IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
O43318 | Q9BZR9 | 0 | polyubiquitination | up-regulates activity | 0.343 | These results suggest that TRIM8 could mediate K63-linked polyubiquitination of TAK1 at residue K158.These results suggest that TRIM8 is involved in TNFα- and IL-1β–induced NF-κB activation by mediating K63-linked TAK1 polyubiquitination and subsequent activation. | SIGNOR-271890 |
P49841 | Q9Y6H5 | 1 | phosphorylation | down-regulates | 0.487 | Synphilin-1 s556a mutant, which is less phosphorylated by gsk3beta, formed more inclusion bodies than wild type synphilin-1. Mutation analysis showed that ser556 is a major gsk3beta phosphorylation site in synphilin-1 | SIGNOR-140609 |
P08581 | Q96S59 | 2 | binding | up-regulates | 0.557 | Our data suggest that ranbpm, functioning as an adaptor protein for the met tyrosine kinase domain, can augment the hgf-met signaling pathway. | SIGNOR-91028 |
P29350 | P10721 | 2 | binding | down-regulates | 0.576 | Shp-1 binds and negatively modulates the c-kit receptor by interaction with tyrosine 569 in the c-kit juxtamembrane domain. | SIGNOR-56104 |
Q9H093 | Q15831 | 0 | phosphorylation | up-regulates | 0.273 | A total of 12 human kinases (nuak1, nuak2, brsk1, brsk2, qik, qsk, sik, mark1, mark2, mark3, mark4 and melk) are related to ampk. Here we demonstrate that lkb1 can phosphorylate the t-loop of all the members of this subfamily, apart from melk, increasing their activity >50-fold. | SIGNOR-122717 |
P09471 | P21918 | 2 | binding | up-regulates activity | 0.356 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257244 |
Q9Y5X1 | Q05193 | 2 | binding | up-regulates | 0.788 | Snx9 binds directly to bothdynamin-1 anddynamin-2. Moreover by stimulatingdynaminassembly, snx9 stimulatesdynamin's basal gtpase activity and potentiates assembly-stimulated gtpase activity on liposomes. | SIGNOR-133892 |
Q8IXL6 | Q9BRK5 | 1 | phosphorylation | up-regulates activity | 0.2 | Together, these results indicate that Fam20C kinase activity drives the sorting and secretion of the Cab45 dependent client LyzC.|We show that Fam20C phosphorylates Cab45 on distinct residues and thereby decreases Cab45 retention in the TGN. | SIGNOR-279330 |
Q96T68 | Q16695 | 1 | methylation | up-regulates activity | 0.2 | Here, we have characterized a previously undescribed member of the histone H3K9 methyltransferase family named CLLD8 (or SETDB2 or KMT1F). This protein contributes to the trimethylation of both interspersed repetitive elements and centromere-associated repeats and participates in the recruitment of heterochromatin prot... | SIGNOR-263895 |
Q9NYJ7 | P46531 | 2 | binding | up-regulates activity | 0.491 | Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common ... | SIGNOR-209738 |
P19784 | O60936 | 1 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation of ARC at T149 Is Required for Its Antiapoptotic Effect. Here we report that the function of ARC is regulated by protein kinase CK2. ARC at threonine 149 is phosphorylated by CK2. This phosphorylation targets ARC to mitochondria. ARC is able to bind to caspase-8 only when it is localized to mitochondria... | SIGNOR-262836 |
P27361 | Q07866 | 1 | phosphorylation | down-regulates | 0.264 | Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1mutation of klc1ser460 to an alanine residue, to preclude phosphorylation, increased the binding of calsyntenin-1, whereas mutation to an aspartate residueklc1ser460 is a predicted mitogen-activated protein kinase (... | SIGNOR-172642 |
P31431 | Q05655 | 0 | phosphorylation | up-regulates activity | 0.528 | The phosphorylation state of Ser(183) in the cytoplasmic tail of syndecan-4 determines the binding affinity of the cytoplasmic tail to phosphatidylinositol 4,5-bisphosphate (PIP(2)), the capacity of the tail to multimerize, and its ability to activate protein kinase C (PKC) alpha. We sought to identify the kinase respo... | SIGNOR-116265 |
P08581 | P09874 | 1 | phosphorylation | up-regulates activity | 0.388 | Here we show that the receptor tyrosine kinase c-Met associates with and phosphorylates PARP1 at Tyr907 (PARP1 pTyr907 or pY907).|To address whether c-Met activates PARP1, we exposed MDA-MB-231 cells expressing control shRNA or c-Met shRNA to H 2 O 2 and subjected them to a comet assay to evaluate the extent of DNA dam... | SIGNOR-279470 |
P21452 | P63096 | 2 | binding | up-regulates activity | 0.259 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256736 |
Q13085 | Q9NP71 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.435 | The present study provides evidence for a direct and dominant role of ChREBP in the glucose regulation of two key liver lipogenic enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) | SIGNOR-267946 |
O14672 | Q15717 | 0 | post transcriptional regulation | up-regulates quantity | 0.2 | Neuronal ELAV (nELAV) proteins are RNA-binding proteins which play a physiological role in controlling gene expression in memory formation, and their alteration may contribute to cognitive impairment associated with neurodegenerative pathologies such as Alzheimer's disease (AD). The experiments show for the first time ... | SIGNOR-266862 |
Q9UM11 | O14965 | 2 | binding | down-regulates quantity by destabilization | 0.561 | We previously showed that human Aurora-A is turned over through the anaphase promoting complex/cyclosome (APC/C)–ubiquitin–proteasome pathway. The association of two distinct WD40 repeat proteins known as Cdc20 and Cdh1, respectively, sequentially activates the APC/C. The present study shows that Aurora-A degradation i... | SIGNOR-272610 |
P06737 | Q9Y572 | 2 | binding | up-regulates | 0.522 | Rip3 directly interacts with glycogen phosphorylase (pygl), glutamate ammonia ligase (glul), and glutamate dehydrogenase 1 (glud1). Rip kinase activity is required to enhance the activities of all three enzymes both in vivo and in vitro. | SIGNOR-186939 |
P46937 | O43318 | 0 | phosphorylation | down-regulates activity | 0.338 | TAK1 inhibits YAP activity through beta-TRCP.|Thus, our data indicate that TAK1 directly phosphorylates YAP at multiple sites.|These observations prompted us to test whether TAK1 phosphorylates YAP at S127. | SIGNOR-278956 |
O43426 | Q9NQU5 | 0 | phosphorylation | up-regulates activity | 0.2 | We identified two novel Pak5 substrates, Pacsin1 and Synaptojanin1, proteins that directly interact with one another to regulate synaptic vesicle endocytosis and recycling. Pacsin1 and Synaptojanin1 were phosphorylated by Pak5 and the other group II Paks in vitro, and Pak5 phosphorylation promoted Pacsin1-Synaptojanin1... | SIGNOR-263022 |
Q04323 | Q96IV0 | 2 | binding | up-regulates activity | 0.488 | PNGase is directed to polyubiquitinated MGPs via VCP and the adaptor protein SAKS1, allowing PNGase to deglycosylate MGPs, which can then be degraded by the proteasome. PNGase itself is reported to bind to the S4 component of the 19 S proteasome. | SIGNOR-261060 |
P38405 | P08588 | 2 | binding | up-regulates activity | 0.392 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256901 |
P63092 | Q08828 | 2 | binding | up-regulates activity | 0.627 | Because adenylyl cyclases are directly activated by G(s)alpha and the carboxyl termini of the various Galpha proteins determine their receptor coupling specificity, we proposed a set of chimeric G(s)alpha where the COOH-terminal five amino acids are replaced by those of other Galpha proteins and used these to dissect t... | SIGNOR-156958 |
Q9Y243 | Q13043 | 1 | phosphorylation | down-regulates | 0.261 | Full activation of mst1 requires an activation cleavage that is prevented by the phosphorylation of thr-387 by akt. | SIGNOR-201129 |
P55072 | Q96IV0 | 2 | binding | up-regulates activity | 0.695 | PNGase is directed to polyubiquitinated MGPs via VCP and the adaptor protein SAKS1, allowing PNGase to deglycosylate MGPs, which can then be degraded by the proteasome. PNGase itself is reported to bind to the S4 component of the 19 S proteasome. | SIGNOR-261058 |
P56962 | Q9UHD2 | 0 | phosphorylation | up-regulates activity | 0.291 | Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls the formation of the ATG13+FIP200+ mammalian pre-autophagosomal structure (mPAS) in response to induction of autophagy. TBK1 phosphorylates Stx17 at S202. | SIGNOR-273812 |
P10275 | Q15910 | 2 | binding | up-regulates activity | 0.54 | This study demonstrates that phosphorylation of EZH2 at Ser21, mediated directly or indirectly by the PI3K-Akt pathway, can switch its function from a Polycomb repressor to a transcriptional coactivator of AR (and potentially other factors). | SIGNOR-251542 |
Q2TAL8 | P41252 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269406 |
Q9Y6Y1 | P01160 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.429 | CAMTA1 itself stimulates the expression of the anti-proliferative peptide NPPA. | SIGNOR-261570 |
Q9NQU5 | Q9BY11 | 1 | phosphorylation | up-regulates activity | 0.2 | We identified two novel Pak5 substrates, Pacsin1 and Synaptojanin1, proteins that directly interact with one another to regulate synaptic vesicle endocytosis and recycling. Pacsin1 and Synaptojanin1 were phosphorylated by Pak5 and the other group II Paks in vitro, and Pak5 phosphorylation promoted Pacsin1-Synaptojanin1... | SIGNOR-263021 |
P42336 | Q13043 | 0 | phosphorylation | down-regulates activity | 0.2 | MST1/2 and HGK inhibit catalytic activity of p110α through phosphorylation at T1061 | SIGNOR-277920 |
Q15691 | Q7Z460 | 2 | binding | up-regulates activity | 0.61 | CLIP-associating protein (CLASP) 1 and CLASP2 are mammalian microtubule (MT) plus-end binding proteins, which associate with CLIP-170 and CLIP-115.|We demonstrate that the middle part of CLASPs binds directly to EB1 and to MTs. | Both EB1- and cortex-binding domains of CLASP are required to promote MT stability. | SIGNOR-265094 |
P01222 | P28069 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.438 | CBP and Pit-1 acted synergistically in TRH stimulation of the TSH-β promoter. The human TSH-β promoter contains three well defined Pit-1 DNA-binding sites. | SIGNOR-267205 |
P04637 | Q16611 | 2 | binding | up-regulates | 0.691 | P53 interacts with the pro-apoptotic mitochondrial membrane protein bak | SIGNOR-124122 |
Q6SZW1 | Q8IUC6 | 2 | binding | down-regulates | 0.53 | SARM utilizes its TIR domain to negatively regulate TRIF | SIGNOR-252068 |
Q8N5C8 | O15105 | 2 | binding | up-regulates | 0.382 | The formation of smad7-tab2 and smad7-tab3 complexes resulted in the suppression of tnf signaling. | SIGNOR-153920 |
Q12778 | P11802 | 0 | phosphorylation | up-regulates activity | 0.46 | In summary, our study showed that Cdk4 phosphorylates and activates PAX3-FOXO1, thereby promoting its oncogenic function.|These findings suggest that Cdk4 phosphorylates the Ser 430 residue of PAX3-FOXO1 in vitro . | SIGNOR-278377 |
O00311 | Q5FWF5 | 1 | phosphorylation | down-regulates | 0.432 | We show here that eco1 degradation requires the sequential actions of cdk1 and two additional kinases, cdc7-dbf4 and the gsk-3 homolog mck1. | SIGNOR-200397 |
Q96G91 | P09471 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257261 |
P31749 | Q13370 | 1 | phosphorylation | up-regulates | 0.687 | Pde3b is a physiological substrate of akt and that akt-mediated phosphorylation of pde3b on serine-273 is important for insulin-induced activation of pde3b. | SIGNOR-252583 |
P10912 | P18031 | 0 | dephosphorylation | down-regulates activity | 0.501 | PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates | SIGNOR-248420 |
Q8WU20 | P62993 | 2 | binding | up-regulates activity | 0.802 | In this report, we demonstrate that FGF stimulation induces tyrosine phosphorylation of a novel lipid anchored docking protein, termed FRS2, that forms a complex with Grb2/Sos, thus linking FGF-receptor activation to the Ras/MAPK signaling pathway. | SIGNOR-236953 |
P11362 | P51812 | 0 | phosphorylation | down-regulates quantity | 0.357 | Both in vitro and in vivo experiments confirmed the interaction and we show that phosphorylated RSK2 binds to and phosphorylates serine 789 in the C-terminal tail of FGFR1.prevention of FGFR1 phosphorylation by inhibition of RSK2 activity or mutation of serine 789 to alanine reduced FGFR1 endocytosis and ubiquitinatio... | SIGNOR-276599 |
Q969H4 | Q9NS23 | 2 | binding | up-regulates | 0.402 | Cnk1 binds to rassf1a and promotes apoptosis through a pathway that requires rassf1a and mst kinases. | SIGNOR-198432 |
Q92915 | P49841 | 0 | phosphorylation | up-regulates activity | 0.259 | Our laboratory has also demonstrated that FGF14 is a key accessory protein that binds to the intracellular Nav1.6 C-terminal tail, and that GSK3β can phosphorylate FGF14 both in vitro and in vivo at S226 [20] in an experimental model of Alzheimer's disease | SIGNOR-275746 |
Q92633 | P30679 | 2 | binding | up-regulates activity | 0.456 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257282 |
Q49MG5 | O14965 | 0 | phosphorylation | up-regulates | 0.326 | Asap is a novel substrate of the oncogenic mitotic kinase aurora-a: phosphorylation on ser625 is essential to spindle formation and mitosis. | SIGNOR-158210 |
Q15797 | P50750 | 0 | phosphorylation | down-regulates | 0.32 | Phosphorylation of the linker region of smad1, a receptor-activated smad (r-smad), at serine 206 (s206) and s214 induced by bmp and mediated by cdk8/9 is critical for binding of the e3 ubiquitin ligase smurf1. Binding of smurf1 leads to polyubiquitination of smad1 and its degradation by the proteasome;cdk8 and cyclint-... | SIGNOR-161569 |
P52803 | P29322 | 2 | binding | up-regulates | 0.819 | Efna5 are able to activate epha8 | SIGNOR-52479 |
P04629 | P04629 | 2 | phosphorylation | up-regulates | 0.2 | In vitro studies indicate that trka autophosphorylates at tyrosines 490, 670, 674, 675, and 785 | SIGNOR-47171 |
Q01628 | P06241 | 0 | phosphorylation | up-regulates quantity | 0.452 | We determined that both mouse and human IFITM3 are phosphorylated by the protein-tyrosine kinase FYN on tyrosine 20 (Tyr(20)). Phosphorylation of IFITM3 on Tyr20 Leads to Plasma Membrane Accumulation. | SIGNOR-266304 |
Q05513 | P46937 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.277 | Yap and β-catenin are direct substrates of PKCζ.We show here that PKCζ suppresses intestinal stem cell function by promoting the downregulation of β-catenin and Yap through direct phosphorylation.Consistent with MS/MS analysis, mutation to alanine of these two sites completely abolished Yap phosphorylation by PKCζ. In... | SIGNOR-276877 |
P15923 | P28482 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.36 | Notch-induced degradation requires phosphorylation of E47 by p42/p44 MAP kinases. |Wild_type E47 but not the Mm mutant reacted to the antibodies, suggesting that E47 is at least phosphorylated at the M2 site (Figure 3A)|anti_phospho_M2 peptide (SSPSpTPVGSPQG) | SIGNOR-249451 |
P17612 | P41161 | 1 | phosphorylation | up-regulates activity | 0.2 | We further show that the increase in erm transcriptional activity after pka phosphorylation is closely correlated with a drastic reduction in the dna binding of the transcription factor. These results indicate that the phosphorylation of erm by pka is involved in erm-mediated transcription and suggest that the activati... | SIGNOR-111239 |
P22612 | Q6PIY7 | 1 | phosphorylation | down-regulates activity | 0.2 | We found that Gld2 activity is regulated by site-specific phosphorylation in its disordered N-terminal domain. We identified two phosphorylation sites (S62, S110) where phosphomimetic substitutions increased Gld2 activity and one site (S116) that markedly reduced activity. Using mass spectrometry, we confirmed that HEK... | SIGNOR-259404 |
P23443 | P28482 | 0 | phosphorylation | up-regulates | 0.596 | Erk phosphorylates multiple cytoplasmatic and cytoskeletal proteins, including mapk-activated protein kinases and the ribosomal p70-s6 kinase | SIGNOR-28800 |
Q14469 | P53805 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Increased Calcineurin/NFAT activity by Notch signaling involves downregulation of Calcipressin, an endogenous Calcineurin inhibitor, through a HES-1-dependent mechanism .... Chromatin immunoprecipitation (ChIP) analysis of keratinocytes overexpressing HES-1 showed that this protein can bind to the HES binding sites pre... | SIGNOR-252026 |
P17612 | Q9HC16 | 1 | phosphorylation | up-regulates | 0.324 | Here we show that pka binds and specifically phosphorylates a3g at thr32 in vitro and in vivo. This phosphorylation event reduces the binding of a3g to vif and its subsequent ubiquitination and degradation, and thus promotes a3g antiviral activity. | SIGNOR-181526 |
P68431 | Q8TF76 | 0 | phosphorylation | up-regulates activity | 0.2 | Here we show that phosphorylation of histone H3 threonine 3 (H3T3ph) by Haspin is necessary for CPC accumulation at centromeres and that the CPC subunit Survivin binds directly to H3T3ph. | SIGNOR-275428 |
P53350 | O75122 | 1 | phosphorylation | up-regulates activity | 0.622 | Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments.|Finally, we demonstrate that CLASP2 phosphorylation on S1234 and S1255 by Cdk1 and Plk1, respectively, increases with conditions that allow the establishment and stabilization of KT\u2013MT attachments ( xref ). | SIGNOR-278321 |
Q6ZNA4 | O15169 | 2 | binding | up-regulates | 0.642 | Here, we show that axin activates tgf-beta signaling by forming a multimeric complex consisting of smad7 and ubiquitin e3 ligase arkadia. Axin is a scaffold protein in tgf-beta signaling that promotes degradation of smad7 by arkadia. | SIGNOR-119660 |
P21860 | O14511 | 2 | binding | up-regulates | 0.82 | Direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3.The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-... | SIGNOR-26881 |
P16157 | O14983 | 2 | binding | down-regulates activity | 0.293 | We recently reported that small ankyrin 1 (sAnk1) interacts with the sarco(endo)plasmic reticulum Ca2+-ATPase in skeletal muscle (SERCA1) to inhibit its activity. | SIGNOR-265927 |
Q13191 | P27986 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.517 | Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.Here it is shown that Cbl-b interacts with and induces ubiquitin conjugation to the p85 regulatory subunit of phosphatidylinositol 3-kinase, an upstream regulator of Vav. | SIGNOR-272583 |
P28482 | P49795 | 1 | phosphorylation | up-regulates | 0.474 | Phosphorylation of gaip by erk2 were abrogated when serine at position 151 in the rgs domain was substituted by an alanine residue using site-directed mutagenesis. Furthermore, the lysosomal-autophagic pathway was not stimulated in s151a-gaip mutant-expressing cells when compared with wild-type gaip-expressing cells. T... | SIGNOR-129883 |
O15524 | P07948 | 0 | phosphorylation | down-regulates activity | 0.301 | These findings show that SOCS1 phosphorylation by the SRC family inhibits its tumor-suppressive activity, indicating that patients with increased SOCS1 phosphorylation may benefit from SRC family kinase inhibitors. | SIGNOR-277888 |
P62136 | O95786 | 1 | dephosphorylation | up-regulates activity | 0.2 | We identified PP1alpha and PP1gamma as primary phosphatases responsible for MDA5 and RIG-I dephosphorylation, leading to their activation.|endogenous RIG-I and MDA5 that interacted with PP1 exhibited markedly decreased phosphorylation levels at S8 and S88, respectively | SIGNOR-264581 |
Q9NPG1 | P63211 | 2 | binding | up-regulates | 0.398 | In the non-canonical wnt signalling pathway, frizzled uses galphaq or galphai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat. | SIGNOR-152606 |
Q03113 | P53041 | 2 | binding | up-regulates activity | 0.326 | In this study, we show that active forms of Gna12 and Gna13 specifically interact with PP5 through its TPR domain and activate its phosphatase activity about 2.5-fold. | SIGNOR-278080 |
Q13546 | Q8TE49 | 0 | deubiquitination | down-regulates activity | 0.2 | NF-kappaB Suppression by the Deubiquitinating Enzyme Cezanne|Our study provides several lines of evidence to suggest that Cezanne suppresses TNFR signaling to NF-κB by targeting RIP1 for deubiquitination. | SIGNOR-268410 |
P05129 | P28329 | 1 | phosphorylation | up-regulates | 0.321 | We show that chat is differentially phosphorylated by protein kinase c (pkc) isoforms on four serines (ser-440, ser-346, ser-347, and ser-476) and one threonine (thr-255). This phosphorylation is hierarchical, with phosphorylation at ser-476 required for phosphorylation at other serines. Phosphorylation at some, but no... | SIGNOR-129320 |
Q9UHD2 | Q13114 | 2 | binding | up-regulates activity | 0.903 | MAVS also interacts with STING that locates at the ER (endoplasmic reticulum), and induces the ubiquitination and dimerization of STING. The activated STING recruits TBK1 and IRF3 and contributes to the phosphorylation of IRF3 mediated by TBK1. | SIGNOR-260156 |
P04083 | P24723 | 0 | phosphorylation | up-regulates | 0.2 | The authors identified several phosphorylated residues by a combination of peptide mapping and sequence analysis and showed that recombinant pp60c-src phosphorylates annexin a1 near its amino terminus, at tyrosine 21 (tyr21). Also polyoma virus middle t/pp60c-src complex, recombinant pp50v-abl, and the egf receptor/kin... | SIGNOR-202792 |
P25054 | P49674 | 0 | phosphorylation | up-regulates activity | 0.614 | Apc can be phosphorylated by ck1epsilon at ser1279 and ser1392. Mutation of conserved serine residues in the beta-catenin regulatory motifs of APC interfered with both axin-dependent phosphorylation and phosphorylation by CKIepsilon and impaired the ability of APC to regulate beta-catenin. | SIGNOR-109664 |
Q9UL62 | P17612 | 0 | phosphorylation | down-regulates quantity | 0.2 | Together, these results suggest that TRPC5 is directly phosphorylated by G(s)/cAMP/PKA at positions S794 and S796. These inhibitory effects were blocked by the protein kinase A (PKA) inhibitors, KT-5720 and H-89, as well as by two point mutations at consensus PKA phosphorylation sites on TRPC5 (S794A and S796A). | SIGNOR-277823 |
Q15796 | P27037 | 0 | phosphorylation | up-regulates activity | 0.71 | In ACVR2A/B dKO parental cells, only ACVR2A , but not ACVR2A , could rescue both pSMAD2 and pSMAD1/5 (Fig\u00a04B).|In marked contrast, in ACVR2A/B dKO HOM1 cells, ACVR2A restored SMAD1/5 phosphorylation, but not SMAD2 phosphorylation (Fig\u00a04C). | SIGNOR-279786 |
Q12778 | P15884 | 2 | binding | down-regulates activity | 0.267 | Here we show that the beta-catenin binding to FOXO serves a dual effect. beta-catenin, through binding, enhances FOXO transcriptional activity. In addition, FOXO competes with TCF for interaction with beta-catenin, thereby inhibiting TCF transcriptional activity. | SIGNOR-262529 |
O95644 | P52333 | 0 | phosphorylation | up-regulates activity | 0.383 | Here we found that IL-7-Jak3 signals activated the transcription factor NFATc1 in DN thymocytes by phosphorylating Tyr371 in the regulatory region of NFATc1. | SIGNOR-276435 |
P84022 | Q8NG27 | 0 | ubiquitination | down-regulates activity | 0.391 | In summary, these results indicated that PJA1 promotes the ubiquitination of phosphorylated SMAD3, resulting in reduced activity of a TGF-\u03b2/SMAD3/\u03b22SP-dependent tumor-suppressing pathway in HCC cells ( xref ). | SIGNOR-278832 |
O15055 | P14859 | 2 | binding | down-regulates activity | 0.2 | This PER2-OCT1 interaction effectively converted OCT1 sites, which normally activate expression, into repressor sites by recruitment of a polycomb repressor complex including EZH2 and SUZ12, as well as HDAC2. | SIGNOR-254148 |
Q13639 | P50148 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257367 |
P53350 | P30307 | 1 | phosphorylation | up-regulates | 0.804 | The nuclear accumulation of active m-phase promoting factor (mpf) during prophase is thought to be essential for coordinating m-phase events in vertebrate cells. The protein phosphatase cdc25c, an activator of mpf, enters the nucleus to keep mpf active in the nucleus during prophase. these results suggest that plk1 pho... | SIGNOR-115993 |
Q01543 | P15976 | 2 | binding | up-regulates activity | 0.518 | On the other hand, our data demonstrate that FLI-1 also interacts with GATA-1. However, FLI-1 does not repress but enhances GATA-1 activity. | SIGNOR-256045 |
Q05397 | P31749 | 0 | phosphorylation | up-regulates activity | 0.43 | In mouse embryonic fibroblasts, AKT1 phosphorylates S695 and T700 on FAK ( xref ) and in human colon cancer cells AKT1 phosphorylates S517, S601, and S695 on FAK ( xref , xref ).|This suggests that further activation of FAK by AKT1 ( beyond that of Pten loss alone ) is required to promote FA turnover , increase tumor i... | SIGNOR-279777 |
P24941 | P18858 | 1 | phosphorylation | up-regulates activity | 0.457 | We show that three residues (ser51, ser76, and ser91), which are part of cyclin-dependent kinase sites, are phosphorylated in a cell cycle-dependent manner. | SIGNOR-103254 |
P29371 | P63096 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257066 |
P06744 | Q14258 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.25 | Gp78 is a ubiquitin ligase that plays a vital role in endoplasmic reticulum (ER)-associated degradation (ERAD). Here we report that autocrine motility factor (AMF), also known as phosphoglucose isomerase (PGI), is a novel substrate of gp78. We show that polyubiquitylation of AMF requires cooperative interaction between... | SIGNOR-272178 |
Q68DK7 | Q16778 | 1 | monoubiquitination | down-regulates activity | 0.2 | MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34u... | SIGNOR-271977 |
Q9NPG1 | O96014 | 2 | binding | up-regulates activity | 0.656 | Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. | SIGNOR-141428 |
O43614 | P50148 | 2 | binding | up-regulates activity | 0.45 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257216 |
O95613 | Q96SN8 | 2 | binding | up-regulates activity | 0.819 | Our observation that Cep215 may function downstream of pericentrin suggests that the two proteins affect centrosome cohesion through a common mechanism. |Finally, depletion of pericentrin caused an almost complete loss of Cep215 from centrosomes, a detectable reduction in centrosomal levels of Cep68 and rootletin, but ... | SIGNOR-260309 |
Q13507 | Q13976 | 0 | phosphorylation | down-regulates | 0.408 | The present study demonstrates that human trpc3 expressed in hek293 cells forms store-operated ca2+ influx channels, the activity of which is inhibited by pkg. The inhibition is due to a direct phosphorylation of pkg on trpc3 channels at position t11 and s263. | SIGNOR-142961 |
Q9UPX8 | Q9Y2H0 | 0 | relocalization | up-regulates activity | 0.744 | SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK prot... | SIGNOR-264596 |
Q9UKE5 | P06396 | 1 | phosphorylation | up-regulates activity | 0.499 | In vitro , TNIK can phosphorylate and activate the F-actin-fragmenting enzyme gelsolin, and in cultured cells, TNIK induces actin fiber disassembly ( xref ).|In vitro, TNIK can phosphorylate and activate the F-actin-fragmenting enzyme gelsolin, and in cultured cells, TNIK induces actin fiber disassembly. | SIGNOR-280154 |
O94855 | Q9NR31 | 2 | binding | up-regulates quantity | 0.714 | Biogenesis of COPII vesicles is initiated by the activation of the small guanosine triphosphate (GTP)-binding protein secretion-associated Ras-related protein 1 (Sar1) at specialized subdomains of the ER, called ER exit sites (ERES) or transitional ER (tER). Membrane-bound Sar1 then recruits the inner COPII coat subcom... | SIGNOR-265301 |
Q15025 | Q86VP1 | 1 | relocalization | up-regulates activity | 0.45 | ABIN1 interacted with the A20 regulatory molecule TAX1BP1 and was essential for the recruitment of TAX1BP1 and A20 to the noncanonical IkappaB kinases TBK1 and IKKi in response to poly(I:C) transfection. ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenua... | SIGNOR-275735 |
P41595 | P19086 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257022 |
P11229 | P08754 | 2 | binding | up-regulates activity | 0.343 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256878 |
Q96BN8 | P0CG47 | 1 | cleavage | up-regulates quantity | 0.671 | Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, ... | SIGNOR-270819 |
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