IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P49137 | P07101 | 1 | phosphorylation | up-regulates activity | 0.52 | MAPKAP-K2 phosphorylates both Ser19 and Ser40 of TH. Tyrosine hydroxylase (TH) has been reported to require binding of 14-3-3 proteins for optimal activation by phosphorylation. | SIGNOR-250149 |
O15524 | P52333 | 2 | binding | down-regulates activity | 0.708 | SOCS proteins bind to janus kinase and to certain cytokine receptors and signaling molecules, thereby suppressing further signaling events. Studies have shown that SOCS proteins are key physiological regulators of inflammation. Recent studies have also demonstrated that SOCS1 and SOCS3 are important regulators of adapt... | SIGNOR-238642 |
P26441 | O75462 | 2 | binding | up-regulates | 0.39 | We recently demonstrated that cardiotrophin-like cytokine (clc) associates with the soluble orphan receptor cytokine-like factor-1 (clf) to form a heterodimeric cytokine that displayed activities only on cells expressing the tripartite cntf receptor on their surface | SIGNOR-106635 |
Q08828 | P63096 | 2 | binding | down-regulates activity | 0.552 | GTP-bound, active WT Gαi1 acts to inhibit AC, resulting in a decreased concentration of intracellular cAMP. | SIGNOR-256498 |
P17948 | P17948 | 2 | phosphorylation | up-regulates | 0.2 | Receptor tyrosine phosphorylation is crucial for signal transduction by creating high affinity binding sites for src homology 2 domain-containing molecules. By expressing the intracellular domain of flt-1/vascular endothelial growth factor receptor-1 in the baculosystem, we identified two major tyrosine phosphorylation... | SIGNOR-59762 |
P24941 | Q06830 | 1 | phosphorylation | down-regulates | 0.254 | Peroxiredoxin (prx) i is a member of the peroxiredoxin family of peroxidases and contains a consensus site (thr(90)-pro-lys-lys) for phosphorylation by cyclin-dependent kinases (cdks). This protein has now been shown to be phosphorylated specifically on thr(90) by several cdks, including cdc2, in vitro. Phosphorylation... | SIGNOR-87101 |
P47901 | P63096 | 2 | binding | up-regulates activity | 0.267 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257063 |
Q86UW7 | P60880 | 2 | binding | up-regulates activity | 0.266 | CAPS interacted independently with either syntaxin-1 or SNAP-25 suggesting that CAPS might promote QaQbc-SNARE heterodimer formation. CAPS binding to syntaxin-1 was mediated by the membrane-proximal C-terminal SNARE motif (H3) and membrane linker domain sequences of syntaxin-1 | SIGNOR-264339 |
P01562 | P17181 | 2 | binding | up-regulates | 0.651 | The present study describes a novel type i ifn receptor having the ability to bind and respond to several subtypes of ifn-a as well as to ifn-8. This 102 kda-51 kda receptor is essential for the activity of many type i ifns, as demonstrated with anti-receptor antibodies. | SIGNOR-36622 |
Q00526 | Q12800 | 1 | phosphorylation | down-regulates | 0.264 | In vitro, lsf is phosphorylated by cyclin e/cyclin-dependent kinase 2 (cdk2), cyclin c/cdk2, and cyclin c/cdk3, predominantly on s309. Phosphorylation by cyclin c/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of lsf during g1 progression | SIGNOR-184164 |
P25098 | Q16539 | 1 | phosphorylation | down-regulates | 0.2 | Phosphorylation of p38 by grk2 at the docking groove unveils a novel mechanism for inactivating p38mapk p38 associates with grk2 endogenously and is phosphorylated by grk2 at thr-123, a residue located at its docking groove. Mimicking phosphorylation at this site impairs the binding and activation of p38 by mkk6 and di... | SIGNOR-150152 |
P08754 | O00254 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257146 |
P56945 | Q15678 | 0 | dephosphorylation | down-regulates | 0.394 | We show that p130 crk-associated substrate (p130cas) is a direct substrate of ptpn14 and that ptpn14 specifically regulates p130cas phosphorylation at tyrosine residue 128 (y128) in colorectal cancer (crc) cells. We engineered crc cells homozygous for a p130cas y128f knock-in mutant and found that these cells exhibit s... | SIGNOR-197923 |
Q16760 | P17252 | 0 | phosphorylation | down-regulates activity | 0.366 | The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain. | SIGNOR-249265 |
P29474 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.568 | The phosphorylation of both S617 and S635 have also been shown to promote increased eNOS-derived NO release (Michell et al., 2002). The phosphorylaiton of S617 can be induced by PKA or Akt activity, and may serve to sensitize eNOS to calmodulin binding and modulate the phosphorylation of other eNOS sites | SIGNOR-251631 |
Q6N021 | O60674 | 0 | phosphorylation | up-regulates activity | 0.418 | Specifically, cytokine receptor-associated JAK2 phosphorylates TET2 at tyrosines 1939 and 1964. Phosphorylated TET2 interacts with the erythroid transcription factor KLF1, and this interaction with TET2 is increased upon exposure to erythropoietin. | SIGNOR-277289 |
Q99835 | P09341 | 2 | binding | up-regulates | 0.2 | We found that smo, by virtue of what appears to be constitutive activity, activates all members of the g(i) family but does not activate members of the g(s), g(q), and g(12) families. | SIGNOR-148484 |
Q9Y4K3 | P51617 | 2 | ubiquitination | up-regulates activity | 0.913 | K63-linked polyubiquitination of proximal signaling proteins is a common mechanism used by diverse innate immune receptors for recruiting IKK and activating NF-_B | SIGNOR-252252 |
Q9NQS7 | O14578 | 0 | phosphorylation | up-regulates activity | 0.426 | Figure 5.CIT-K phosphorylates INCENP. (a) Schematic diagram of INCENP structure illustrating the phosphorylated sites identified by MS. | SIGNOR-280232 |
P19429 | O75914 | 0 | phosphorylation | down-regulates | 0.2 | In vitro addition of pak3 to skinned rat cardiac fibres increased myofilament ca2+ sensitivity with no change in maximal ca2+-activated force [67]. These effects were associated with pak3-induced phosphorylation of myofilament proteins, including ctni which was phosphorylated at a novel site, ser149, located in the reg... | SIGNOR-134593 |
Q9H093 | Q9Y484 | 1 | phosphorylation | up-regulates activity | 0.262 | WIPI4 is stimulated by AMPK, NUAK2 and BRSK2. This finding is supported by the results of our kinome screening, which identified AMPK and the AMKP-related kinases NUAK2 and BRSK2, all of which function downstream of LKB1 (ref. 69) and stimulate the localization of WIPI4 to nascent autophagosomes. | SIGNOR-268481 |
Q05397 | Q14247 | 1 | phosphorylation | down-regulates activity | 0.745 | FAK directly phosphorylates cortactin at Y421 and Y466 and over-expression of cortactin Y421, Y466, and Y482 mutated to phenylalanine (3YF) prevented FAK-enhanced FA turnover and cell motility.|GFP-FAK re-expression in FAK-/- MEFs enhances FA turnover (XREF_FIG) and cortactin knockdown slows FA turnover (XREF_FIG). | SIGNOR-278283 |
Q8WWW0 | Q9NS23 | 2 | binding | up-regulates activity | 0.543 | NORE1A can heterodimerize with RASSF1A and, thus, mediate K-Ras regulation of RASSF1A | SIGNOR-249587 |
P10636 | Q7KZI7 | 0 | phosphorylation | down-regulates activity | 0.707 | We have studied the relationship between the phosphorylation oftau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. By contrast, MARK and PKA phosphorylate several sites within the repeats (notably theKXGS motifs including Ser262, Ser324, and Ser356, plus Ser320); in addition PKA phosphorylates so... | SIGNOR-275436 |
P60568 | Q03060 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.481 | In this study we show that CREM is transcriptionally induced in T cells following stimulation through CD3 and CD28, binds to the IL-2 promoter in vivo, and suppresses IL-2 production. | SIGNOR-261576 |
O43353 | Q96J02 | 2 | binding | up-regulates activity | 0.528 | ITCH preferentially binds to RIPK2, promoting its K63-linked ubiquitination while simultaneously protecting YAP protein levels and maintaining its nuclear localization in CRC cells. | SIGNOR-280458 |
P41220 | Q13976 | 0 | phosphorylation | up-regulates activity | 0.68 | Thus, PKGI-alpha binds to, phosphorylates and activates RGS-2, attenuating receptor-mediated vascular contraction. | SIGNOR-249241 |
P13569 | Q8IWU2 | 0 | phosphorylation | down-regulates activity | 0.401 | The present study discovered that in human airway epithelial cells CFTR endocytosis is regulated by the LMTK2-mediated phosphorylation of CFTR-Ser737 that decreases the cell surface density of CFTR Cl\u2212 channels and inhibits CFTR-mediated Cl\u2212 secretion.|Together, the above results demonstrate that the LMTK2 ph... | SIGNOR-278227 |
Q12888 | Q9NS91 | 0 | ubiquitination | up-regulates activity | 0.611 | RAD18 associates with 53BP1 and is recruited to DSB sites in a 53BP1 dependent manner specifically during G1-phase, RAD18 monoubiquitinates KBD domain of 53BP1 at lysine 1268 in vitro.|These results suggest that RAD18 directed modification at Lysine 1268 of 53BP1 promotes the retention of 53BP1 at DSBs. | SIGNOR-278593 |
O95817 | Q05655 | 0 | phosphorylation | up-regulates | 0.251 | Pkc_-mediated phosphorylation of bag3 at ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid cancer fro cells. we showed that bag3 was implicated in epithelial-mesenchymal transition (emt) procedure, and phosphorylation state at ser187 site had a critical role in emt regulation by... | SIGNOR-199316 |
Q9UL68 | P46937 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression. Examination of the gene expression changes in cells expressing Myt1 or Myt1l suggests that both repress expression of the YAP1 transcriptional coactivator, which functions primarily in the Hippo signaling pathway. Expre... | SIGNOR-266778 |
O95837 | P25090 | 2 | binding | up-regulates activity | 0.435 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256888 |
P0DP24 | P48454 | 2 | binding | up-regulates | 0.521 | Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. | SIGNOR-266324 |
P22001 | P12931 | 0 | phosphorylation | up-regulates | 0.31 | The shaker family k+ channel protein, kv1.3, is tyrosine phosphorylated by v-src kinase at tyr137 and tyr449 to modulate current magnitude and kinetic properties. | SIGNOR-114641 |
P47989 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.2 | Finally, threonine 222 of XOR is the critical target site for CDK5 dependent activation of XOR.|Once we determined CDK5 was necessary for hypoxia induced hyperactivation of XOR, we tested whether CDK5 was sufficient to phosphorylate XOR and induce increased enzymatic activity in a cell free system. | SIGNOR-280221 |
O96017 | Q2M385 | 1 | phosphorylation | up-regulates activity | 0.2 | Chk2 phosphorylates Mps1-T288 after DNA damage.|In the present study, we show that Chk2 stabilizes Mps1 protein and phosphorylates Aurora B-B-serine 331 to prevent mitotic exit in vertebrate cells when the majority of kinetochores are unattached. | SIGNOR-279160 |
P31749 | P29317 | 1 | phosphorylation | up-regulates activity | 0.355 | As non-canonical EphA2 activation requires phosphorylation of EphA2 at serine 897 by pAkt (Fig.\u00a02b), we sought to determine the effect of PTEN-mediated Akt regulation on invasion. | SIGNOR-279787 |
P24941 | Q9H3D4 | 1 | phosphorylation | down-regulates | 0.246 | Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increas... | SIGNOR-180759 |
P53779 | P52564 | 0 | phosphorylation | up-regulates | 0.464 | A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subgroups of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) | SIGNOR-45363 |
P19793 | P28482 | 0 | phosphorylation | down-regulates activity | 0.534 | In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate ... | SIGNOR-262958 |
P11926 | P25054 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.268 | APC-dependent regulation of ornithine decarboxylase in human colon tumor cells|Upon induction of APC expression, ODC promoter activity and RNA levels were suppressed | SIGNOR-253670 |
P31749 | P10275 | 1 | phosphorylation | down-regulates activity | 0.586 | Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Here, we demonstrate that akt phosphorylates the androgen receptor (ar) at ser-210 and ser-790 | SIGNOR-108508 |
P23760 | P50222 | 2 | binding | up-regulates activity | 0.404 | We show that Mox1 and Mox2 proteins are capable of interacting with Pax1 and Pax3. We propose that the Mox family of homeodomain proteins participates in the molecular signaling network regulating the diverse events of somite development through the physical interaction with the Pax1 and Pax3 members of the Pax family. | SIGNOR-222238 |
Q9HBE5 | Q9HBE4 | 2 | binding | up-regulates | 0.901 | Il-21 mediates its biological effects via the il-21r in conjunction with the common receptor gamma-chain that is also shared by members of the il-2 family | SIGNOR-143849 |
P18848 | P35638 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.816 | ATF4 also induces another bZIP protein C/EBP-homologous protein (CHOP), which is responsible for triggering apoptosis in cells under prolonged ER stress. ATF4 and CHOP further induce growth arrest and DNA damage–inducible protein 34 (GADD34),a regulatory subunit of protein phosphatase 1 (PP1) that dephosphorylates eIF2... | SIGNOR-260170 |
Q13635 | Q15465 | 2 | binding | down-regulates activity | 0.942 | In the responding cell, active Hedgehog binds to its receptor Patched, a 12-pass transmembrane protein, which frees Smoothened, an adjacent 7-pass transmembrane protein, for downstream signaling.Thus, a balance is created by the antagonism of Hedgehog and Patched, whose relative concentrations alternate with respect to... | SIGNOR-118615 |
P11308 | O00501 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.224 | ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene. | SIGNOR-261596 |
Q15139 | Q9Y5P4 | 1 | phosphorylation | down-regulates | 0.2 | In this study, we identify cert as a novel in vivo pkd substrate. Phosphorylation on serine 132 by pkd decreases the affinity of cert toward its lipid target phosphatidylinositol 4-phosphate at golgi membranes and reduces ceramide transfer activity | SIGNOR-156500 |
Q14680 | Q05397 | 1 | phosphorylation | up-regulates activity | 0.2 | As the aforementioned results showed that MELK promotes FAK phosphorylation, and it is well known that FAK is an important regulator of cell migration and invasion, we speculated that MELK could regulate cell migration and invasion via the FAK/Paxillin pathway.|Finally, knockdown of MELK decreased the phosphorylation o... | SIGNOR-279230 |
P22694 | P08138 | 1 | phosphorylation | up-regulates | 0.625 | Pka phosphorylates the p75 receptor and regulates its localization to lipid rafts. activation of camp?PKA Is required for translocation of p75ntr to lipid rafts, and for biochemical and biological activities of p75ntr, such as inactivation of rho and the neurite outgrowth. | SIGNOR-99755 |
P49841 | P35869 | 1 | phosphorylation | up-regulates activity | 0.25 | A proposed model of GSK3β role on AHR function and degradation. AHR is phosphorylated by GSK3β in a p23-dependent manner in HeLa cells. This phosphorylation is required for optimal activation of the ligand-dependent AHR target gene transcription. After phosphorylation, AHR is K63-ubiquitinated and is targeted for the L... | SIGNOR-276664 |
P20749 | Q9BZK7 | 0 | ubiquitination | down-regulates | 0.401 | We also defined the e3 ligase tblr1 as a protein involved in bcl-3 degradation | SIGNOR-166111 |
O15350 | Q96J02 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.566 | Collectively, our present findings suggest that MDM2 promotes Itch-mediated degradation of p73 through the interaction with Itch in HeLa cells | SIGNOR-278699 |
Q00526 | Q14934 | 1 | phosphorylation | up-regulates activity | 0.369 | CDK3 enhances the transactivation and transcription activity of NFAT3.|NFAT3 can be phosphorylated by CDK3 at Ser259, which is critical for its transactivation activity and cell transformation. | SIGNOR-278511 |
Q9GZY8 | O94806 | 0 | phosphorylation | up-regulates activity | 0.2 | The mitochondrial fission factor (MFF), the main mitochondrial receptor for the Dynamin-related protein 1 (DRP1), is directly phosphorylated by Protein Kinase D (PKD) specifically during mitosis. PKD-dependent MFF phosphorylation is required and sufficient for mitochondrial fission in mitotic but not in interphasic cel... | SIGNOR-275945 |
O00418 | P06493 | 0 | phosphorylation | down-regulates | 0.368 | Phosphorylation at ser359 inhibits eef2k activity even at high calcium concentrations. we demonstrate that cdc2 contributes to controlling eef2 phosphorylation in cells. inactivation of eef2k by cdc2 may serve to keep eef2 active during mitosis | SIGNOR-177982 |
P68400 | O15266 | 1 | phosphorylation | up-regulates | 0.338 | We show also that casein kinase ii phosphorylates shox on serine 106 efficiently in vitro. S106a shox mutant, defective in phosphorylation, does not activate transcription and fails to induce cell-cycle arrest and apoptosis | SIGNOR-142875 |
Q5S007 | P26038 | 1 | phosphorylation | up-regulates activity | 0.551 | This led to the discovery that moesin, a protein which anchors the actin cytoskeleton to the plasma membrane, is efficiently phosphorylated by lrrk2, at thr558. Moesin phosphorylation could be essential to support the cytoskeletal changes accompanying this process. | SIGNOR-154498 |
Q12933 | Q14164 | 0 | phosphorylation | up-regulates activity | 0.686 | IKKepsilon phosphorylates TRAF2 at Ser11 to activate NF-kappaB and promote malignant transformation. | SIGNOR-279195 |
P07949 | Q99704 | 2 | binding | up-regulates | 0.614 | Dok proteins directly associate with tyrosine 1062 of ret and could be its substrates. Phosphorylation of dok1 is necessary for interaction with ras-gap in vitro and in vivo. Dok1 is a negative regulator for the ras/erk signaling pathway activated by ret. | SIGNOR-90158 |
P48454 | P0DP23 | 2 | binding | up-regulates | 0.661 | Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. | SIGNOR-114104 |
P0C6X7-PRO_0000037311 | Q9Y4K3 | 1 | deubiquitination | down-regulates activity | 0.2 | Also, SARS-CoVPLPro catalyzed deubiquitination ofTNF-receptor-associatedfactor3(TRAF3)and TRAF6, thereby suppressing IFN-I and proinflammatory cytokines induced by TLR7 agonist | SIGNOR-260248 |
Q9UHD2 | Q14289 | 0 | phosphorylation | up-regulates activity | 0.266 | Mechanistically, we demonstrate that PTK2B directly phosphorylates residue Tyr591 of TBK1, which increases TBK1 oligomerization and activation. | SIGNOR-277910 |
Q9UKV5 | Q99574 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.296 | In this study, we demonstrate that two ER-associated E3 ligases, Hrd1 and gp78, are involved in the ubiquitination and degradation of mutant neuroserpin. | SIGNOR-272756 |
P53779 | Q93045 | 1 | phosphorylation | down-regulates | 0.444 | We demonstrate that purified scg10 can be phosphorylated by two subclasses of mitogen-activated protein (map) kinases, c-jun n-terminal/stress-activated protein kinase (jnk/sapk) and p38 map kinase;jnk3/sapkbeta phosphorylation occurs at ser-62 and ser-73, residues that result in reduced microtubule-destabilizing activ... | SIGNOR-112114 |
P12931 | P04626 | 1 | phosphorylation | up-regulates activity | 0.615 | In addition, the c-Src inhibitor 4-(4\u2019-phenoxyanilino)-6,7-dimethoxyquinazoline prevented SP-induced activation of HER2.|On the other hand, c-Src directly phosphorylates the cytoplasmic tails of both EGFR and HER2, allowing the binding of scaffold proteins that will further activate signal transduction. | SIGNOR-279432 |
P67870 | Q99250 | 1 | phosphorylation | up-regulates activity | 0.2 | We found that the ankyrin-binding motif of Na(v)1.2 that determines channel concentration at the AIS depends on a glutamate residue (E1111), but also on several serine residues (S1112, S1124, and S1126). We showed that phosphorylation of these residues by protein kinase CK2 (CK2) regulates Na(v) channel interaction wit... | SIGNOR-275752 |
P06213 | P35568 | 1 | phosphorylation | up-regulates activity | 0.914 | All known IRS proteins contain multiple YXXM motifs that upon phosphorylation by activated insulin receptors A previous study using phosphopeptides suggested that tyrosine-phosphorylated YXXM motifs at positions 608 and 939 in rat IRS-1 bind with high affinity to SH2 domains of p85, and motifs at positions 460 and 987 ... | SIGNOR-235975 |
Q6UUV7 | P57059 | 0 | phosphorylation | down-regulates | 0.418 | These results suggested that sik1 could phosphorylate all torcs and thereby repress their transactivation activities. | SIGNOR-147703 |
O43561 | P15498 | 2 | binding | up-regulates activity | 0.752 | By substituting these tyrosine residues in LAT with phenylalanine and by utilizing phosphorylated peptides derived from these sites, we mapped the tyrosine residues in LAT required for the direct interaction and activation of Vav, p85/p110alpha and phospholipase Cgamma1 (PLCgamma1). Our results indicate that Tyr(226) a... | SIGNOR-246045 |
P09471 | Q9BPV8 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256749 |
O00401 | P12931 | 0 | phosphorylation | up-regulates activity | 0.759 | An Src family tyrosine kinase, v-Src, phosphorylates and activates N-WASP. | SIGNOR-279487 |
P78352 | Q8N2Q7 | 0 | relocalization | up-regulates activity | 0.776 | Like NRXNs, NLGNs bind to intracellular PDZ-domain proteins, but in contrast to NRXNs, NLGNs bind to class I PDZ domains such as those contained in PSD95, a postsynaptic MAGUK protein65. PSD95 and its homologues are centrally involved in recruiting glutamate receptors at postsynaptic sites66. Similarly to CASK, PSD95 b... | SIGNOR-264191 |
P19438 | P02533 | 2 | binding | down-regulates activity | 0.265 | TRADD specifically bound K18 and K14, type I (acidic) keratins. it is possible that epidermal K14 may function as an inhibitor of TNF–TNFR1 signaling through an association with TRADD. | SIGNOR-251906 |
P28328 | P62837 | 2 | binding | up-regulates activity | 0.611 | Here we report on the identification of the protein-ubiquitin ligases that are responsible for the ubiquitination of the peroxisomal protein import receptor Pex5. It is demonstrated that each of the three RING peroxins Pex2, Pex10, and Pex12 exhibits ubiquitin-protein isopeptide ligase activity. Our results show that P... | SIGNOR-253025 |
P18031 | P51608 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | In this study, we have demonstrated that the PTPN1 gene, which encodes PTP1B, was a direct target of MECP2 and that PTP1B protein levels were dramatically increased in Mecp2-mutant mice and in fibroblasts derived from patients with RTT. | SIGNOR-264546 |
P52306 | P62834 | 2 | binding | up-regulates | 0.42 | Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob | SIGNOR-171482 |
Q8NFZ0 | Q06609 | 2 | binding | up-regulates activity | 0.2 | The F-box DNA helicase 1 (FBH1) is a 3'-5' DNA helicase with a putative function as a negative regulator of HR. It is the only known DNA helicase to contain an F-box, suggesting that one of its functions is to act as a ubiquitin ligase as part of an SCF (SKP1, CUL1 and F-box) complex. Here we report that the central pl... | SIGNOR-272451 |
P42575 | P62140 | 0 | dephosphorylation | up-regulates activity | 0.2 | Nutrient-replete oocytes inhibit C2 via S135 phosphorylation catalyzed by calcium/calmodulin-dependent protein kinase II. We now show that C2 phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation. Moreover, we determined that S135 dephosphorylation is catalyzed by protein phosphatase-1 (PP1), wh... | SIGNOR-248576 |
P62330 | O43150 | 0 | gtpase-activating protein | up-regulates activity | 0.668 | Pap is a multidomain protein composed of an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal SH3 domain. In addition, in vitro recombinant Pap exhibits strong GTPase-activating prot... | SIGNOR-269706 |
P09237 | P10451 | 1 | cleavage | up-regulates activity | 0.706 | In this study, we found a novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to α9β1 integrin. Importantly, this novel motif is involved in the development of anti-type II collagen antibody-induced arthritis (CAIA). This study provides the first in vitro and in vivo evidence tha... | SIGNOR-253321 |
O15111 | Q92905 | 1 | phosphorylation | down-regulates activity | 0.325 | Overexpression of IKKalpha or IKKbeta leads to enhanced phosphorylation of CSN5, the catalytic subunit for CSN deneddylase activity. Mutational analyses have revealed that phosphorylation at serine 201 and threonine 205 of CSN5 impairs CSN-mediated deneddylation activity in vitro. | SIGNOR-275507 |
P16234 | P04085 | 2 | binding | up-regulates | 0.773 | Platelet-derived growth factors (pdgf) constitute a family of four gene products (pdgf-a-d) acting by means of two receptor tyrosine kinases, pdgfr alpha and beta. Three of the ligands (pdgf-a, -b, and -c) bind to pdgfr alpha with high affinity. | SIGNOR-114268 |
O75417 | Q00987 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation | SIGNOR-272729 |
Q15797 | P46937 | 2 | binding | up-regulates | 0.575 | Yap binds to the phosphorylated smad1 to activate gene transcription. | SIGNOR-201462 |
O00141 | P49815 | 1 | phosphorylation | down-regulates activity | 0.579 | SGK1, which is activated by PDK1, contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2. | SIGNOR-277266 |
P43378 | P10912 | 1 | dephosphorylation | down-regulates activity | 0.314 | Protein tyrosine phosphatases (PTPs) play key roles in switching off tyrosine phosphorylation cascades, such as initiated by cytokine receptors. We have used substrate-trapping mutants of a large set of PTPs to identify members of the PTP family that have substrate specificity for the phosphorylated human GH receptor (... | SIGNOR-248505 |
P07585 | P09237 | 0 | cleavage | down-regulates quantity by destabilization | 0.61 | Degradation of decorin by matrix metalloproteinases. These data indicate proteolytic degradation of DCN by MMP-2, MMP-3 and MMP-7, and suggest the possibility that, under pathophysiological conditions, the digestion by the MMPs may induce tissue reactions mediated by TGF-beta1 released from DCN in the connective tissu... | SIGNOR-256352 |
P49427 | Q15418 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.335 | RSK1 phosphorylated Thr162 on UBE2R1.RSK1 induced self-ubiquitination and destabilisation of UBE2R1 by phosphorylation. | SIGNOR-277330 |
Q8NEA6 | Q9UMX1 | 2 | binding | down-regulates | 0.381 | These data indicate that the inhibition of glis3-mediated transactivation by sufu appears to rely on the interaction with glis3 through the ygh motif and is not related to an effect on the general transcriptional machinery | SIGNOR-173573 |
Q02779 | Q13562 | 2 | binding | up-regulates activity | 0.333 | we identified two proteins that interact with ND, huntingtin-associated protein 1 (HAP1) and mixed-lineage kinase 2 (MLK2). Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 | SIGNOR-234599 |
P49238 | P78423 | 2 | binding | up-regulates | 0.785 | Fractalkine/cx3cl1 is a membrane-tethered chemokine that functions as a chemoattractant and adhesion protein by interacting with the receptor cx3cr1. | SIGNOR-109135 |
P24941 | P17480 | 1 | phosphorylation | up-regulates activity | 0.372 | Phosphorylation of ubf at serine 388 is required for interaction with rna polymerase i and activation of rdna transcription. After g(1) progression ubf is phosphorylated at serine 388 by cdk2/cyclin e and cdk2/cyclin a. Conversion of serine 388 to glycine abolishes ubf activity | SIGNOR-235419 |
O95837 | P28221 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257208 |
Q8WUP2 | Q14315 | 2 | binding | up-regulates activity | 0.789 | Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin a... | SIGNOR-266107 |
P42345 | Q9Y6M1 | 1 | phosphorylation | up-regulates activity | 0.2 | IGF2BP2 can be activated by mTOR and promotes its binding to IGF2 mRNA of IGF2 thereby leading to diabetes mellitus [ xref , xref ].|In addition, phosphorylation of IGF2BP2 in the linker region between RRM2 and KH1 by mTOR promotes its binding to the IGF leader 3 mRNA 5\u2032-UTR, enhancing the initiation of IGF2 trans... | SIGNOR-280046 |
P31323 | O43164 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | Praja2 controls the stability of PKA regulatory subunits. Praja2 ubiquitylates RIIα/β subunits. Subunits | SIGNOR-271858 |
P49335 | P20264 | 2 | binding | up-regulates activity | 0.314 | POU proteins (Brain-1, Brain-2, Brain-4 and SCIP) serve as transcriptional transactivators. if they were to form homomeric and heteromeric complexes with each other, depending on the particular combination, they might have different DNA-binding specificities and, thus, activate different genes. | SIGNOR-220127 |
P13349 | P17661 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.241 | Desmin, the muscle specific intermediate filament (IF) protein, is expressed at low levels in myoblasts and at the onset of differentiation its expression increases several fold. In an effort to explore the mechanism involved in the tissue-specific and developmentally regulated expression of desmin, we have isolated th... | SIGNOR-241494 |
P49748 | P17612 | 0 | phosphorylation | up-regulates activity | 0.2 | As shown in Fig. 2C, an in vitro kinase assay carried out using PKA and a GST fusion protein containing the COOH-terminal 258 amino acids showed the protein to be efficiently phosphorylated in a time-dependent manner. |Furthermore, a phosphorylation-negative mutant (S586A) VLCAD shows reduced electron transfer activity... | SIGNOR-264422 |
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