IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40 values | effect stringclasses 10 values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P54764 | P52803 | 0 | binding | up-regulates | 0.945 | Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). In either case, binding of a ligand results in eph receptor autophosphorylation on tyrosine residues and activation of the kinase activity of the eph receptor | SIGNOR-52473 |
P25054 | O15169 | 0 | binding | up-regulates activity | 0.944 | Axin, an inhibitor of the wnt pathway, interacts with beta-catenin, gsk-3beta and apc and reduces the beta-catenin level. | SIGNOR-60043 |
O43684 | O43683 | 0 | relocalization | up-regulates activity | 0.943 | Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity | SIGNOR-252019 |
P29320 | P52803 | 0 | binding | up-regulates | 0.943 | Highly promiscuous for ephrin-a ligands it binds preferentially efna5 and became active. | SIGNOR-52470 |
P51532 | Q12824 | 0 | binding | up-regulates activity | 0.943 | The remodeling activity of brg1 and hbrm is stimulated by baf170/baf155 and is further stimulated when ini1 is added. | SIGNOR-65438 |
P67775 | P30154 | 0 | binding | up-regulates activity | 0.943 | Since B_ suppresses the association of the catalytic C and regulatory A subunits of protein phosphatase 2A [94], the B_ interaction with the receptor is expected to result in enhanced protein phosphatase 2A activity | SIGNOR-217872 |
Q92643 | Q96S52 | 0 | binding | up-regulates activity | 0.943 | To determine roles for PIG-S and PIG-T, we disrupted these genes in mouse F9 cells by homologous recombination. PIG-S and PIG-T knockout cells were defective in transfer of GPI to proteins, particularly in formation of the carbonyl intermediates. We also demonstrate that PIG-S and PIG-T form a protein complex with GAA1 and GPI8, and that PIG-T maintains the complex by stabilizing the expression of GAA1 and GPI8. | SIGNOR-261362 |
P24394 | P05112 | 0 | binding | up-regulates | 0.942 | IL-4R Is a 140-kd protein that binds il-4 with high affinity | SIGNOR-100762 |
Q13635 | Q15465 | 0 | binding | down-regulates activity | 0.942 | In the responding cell, active Hedgehog binds to its receptor Patched, a 12-pass transmembrane protein, which frees Smoothened, an adjacent 7-pass transmembrane protein, for downstream signaling.Thus, a balance is created by the antagonism of Hedgehog and Patched, whose relative concentrations alternate with respect to each other. | SIGNOR-118615 |
P51587 | Q86YC2 | 0 | binding | up-regulates | 0.942 | Palb2 colocalizes with brca2 in nuclear foci, promotes its localization and stability in key nuclear structures (e.g., chromatin and nuclear matrix), and enables its recombinational repair and checkpoint functions. | SIGNOR-147217 |
Q9NZ42 | Q8WW43 | 0 | binding | up-regulates | 0.942 | Furthermore, overexpression of aph-1 facilitates pen-2-mediated ps1 proteolysis, resulting in a significant increase in ps1 fragments. Our data reveal a direct role of pen-2 in proteolytic cleavage of ps1 and a regulatory function of aph-1, in coordination with pen-2, in the biogenesis of the ps1 complex. | SIGNOR-97110 |
Q99741 | P24941 | 0 | phosphorylation | down-regulates activity | 0.942 | Hscdc6 is an excellent substrate for cdk2 in vitro and is phosphorylated in vivo at three sites (ser-54, ser-74, and ser-106)|An HsCdc6A1A2A3 mutant, which mimics unphosphorylated HsCdc6, is exclusively nuclear, and its expression inhibits initiation of DNA replication. An HsCdc6E1E2E3 mutant, which mimics phosphorylated HsCdc6, is exclusively cytoplasmic and is not associated with the chromatin/nuclear matrix fraction. | SIGNOR-67544 |
O76094 | P09132 | 0 | binding | up-regulates activity | 0.942 | Mammalian SRP comprises the highly base-paired SRP RNA (also referred to as 7SL RNA) of ∼300 nt and six proteins (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) (Figure (Figure1A).1A). The hierarchy of protein addition always starts with the scaffolding protein SRP19 (together with SRP9/14 for the entire SRP) followed by SRP68/72 and finally by SRP54. | SIGNOR-261166 |
Q13153 | P60953 | 0 | binding | up-regulates activity | 0.942 | A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. | SIGNOR-248243 |
P33993 | O00311 | 0 | phosphorylation | up-regulates | 0.942 | We propose that phosphorylation of mcm4/6 s/tp sites, which are already phosphorylated in g1, allows initial mcm2-7 phosphorylation by ddk and initiation from the first origins of replication ( fig. 7ai ). | SIGNOR-169506 |
O00300 | O14788 | 0 | binding | up-regulates | 0.942 | Receptor activator of nf-kappa b ligand (rankl, also known as odf and opgl), a member of the tumor necrosis factor (tnf) family, triggers osteoclastogenesis by forming a complex with its receptor, rank. | SIGNOR-112539 |
Q9UJ41 | Q15276 | 0 | binding | up-regulates | 0.942 | We show that rabaptin-5 increases the exchange activity of rabex-5 on rab5. | SIGNOR-109395 |
Q8N122 | Q9HB90 | 0 | binding | up-regulates | 0.941 | Active rag and gtr heterodimers are able to bind and activate torc1, through direct interactions with raptor. | SIGNOR-162054 |
P11802 | P38936 | 0 | binding | down-regulates | 0.941 | P21cip1 is a cyclin-dependent kinase (cdk) inhibitor that is transcriptionally activated by p53 in response to dna damage.We Have explored the interaction of p21 with the currently known cdks. p21 effectively inhibits cdk2, cdk3, cdk4, and cdk6 kinases. | SIGNOR-29957 |
P16220 | Q92793 | 0 | binding | up-regulates | 0.941 | When overexpressed in serum-stimulated cells, akt/pkb potently induced ser-133 phosphorylation of creb and promoted recruitment of cbp. | SIGNOR-62260 |
O95835 | Q9H8S9 | 0 | binding | up-regulates | 0.941 | Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1 | SIGNOR-169752 |
P49810 | Q92542 | 0 | binding | up-regulates | 0.941 | Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and presenilin 2. | SIGNOR-81936 |
P49023 | Q14289 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.94 | P130Cas and paxillin can be phosphorylated by Fak or Pyk2, and bind directly to these kinases. | SIGNOR-279272 |
Q16620 | P34130 | 0 | binding | up-regulates | 0.94 | Its interactions with trkb can be distinguished from those of brain-derived neurotrophic factor (bdnf) with trkb. | SIGNOR-31644 |
Q9UPY3 | Q15633 | 0 | binding | up-regulates | 0.94 | Dicer and trbp interact in vivo and in vitro /our data indicate that trbp is primarily required for the assembly and/or functioning of si? Or mi?RISCs In mammalian cells, but it may also facilitate the cleavage of pre?miRNAs By dicer. | SIGNOR-140226 |
Q92542 | Q8WW43 | 0 | binding | up-regulates | 0.94 | By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain.These data indicate that maph-1 is probably a functional component of the gamma-secretase complex | SIGNOR-93307 |
P42574 | P98170 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.939 | Xiap promotes the degradation of active-form caspase-3, but not procaspase-3, in living cells. Both the association of XIAP with caspase-3 and the RING finger domain of XIAP were essential for ubiquitination. XIAP promotes the degradation of caspase-3, which enhances its anti-apoptotic effect. | SIGNOR-109243 |
P06730 | Q13541 | 0 | binding | down-regulates activity | 0.939 | The rate-limiting factor for translation is eukaryotic translation initiation factor 4E (eIF4E), which is negatively regulated by eIF4E-binding protein 1 (4E-BP1). | SIGNOR-167176 |
Q8NEB9 | Q99570 | 0 | binding | up-regulates | 0.939 | Recombinant p150 associated with ptdins 3-kinase in vitro in a stable manner, resulting in a 2-fold increase in lipid kinase activity. | SIGNOR-45664 |
Q8TAQ2 | P51532 | 0 | binding | up-regulates | 0.939 | The remodeling activity of brg1 and hbrm is stimulated by baf170/baf155 and is further stimulated when ini1 is added. | SIGNOR-65444 |
P07333 | P09603 | 0 | binding | up-regulates activity | 0.938 | The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34) | SIGNOR-255568 |
P35222 | O00512 | 0 | binding | up-regulates | 0.938 | The transcriptional activity of beta-catenin depends on bcl-9. Bcl-9 functions in targeting beta-catenin to the nucleus and thus increases the transcriptional activity of beta-catenin | SIGNOR-126059 |
Q9Y6A5 | O14965 | 0 | phosphorylation | up-regulates activity | 0.937 | We show that this conserved serine on human TACC3 (Ser(558)) is also phosphorylated by Aurora A. Moreover, phosphorylation of TACC3 by Aurora A in human cells is essential for its proper localization to centrosomes and proximal mitotic spindles. Inhibition of Aurora A with the selective small molecule inhibitor MLN8054 in cultured human tumor cells resulted in mislocalization of TACC3 away from mitotic spindles in a concentration-dependent manner. | SIGNOR-262655 |
P51681 | P13501 | 0 | binding | up-regulates activity | 0.937 | CCL5, also known RANTES (regulated on activation, normal T cell expressed and secreted), is a potent chemoattractant for a variety of leukocytes, including T cells, mono- cytes, NK cells, and basophils, signaling via the CCR1, CCR3, and CCR5 cell surface receptors [59]. Among these receptors, CCL5 has the highest affinity for CCR5. | SIGNOR-277726 |
P62753 | P23443 | 0 | phosphorylation | up-regulates activity | 0.937 | A knockin mouse carrying mutations at all phosphorylation sites in the primary s6k substrate, ribosomal protein s6 (rps6), has provided insight into the physiological role of this protein phosphorylation event. Of the many known substrates of s6k1, it is rps6 that has been shown to be directly involved, via its phosphorylation, in controlling cell size. | SIGNOR-135176 |
O94817 | O95352 | 0 | binding | up-regulates | 0.937 | Analogous to ubiquitination, atg12 is conjugated to atg5 by atg7--an e1-like protein--and atg10--an e2-like protein. | SIGNOR-180132 |
Q7Z434 | O95786 | 0 | binding | up-regulates activity | 0.937 | Initially, RIG-I and MDA5 sense dsRNA in the cytoplasm, produced as a by-product of RNA virus replication.Once one or both of these sensors are activated, they interact with a mitochondrial membrane protein called MAVS (mitochondrial antiviral) (also called IPS1, Cardif, and VISA). They signal to the mitochondrial membrane protein MAVS, which in turn activates the kinases TBK1 and IKKɛ. | SIGNOR-260139 |
P29317 | P20827 | 0 | binding | up-regulates | 0.937 | Ephrin-a1 binds and activates the tyrosine kinase activity of eph-a2, and has a dissociation constant of 20_30 nm | SIGNOR-56901 |
Q13546 | Q15628 | 0 | binding | up-regulates activity | 0.937 | We show that tradd interacts strongly with rip;rip is a serinethreonine kinase that is recruited by tradd to tnfr1 in a tnf-dependent process. | SIGNOR-40043 |
O43318 | Q9NYJ8 | 0 | binding | up-regulates activity | 0.936 | Our results indicate that two distinct TAK1 complexes are present in cells. One comprises TAK1 complexed with TAB1 and TAB2, and the other TAK1 complexed with TAB1 and TAB3. Both complexes are activated in response to tumour necrosis factor-alpha or interleukin-1 in human epithelial KB cells or bacterial lipopolysaccharide in RAW264.7 macrophages | SIGNOR-120268 |
Q14457 | Q8NEB9 | 0 | binding | up-regulates activity | 0.936 | The beclin 1-vps34 interaction regulates autophagy. | SIGNOR-184521 |
Q15116 | Q9NZQ7 | 0 | binding | up-regulates | 0.936 | Pd-l1, was found to bind pd-1 specifically. The functional significance of this interaction has been demonstrated in t cell assays, in which engagement of pd-1 by pd-l1 leads to the inhibition of tcr-mediated lymphocyte proliferation and cytokine secretion. | SIGNOR-82604 |
P51677 | P51671 | 0 | binding | up-regulates | 0.936 | Eotaxin (CCL11) is a specific ligand for CCR3 and serves as a potent chemoattractant for eosinophils | SIGNOR-254356 |
P23921 | Q7LG56 | 0 | binding | up-regulates activity | 0.935 | Taken together, we conclude that UV-induced activation of p53R2 transcription and binding of p53R2 to hRRM1 to form RR holoenzyme are impaired in the p53-mutant cell line PC3. | SIGNOR-259366 |
P04049 | P01112 | 0 | binding | up-regulates | 0.935 | We have examined whether the other two members of the Raf family, A-Raf and B-Raf, are regulated in a similar way to Raf-1. A-Raf behaves like Raf-1, being weakly activated by oncogenic Ras more strongly activated by oncogenic Src, and these signals synergize to give maximal activation. B-Raf by contrast is strongly activated by oncogenic Ras alone and is not activated by oncogenic Src. | SIGNOR-235786 |
Q12834 | P06493 | 0 | phosphorylation | down-regulates activity | 0.935 | Cdk1 phosphorylates Cdc20 to negatively regulate its ability to bind and activate the APC/C. | SIGNOR-279321 |
P35916 | P49767 | 0 | binding | up-regulates | 0.935 | Vegf-c, was isolated as a ligand for the tyrosine kinase vegfr-3 (flt4) | SIGNOR-55205 |
P10721 | P21583 | 0 | binding | up-regulates activity | 0.934 | The most relevant and still unique mast-cell growth factor is SCF, which is the ligand of KIT, a receptor with tyrosine-kinase activity that is expressed on the surface of all human and murine mast cells | SIGNOR-254946 |
P06213 | P01308 | 0 | binding | up-regulates activity | 0.934 | Our previous studies indicated that amino acid residues 240-250 in the cysteine-rich region of the human insulin receptor alpha-subunit constitute a site in which insulin binds. | SIGNOR-23001 |
P07900 | P31948 | 0 | binding | down-regulates activity | 0.934 | Hsp90 chaperone cycle is tightly regulated by another group of proteins referred to as ‘co-chaperones'. Their stability does not depend on Hsp90 function but they interact with distinct Hsp90 conformational states, providing directionality to the Hsp90 cycle. Furthermore, certain co-chaperones, such as HOP and Cdc37p50 inhibit the Hsp90 chaperone cycle, assisting in delivery of distinct sets of client proteins (steroid hormone receptors and kinases, respectively) to the Hsp90 chaperone machine. | SIGNOR-261411 |
O14763 | P50591 | 0 | binding | up-regulates | 0.934 | Tumour necrosis factor-related apoptosis inducing ligand (trail) receptor 2 (trail-r2) also known as tnfrsf10b (tumour necrosis factor receptor (tnfr) super family 10b) or killer/dr5, a member of the tnfr family, is a promising candidate tumour suppressor gene at 8p21-22. | SIGNOR-134524 |
O00220 | P50591 | 0 | binding | up-regulates | 0.934 | Trail interacts with tril-r1 and trail-r2 and activetes them | SIGNOR-101082 |
Q9NQZ2 | O00566 | 0 | binding | up-regulates activity | 0.934 | Mpp10 is able to bind the ribosome biogenesis factor Utp3/Sas10 through two conserved motifs in its N-terminal region. In addition, Mpp10 interacts with the ribosomal protein S5/uS7 using a short stretch within an acidic loop region. Thus, our findings reveal that Mpp10 provides a platform for the simultaneous interaction with multiple proteins in the 90S pre-ribosome. | SIGNOR-261176 |
Q92574 | P49815 | 0 | binding | up-regulates activity | 0.934 | Furthermore, tsc2 is directly phosphorylated by akt, which is involved in stimulating cell growth and is activated by growth stimulating signals, such as insulin. Tsc2 is inactivated by akt-dependent phosphorylation, which destabilizes tsc2 and disrupts its interaction with tsc1. | SIGNOR-77400 |
Q9NYJ8 | Q9Y4K3 | 0 | binding | up-regulates activity | 0.933 | The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. | SIGNOR-205458 |
P63241 | P49366 | 0 | post translational modification | up-regulates activity | 0.933 | Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic translation initiation factor 5A (eIF5A). Hypusine is essential for eIF5A activation, which, in turn, plays a key role in regulating protein translation of selected mRNA that are associated with the synthesis of oncoproteins, thereby enhancing tumor cell proliferation. | SIGNOR-266374 |
O00401 | O43516 | 0 | binding | up-regulates activity | 0.933 | Recruitment of N-WASP to vaccinia is mediated by WASP-interacting protein (WIP), whereas in Shigella WIP is recruited by N-WASP. Our observations show that vaccinia and Shigella activate the Arp2/3 complex to achieve actin-based motility, by mimicking either the SH2/SH3-containing adaptor or Cdc42 signalling pathways to recruit the N-WASP-WIP complex. | SIGNOR-261880 |
Q9NPI8 | Q8IYD8 | 0 | binding | up-regulates | 0.932 | Protein interaction motifs in fancm, designated mm1 and mm2, were identified. Mm1 interacts with the fa core complex by binding to fancf, whereas mm2 interacts with rm1 and topoisomerase iiialpha, components of the bs complex. | SIGNOR-163101 |
Q14790 | Q13158 | 0 | binding | up-regulates activity | 0.931 | Fadd recruits caspase-8 through homotypic interactions of death-effector domains (deds), leading to caspase-8 activation and apoptosis. In turn, fadd recruits the zymogen form of the apoptosis-initiating protease caspase-8, through homophilic interaction of death effector domains. | SIGNOR-112061 |
P20333 | P01375 | 0 | binding | up-regulates activity | 0.93 | The binding of tnf to tnf-r1 triggers a series of intracellular events that ultimately result in the activation of two major transcription factors, nuclear factor kb (nf-kb) and c-jun. | SIGNOR-88216 |
P30989 | P30990 | 0 | binding | up-regulates | 0.93 | The rat neurotensin receptor cdna sequence was transfected in chinese hamster ovary cells and cellular clones which stably express the corresponding protein were isolated and characterized. The scatchard analysis of the specific binding of [3h]neurotensin indicated a kd value of 0.45 +/- 0.08 nm and a bmax value of 3.27 +/- 0.29 pmol/mg of protein. ...Neurotensin Stimulated the phosphoinositides hydrolysis | SIGNOR-17369 |
P25942 | P29965 | 0 | binding | up-regulates activity | 0.929 | Ramos cells were mixed with increasing numbers of transfected cells that expressed cd70 (cd27l) or cd154 (cd40l), both of which are expressed by activated T cells, in the presence of anti-igm ab. Cd27 ligation as well as cd40 ligation inhibited bcr-mediated apoptosis in a dose-dependent manner. cd40 binds its ligand cd40l. | SIGNOR-93432 |
P06400 | P11802 | 0 | phosphorylation | down-regulates | 0.929 | Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression. | SIGNOR-200487 |
O76075 | O00273 | 0 | binding | down-regulates | 0.929 | Dff is a heterodimer of 40 kda and 45 kda subunits. | SIGNOR-29729 |
P36894 | P12643 | 0 | binding | up-regulates | 0.929 | BMP interacts with specific receptors on the cell surface, BMP receptor types 1 and 2 (BMPr1 and BMPr2). | SIGNOR-253547 |
P50542 | O75381 | 0 | binding | up-regulates activity | 0.929 | The peroxisomal docking complex is a key component of the import machinery for matrix proteins. The core protein of this complex, Pex14, is thought to represent the initial docking site for the import receptors Pex5 and Pex7. | SIGNOR-253027 |
P08581 | P14210 | 0 | binding | up-regulates | 0.928 | Hgf is the ligand for p190met, the receptor tyrosine kinase encoded by the met proto-oncogene. | SIGNOR-38429 |
P20339 | Q15276 | 0 | binding | up-regulates | 0.928 | We have previously shown that rab5, which regulates various steps of transport along the early endocytic pathway, is activated by a complex consisting of rabex-5, a rab5 nucleotide exchange factor, and the effector rabaptin-5. | SIGNOR-109352 |
O14980 | P62826 | 0 | binding | up-regulates activity | 0.928 | The nuclear export by CRM1 requires an interaction with the small GTPase Ras-related nuclear antigen (Ran), which cycles between GTP- and GDP-bound states. The binding of Ran GTP to CRM1 in the nucleus increases the affinity of CRM1 for cargo proteins | SIGNOR-275848 |
Q15561 | P46937 | 0 | binding | up-regulates activity | 0.927 | The multifunctional cytokine TGF-β has been identified as a potent inducer of CTGF expression, activating CTGF transcription through the canonical Smad signaling pathway. It is worth noting that TGF-β synergizes with Hippo–Yes-associated protein (YAP) signaling, a key regulator of tumorigenesis, to induce the expression of CTGF by the formation of a YAP-TEAD4-Smad3-p300 complex on the CTGF promoter | SIGNOR-277685 |
P01589 | P60568 | 0 | binding | up-regulates | 0.927 | Il-2 is a cytokine that functions as a growth factor and central regulator in the immune system and mediates its effects through ligand-induced hetero-trimerization of the receptor subunits il-2r alpha, il-2r beta, and gamma(c). | SIGNOR-144537 |
P16109 | Q14242 | 0 | binding | up-regulates | 0.927 | The major ligand for p-selectin on leukocytes is p-selectin glycoprotein ligand-1 (PSGL-1) | SIGNOR-47625 |
Q13541 | P42345 | 0 | phosphorylation | down-regulates activity | 0.926 | Specifically as part of mTORC1, mTOR directly phosphorylates the ribo- somal protein S6 kinases (S6K1 and S6K2) and the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BP1 and 4E-BP2), both of which control specific steps in the initiation of cap-dependent translation | SIGNOR-167184 |
P17542 | P25791 | 0 | binding | up-regulates | 0.926 | Transcriptional activity of tal1 in t cell acute lymphoblastic leukemia (t-all) requires rbtn1 or -2 | SIGNOR-46161 |
P19438 | P01375 | 0 | binding | up-regulates activity | 0.925 | For TNFR1, the cytokine TNFα binds to the receptor and triggers its trimerization, which leads to the assembly of the receptor complex and initiation of signaling. | SIGNOR-199091 |
O14757 | Q13535 | 0 | phosphorylation | up-regulates | 0.925 | Atr activation typically leads to chk1 phosphorylation and activation. In response to genotoxic stress, chk1 is phosphorylated on serines 317 (s317) and 345 (s345) by the ataxia-telangiectasia-related (atr) protein kinase. | SIGNOR-134716 |
Q9Y478 | Q13131 | 0 | phosphorylation | up-regulates | 0.925 | Mutation of serine 108 to alanine, an autophosphorylation site within the glycogen binding domain of the beta1 subunit, almost completely abolishes activation of ampk by a-769662 in cells and in vitro, while only partially reducing activation by amp | SIGNOR-157553 |
Q01638 | O95760 | 0 | binding | up-regulates activity | 0.925 | We report a member of the IL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.The binding of IL-33 to cells that express ST2 results in the activation of NF-κB and MAP kinases. Administration of purified IL-33 either in vitro or in vivo leads to the production of TH2-associated cytokines. | SIGNOR-277711 |
Q9HC73 | Q969D9 | 0 | binding | up-regulates | 0.924 | Human tslp is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human tslp receptor and the il-7r alpha-chain. | SIGNOR-108920 |
Q96F46 | Q16552 | 0 | binding | up-regulates | 0.924 | Binding studies suggest that recombinant hil-17 binds to the hil-17r with low affinity. Monoclonal antibodies (mabs) generated against the hil-17r were able to block the il-17-induced production of cytokine from human foreskin fibroblast (hff) cells. | SIGNOR-53249 |
Q02763 | O15123 | 0 | binding | up-regulates | 0.924 | Angiopoietin-1 and -2, bound to tek with similar affinities, and angiopoietin-1 effectively induced tek phosphorylation in hematopoietic cells. Angiopoietin-2 also induced a low level of tek phosphorylation and weakened the phosphorylation induced by angiopoietin-1 | SIGNOR-59808 |
P54764 | O43921 | 0 | binding | up-regulates | 0.924 | Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). In either case, binding of a ligand results in eph receptor autophosphorylation on tyrosine residues and activation of the kinase activity of the eph receptor | SIGNOR-52203 |
P51531 | Q12824 | 0 | binding | up-regulates activity | 0.924 | The remodeling activity of brg1 and hbrm is stimulated by baf170/baf155 and is further stimulated when ini1 is added. | SIGNOR-65181 |
P42336 | P01112 | 0 | binding | up-regulates | 0.924 | In vivo, dominant negative ras mutant n17 inhibits growth factor induced production of 3' phosphorylated phosphoinositides in pc12 cells, and transfection of ras, but not raf, into cos cells results in a large elevation in the level of these lipids. Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. it was also described that ras interacts with pi3k in a direct manner. lysine residue 227 is essential for the interaction of ras with pi3k | SIGNOR-35878 |
P16471 | P01236 | 0 | binding | up-regulates | 0.924 | Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor (prlr). | SIGNOR-72810 |
P08100 | Q15835 | 0 | phosphorylation | up-regulates activity | 0.923 | That light-dependent phosphorylation of Rho is mediated primarily by RK. Addition of an inhibitory antibody against rhodopsin kinase (RK) lowered phosphorylation at Ser334, Ser338, and Ser343, without changing the ratio between phosphorylation sites. upon illumination, Ser334c, Ser338, and Ser343 are phosphorylated. | SIGNOR-251190 |
P62993 | P00533 | 0 | binding | up-regulates activity | 0.923 | Adaptor protein Grb2 binds phosphotyrosines in the epidermal growth factor (EGF) receptor (EGFR) and thereby links receptor activation to intracellular signaling cascades. | SIGNOR-267725 |
P46531 | Q92585 | 0 | binding | up-regulates | 0.923 | Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes1.Maml1 functions as a transcriptional co-activator for notch signalling. | SIGNOR-86117 |
P49810 | Q96BI3 | 0 | binding | up-regulates | 0.923 | Gamma secretase subunit. Leads to ps1/ps2 eterodimer complex stabilisation. By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain. | SIGNOR-93265 |
P20339 | Q9UJ41 | 0 | binding | up-regulates | 0.923 | We have previously shown that rab5, which regulates various steps of transport along the early endocytic pathway, is activated by a complex consisting of rabex-5, a rab5 nucleotide exchange factor, and the effector rabaptin-5. | SIGNOR-109398 |
O60716 | P12931 | 0 | phosphorylation | up-regulates activity | 0.922 | Identification of Src phosphorylation sites in the catenin p120ctn.Using selected tyrosine to phenylalanine p120 mutants as dominant negative reagents, it may now be possible to selectively block events postulated to be dependent on p120 tyrosine phosphorylation.combinations of Tyr _ Phe mutations at residues 96, 112, 228, 257, 280, 291, 296, and 302 | SIGNOR-246484 |
P55211 | P98170 | 0 | binding | down-regulates quantity by destabilization | 0.922 | A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis | SIGNOR-105702 |
P14635 | P53350 | 0 | phosphorylation | up-regulates activity | 0.922 | Phosphorylation of cyclin b1 is central to its nuclear translocationduring cell-cycle progression in hela cells, a change in the kinase activity of endogenous plk1 toward s147 and/or s133 correlates with a kinase activity in the cell extractsa mutant cyclin b1 in which s133 and s147 are replaced by alanines remains in the cytoplasm, whereas wild-type cyclin b1 accumulates in the nucleus during prophase.Together, these results suggest that phosphorylation of s133 and s147 is necessary for the nuclear translocation of cyclin b1 during prophase, and that phosphorylation of s126 and s128 may stimulate the nuclear translocation. | SIGNOR-105719 |
P29317 | P52803 | 0 | binding | up-regulates | 0.922 | Members of the epha subfamily of receptor tyrosine kinases and their ephrin-a ligands have been implicated in the guidance of retinal axons along the anterior-posterior axis of the chick optic tectum. | SIGNOR-52467 |
P25963 | O14920 | 0 | phosphorylation | down-regulates activity | 0.922 | Tak1 become activated and then phosphorilates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation | SIGNOR-235400 |
Q16623 | P61764 | 0 | binding | up-regulates activity | 0.922 | Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. | SIGNOR-264042 |
Q15382 | P49815 | 0 | gtpase-activating protein | down-regulates activity | 0.922 | Tsc2 functions as a gap to inhibit rheb activity. Tsc2 displays gap (gtpase-activating protein) activity specifically towards the small g protein rheb and inhibits its ability to stimulate the mtor signaling pathway. It has recently been shown that tsc2 has gtpase-activating protein (gap) activity towards the ras family small gtpase rheb (ras homolog enriched in brain), and tsc1/2 antagonizes the mtor signaling pathway via stimulation of gtp hydrolysis of rheb. | SIGNOR-128432 |
Q9Y4K3 | Q99836 | 0 | binding | up-regulates activity | 0.922 | In innate immunity, nearly all Toll-like receptors (TLRs), as well as the receptors of the interleukin 1 (IL-1) family of cytokines, initiate signaling by recruiting the adaptor protein MyD88. This is followed by the interaction of IL-1-receptor (IL-R)-associated kinase 4 (IRAK4) with MyD88 and then the interaction of other IRAK family members with IRAK4, to form an oligomeric complex, termed the Myddosome (8, 9). IRAK1 and IRAK2 can then interact with TRAF6 (10, 11) and induce TRAF6 dimerization (12), which triggers the activation of its E3 ligase activity | SIGNOR-260160 |
P05362 | P20701 | 0 | binding | up-regulates | 0.922 | This leads to further neutrophil-endothelial cell interactions through the binding of LFA-1 to its endothelial counterreceptor ICAM-1 during the slow rolling phase | SIGNOR-255040 |
Q01094 | P06400 | 0 | binding | down-regulates activity | 0.921 | E2f binds rb. E2f activation domain is the target for rb-induced repression. Rb can silence the 57 residue e2f activation domain. Rb can mask e2f residues involved in the activation process, possibly by mimicking a component of the transcriptional machinery | SIGNOR-37305 |
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