IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q8TEM1 | P06493 | 0 | phosphorylation | up-regulates activity | 0.549 | In vitro phosphorylation of GST fusion protein containing the carboxyl-terminal domain of gp210 by cyclin B-p34cdc2 protein kinase generates a phosphopeptide that comigrates with a mitosis-specific phosphopeptide. Ser1880 Is the Mitotic Phosphorylation Site of Gp210. | SIGNOR-262699 |
P37288 | P50148 | 2 | binding | up-regulates activity | 0.463 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257077 |
P17612 | P17542 | 1 | phosphorylation | down-regulates | 0.2 | Thus, our data revealed a novel interplay between pka phosphorylation and tal1-mediated epigenetic regulation that regulates hematopoietic transcription and differentiation programs during hematopoiesis and leukemogenesis. | SIGNOR-195987 |
P10275 | Q5VUA4 | 2 | binding | down-regulates activity | 0.372 | Using different promoters and cells, we confirmed that AR-mediated transactivation was repressed by TZF in a dose-dependent manner (Fig. 1A and B). Endogenous ARmediated transactivation was also inhibited by expression of TZF; These results indicate that amino acid residues 512–663 are essential for the repressive effe... | SIGNOR-261187 |
Q16828 | P27361 | 2 | dephosphorylation | down-regulates | 0.855 | P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). | SIGNOR-103149 |
P09471 | P21917 | 2 | binding | up-regulates activity | 0.46 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256982 |
P05067 | P78536 | 0 | cleavage | up-regulates activity | 0.539 | By the use of gene disruption (knockout), we now demonstrate that TACE (tumor necrosis factor alpha converting enzyme), a member of the ADAM family (a disintegrin and metalloprotease-family) of proteases, plays a central role in regulated alpha-cleavage of APP. Our data suggest that TACE may be the alpha-secretase resp... | SIGNOR-262829 |
P06401 | P27361 | 0 | phosphorylation | down-regulates | 0.561 | Specifically, down-regulation of mature prs occurs by a mechanism in which ligand binding activates pr phosphorylation by mapks at a unique serine residue, which then targets the receptors for degradation. | SIGNOR-74716 |
Q13489 | Q13546 | 1 | polyubiquitination | up-regulates activity | 0.747 | CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation. | SIGNOR-272713 |
Q9Y570 | P67775 | 1 | demethylation | down-regulates activity | 0.905 | Methylation of the carboxy-terminal Leu309 in a conserved TPDYFL309 motif of the C subunit has been shown to enhance the affinity of the PP2A core enzyme for some, but not all, regulatory subunits |Demethylation and negative regulation of PP2A is mediated by a PP2A-specific methylesterase PME-1, which is conserved from... | SIGNOR-265748 |
P14174 | P61073 | 2 | binding | up-regulates activity | 0.371 | We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF [] By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. | SIGNOR-252062 |
P42336 | P21860 | 2 | binding | up-regulates | 0.708 | Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. | SIGNOR-146861 |
Q86Y01 | P50553 | 2 | binding | down-regulates | 0.261 | Through its binding to p300, dtx1 inhibited transcriptional activation by the neural-specific helix-loop-helix-type transcription factor mash1 | SIGNOR-110626 |
Q16649 | Q16649 | 2 | binding | up-regulates activity | 0.2 | E4BP4, ATF-6, OASIS, and XBP-1 all formed strong homodimeric associations on the array Transcription factor dimerization can increase the selectivity of protein-DNA interactions and generate a large amount of DNA binding diversity from a relatively small number of proteins | SIGNOR-224248 |
P12004 | P49459 | 0 | ubiquitination | up-regulates | 0.476 | Pcna is mono-ubiquitinated through rad6 and rad18, modified by lysine-63-linked multi-ubiquitination--which additionally requires mms2, ubc13 and rad5--and is conjugated to sumo by ubc9. The first of these is monoubiquitination of lysine 164 on one or more of the pcna subunits by the e2-e3 complex of rad6-rad18. | SIGNOR-92737 |
O95071 | Q9BPZ3 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.445 | We demonstrate a mechanism for this co-regulation that involves an E3 ubiquitin ligase, EDD, which targets Paip2 for degradation. PABP depletion by RNA interference (RNAi) causes co-depletion of Paip2 protein without affecting Paip2 mRNA levels. Upon PABP knockdown, Paip2 interacts with EDD, which leads to Paip2 ubiqui... | SIGNOR-272648 |
Q13535 | O96017 | 1 | phosphorylation | up-regulates activity | 0.86 | Atm- and rad3-related also phosphorylates thr68 in addition to thr26 and ser50, which are not phosphorylated to a significant extent by atm in vitro.Substitution of thr68 with ala reduced the extent of phosphorylation and activation of chk2 in response to ir | SIGNOR-81442 |
P60842 | Q15056 | 2 | binding | up-regulates activity | 0.802 | Either eIF4B or eIF4H stimulated the initial rate and amplitude of eIF4A-dependent duplex unwinding, and the magnitude of stimulation is dependent on duplex stability | SIGNOR-261294 |
P54619 | P78527 | 0 | phosphorylation | up-regulates activity | 0.2 | PRKDC interacted with the AMPK complex and phosphorylated its nucleotide-sensing γ1 subunit PRKAG1/AMPKγ1 at Ser192 and Thr284, both events being significantly reduced upon the activation of the AMPK complex. Alanine substitutions of PRKDC phosphorylation sites in PRKAG1 reduced AMPK complex activation without affectin... | SIGNOR-277503 |
P08670 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.27 | Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils. | SIGNOR-278922 |
Q9Y4K3 | Q99538 | 1 | polyubiquitination | up-regulates quantity by stabilization | 0.307 | We demonstrate that TRAF6 ubiquitinates the proform of AEP through K63-linked polyubiquitin, reversible by USP17, and forms a complex with HSP90α to subsequently promote pro-AEP intracellular stability as well as secretion. We now present evidence that AEP is a substrate for TRAF6 ubiquitination, resulting in AEP/TRAF6... | SIGNOR-272853 |
Q9UNE7 | P54253 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.441 | CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation|Interestingly, CHIP also interacts with and ubiquitinates unexpanded ataxin-1 | SIGNOR-278666 |
P24941 | P25098 | 1 | phosphorylation | down-regulates | 0.2 | We report that grk2 protein levels are transiently down-regulated during the g2/m transition by a mechanism involving cdk2-mediated phosphorylation of grk2 at serine670, which triggers binding to the prolyl-isomerase pin1 and subsequent degradation. | SIGNOR-163279 |
Q92847 | P63096 | 2 | binding | up-regulates activity | 0.373 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257054 |
O15264 | Q12888 | 1 | phosphorylation | down-regulates activity | 0.2 | Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif.|Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks |phosphorylation of T1609 is likely to be mediated by p38 MAPK | SIGNOR-264449 |
P02649 | Q05519 | 0 | post transcriptional regulation | up-regulates quantity by stabilization | 0.2 | We demonstrate that SFRS11 directly binds to the 3' UTR of LRP8 mRNA, as well as to the third exon of apoE mRNA, resulting in stabilization of these mRNAs, eventually deactivating JNK signaling. | SIGNOR-269671 |
Q13535 | P78527 | 1 | phosphorylation | up-regulates | 0.31 | Finally, in vitro atr-mediated phosphorylation at the t2609 cluster was further confirmed by western blot analysis using phosphospecific antibodies against t2647 (fig. ?(Fig.7e),7e), suggesting that dna-pkcs could be the direct target of atr kinase. | SIGNOR-148722 |
Q00535 | Q05193 | 1 | phosphorylation | up-regulates activity | 0.516 | Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates dynamin I on Ser 774 and Ser 778 in vitro, which are identical to its endogenous phosphorylation sites in vivo. Cdk5 antagonists and expression of dominant-negative Cdk5 block phosphorylation of dynamin I, but not of amphiphysin or AP180, in nerve termi... | SIGNOR-250661 |
Q9C0F0 | P45973 | 2 | binding | down-regulates activity | 0.251 | Here, we showed that ASXL3 interacts with HP1α and LSD1, leading to transcriptional repression. | SIGNOR-266763 |
Q92547 | Q8WXE1 | 2 | binding | up-regulates | 0.796 | Topbp1 directly activates atr/atrip and promotes atr-mediated chk1 phosphorylation. | SIGNOR-163214 |
P12830 | P56524 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.287 | GATA1 is a new substrate of p21-activated kinase 5 (PAK5), which is phosphorylated on serine 161 and 187 (S161 and S187). GATA1 recruits HDAC3/4 to E-cadherin promoter, which is reduced by GATA1 S161A S187A mutant. These data indicate that phosphorylated GATA1 recruits more HDAC3/4 to promote transcriptional repression... | SIGNOR-275663 |
P48050 | P00533 | 0 | phosphorylation | up-regulates activity | 0.2 | These results demonstrate that the EGF receptor tyrosine kinase up-regulates the K(IR) 2.3 channel via phosphorylation of the Y234 residue of the WT protein. | SIGNOR-276322 |
P68400 | P54274 | 1 | phosphorylation | up-regulates | 0.2 | Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation. Mapping of the ck2 target site identified threonine 122 as a substrate in trf1. A threonine to alanine change at this position led to a diminished dna binding due to reduced dimerization of trf1. | SIGNOR-178034 |
P08754 | P25021 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257162 |
Q05655 | P48048 | 1 | null | up-regulates activity | 0.307 | To determine whether this channel is a substrate for PKA, ROMK tagged with the hemagglutinin epitope was transiently transfected into HEK293 cells. In vitro labeling of immunoprecipitated proteins from transfected cells showed that ROMK could be phosphorylated by PKA. | Taken together, these results provide strong evid... | SIGNOR-248943 |
O43306 | P63096 | 2 | binding | down-regulates activity | 0.541 | Types V and VI adenylyl cyclase are most sensitive to inhibition by Gnai1, Gnai2, and Gnai3 | SIGNOR-278077 |
O43921 | Q15375 | 2 | binding | up-regulates | 0.806 | The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion. | SIGNOR-52206 |
P09629 | P68400 | 0 | phosphorylation | down-regulates activity | 0.344 | Thus, we concluded that CKII can phosphorylate HOXB7 in vitro and that this phosphorylation occurs at both of the CKII target sites, S133 and T204. | Wild-type HOXB7 inhibited the differentiation of 32D cells, whereas mutations in the Pbx-binding pentapeptide motif or the DNA-binding homeodomain, as well as internal de... | SIGNOR-250896 |
O15259 | P68400 | 0 | phosphorylation | up-regulates | 0.2 | Casein kinase 2 (ck2)-mediated phosphorylation of three critical serine residues within a cluster of acidic amino acids in nephrocystin mediates pacs-1 binding, and is essential for colocalization of nephrocystin with pacs-1 at the base of cilia. Inhibition of ck2 activity abrogates this interaction and results in the ... | SIGNOR-142343 |
Q13045 | Q96BR1 | 0 | phosphorylation | up-regulates | 0.355 | Here we show that flii is an in vivo substrate of cisk that functions downstream of pi 3-kinase. Cisk can associate with flii and phosphorylate flii at residues ser(436) and thr(818).We demonstrate here that cisk can enhance er transcription, which is dependent on its kinase activity, and mutation of cisk phosphorylati... | SIGNOR-184688 |
P98160 | Q13332 | 2 | binding | up-regulates | 0.253 | We demonstrate here that cptpsigma is a heparin-binding protein and that its basal lamina ligands include the heparan sulfate proteoglycans (hspgs) agrin and collagen xviii. | SIGNOR-115246 |
Q15022 | P19784 | 0 | phosphorylation | up-regulates activity | 0.2 | CK2 is the kinase for the phosphorylation of S583 of SUZ12. | SIGNOR-277797 |
P84022 | Q8N2W9 | 2 | binding | down-regulates | 0.648 | Piasy binds most strongly with smad3 and also associates with other receptor-regulated smads and smad4. smad3, smad4, and piasy can form a ternary complex. Piasy does not inhibit smad complex binding to dna, but it represses smad transcriptional activity. | SIGNOR-104538 |
P12931 | P53801 | 1 | phosphorylation | up-regulates activity | 0.2 | Src induction leads to phosphorylation at PBF residue Y174. Abrogation of this residue results in PM retention and a markedly reduced ability to bind NIS. | SIGNOR-273810 |
Q8N3J5 | P12694 | 1 | dephosphorylation | up-regulates activity | 0.783 | BCKD is inhibited by phosphorylation of its E1alpha subunit at Ser293, which is catalyzed by BCKD kinase. During BCAA excess, phosphorylated Ser293 (pSer293) becomes dephosphorylated through the concerted inhibition of BCKD kinase and the activity of an unknown intramitochondrial phosphatase. Using unbiased, proteomic ... | SIGNOR-248758 |
P16471 | P01236 | 2 | binding | up-regulates | 0.924 | Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor (prlr). | SIGNOR-72810 |
O95863 | Q13153 | 0 | phosphorylation | up-regulates | 0.4 | Pak1 regulates the repressor activity of snail by phosphorylating on ser(246). Pak1 phosphorylation of snail supports snail's accumulation in the nucleus as well as its repressor functions. | SIGNOR-135605 |
Q06124 | O95297 | 1 | dephosphorylation | down-regulates | 0.522 | In vitro, tyrosine-phosphorylated pzr was efficiently dephosphorylated by the full-length form of shp-2 but not by its sh2 domain-truncated form. The coexisting binding and dephosphorylation of pzr by shp-2 may function to terminate signal transduction initiated by pzr and shp-2 and to set a threshold for the signal tr... | SIGNOR-75220 |
O14980 | P62826 | 2 | binding | up-regulates activity | 0.928 | The nuclear export by CRM1 requires an interaction with the small GTPase Ras-related nuclear antigen (Ran), which cycles between GTP- and GDP-bound states. The binding of Ran GTP to CRM1 in the nucleus increases the affinity of CRM1 for cargo proteins | SIGNOR-275848 |
Q14493 | P0C0S8 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265403 |
P40763 | P01189 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.638 | We show that phospho-STAT3 activates POMC promoter in response to leptin signaling through a mechanism that requires an SP1-binding site in the POMC promoter. | SIGNOR-263497 |
Q96N16 | P07437 | 2 | binding | up-regulates quantity by stabilization | 0.2 | In Jamip1, the N-terminal region mediates the association with microtubules, when highly expressed, N-ter drastically affects the organization of microtubules that appear to be bundled, stabilized against the depolymerizing effect of nocodazole, and enriched in acetylated tubulin. | SIGNOR-260987 |
Q15831 | Q8IWQ3 | 1 | phosphorylation | up-regulates | 0.503 | Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1we recently demonstrated that the lkb1 tumour suppressor kinase, in complex with the pseudokinase strad and the scaffolding protein mo25, phosphorylates and activates amp-activated protein kinase (ampk). A total of 12 human kin... | SIGNOR-122485 |
Q9C0F0 | Q13133 | 2 | binding | down-regulates activity | 0.2 | We determined that ASXL3 depletion augments the ligand-induced transcriptional activities of LXRα and TRβ, which were repressed by ASXL3 overexpression. The ligand-dependent interactions of ASXL3 with LXRα and TRβ were demonstrated by the GST pull-down and immunoprecipitation analyses. We confirmed that ASXL3 suppress... | SIGNOR-266765 |
P12931 | O43597 | 1 | phosphorylation | up-regulates | 0.565 | Activation of signalling by fibroblast growth factor receptor leads to phosphorylation of the signalling attenuator human sprouty 2 (hspry2) on residue y55. we show that hspry2 is a direct substrate for src family kinases, including src itself.Phosphorylation of hspry2 is required for hspry2 to inhibit activation of th... | SIGNOR-131189 |
Q86UP2 | P33176 | 2 | binding | up-regulates | 0.609 | This study demonstrated the effect of kinectin-kinesin interaction on lysosome dynamics and observed that the kinesin-binding domain of kinectin can significantly enhance the mt-stimulated atpase activity of kinesin. | SIGNOR-128092 |
P22607 | Q9UPZ9 | 1 | phosphorylation | down-regulates activity | 0.2 | FGF signaling partially abolished ICK's kinase activity, through FGFR-mediated ICK phosphorylation at conserved residue Tyr15, which interfered with optimal ATP binding. | SIGNOR-277436 |
O43613 | P09471 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257012 |
P25101 | Q14344 | 2 | binding | up-regulates | 0.557 | We studied the ability of et receptors to activate galfa13 using an assay for g protein alfa-chain activation that is based on the fact that an activated (gtp-bound) alfa-chain is resistant to trypsinization compared with an inactive (gdp-bound) alfa-chain. | SIGNOR-66856 |
P23327 | P16615 | 2 | binding | down-regulates activity | 0.374 | Furthermore, a Ser96Asp HRC variant, which mimics constitutive phosphorylation of Ser96, diminished delayed aftercontractions in HRC null cardiac myocytes. This HRC phosphomimetic variant was also able to rescue the aftercontractions elicited by the Ser96Ala variant, demonstrating that phosphorylation of Ser96 is criti... | SIGNOR-273662 |
P06241 | Q01628 | 1 | phosphorylation | up-regulates quantity | 0.452 | We determined that both mouse and human IFITM3 are phosphorylated by the protein-tyrosine kinase FYN on tyrosine 20 (Tyr(20)). Phosphorylation of IFITM3 on Tyr20 Leads to Plasma Membrane Accumulation. | SIGNOR-266304 |
Q9UBE8 | Q12778 | 1 | phosphorylation | down-regulates activity | 0.613 | Here, we report that the transforming growth factor-beta-activated kinase (TAK1)-Nemo-like kinase (NLK) pathway negatively regulates FOXO1. We show that NLK binds and phosphorylates FOXO1 at Pro-directed Ser/Thr residues in the transactivation domain. The phosphorylation by TAK1-NLK pathway inhibits the transcriptional... | SIGNOR-273907 |
P53355 | Q96RR4 | 1 | phosphorylation | down-regulates | 0.283 | Dapk phosphorylates camkk. S511 was identified as the phosphorylation site . a potential mechanism of action was identified on the basis of the location of s511 near the cam recognition domain of camkk and demonstrated by attenuation of cam-stimulated camkk autophosphorylation after dapk phosphorylation. | SIGNOR-126241 |
Q9UQQ2 | O60674 | 2 | binding | down-regulates activity | 0.643 | we identified Lnk as a physiological negative regulator of JAK2 in stem cells and TPO/Mpl/JAK2/Lnk as a major regulatory pathway in controlling stem cell self-renewal and quiescence. we identify a direct interaction between Lnk and the Mpl/JAK2 complex that regulates various HSC functions. | SIGNOR-260075 |
Q15154 | P51955 | 1 | relocalization | up-regulates | 0.425 | Recruitment of nek2 and c-nap1 to the centrosome is dependent on pcm-1 | SIGNOR-133337 |
Q92953 | O95292 | 1 | relocalization | up-regulates quantity | 0.2 | Confirmation that Kv2.1 and -2.2 bind VAPA and VAPB employed colocalization/redistribution, siRNA knockdown, and Förster resonance energy transfer (FRET)-based assays.|As Kv2.1 accumulates on the surface it begins to bind ER VAPs and form the large and stable membrane junctions. | SIGNOR-262123 |
P10721 | O14544 | 0 | ubiquitination | down-regulates | 0.678 | Suppressor of cytokine signaling 6 (socs6) is a member of the socs family of e3 ubiquitin ligases that can interact with c-kit and suppress c-kit-dependent pathways. / we demonstrate that socs6 has ubiquitin ligase activity toward c-kit and regulates c-kit protein turnover in cells | SIGNOR-169145 |
P41240 | Q96J02 | 1 | phosphorylation | down-regulates activity | 0.2 | CISK strongly interacts and colocalizes with the E3 ubiquitin ligase AIP4, which is important for the ubiquitin-dependent lysosomal degradation of CXCR4. Moreover, the observed inhibition is both dependent on the interaction between CISK and AIP4 and on the activation status of CISK. Consistent with this, an activated ... | SIGNOR-245327 |
P28799 | P19438 | 2 | binding | down-regulates | 0.492 | Collectively, these findings demonstrate that pgrn is a ligand of tnfr, an antagonist of tnf signaling, and plays a critical role in the pathogenesis of inflammatory arthritis in mice. | SIGNOR-172684 |
Q00987 | O43463 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.4 | A recent report showed that the p53 inducible E3 ligase MDM2 causes SUV39H1 degradation.|Furthermore, it was reported that MDM2 can ubiquitinate and degrade SUV39H1. | SIGNOR-278631 |
O14746 | P06493 | 0 | phosphorylation | up-regulates activity | 0.324 | Here we report that hTERT is phosphorylated at threonine 249 during mitosis by the serine/threonine kinase CDK1.These observations indicate that phosphorylation at threonine 249 regulates hTERT RdRP and contributes to cancer progression in a telomere independent manner. | SIGNOR-277517 |
Q01196 | Q9UPS8 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | In healthy individual, RUNX1/FLI1 complex negatively regulates ANKRD26 gene expression in MKs. | SIGNOR-266069 |
P12931 | Q16620 | 1 | phosphorylation | up-regulates activity | 0.46 | Indeed, activated Src can directly phosphorylate recombinant TrkB protein in a cell-free system.|We found that both exogenous H 2 O 2 and endogenous ROS activate TrkB signaling by a Src family kinase dependent but brain derived neurotrophic factor independent mechanism in cultured rat cortical neurons. | SIGNOR-280130 |
O60341 | P49841 | 0 | phosphorylation | up-regulates activity | 0.265 | GSK3beta phosphorylates KDM1A serine 683 upon priming phosphorylation of KDM1A serine 687 by CK1alpha.|Together, these results support the notion that GSK3\u03b2 stabilizes KDM1A by decreasing its ubiquitination. | SIGNOR-278225 |
Q92793 | P28069 | 2 | binding | up-regulates activity | 0.381 | We and others have recently shown that CBP can constitutively bind to Pit-1 and synergistically activate transcription of promoters containing Pit-1 DNA-binding sites. | SIGNOR-267204 |
P45974 | P0CG48 | 1 | cleavage | up-regulates quantity | 0.847 | Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, ... | SIGNOR-270822 |
Q13233 | Q13546 | 0 | phosphorylation | up-regulates activity | 0.455 | These findings strongly suggest that rip phosphorylates mekk1 at ser-957 and ser-994. | SIGNOR-108257 |
P54762 | Q03135 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | EphB1-dependent Y-14 phosphorylation of Cav-1 regulates caveolae endocytosis and endothelial permeability. | SIGNOR-280008 |
O43679 | Q9NVW2 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.452 | Here we identify RLIM as a ubiquitin protein ligase that is able to target CLIM cofactors for degradation through the 26S proteasome pathway. | SIGNOR-272616 |
P28482 | P01100 | 1 | phosphorylation | up-regulates activity | 0.792 | We have recently shown that erk phosphorylates multiple residues within the carboxylterminal transactivation domain (tad) of c-fos, thus resulting in its increased transcriptional activity. ERK2 phosphorylated c-Fos TADs that included Thr- 325, Thr-331, or Ser-374 as unique phospho-acceptor sites, thus indicating that ... | SIGNOR-236010 |
Q6W2J9 | P41182 | 2 | binding | up-regulates activity | 0.886 | In this study we have shown that BCoR interacts with BCL-6 and potentiates transcriptional repression by BCL-6 with striking specificity. | SIGNOR-252235 |
Q14789 | O60763 | 2 | binding | up-regulates activity | 0.84 | The “cis-golgin tether” is one of the most well-characterized golgin tether complexes. It is composed of the COPI vesicle-associated golgin giantin linked to Golgi membrane-associated GM130 via p115. GM130 is in turn linked to GRASP65 via a PDZ-like domain. GRASP65 is anchored to the Golgi membrane through N-terminal m... | SIGNOR-261237 |
P01189 | Q01718 | 2 | binding | up-regulates activity | 0.783 | Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3',5'-monophosphate... | SIGNOR-268615 |
Q16665 | P29375 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.273 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271565 |
O75553 | P06241 | 0 | phosphorylation | down-regulates activity | 0.614 | Tyrosine phosphorylation of Dab1 by Fyn inhibits its interaction with APP, while increasing its interaction with Fyn. | SIGNOR-278476 |
O14641 | P34925 | 2 | binding | up-regulates | 0.419 | Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled. | SIGNOR-129571 |
Q9BYP7 | Q9H2X9 | 1 | phosphorylation | down-regulates activity | 0.46 | We have shown that with-no-lysine kinase 3 (WNK3) possesses several properties that suggest it could be the Cl−/volume-sensitive regulatory kinase that, in association with protein phosphatases, reciprocally modifies the phosphorylation/dephosphorylation states of the SLC12 proteins and thus their activities|WNK3 activ... | SIGNOR-264628 |
Q16665 | Q9Y2N7 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.524 | None of the long HIF-3α variants was capable of efficient induction of an HRE reporter in overexpression experiments, but instead inhibited the transcriptional activation of the reporter by HIF-1 and HIF-2. | SIGNOR-261615 |
Q9NWF9 | Q8IUC6 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.355 | Triad3A promotes proteolytic degradation of adapter proteins. A, Triad3A promotes down-regulation of TIRAP, TRIF, and RIP1 proteins. | SIGNOR-271609 |
Q15836 | Q9H6Y7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.328 | Here, we show that Godzilla/RNF167 regulates endosome recycling by the ubiquitylation of VAMP3 on Lys66, Lys68 and Lys77; namely, two adjacent Lys residues on the both sides of the critical interface of SNARE complex are ubiquitylated. In agreement with VAMP3 being a target for Goliath family ubiquitin ligases, we show... | SIGNOR-272093 |
P15172 | P50461 | 2 | binding | up-regulates activity | 0.468 | we found that nuclear MLP functions through a physical interaction with the muscle basic helix-loop-helix (bHLH) transcription factors MyoD, MRF4, and myogenin. we propose that it serves as a cofactor for the myogenic bHLH proteins by increasing their interaction with specific DNA regulatory elements. | SIGNOR-241116 |
P16220-1 | P17676 | 2 | binding | up-regulates activity | 0.56 | We conclude that C/EBP-β can directly bind to the N-terminal Q1 domain of CREB in addition to binding to the leucine zipper domain. The transactivation potential of full-length CREB fused to the DNA-binding domain of Gal4 was increased synergistically by calcium and cGMP, and overexpression of C/EBP-β enhanced the effe... | SIGNOR-263654 |
Q12923 | Q15654 | 1 | dephosphorylation | down-regulates activity | 0.434 | PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration.|Here we further demonstrate that a switch from c-Src-mediated phosphorylation to PTPL1/Fas-associated phosphatase-1-dependent dephosphorylation serves as an inhibitory feedback control mechanism of TRIP6 function in LPA-ind... | SIGNOR-248713 |
P54727 | P07992 | 2 | binding | up-regulates activity | 0.65 | GG-NER is initiated by the GG-NER specific factor XPC-RAD23B, in some cases with the help of UV-DDB (UV-damaged DNA-binding protein). TC-NER is initiated by RNA polymerase stalled at a lesion with the help of TC-NER specific factors CSA, CSB, and XAB2. Both pathways require the core NER factors to complete the excision... | SIGNOR-275703 |
P0DMV8 | Q96M98 | 2 | binding | up-regulates quantity by stabilization | 0.2 | Our in vitro data suggest that CHIP competes with Hsp70 in binding to Parkin, probably via suppression of the ATPase activity of Hsc/Hsp70 (Figure 4E).In fact, it acts as an inhibitory factor that suppresses the ubiquitination of Pael-R mediated by Parkin in vitro, and Hsp70 enhances the efficiency of folding of overex... | SIGNOR-272890 |
Q13315 | Q587J8 | 1 | phosphorylation | up-regulates activity | 0.2 | Notably, we identified two critical residues, Thr145 and Thr156, whose phosphorylation by Ataxia-telangiectasia mutated (ATM) is essential for KHDC3L's functions. | SIGNOR-273505 |
P68400 | Q96PX8 | 1 | phosphorylation | up-regulates activity | 0.2 | In our studies, SICD was phosphorylated by PKA, PKC, and CK2, and association of SLITRK1 with 14-3-3 was regulated by phosphorylation at Ser695. Co-precipitation experiments demonstrated much greater recovery of 14-3-3 in SLITRK1 precipitates when wild-type or S695E was used, as compared with S695A, consistent with the... | SIGNOR-273633 |
Q86UR1 | P28482 | 0 | phosphorylation | down-regulates | 0.326 | These results demonstrated a critical role of noxa1 phosphorylation on ser-282 and ser-172 in preventing nox1 hyperactivation through the decrease of noxa1 interaction to nox1 and rac1. | SIGNOR-163659 |
Q13541 | P06493 | 0 | phosphorylation | down-regulates activity | 0.397 | Phosphorylation of 4e-bp1 is critical in causing its dissociation from eif-4e, leaving 4e available to form translationally active eif-4f complexes, switching on mrna translation. We show that the cyclin-dependent kinase, cdc2, phosphorylates 4e-bp1 at thr-70 and that phosphorylation of this site is permissive for ser-... | SIGNOR-110416 |
P53350 | O00399 | 2 | binding | up-regulates activity | 0.374 | Here, we show that the p27/p25 heterodimer undergoes mitotic phosphorylation by cyclin‐dependent kinase 1 (Cdk1) at a single site, p27 Thr186, to generate an anchoring site for polo‐like kinase 1 (Plk1) at kinetochores. | SIGNOR-264798 |
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