IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q9Y259 | P17612 | 0 | phosphorylation | up-regulates activity | 0.253 | Choline kinase beta (CKbeta) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine. | This study provides evidence for CKβ phosphorylation by protein kinase A (PKA).|Phosphorylation sites were located on CKβ residues serine-39 and serine-40 as determined by mass spectrometry and site-directed mu... | SIGNOR-275629 |
P49815 | P54646 | 0 | phosphorylation | up-regulates | 0.577 | We have observed that ampk directly phosphorylates tsc2, and the ampk-dependent phosphorylation of tsc2 is critical for the coordination between cell growth and cellular energy levels. | SIGNOR-149388 |
P45984 | O43521 | 1 | phosphorylation | up-regulates activity | 0.637 | JNKs specifically phosphorylate BIMEL at Ser55, 65, and/or 73. several observations demonstrate that the phosphorylation of BIMEL is a physiologically important mechanism for enhancing its proapoptotic activity. | SIGNOR-250134 |
P10721 | P21583 | 2 | binding | up-regulates activity | 0.934 | The most relevant and still unique mast-cell growth factor is SCF, which is the ligand of KIT, a receptor with tyrosine-kinase activity that is expressed on the surface of all human and murine mast cells | SIGNOR-254946 |
P31749 | P54198 | 1 | phosphorylation | up-regulates activity | 0.2 | Consistently, HIRA phosphorylation was effectively decreased by Akt1 knockdown and was completely eliminated by the depletion of both Akt1 and Akt2, suggesting that HIRA is phosphorylated primarily by Akt1 and that Akt2 seemed to contribute to HIRA phosphorylation as a supplementary kinase in myoblasts (XREF_FIG).|In t... | SIGNOR-279584 |
Q9UKL3 | Q14790 | 2 | binding | up-regulates | 0.448 | The caspase-8-binding protein flice-associated huge protein (flash) would form a molecular complex with caspase-8, thereby presumably activating the mitochondrial apoptosis pathway by regulating caspase-8 activity. | SIGNOR-152473 |
P33981 | P38646 | 1 | phosphorylation | up-regulates | 0.2 | Mortalin binds to mps1, and is phosphorylated by mps1 on thr62 and ser65. The phosphorylated mortalin then super-activates mps1 in a feedback manner. Mps1-associated acceleration of centrosome duplication depends on the presence of mortalin and super-activation by the thr62/ser65 phosphorylated mortalin | SIGNOR-156185 |
P12931 | P45984 | 0 | phosphorylation | up-regulates activity | 0.355 | Activation of c-Src by JNK2 was accompanied by the phosphorylation of c-Src on threonine residue (s).|JNK2 directly phosphorylates c-Src and activates its auto phosphorylation. | SIGNOR-279221 |
O14920 | P08151 | 1 | phosphorylation | up-regulates activity | 0.356 | Active IKKbeta promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma.|Herein, we demonstrate that IKKbeta phosphorylates GLI1 in DLBCL. | SIGNOR-279194 |
Q9UPQ7 | O15146 | 1 | ubiquitination | down-regulates quantity | 0.543 | We have identified a PDZ domain containing RING finger 3 (PDZRN3) as a synapse-associated E3 ubiquitin ligase and have demonstrated that it regulates the surface expression of muscle-specific receptor tyrosine kinase (MuSK), the key organizer of postsynaptic development at the mammalian neuromuscular junction. PDZRN3 b... | SIGNOR-271664 |
Q9HCE7-2 | Q9H469 | 2 | binding | down-regulates quantity by destabilization | 0.56 | Here, we report that F-box and LRR domain-containing protein 15 (FBXL15), an F-box protein of the FBXL family, forms an Skp1-Cullin1-F-box protein-Roc1 (SCF)(FBXL15) ubiquitin ligase complex and targets Smurf1 for ubiquitination and proteasomal degradation. FBXL15, through its leucine-rich repeat domain, specifically... | SIGNOR-271909 |
P17612 | P32245 | 1 | phosphorylation | down-regulates activity | 0.308 | Activation of MC4R by agonist is associated with protein kinase A (PKA) and GRK phosphorylation of serine/threonine residues in the C-terminal tail of MC4R, followed by -arrestin and dynamin-dependent internalization of the receptor. Thr312 and Ser329/330 in the C-terminal tail of MC4R are potential sites for PKA | SIGNOR-250016 |
P18887 | O96017 | 0 | phosphorylation | up-regulates | 0.515 | Chk2 formed a complex with xrcc1, the ber scaffold protein, and phosphorylated xrcc1 in vivo and in vitro at thr(284). our results are consistent with the phosphorylation of xrcc1 by atm-chk2 facilitating recruitment of downstream ber proteins to the initial damage recognition/excision step to promote ber. | SIGNOR-181816 |
Q99623 | P15172 | 2 | binding | down-regulates | 0.365 | Phb2 interacts with both myod and mef2, and represses both myod- and mef2-dependent gene transcription. Furthermore, binding of phb2 to both myod and mef2 significantly decreases upon myogenic differentiation. | SIGNOR-235843 |
Q15465 | Q5VTY9 | 0 | palmitoylation | up-regulates | 0.683 | Our molecular analysis of knockout mice deficient in skn, the murine homolog of the drosophila ski gene, which catalyzes hh palmitoylation, and gene-targeted mice producting a non palmitoylated form of shh indicates that hh palmitoylation is essential for its activity as well as the generation of a protein gradient in ... | SIGNOR-124118 |
O15550 | P11308 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Our findings reveal a dual role for UTX in suppressing acute myeloid leukaemia via repression of oncogenic ETS and upregulation of tumor suppressive GATA programs. several ETS transcription factors, including Elf4, Etv6, Erg, Fli1, Ets2, Spi1 and Elk3 were upregulated immediately after Utx loss in the preleukaemic phas... | SIGNOR-260033 |
Q14493 | Q8IUE6 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265406 |
O15392 | P04637 | 2 | binding | down-regulates | 0.562 | This study identifies the anti-apoptotic survivin gene as a p53-repressed gene;notably, survivin repression by p53 is shown to be distinct from p53-dependent growth arrest. | SIGNOR-111971 |
Q86YC2 | Q13535 | 0 | phosphorylation | up-regulates activity | 0.307 | ATR promotes PALB2 accumulation at DNA damage sites.|In the context of PALB2 regulation, the phosphorylation of PALB2 by ATR plays a positive role in PALB2 recruitment. | SIGNOR-279588 |
Q06587 | Q13642 | 2 | binding | up-regulates | 0.357 | The polycombprotein ring1 interacts with the lim domains of kyot2 in yeast and mammalian cells. The interaction between kyot2 and ring1 was detected both in vitro and in vivo | SIGNOR-123150 |
P04083 | P05771 | 0 | phosphorylation | up-regulates | 0.2 | The authors identified several phosphorylated residues by a combination of peptide mapping and sequence analysis and showed that recombinant pp60c-src phosphorylates annexin a1 near its amino terminus, at tyrosine 21 (tyr21). Also polyoma virus middle t/pp60c-src complex, recombinant pp50v-abl, and the egf receptor/kin... | SIGNOR-202784 |
P46937 | Q9Y297 | 0 | ubiquitination | down-regulates | 0.544 | This cascade of phosphorylation allows the binding of scfbetatrcp that promotes the ubiquitination and degradation of yap. | SIGNOR-201138 |
P28482 | P20749 | 1 | phosphorylation | up-regulates activity | 0.474 | Here we show that Akt, Erk2, and IKK1/2 phosphorylate Bcl3. Phosphorylation of Ser33 by Akt induces switching of K48 ubiquitination to K63 ubiquitination and thus promotes nuclear localization and stabilization of Bcl3. Phosphorylation by Erk2 and IKK1/2 of Ser114 and Ser446 converts Bcl3 into a transcriptional coregul... | SIGNOR-277361 |
Q14653 | Q9BYM8 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.325 | Here we show that the E3 ubiquitin ligase RBCC protein interacting with PKC1 (RBCK1) catalyzes the ubiquitination and degradation of IRF3. We transfected 293 cells with expression plasmids for Flag-IRF3, HA-ubiquitin, and HA-RBCK1. Coimmunoprecipitation and western blot analysis indicated that RBCK1 significantly polyu... | SIGNOR-271737 |
Q00987 | Q92993 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.654 | Furthermore, we provide evidence that Mdm2, the ubiquitin ligase of the p53 tumour suppressor, interacts physically with Tip60 and induces its ubiquitylation and proteasome-dependent degradation. | SIGNOR-272613 |
P60953 | Q96N96 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.718 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260576 |
Q8NFZ3 | Q9HDB5 | 2 | binding | up-regulates activity | 0.2 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264168 |
Q9UQB3 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.327 | Cdk5 mediated delta-catenin phosphorylation regulates delta-catenin subcellular localization into two distinct pools : a cytoplasmic or intraneurite state as well as a pool that is localized to the membrane.|Cdk5 phosphorylates delta-catenin on serines 300 and 357. | SIGNOR-279323 |
Q13263 | O96017 | 0 | phosphorylation | down-regulates activity | 0.411 | In particular, Chk2 phosphorylates KAP1 on Ser473 decreasing the interaction between KAP1 and HP1 proteins: this post translational modification promotes HP1\u03b2 mobilization and the reorganization of chromatin structure favoring the repair of DNA breaks inside heterochromatin [ , ].|Of note, phosphorylation of S473 ... | SIGNOR-279730 |
P51681 | P35626 | 0 | phosphorylation | down-regulates activity | 0.2 | Serine residues at positions 336, 337, 342, and 349 represent GRK phosphorylation sites on CCR5. CCR5 phosphorylation and desensitization through a GRK-mediated mechanism | SIGNOR-251463 |
P41221 | Q9Y625 | 2 | binding | down-regulates activity | 0.374 | GPC6 binds to Wnt5a and inhibits its release from producing cells. Based on theseresults, and in our finding that GPC6 inhibits non-canonical Wnt signaling in the developing intestine,we tested the hypothesis that GPC6 binds to Wnt5aat the surface of the Wnt5a-producing mesenchymalcells and restrains its release from t... | SIGNOR-264030 |
P78536 | Q16539 | 0 | phosphorylation | up-regulates activity | 0.405 | We show that p38 MAP kinase, which is activated in response to inflammatory or stress signals, directly activates TACE, a membrane-associated metalloprotease that is also known as ADAM17 and effects shedding in response to growth factors and Erk MAP kinase activation. p38alpha MAP kinase interacts with the cytoplasmic ... | SIGNOR-163970 |
O60674 | P46527 | 1 | phosphorylation | down-regulates activity | 0.696 | JAK2 phosphorylates tyrosine residue 88 (Y88) of p27(Kip1). | SIGNOR-278260 |
P42224 | P23470 | 0 | dephosphorylation | up-regulates activity | 0.2 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254727 |
P40763 | Q14526 | 2 | binding | down-regulates quantity by repression | 0.367 | HIC1 interacts with the DNA binding domain of STAT3 and suppresses the binding of STAT3 to its target gene promoters. HIC1 C-terminal domain binds to STAT3. HIC1 mutant defective in STAT3 interaction reduced its repressive effect on STAT3 DNA binding activity, the reporter activity and gene expression of the VEGF and c... | SIGNOR-254246 |
Q9UBS0 | Q15633 | 1 | phosphorylation | up-regulates activity | 0.333 | We demonstrate that S6 kinases can phosphorylate the extended C-terminal domain of TRBP and interact with TRBP in situ in primary cells. TRBP serines 283/286 are essential for S6K-mediated TRBP phosphorylation, optimal expression of TRBP, and the S6K-TRBP interaction in human primary cells. | SIGNOR-274066 |
Q13315 | P38398 | 1 | phosphorylation | up-regulates | 0.819 | Results from this study indicate that the checkpoint protein kinase atm (mutated in ataxia telangiectasia) was required for phosphorylation of brca1 in response to ionizing radiation. Brca1 is phosphorylated at tyrosine residues in an atm-dependent, radiation-dependent manner. | SIGNOR-72075 |
Q6IMN6 | O75581 | 2 | binding | up-regulates | 0.358 | A cytoplasmic protein in vertebrates, referred to as caprin-2, binds to lrp6 and facilitates lrp6 phosphorylation by gsk3 | SIGNOR-187177 |
P35790 | Q14693 | 1 | phosphorylation | down-regulates activity | 0.273 | Because CKI is a constitutively active kinase and ubiquitously distributed in many cell types, high mTORC1 activity depending on nutritional status may be a physiological cue for Lipin1 degradation mediated by CKI and beta-TRCP.|Thus, we propose that mTORC1 may function as a priming kinase for CKI to promote the phosph... | SIGNOR-280228 |
P68400 | Q15019 | 1 | phosphorylation | down-regulates | 0.2 | Here we show that human septin 2 is phosphorylated in vivo at ser218 by casein kinase ii. Septin 2 binds and hydrolyses gtp. The purified protein has the capacity to polymerize into long filaments when loaded with gtp or gdp. Moreover, we show that the endogenous protein in hela cells, like that produced in insect cell... | SIGNOR-148010 |
P51955 | P04637 | 1 | phosphorylation | down-regulates | 0.318 | NEK2 Phosphorylates p53 at Ser315 and Reduces Its Stability.|These results are consistent with NEK2 inhibiting p53 transcriptional activation functions. | SIGNOR-278488 |
P41240 | P17612 | 0 | phosphorylation | up-regulates activity | 0.338 | Activation of the cooh-terminal src kinase (csk) by camp-dependent protein kinase inhibits signaling through the t cell receptor.Pka phosphorylates csk at s364 in vitro and in vivo leading to a two- to fourfold increase in csk activity that is necessary for camp-mediated inhibition of tcr-induced interleukin 2 secretio... | SIGNOR-105229 |
P06239 | Q9NP31 | 1 | phosphorylation | up-regulates activity | 0.578 | Here we mapped Lck phosphorylation and interaction sites on TSAd and evaluated their functional importance. The three C-terminal TSAd tyrosines Tyr(280), Tyr(290), and Tyr(305) were phosphorylated by Lck and functioned as docking sites for the Lck Src homology 2 (SH2) domain. Lck binds to TSAd prolines and phosphorylat... | SIGNOR-262888 |
Q9NRY4 | P61586 | 1 | gtpase-activating protein | down-regulates activity | 0.893 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260492 |
P49023 | Q05397 | 2 | binding | up-regulates activity | 0.914 | Focal adhesion kinase (FAK) is activated by growth factors and integrins during migration, and functions as a receptor-proximal regulator of cell motility. At contacts between cells and the extracellular matrix, FAK functions as an adaptor protein to recruit other focal contact proteins or their regulators, which affec... | SIGNOR-257732 |
O14672 | P26378 | 0 | post transcriptional regulation | up-regulates quantity | 0.2 | Neuronal ELAV (nELAV) proteins are RNA-binding proteins which play a physiological role in controlling gene expression in memory formation, and their alteration may contribute to cognitive impairment associated with neurodegenerative pathologies such as Alzheimer's disease (AD). The experiments show for the first time ... | SIGNOR-266865 |
P29350 | P43405 | 1 | dephosphorylation | down-regulates | 0.737 | We propose that shp1 can dephosphorylate sites in zap-70 and syk that are involved in coupling these kinases to downstream signaling cascades, including erk2 and elements of the il-2 gene. | SIGNOR-70234 |
Q92565 | P01116 | 1 | guanine nucleotide exchange factor | up-regulates | 0.436 | Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. | SIGNOR-183735 |
O43521 | P45984 | 0 | phosphorylation | up-regulates activity | 0.637 | JNKs specifically phosphorylate BIMEL at Ser55, 65, and/or 73. several observations demonstrate that the phosphorylation of BIMEL is a physiologically important mechanism for enhancing its proapoptotic activity. | SIGNOR-250134 |
Q15256 | P49023 | 1 | dephosphorylation | down-regulates activity | 0.2 | Here, we show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88 (Y88) in colorectal cancer (CRC) cells. We engineered CRC cells homozygous for a paxillin Y88F knock-in mutant and found that these cells exhibit significantly reduced cell mi... | SIGNOR-248720 |
P49840 | O15084 | 1 | phosphorylation | down-regulates activity | 0.2 | We provide evidence for a dual kinase-mediated regulation of the PITK holoenzyme whereby PITK phosphorylation at S1017 is catalyzed by calcium/calmodulin-dependent kinase II-delta (CaMKIIdelta), promoting the subsequent phosphorylation of S1013 by glycogen synthase kinase-3 (GSK3) in vitro.|the phosphorylation of PITK ... | SIGNOR-264792 |
Q92643 | Q96S52 | 2 | binding | up-regulates activity | 0.943 | To determine roles for PIG-S and PIG-T, we disrupted these genes in mouse F9 cells by homologous recombination. PIG-S and PIG-T knockout cells were defective in transfer of GPI to proteins, particularly in formation of the carbonyl intermediates. We also demonstrate that PIG-S and PIG-T form a protein complex with GAA1... | SIGNOR-261362 |
O96013 | Q15139 | 0 | phosphorylation | up-regulates activity | 0.252 | When PKD3 was knocked-down using isoform-specific shRNA (PKD3-shRNA), PAK4 activity (judged by its phosphorylation status at the activation loop using the pS474-PAK4 antibody) was decreased | SIGNOR-275930 |
P60953 | P12931 | 0 | phosphorylation | up-regulates | 0.695 | Epidermal growth factor-dependent regulation of cdc42 is mediated by the src tyrosine kinaseegf signaling through src appears to have dual regulatory effects on cdc42: 1). it leads to the activation of cdc42 as mediated by the vav2 guanine nucleotide exchange factor, and 2). it results in the phosphorylation of cdc42, ... | SIGNOR-118206 |
Q14289 | Q05397 | 1 | phosphorylation | up-regulates | 0.524 | Activated rock phosphorylates fak on ser732, which is essential for phosphorylation of tyr407 and for cell migration. We further show that pyk2 is activated by vegf-induced clustering of integrin v 3 and is responsible for the phosphorylation of tyr407. | SIGNOR-147070 |
P55211 | P98170 | 2 | binding | down-regulates quantity by destabilization | 0.922 | A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis | SIGNOR-105702 |
P42336 | P63215 | 2 | binding | up-regulates | 0.385 | Gbetagamma subunits released from gi can activate pi3k (phosphoinositide 3-kinase), and can be therefore implicated in smo-dependent activation of akt | SIGNOR-145125 |
P43686 | Q92630 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.284 | Through a kinome-wide screen, we have identified dual-specificity tyrosine-regulated kinase 2 (DYRK2) as the primary kinase that phosphorylates Rpt3-Thr25, leading to enhanced substrate translocation and degradation. | SIGNOR-275845 |
Q16539 | Q15717 | 1 | phosphorylation | up-regulates | 0.523 | P38 mapk phosphorylates the mrna binding protein hur on thr118, which results in cytoplasmic accumulation of hur and its enhanced binding to the p21cip1 mrna. | SIGNOR-186135 |
Q4VCS5 | Q9H0M0 | 0 | ubiquitination | up-regulates quantity by stabilization | 0.275 | Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, u... | SIGNOR-275847 |
Q8IZL8 | Q9NU22 | 2 | binding | up-regulates quantity by stabilization | 0.377 | MDN1 Is Physically and Functionally Associated with the Mammalian PELP1 Complex. To more specifically determine a function of mammalian MDN1 in the subnuclear distribution of PELP1-containing pre-60S-particles, we examined PELP1 localization in control cells or cells depleted from MDN1. Importantly, in the absence of M... | SIGNOR-261357 |
P29350 | P23458 | 1 | dephosphorylation | down-regulates | 0.646 | We find, for the first time, that shp-1 down-regulates the level of tyk2 kinase in h9 cells and of jak1 kinase in htb26 cells, by accelerating their degradation. | SIGNOR-119197 |
P49841 | P56693 | 1 | phosphorylation | down-regulates quantity | 0.406 | Besides, GSK3\u03b2 phosphorylates SOX10 at CPD domain and facilitates Fbxw7\u03b1-mediated SOX10 degradation.|Besides, GSK3beta phosphorylates SOX10 at CPD domain and facilitates Fbxw7alpha mediated SOX10 degradation. | SIGNOR-279617 |
Q9UM73 | Q9UM73 | 2 | phosphorylation | up-regulates activity | 0.2 | ALK SelectiVely Phosphorylates the First Tyrosine in Its A-Loop Peptide. | SIGNOR-250575 |
O95837 | P28222 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257207 |
P37840 | P48729 | 0 | phosphorylation | up-regulates | 0.371 | In vitro experiments and two-dimensional phosphopeptide mapping provided further evidence that serine 129 was phosphorylated by ck-1 and ck-2. Moreover, phosphorylation of serine 129 was reduced in vivo upon inhibition of ck-1 or ck-2. These data demonstrate that alpha-synuclein is constitutively phosphorylated within ... | SIGNOR-73799 |
Q96G91 | P38405 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256931 |
Q15303 | P35070 | 2 | binding | up-regulates | 0.723 | For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4 | SIGNOR-195347 |
Q9Y297 | O15534 | 1 | ubiquitination | down-regulates | 0.57 | We have found that per1 interacts with both _-trcp1 and _-trcp2 in a manner that depends on casein kinase 1 activity, and depletion of both _-trcp1 and _-trcp2 by rnai leads to dramatic stabilization of per1 | SIGNOR-137755 |
P08575 | P06241 | 1 | dephosphorylation | up-regulates activity | 0.73 | On the membrane SKAP55, via its phosphorylated Tyr-271, further binds the SH2 domain of Fyn to replace the low-affinity bound inhibitory site of the kinase. Consequently, CD45 may have transiently disassociated with the Tyr-232 residue of SKAP55 through dephosphorylation and simultaneously interacted with the released ... | SIGNOR-248352 |
P35222 | Q9ULB5 | 2 | binding | up-regulates activity | 0.568 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265869 |
P30550 | P38405 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256917 |
P00533 | P28482 | 0 | phosphorylation | down-regulates activity | 0.639 | A growth factor-stimulated protein kinase activity that phosphorylates the epidermal growth factor (EGF) receptor at Thr669 has been described Anion-exchange chromatography demonstrated that this protein kinase activity was accounted for by two enzymes. The first peak of activity eluted from the column corresponded to... | SIGNOR-20545 |
Q03113 | Q9HC97 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257204 |
P13288 | Q14653 | 1 | phosphorylation | down-regulates activity | 0.2 | BGLF4 kinase interacts physically with and phosphorylates IRF3, which is the initial activator of transcription in the innate immune response. BGLF4 suppresses IRF3-dependent transcriptional activation. Data here suggest that Ser123, Ser173, and Thr180 contribute additively to the BGLF4-mediated repression of the IRF3 ... | SIGNOR-266647 |
Q6PGQ7 | P49841 | 0 | phosphorylation | up-regulates | 0.258 | It suggests that gsk3_ activity is required for hbora-mediated mitotic entry through ser274 and ser278 phosphorylation | SIGNOR-201519 |
P41221 | Q01974 | 2 | binding | up-regulates | 0.775 | Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation|Evolutionarily conserved receptor tyrosine kinase–like orphan receptor-1 and -2 (ROR1/2) are considered distinct receptors for Wnt5a and are implicated in noncanonical Wnt signaling in organogenesis and cancer metastasis. | SIGNOR-199647 |
Q9BYT3 | Q5JQC9 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Differential phosphoproteomic analysis and in vitro kinase assay identified novel phosphorylation substrates of STK33, fibrous sheath components AKAP3 and AKAP4, whose expression levels decreased in testis after deletion of Stk33. | SIGNOR-272956 |
P63092 | Q03431 | 2 | binding | up-regulates activity | 0.506 | This calciotropic hormone exerts its actions via binding to the PTH/PTH-related peptide receptor (PTH1R), which couples to multiple heterotrimeric G proteins, including Gs and Gq/11. | SIGNOR-270551 |
P49761 | Q07955 | 1 | phosphorylation | up-regulates activity | 0.531 | In vitro, Clk/Sty efficiently phosphorylated the SR family member ASF/SF2 on serine residues located within its serine/arginine-rich region (the RS domain). Overexpression of the active Clk/Sty kinase caused a redistribution of SR proteins within the nucleus. These results suggest that Clk/Sty kinase directly regulates... | SIGNOR-273859 |
Q15172 | Q01484 | 0 | relocalization | up-regulates quantity | 0.282 | Ankyrin-B is targeted to the M-line via its interaction with the C-terminal domain of the large sarcomeric protein obscurin. Obscurin is targeted to the M-line via its N-terminal interactions with myomesin and titin. This population of ankyrin-B recruits B56α, a regulatory subunit of protein phosphatase 2A, to the M-li... | SIGNOR-266729 |
Q13207 | P23760 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.346 | We have recently found that a T-box gene family member, TBX2, is highly overexpressed in both ERMS and ARMS cells (Zhu et al, 2014). The regulation of TBX2 is uncharacterised in RMS cells, but is likely to link TBX2 expression to the known deregulation of signalling pathways in RMS. In melanoma cells, TBX2 is regulated... | SIGNOR-249596 |
Q92830 | P68431 | 1 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269602 |
P62136 | P42575 | 1 | dephosphorylation | up-regulates activity | 0.2 | nutrient-replete oocytes inhibit C2 via S135 phosphorylation catalyzed by calcium/calmodulin-dependent protein kinase II. We now show that C2 phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation. Moreover, we determined that S135 dephosphorylation is catalyzed by protein phosphatase-1 (PP1), wh... | SIGNOR-248564 |
P17861-2 | Q96EB6 | 0 | deacetylation | down-regulates activity | 0.379 | P300 increases the acetylation and protein stability of XBP1s, and enhances its transcriptional activity, whereas SIRT1 deacetylates XBP1s and inhibits its transcriptional activity.. The mRNA encoding the active spliced form of XBP1 (XBP1s) is generated from the unspliced form by IRE1 (inositol-requiring enzyme 1) duri... | SIGNOR-260430 |
Q12864 | P35222 | 2 | binding | up-regulates activity | 0.705 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265856 |
Q03135 | P06241 | 0 | phosphorylation | down-regulates activity | 0.721 | Caveolin-1 is phosphorylated on tyr(14) in response to both oxidative and hyperosmotic stress. In the present paper, we show that this phosphorylation requires activation of the src family kinase fyn.Therefore, | SIGNOR-118003 |
Q08378 | Q16584 | 0 | phosphorylation | up-regulates activity | 0.361 | In vitro kinase assays demonstrated that MLK3 directly phosphorylates golgin-160 in the N-terminal head region between residues 96 and 259. | SIGNOR-279065 |
P51451 | P12318 | 1 | phosphorylation | up-regulates activity | 0.436 | To identify the FcgammaRII-phosphorylating protein tyrosine kinase (PTK), we used the combination of an in vitro and an in vivo approach. In an in vitro assay using recombinant cytoplasmic tails of the different FcgammaRII isoforms as well as tyrosine exchange mutants, we show that each of the BCR-associated PTKs (Lyn,... | SIGNOR-249312 |
Q9NQS7 | Q96GD4 | 2 | binding | up-regulates | 0.974 | Using recombinant proteins, we found that aurora b kinase activity was stimulated by incenp and that the c-terminal region of incenp was sufficient for activation. | SIGNOR-86218 |
P52945 | O43791 | 0 | ubiquitination | down-regulates quantity | 0.326 | Pdx1 C terminus-interacting factor-1 (Pcif1, also known as SPOP) is a nuclear protein that inhibits Pdx1 transactivation. Here, we show that Pcif1 targets Pdx1 for ubiquitination and proteasomal degradation. | SIGNOR-268859 |
P23771 | Q99835 | 0 | null | up-regulates activity | 0.2 | That GATA is a downstream effector of the hedgehog pathway. | SIGNOR-253527 |
Q9H4X1 | P06493 | 2 | binding | up-regulates activity | 0.53 | RGC-32 was physically associated with cyclin-dependent kinase p34CDC2 and increased the kinase activity in vivo and in vitro. In addition, RGC-32 was phosphorylated by p34CDC2-cyclin B1 in vitro. Mutation of RGC-32 protein at Thr-91 prevented the p34CDC2-mediated phosphorylation and resulted in loss of p34CDC2 kinase e... | SIGNOR-262726 |
P68400 | P20042 | 1 | phosphorylation | up-regulates | 0.35 | The n-terminal domain of the human eif2beta subunit and the ck2 phosphorylation sites are required for its function. These results suggest that ser2 and ser67 contribute to the important role of the n-terminal region of eif2beta for its function in mammals. | SIGNOR-140994 |
Q05682 | Q00535 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.341 | Together, these data demonstrate that phosphorylation of caldesmon on Ser527 by Cdk5 serves to down regulate its stability. | SIGNOR-280215 |
Q96BR9 | Q8TBB1 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | LNX (ligand of Numb protein-X) is a RING finger and four PDZ domain-containing E3 ubiquitin ligase. Lnx-l induced K48-linked polyubiquitylation of Boz, leading to its proteasomal degradation in human 293T cells and in zebrafish embryos. | SIGNOR-272777 |
P52757 | P06239 | 0 | phosphorylation | down-regulates activity | 0.2 | We now demonstrate Lck-dependent phosphorylation of beta2-chimaerin in response to TCR triggering. We identify Tyr-153 as the Lck-dependent phosphorylation residue and show that its phosphorylation negatively regulates membrane stabilization of beta2-chimaerin, decreasing its GAP activity to Rac. | SIGNOR-276240 |
Q12798 | O43303 | 2 | binding | up-regulates activity | 0.483 | We report that CP110 interacts with two different Ca2+-binding proteins, calmodulin (CaM) and centrin, in vivo. our data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. | SIGNOR-265966 |
P04792 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.515 | Radioactive kinase assays confirmed that PKC\u03b4 phosphorylated Hsp27 at Ser78 and Ser82 ( Fig. 3 B). | SIGNOR-278425 |
O94901 | Q3KP22 | 2 | binding | up-regulates activity | 0.2 | In this study, we found that SUN1 not only interacted with TERB1 but also interacted with MAJIN, and the interaction of SUN1 with MAJIN is stronger than TERB1. We also found that SUN1 interacted with SPDYA, an activator of CDK2. | It will be of great interest to test this hypothesis to fully understand the mechanisms o... | SIGNOR-263300 |
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