IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q16566 | P09429 | 1 | phosphorylation | up-regulates activity | 0.285 | Collectively, our results demonstrate that CaMKIV promotes the nucleocytoplasmic shuttling of HMGB1 and suggest that the process may be mediated through CaMKIV-dependent serine phosphorylation of HMGB1. | SIGNOR-278510 |
Q8N5S9 | Q13131 | 1 | phosphorylation | up-regulates | 0.462 | Ampka1 activators increased phosphorylation level and cytoplasmic localization (reduced nuclear/cytoplasmic ratio). Ampka1 activators reduced rna synthesis in the nucleoli. | SIGNOR-176598 |
O00206 | P05109 | 2 | binding | down-regulates activity | 0.534 | Interestingly, in the present study, we report that extracellular S100A9 induces terminal differentiation of myeloid leukemia cells in human and murine AMLs after TLR4 activation, which is highly expressed by primary myelomonocytic and monocytic leukemia cells. In contrast, anti-S100A8 induced the differentiation of AM... | SIGNOR-261921 |
Q9UBL3 | P23771 | 2 | binding | up-regulates | 0.25 | We identifiedgata3as the binding protein of ash2l. Ash2l was shown to potentiate the transcriptional activity ofgata3. | SIGNOR-205312 |
P40763 | P00533 | 0 | phosphorylation | up-regulates activity | 0.879 | The transcription factors stat1, stat3, and stat5 are directly phosphorylated by erbb-1, subsequent to which they dimerize through phosphotyrosine-sh2 domain interactions and translocate to the nucleus to activate gene trascription critical for proliferation. | SIGNOR-121965 |
Q15596 | P10275 | 2 | binding | up-regulates activity | 0.901 | The NCOA2 gene encodes a transcriptional coactivator (SRC-2) that modulates gene expression by hormone receptors, including AR. NCOA2 is both amplified and rarely mutated in prostate cancers, with higher NCOA2 levels resulting in increased androgen signaling readout. Furthermore, as mentioned previously, SRC-3, a close... | SIGNOR-251531 |
Q05397 | Q06124 | 0 | dephosphorylation | down-regulates | 0.731 | Dca concomitantly and significantly increased association of tyrosine phosphatase shp2 with fak. Incubation of immunoprecipitated fak, in vitro, with glutathione-s-transferase-shp2 fusion protein resulted in tyrosine dephosphorylation of fak in a concentration-dependent manner. | SIGNOR-148926 |
O14511 | P21860 | 2 | binding | up-regulates | 0.82 | Direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3.The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-... | SIGNOR-26881 |
Q8NBZ7 | P29320 | 0 | phosphorylation | up-regulates activity | 0.2 | However, it is possible that etk is a principal activator of Ugd.|The phosphorylation of the Ugd protein (a UDP-glucose dehydrogenase) by Etk increases Ugd dehydrogenase activity. | SIGNOR-280006 |
Q96EV8 | Q86Y07 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | We show that VRK2 phosphorylates Ser 297 and Ser 299 of dysbindin using in vitro kinase assay. In addition, we found that VRK2-mediated phosphorylation of dysbindin enhanced ubiquitination of dysbindin and consequently resulted in the decrease in its protein stability through western blotting. | SIGNOR-277403 |
O14640 | O75581 | 2 | binding | up-regulates activity | 0.707 | The scaffold protein dishevelled (dvl) is required for lrp6 phosphorylation and aggregation. We propose that wnts induce coclustering of receptors and dvl in lrp6-signalosomes, which in turn triggers lrp6 phosphorylation to promote axin recruitment and beta-catenin stabilization. | SIGNOR-156072 |
P24941 | O75469 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.372 | PXR Phosphorylation at S350 by CDK2 Triggers PXR Degradation via the Ubiquitin-Proteasome Pathway. | SIGNOR-279397 |
Q13131 | P17612 | 0 | phosphorylation | down-regulates activity | 0.423 | These agents also enhanced phosphorylation of alpha-Ser(485/491) by the cAMP-dependent protein kinase. AMPK alpha-Ser(485/491) phosphorylation was necessary but not sufficient for inhibition of AMPK activity in response to forskolin/isobutylmethylxanthine. | SIGNOR-256112 |
P46734 | Q9UL54 | 2 | binding | up-regulates activity | 0.67 | Cotransfection experiments suggested that tao2 selectively activates mek3 and mek6 but not meks 1, 4, or 7. | SIGNOR-70947 |
P14784 | P29350 | 0 | dephosphorylation | down-regulates | 0.532 | We have found that il-2 induces association of shp-1 with the il-2 receptor complex, and that once shp-1 is recruited to the activated receptor it is able to decrease tyrosine phosphorylation of il-2rbeta and the associated tyrosine kinases jak1 and jak3. | SIGNOR-55989 |
P24385 | O15379 | 2 | binding | up-regulates | 0.412 | Collectively, these studies suggest an important role of cyclin d1 in regulation of ppargamma-mediated adipocyte differentiation through recruitment of hdacs to regulate ppar response element local chromatin structure and ppargamma function. | SIGNOR-134056 |
P78368 | P07948 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Although there have been more than 40 reports of mass spectrometric studies on phosphorylation at Lyn-S13, the kinase responsible remained unclear. We succeeded in identifying casein kinase 1γ (CK1γ) as the kinase responsible for phosphorylation of Lyn-S13. In HEK293 cells co-expressing Lyn and CK1γ, the phosphorylatio... | SIGNOR-275397 |
P63000 | Q96Q42 | 2 | binding | up-regulates activity | 0.532 | Thus, in our system, activeRac1 may recruit ALS2 only at the very early stage ofmacropinocytosis including membrane ruffles, suggest-ing that ALS2 is retained by some other mechanismsuntil Rab conversion. | SIGNOR-277777 |
Q13535 | Q14191 | 1 | phosphorylation | down-regulates quantity | 0.794 | Importantly, ATR-mediated phosphorylation targets Werner syndrome protein for ubiquitination and degradation.|WRN is phosphorylated at serine 1141 by ATR in response to replication-associated DSBs A. WRN is heavily phosphorylated at S1141 in response to CPT treatment of cells. | SIGNOR-278159 |
P12830 | P53350 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.297 | Priming phosphorylation of Cdh1 by the Cdk2/cyclin A kinase complex allows Plk1 to bind to Cdh1 and phosphorylate Cdh1 at Ser138 and Ser146. Phosphorylation of Cdh1 at Ser138 and Ser146 then triggers its interaction with, and subsequent ubiquitination by, SCFbeta-TRCP | SIGNOR-274054 |
P0C5Z0 | Q14493 | 0 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265407 |
P28482 | Q17RY0 | 1 | phosphorylation | up-regulates activity | 0.325 | Our results indicate that CPEB4 activation is driven by ERK2- and Cdk1 mediated hyperphosphorylation of at least 12 residues in the intrinsically disordered NTD.|We concluded that, in interphase, unphosphorylated CPEB4 phase separates into liquid like droplets that recruit mRNAs but are inactive for cytoplasmic polyade... | SIGNOR-280021 |
P68400 | Q13530 | 1 | phosphorylation | up-regulates activity | 0.2 | The two serines within the PSAC of Serinc3 are phosphorylated by casein kinase II and mediate interaction with the μ subunits in vitro. | SIGNOR-273631 |
O14746 | Q9NY12 | 2 | binding | up-regulates activity | 0.445 | A complex of four proteins (GAR1, NHP2, NOP10, and the putative pseudouridine synthase dyskerin) associates with snoRNAs to form small nucleolar ribonucleoprotein particles (snoRNPs), and the binding of this complex to the H/ACA domain of TERC may have a role in the biogenesis of the telomerase RNP | SIGNOR-263333 |
P46531 | O60684 | 0 | relocalization | up-regulates | 0.2 | Nicd binds via one of its four potential nuclear localization signals to importins alfa3, alfa4, and alfa7. importins alpha3, alpha4 (and to a lesser extent, alpha7) mediate nuclear import of nicd and thus are directly involved in notch signaling. | SIGNOR-165343 |
P07737 | Q13464 | 0 | phosphorylation | down-regulates | 0.272 | We previously identified pfn1 as a huntingtin aggregation inhibitor, and others have implicated it as a tumor-suppressor. Rho-associated kinase (rock) directly phosphorylates pfn1 at ser-137 to prevent its binding to polyproline sequences. This negatively regulates its anti-aggregation activity. | SIGNOR-196820 |
O14874 | P53396 | 1 | phosphorylation | up-regulates activity | 0.2 | BCKDK can activate ACLY and promote the cleavage of citric acid into acetyl-CoA, and oxaloacetate.|BCKDK can phosphorylate BCKDHA and ATP citrate lyase (ACLY), exerting opposing effects on both. | SIGNOR-280194 |
P30304 | O14757 | 0 | phosphorylation | down-regulates | 0.857 | The signal for ubiquitination after uv and ir exposure is created by phosphorylation of cdc25a mediated by chk1 and chk2, respectively. Chk1 is a major kinase phosphorylating cdc25a (ser76/124) and cdc25c (ser216). | SIGNOR-163134 |
P04049 | P67775 | 0 | dephosphorylation | up-regulates | 0.592 | Both pp2a holoenzymes were found to associate with raf1 and catalyze dephosphorylation of inhibitory phospho-ser-259. Together these findings indicate that pp2a abalphac and abdeltac holoenzymes function as positive regulators of raf1-mek1/2-erk1/2 signaling by targeting raf1. | SIGNOR-141170 |
P36897 | O43541 | 2 | binding | down-regulates activity | 0.74 | The inhibitory Smads (I-Smads), i.e. Smad6 and Smad7, are negative regulators of transforming growth factor-_ (TGF-_) family signaling. I-Smads inhibit TGF-_ family signaling principally through physical interaction with type I receptors (activin receptor-like kinases), so as to compete with receptor-regulated Smads (R... | SIGNOR-167160 |
Q99856 | P0DOX6 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | In this work, we show that TFII-I directly interacts with human Bright through amino acids in Bright's protein interaction domain and that specific tyrosine residues of TFII-I are essential for Bright-induced activity of an immunoglobulin reporter gene. Moreover, inhibition of TFII-I function in a B-cell line resulted ... | SIGNOR-268532 |
P62714 | Q05655 | 1 | dephosphorylation | down-regulates activity | 0.3 | PP2A(c) displayed the highest specific activity towards PKCdelta. The role of PP2A(c) in the dephosphorylation of PKCdelta in cells was supported by the demonstration that these proteins could be co-immunoprecipitated from NIH3T3 cells.|In conclusion, the evidence here indicates that PKCdelta de-phosphorylation and hen... | SIGNOR-248595 |
Q15643 | P61019 | 2 | binding | up-regulates activity | 0.394 | Vesicle-associated Rab2 then mediates attachment to the Rab2 binding site within the central coiled-coil region of GMAP-210, bringing the vesicle into closer proximity to the target membrane. GMAP-210 function in vivo is dependent upon its ability to tether membranes, which is mediated exclusively by the amino-terminal... | SIGNOR-261300 |
P28482 | Q9BY84 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.808 | Phosphorylation of Ser-446 determines stability of MKP-7.|We also determined that MKP-7 phosphorylated at Ser-446 has a longer half-life than unphosphorylated form of the wild type protein, as does a phospho-mimic mutant of MKP-7. These results indicate that activation of the ERK pathway strongly blocks JNK activation ... | SIGNOR-249389 |
Q13131 | P98177 | 1 | phosphorylation | up-regulates | 0.371 | The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt phosphorylation sites, resulting in foxo activation | SIGNOR-157947 |
P25098 | Q14940 | 1 | phosphorylation | down-regulates activity | 0.2 | Simultaneous mutation of five Ser/Thr residues within 702-714 to Ala ((702)ST/AA(714)) abolished phosphorylation and binding of beta-arrestin2. In transfected cells, the CK2 catalytic alpha subunit formed a complex with NHE5 and decreased wild-type but not (702)ST/AA(714) NHE5 activity, further supporting a regulatory ... | SIGNOR-275503 |
Q9UQD0 | Q13555 | 0 | phosphorylation | up-regulates activity | 0.271 | CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. | SIGNOR-275794 |
O00192 | P19022 | 2 | binding | up-regulates quantity by stabilization | 0.466 | To clarify the role of p120 in mammalian cells, we have knocked down p120 with siRNA in cells expressing epithelial (E-), placental (P-), neuronal (N-), and vascular endothelial (VE-) cadherins. We report that each of these cadherins, as well as α- and β-catenins, were rapidly degraded in the absence of p120, resulting... | SIGNOR-252128 |
P21802 | P21802 | 2 | phosphorylation | up-regulates activity | 0.2 | Our data also show that tyrosine 769 is not involved in the regulation of the endocytic process of KGFR.Following ligand binding, KGFR is rapidly autophosphorylated on specific tyrosine residues | SIGNOR-276026 |
P18031 | P29597 | 1 | dephosphorylation | down-regulates activity | 0.646 | Upon ligand binding, IL-2R , IL-6R or LeptinR , IFN-_R , IFN-_R and PRLR or growth hormone (GH) receptor associated JAKs become activated. These JAKs mediate phosphorylation of specific tyrosine residues and recruit STATs. Activated STATs are released from the receptor and translocate to the nucleus. PTP1B dephosphory... | SIGNOR-134564 |
O00213 | P00519 | 0 | phosphorylation | up-regulates | 0.415 | The c-abl tyrosine kinase phosphorylates the fe65 adaptor protein to stimulate fe65/amyloid precursor protein nuclear signaling. Here, we show that active c-abl stimulates app/fe65-mediated gene transcription and that this effect is mediated by phosphorylation of fe65 on tyrosine 547 within its second ptb domain. | SIGNOR-123476 |
O15194 | P06400 | 1 | dephosphorylation | up-regulates activity | 0.298 | ppRB (RB phosphorylated at Ser-807/811|Possible Mechanisms of HYA22 Action in Tumorigenesis: Dephosphorylation of RB by Transient Expression of HYA22 Isoforms. | SIGNOR-248304 |
P38405 | Q08828 | 2 | binding | up-regulates activity | 0.539 | D1-class dopamine receptors (D1 and D5) activate the G s/olf family of G proteins to stimulate cAMP produc tion by AC and are found exclusively postsynaptically on dopamine-receptive cells, such as GABA-ergic medium spiny neurons (MSNs) in the striatum. | SIGNOR-264992 |
P52797 | P29322 | 2 | binding | up-regulates | 0.75 | Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). I... | SIGNOR-52387 |
P28062 | Q07820 | 1 | null | down-regulates quantity by destabilization | 0.2 | Surprisingly, siRNA knockdown of PSMB8 (LMP7), an ‘immunoproteasome’ component, reversed IFNγ-induced sensitivity to Fas ligation and prevented Fas/IFNγ-induced degradation of Mcl-1, but did not protect p-Bcl-2 or p-Bcl-XL. Proteasome inhibition markedly increased Mcl-1, p-Bcl-2, and p-Bcl-XL levels after IFNγ treatmen... | SIGNOR-261974 |
P35221 | Q06124 | 0 | dephosphorylation | down-regulates | 0.435 | Tyr148 of beta-catenin is an shp2 target dephosphorylation site. Together, these results suggest that beta-catenin plays a suppressor role in cell transformation and that shp2, by dephosphorylating beta-catenin, promotes mitogenic, cell survival and transformation signals. | SIGNOR-147075 |
P61981 | Q9NRM7 | 0 | phosphorylation | up-regulates | 0.331 | Phosphorylation of 14-3-3_ on s59 by lats2. Ser(58) phosphorylation and lys(49) acetylation of 14-3-3_ occur in a coordinated time-dependent manner to regulate 14-3-3_ homodimerization. 14-3-3_ ser(58) phosphorylation is required for star interactions under control conditions, | SIGNOR-205247 |
P46060 | P06493 | 0 | phosphorylation | up-regulates | 0.495 | Here, we show that rangap1 is phosphorylated on residues t409, s428, and s442. Phosphorylation occurs before nuclear envelope breakdown and is maintained throughout mitosis . Alternatively, phosphorylated rangap1 may recruit specific sumo target proteins to ranbp2's catalytic domain. | SIGNOR-123520 |
Q8WYK2 | P15336 | 2 | binding | down-regulates activity | 0.557 | JDP2 dimerizes with other AP-1 proteins such as activating transcription factor-2 (ATF2) and Jun to repress transcription from promoters that contain a cyclic AMP-responsive element (CRE). | SIGNOR-226395 |
Q99558 | P40763 | 1 | phosphorylation | up-regulates activity | 0.26 | Activation of Stat3 by NIK requires NIK kinase activity as showed by kinase assays.|When we transfected NIK into LNCaP cells, NIK was able to phosphorylate Stat3 at both tyrosine 705 and serine 727 residues ( Fig. 3 A). | SIGNOR-279341 |
O95180 | Q9UQM7 | 0 | phosphorylation | down-regulates activity | 0.272 | we also discovered that a novel CaMKII-phosphorylated site, S2137, underwent dephosphorylation by calcineurin. | SIGNOR-277871 |
P40763 | Q06187 | 0 | phosphorylation | down-regulates activity | 0.382 | Phosphorylation of STAT-3 by BTK may also alter the conformation of STAT-3 in such a way as to make it inaccessible as a substrate of activating kinases such as JAK3.|The ability of BTK to negatively regulate STAT-3 activity suggests several possible models for a mechanism of BTK action. | SIGNOR-279011 |
P50222 | O60315 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.318 | ZEB2 represses GAX transcription through multiple up- stream consensus binding sites. | SIGNOR-268951 |
P14618 | Q00534 | 0 | phosphorylation | down-regulates activity | 0.259 | Here, using human cancer cells and patient-derived xenografts in mice, we show that the cyclin D3-CDK6 kinase phosphorylates and inhibits the catalytic activity of two key enzymes in the glycolytic pathway, 6-phosphofructokinase and pyruvate kinase M2. | SIGNOR-279158 |
P46531 | O00629 | 0 | relocalization | up-regulates | 0.287 | Nicd binds via one of its four potential nuclear localization signals to importins alfa3, alfa4, and alfa7. | SIGNOR-165314 |
O00308 | O15350 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.283 | WWP2 ubiquitinates p73 and controls its protein stability. In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. | SIGNOR-272233 |
Q04721 | Q92585 | 2 | binding | up-regulates | 0.808 | Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes1. | SIGNOR-84835 |
Q9NQ66 | P29992 | 2 | binding | up-regulates | 0.623 | Plc-_1 stimulates hydrolysis of gq/11-bound gtp and acts as a gtpase-activating protein (gap) for its physiologic regulator, gq/11 | SIGNOR-17239 |
P31749 | P46527 | 1 | phosphorylation | down-regulates | 0.85 | Because Thr198-phosphorylated p27Kip1 was localized only in the cytoplasm, Akt might promote 14-3-3 binding to p27Kip1 by phosphorylation at Thr198, allowing its cytoplasmic localization and degradation. | SIGNOR-88294 |
P01375 | O75509 | 2 | binding | up-regulates | 0.337 | We report the identification and initial characterization of dr6, a new member of the tnf receptor family possessing a cytoplasmic death domain. | SIGNOR-59745 |
Q92905 | Q9NZQ7 | 1 | deubiquitination | up-regulates quantity by stabilization | 0.2 | The results suggested that TNF-α upregulates expression of CSN5, which interacts and deubiquitinates PD-L1 for protein stabilization. | SIGNOR-274977 |
O15297 | Q9NR19 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes; | SIGNOR-276560 |
Q9HAZ2 | P12755 | 2 | binding | up-regulates | 0.326 | Biochemical analysis demonstrated that mel1 interacts with ski and inhibits tgf-_ signaling by stabilizing the inactive smad3-ski complex on the promoter of tgf-_ target genes. | SIGNOR-182529 |
P23470 | P09619 | 1 | dephosphorylation | down-regulates activity | 0.338 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254715 |
P46934 | Q00987 | 1 | ubiquitination | up-regulates quantity by stabilization | 0.466 | NEDD4 promotes MDM2 ubiquitination in a dose- and time-dependent manner, whereas depletion of NEDD4 reduced the half-life of endogenous MDM2 [ xref ]. | SIGNOR-278769 |
P53350 | O43474 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.249 | We further found that inhibition of polo-like kinase 1 could downregulate the expression of KLF4 and that PLK1 directly phosphorylated KLF4 at Ser234. Notably, phosphorylation of KLF4 by PLK1 caused the recruitment and binding of the E3 ligase TRAF6, which resulted in KLF4 K32 K63-linked ubiquitination and stabilizatio... | SIGNOR-277463 |
O75581 | O14904 | 2 | binding | up-regulates | 0.64 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-132076 |
P04233 | P61073 | 2 | binding | up-regulates | 0.531 | Cd74 forms functional complexes with cxcr4 that mediate mif-specific signaling. | SIGNOR-187461 |
P17252 | P05204 | 1 | phosphorylation | down-regulates | 0.29 | Protein kinases that phosphorylate hmg-14 17 at the major sites have been implicated from previous in vitro studies. Protein kinase c and a similar calcium phospholipid-dependent kinase have been reported to phosphorylate both proteins in vitro, where the phosphorylation of hmg-17 occurs predominantly at ser24 and to a... | SIGNOR-76320 |
Q9HBH9 | P27361 | 0 | phosphorylation | up-regulates | 0.517 | Erk and p38 phosphorylate mnk1 and mnk2, which stimulates their in vitro kinase activity. | SIGNOR-48355 |
P49840 | P10636 | 1 | phosphorylation | down-regulates | 0.429 | Tau is phosphorylated by gsk-3 at several sites found in alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by a-kinase. | SIGNOR-60651 |
P53667 | O14965 | 2 | phosphorylation | up-regulates activity | 0.262 | Here, we report a novel functional cooperativity between Aur-A and LIMK1 through mutual phosphorylation. LIMK1 is recruited to the centrosomes during early prophase and then to the spindle poles, where it colocalizes with Aur-A. Aur-A physically associates with LIMK1 and activates it through phosphorylation, which is i... | SIGNOR-276400 |
P06241 | Q14524 | 1 | phosphorylation | down-regulates | 0.293 | This study addresses the effects of the src family tyrosine kinase fyn on na(v)1.5 cardiac sodium channels. Sodium currents were acquired by whole cell recording on hek-293 cells transiently expressing na(v)1.5. Acute treatment of cells with insulin caused a depolarizing shift in steady-state inactivation, an effect el... | SIGNOR-135600 |
A7MCY6 | Q9BWT7 | 1 | relocalization | up-regulates activity | 0.2 | TBKBP1 recruits TBK1 to protein kinase C-theta (PKCθ) through a scaffold protein, CARD10. This enables PKCθ to phosphorylate TBK1 at Ser 716, a crucial step for TBK1 activation | SIGNOR-272470 |
Q15722 | P09471 | 2 | binding | up-regulates activity | 0.265 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256970 |
P00533 | P22681 | 2 | relocalization | up-regulates | 0.886 | Likewise, cbl is recruited to erbb1 either directly (tyr1045), or indirectly, trough grb2 | SIGNOR-147826 |
Q06124 | P01111 | 1 | dephosphorylation | up-regulates activity | 0.673 | Here we identify SHP2 as the ubiquitously expressed tyrosine phosphatase that preferentially binds to and dephosphorylates Ras to increase its association with Raf and activate downstream proliferative Ras/ERK/MAPK signalling. | SIGNOR-255754 |
P78527 | Q13535 | 0 | phosphorylation | up-regulates | 0.31 | Finally, in vitro atr-mediated phosphorylation at the t2609 cluster was further confirmed by western blot analysis using phosphospecific antibodies against t2647 (fig. ?(Fig.7e),7e), suggesting that dna-pkcs could be the direct target of atr kinase. | SIGNOR-148722 |
Q13233 | O14920 | 1 | phosphorylation | up-regulates activity | 0.595 | These results suggested that IKK\u03b2 was a likely substrate for MEKK1 and that MEKK1 phosphorylation of IKK\u03b2 increased its kinase activity. | SIGNOR-279339 |
P09429 | P31277 | 2 | binding | up-regulates activity | 0.292 | We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection ... | SIGNOR-240559 |
P35226 | Q14157 | 2 | binding | up-regulates activity | 0.514 | We identified UBAP2L as a novel BMI1-interacting protein. UBAP2L, BMI1, RNF2, and PHC1 define a novel Polycomb subcomplex | SIGNOR-261315 |
Q9BRS8 | P42345 | 0 | phosphorylation | up-regulates activity | 0.2 | Binding of La ribonucleoprotein domain family, member 6 (LARP6) to collagen mRNAs regulates their translation and is necessary for high type I collagen expression. Here we show that mTORC1 phosphorylates LARP6 on S348 and S409. The S348A/S409A mutant of LARP6 acts as a dominant negative protein in collagen biosynthesis... | SIGNOR-273679 |
P35241 | Q9H270 | 2 | binding | up-regulates activity | 0.347 | Vps11 was found to interact with radixin. ERM proteins and the HOPS complex are required for the transition from early to late endosomes. We report that an interaction between subunits of the HOPS complex and the ERM (ezrin, radixin, moesin) proteins is required for the delivery of EGF receptor (EGFR) to lysosomes. Inh... | SIGNOR-261312 |
Q9BW92 | Q2TAL8 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269407 |
P61586 | Q9NZN5 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.905 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260539 |
O15264 | O00418 | 1 | phosphorylation | down-regulates activity | 0.578 | eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. eEF2K[S359A] was phosphorylated (presumably at Ser396) by the high concentrations of SAPK4/p38 used in this experiment. However, the inhibition of eEF2K under these conditions was reduced from 82% in the wild-type enzyme to 19% in eEF2K[S359A] | SIGNOR-250089 |
Q9Y5H7 | P05556 | 2 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. | SIGNOR-265669 |
P13591 | P39905 | 2 | binding | up-regulates activity | 0.7 | Recently, NCAM was identified as an alternative receptor for GDNF. These new results may explain the findings that, in several regions, the GDNF receptor (GFRa1) is highly expressed, while RET is undetectable. | SIGNOR-252189 |
A6NFN3 | O00712 | 0 | transcriptional regulation | up-regulates quantity | 0.2 | For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) | SIGNOR-268912 |
P49768 | P55212 | 0 | cleavage | up-regulates activity | 0.372 | Remarkably, the caspases acting on PS1 could be subdivided in two groups. One group, containing caspase-8, -6 and -11, cleaved PS1 after residues ENDD329 and to a lesser extent after residues AQRD341. A second group consisting of caspase-3, -7 and -1 acted uniquely on AQRD341. Importantly, these two cleavage sites were... | SIGNOR-261753 |
P48454 | Q6VAB6 | 1 | dephosphorylation | up-regulates activity | 0.259 | These findings indicate that calcineurin modulates the phosphorylation state of KSR2, but not KSR1, and identifies S198, T287, and the S310 14-3-3 binding site as the KSR2 residues targeted by calcineurin.|the negative regulators 14-3-3 | SIGNOR-248527 |
P32239 | P08754 | 2 | binding | up-regulates activity | 0.267 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257150 |
P39905 | P13591 | 2 | binding | up-regulates activity | 0.7 | Recently, NCAM was identified as an alternative receptor for GDNF. These new results may explain the findings that, in several regions, the GDNF receptor (GFRa1) is highly expressed, while RET is undetectable. | SIGNOR-252189 |
P24941 | Q03112 | 1 | phosphorylation | up-regulates activity | 0.296 | The motif harbouring S436 is a target of CDK2 and CDK3 kinases, which interacted with EVI1-WT. The methyltransferase DNMT3A bound preferentially to EVI1-WT compared with EVI1-S436A, and a hypomethylated cell population associated by EVI1-WT expression in murine haematopoietic progenitors is not maintained with EVI1-S43... | SIGNOR-273426 |
Q05655 | Q9BZK7 | 1 | phosphorylation | up-regulates activity | 0.2 | In addition, we describe that the functions and the specificity of these two highly- related exchange factors is tightly regulated by signal-induced phosphorylation events at the level of target gene promoters, as exemplified by the role of TBLR1 phosphorylation at Ser 123 by PKCδ upon retinoic acid or estrogen stimula... | SIGNOR-260903 |
Q92985 | P51617 | 0 | phosphorylation | up-regulates activity | 0.792 | These data indicate that IRAK-1, but not IRAK-4, phosphorylates IRF7 in vitro. | SIGNOR-278235 |
Q9Y478 | P29474 | 1 | phosphorylation | up-regulates | 0.2 | Recently many investigators have shown that protein phosphorylation of enos by several serine/threonine kinases is a critical control step for no production by endothelial cells. Phosphorylation by amp kinase, akt (or protein kinase b), or protein kinase a on serine 1179 (bovine) or serine 1177 (human) of enos leads to... | SIGNOR-112367 |
P14210 | O15393 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | we identified pro-hepatocyte growth factor (HGF) as a TMPRSS2 substrate and confirmed that HGF and it’s cognate receptor c-Met are activated in prostate cancers expressing TMPRSS2, a finding that also associated with the acquisition of a pro-invasive mesenchymal gene expression program. | SIGNOR-263657 |
Q03113 | P30872 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256958 |
P04637 | Q9NQ88 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces glycolysis and is highly expressed in carcinoma cells in the majority of human breast cancers. TIGAR is the only known phosphatase glycolytic modulator regulated by TP53. The current study delineates the role of TIGAR in OXPHOS a... | SIGNOR-267365 |
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