IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q9UNZ2 | P07711 | 2 | binding | down-regulates activity | 0.2 | The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L. | SIGNOR-265043 |
P48730 | P04637 | 1 | phosphorylation | up-regulates | 0.578 | Here we show that the direct association between a p53 n-terminal peptide and mdm2 is disrupted by phosphorylation of the peptide on thr(18) but not by phosphorylation at other n-terminal sites, including ser(15) and ser(37). Thr(18) was phosphorylated in vitro by casein kinase (ck1). | SIGNOR-75889 |
Q9UNE7 | Q99828 | 1 | ubiquitination | down-regulates quantity | 0.2 | All those were suggesting that CHIP promotes CIB1 ubiquitination via the Lys 48 residue of ubiquitin.|K10 and K65 were the Lysine (K) residues for CHIP mediated CIB1 degradation. | SIGNOR-278721 |
Q99683 | Q14680 | 0 | phosphorylation | up-regulates activity | 0.271 | MELK, as an upstream kinase of ASK1, phosphorylates threonine 838 in an activation loop of human ASK1, thereby stimulating ASK1 kinase activity. | SIGNOR-280039 |
P12931 | P12931 | 2 | phosphorylation | down-regulates activity | 0.2 | Rapid digestion of pp60c-src tyrosine kinase (src TK) in combination with electrospray ionization mass spectrometry enabled the determination of the time course for autophosphorylation of three tyrosine sites (Y338, Y419, and Y530) and a correlation with src TK activity. Here, conditions were identified which promoted ... | SIGNOR-43315 |
P35222 | Q13308 | 2 | binding | down-regulates | 0.403 | Ptk7 has been strongly implicated in pcp and, like many pcp activators, is a negative regulator of beta-catenin-dependent wnt. | SIGNOR-199536 |
P17302 | P17252 | 0 | phosphorylation | down-regulates | 0.535 | Using immunoblotting and phosphospecific antibodies we were able to show that serine-262 (s262) on cx43 becomes phosphorylated in response to growth factor or pkc stimulation of cardiomyocytes.In cell-cell contact forming cultures, the s262d mutation reversed while the s262a mutation increased the inhibitory effect of ... | SIGNOR-120907 |
Q12923 | P35568 | 1 | dephosphorylation | down-regulates activity | 0.466 | Finally, we report that PTPL1 expression is sufficient to block the IRS-1/phosphatidylinositol 3-kinase/Akt signaling pathway, to inhibit the insulin-like growth factor-I effect on cell survival, and to induce apoptosis.|We first show by complementary approaches that PTPL1 specifically dephosphorylates insulin receptor... | SIGNOR-277053 |
Q15118 | P08559 | 1 | phosphorylation | down-regulates activity | 0.794 | Here we report that the four isoenzymes of protein kinase responsible for the phosphorylation and inactivation of pyruvate dehydrogenase (pdk1, pdk2, pdk3 and pdk4) differ in their abilities to phosphorylate the enzyme. Pdk1 can phosphorylate all three sites (s232, s293, s300), whereas pdk2, pdk3 and pdk4 each phosphor... | SIGNOR-109551 |
Q15078 | P20807 | 0 | cleavage | up-regulates activity | 0.261 | Calpains also modulate the activity of CDK5. Physiologically, CDK 5 is activated by p35 and its cleaved product p25. The latter has a longer half life than p35 and therefore it is a more potent activator of CDK5. The cleavage of p35 to p25 is mediated by calpain | SIGNOR-251604 |
Q96PV0 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.383 | CDK5 increases recombinant SYNGAP1 activity on Ras-GAP by 98% and its Rap-GAP activity by 20%.|Interestingly, phosphorylation of SYNGAP1 by CDK5 and CaMKII increases overall SYNGAP1 activity, but also alters the ratio of its GAP activity towards Ras- and Rap-GTPases. | SIGNOR-279157 |
O60885 | Q96QE3 | 2 | binding | up-regulates | 0.35 | ATAD5 Interacts with BRD4 through a Conserved BET Protein-Binding Domain. BRD4-ATAD5 binds to acetyl-histones in nascent chromatin. BRD4 release from chromatin correlates with PCNA unloading. Disruption of the interaction between BRD4 and acetyl-histones or between BRD4 and ATAD5 reduces the PCNA amount on chromatin. | SIGNOR-266412 |
Q5JU85 | P78352 | 1 | relocalization | up-regulates activity | 0.472 | Here, we characterized IQ-ArfGEF/BRAG1, a guanine nucleotide exchange factor (GEF) for Arf6, in the mouse brain. In vivo Arf pull down assay demonstrated that IQ-ArfGEF/BRAG1 activated Arf6 more potently than Arf1.IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynapti... | SIGNOR-264907 |
P49585 | P08047 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Sp1 and Sp3 function as transcriptional activators of the Ctpct promoter | SIGNOR-266231 |
Q96BI3 | Q92542 | 2 | binding | up-regulates | 0.967 | By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain. | SIGNOR-93259 |
Q13887 | Q14258 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.482 | The oestrogen-inducible E3 ligase EFP (oestrogen-responsive finger protein) was identified as a key player in oestrogen-mediated degradation of KLF5, as knockdown and overexpression of EFP increased and decreased KLF5 protein levels respectively, and the decrease continued even when protein synthesis was blocked. | SIGNOR-271908 |
P00390 | Q13131 | 0 | phosphorylation | up-regulates activity | 0.288 | Mechanistically, AMPKα1 regulate the glutathione reductase (GSR) phosphorylation possibly through residue Thr507 which enhances its activity. | SIGNOR-273734 |
P52655 | P19784 | 0 | phosphorylation | up-regulates activity | 0.374 | We now show that human TFIIA is phosphorylated in vivo on serine residues that are partially conserved between yeast and human TFIIA large subunits. Alanine substitution mutation of serine residues 316 and 321 in TFIIA alphabeta reduced TFIIA phosphorylation significantly in vivo. Additional alanine substitutions at se... | SIGNOR-250996 |
P09619 | Q05397 | 1 | phosphorylation | up-regulates | 0.553 | In this study, we demonstrate that growth factor receptors including hepatocyte growth factor receptor met, epidermal growth factor receptor, and platelet-derived growth factor receptor directly phosphorylate fak on tyr194 in the ferm domain collectively, this study provides the first example to explain how fak is act... | SIGNOR-167658 |
P41161 | Q14938 | 0 | transcriptional regulation | down-regulates quantity | 0.2 | By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles f... | SIGNOR-268886 |
P68400 | Q92688 | 1 | phosphorylation | up-regulates | 0.234 | Here, we are able to report that casein kinase 2 (ck2) phosphorylates april on residue threonine244 (thr(244)) and demonstrate that the ck2-specific inhibitor 4,5,6,7-tetrabromo-2-azabenzimidazole abolishes cd83 expression in activated jurkat t cells by interfering with the nucleocytoplasmic translocation of cd83 mrna | SIGNOR-183158 |
O14920 | Q16875 | 1 | phosphorylation | down-regulates activity | 0.29 | IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.We demonstrate that IKKβ directly interacts with and phosphorylates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase isoform 3 (PFKFB3), a major driver of aerobic glycolysis, at Ser269 upon glutamine deprivation ... | SIGNOR-277278 |
Q9GZQ8 | P19484 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.391 | As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes; | SIGNOR-276559 |
P35222 | P46937 | 2 | binding | up-regulates | 0.531 | Additionally, the hippo and wnts also cooperate in the nucleus, where yap interacts with beta-catenin and induces the expression of canonical wnt target genes, such as sox2 and snai2 in mouse heart tissue. | SIGNOR-201939 |
Q8N4X5 | P42336 | 2 | binding | up-regulates activity | 0.2 | RET/PTC induced robust tyrosine phosphorylation of XB130, which promoted its subsequent association with the p85alpha subunit of phosphatidylinositol 3-kinase (PI 3-kinase). We identified tyrosine 54 of XB130 as the major target of RET/PTC-mediated phosphorylation and a critical binding site for the SH2 domains of p85a... | SIGNOR-263193 |
P41221 | O75581 | 2 | binding | up-regulates activity | 0.758 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-131841 |
P07737 | P61586 | 0 | null | up-regulates activity | 0.569 | We find that the small GTPase Rho regulates R-cadherin adherens junction formation via Dia1 (also known as p140mDia) and profilin-1-mediated signaling pathway. The role played by Rho in regulating R-cadherin is underscored by the fact that constitutively active RhoA(Q63L) induces R-cadherin junction formation in MDA-MB... | SIGNOR-253109 |
P04637 | P17844 | 2 | binding | up-regulates | 0.702 | The dead box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor | SIGNOR-133341 |
B2RTY4 | P61586 | 1 | gtpase-activating protein | down-regulates activity | 0.565 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260508 |
P22694 | Q92917 | 1 | phosphorylation | up-regulates activity | 0.307 | Using yeast two-hybrid screening with the PKA Cβ2 subunit as bait we identified GPKOW, also known as MOS2 homolog or T54 protein, as an interaction partner for Cβ2.PKA phosphorylates GPKOW at S27 and T316 in vitro. GPKOWs ability to bind RNA is sensitive to mutations of its PKA phosphorylation sites. | SIGNOR-266298 |
O75385 | Q9C0C7 | 1 | phosphorylation | up-regulates | 0.695 | When autophagy is induced, ulk1 phosphorylates ambra1, releasing the autophagy core complex from dynein. Its subsequent relocalization to the endoplasmic reticulum enables autophagosome nucleation. Ambra1-dlc1 dissociates from the dynein complex upon ulk1-dependent ambra1 phosphorylation. | SIGNOR-168292 |
Q9Y4K3 | O43474 | 1 | ubiquitination | up-regulates quantity by stabilization | 0.285 | We further found that inhibition of polo-like kinase 1 could downregulate the expression of KLF4 and that PLK1 directly phosphorylated KLF4 at Ser234. Notably, phosphorylation of KLF4 by PLK1 caused the recruitment and binding of the E3 ligase TRAF6, which resulted in KLF4 K32 K63-linked ubiquitination and stabilizatio... | SIGNOR-277464 |
Q8NFZ3 | P58400 | 2 | binding | up-regulates activity | 0.2 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264148 |
P22612 | Q14896 | 1 | phosphorylation | up-regulates | 0.275 | Phosphorylation of cmybp-c by pka speeds actomyosin interactions and contributes to increased cardiac contractility following _-adrenergic stimulation.7, 8 phosphorylation by pka is essential for proper cardiac function /for the human isoform, three pka sites were previously identified (ser275, ser284, and ser304) /our... | SIGNOR-163788 |
P07948 | P43405 | 1 | phosphorylation | up-regulates activity | 0.61 | Lyn phosphorylates and activates Syk and LAT. | SIGNOR-279415 |
P28360 | P20226 | 2 | binding | down-regulates activity | 0.397 | Msx-1 is a potent transcriptional repressor and that this activity is independent of its DNA binding function. Here we show that Msx-1 interacts directly with the TATA binding protein (TBP) but not with several other general transcription factors. This interaction is mediated by the Msx-1 homeodomain, specifically thro... | SIGNOR-240401 |
O15350 | P53350 | 0 | phosphorylation | down-regulates | 0.51 | P73-mediated transcriptional activity is negatively regulated by polo-like kinase 1. tap73 is phosphorylated by this kinase on threonine-27 (thr-27) within the ta domain. | SIGNOR-178253 |
P24071 | P49840 | 0 | phosphorylation | down-regulates activity | 0.2 | GSK-3 is constitutively active in the absence of cytokine stimulation and can phosphorylate S263, keeping FcalphaRI in the inactive state. | SIGNOR-264856 |
Q9Y5I2 | Q9Y5F6 | 2 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265705 |
P63096 | Q9GZQ4 | 2 | binding | up-regulates activity | 0.435 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256731 |
Q96J02 | P45983 | 0 | phosphorylation | up-regulates activity | 0.654 | Itch undergoes JNK1-mediated phosphorylation that greatly enhances its enzymatic activity. To investigate how phosphorylation activates an E3 Ub ligase we have identified the JNK1 phosphorylation sites within Itch as S199, S232, and T222 | SIGNOR-245323 |
P59594 | Q9H2X3 | 2 | binding | up-regulates activity | 0.2 | Here we show that DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. | SIGNOR-260269 |
P28482 | Q07869 | 1 | phosphorylation | up-regulates activity | 0.578 | We now demonstrate that amino acids 1-92 of hPPARalpha contain an activation function (AF)-1-like domain, which is further activated by insulin through a pathway involving the mitogen-activated protein kinases p42 and p44. Further analysis of the amino-terminal region of PPARalpha revealed that the insulin-induced tran... | SIGNOR-249434 |
O60716 | P22223 | 2 | binding | up-regulates quantity by stabilization | 0.751 | To clarify the role of p120 in mammalian cells, we have knocked down p120 with siRNA in cells expressing epithelial (E-), placental (P-), neuronal (N-), and vascular endothelial (VE-) cadherins. We report that each of these cadherins, as well as α- and β-catenins, were rapidly degraded in the absence of p120, resulting... | SIGNOR-252124 |
P63244 | Q5JWF2 | 2 | binding | down-regulates activity | 0.2 | The results showed that RACK1 severed as an oncogene to enhance the proliferation capacity of liver cancer cell lines, meanwhile, downregulated GNA14 expression in Huh7 cell lines reversed the effects of RACK1 on cell proliferation | SIGNOR-278048 |
O43379 | Q99759 | 2 | relocalization | up-regulates activity | 0.2 | In the WT brain, the WDR62 scaffold organizes a protein complex including MEKK3, MKK4/7, and JNK1 to control NPC development during corticogenesis | SIGNOR-271717 |
P19086 | Q9Y5X5 | 2 | binding | up-regulates activity | 0.252 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257104 |
P49810 | P68400 | 0 | phosphorylation | up-regulates activity | 0.307 | In vitro the large hydrophilic loop of PS-2 between transmembrane domains 6 and 7 can be phosphorylated by casein kinase-1 (CK-1) and CK-2, but not by PKA or PKC. Quantitative analysis of in vitro phosphorylation demonstrates the presence of two phosphorylation sites for CK-1 and a single site for CK-2. A deletion anal... | SIGNOR-250934 |
P50613 | P24928 | 1 | phosphorylation | down-regulates | 0.789 | Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subseque... | SIGNOR-120024 |
O15379 | P15976 | 0 | relocalization | up-regulates activity | 0.55 | GATA1 is a new substrate of p21-activated kinase 5 (PAK5), which is phosphorylated on serine 161 and 187 (S161 and S187). GATA1 recruits HDAC3/4 to E-cadherin promoter, which is reduced by GATA1 S161A S187A mutant. These data indicate that phosphorylated GATA1 recruits more HDAC3/4 to promote transcriptional repression... | SIGNOR-275664 |
Q9UH77 | Q96J92 | 2 | binding | down-regulates quantity by destabilization | 0.585 | Here, we found that KLHL3 interacted with Cullin3 and WNK4, induced WNK4 ubiquitination, and reduced the WNK4 protein level. The reduced interaction of KLHL3 and WNK4 by PHAII-causing mutations in either protein reduced the ubiquitination of WNK4, resulting in an increased level of WNK4 protein. | SIGNOR-272105 |
Q5JUK2 | Q68G74 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.486 | Cotransfection of a mouse Sohlh1 expression vector with E box-containing promoter regions of mouse Lhx8, Zp1, and Zp3 fused to luciferase resulted in significant transactivation . Mutation of the E box sequences abolished SOHLH1-dependent stimulation. Thus, Lhx8, Zp1, and Zp3 are likely direct downstream target genes o... | SIGNOR-266076 |
P17661 | P06493 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | In line with this, we found that in Drp/MC mice desmin was hyperphosphorylated in Ser-31 by a hyperactivated Cdk-1. | SIGNOR-278331 |
P36956 | Q8WU17 | 0 | ubiquitination | down-regulates quantity | 0.298 | Induction of TRC8 destabilized the precursor forms of the transcription factors SREBP-1 and SREBP-2. TRC8 destablizes SREBP precursors in a RING and proteasome-dependent manner | SIGNOR-271957 |
P31995 | P07948 | 0 | phosphorylation | up-regulates activity | 0.2 | Fyn and Blk definitely phosphorylate Y-282 in the ITAM of FcgRIIa/c, whereas the non-ITAM tyrosine residue (Y-275) becomes phosphorylated by Syk, as the phosphorylation of double point mutants shows. In addition to these tyrosine residues, Fyn, Blk, and Syk might phosphorylate the most C-terminal tyrosine residue (Y-29... | SIGNOR-262676 |
P49190 | P01270 | 2 | binding | up-regulates | 0.7 | Pth was shown to efficiently activate the human type 2 pth receptor (pth2 receptor) | SIGNOR-115104 |
P21452 | O95837 | 2 | binding | up-regulates activity | 0.433 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257131 |
P17612 | Q9NXR1 | 1 | phosphorylation | up-regulates | 0.4 | Here, we demonstrate that disc1 and pde4 modulate nde1 phosphorylation by camp-dependent protein kinase a (pka) and identify a novel pka substrate site on nde1 at threonine-131 (t131).Since phosphorylated t131 is detectable at multiple subcellular locations (centrosome, nucleus, postsynaptic density, proximal axon), th... | SIGNOR-174410 |
P53350 | Q9BQQ3 | 1 | phosphorylation | down-regulates quantity | 0.729 | As GRASP65 is a substrate of cdc2 and polo-like kinase, manipulation of GRASP65 level may affect the localization and activity of these kinases in cell cycle progression, as suggested by a previous study ( ).|During mitosis, GRASP65 is phosphorylated by two mitotic kinases, cdc2 and polo-like kinase (plk), which leads ... | SIGNOR-279554 |
P24941 | P53350 | 1 | phosphorylation | up-regulates activity | 0.375 | Thus, CycA2-CDK2 can stimulate phosphorylation of PLK1 T210 in vitro and the interactions required for CycA2-mediated PLK1 T210 phosphorylation are detected in the cytoplasm, but not in the nucleus.|We find that Cyclin A2-CDK2 can activate the mitotic kinase PLK1 through phosphorylation of Bora, and that only cytoplasm... | SIGNOR-280212 |
P62820 | Q08379 | 1 | relocalization | up-regulates activity | 0.718 | Here, we demonstrate that the cis ‐Golgi tethering protein GM130, complexed with GRASP65 and other proteins, forms a novel Rab1 effector complex that interacts with activated Rab1‐GTP in a p115‐independent manner and is required for coat protein II vesicle targeting/fusion with the cis ‐Golgi | SIGNOR-261285 |
P12931 | P23467 | 0 | dephosphorylation | down-regulates activity | 0.445 | Collectively, these results suggest that PTPRB inhibits Src activation and down -- regulation of PTPRB activates Src signalling pathway required for cell invasion in A549 cells.|Knockdown of PTPRB increased Src phosphorylation and cell invasion, which was reversed by Src inhibitor PP2. | SIGNOR-277132 |
P10912 | Q13163 | 1 | phosphorylation | up-regulates activity | 0.2 | The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusi... | SIGNOR-255452 |
Q14119 | Q99967 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells | SIGNOR-266883 |
Q8TBB1 | P22459 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.283 | We used the Ligand of Numb protein X (LNX) family of E3s, a group of PDZ domain-containing RING-type E3 ubiquitin ligases, to demonstrate the feasibility of this strategy. Many potential substrates of LNX E3s were identified. Eight of the nine selected candidates were ubiquitinated in vitro, and two novel endogenous su... | SIGNOR-272899 |
Q9UHB9 | O76094 | 2 | binding | up-regulates activity | 0.99 | Taken together our data show that binding of the SRP68/72 heterodimer follows an ultrasensitive response dependent on the SRP72 C-terminus. Although the large solenoids of SRP68/72 have not been structurally characterized due to intrinsic flexibility, they serve as important contact sites in ribosome interaction. | SIGNOR-261164 |
Q99496 | Q6W2J9 | 2 | binding | up-regulates activity | 0.545 | BcoR and Fbxl10/Jhdm1B are among the most abundant Ring1B/Rnf2 interactors identified with the highest confidence, and their association has been validated by coimmunoprecipitation studies; hence we call this the Fbxl10-BcoR complex. In summary, we have widened the set of multiprotein complexes containing the Polycomb... | SIGNOR-252241 |
P04637 | O60729 | 0 | dephosphorylation | down-regulates activity | 0.333 | The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53|. Furthermore, the hCdc14 phosphatases were found to dephosphorylate p53 specifically at the p34Cdc2/clb phosphorylation site (p53-phosphor-Ser315)|Earlier studies showed that Ser315 phosphorylation increases the sequence-sp... | SIGNOR-248332 |
Q16143 | P53350 | 0 | phosphorylation | down-regulates activity | 0.318 | Polo-like kinase (plk) family (plk1, plk2, and plk3) phosphorylate alpha-syn and beta-syn specifically at ser-129 and ser-118, respectively. Polo-like kinase 2 (plk2) phosphorylates alpha-synuclein at serine 129 in central nervous system. The membrane association of pd-linked mutant alpha -synuclein, but not wild-type ... | SIGNOR-176079 |
P50539 | Q9UQE7 | 2 | binding | down-regulates activity | 0.403 | We identified a novel ZIP-containing protein, Mmip1 (Mad member interacting protein 1) that strongly dimerizes with all four Mad members, but not with c-myc. Mmip1 can inhibit DNA binding by Max-Mad heterodimers and, in vivo, can reverse the suppressive eects of Mad proteins on c-myc functions. | SIGNOR-241223 |
O15111 | Q92985 | 1 | phosphorylation | up-regulates | 0.688 | Ikkalfa associated with and phosphorylated and activate interferon regulatory factor-7 (irf7), which is required for interferon-alfa (ifnalfa) production. | SIGNOR-146116 |
P52945 | P13010 | 2 | binding | down-regulates quantity by destabilization | 0.307 | The interaction of PDX-1 with Ku subunits and its phosphorylation on threonine 11 by the DNA-PK appear to be implicated in its degradation by the proteosome. | SIGNOR-225537 |
P01106 | Q92995 | 0 | deubiquitination | up-regulates quantity by stabilization | 0.353 | In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential. USP13 was preferentially expressed in GSCs, and its depletion potently inhibited GSC proliferation and tumor growth by promoting c-Myc ubiq... | SIGNOR-274124 |
P09467 | Q8IYT8 | 0 | phosphorylation | down-regulates activity | 0.2 | Here, we demonstrate that, during deprivation of amino acid and growth factors, ULK1/2 directly phosphorylate key glycolytic enzymes including hexokinase (HK), phosphofructokinase 1 (PFK1), enolase 1 (ENO1), and the gluconeogenic enzyme fructose-1,6-bisphosphatase (FBP1).Phosphorylation of these enzymes leads to enhanc... | SIGNOR-274039 |
P63261 | P29350 | 0 | dephosphorylation | down-regulates | 0.2 | Our data suggest that shp-1 plays a pivotal role in reorganization of cytoskeletal architecture inducing actin dephosphorylation. These results clearly demonstrate the direct interaction of shp-1 with actin | SIGNOR-99565 |
P68400 | P30305 | 1 | phosphorylation | up-regulates activity | 0.338 | Mass spectrometry analysis demonstrates that at least two serine residues, Ser-186 and Ser-187, are phosphorylated in vivo. | Finally, we demonstrate that phosphorylation of CDC25B by protein kinase CK2 increases the catalytic activity of the phosphatase in vitro as well as in vivo. | SIGNOR-250836 |
P07949 | Q8N4X5 | 1 | phosphorylation | up-regulates activity | 0.33 | RET/PTC induced robust tyrosine phosphorylation of XB130, which promoted its subsequent association with the p85alpha subunit of phosphatidylinositol 3-kinase (PI 3-kinase). We identified tyrosine 54 of XB130 as the major target of RET/PTC-mediated phosphorylation and a critical binding site for the SH2 domains of p85a... | SIGNOR-263192 |
Q5JWF2 | P43657 | 2 | binding | up-regulates activity | 0.323 | LPAR1 is reported to associate with Gia,G12/13a,orGqa; LPAR3 with Gia or Gqa; and LPAR6 withGia,G12/13a,orGsa. | SIGNOR-278872 |
P27448 | P11309 | 0 | phosphorylation | down-regulates | 0.418 | Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1. | SIGNOR-128264 |
Q9NR31 | Q9NRC8 | 0 | deacetylation | up-regulates activity | 0.2 | SIRT7 interacts with the helicase DDX21. Deacetylation by SIRT7 is required for DDX21 activity and R-loop unwinding | SIGNOR-260978 |
P57073 | O14965 | 0 | phosphorylation | up-regulates activity | 0.2 | Therefore, Aurora-A not only directly phosphorylates SOX8 but also promotes SOX8 transcription indirectly by regulating c-Myc protein. | SIGNOR-280189 |
Q9NZ42 | Q96BI3 | 2 | binding | up-regulates | 0.962 | Furthermore, overexpression of aph-1 facilitates pen-2-mediated ps1 proteolysis, resulting in a significant increase in ps1 fragments. Our data reveal a direct role of pen-2 in proteolytic cleavage of ps1 and a regulatory function of aph-1, in coordination with pen-2, in the biogenesis of the ps1 complex. | SIGNOR-97104 |
Q8N257 | Q14493 | 0 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265388 |
P40763 | P45984 | 0 | phosphorylation | up-regulates | 0.482 | Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. | SIGNOR-179275 |
Q9BPZ7 | Q02156 | 2 | binding | up-regulates activity | 0.263 | In the present study, we have identified the mTORC2 subunit Sin1 as a direct binding partner of the PKC (protein kinase C) ε kinase domain and map the interaction to the central highly conserved region of Sin1. Exploiting the conformational dependence for PKC phosphorylation, we demonstrate that mTORC2 is essential for... | SIGNOR-276348 |
P55211 | P17612 | 0 | phosphorylation | down-regulates | 0.2 | We show that protein kinase a inhibits activation of caspase-9 and caspase-3 downstream of cytochrome c in xenopus egg extracts and in a human cell-free system. Protein kinase a directly phosphorylates human caspase-9 at serines 99, 183, and 195. | SIGNOR-133884 |
Q6FI13 | Q86Y13 | 0 | monoubiquitination | up-regulates activity | 0.2 | 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TL... | SIGNOR-271755 |
Q14457 | Q9NR19 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes; | SIGNOR-276561 |
P20827 | P29317 | 2 | binding | up-regulates | 0.937 | Ephrin-a1 binds and activates the tyrosine kinase activity of eph-a2, and has a dissociation constant of 20_30 nm | SIGNOR-56901 |
O15554 | Q9NRX4 | 0 | dephosphorylation | down-regulates activity | 0.549 | We now show that the mammalian protein histidine phosphatase (PHPT-1) directly binds and inhibits KCa3.1 by dephosphorylating histidine 358 on KCa3.1.|Overexpression of wild-type, but not a phosphatase dead, PHPT-1 inhibited KCa3.1 channel activity. | SIGNOR-277071 |
Q08999 | O43524 | 0 | transcriptional regulation | up-regulates quantity | 0.291 | Here we show that the Forkheads AFX (FOXO4) and FKHR-L1 (FOXO3a) also directly control transcription of the retinoblastoma-like p130 protein and cause upregulation of p130 protein expression. | SIGNOR-238606 |
P63096 | Q9UKP6 | 2 | binding | up-regulates activity | 0.265 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257051 |
Q8N2Q7 | P58401 | 2 | binding | up-regulates activity | 0.829 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264159 |
P54821 | O60675 | 2 | binding | down-regulates activity | 0.273 | Hoxd12 and MHox, that interact with v-/c-Maf, using the phage display method. The Hox proteins also could associate with the other Maf protein family members, MafB, MafK, MafF, and MafG, but not with Jun and Fos. The Hox proteins negatively regulated the DNA binding, transactivation and cell-transforming abilities of M... | SIGNOR-221932 |
Q7LBC6 | P84243 | 1 | demethylation | down-regulates activity | 0.2 | We have purified a JmjC domain-containing protein, JHDM2A, which specifically demethylates mono- and dimethyl-H3K9. JHDM2A exhibits hormone-dependent recruitment to androgen-receptor target genes, resulting in H3K9 demethylation and transcriptional activation. Thus, our work identifies a histone demethylase and links... | SIGNOR-266636 |
Q9UIJ5 | P24588 | 1 | palmitoylation | up-regulates activity | 0.331 | Here, we report that the recycling endosome-resident palmitoyl acyltransferase DHHC2 interacts with and palmitoylates AKAP79/150 to regulate these plasticity signaling mechanisms | SIGNOR-261289 |
P41236 | P62136 | 2 | binding | down-regulates | 0.785 | Atm phosphorylates i-2 on serine 43, leading to the dissociation of the pp1-i-2 complex and the activation of pp1. | SIGNOR-160651 |
P48454 | O00429 | 1 | dephosphorylation | up-regulates activity | 0.262 | When mitochondrial depolarization is associated with sustained cytosolic Ca(2+) rise, it activates the cytosolic phosphatase calcineurin that normally interacts with Drp1. Calcineurin-dependent dephosphorylation of Drp1, and in particular of its conserved serine 637, regulates its translocation to mitochondria as subst... | SIGNOR-248506 |
Q96GD4 | O96017 | 0 | phosphorylation | up-regulates activity | 0.324 | Because Chk1 and Chk2 can share substrates ( ), we investigated whether Chk2 phosphorylates Aurora B-B-serine 331 in nocodazole.|In addition, Chk2 promotes proper chromosome alignment through Aurora B-B-serine 331 phosphorylation. | SIGNOR-278906 |
P58753 | O60603 | 2 | binding | up-regulates activity | 0.726 | To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TL... | SIGNOR-266745 |
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