in which TRIM37-mediated ubiquitination could be involved, is proteasomal degradation... | SIGNOR-271503 |
P24530 | O95837 | 2 | binding | up-regulates activity | 0.437 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257428 |
Q9NQU5 | P08134 | 1 | phosphorylation | down-regulates activity | 0.2 | It is possible that Pak6 may directly phosphorylate RhoC to regulate its activity.|Nevertheless, our results clearly show that the kinase activity of Pak6 is required to inhibit RhoC induced cell contraction. | SIGNOR-280059 |
Q05086 | Q05086 | 2 | ubiquitination | down-regulates quantity by destabilization | 0.2 | We show here that HPV16 E6 promotes the ubiquitination and degradation of E6AP itself. | SIGNOR-271398 |
P24941 | O75533 | 1 | phosphorylation | up-regulates | 0.346 | To map the set of phosphorylation sites in sap155-(223-322) that determine its interaction with nipp1, we have identified phosphorylation sites of cyclin e-cdk2 by the sequencing of proteolytically derived phosphopeptide). Three phosphorylation sites were identified as thr244, thr248, and thr313 | SIGNOR-90434 |
P12931 | P17813 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.385 | We identified epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as Src-activators that induce endoglin turnover following (612)YIY(614) phosphorylation. | SIGNOR-276654 |
Q96T88 | Q5UIP0 | 1 | polyubiquitination | down-regulates activity | 0.2 | UHRF1 mediates K63-linked polyubiquitination of RIF1, and results in its dissociation from 53BP1 and DSBs thereby facilitating HR initiation. | SIGNOR-277193 |
P04234 | P06239 | 0 | phosphorylation | up-regulates activity | 0.571 | Last, we demonstrate directly that members of the CD3 complex, including the gamma, delta, and epsilon chains, as well as a putative zeta subunit, can be phosphorylated at tyrosine residues by the CD4/CD8.p56lck complex. | SIGNOR-259929 |
P53350 | P67809 | 1 | phosphorylation | up-regulates quantity | 0.253 | Here we identify that PLK1 inhibition can induce apoptosis and DNA damage of GSCs, we have also delineat the possible underlying molecular mechanisms: PLK1 interacts with YBX1 and directly phosphorylates serine 174 and serine 176 of YBX1.|Inhibition of PLK1 reduces the phosphorylation level of YBX1, and decreased phosp... | SIGNOR-279255 |
P68431 | P83916 | 2 | binding | up-regulates activity | 0.2 | A core characteristic of heterochromatin is its association with heterochromatin protein 1 (HP1) proteins, a highly conserved family of chromosomal proteins that bind to di- and trimethylated H3K9 via a conserved N-terminal domain called the chromodomain (CD) HP1 proteins are a highly conserved family of eukaryotic pr... | SIGNOR-264493 |
P06493 | Q8TEM1 | 1 | phosphorylation | up-regulates activity | 0.549 | In vitro phosphorylation of GST fusion protein containing the carboxyl-terminal domain of gp210 by cyclin B-p34cdc2 protein kinase generates a phosphopeptide that comigrates with a mitosis-specific phosphopeptide. Ser1880 Is the Mitotic Phosphorylation Site of Gp210. | SIGNOR-262699 |
O75385 | P09467 | 1 | phosphorylation | down-regulates activity | 0.2 | Here, we demonstrate that, during deprivation of amino acid and growth factors, ULK1/2 directly phosphorylate key glycolytic enzymes including hexokinase (HK), phosphofructokinase 1 (PFK1), enolase 1 (ENO1), and the gluconeogenic enzyme fructose-1,6-bisphosphatase (FBP1).Phosphorylation of these enzymes leads to enhanc... | SIGNOR-274031 |
P50570 | O00159 | 2 | binding | up-regulates | 0.355 | Dynamin bind directly to the sh3 domain of myo1e / an intriguing possibility is that binding of dynamin and synaptojanin to myo1e tail may activate motor activity since it has been demonstrated that myo1e atpase activity is autoinhibited by its sh3 domain | SIGNOR-152910 |
Q9GZV5 | Q15561 | 2 | binding | up-regulates | 0.869 | When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. | SIGNOR-201459 |
P40763 | P52333 | 0 | phosphorylation | up-regulates | 0.792 | Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly ... | SIGNOR-256254 |
P12931 | Q96KG7 | 1 | phosphorylation | up-regulates activity | 0.378 | Our data suggest that c-Src augments the phosphorylation of MEGF10 and helps form a signaling complex.|These results indicate that overexpressed MEGF10 is phosphorylated by c-Src. | SIGNOR-279290 |
Q5H8A3 | Q9HB89 | 2 | binding | up-regulates | 0.729 | Here we identify a novel neuropeptide of 36 amino-acid residues in rat brain as an endogenous ligand for the orphan g protein-coupled receptor fm-4/tgr-1, which was identified to date as the neuromedin u (nmu) receptor, and designate this peptide 'neuromedin s (nms)' because it is specifically expressed in the suprachi... | SIGNOR-133074 |
P29275 | O95837 | 2 | binding | up-regulates activity | 0.275 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257414 |
P09601 | Q16236 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.679 | In both models, the inducer-modified and Nrf2-bound Keap1 is inactivated and, consequently, newly synthesized Nrf2 proteins bypass Keap1 and translocate into the nucleus, bind to the ARE and drive the expression of Nrf2 target genes such as NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HMOX1), glutamate-cy... | SIGNOR-256276 |
P51608 | P61278 | 1 | post transcriptional regulation | up-regulates quantity by expression | 0.297 | MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. | SIGNOR-264676 |
Q9BV40 | Q86YJ5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MARCH9, a member of the RING-CH family of transmembrane E3 ubiquitin ligases, down-regulates CD4, major histocompatibility complex-I (MHC), and ICAM-1 in lymphoid cells. To identify novel MARCH9 substrates, we used high throughput flow cytometry and quantitative mass spectrometry by stable isotope labeling by amino aci... | SIGNOR-271531 |
P37198 | P23258 | 2 | binding | up-regulates activity | 0.2 | Furthermore, we found interactions and co-localization with γ-tubulin and SAS-6. Our results also point to a potential role of Nup62 in targeting gamma-tubulin and SAS-6 to the centrioles. | SIGNOR-261257 |
Q9NPG1 | Q9H1J5 | 2 | binding | up-regulates | 0.621 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-131984 |
Q13535 | Q9UBU7 | 1 | phosphorylation | down-regulates | 0.657 | Dbf4/cdc7 (dbf4-dependent kinase (ddk)) is activated at the onset of s-phase, and its kinase activity is required for dna replication initiation from each origin. We identified novel atm/atr phosphorylation sites on dbf4 and showed that atm/atr-mediated phosphorylation of dbf4 is critical for the intra-s-phase checkpoi... | SIGNOR-177809 |
P28482 | P01106 | 1 | phosphorylation | up-regulates activity | 0.735 | Transactivation of gene expression by myc is inhibited by mutation at the phosphorylation sites thr-58 and ser-62. | SIGNOR-235700 |
Q16552 | Q96F46 | 2 | binding | up-regulates | 0.924 | Binding studies suggest that recombinant hil-17 binds to the hil-17r with low affinity. Monoclonal antibodies (mabs) generated against the hil-17r were able to block the il-17-induced production of cytokine from human foreskin fibroblast (hff) cells. | SIGNOR-53249 |
P68400 | Q01831 | 1 | phosphorylation | up-regulates activity | 0.2 | CK2 kinase mediates XPC phosphorylation at serine 94, and also promotes recruitment of ubiquitinated XPC to the chromatin after UVB irradiation. | SIGNOR-277389 |
P04035 | Q12772 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.492 | The processed SREBP2, designated nuclear SREBP2 (nSREBP2), then enters the nucleus as a homodimer, binds to the sterol regulatory element (SRE) sequence in the promoters of target genes, including HMGCR and SQLE (encoding squalene monooxygenase), and upregulates their transcription | SIGNOR-265161 |
Q13464 | O60237 | 1 | phosphorylation | down-regulates | 0.586 | Phosphorylation of ppp1r12b on threonine 646 by rho kinase inhibits the activity of the pp1c-ppp1r12b complex. | SIGNOR-198812 |
O00482 | Q15466 | 2 | binding | down-regulates | 0.563 | Modulation of human nuclear receptor lrh-1 activity by phospholipids and shpthe human nuclear receptor liver receptor homolog 1 (hlrh-1) plays an important role in the development of breast carcinomas. This orphan receptor is efficiently downregulated by the unusual co-repressor shp | SIGNOR-134202 |
P49327 | Q9H7Z6 | 0 | acetylation | down-regulates quantity by destabilization | 0.2 | Overexpression of Myc-KAT8 increased the acetylation level of endogenous FASN by 2.2-fold (Fig. 3C). In contrast, knockdown of KAT8 decreased endogenous FASN acetylation by as much as 55% | SIGNOR-267366 |
P41143 | P01213 | 0 | chemical activation | up-regulates activity | 0.667 | Accordingly, for the OTDP, the binding affinity and activity of a large number of opiate compounds have been tested at μ-, δ-, and κ-opiate receptors. Binding studies were originally conducted in guinea pig brain membranes, and subsequent studies have been carried out in CHO cells transfected with human receptors. Tabl... | SIGNOR-258415 |
P63096 | P21917 | 2 | binding | up-regulates activity | 0.463 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256703 |
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